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Protein

SHC SH2 domain-binding protein 1

Gene

SHCBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171241-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SHC SH2 domain-binding protein 1
Gene namesi
Name:SHCBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29547. SHCBP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi79801.
OpenTargetsiENSG00000171241.
PharmGKBiPA134931125.

Polymorphism and mutation databases

BioMutaiSHCBP1.
DMDMi296452958.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000763152 – 672SHC SH2 domain-binding protein 1Add BLAST671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Modified residuei7PhosphothreonineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8NEM2.
MaxQBiQ8NEM2.
PaxDbiQ8NEM2.
PeptideAtlasiQ8NEM2.
PRIDEiQ8NEM2.

PTM databases

iPTMnetiQ8NEM2.
PhosphoSitePlusiQ8NEM2.

Expressioni

Gene expression databases

BgeeiENSG00000171241.
CleanExiHS_SHCBP1.
ExpressionAtlasiQ8NEM2. baseline and differential.
GenevisibleiQ8NEM2. HS.

Organism-specific databases

HPAiHPA048876.

Interactioni

Subunit structurei

Interacts directly with isoform p52shc of SHC1 via its SH2 domain (By similarity). Interacts with TRIM71; leading to enhanced SHCBP1 protein stability (By similarity). Interacts with both members of the centralspindlin complex, KIF23 and RACGAP1 (PubMed:21187330).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PRKCBP057712EBI-744700,EBI-706216

Protein-protein interaction databases

BioGridi122898. 31 interactors.
IntActiQ8NEM2. 12 interactors.
MINTiMINT-1450223.
STRINGi9606.ENSP00000306473.

Structurei

3D structure databases

ProteinModelPortaliQ8NEM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati428 – 451PbH1 1Add BLAST24
Repeati452 – 473PbH1 2Add BLAST22
Repeati474 – 496PbH1 3Add BLAST23
Repeati497 – 518PbH1 4Add BLAST22
Repeati526 – 548PbH1 5Add BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 216Poly-Glu6

Sequence similaritiesi

Contains 5 PbH1 repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIV2. Eukaryota.
ENOG410XXTE. LUCA.
GeneTreeiENSGT00530000063807.
HOGENOMiHOG000154313.
HOVERGENiHBG060212.
InParanoidiQ8NEM2.
OMAiPERTGWA.
OrthoDBiEOG091G0UP6.
PhylomeDBiQ8NEM2.
TreeFamiTF329196.

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
InterProiIPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
SMARTiSM00710. PbH1. 5 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NEM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGSLTGGG LEAAAMAPER MGWAVEQELA SLEKGLFQDE DSCSDCSYRD
60 70 80 90 100
KPGSSLQSFM PEGKTFFPEI FQTNQLLFYE RFRAYQDYIL ADCKASEVQE
110 120 130 140 150
FTAEFLEKVL EPSGWRAVWH TNVFKVLVEI TDVDFAALKA VVRLAEPYLC
160 170 180 190 200
DSQVSTFTME CMKELLDLKE HRLPLQELWV VFDDSGVFDQ TALAIEHVRF
210 220 230 240 250
FYQNIWRSWD EEEEDEYDYF VRCVEPRLRL HYDILEDRVP SGLIVDYHNL
260 270 280 290 300
LSQCEESYRK FLNLRSSLSN CNSDSEQENI SMVEGLKLYS EMEQLKQKLK
310 320 330 340 350
LIENPLLRYV FGYQKNSNIQ AKGVRSSGQK ITHVVSSTMM AGLLRSLLTD
360 370 380 390 400
RLCQEPGEEE REIQFHSDPL SAINACFEGD TVIVCPGHYV VHGTFSIADS
410 420 430 440 450
IELEGYGLPD DIVIEKRGKG DTFVDCTGAD IKISGIKFVQ HDAVEGILIV
460 470 480 490 500
HRGKTTLENC VLQCETTGVT VRTSAEFLMK NSDLYGAKGA GIEIYPGSQC
510 520 530 540 550
TLSDNGIHHC KEGILIKDFL DEHYDIPKIS MVNNIIHNNE GYGVVLVKPT
560 570 580 590 600
IFSDLQENAE DGTEENKALK IQTSGEPDVA ERVDLEELIE CATGKMELCA
610 620 630 640 650
RTDPSEQVEG NCEIVNELIA ASTQKGQIKK KRLSELGITQ ADDNLMSQEM
660 670
FVGIVGNQFK WNGKGSFGTF LF
Length:672
Mass (Da):75,690
Last modified:May 18, 2010 - v3
Checksum:iF3BF0210D5413376
GO

Sequence cautioni

The sequence BAB15208 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118V → A in BAB71049 (PubMed:14702039).Curated1
Sequence conflicti329Q → R in BAB71049 (PubMed:14702039).Curated1
Sequence conflicti437K → R in BAB15208 (PubMed:14702039).Curated1
Sequence conflicti450V → A in BAB15208 (PubMed:14702039).Curated1
Sequence conflicti558N → S in AAH30699 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05135421M → T.Combined sources2 PublicationsCorresponds to variant rs6598679dbSNPEnsembl.1
Natural variantiVAR_05135560M → R.Corresponds to variant rs11545690dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025662 mRNA. Translation: BAB15208.1. Different initiation.
AK055931 mRNA. Translation: BAB71049.1.
AC092368 Genomic DNA. No translation available.
BC000960 mRNA. Translation: AAH00960.1.
BC030699 mRNA. Translation: AAH30699.1.
CCDSiCCDS10720.1.
RefSeqiNP_079021.3. NM_024745.4.
UniGeneiHs.123253.

Genome annotation databases

EnsembliENST00000303383; ENSP00000306473; ENSG00000171241.
GeneIDi79801.
KEGGihsa:79801.
UCSCiuc002eec.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025662 mRNA. Translation: BAB15208.1. Different initiation.
AK055931 mRNA. Translation: BAB71049.1.
AC092368 Genomic DNA. No translation available.
BC000960 mRNA. Translation: AAH00960.1.
BC030699 mRNA. Translation: AAH30699.1.
CCDSiCCDS10720.1.
RefSeqiNP_079021.3. NM_024745.4.
UniGeneiHs.123253.

3D structure databases

ProteinModelPortaliQ8NEM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122898. 31 interactors.
IntActiQ8NEM2. 12 interactors.
MINTiMINT-1450223.
STRINGi9606.ENSP00000306473.

PTM databases

iPTMnetiQ8NEM2.
PhosphoSitePlusiQ8NEM2.

Polymorphism and mutation databases

BioMutaiSHCBP1.
DMDMi296452958.

Proteomic databases

EPDiQ8NEM2.
MaxQBiQ8NEM2.
PaxDbiQ8NEM2.
PeptideAtlasiQ8NEM2.
PRIDEiQ8NEM2.

Protocols and materials databases

DNASUi79801.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303383; ENSP00000306473; ENSG00000171241.
GeneIDi79801.
KEGGihsa:79801.
UCSCiuc002eec.5. human.

Organism-specific databases

CTDi79801.
DisGeNETi79801.
GeneCardsiSHCBP1.
HGNCiHGNC:29547. SHCBP1.
HPAiHPA048876.
MIMi611027. gene.
neXtProtiNX_Q8NEM2.
OpenTargetsiENSG00000171241.
PharmGKBiPA134931125.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIV2. Eukaryota.
ENOG410XXTE. LUCA.
GeneTreeiENSGT00530000063807.
HOGENOMiHOG000154313.
HOVERGENiHBG060212.
InParanoidiQ8NEM2.
OMAiPERTGWA.
OrthoDBiEOG091G0UP6.
PhylomeDBiQ8NEM2.
TreeFamiTF329196.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171241-MONOMER.

Miscellaneous databases

ChiTaRSiSHCBP1. human.
GeneWikiiSHCBP1.
GenomeRNAii79801.
PROiQ8NEM2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171241.
CleanExiHS_SHCBP1.
ExpressionAtlasiQ8NEM2. baseline and differential.
GenevisibleiQ8NEM2. HS.

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
InterProiIPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
SMARTiSM00710. PbH1. 5 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSHCBP_HUMAN
AccessioniPrimary (citable) accession number: Q8NEM2
Secondary accession number(s): Q96N60, Q9BVS0, Q9H6P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.