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Q8NEG5

- ZSWM2_HUMAN

UniProt

Q8NEG5 - ZSWM2_HUMAN

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Protein

E3 ubiquitin-protein ligase ZSWIM2

Gene

ZSWIM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri54 – 8734SWIM-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri147 – 19852RING-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 27750ZZ-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 38845RING-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. ubiquitin-protein transferase activity Source: Ensembl
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  3. protein polyubiquitination Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase ZSWIM2 (EC:6.3.2.-)
Alternative name(s):
MEKK1-related protein X
Short name:
MEX
ZZ-type zinc finger-containing protein 2
Zinc finger SWIM domain-containing protein 2
Gene namesi
Name:ZSWIM2
Synonyms:ZZZ2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:30990. ZSWIM2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134900131.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 633633E3 ubiquitin-protein ligase ZSWIM2PRO_0000223097Add
BLAST

Post-translational modificationi

Polyubiquitinated. Polyubiquitination is followed by degradation via the proteasome (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ8NEG5.
PRIDEiQ8NEG5.

PTM databases

PhosphoSiteiQ8NEG5.

Expressioni

Gene expression databases

BgeeiQ8NEG5.
CleanExiHS_ZSWIM2.
ExpressionAtlasiQ8NEG5. baseline.
GenevestigatoriQ8NEG5.

Organism-specific databases

HPAiHPA036418.

Interactioni

Subunit structurei

Dimer. Interacts with UBE2D1.By similarity

Protein-protein interaction databases

BioGridi127342. 3 interactions.
IntActiQ8NEG5. 2 interactions.
MINTiMINT-1465934.

Structurei

Secondary structure

1
633
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi235 – 2373
Beta strandi246 – 2549
Beta strandi256 – 2583
Helixi259 – 2635
Helixi267 – 2693
Beta strandi272 – 2743
Beta strandi277 – 2793

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DIPNMR-A208-292[»]
ProteinModelPortaliQ8NEG5.
SMRiQ8NEG5. Positions 208-292, 343-389.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NEG5.

Family & Domainsi

Domaini

The SWIM-type zinc finger is reqiered for ubiquitination activity.By similarity

Sequence similaritiesi

Contains 2 RING-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SWIM-type zinc finger.PROSITE-ProRule annotation
Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri54 – 8734SWIM-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri147 – 19852RING-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 27750ZZ-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 38845RING-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG241067.
GeneTreeiENSGT00390000006826.
HOGENOMiHOG000065782.
HOVERGENiHBG060888.
InParanoidiQ8NEG5.
KOiK15716.
OMAiCRFGCGN.
OrthoDBiEOG769ZKK.
PhylomeDBiQ8NEG5.
TreeFamiTF333237.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR007527. Znf_SWIM.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF04434. SWIM. 1 hit.
PF13639. zf-RING_2. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 2 hits.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 2 hits.
PS50966. ZF_SWIM. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NEG5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRRGYKASE RRRHLSERLS WHQDQALSSS IYLLREMGPT GFLLREEEPE
60 70 80 90 100
YMDFRVFLGN PHVCNCSTFP KGGELCKHIC WVLLKKFKLP RNHESALQLG
110 120 130 140 150
LGEREISDLL RGIHRVQTPQ PGTNDENEHV EEDGYIKQKE IDSEDICSIC
160 170 180 190 200
QELLLEKKLP VTFCRFGCGN SIHIKCMKIL ANYQSTSNTS MLKCPLCRKE
210 220 230 240 250
FAPLKLILEE FKNSSKLVAA AEKERLDKHL GIPCNNCKQF PIEGKCYKCT
260 270 280 290 300
ECIEYHLCQE CFDSCCHLSH TFTFREKRNQ KWRSLEKRAD EVVKYIDTKN
310 320 330 340 350
EIEEKMSHFQ EKQGQVYTPK HIVRSLPLQL ITKNSKLLAP GYQCLLCLKA
360 370 380 390 400
FHLGQHTRLL PCTHKFHRKC IDNWLFHKCN SCPIDGQVIY NPLTWKNSAV
410 420 430 440 450
NGQAHQSVSN RDIIHLSKQK EPDLFIPGTG LVLKQNRLGI LPSIPQCNFD
460 470 480 490 500
ELNTPQSPKD AYENTTIDNL CSIKLDNSNS KKLTYDYKIS QHFPRYLQDL
510 520 530 540 550
PTVSFGKIPS QTLLPPIVHK NIVCPTAMES PCISGKFHTS LSRMTKGCKC
560 570 580 590 600
NNHNLKKTPA TKIREDNKRS TLLPEDFNLI VNWSTAKLSL SKRYSNCMGE
610 620 630
ITRKCSHLSR QPVSHSVNTK STELSLIIEG VQL
Length:633
Mass (Da):72,732
Last modified:November 30, 2010 - v2
Checksum:iFB5B74E5E7FA625C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881K → E in AAH31094. (PubMed:15489334)Curated
Sequence conflicti265 – 2651C → Y in AAH31094. (PubMed:15489334)Curated
Sequence conflicti302 – 3021I → T in AAH31094. (PubMed:15489334)Curated
Sequence conflicti385 – 3851D → G in AAH31094. (PubMed:15489334)Curated
Sequence conflicti486 – 4861D → E in AAH31094. (PubMed:15489334)Curated
Sequence conflicti537 – 5371F → Y in AAH31094. (PubMed:15489334)Curated
Sequence conflicti544 – 5441M → V in AAH31094. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK128006 mRNA. Translation: BAG54618.1.
AC018735 Genomic DNA. Translation: AAY14907.1.
AC103914 Genomic DNA. Translation: AAX82016.1.
CH471058 Genomic DNA. Translation: EAX10929.1.
BC031094 mRNA. Translation: AAH31094.1.
CCDSiCCDS33348.1.
RefSeqiNP_872327.2. NM_182521.2.
UniGeneiHs.375054.

Genome annotation databases

EnsembliENST00000295131; ENSP00000295131; ENSG00000163012.
GeneIDi151112.
KEGGihsa:151112.
UCSCiuc002upu.1. human.

Polymorphism databases

DMDMi313104068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK128006 mRNA. Translation: BAG54618.1 .
AC018735 Genomic DNA. Translation: AAY14907.1 .
AC103914 Genomic DNA. Translation: AAX82016.1 .
CH471058 Genomic DNA. Translation: EAX10929.1 .
BC031094 mRNA. Translation: AAH31094.1 .
CCDSi CCDS33348.1.
RefSeqi NP_872327.2. NM_182521.2.
UniGenei Hs.375054.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DIP NMR - A 208-292 [» ]
ProteinModelPortali Q8NEG5.
SMRi Q8NEG5. Positions 208-292, 343-389.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127342. 3 interactions.
IntActi Q8NEG5. 2 interactions.
MINTi MINT-1465934.

PTM databases

PhosphoSitei Q8NEG5.

Polymorphism databases

DMDMi 313104068.

Proteomic databases

PaxDbi Q8NEG5.
PRIDEi Q8NEG5.

Protocols and materials databases

DNASUi 151112.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295131 ; ENSP00000295131 ; ENSG00000163012 .
GeneIDi 151112.
KEGGi hsa:151112.
UCSCi uc002upu.1. human.

Organism-specific databases

CTDi 151112.
GeneCardsi GC02M187693.
HGNCi HGNC:30990. ZSWIM2.
HPAi HPA036418.
neXtProti NX_Q8NEG5.
PharmGKBi PA134900131.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG241067.
GeneTreei ENSGT00390000006826.
HOGENOMi HOG000065782.
HOVERGENi HBG060888.
InParanoidi Q8NEG5.
KOi K15716.
OMAi CRFGCGN.
OrthoDBi EOG769ZKK.
PhylomeDBi Q8NEG5.
TreeFami TF333237.

Miscellaneous databases

EvolutionaryTracei Q8NEG5.
GenomeRNAii 151112.
NextBioi 86587.
PROi Q8NEG5.

Gene expression databases

Bgeei Q8NEG5.
CleanExi HS_ZSWIM2.
ExpressionAtlasi Q8NEG5. baseline.
Genevestigatori Q8NEG5.

Family and domain databases

Gene3Di 3.30.40.10. 2 hits.
InterProi IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR007527. Znf_SWIM.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF04434. SWIM. 1 hit.
PF13639. zf-RING_2. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 2 hits.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view ]
PROSITEi PS50089. ZF_RING_2. 2 hits.
PS50966. ZF_SWIM. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "Solution structure of the ZZ domain of zinc finger SWIM domain containing protein 2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 208-292.

Entry informationi

Entry nameiZSWM2_HUMAN
AccessioniPrimary (citable) accession number: Q8NEG5
Secondary accession number(s): B3KXV6, Q53SI3, Q57ZY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3