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Protein

Zinc finger protein 548

Gene

ZNF548

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri197 – 21923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri477 – 49923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 548
Gene namesi
Name:ZNF548
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26561. ZNF548.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134889718.

Polymorphism and mutation databases

BioMutaiZNF548.
DMDMi296453046.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Zinc finger protein 548PRO_0000242160Add
BLAST

Proteomic databases

MaxQBiQ8NEK5.
PaxDbiQ8NEK5.
PRIDEiQ8NEK5.

PTM databases

iPTMnetiQ8NEK5.
PhosphoSiteiQ8NEK5.

Expressioni

Gene expression databases

BgeeiQ8NEK5.
CleanExiHS_ZNF548.
ExpressionAtlasiQ8NEK5. baseline and differential.
GenevisibleiQ8NEK5. HS.

Organism-specific databases

HPAiHPA066042.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000337555.

Structurei

3D structure databases

ProteinModelPortaliQ8NEK5.
SMRiQ8NEK5. Positions 115-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri197 – 21923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri477 – 49923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8NEK5.
KOiK09228.
OMAiFMKHQTV.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8NEK5.
TreeFamiTF339848.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NEK5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLTEGRVVF EDVAIYFSQE EWGHLDEAQR LLYRDVMLEN LALLSSLGSW
60 70 80 90 100
HGAEDEEAPS QQGFSVGVSE VTASKPCLSS QKVHPSETCG PPLKDILCLV
110 120 130 140 150
EHNGIHPEQH IYICEAELFQ HPKQQIGENL SRGDDWIPSF GKNHRVHMAE
160 170 180 190 200
EIFTCMEGWK DLPATSCLLQ HQGPQSEWKP YRDTEDREAF QTGQNDYKCS
210 220 230 240 250
ECGKTFTCSY SFVEHQKIHT GERSYECNKC GKFFKYSANF MKHQTVHTSE
260 270 280 290 300
RTYECRECGK SFMYNYRLMR HKRVHTGERP YECNTCGKFF RYSSTFVRHQ
310 320 330 340 350
RVHTGERPYE CRECGKFFMD SSTLIKHQRV HTGERPYKCN DCGKFFRYIS
360 370 380 390 400
TLIRHQRIHT GERPYECSVC GELFRYNSSL VKHWRNHTGE RPYKCSECGK
410 420 430 440 450
SFRYHCRLIR HQRVHTGERP YECSECGKFF RYNSNLIKHW RNHTGERPYE
460 470 480 490 500
CRECGKAFSH KHILVEHQKI HSGERPYECS ECQKAFIRKS HLVHHQKIHS
510 520 530
EERLVCSMNV GNSLAKTPTS LNIRDFTMEK VYH
Length:533
Mass (Da):62,728
Last modified:May 18, 2010 - v2
Checksum:iBFC3DDE9C74E0C98
GO
Isoform 2 (identifier: Q8NEK5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-6: G → GPLAMAEMDPTQG

Note: No experimental confirmation available.
Show »
Length:545
Mass (Da):63,970
Checksum:i9C46D313C634DFF5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti377 – 3771N → S in BAB71509 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581A → S.1 Publication
Corresponds to variant rs17856896 [ dbSNP | Ensembl ].
VAR_026845
Natural varianti73 – 731A → T.2 Publications
Corresponds to variant rs4801478 [ dbSNP | Ensembl ].
VAR_026846

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei6 – 61G → GPLAMAEMDPTQG in isoform 2. 1 PublicationVSP_019453

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003002 Genomic DNA. No translation available.
BC030788 mRNA. Translation: AAH30788.1.
AK057494 mRNA. Translation: BAB71509.1.
CCDSiCCDS46209.1. [Q8NEK5-1]
CCDS54324.1. [Q8NEK5-2]
RefSeqiNP_001166244.1. NM_001172773.1. [Q8NEK5-2]
NP_690873.2. NM_152909.3. [Q8NEK5-1]
UniGeneiHs.126905.

Genome annotation databases

EnsembliENST00000336128; ENSP00000337555; ENSG00000188785. [Q8NEK5-2]
ENST00000366197; ENSP00000379482; ENSG00000188785. [Q8NEK5-1]
GeneIDi147694.
KEGGihsa:147694.
UCSCiuc002qom.4. human. [Q8NEK5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003002 Genomic DNA. No translation available.
BC030788 mRNA. Translation: AAH30788.1.
AK057494 mRNA. Translation: BAB71509.1.
CCDSiCCDS46209.1. [Q8NEK5-1]
CCDS54324.1. [Q8NEK5-2]
RefSeqiNP_001166244.1. NM_001172773.1. [Q8NEK5-2]
NP_690873.2. NM_152909.3. [Q8NEK5-1]
UniGeneiHs.126905.

3D structure databases

ProteinModelPortaliQ8NEK5.
SMRiQ8NEK5. Positions 115-500.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000337555.

PTM databases

iPTMnetiQ8NEK5.
PhosphoSiteiQ8NEK5.

Polymorphism and mutation databases

BioMutaiZNF548.
DMDMi296453046.

Proteomic databases

MaxQBiQ8NEK5.
PaxDbiQ8NEK5.
PRIDEiQ8NEK5.

Protocols and materials databases

DNASUi147694.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336128; ENSP00000337555; ENSG00000188785. [Q8NEK5-2]
ENST00000366197; ENSP00000379482; ENSG00000188785. [Q8NEK5-1]
GeneIDi147694.
KEGGihsa:147694.
UCSCiuc002qom.4. human. [Q8NEK5-1]

Organism-specific databases

CTDi147694.
GeneCardsiZNF548.
HGNCiHGNC:26561. ZNF548.
HPAiHPA066042.
neXtProtiNX_Q8NEK5.
PharmGKBiPA134889718.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8NEK5.
KOiK09228.
OMAiFMKHQTV.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8NEK5.
TreeFamiTF339848.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF548. human.
GenomeRNAii147694.
NextBioi85687.
PROiQ8NEK5.

Gene expression databases

BgeeiQ8NEK5.
CleanExiHS_ZNF548.
ExpressionAtlasiQ8NEK5. baseline and differential.
GenevisibleiQ8NEK5. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-58 AND THR-73.
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-528 (ISOFORM 2), VARIANT THR-73.
    Tissue: Testis.

Entry informationi

Entry nameiZN548_HUMAN
AccessioniPrimary (citable) accession number: Q8NEK5
Secondary accession number(s): Q96M05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 18, 2010
Last modified: March 16, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.