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Q8NEG5 (ZSWM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase ZSWIM2

EC=6.3.2.-
Alternative name(s):
MEKK1-related protein X
Short name=MEX
ZZ-type zinc finger-containing protein 2
Zinc finger SWIM domain-containing protein 2
Gene names
Name:ZSWIM2
Synonyms:ZZZ2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length633 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes By similarity.

Subunit structure

Dimer By similarity. Interacts with UBE2D1 By similarity.

Domain

The SWIM-type zinc finger is reqiered for ubiquitination activity By similarity.

Post-translational modification

Polyubiquitinated. Polyubiquitination is followed by degradation via the proteasome By similarity.

Sequence similarities

Contains 2 RING-type zinc fingers.

Contains 1 SWIM-type zinc finger.

Contains 1 ZZ-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 633633E3 ubiquitin-protein ligase ZSWIM2
PRO_0000223097

Regions

Zinc finger54 – 8734SWIM-type
Zinc finger147 – 19852RING-type 1
Zinc finger228 – 27750ZZ-type
Zinc finger344 – 38845RING-type 2

Experimental info

Sequence conflict881K → E in AAH31094. Ref.4
Sequence conflict2651C → Y in AAH31094. Ref.4
Sequence conflict3021I → T in AAH31094. Ref.4
Sequence conflict3851D → G in AAH31094. Ref.4
Sequence conflict4861D → E in AAH31094. Ref.4
Sequence conflict5371F → Y in AAH31094. Ref.4
Sequence conflict5441M → V in AAH31094. Ref.4

Secondary structure

.............. 633
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8NEG5 [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: FB5B74E5E7FA625C

FASTA63372,732
        10         20         30         40         50         60 
MLRRGYKASE RRRHLSERLS WHQDQALSSS IYLLREMGPT GFLLREEEPE YMDFRVFLGN 

        70         80         90        100        110        120 
PHVCNCSTFP KGGELCKHIC WVLLKKFKLP RNHESALQLG LGEREISDLL RGIHRVQTPQ 

       130        140        150        160        170        180 
PGTNDENEHV EEDGYIKQKE IDSEDICSIC QELLLEKKLP VTFCRFGCGN SIHIKCMKIL 

       190        200        210        220        230        240 
ANYQSTSNTS MLKCPLCRKE FAPLKLILEE FKNSSKLVAA AEKERLDKHL GIPCNNCKQF 

       250        260        270        280        290        300 
PIEGKCYKCT ECIEYHLCQE CFDSCCHLSH TFTFREKRNQ KWRSLEKRAD EVVKYIDTKN 

       310        320        330        340        350        360 
EIEEKMSHFQ EKQGQVYTPK HIVRSLPLQL ITKNSKLLAP GYQCLLCLKA FHLGQHTRLL 

       370        380        390        400        410        420 
PCTHKFHRKC IDNWLFHKCN SCPIDGQVIY NPLTWKNSAV NGQAHQSVSN RDIIHLSKQK 

       430        440        450        460        470        480 
EPDLFIPGTG LVLKQNRLGI LPSIPQCNFD ELNTPQSPKD AYENTTIDNL CSIKLDNSNS 

       490        500        510        520        530        540 
KKLTYDYKIS QHFPRYLQDL PTVSFGKIPS QTLLPPIVHK NIVCPTAMES PCISGKFHTS 

       550        560        570        580        590        600 
LSRMTKGCKC NNHNLKKTPA TKIREDNKRS TLLPEDFNLI VNWSTAKLSL SKRYSNCMGE 

       610        620        630 
ITRKCSHLSR QPVSHSVNTK STELSLIIEG VQL 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[5]"Solution structure of the ZZ domain of zinc finger SWIM domain containing protein 2."
RIKEN structural genomics initiative (RSGI)
Submitted (FEB-2009) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 208-292.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK128006 mRNA. Translation: BAG54618.1.
AC018735 Genomic DNA. Translation: AAY14907.1.
AC103914 Genomic DNA. Translation: AAX82016.1.
CH471058 Genomic DNA. Translation: EAX10929.1.
BC031094 mRNA. Translation: AAH31094.1.
RefSeqNP_872327.2. NM_182521.2.
UniGeneHs.375054.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DIPNMR-A208-292[»]
ProteinModelPortalQ8NEG5.
SMRQ8NEG5. Positions 141-197, 208-292, 341-389.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127342. 3 interactions.
IntActQ8NEG5. 2 interactions.
MINTMINT-1465934.

PTM databases

PhosphoSiteQ8NEG5.

Polymorphism databases

DMDM313104068.

Proteomic databases

PaxDbQ8NEG5.
PRIDEQ8NEG5.

Protocols and materials databases

DNASU151112.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295131; ENSP00000295131; ENSG00000163012.
GeneID151112.
KEGGhsa:151112.
UCSCuc002upu.1. human.

Organism-specific databases

CTD151112.
GeneCardsGC02M187693.
HGNCHGNC:30990. ZSWIM2.
HPAHPA036418.
neXtProtNX_Q8NEG5.
PharmGKBPA134900131.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG241067.
HOGENOMHOG000065782.
HOVERGENHBG060888.
InParanoidQ8NEG5.
KOK15716.
OMACRFGCGN.
OrthoDBEOG769ZKK.
PhylomeDBQ8NEG5.
TreeFamTF333237.

Gene expression databases

BgeeQ8NEG5.
CleanExHS_ZSWIM2.
GenevestigatorQ8NEG5.

Family and domain databases

Gene3D3.30.40.10. 2 hits.
InterProIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR007527. Znf_SWIM.
IPR000433. Znf_ZZ.
[Graphical view]
PfamPF04434. SWIM. 1 hit.
PF13639. zf-RING_2. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTSM00184. RING. 2 hits.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
PROSITEPS50089. ZF_RING_2. 2 hits.
PS50966. ZF_SWIM. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ8NEG5.
GenomeRNAi151112.
NextBio86587.
PROQ8NEG5.

Entry information

Entry nameZSWM2_HUMAN
AccessionPrimary (citable) accession number: Q8NEG5
Secondary accession number(s): B3KXV6, Q53SI3, Q57ZY3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM