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Q8NEN9

- PDZD8_HUMAN

UniProt

Q8NEN9 - PDZD8_HUMAN

Protein

PDZ domain-containing protein 8

Gene

PDZD8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Plays a role in the regulation of cell morphology and cytoskeletal organization. May inhibit herpes simplex virus 1 infection at an early stage. May promote retroviral infection.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri840 – 89152Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cytoskeleton organization Source: UniProtKB
    2. intracellular signal transduction Source: InterPro
    3. regulation of cell morphogenesis Source: UniProtKB
    4. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PDZ domain-containing protein 8
    Alternative name(s):
    Sarcoma antigen NY-SAR-84/NY-SAR-104
    Gene namesi
    Name:PDZD8
    Synonyms:PDZK8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:26974. PDZD8.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134916380.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11541154PDZ domain-containing protein 8PRO_0000058299Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei496 – 4961Phosphoserine2 Publications
    Modified residuei538 – 5381Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8NEN9.
    PaxDbiQ8NEN9.
    PRIDEiQ8NEN9.

    PTM databases

    PhosphoSiteiQ8NEN9.

    Expressioni

    Gene expression databases

    BgeeiQ8NEN9.
    CleanExiHS_PDZD8.
    GenevestigatoriQ8NEN9.

    Organism-specific databases

    HPAiHPA015716.
    HPA051610.

    Interactioni

    Subunit structurei

    Interacts with MSN. Interacts with HIV-1 Gag polyprotein p55.2 Publications

    Protein-protein interaction databases

    BioGridi125631. 3 interactions.
    STRINGi9606.ENSP00000334642.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NEN9.
    SMRiQ8NEN9. Positions 364-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini366 – 44984PDZPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1028 – 106336Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi551 – 62676Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri840 – 89152Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG292931.
    HOGENOMiHOG000090230.
    HOVERGENiHBG082118.
    InParanoidiQ8NEN9.
    OMAiVFIAVKE.
    OrthoDBiEOG786H2V.
    PhylomeDBiQ8NEN9.
    TreeFamiTF324166.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    InterProiIPR001478. PDZ.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    [Graphical view]
    PfamiPF00130. C1_1. 1 hit.
    PF13180. PDZ_2. 1 hit.
    [Graphical view]
    SMARTiSM00109. C1. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NEN9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLLLMILAS AVLGSFLTLL AQFFLLYRRQ PEPPADEAAR AGEGFRYIKP     50
    VPGLLLREYL YGGGRDEEPS GAAPEGGATP TAAPETPAPP TRETCYFLNA 100
    TILFLFRELR DTALTRRWVT KKIKVEFEEL LQTKTAGRLL EGLSLRDVFL 150
    GETVPFIKTI RLVRPVVPSA TGEPDGPEGE ALPAACPEEL AFEAEVEYNG 200
    GFHLAIDVDL VFGKSAYLFV KLSRVVGRLR LVFTRVPFTH WFFSFVEDPL 250
    IDFEVRSQFE GRPMPQLTSI IVNQLKKIIK RKHTLPNYKI RFKPFFPYQT 300
    LQGFEEDEEH IHIQQWALTE GRLKVTLLEC SRLLIFGSYD REANVHCTLE 350
    LSSSVWEEKQ RSSIKTVELI KGNLQSVGLT LRLVQSTDGY AGHVIIETVA 400
    PNSPAAIADL QRGDRLIAIG GVKITSTLQV LKLIKQAGDR VLVYYERPVG 450
    QSNQGAVLQD NFGQLEENFL SSSCQSGYEE EAAGLTVDTE SRELDSEFED 500
    LASDVRAQNE FKDEAQSLSH SPKRVPTTLS IKPLGAISPV LNRKLAVGSH 550
    PLPPKIQSKD GNKPPPLKTS EITDPAQVSK PTQGSAFKPP VPPRPQAKVP 600
    LPSADAPNQA EPDVLVEKPE KVVPPPLVDK SAEKQAKNVD AIDDAAAPKQ 650
    FLAKQEVAKD VTSETSCPTK DSSDDRQTWE SSEILYRNKL GKWTRTRASC 700
    LFDIEACHRY LNIALWCRDP FKLGGLICLG HVSLKLEDVA LGCLATSNTE 750
    YLSKLRLEAP SPKAIVTRTA LRNLSMQKGF NDKFCYGDIT IHFKYLKEGE 800
    SDHHVVTNVE KEKEPHLVEE VSVLPKEEQF VGQMGLTENK HSFQDTQFQN 850
    PTWCDYCKKK VWTKAASQCM FCAYVCHKKC QEKCLAETSV CGATDRRIDR 900
    TLKNLRLEGQ ETLLGLPPRV DAEASKSVNK TTGLTRHIIN TSSRLLNLRQ 950
    VSKTRLSEPG TDLVEPSPKH TPNTSDNEGS DTEVCGPNSP SKRGNSTGIK 1000
    LVRKEGGLDD SVFIAVKEIG RDLYRGLPTE ERIQKLEFML DKLQNEIDQE 1050
    LEHNNSLVRE EKETTDTRKK SLLSAALAKS GERLQALTLL MIHYRAGIED 1100
    IETLESLSLD QHSKKISKYT DDTEEDLDNE ISQLIDSQPF SSISDDLFGP 1150
    SESV 1154
    Length:1,154
    Mass (Da):128,563
    Last modified:October 1, 2002 - v1
    Checksum:iB09263C483645B13
    GO

    Sequence cautioni

    The sequence AAO65182.1 differs from that shown. Reason: Frameshift at position 421.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti232 – 2321V → G in AAO65182. (PubMed:12601173)Curated
    Sequence conflicti482 – 4821A → T in AAO65182. (PubMed:12601173)Curated
    Sequence conflicti488 – 4881D → N in AAO65182. (PubMed:12601173)Curated
    Sequence conflicti491 – 4911S → K in AAO65182. (PubMed:12601173)Curated
    Sequence conflicti666 – 6661S → F in CAB59184. (PubMed:17974005)Curated
    Sequence conflicti1007 – 10082GL → RG in AAO65177. (PubMed:12601173)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti806 – 8061V → A.
    Corresponds to variant rs35664484 [ dbSNP | Ensembl ].
    VAR_051265
    Natural varianti897 – 8971R → Q.
    Corresponds to variant rs363294 [ dbSNP | Ensembl ].
    VAR_051266

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL391988, AL359836 Genomic DNA. Translation: CAH70347.1.
    AL359836, AL391988 Genomic DNA. Translation: CAH73253.1.
    BC028375 mRNA. Translation: AAH28375.1.
    AY211924 mRNA. Translation: AAO65177.1.
    AY211929 mRNA. Translation: AAO65182.1. Frameshift.
    AL122051 mRNA. Translation: CAB59184.1.
    CCDSiCCDS7600.1.
    PIRiT34546.
    RefSeqiNP_776152.1. NM_173791.3.
    UniGeneiHs.501149.

    Genome annotation databases

    EnsembliENST00000334464; ENSP00000334642; ENSG00000165650.
    GeneIDi118987.
    KEGGihsa:118987.
    UCSCiuc001lde.1. human.

    Polymorphism databases

    DMDMi73621383.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL391988 , AL359836 Genomic DNA. Translation: CAH70347.1 .
    AL359836 , AL391988 Genomic DNA. Translation: CAH73253.1 .
    BC028375 mRNA. Translation: AAH28375.1 .
    AY211924 mRNA. Translation: AAO65177.1 .
    AY211929 mRNA. Translation: AAO65182.1 . Frameshift.
    AL122051 mRNA. Translation: CAB59184.1 .
    CCDSi CCDS7600.1.
    PIRi T34546.
    RefSeqi NP_776152.1. NM_173791.3.
    UniGenei Hs.501149.

    3D structure databases

    ProteinModelPortali Q8NEN9.
    SMRi Q8NEN9. Positions 364-449.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125631. 3 interactions.
    STRINGi 9606.ENSP00000334642.

    PTM databases

    PhosphoSitei Q8NEN9.

    Polymorphism databases

    DMDMi 73621383.

    Proteomic databases

    MaxQBi Q8NEN9.
    PaxDbi Q8NEN9.
    PRIDEi Q8NEN9.

    Protocols and materials databases

    DNASUi 118987.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334464 ; ENSP00000334642 ; ENSG00000165650 .
    GeneIDi 118987.
    KEGGi hsa:118987.
    UCSCi uc001lde.1. human.

    Organism-specific databases

    CTDi 118987.
    GeneCardsi GC10M119033.
    HGNCi HGNC:26974. PDZD8.
    HPAi HPA015716.
    HPA051610.
    MIMi 614235. gene.
    neXtProti NX_Q8NEN9.
    PharmGKBi PA134916380.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG292931.
    HOGENOMi HOG000090230.
    HOVERGENi HBG082118.
    InParanoidi Q8NEN9.
    OMAi VFIAVKE.
    OrthoDBi EOG786H2V.
    PhylomeDBi Q8NEN9.
    TreeFami TF324166.

    Miscellaneous databases

    ChiTaRSi PDZD8. human.
    GenomeRNAii 118987.
    NextBioi 80380.
    PROi Q8NEN9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8NEN9.
    CleanExi HS_PDZD8.
    Genevestigatori Q8NEN9.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    InterProi IPR001478. PDZ.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    [Graphical view ]
    Pfami PF00130. C1_1. 1 hit.
    PF13180. PDZ_2. 1 hit.
    [Graphical view ]
    SMARTi SM00109. C1. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 232-491 AND 1007-1154.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 642-1154.
      Tissue: Testis.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496 AND SER-538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    7. "PDZD8 is a novel Gag-interacting factor that promotes retroviral infection."
      Henning M.S., Morham S.G., Goff S.P., Naghavi M.H.
      J. Virol. 84:8990-8995(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH HIV-1 GAG.
    8. "Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."
      Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J.
      BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "PDZD8 is a novel moesin-interacting cytoskeletal regulatory protein that suppresses infection by herpes simplex virus type 1."
      Henning M.S., Stiedl P., Barry D.S., McMahon R., Morham S.G., Walsh D., Naghavi M.H.
      Virology 415:114-121(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MSN.

    Entry informationi

    Entry nameiPDZD8_HUMAN
    AccessioniPrimary (citable) accession number: Q8NEN9
    Secondary accession number(s): Q86WE0, Q86WE5, Q9UFF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3