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Q8NEN9 (PDZD8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
PDZ domain-containing protein 8
Alternative name(s):
Sarcoma antigen NY-SAR-84/NY-SAR-104
Gene names
Name:PDZD8
Synonyms:PDZK8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1154 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the regulation of cell morphology and cytoskeletal organization. May inhibit herpes simplex virus 1 infection at an early stage. May promote retroviral infection. Ref.7 Ref.8 Ref.9

Subunit structure

Interacts with MSN. Interacts with HIV-1 Gag polyprotein p55. Ref.7 Ref.9

Sequence similarities

Contains 1 PDZ (DHR) domain.

Contains 1 phorbol-ester/DAG-type zinc finger.

Sequence caution

The sequence AAO65182.1 differs from that shown. Reason: Frameshift at position 421.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11541154PDZ domain-containing protein 8
PRO_0000058299

Regions

Domain366 – 44984PDZ
Zinc finger840 – 89152Phorbol-ester/DAG-type
Coiled coil1028 – 106336 Potential
Compositional bias551 – 62676Pro-rich

Amino acid modifications

Modified residue4961Phosphoserine Ref.5 Ref.6
Modified residue5381Phosphoserine Ref.5

Natural variations

Natural variant8061V → A.
Corresponds to variant rs35664484 [ dbSNP | Ensembl ].
VAR_051265
Natural variant8971R → Q.
Corresponds to variant rs363294 [ dbSNP | Ensembl ].
VAR_051266

Experimental info

Sequence conflict2321V → G in AAO65182. Ref.3
Sequence conflict4821A → T in AAO65182. Ref.3
Sequence conflict4881D → N in AAO65182. Ref.3
Sequence conflict4911S → K in AAO65182. Ref.3
Sequence conflict6661S → F in CAB59184. Ref.4
Sequence conflict1007 – 10082GL → RG in AAO65177. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8NEN9 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: B09263C483645B13

FASTA1,154128,563
        10         20         30         40         50         60 
MGLLLMILAS AVLGSFLTLL AQFFLLYRRQ PEPPADEAAR AGEGFRYIKP VPGLLLREYL 

        70         80         90        100        110        120 
YGGGRDEEPS GAAPEGGATP TAAPETPAPP TRETCYFLNA TILFLFRELR DTALTRRWVT 

       130        140        150        160        170        180 
KKIKVEFEEL LQTKTAGRLL EGLSLRDVFL GETVPFIKTI RLVRPVVPSA TGEPDGPEGE 

       190        200        210        220        230        240 
ALPAACPEEL AFEAEVEYNG GFHLAIDVDL VFGKSAYLFV KLSRVVGRLR LVFTRVPFTH 

       250        260        270        280        290        300 
WFFSFVEDPL IDFEVRSQFE GRPMPQLTSI IVNQLKKIIK RKHTLPNYKI RFKPFFPYQT 

       310        320        330        340        350        360 
LQGFEEDEEH IHIQQWALTE GRLKVTLLEC SRLLIFGSYD REANVHCTLE LSSSVWEEKQ 

       370        380        390        400        410        420 
RSSIKTVELI KGNLQSVGLT LRLVQSTDGY AGHVIIETVA PNSPAAIADL QRGDRLIAIG 

       430        440        450        460        470        480 
GVKITSTLQV LKLIKQAGDR VLVYYERPVG QSNQGAVLQD NFGQLEENFL SSSCQSGYEE 

       490        500        510        520        530        540 
EAAGLTVDTE SRELDSEFED LASDVRAQNE FKDEAQSLSH SPKRVPTTLS IKPLGAISPV 

       550        560        570        580        590        600 
LNRKLAVGSH PLPPKIQSKD GNKPPPLKTS EITDPAQVSK PTQGSAFKPP VPPRPQAKVP 

       610        620        630        640        650        660 
LPSADAPNQA EPDVLVEKPE KVVPPPLVDK SAEKQAKNVD AIDDAAAPKQ FLAKQEVAKD 

       670        680        690        700        710        720 
VTSETSCPTK DSSDDRQTWE SSEILYRNKL GKWTRTRASC LFDIEACHRY LNIALWCRDP 

       730        740        750        760        770        780 
FKLGGLICLG HVSLKLEDVA LGCLATSNTE YLSKLRLEAP SPKAIVTRTA LRNLSMQKGF 

       790        800        810        820        830        840 
NDKFCYGDIT IHFKYLKEGE SDHHVVTNVE KEKEPHLVEE VSVLPKEEQF VGQMGLTENK 

       850        860        870        880        890        900 
HSFQDTQFQN PTWCDYCKKK VWTKAASQCM FCAYVCHKKC QEKCLAETSV CGATDRRIDR 

       910        920        930        940        950        960 
TLKNLRLEGQ ETLLGLPPRV DAEASKSVNK TTGLTRHIIN TSSRLLNLRQ VSKTRLSEPG 

       970        980        990       1000       1010       1020 
TDLVEPSPKH TPNTSDNEGS DTEVCGPNSP SKRGNSTGIK LVRKEGGLDD SVFIAVKEIG 

      1030       1040       1050       1060       1070       1080 
RDLYRGLPTE ERIQKLEFML DKLQNEIDQE LEHNNSLVRE EKETTDTRKK SLLSAALAKS 

      1090       1100       1110       1120       1130       1140 
GERLQALTLL MIHYRAGIED IETLESLSLD QHSKKISKYT DDTEEDLDNE ISQLIDSQPF 

      1150 
SSISDDLFGP SESV 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"Immunomic analysis of human sarcoma."
Lee S.-Y., Obata Y., Yoshida M., Stockert E., Williamson B., Jungbluth A.A., Chen Y.-T., Old L.J., Scanlan M.J.
Proc. Natl. Acad. Sci. U.S.A. 100:2651-2656(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 232-491 AND 1007-1154.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 642-1154.
Tissue: Testis.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496 AND SER-538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[7]"PDZD8 is a novel Gag-interacting factor that promotes retroviral infection."
Henning M.S., Morham S.G., Goff S.P., Naghavi M.H.
J. Virol. 84:8990-8995(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH HIV-1 GAG.
[8]"Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."
Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J.
BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"PDZD8 is a novel moesin-interacting cytoskeletal regulatory protein that suppresses infection by herpes simplex virus type 1."
Henning M.S., Stiedl P., Barry D.S., McMahon R., Morham S.G., Walsh D., Naghavi M.H.
Virology 415:114-121(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH MSN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL391988, AL359836 Genomic DNA. Translation: CAH70347.1.
AL359836, AL391988 Genomic DNA. Translation: CAH73253.1.
BC028375 mRNA. Translation: AAH28375.1.
AY211924 mRNA. Translation: AAO65177.1.
AY211929 mRNA. Translation: AAO65182.1. Frameshift.
AL122051 mRNA. Translation: CAB59184.1.
CCDSCCDS7600.1.
PIRT34546.
RefSeqNP_776152.1. NM_173791.3.
UniGeneHs.501149.

3D structure databases

ProteinModelPortalQ8NEN9.
SMRQ8NEN9. Positions 364-449.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125631. 3 interactions.
STRING9606.ENSP00000334642.

PTM databases

PhosphoSiteQ8NEN9.

Polymorphism databases

DMDM73621383.

Proteomic databases

MaxQBQ8NEN9.
PaxDbQ8NEN9.
PRIDEQ8NEN9.

Protocols and materials databases

DNASU118987.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334464; ENSP00000334642; ENSG00000165650.
GeneID118987.
KEGGhsa:118987.
UCSCuc001lde.1. human.

Organism-specific databases

CTD118987.
GeneCardsGC10M119033.
HGNCHGNC:26974. PDZD8.
HPAHPA015716.
HPA051610.
MIM614235. gene.
neXtProtNX_Q8NEN9.
PharmGKBPA134916380.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG292931.
HOGENOMHOG000090230.
HOVERGENHBG082118.
InParanoidQ8NEN9.
OMAVFIAVKE.
OrthoDBEOG786H2V.
PhylomeDBQ8NEN9.
TreeFamTF324166.

Gene expression databases

BgeeQ8NEN9.
CleanExHS_PDZD8.
GenevestigatorQ8NEN9.

Family and domain databases

Gene3D2.30.42.10. 1 hit.
InterProIPR001478. PDZ.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
[Graphical view]
PfamPF00130. C1_1. 1 hit.
PF13180. PDZ_2. 1 hit.
[Graphical view]
SMARTSM00109. C1. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF50156. SSF50156. 1 hit.
PROSITEPS50106. PDZ. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPDZD8. human.
GenomeRNAi118987.
NextBio80380.
PROQ8NEN9.
SOURCESearch...

Entry information

Entry namePDZD8_HUMAN
AccessionPrimary (citable) accession number: Q8NEN9
Secondary accession number(s): Q86WE0, Q86WE5, Q9UFF1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM