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Protein

Meiosis-specific nuclear structural protein 1

Gene

MNS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis.By similarity

GO - Molecular functioni

  • identical protein binding Source: MGI

GO - Biological processi

Keywordsi

Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Meiosis-specific nuclear structural protein 1
Gene namesi
Name:MNS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:29636. MNS1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55329.
OpenTargetsiENSG00000138587.
PharmGKBiPA142671346.

Polymorphism and mutation databases

BioMutaiMNS1.
DMDMi156632590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002989211 – 495Meiosis-specific nuclear structural protein 1Add BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NEH6.
PaxDbiQ8NEH6.
PeptideAtlasiQ8NEH6.
PRIDEiQ8NEH6.

PTM databases

iPTMnetiQ8NEH6.
PhosphoSitePlusiQ8NEH6.

Expressioni

Gene expression databases

BgeeiENSG00000138587.
CleanExiHS_MNS1.
GenevisibleiQ8NEH6. HS.

Organism-specific databases

HPAiHPA039975.
HPA040382.

Interactioni

GO - Molecular functioni

  • identical protein binding Source: MGI

Protein-protein interaction databases

BioGridi120610. 4 interactors.
IntActiQ8NEH6. 20 interactors.
MINTiMINT-1459670.
STRINGi9606.ENSP00000260453.

Structurei

3D structure databases

ProteinModelPortaliQ8NEH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 410Sequence analysisAdd BLAST383

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 373Glu-richAdd BLAST311

Sequence similaritiesi

Belongs to the MNS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFU7. Eukaryota.
ENOG410YXPQ. LUCA.
GeneTreeiENSGT00730000111210.
HOGENOMiHOG000006500.
HOVERGENiHBG108140.
InParanoidiQ8NEH6.
OMAiGCINEII.
OrthoDBiEOG091G0CNW.
PhylomeDBiQ8NEH6.
TreeFamiTF329219.

Family and domain databases

InterProiView protein in InterPro
IPR026504. MNS1.
PANTHERiPTHR19265:SF1. PTHR19265:SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NEH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKRRNLSC SERHQKLVDE NYCKKLHVQA LKNVNSQIRN QMVQNENDNR
60 70 80 90 100
VQRKQFLRLL QNEQFELDME EAIQKAEENK RLKELQLKQE EKLAMELAKL
110 120 130 140 150
KHESLKDEKM RQQVRENSIE LRELEKKLKA AYMNKERAAQ IAEKDAIKYE
160 170 180 190 200
QMKRDAEIAK TMMEEHKRII KEENAAEDKR NKAKAQYYLD LEKQLEEQEK
210 220 230 240 250
KKQEAYEQLL KEKLMIDEIV RKIYEEDQLE KQQKLEKMNA MRRYIEEFQK
260 270 280 290 300
EQALWRKKKR EEMEEENRKI IEFANMQQQR EEDRMAKVQE NEEKRLQLQN
310 320 330 340 350
ALTQKLEEML RQREDLEQVR QELYQEEQAE IYKSKLKEEA EKKLRKQKEM
360 370 380 390 400
KQDFEEQMAL KELVLQAAKE EEENFRKTML AKFAEDDRIE LMNAQKQRMK
410 420 430 440 450
QLEHRRAVEK LIEERRQQFL ADKQRELEEW QLQQRRQGFI NAIIEEERLK
460 470 480 490
LLKEHATNLL GYLPKGVFKK EDDIDLLGEE FRKVYQQRSE ICEEK
Length:495
Mass (Da):60,571
Last modified:August 21, 2007 - v2
Checksum:i85EF33C9A659FBD1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03473710C → Y. Corresponds to variant dbSNP:rs34807682Ensembl.1
Natural variantiVAR_03473855Q → P. Corresponds to variant dbSNP:rs1715919Ensembl.1
Natural variantiVAR_034739216I → T. Corresponds to variant dbSNP:rs35775595Ensembl.1
Natural variantiVAR_034740244Y → H1 PublicationCorresponds to variant dbSNP:rs17852882Ensembl.1
Natural variantiVAR_034741426E → G1 PublicationCorresponds to variant dbSNP:rs17853357Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002084 mRNA. Translation: BAA92077.1.
BC031046 mRNA. Translation: AAH31046.1.
BC034991 mRNA. Translation: AAH34991.1.
CCDSiCCDS10158.1.
RefSeqiNP_060835.1. NM_018365.2.
UniGeneiHs.444483.

Genome annotation databases

EnsembliENST00000260453; ENSP00000260453; ENSG00000138587.
GeneIDi55329.
KEGGihsa:55329.
UCSCiuc002adr.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002084 mRNA. Translation: BAA92077.1.
BC031046 mRNA. Translation: AAH31046.1.
BC034991 mRNA. Translation: AAH34991.1.
CCDSiCCDS10158.1.
RefSeqiNP_060835.1. NM_018365.2.
UniGeneiHs.444483.

3D structure databases

ProteinModelPortaliQ8NEH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120610. 4 interactors.
IntActiQ8NEH6. 20 interactors.
MINTiMINT-1459670.
STRINGi9606.ENSP00000260453.

PTM databases

iPTMnetiQ8NEH6.
PhosphoSitePlusiQ8NEH6.

Polymorphism and mutation databases

BioMutaiMNS1.
DMDMi156632590.

Proteomic databases

EPDiQ8NEH6.
PaxDbiQ8NEH6.
PeptideAtlasiQ8NEH6.
PRIDEiQ8NEH6.

Protocols and materials databases

DNASUi55329.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260453; ENSP00000260453; ENSG00000138587.
GeneIDi55329.
KEGGihsa:55329.
UCSCiuc002adr.2. human.

Organism-specific databases

CTDi55329.
DisGeNETi55329.
GeneCardsiMNS1.
HGNCiHGNC:29636. MNS1.
HPAiHPA039975.
HPA040382.
MIMi610766. gene.
neXtProtiNX_Q8NEH6.
OpenTargetsiENSG00000138587.
PharmGKBiPA142671346.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFU7. Eukaryota.
ENOG410YXPQ. LUCA.
GeneTreeiENSGT00730000111210.
HOGENOMiHOG000006500.
HOVERGENiHBG108140.
InParanoidiQ8NEH6.
OMAiGCINEII.
OrthoDBiEOG091G0CNW.
PhylomeDBiQ8NEH6.
TreeFamiTF329219.

Miscellaneous databases

GenomeRNAii55329.
PROiQ8NEH6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138587.
CleanExiHS_MNS1.
GenevisibleiQ8NEH6. HS.

Family and domain databases

InterProiView protein in InterPro
IPR026504. MNS1.
PANTHERiPTHR19265:SF1. PTHR19265:SF1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMNS1_HUMAN
AccessioniPrimary (citable) accession number: Q8NEH6
Secondary accession number(s): Q8IYT6, Q9NUP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: March 15, 2017
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.