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Q8NEN9

- PDZD8_HUMAN

UniProt

Q8NEN9 - PDZD8_HUMAN

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Protein

PDZ domain-containing protein 8

Gene

PDZD8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization. May inhibit herpes simplex virus 1 infection at an early stage. May promote retroviral infection.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri840 – 89152Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cytoskeleton organization Source: UniProtKB
  2. intracellular signal transduction Source: InterPro
  3. regulation of cell morphogenesis Source: UniProtKB
  4. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ domain-containing protein 8
Alternative name(s):
Sarcoma antigen NY-SAR-84/NY-SAR-104
Gene namesi
Name:PDZD8
Synonyms:PDZK8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:26974. PDZD8.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134916380.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11541154PDZ domain-containing protein 8PRO_0000058299Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei496 – 4961Phosphoserine2 Publications
Modified residuei538 – 5381Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8NEN9.
PaxDbiQ8NEN9.
PRIDEiQ8NEN9.

PTM databases

PhosphoSiteiQ8NEN9.

Expressioni

Gene expression databases

BgeeiQ8NEN9.
CleanExiHS_PDZD8.
GenevestigatoriQ8NEN9.

Organism-specific databases

HPAiHPA015716.
HPA051610.

Interactioni

Subunit structurei

Interacts with MSN. Interacts with HIV-1 Gag polyprotein p55.2 Publications

Protein-protein interaction databases

BioGridi125631. 10 interactions.
STRINGi9606.ENSP00000334642.

Structurei

3D structure databases

ProteinModelPortaliQ8NEN9.
SMRiQ8NEN9. Positions 364-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini366 – 44984PDZPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1028 – 106336Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi551 – 62676Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri840 – 89152Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG292931.
GeneTreeiENSGT00390000017746.
HOGENOMiHOG000090230.
HOVERGENiHBG082118.
InParanoidiQ8NEN9.
OMAiVFIAVKE.
OrthoDBiEOG786H2V.
PhylomeDBiQ8NEN9.
TreeFamiTF324166.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR002219. PE/DAG-bd.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF13180. PDZ_2. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NEN9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLLLMILAS AVLGSFLTLL AQFFLLYRRQ PEPPADEAAR AGEGFRYIKP
60 70 80 90 100
VPGLLLREYL YGGGRDEEPS GAAPEGGATP TAAPETPAPP TRETCYFLNA
110 120 130 140 150
TILFLFRELR DTALTRRWVT KKIKVEFEEL LQTKTAGRLL EGLSLRDVFL
160 170 180 190 200
GETVPFIKTI RLVRPVVPSA TGEPDGPEGE ALPAACPEEL AFEAEVEYNG
210 220 230 240 250
GFHLAIDVDL VFGKSAYLFV KLSRVVGRLR LVFTRVPFTH WFFSFVEDPL
260 270 280 290 300
IDFEVRSQFE GRPMPQLTSI IVNQLKKIIK RKHTLPNYKI RFKPFFPYQT
310 320 330 340 350
LQGFEEDEEH IHIQQWALTE GRLKVTLLEC SRLLIFGSYD REANVHCTLE
360 370 380 390 400
LSSSVWEEKQ RSSIKTVELI KGNLQSVGLT LRLVQSTDGY AGHVIIETVA
410 420 430 440 450
PNSPAAIADL QRGDRLIAIG GVKITSTLQV LKLIKQAGDR VLVYYERPVG
460 470 480 490 500
QSNQGAVLQD NFGQLEENFL SSSCQSGYEE EAAGLTVDTE SRELDSEFED
510 520 530 540 550
LASDVRAQNE FKDEAQSLSH SPKRVPTTLS IKPLGAISPV LNRKLAVGSH
560 570 580 590 600
PLPPKIQSKD GNKPPPLKTS EITDPAQVSK PTQGSAFKPP VPPRPQAKVP
610 620 630 640 650
LPSADAPNQA EPDVLVEKPE KVVPPPLVDK SAEKQAKNVD AIDDAAAPKQ
660 670 680 690 700
FLAKQEVAKD VTSETSCPTK DSSDDRQTWE SSEILYRNKL GKWTRTRASC
710 720 730 740 750
LFDIEACHRY LNIALWCRDP FKLGGLICLG HVSLKLEDVA LGCLATSNTE
760 770 780 790 800
YLSKLRLEAP SPKAIVTRTA LRNLSMQKGF NDKFCYGDIT IHFKYLKEGE
810 820 830 840 850
SDHHVVTNVE KEKEPHLVEE VSVLPKEEQF VGQMGLTENK HSFQDTQFQN
860 870 880 890 900
PTWCDYCKKK VWTKAASQCM FCAYVCHKKC QEKCLAETSV CGATDRRIDR
910 920 930 940 950
TLKNLRLEGQ ETLLGLPPRV DAEASKSVNK TTGLTRHIIN TSSRLLNLRQ
960 970 980 990 1000
VSKTRLSEPG TDLVEPSPKH TPNTSDNEGS DTEVCGPNSP SKRGNSTGIK
1010 1020 1030 1040 1050
LVRKEGGLDD SVFIAVKEIG RDLYRGLPTE ERIQKLEFML DKLQNEIDQE
1060 1070 1080 1090 1100
LEHNNSLVRE EKETTDTRKK SLLSAALAKS GERLQALTLL MIHYRAGIED
1110 1120 1130 1140 1150
IETLESLSLD QHSKKISKYT DDTEEDLDNE ISQLIDSQPF SSISDDLFGP

SESV
Length:1,154
Mass (Da):128,563
Last modified:October 1, 2002 - v1
Checksum:iB09263C483645B13
GO

Sequence cautioni

The sequence AAO65182.1 differs from that shown. Reason: Frameshift at position 421. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti232 – 2321V → G in AAO65182. (PubMed:12601173)Curated
Sequence conflicti482 – 4821A → T in AAO65182. (PubMed:12601173)Curated
Sequence conflicti488 – 4881D → N in AAO65182. (PubMed:12601173)Curated
Sequence conflicti491 – 4911S → K in AAO65182. (PubMed:12601173)Curated
Sequence conflicti666 – 6661S → F in CAB59184. (PubMed:17974005)Curated
Sequence conflicti1007 – 10082GL → RG in AAO65177. (PubMed:12601173)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti806 – 8061V → A.
Corresponds to variant rs35664484 [ dbSNP | Ensembl ].
VAR_051265
Natural varianti897 – 8971R → Q.
Corresponds to variant rs363294 [ dbSNP | Ensembl ].
VAR_051266

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391988, AL359836 Genomic DNA. Translation: CAH70347.1.
AL359836, AL391988 Genomic DNA. Translation: CAH73253.1.
BC028375 mRNA. Translation: AAH28375.1.
AY211924 mRNA. Translation: AAO65177.1.
AY211929 mRNA. Translation: AAO65182.1. Frameshift.
AL122051 mRNA. Translation: CAB59184.1.
CCDSiCCDS7600.1.
PIRiT34546.
RefSeqiNP_776152.1. NM_173791.3.
UniGeneiHs.501149.

Genome annotation databases

EnsembliENST00000334464; ENSP00000334642; ENSG00000165650.
GeneIDi118987.
KEGGihsa:118987.
UCSCiuc001lde.1. human.

Polymorphism databases

DMDMi73621383.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391988 , AL359836 Genomic DNA. Translation: CAH70347.1 .
AL359836 , AL391988 Genomic DNA. Translation: CAH73253.1 .
BC028375 mRNA. Translation: AAH28375.1 .
AY211924 mRNA. Translation: AAO65177.1 .
AY211929 mRNA. Translation: AAO65182.1 . Frameshift.
AL122051 mRNA. Translation: CAB59184.1 .
CCDSi CCDS7600.1.
PIRi T34546.
RefSeqi NP_776152.1. NM_173791.3.
UniGenei Hs.501149.

3D structure databases

ProteinModelPortali Q8NEN9.
SMRi Q8NEN9. Positions 364-449.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125631. 10 interactions.
STRINGi 9606.ENSP00000334642.

PTM databases

PhosphoSitei Q8NEN9.

Polymorphism databases

DMDMi 73621383.

Proteomic databases

MaxQBi Q8NEN9.
PaxDbi Q8NEN9.
PRIDEi Q8NEN9.

Protocols and materials databases

DNASUi 118987.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334464 ; ENSP00000334642 ; ENSG00000165650 .
GeneIDi 118987.
KEGGi hsa:118987.
UCSCi uc001lde.1. human.

Organism-specific databases

CTDi 118987.
GeneCardsi GC10M119033.
HGNCi HGNC:26974. PDZD8.
HPAi HPA015716.
HPA051610.
MIMi 614235. gene.
neXtProti NX_Q8NEN9.
PharmGKBi PA134916380.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG292931.
GeneTreei ENSGT00390000017746.
HOGENOMi HOG000090230.
HOVERGENi HBG082118.
InParanoidi Q8NEN9.
OMAi VFIAVKE.
OrthoDBi EOG786H2V.
PhylomeDBi Q8NEN9.
TreeFami TF324166.

Miscellaneous databases

ChiTaRSi PDZD8. human.
GenomeRNAii 118987.
NextBioi 80380.
PROi Q8NEN9.
SOURCEi Search...

Gene expression databases

Bgeei Q8NEN9.
CleanExi HS_PDZD8.
Genevestigatori Q8NEN9.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
InterProi IPR001478. PDZ.
IPR002219. PE/DAG-bd.
[Graphical view ]
Pfami PF00130. C1_1. 1 hit.
PF13180. PDZ_2. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
PROSITEi PS50106. PDZ. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 232-491 AND 1007-1154.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 642-1154.
    Tissue: Testis.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496 AND SER-538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "PDZD8 is a novel Gag-interacting factor that promotes retroviral infection."
    Henning M.S., Morham S.G., Goff S.P., Naghavi M.H.
    J. Virol. 84:8990-8995(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH HIV-1 GAG.
  8. "Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."
    Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J.
    BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "PDZD8 is a novel moesin-interacting cytoskeletal regulatory protein that suppresses infection by herpes simplex virus type 1."
    Henning M.S., Stiedl P., Barry D.S., McMahon R., Morham S.G., Walsh D., Naghavi M.H.
    Virology 415:114-121(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MSN.

Entry informationi

Entry nameiPDZD8_HUMAN
AccessioniPrimary (citable) accession number: Q8NEN9
Secondary accession number(s): Q86WE0, Q86WE5, Q9UFF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3