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Q8NEG5

- ZSWM2_HUMAN

UniProt

Q8NEG5 - ZSWM2_HUMAN

Protein

E3 ubiquitin-protein ligase ZSWIM2

Gene

ZSWIM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri54 – 8734SWIM-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri147 – 19852RING-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 27750ZZ-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri344 – 38845RING-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. ubiquitin-protein transferase activity Source: Ensembl
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    3. protein polyubiquitination Source: Ensembl

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Apoptosis, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase ZSWIM2 (EC:6.3.2.-)
    Alternative name(s):
    MEKK1-related protein X
    Short name:
    MEX
    ZZ-type zinc finger-containing protein 2
    Zinc finger SWIM domain-containing protein 2
    Gene namesi
    Name:ZSWIM2
    Synonyms:ZZZ2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:30990. ZSWIM2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134900131.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 633633E3 ubiquitin-protein ligase ZSWIM2PRO_0000223097Add
    BLAST

    Post-translational modificationi

    Polyubiquitinated. Polyubiquitination is followed by degradation via the proteasome By similarity.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PaxDbiQ8NEG5.
    PRIDEiQ8NEG5.

    PTM databases

    PhosphoSiteiQ8NEG5.

    Expressioni

    Gene expression databases

    BgeeiQ8NEG5.
    CleanExiHS_ZSWIM2.
    GenevestigatoriQ8NEG5.

    Organism-specific databases

    HPAiHPA036418.

    Interactioni

    Subunit structurei

    Dimer. Interacts with UBE2D1.By similarity

    Protein-protein interaction databases

    BioGridi127342. 3 interactions.
    IntActiQ8NEG5. 2 interactions.
    MINTiMINT-1465934.

    Structurei

    Secondary structure

    1
    633
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi235 – 2373
    Beta strandi246 – 2549
    Beta strandi256 – 2583
    Helixi259 – 2635
    Helixi267 – 2693
    Beta strandi272 – 2743
    Beta strandi277 – 2793

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DIPNMR-A208-292[»]
    ProteinModelPortaliQ8NEG5.
    SMRiQ8NEG5. Positions 146-202, 208-292, 342-389.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8NEG5.

    Family & Domainsi

    Domaini

    The SWIM-type zinc finger is reqiered for ubiquitination activity.By similarity

    Sequence similaritiesi

    Contains 2 RING-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SWIM-type zinc finger.PROSITE-ProRule annotation
    Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri54 – 8734SWIM-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri147 – 19852RING-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 27750ZZ-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri344 – 38845RING-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG241067.
    HOGENOMiHOG000065782.
    HOVERGENiHBG060888.
    InParanoidiQ8NEG5.
    KOiK15716.
    OMAiCRFGCGN.
    OrthoDBiEOG769ZKK.
    PhylomeDBiQ8NEG5.
    TreeFamiTF333237.

    Family and domain databases

    Gene3Di3.30.40.10. 2 hits.
    InterProiIPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR007527. Znf_SWIM.
    IPR000433. Znf_ZZ.
    [Graphical view]
    PfamiPF04434. SWIM. 1 hit.
    PF13639. zf-RING_2. 1 hit.
    PF00569. ZZ. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 2 hits.
    SM00291. ZnF_ZZ. 1 hit.
    [Graphical view]
    PROSITEiPS50089. ZF_RING_2. 2 hits.
    PS50966. ZF_SWIM. 1 hit.
    PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NEG5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRRGYKASE RRRHLSERLS WHQDQALSSS IYLLREMGPT GFLLREEEPE    50
    YMDFRVFLGN PHVCNCSTFP KGGELCKHIC WVLLKKFKLP RNHESALQLG 100
    LGEREISDLL RGIHRVQTPQ PGTNDENEHV EEDGYIKQKE IDSEDICSIC 150
    QELLLEKKLP VTFCRFGCGN SIHIKCMKIL ANYQSTSNTS MLKCPLCRKE 200
    FAPLKLILEE FKNSSKLVAA AEKERLDKHL GIPCNNCKQF PIEGKCYKCT 250
    ECIEYHLCQE CFDSCCHLSH TFTFREKRNQ KWRSLEKRAD EVVKYIDTKN 300
    EIEEKMSHFQ EKQGQVYTPK HIVRSLPLQL ITKNSKLLAP GYQCLLCLKA 350
    FHLGQHTRLL PCTHKFHRKC IDNWLFHKCN SCPIDGQVIY NPLTWKNSAV 400
    NGQAHQSVSN RDIIHLSKQK EPDLFIPGTG LVLKQNRLGI LPSIPQCNFD 450
    ELNTPQSPKD AYENTTIDNL CSIKLDNSNS KKLTYDYKIS QHFPRYLQDL 500
    PTVSFGKIPS QTLLPPIVHK NIVCPTAMES PCISGKFHTS LSRMTKGCKC 550
    NNHNLKKTPA TKIREDNKRS TLLPEDFNLI VNWSTAKLSL SKRYSNCMGE 600
    ITRKCSHLSR QPVSHSVNTK STELSLIIEG VQL 633
    Length:633
    Mass (Da):72,732
    Last modified:November 30, 2010 - v2
    Checksum:iFB5B74E5E7FA625C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti88 – 881K → E in AAH31094. (PubMed:15489334)Curated
    Sequence conflicti265 – 2651C → Y in AAH31094. (PubMed:15489334)Curated
    Sequence conflicti302 – 3021I → T in AAH31094. (PubMed:15489334)Curated
    Sequence conflicti385 – 3851D → G in AAH31094. (PubMed:15489334)Curated
    Sequence conflicti486 – 4861D → E in AAH31094. (PubMed:15489334)Curated
    Sequence conflicti537 – 5371F → Y in AAH31094. (PubMed:15489334)Curated
    Sequence conflicti544 – 5441M → V in AAH31094. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK128006 mRNA. Translation: BAG54618.1.
    AC018735 Genomic DNA. Translation: AAY14907.1.
    AC103914 Genomic DNA. Translation: AAX82016.1.
    CH471058 Genomic DNA. Translation: EAX10929.1.
    BC031094 mRNA. Translation: AAH31094.1.
    CCDSiCCDS33348.1.
    RefSeqiNP_872327.2. NM_182521.2.
    UniGeneiHs.375054.

    Genome annotation databases

    EnsembliENST00000295131; ENSP00000295131; ENSG00000163012.
    GeneIDi151112.
    KEGGihsa:151112.
    UCSCiuc002upu.1. human.

    Polymorphism databases

    DMDMi313104068.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK128006 mRNA. Translation: BAG54618.1 .
    AC018735 Genomic DNA. Translation: AAY14907.1 .
    AC103914 Genomic DNA. Translation: AAX82016.1 .
    CH471058 Genomic DNA. Translation: EAX10929.1 .
    BC031094 mRNA. Translation: AAH31094.1 .
    CCDSi CCDS33348.1.
    RefSeqi NP_872327.2. NM_182521.2.
    UniGenei Hs.375054.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DIP NMR - A 208-292 [» ]
    ProteinModelPortali Q8NEG5.
    SMRi Q8NEG5. Positions 146-202, 208-292, 342-389.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127342. 3 interactions.
    IntActi Q8NEG5. 2 interactions.
    MINTi MINT-1465934.

    PTM databases

    PhosphoSitei Q8NEG5.

    Polymorphism databases

    DMDMi 313104068.

    Proteomic databases

    PaxDbi Q8NEG5.
    PRIDEi Q8NEG5.

    Protocols and materials databases

    DNASUi 151112.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295131 ; ENSP00000295131 ; ENSG00000163012 .
    GeneIDi 151112.
    KEGGi hsa:151112.
    UCSCi uc002upu.1. human.

    Organism-specific databases

    CTDi 151112.
    GeneCardsi GC02M187693.
    HGNCi HGNC:30990. ZSWIM2.
    HPAi HPA036418.
    neXtProti NX_Q8NEG5.
    PharmGKBi PA134900131.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241067.
    HOGENOMi HOG000065782.
    HOVERGENi HBG060888.
    InParanoidi Q8NEG5.
    KOi K15716.
    OMAi CRFGCGN.
    OrthoDBi EOG769ZKK.
    PhylomeDBi Q8NEG5.
    TreeFami TF333237.

    Miscellaneous databases

    EvolutionaryTracei Q8NEG5.
    GenomeRNAii 151112.
    NextBioi 86587.
    PROi Q8NEG5.

    Gene expression databases

    Bgeei Q8NEG5.
    CleanExi HS_ZSWIM2.
    Genevestigatori Q8NEG5.

    Family and domain databases

    Gene3Di 3.30.40.10. 2 hits.
    InterProi IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR007527. Znf_SWIM.
    IPR000433. Znf_ZZ.
    [Graphical view ]
    Pfami PF04434. SWIM. 1 hit.
    PF13639. zf-RING_2. 1 hit.
    PF00569. ZZ. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 2 hits.
    SM00291. ZnF_ZZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50089. ZF_RING_2. 2 hits.
    PS50966. ZF_SWIM. 1 hit.
    PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. "Solution structure of the ZZ domain of zinc finger SWIM domain containing protein 2."
      RIKEN structural genomics initiative (RSGI)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 208-292.

    Entry informationi

    Entry nameiZSWM2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NEG5
    Secondary accession number(s): B3KXV6, Q53SI3, Q57ZY3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3