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Protein

Coiled-coil domain-containing protein 54

Gene

CCDC54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138483-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 54
Alternative name(s):
Testis development protein NYD-SP17
Gene namesi
Name:CCDC54
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30703. CCDC54.

Pathology & Biotechi

Organism-specific databases

DisGeNETi84692.
OpenTargetsiENSG00000138483.
PharmGKBiPA142672170.

Polymorphism and mutation databases

BioMutaiCCDC54.
DMDMi147637038.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002866681 – 328Coiled-coil domain-containing protein 54Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei182PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8NEL0.
PeptideAtlasiQ8NEL0.
PRIDEiQ8NEL0.

PTM databases

iPTMnetiQ8NEL0.
PhosphoSitePlusiQ8NEL0.

Expressioni

Gene expression databases

BgeeiENSG00000138483.
CleanExiHS_CCDC54.
ExpressionAtlasiQ8NEL0. baseline and differential.
GenevisibleiQ8NEL0. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000261058.

Structurei

3D structure databases

ProteinModelPortaliQ8NEL0.
SMRiQ8NEL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili93 – 151Sequence analysisAdd BLAST59

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIYS. Eukaryota.
ENOG41116C5. LUCA.
GeneTreeiENSGT00390000008948.
HOGENOMiHOG000111421.
HOVERGENiHBG096794.
InParanoidiQ8NEL0.
OMAiKLTFVHG.
OrthoDBiEOG091G1BRY.
PhylomeDBiQ8NEL0.
TreeFamiTF338361.

Sequencei

Sequence statusi: Complete.

Q8NEL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTLHTKRVK AAARQMWTSN LSKVRQSLKN VYHKCKIRHQ DSTGYPTVTS
60 70 80 90 100
DDCNQDDDSY DGKMNLPVVL QDVKTAQVEL FSQMTDIVHM IPKVQEKTDL
110 120 130 140 150
YQKQMEVLET RMNVNEDKQC TTTKDILSMK EDIKALKKKV TELEIQNSCS
160 170 180 190 200
TIHCLEILEG ERGKEITELL YKLIQPATLK NTLASTDMEI SSAEPEKVPS
210 220 230 240 250
YPKSTDHLEK KTISPQMKTL KKRNHQNASR SFEKAKPNIY IYPDFSTWIK
260 270 280 290 300
LTFVHGGKWT FFLSATKLEE FIQWLLSRPT ILPEEPQVIT QRYCPFTGPI
310 320
LSLTTICLSI FNNIYGFICS LKEEVTRL
Length:328
Mass (Da):37,886
Last modified:May 15, 2007 - v2
Checksum:i238D593D97AF3D11
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03215138R → Q.1 PublicationCorresponds to variant rs709564dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367469 mRNA. Translation: AAK53405.1.
AK058091 mRNA. Translation: BAB71661.1.
BC030780 mRNA. Translation: AAH30780.1.
CCDSiCCDS2949.1.
RefSeqiNP_115989.1. NM_032600.2.
UniGeneiHs.164799.

Genome annotation databases

EnsembliENST00000261058; ENSP00000261058; ENSG00000138483.
GeneIDi84692.
KEGGihsa:84692.
UCSCiuc003dwi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367469 mRNA. Translation: AAK53405.1.
AK058091 mRNA. Translation: BAB71661.1.
BC030780 mRNA. Translation: AAH30780.1.
CCDSiCCDS2949.1.
RefSeqiNP_115989.1. NM_032600.2.
UniGeneiHs.164799.

3D structure databases

ProteinModelPortaliQ8NEL0.
SMRiQ8NEL0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000261058.

PTM databases

iPTMnetiQ8NEL0.
PhosphoSitePlusiQ8NEL0.

Polymorphism and mutation databases

BioMutaiCCDC54.
DMDMi147637038.

Proteomic databases

PaxDbiQ8NEL0.
PeptideAtlasiQ8NEL0.
PRIDEiQ8NEL0.

Protocols and materials databases

DNASUi84692.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261058; ENSP00000261058; ENSG00000138483.
GeneIDi84692.
KEGGihsa:84692.
UCSCiuc003dwi.2. human.

Organism-specific databases

CTDi84692.
DisGeNETi84692.
GeneCardsiCCDC54.
HGNCiHGNC:30703. CCDC54.
neXtProtiNX_Q8NEL0.
OpenTargetsiENSG00000138483.
PharmGKBiPA142672170.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIYS. Eukaryota.
ENOG41116C5. LUCA.
GeneTreeiENSGT00390000008948.
HOGENOMiHOG000111421.
HOVERGENiHBG096794.
InParanoidiQ8NEL0.
OMAiKLTFVHG.
OrthoDBiEOG091G1BRY.
PhylomeDBiQ8NEL0.
TreeFamiTF338361.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138483-MONOMER.

Miscellaneous databases

GenomeRNAii84692.
PROiQ8NEL0.

Gene expression databases

BgeeiENSG00000138483.
CleanExiHS_CCDC54.
ExpressionAtlasiQ8NEL0. baseline and differential.
GenevisibleiQ8NEL0. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCCD54_HUMAN
AccessioniPrimary (citable) accession number: Q8NEL0
Secondary accession number(s): Q96A43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 30, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.