Q8NEH6 (MNS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Meiosis-specific nuclear structural protein 1

Gene names

Name:

MNS1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the MNS1 family.

Ontologies

Keywords
Biological process	Meiosis
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	meiosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	intermediate filament Inferred from electronic annotation. Source: Compara nuclear envelope Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 495	495	Meiosis-specific nuclear structural protein 1		PRO_0000298921
Regions
	Coiled coil	28 – 410	383	Potential
	Compositional bias	63 – 373	311	Glu-rich
Amino acid modifications
	Modified residue	244	1	Phosphotyrosine By similarity
Natural variations
	Natural variant	10	1	C → Y. Corresponds to variant rs34807682 [ dbSNP | Ensembl ].		VAR_034737
	Natural variant	55	1	Q → P. Corresponds to variant rs1715919 [ dbSNP | Ensembl ].		VAR_034738
	Natural variant	216	1	I → T. Corresponds to variant rs35775595 [ dbSNP | Ensembl ].		VAR_034739
	Natural variant	244	1	Y → H. Ref.2 Corresponds to variant rs17852882 [ dbSNP | Ensembl ].		VAR_034740
	Natural variant	426	1	E → G. Ref.2 Corresponds to variant rs17853357 [ dbSNP | Ensembl ].		VAR_034741

Sequences

	Sequence		Length	Mass (Da)
	Q8NEH6 [UniParc]. Last modified August 21, 2007. Version 2. Checksum: 85EF33C9A659FBD1	FASTA	495	60,571
	10 20 30 40 50 60 MGSKRRNLSC SERHQKLVDE NYCKKLHVQA LKNVNSQIRN QMVQNENDNR VQRKQFLRLL 70 80 90 100 110 120 QNEQFELDME EAIQKAEENK RLKELQLKQE EKLAMELAKL KHESLKDEKM RQQVRENSIE 130 140 150 160 170 180 LRELEKKLKA AYMNKERAAQ IAEKDAIKYE QMKRDAEIAK TMMEEHKRII KEENAAEDKR 190 200 210 220 230 240 NKAKAQYYLD LEKQLEEQEK KKQEAYEQLL KEKLMIDEIV RKIYEEDQLE KQQKLEKMNA 250 260 270 280 290 300 MRRYIEEFQK EQALWRKKKR EEMEEENRKI IEFANMQQQR EEDRMAKVQE NEEKRLQLQN 310 320 330 340 350 360 ALTQKLEEML RQREDLEQVR QELYQEEQAE IYKSKLKEEA EKKLRKQKEM KQDFEEQMAL 370 380 390 400 410 420 KELVLQAAKE EEENFRKTML AKFAEDDRIE LMNAQKQRMK QLEHRRAVEK LIEERRQQFL 430 440 450 460 470 480 ADKQRELEEW QLQQRRQGFI NAIIEEERLK LLKEHATNLL GYLPKGVFKK EDDIDLLGEE 490 FRKVYQQRSE ICEEK

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-244 AND GLY-426. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK002084 mRNA. Translation: BAA92077.1. BC031046 mRNA. Translation: AAH31046.1. BC034991 mRNA. Translation: AAH34991.1.
IPI	IPI00549955.
RefSeq	NP_060835.1. NM_018365.2.
UniGene	Hs.444483.
3D structure databases
ProteinModelPortal	Q8NEH6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NEH6. 1 interaction.
MINT	MINT-1459670.
STRING	9606.ENSP00000260453.
PTM databases
PhosphoSite	Q8NEH6.
Polymorphism databases
DMDM	156632590.
Proteomic databases
PaxDb	Q8NEH6.
PRIDE	Q8NEH6.
Protocols and materials databases
DNASU	55329.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000260453; ENSP00000260453; ENSG00000138587.
GeneID	55329.
KEGG	hsa:55329.
UCSC	uc002adr.2. human.
Organism-specific databases
CTD	55329.
GeneCards	GC15M056720.
HGNC	HGNC:29636. MNS1.
HPA	HPA039975. HPA040382.
MIM	610766. gene.
neXtProt	NX_Q8NEH6.
PharmGKB	PA142671346.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG116635.
HOGENOM	HOG000006500.
HOVERGEN	HBG108140.
InParanoid	Q8NEH6.
OMA	AKTMMEE.
OrthoDB	EOG4QNMWG.
PhylomeDB	Q8NEH6.
Gene expression databases
ArrayExpress	Q8NEH6.
Bgee	Q8NEH6.
CleanEx	HS_MNS1.
Genevestigator	Q8NEH6.
Family and domain databases
InterPro	IPR026504. MNS1. [Graphical view]
PANTHER	PTHR19265. PTHR19265. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	55329.
NextBio	59614.
SOURCE	Search...

Entry information

Entry name

MNS1_HUMAN

Accession

Primary (citable) accession number: Q8NEH6
Secondary accession number(s): Q8IYT6, Q9NUP4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	April 3, 2013
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.