Reviewed, UniProtKB/Swiss-Prot Q8NEM2 (SHCBP_HUMAN)

Names and origin

Protein names

Recommended name:
    SHC SH2 domain-binding protein 1

Gene names

Name:

SHCBP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	672 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc By similarity.
Subunit structure	Interacts directly with isoform p52shc of SHC1 via its SH2 domain By similarity.
Sequence similarities	Contains 5 PbH1 repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
PTM	Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With	Entry	#Exp.	IntAct	Notes
YWHAG	P61981	1	EBI-744700,EBI-359832

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 672	672	SHC SH2 domain-binding protein 1		PRO_0000076315
Regions
	Repeat	428 – 451	24	PbH1 1
	Repeat	452 – 473	22	PbH1 2
	Repeat	474 – 496	23	PbH1 3
	Repeat	497 – 518	22	PbH1 4
	Repeat	526 – 548	23	PbH1 5
	Compositional bias	211 – 216	6	Poly-Glu
Amino acid modifications
	Modified residue	31	1	Phosphoserine Ref.4 Ref.5
	Modified residue	42	1	Phosphoserine Ref.5 Ref.3
	Modified residue	44	1	Phosphoserine Ref.5
	Modified residue	47	1	Phosphoserine Ref.5
	Modified residue	273	1	Phosphoserine Ref.5
	Modified residue	634	1	Phosphoserine Ref.5
Natural variations
	Natural variant	21	1	T → M: dbSNP rs6598679.		VAR_051354
	Natural variant	60	1	M → R: dbSNP rs11545690.		VAR_051355
Experimental info
	Sequence conflict	118	1	V → A in BAB71049. Ref.1
	Sequence conflict	329	1	Q → R in BAB71049. Ref.1
	Sequence conflict	437	1	K → R in BAB15208. Ref.1
	Sequence conflict	450	1	V → A in BAB15208. Ref.1
	Sequence conflict	558	1	N → S in AAH30699. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8NEM2-1 [UniParc]. Last modified December 20, 2005. Version 2. Checksum: 564876E183EFCC2E	FASTA	672	75,660
	10 20 30 40 50 60 MADGSLTGGG LEAAAMAPER TGWAVEQELA SLEKGLFQDE DSCSDCSYRD KPGSSLQSFM 70 80 90 100 110 120 PEGKTFFPEI FQTNQLLFYE RFRAYQDYIL ADCKASEVQE FTAEFLEKVL EPSGWRAVWH 130 140 150 160 170 180 TNVFKVLVEI TDVDFAALKA VVRLAEPYLC DSQVSTFTME CMKELLDLKE HRLPLQELWV 190 200 210 220 230 240 VFDDSGVFDQ TALAIEHVRF FYQNIWRSWD EEEEDEYDYF VRCVEPRLRL HYDILEDRVP 250 260 270 280 290 300 SGLIVDYHNL LSQCEESYRK FLNLRSSLSN CNSDSEQENI SMVEGLKLYS EMEQLKQKLK 310 320 330 340 350 360 LIENPLLRYV FGYQKNSNIQ AKGVRSSGQK ITHVVSSTMM AGLLRSLLTD RLCQEPGEEE 370 380 390 400 410 420 REIQFHSDPL SAINACFEGD TVIVCPGHYV VHGTFSIADS IELEGYGLPD DIVIEKRGKG 430 440 450 460 470 480 DTFVDCTGAD IKISGIKFVQ HDAVEGILIV HRGKTTLENC VLQCETTGVT VRTSAEFLMK 490 500 510 520 530 540 NSDLYGAKGA GIEIYPGSQC TLSDNGIHHC KEGILIKDFL DEHYDIPKIS MVNNIIHNNE 550 560 570 580 590 600 GYGVVLVKPT IFSDLQENAE DGTEENKALK IQTSGEPDVA ERVDLEELIE CATGKMELCA 610 620 630 640 650 660 RTDPSEQVEG NCEIVNELIA ASTQKGQIKK KRLSELGITQ ADDNLMSQEM FVGIVGNQFK 670 WNGKGSFGTF LF

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta and Testis.
[3]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, MASS SPECTROMETRY. Tissue: Epithelium.
[4]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, MASS SPECTROMETRY. Tissue: Epithelium.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31; SER-42; SER-44; SER-47; SER-273 AND SER-634, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK025662 mRNA. Translation: BAB15208.1. Different initiation. AK055931 mRNA. Translation: BAB71049.1. BC000960 mRNA. Translation: AAH00960.1. BC030699 mRNA. Translation: AAH30699.1.
IPI	IPI00168691.
RefSeq	NP_079021.3.
UniGene	Hs.123253
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NEM2. 2 interactions.
PTM databases
PhosphoSite	Q8NEM2.
Proteomic databases
PRIDE	Q8NEM2.
Genome annotation databases
Ensembl	ENSG00000171241. Homo sapiens. [Contig view]
GeneID	79801.
KEGG	hsa:79801.
Organism-specific databases
GeneCards	GC16M045171.
HGNC	HGNC:29547. SHCBP1.
MIM	611027. gene.
PharmGKB	PA134931125.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8NEM2.
HOVERGEN	Q8NEM2.
Gene expression databases
ArrayExpress	Q8NEM2.
Bgee	Q8NEM2.
CleanEx	HS_SHCBP1.
GermOnline	ENSG00000171241. Homo sapiens.
Family and domain databases
InterPro	IPR006626. PbH1. [Graphical view]
SMART	SM00710. PbH1. 5 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	69364.
SOURCE	Search...

Entry information

Entry name

SHCBP_HUMAN

Accession

Primary (citable) accession number: Q8NEM2
Secondary accession number(s): Q96N60, Q9BVS0, Q9H6P6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 20, 2005
Last modified:	February 10, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)