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Protein

Zinc finger protein 680

Gene

ZNF680

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri182 – 20423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri210 – 23223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri238 – 26023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri266 – 28823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri294 – 31623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri322 – 34423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri350 – 37223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri378 – 40023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri406 – 42823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri434 – 45623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri462 – 48423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri490 – 51223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 680
Gene namesi
Name:ZNF680
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:26897. ZNF680.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670481.

Polymorphism and mutation databases

BioMutaiZNF680.
DMDMi116242865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Zinc finger protein 680PRO_0000234000Add
BLAST

Proteomic databases

EPDiQ8NEM1.
PaxDbiQ8NEM1.
PeptideAtlasiQ8NEM1.
PRIDEiQ8NEM1.

PTM databases

iPTMnetiQ8NEM1.
PhosphoSiteiQ8NEM1.

Expressioni

Gene expression databases

BgeeiQ8NEM1.
CleanExiHS_ZNF680.
GenevisibleiQ8NEM1. HS.

Organism-specific databases

HPAiHPA003173.

Interactioni

Protein-protein interaction databases

IntActiQ8NEM1. 1 interaction.
STRINGi9606.ENSP00000309330.

Structurei

3D structure databases

ProteinModelPortaliQ8NEM1.
SMRiQ8NEM1. Positions 6-61, 152-520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 8472KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri182 – 20423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri210 – 23223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri238 – 26023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri266 – 28823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri294 – 31623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri322 – 34423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri350 – 37223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri378 – 40023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri406 – 42823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri434 – 45623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri462 – 48423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri490 – 51223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000231475.
HOVERGENiHBG018163.
InParanoidiQ8NEM1.
KOiK09228.
OMAiNWFSELI.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8NEM1.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NEM1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGPPGSLEM GPLTFRDVAI EFSLEEWQCL DTAQRNLYRK VMFENYRNLV
60 70 80 90 100
FLGIAVSKPH LITCLEQGKE PWNRKRQEMV AKPPVIYSHF TEDLWPEHSI
110 120 130 140 150
KDSFQKVILR GYGKCGHENL QLRISCKSVD ESKVFKEGYN ELNQCLRTTQ
160 170 180 190 200
SKIFQCDKYV KVFHKFSNSN SHKKRNTGKK VFKCKECGKS FCMLSHLTQH
210 220 230 240 250
IRIHTRENSY KCEECGKVLN WFSELIKHKG IHMGEKPYKC EECGKAFNQS
260 270 280 290 300
STLIKHKKIH IEEKPFKCEE CGKAFSLFSI LSKHKIIHTG DKPYKCDECH
310 320 330 340 350
KAFNWFATLT NHKRIHTGEK PFKCEECGKD FNQFSNLTKH KKIHTGEKPY
360 370 380 390 400
KCEECGKAFN QFANLTRHKK IHTGEKSYKC EECGKAFIQS SNLTEHMRIH
410 420 430 440 450
TGEKPYKCEE CGKAFNGCSS LTRHKRIHTR ENTYKCEECG KGFTLFSTLT
460 470 480 490 500
NHKVIHTGEK SYKCDECGNV FNWPATLANH KRIHAREKPY KCEECGKAFN
510 520 530
RSSHLTRHKK IHTGEKLYKP EKCDNNFDNT
Length:530
Mass (Da):61,798
Last modified:October 17, 2006 - v2
Checksum:iBB9AC6FFA50B0A04
GO
Isoform 2 (identifier: Q8NEM1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-123: VIYSHFTEDL...KCGHENLQLR → ESYCVAQADL...RNNPLCQATM
     124-530: Missing.

Note: No experimental confirmation available.
Show »
Length:123
Mass (Da):14,143
Checksum:i016D88839AC1C1FC
GO

Sequence cautioni

The sequence BAC11286.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti132 – 1321S → F.
Corresponds to variant rs11768951 [ dbSNP | Ensembl ].
VAR_027892
Natural varianti330 – 3301D → G.1 Publication
Corresponds to variant rs17856885 [ dbSNP | Ensembl ].
VAR_027893
Natural varianti525 – 5251N → D.1 Publication
Corresponds to variant rs17852813 [ dbSNP | Ensembl ].
VAR_027894

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei85 – 12339VIYSH…NLQLR → ESYCVAQADLELLVSSYLTA LASLKMWDYRNNPLCQATM in isoform 2. 1 PublicationVSP_043114Add
BLAST
Alternative sequencei124 – 530407Missing in isoform 2. 1 PublicationVSP_043115Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074911 mRNA. Translation: BAC11286.1. Different initiation.
AK122937 mRNA. Translation: BAG53806.1.
AK131240 mRNA. Translation: BAD18422.1.
AC016769 Genomic DNA. No translation available.
CH471204 Genomic DNA. Translation: EAW77970.1.
CH471204 Genomic DNA. Translation: EAW77971.1.
BC030700 mRNA. Translation: AAH30700.1.
CCDSiCCDS34644.1. [Q8NEM1-1]
CCDS47594.1. [Q8NEM1-2]
RefSeqiNP_001123494.1. NM_001130022.1. [Q8NEM1-2]
NP_848653.2. NM_178558.4. [Q8NEM1-1]
XP_011514420.1. XM_011516118.1.
UniGeneiHs.520886.

Genome annotation databases

EnsembliENST00000309683; ENSP00000309330; ENSG00000173041. [Q8NEM1-1]
ENST00000447137; ENSP00000393506; ENSG00000173041. [Q8NEM1-2]
GeneIDi340252.
KEGGihsa:340252.
UCSCiuc003tta.3. human. [Q8NEM1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074911 mRNA. Translation: BAC11286.1. Different initiation.
AK122937 mRNA. Translation: BAG53806.1.
AK131240 mRNA. Translation: BAD18422.1.
AC016769 Genomic DNA. No translation available.
CH471204 Genomic DNA. Translation: EAW77970.1.
CH471204 Genomic DNA. Translation: EAW77971.1.
BC030700 mRNA. Translation: AAH30700.1.
CCDSiCCDS34644.1. [Q8NEM1-1]
CCDS47594.1. [Q8NEM1-2]
RefSeqiNP_001123494.1. NM_001130022.1. [Q8NEM1-2]
NP_848653.2. NM_178558.4. [Q8NEM1-1]
XP_011514420.1. XM_011516118.1.
UniGeneiHs.520886.

3D structure databases

ProteinModelPortaliQ8NEM1.
SMRiQ8NEM1. Positions 6-61, 152-520.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8NEM1. 1 interaction.
STRINGi9606.ENSP00000309330.

PTM databases

iPTMnetiQ8NEM1.
PhosphoSiteiQ8NEM1.

Polymorphism and mutation databases

BioMutaiZNF680.
DMDMi116242865.

Proteomic databases

EPDiQ8NEM1.
PaxDbiQ8NEM1.
PeptideAtlasiQ8NEM1.
PRIDEiQ8NEM1.

Protocols and materials databases

DNASUi340252.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309683; ENSP00000309330; ENSG00000173041. [Q8NEM1-1]
ENST00000447137; ENSP00000393506; ENSG00000173041. [Q8NEM1-2]
GeneIDi340252.
KEGGihsa:340252.
UCSCiuc003tta.3. human. [Q8NEM1-1]

Organism-specific databases

CTDi340252.
GeneCardsiZNF680.
HGNCiHGNC:26897. ZNF680.
HPAiHPA003173.
neXtProtiNX_Q8NEM1.
PharmGKBiPA142670481.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000231475.
HOVERGENiHBG018163.
InParanoidiQ8NEM1.
KOiK09228.
OMAiNWFSELI.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8NEM1.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii340252.
PROiQ8NEM1.

Gene expression databases

BgeeiQ8NEM1.
CleanExiHS_ZNF680.
GenevisibleiQ8NEM1. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Teratocarcinoma and Testis.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLY-330 AND ASP-525.
    Tissue: Testis.

Entry informationi

Entry nameiZN680_HUMAN
AccessioniPrimary (citable) accession number: Q8NEM1
Secondary accession number(s): B3KVJ4, Q6ZNF3, Q8NC79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 17, 2006
Last modified: July 6, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.