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Protein

Armadillo repeat-containing protein 2

Gene

ARMC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118690-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 2
Gene namesi
Name:ARMC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:23045. ARMC2.

Pathology & Biotechi

Organism-specific databases

DisGeNETi84071.
OpenTargetsiENSG00000118690.
PharmGKBiPA134943829.

Polymorphism and mutation databases

DMDMi172045816.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002844011 – 867Armadillo repeat-containing protein 2Add BLAST867

Proteomic databases

EPDiQ8NEN0.
PaxDbiQ8NEN0.
PeptideAtlasiQ8NEN0.
PRIDEiQ8NEN0.

PTM databases

iPTMnetiQ8NEN0.
PhosphoSitePlusiQ8NEN0.

Expressioni

Gene expression databases

BgeeiENSG00000118690.
CleanExiHS_ARMC2.
ExpressionAtlasiQ8NEN0. baseline and differential.
GenevisibleiQ8NEN0. HS.

Organism-specific databases

HPAiHPA025809.
HPA053696.

Interactioni

Protein-protein interaction databases

BioGridi123866. 1 interactor.
IntActiQ8NEN0. 2 interactors.
MINTiMINT-4714556.
STRINGi9606.ENSP00000376417.

Structurei

3D structure databases

ProteinModelPortaliQ8NEN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati262 – 301ARM 1Add BLAST40
Repeati304 – 344ARM 2Add BLAST41
Repeati363 – 403ARM 3Add BLAST41
Repeati408 – 449ARM 4Add BLAST42
Repeati462 – 503ARM 5Add BLAST42
Repeati506 – 547ARM 6Add BLAST42
Repeati551 – 589ARM 7Add BLAST39
Repeati591 – 616ARM 8Add BLAST26
Repeati619 – 662ARM 9Add BLAST44
Repeati664 – 705ARM 10Add BLAST42
Repeati707 – 746ARM 11Add BLAST40
Repeati748 – 790ARM 12Add BLAST43

Sequence similaritiesi

Contains 12 ARM repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IUKI. Eukaryota.
ENOG410XPBC. LUCA.
GeneTreeiENSGT00390000000663.
HOGENOMiHOG000034054.
HOVERGENiHBG059194.
InParanoidiQ8NEN0.
OMAiMEAFLYC.
OrthoDBiEOG091G0I4Q.
PhylomeDBiQ8NEN0.
TreeFamiTF329012.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
SMARTiSM00185. ARM. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NEN0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSPNDKMLG KLDPFYQPSV SKQKTSAEII SEARNALRTV RTQRPFTPQE
60 70 80 90 100
AQRKLFGPAS SRTSENRPPS SFSLHASSFE SSDSRPISGT RLSPLELKPK
110 120 130 140 150
VPASPTREED SCFSFPKPPV DPAKIRRVSN ARARLFRAAS QRALLPDRSL
160 170 180 190 200
PPSDSKKTVE SKETVMMGDS MVKINGIYLT KSNAICHLKS HPLQLTDDGG
210 220 230 240 250
FSEIKEQEMF KGTTSLPSHL KNGGDQGKRH ARASSCPSSS DLSRLQTKAV
260 270 280 290 300
PKADLQEEDA EIEVDEVFWN TRIVPILREL EKEENIETVC AACTQLHHAL
310 320 330 340 350
EEGNMLGNKF KGRSILLKTL CKLVDVGSDS LSLKLAKIIL ALKVSRKNLL
360 370 380 390 400
NVCKLIFKIS RNEKNDSLIQ NDSILESLLE VLRSEDLQTN MEAFLYCMGS
410 420 430 440 450
IKFISGNLGF LNEMISKGAV EILINLIKQI NENIKKCGTF LPNSGHLLVQ
460 470 480 490 500
VTATLRNLVD SSLVRSKFLN ISALPQLCTA MEQYKGDKDV CTNIARIFSK
510 520 530 540 550
LTSYRDCCTA LASYSRCYAL FLNLINKYQK KQDLVVRVVF ILGNLTAKNN
560 570 580 590 600
QAREQFSKEK GSIQTLLSLF QTFHQLDLHS QKPVGQRGEQ HRAQRPPSEA
610 620 630 640 650
EDVLIKLTRV LANIAIHPGV GPVLAANPGI VGLLLTTLEY KSLDDCEELV
660 670 680 690 700
INATATINNL SYYQVKNSII QDKKLYIAEL LLKLLVSNNM DGILEAVRVF
710 720 730 740 750
GNLSQDHDVC DFIVQNNVHR FMMALLDAQH QDICFSACGV LLNLTVDKDK
760 770 780 790 800
RVILKEGGGI KKLVDCLRDL GPTDWQLACL VCKTLWNFSE NITNASSCFG
810 820 830 840 850
NEDTNTLLLL LSSFLDEELA LDGSFDPDLK NYHKLHWETE FKPVAQQLLN
860
RIQRHHTFLE PLPIPSF
Length:867
Mass (Da):96,867
Last modified:March 18, 2008 - v4
Checksum:i6DAC9F5DC26E5FB3
GO
Isoform 2 (identifier: Q8NEN0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.

Note: No experimental confirmation available.
Show »
Length:702
Mass (Da):78,592
Checksum:i7A2BB78F29737A35
GO

Sequence cautioni

The sequence AAH30603 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAF85188 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI16717 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti392E → G in BAG57766 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031948166M → T.Corresponds to variant rs9386758dbSNPEnsembl.1
Natural variantiVAR_031949433N → D.1 PublicationCorresponds to variant rs17852775dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0556221 – 165Missing in isoform 2. 1 PublicationAdd BLAST165

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292499 mRNA. Translation: BAF85188.1. Different initiation.
AK294574 mRNA. Translation: BAG57766.1.
AL445189, AL390208 Genomic DNA. Translation: CAH71699.2.
AL390208, AL445189 Genomic DNA. Translation: CAI16717.2. Sequence problems.
CH471051 Genomic DNA. Translation: EAW48369.1.
BC030603 mRNA. Translation: AAH30603.2. Different initiation.
AL136754 mRNA. Translation: CAB66688.2.
CCDSiCCDS5069.2. [Q8NEN0-1]
CCDS69168.1. [Q8NEN0-2]
RefSeqiNP_001273538.1. NM_001286609.1. [Q8NEN0-2]
NP_115507.4. NM_032131.5. [Q8NEN0-1]
XP_005267211.1. XM_005267154.3. [Q8NEN0-1]
XP_005267212.1. XM_005267155.2. [Q8NEN0-1]
XP_005267214.1. XM_005267157.3. [Q8NEN0-2]
XP_006715636.1. XM_006715573.2. [Q8NEN0-1]
XP_006715637.1. XM_006715574.2. [Q8NEN0-2]
XP_011534468.1. XM_011536166.1. [Q8NEN0-1]
XP_011534474.1. XM_011536172.2. [Q8NEN0-2]
UniGeneiHs.645481.

Genome annotation databases

EnsembliENST00000368972; ENSP00000357968; ENSG00000118690. [Q8NEN0-2]
ENST00000392644; ENSP00000376417; ENSG00000118690. [Q8NEN0-1]
GeneIDi84071.
KEGGihsa:84071.
UCSCiuc003pss.6. human. [Q8NEN0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292499 mRNA. Translation: BAF85188.1. Different initiation.
AK294574 mRNA. Translation: BAG57766.1.
AL445189, AL390208 Genomic DNA. Translation: CAH71699.2.
AL390208, AL445189 Genomic DNA. Translation: CAI16717.2. Sequence problems.
CH471051 Genomic DNA. Translation: EAW48369.1.
BC030603 mRNA. Translation: AAH30603.2. Different initiation.
AL136754 mRNA. Translation: CAB66688.2.
CCDSiCCDS5069.2. [Q8NEN0-1]
CCDS69168.1. [Q8NEN0-2]
RefSeqiNP_001273538.1. NM_001286609.1. [Q8NEN0-2]
NP_115507.4. NM_032131.5. [Q8NEN0-1]
XP_005267211.1. XM_005267154.3. [Q8NEN0-1]
XP_005267212.1. XM_005267155.2. [Q8NEN0-1]
XP_005267214.1. XM_005267157.3. [Q8NEN0-2]
XP_006715636.1. XM_006715573.2. [Q8NEN0-1]
XP_006715637.1. XM_006715574.2. [Q8NEN0-2]
XP_011534468.1. XM_011536166.1. [Q8NEN0-1]
XP_011534474.1. XM_011536172.2. [Q8NEN0-2]
UniGeneiHs.645481.

3D structure databases

ProteinModelPortaliQ8NEN0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123866. 1 interactor.
IntActiQ8NEN0. 2 interactors.
MINTiMINT-4714556.
STRINGi9606.ENSP00000376417.

PTM databases

iPTMnetiQ8NEN0.
PhosphoSitePlusiQ8NEN0.

Polymorphism and mutation databases

DMDMi172045816.

Proteomic databases

EPDiQ8NEN0.
PaxDbiQ8NEN0.
PeptideAtlasiQ8NEN0.
PRIDEiQ8NEN0.

Protocols and materials databases

DNASUi84071.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368972; ENSP00000357968; ENSG00000118690. [Q8NEN0-2]
ENST00000392644; ENSP00000376417; ENSG00000118690. [Q8NEN0-1]
GeneIDi84071.
KEGGihsa:84071.
UCSCiuc003pss.6. human. [Q8NEN0-1]

Organism-specific databases

CTDi84071.
DisGeNETi84071.
GeneCardsiARMC2.
H-InvDBHIX0006121.
HGNCiHGNC:23045. ARMC2.
HPAiHPA025809.
HPA053696.
neXtProtiNX_Q8NEN0.
OpenTargetsiENSG00000118690.
PharmGKBiPA134943829.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUKI. Eukaryota.
ENOG410XPBC. LUCA.
GeneTreeiENSGT00390000000663.
HOGENOMiHOG000034054.
HOVERGENiHBG059194.
InParanoidiQ8NEN0.
OMAiMEAFLYC.
OrthoDBiEOG091G0I4Q.
PhylomeDBiQ8NEN0.
TreeFamiTF329012.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118690-MONOMER.

Miscellaneous databases

ChiTaRSiARMC2. human.
GenomeRNAii84071.
PROiQ8NEN0.

Gene expression databases

BgeeiENSG00000118690.
CleanExiHS_ARMC2.
ExpressionAtlasiQ8NEN0. baseline and differential.
GenevisibleiQ8NEN0. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
SMARTiSM00185. ARM. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiARMC2_HUMAN
AccessioniPrimary (citable) accession number: Q8NEN0
Secondary accession number(s): A8K8Y4
, B4DGF5, G5E993, Q5VVY8, Q9H0K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 18, 2008
Last modified: November 2, 2016
This is version 119 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.