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Protein

Neuroguidin

Gene

NGDN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs.By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroguidin
Alternative name(s):
Centromere accumulated nuclear protein 1
Short name:
CANu1
EIF4E-binding protein
Gene namesi
Name:NGDN
Synonyms:C14orf120
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20271. NGDN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Centromere, Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134957933.

Polymorphism and mutation databases

BioMutaiNGDN.
DMDMi46395905.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 315314NeuroguidinPRO_0000114331Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei121 – 1211PhosphoserineCombined sources
Modified residuei142 – 1421PhosphoserineCombined sources
Modified residuei143 – 1431PhosphoserineCombined sources
Modified residuei204 – 2041PhosphoserineCombined sources
Modified residuei214 – 2141PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8NEJ9.
MaxQBiQ8NEJ9.
PaxDbiQ8NEJ9.
PeptideAtlasiQ8NEJ9.
PRIDEiQ8NEJ9.
TopDownProteomicsiQ8NEJ9-1. [Q8NEJ9-1]

PTM databases

iPTMnetiQ8NEJ9.
PhosphoSiteiQ8NEJ9.

Expressioni

Gene expression databases

BgeeiENSG00000129460.
CleanExiHS_NGDN.
ExpressionAtlasiQ8NEJ9. baseline and differential.
GenevisibleiQ8NEJ9. HS.

Organism-specific databases

HPAiHPA000944.

Interactioni

Subunit structurei

Interacts with CPEB1 and EIF4E.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AATFQ9NY613EBI-9995414,EBI-372428

Protein-protein interaction databases

BioGridi117466. 20 interactions.
IntActiQ8NEJ9. 7 interactions.
MINTiMINT-3042536.
STRINGi9606.ENSP00000386134.

Structurei

3D structure databases

ProteinModelPortaliQ8NEJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 174134Necessary for interaction with EIF4EBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili13 – 4129Sequence analysisAdd
BLAST
Coiled coili181 – 20525Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SAS10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3117. Eukaryota.
ENOG4111F0Z. LUCA.
GeneTreeiENSGT00500000044922.
HOGENOMiHOG000013129.
HOVERGENiHBG082025.
InParanoidiQ8NEJ9.
KOiK14765.
OMAiMDLTHLI.
OrthoDBiEOG091G0I9S.
PhylomeDBiQ8NEJ9.
TreeFamiTF313713.

Family and domain databases

InterProiIPR007146. Sas10/Utp3/C1D.
[Graphical view]
PfamiPF04000. Sas10_Utp3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NEJ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALGVLESD LPSAVTLLKN LQEQVMAVTA QVKSLTQKVQ AGAYPTEKGL
60 70 80 90 100
SFLEVKDQLL LMYLMDLTHL ILDKASGGSL QGHDAVLRLV EIRTVLEKLR
110 120 130 140 150
PLDQKLKYQI DKLIKTAVTG SLSENDPLRF KPHPSNMMSK LSSEDEEEDE
160 170 180 190 200
AEDDQSEASG KKSVKGVSKK YVPPRLVPVH YDETEAEREK KRLERAKRRA
210 220 230 240 250
LSSSVIRELK EQYSDAPEEI RDARHPHVTR QSQEDQHRIN YEESMMVRLS
260 270 280 290 300
VSKREKGRRK RANVMSSQLH SLTHFSDISA LTGGTVHLDE DQNPIKKRKK
310
IPQKGRKKKG FRRRR
Length:315
Mass (Da):35,894
Last modified:October 1, 2002 - v1
Checksum:iF5B26C3C2EDDC840
GO
Isoform 2 (identifier: Q8NEJ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     311-311: F → Q
     312-315: Missing.

Note: May be due to a competing donor splice site.
Show »
Length:311
Mass (Da):35,250
Checksum:iF1CDC840E2968036
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151V → L.
Corresponds to variant rs10149626 [ dbSNP | Ensembl ].
VAR_051898
Natural varianti308 – 3081K → I.
Corresponds to variant rs17093050 [ dbSNP | Ensembl ].
VAR_051899

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei311 – 3111F → Q in isoform 2. 1 PublicationVSP_009935
Alternative sequencei312 – 3154Missing in isoform 2. 1 PublicationVSP_009936

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291875 mRNA. Translation: BAF84564.1.
AL050003 mRNA. Translation: CAB43232.2.
CH471078 Genomic DNA. Translation: EAW66149.1.
BC030817 mRNA. Translation: AAH30817.1.
CCDSiCCDS32051.1. [Q8NEJ9-2]
CCDS41926.1. [Q8NEJ9-1]
PIRiT08694.
RefSeqiNP_001036100.1. NM_001042635.1. [Q8NEJ9-1]
NP_056329.1. NM_015514.1. [Q8NEJ9-2]
UniGeneiHs.9043.

Genome annotation databases

EnsembliENST00000397154; ENSP00000380340; ENSG00000129460. [Q8NEJ9-2]
ENST00000408901; ENSP00000386134; ENSG00000129460. [Q8NEJ9-1]
GeneIDi25983.
KEGGihsa:25983.
UCSCiuc001wjy.4. human. [Q8NEJ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291875 mRNA. Translation: BAF84564.1.
AL050003 mRNA. Translation: CAB43232.2.
CH471078 Genomic DNA. Translation: EAW66149.1.
BC030817 mRNA. Translation: AAH30817.1.
CCDSiCCDS32051.1. [Q8NEJ9-2]
CCDS41926.1. [Q8NEJ9-1]
PIRiT08694.
RefSeqiNP_001036100.1. NM_001042635.1. [Q8NEJ9-1]
NP_056329.1. NM_015514.1. [Q8NEJ9-2]
UniGeneiHs.9043.

3D structure databases

ProteinModelPortaliQ8NEJ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117466. 20 interactions.
IntActiQ8NEJ9. 7 interactions.
MINTiMINT-3042536.
STRINGi9606.ENSP00000386134.

PTM databases

iPTMnetiQ8NEJ9.
PhosphoSiteiQ8NEJ9.

Polymorphism and mutation databases

BioMutaiNGDN.
DMDMi46395905.

Proteomic databases

EPDiQ8NEJ9.
MaxQBiQ8NEJ9.
PaxDbiQ8NEJ9.
PeptideAtlasiQ8NEJ9.
PRIDEiQ8NEJ9.
TopDownProteomicsiQ8NEJ9-1. [Q8NEJ9-1]

Protocols and materials databases

DNASUi25983.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397154; ENSP00000380340; ENSG00000129460. [Q8NEJ9-2]
ENST00000408901; ENSP00000386134; ENSG00000129460. [Q8NEJ9-1]
GeneIDi25983.
KEGGihsa:25983.
UCSCiuc001wjy.4. human. [Q8NEJ9-1]

Organism-specific databases

CTDi25983.
GeneCardsiNGDN.
HGNCiHGNC:20271. NGDN.
HPAiHPA000944.
MIMi610777. gene.
neXtProtiNX_Q8NEJ9.
PharmGKBiPA134957933.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3117. Eukaryota.
ENOG4111F0Z. LUCA.
GeneTreeiENSGT00500000044922.
HOGENOMiHOG000013129.
HOVERGENiHBG082025.
InParanoidiQ8NEJ9.
KOiK14765.
OMAiMDLTHLI.
OrthoDBiEOG091G0I9S.
PhylomeDBiQ8NEJ9.
TreeFamiTF313713.

Miscellaneous databases

GenomeRNAii25983.
PROiQ8NEJ9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129460.
CleanExiHS_NGDN.
ExpressionAtlasiQ8NEJ9. baseline and differential.
GenevisibleiQ8NEJ9. HS.

Family and domain databases

InterProiIPR007146. Sas10/Utp3/C1D.
[Graphical view]
PfamiPF04000. Sas10_Utp3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNGDN_HUMAN
AccessioniPrimary (citable) accession number: Q8NEJ9
Secondary accession number(s): A8K760, Q9Y400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.