Reviewed, UniProtKB/Swiss-Prot Q8NEN0 (ARMC2_HUMAN)

Names and origin

Protein names

Recommended name:
    Armadillo repeat-containing protein 2

Gene names

Name:

ARMC2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	867 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities	Contains 12 ARM repeats.
Sequence caution	The sequence CAI16717.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 867	867	Armadillo repeat-containing protein 2		PRO_0000284401
Regions
	Repeat	262 – 301	40	ARM 1
	Repeat	304 – 344	41	ARM 2
	Repeat	363 – 403	41	ARM 3
	Repeat	408 – 449	42	ARM 4
	Repeat	462 – 503	42	ARM 5
	Repeat	506 – 547	42	ARM 6
	Repeat	551 – 589	39	ARM 7
	Repeat	591 – 616	26	ARM 8
	Repeat	619 – 662	44	ARM 9
	Repeat	664 – 705	42	ARM 10
	Repeat	707 – 746	40	ARM 11
	Repeat	748 – 790	43	ARM 12
Amino acid modifications
	Modified residue	218	1	Phosphoserine Ref.5
Natural variations
	Natural variant	166	1	M → T: dbSNP rs9386758.		VAR_031948
	Natural variant	433	1	N → D: dbSNP rs17852775. Ref.3		VAR_031949

Sequences

	Sequence		Length	Mass (Da)
	Q8NEN0-1 [UniParc]. Last modified March 18, 2008. Version 4. Checksum: 6DAC9F5DC26E5FB3	FASTA	867	96,867
	10 20 30 40 50 60 MLSPNDKMLG KLDPFYQPSV SKQKTSAEII SEARNALRTV RTQRPFTPQE AQRKLFGPAS 70 80 90 100 110 120 SRTSENRPPS SFSLHASSFE SSDSRPISGT RLSPLELKPK VPASPTREED SCFSFPKPPV 130 140 150 160 170 180 DPAKIRRVSN ARARLFRAAS QRALLPDRSL PPSDSKKTVE SKETVMMGDS MVKINGIYLT 190 200 210 220 230 240 KSNAICHLKS HPLQLTDDGG FSEIKEQEMF KGTTSLPSHL KNGGDQGKRH ARASSCPSSS 250 260 270 280 290 300 DLSRLQTKAV PKADLQEEDA EIEVDEVFWN TRIVPILREL EKEENIETVC AACTQLHHAL 310 320 330 340 350 360 EEGNMLGNKF KGRSILLKTL CKLVDVGSDS LSLKLAKIIL ALKVSRKNLL NVCKLIFKIS 370 380 390 400 410 420 RNEKNDSLIQ NDSILESLLE VLRSEDLQTN MEAFLYCMGS IKFISGNLGF LNEMISKGAV 430 440 450 460 470 480 EILINLIKQI NENIKKCGTF LPNSGHLLVQ VTATLRNLVD SSLVRSKFLN ISALPQLCTA 490 500 510 520 530 540 MEQYKGDKDV CTNIARIFSK LTSYRDCCTA LASYSRCYAL FLNLINKYQK KQDLVVRVVF 550 560 570 580 590 600 ILGNLTAKNN QAREQFSKEK GSIQTLLSLF QTFHQLDLHS QKPVGQRGEQ HRAQRPPSEA 610 620 630 640 650 660 EDVLIKLTRV LANIAIHPGV GPVLAANPGI VGLLLTTLEY KSLDDCEELV INATATINNL 670 680 690 700 710 720 SYYQVKNSII QDKKLYIAEL LLKLLVSNNM DGILEAVRVF GNLSQDHDVC DFIVQNNVHR 730 740 750 760 770 780 FMMALLDAQH QDICFSACGV LLNLTVDKDK RVILKEGGGI KKLVDCLRDL GPTDWQLACL 790 800 810 820 830 840 VCKTLWNFSE NITNASSCFG NEDTNTLLLL LSSFLDEELA LDGSFDPDLK NYHKLHWETE 850 860 FKPVAQQLLN RIQRHHTFLE PLPIPSF

References

[1]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-433. Tissue: Testis.
[4]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 160-867. Tissue: Testis.
[5]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-218, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL445189, AL390208 Genomic DNA. Translation: CAH71699.2. AK292499 mRNA. Translation: BAF85188.1. Different initiation. AL390208, AL445189 Genomic DNA. Translation: CAI16717.2. Sequence problems. BC030603 mRNA. Translation: AAH30603.2. Different initiation. AL136754 mRNA. Translation: CAB66688.2.
IPI	IPI00872354.
RefSeq	NP_115507.4.
UniGene	Hs.645481
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q8NEN0.
Genome annotation databases
Ensembl	ENST00000392644; ENSP00000376417; ENSG00000118690; Homo sapiens. [Genome view]
GeneID	84071.
KEGG	hsa:84071.
UCSC	uc003pss.2. human.
Organism-specific databases
CTD	84071.
GeneCards	GC06P109276.
HGNC	HGNC:23045. ARMC2.
HPA	HPA025809.
PharmGKB	PA134943829.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8NEN0.
OMA	FGNLSQD
OrthoDB	EOG9Q5C8T
Gene expression databases
ArrayExpress	Q8NEN0.
Bgee	Q8NEN0.
CleanEx	HS_ARMC2.
Genevestigator	Q8NEN0.
Family and domain databases
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 2 hits.
PROSITE	PS50176. ARM_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	73267.

Entry information

Entry name

ARMC2_HUMAN

Accession

Primary (citable) accession number: Q8NEN0
Secondary accession number(s): A8K8Y4, Q5VVY8, Q9H0K9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	March 18, 2008
Last modified:	November 24, 2009
This is version 60 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.