ID SHCBP_HUMAN Reviewed; 672 AA. AC Q8NEM2; Q96N60; Q9BVS0; Q9H6P6; DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot. DT 20-DEC-2005, sequence version 2. DT 07-JUL-2009, entry version 52. DE RecName: Full=SHC SH2 domain-binding protein 1; GN Name=SHCBP1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Placenta, and Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, AND MASS RP SPECTROMETRY. RC TISSUE=Epithelium; RX PubMed=15302935; DOI=10.1073/pnas.0404720101; RA Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., RA Li J., Cohn M.A., Cantley L.C., Gygi S.P.; RT "Large-scale characterization of HeLa cell nuclear phosphoproteins."; RL Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). RN [4] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND MASS RP SPECTROMETRY. RC TISSUE=Epithelium; RX PubMed=16964243; DOI=10.1038/nbt1240; RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; RT "A probability-based approach for high-throughput protein RT phosphorylation analysis and site localization."; RL Nat. Biotechnol. 24:1285-1292(2006). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31; SER-42; SER-44; RP SER-47; SER-273 AND SER-634, AND MASS SPECTROMETRY. RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). CC -!- FUNCTION: May play a role in signaling pathways governing cellular CC proliferation, cell growth and differentiation. May be a component CC of a novel signaling pathway downstream of Shc (By similarity). CC -!- SUBUNIT: Interacts directly with isoform p52shc of SHC1 via its CC SH2 domain (By similarity). CC -!- INTERACTION: CC P61981:YWHAG; NbExp=1; IntAct=EBI-744700, EBI-359832; CC -!- SIMILARITY: Contains 5 PbH1 repeats. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AK025662; BAB15208.1; ALT_INIT; mRNA. DR EMBL; AK055931; BAB71049.1; -; mRNA. DR EMBL; BC000960; AAH00960.1; -; mRNA. DR EMBL; BC030699; AAH30699.1; -; mRNA. DR IPI; IPI00168691; -. DR RefSeq; NP_079021.3; -. DR UniGene; Hs.123253; -. DR IntAct; Q8NEM2; 2. DR PhosphoSite; Q8NEM2; -. DR PRIDE; Q8NEM2; -. DR Ensembl; ENSG00000171241; Homo sapiens. DR GeneID; 79801; -. DR KEGG; hsa:79801; -. DR UCSC; uc002eec.2; human. DR GeneCards; GC16M045171; -. DR HGNC; HGNC:29547; SHCBP1. DR MIM; 611027; gene. DR PharmGKB; PA134931125; -. DR HOGENOM; Q8NEM2; -. DR HOVERGEN; Q8NEM2; -. DR NextBio; 69364; -. DR ArrayExpress; Q8NEM2; -. DR Bgee; Q8NEM2; -. DR CleanEx; HS_SHCBP1; -. DR GermOnline; ENSG00000171241; Homo sapiens. DR InterPro; IPR006626; PbH1. DR SMART; SM00710; PbH1; 5. PE 1: Evidence at protein level; KW Complete proteome; Phosphoprotein; Polymorphism; Repeat. FT CHAIN 1 672 SHC SH2 domain-binding protein 1. FT /FTId=PRO_0000076315. FT REPEAT 428 451 PbH1 1. FT REPEAT 452 473 PbH1 2. FT REPEAT 474 496 PbH1 3. FT REPEAT 497 518 PbH1 4. FT REPEAT 526 548 PbH1 5. FT COMPBIAS 211 216 Poly-Glu. FT MOD_RES 31 31 Phosphoserine. FT MOD_RES 42 42 Phosphoserine. FT MOD_RES 44 44 Phosphoserine. FT MOD_RES 47 47 Phosphoserine. FT MOD_RES 273 273 Phosphoserine. FT MOD_RES 634 634 Phosphoserine. FT VARIANT 21 21 T -> M (in dbSNP:rs6598679). FT /FTId=VAR_051354. FT VARIANT 60 60 M -> R (in dbSNP:rs11545690). FT /FTId=VAR_051355. FT CONFLICT 118 118 V -> A (in Ref. 1; BAB71049). FT CONFLICT 329 329 Q -> R (in Ref. 1; BAB71049). FT CONFLICT 437 437 K -> R (in Ref. 1; BAB15208). FT CONFLICT 450 450 V -> A (in Ref. 1; BAB15208). FT CONFLICT 558 558 N -> S (in Ref. 2; AAH30699). SQ SEQUENCE 672 AA; 75660 MW; 564876E183EFCC2E CRC64; MADGSLTGGG LEAAAMAPER TGWAVEQELA SLEKGLFQDE DSCSDCSYRD KPGSSLQSFM PEGKTFFPEI FQTNQLLFYE RFRAYQDYIL ADCKASEVQE FTAEFLEKVL EPSGWRAVWH TNVFKVLVEI TDVDFAALKA VVRLAEPYLC DSQVSTFTME CMKELLDLKE HRLPLQELWV VFDDSGVFDQ TALAIEHVRF FYQNIWRSWD EEEEDEYDYF VRCVEPRLRL HYDILEDRVP SGLIVDYHNL LSQCEESYRK FLNLRSSLSN CNSDSEQENI SMVEGLKLYS EMEQLKQKLK LIENPLLRYV FGYQKNSNIQ AKGVRSSGQK ITHVVSSTMM AGLLRSLLTD RLCQEPGEEE REIQFHSDPL SAINACFEGD TVIVCPGHYV VHGTFSIADS IELEGYGLPD DIVIEKRGKG DTFVDCTGAD IKISGIKFVQ HDAVEGILIV HRGKTTLENC VLQCETTGVT VRTSAEFLMK NSDLYGAKGA GIEIYPGSQC TLSDNGIHHC KEGILIKDFL DEHYDIPKIS MVNNIIHNNE GYGVVLVKPT IFSDLQENAE DGTEENKALK IQTSGEPDVA ERVDLEELIE CATGKMELCA RTDPSEQVEG NCEIVNELIA ASTQKGQIKK KRLSELGITQ ADDNLMSQEM FVGIVGNQFK WNGKGSFGTF LF //