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Protein

E3 ubiquitin-protein ligase ZSWIM2

Gene

ZSWIM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri54 – 87SWIM-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri147 – 198RING-type 1PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri228 – 277ZZ-typePROSITE-ProRule annotationAdd BLAST50
Zinc fingeri344 – 388RING-type 2PROSITE-ProRule annotationAdd BLAST45

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163012-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase ZSWIM2 (EC:6.3.2.-)
Alternative name(s):
MEKK1-related protein X
Short name:
MEX
ZZ-type zinc finger-containing protein 2
Zinc finger SWIM domain-containing protein 2
Gene namesi
Name:ZSWIM2
Synonyms:ZZZ2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:30990. ZSWIM2.

Pathology & Biotechi

Organism-specific databases

DisGeNETi151112.
OpenTargetsiENSG00000163012.
PharmGKBiPA134900131.

Polymorphism and mutation databases

BioMutaiZSWIM2.
DMDMi313104068.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002230971 – 633E3 ubiquitin-protein ligase ZSWIM2Add BLAST633

Post-translational modificationi

Polyubiquitinated. Polyubiquitination is followed by degradation via the proteasome (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ8NEG5.
PeptideAtlasiQ8NEG5.
PRIDEiQ8NEG5.

PTM databases

iPTMnetiQ8NEG5.
PhosphoSitePlusiQ8NEG5.

Expressioni

Gene expression databases

BgeeiENSG00000163012.
CleanExiHS_ZSWIM2.
ExpressionAtlasiQ8NEG5. baseline and differential.
GenevisibleiQ8NEG5. HS.

Organism-specific databases

HPAiHPA036418.
HPA036419.

Interactioni

Subunit structurei

Dimer. Interacts with UBE2D1.By similarity

Protein-protein interaction databases

BioGridi127342. 7 interactors.
IntActiQ8NEG5. 2 interactors.
MINTiMINT-1465934.
STRINGi9606.ENSP00000295131.

Structurei

Secondary structure

1633
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi235 – 237Combined sources3
Beta strandi246 – 254Combined sources9
Beta strandi256 – 258Combined sources3
Helixi259 – 263Combined sources5
Helixi267 – 269Combined sources3
Beta strandi272 – 274Combined sources3
Beta strandi277 – 279Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DIPNMR-A208-292[»]
ProteinModelPortaliQ8NEG5.
SMRiQ8NEG5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NEG5.

Family & Domainsi

Domaini

The SWIM-type zinc finger is reqiered for ubiquitination activity.By similarity

Sequence similaritiesi

Contains 2 RING-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SWIM-type zinc finger.PROSITE-ProRule annotation
Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri54 – 87SWIM-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri147 – 198RING-type 1PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri228 – 277ZZ-typePROSITE-ProRule annotationAdd BLAST50
Zinc fingeri344 – 388RING-type 2PROSITE-ProRule annotationAdd BLAST45

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00390000006826.
HOGENOMiHOG000065782.
HOVERGENiHBG060888.
InParanoidiQ8NEG5.
KOiK15716.
OMAiCRFGCGN.
OrthoDBiEOG091G0F9U.
PhylomeDBiQ8NEG5.
TreeFamiTF333237.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR007527. Znf_SWIM.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF04434. SWIM. 1 hit.
PF13639. zf-RING_2. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 2 hits.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 2 hits.
PS50966. ZF_SWIM. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NEG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRGYKASE RRRHLSERLS WHQDQALSSS IYLLREMGPT GFLLREEEPE
60 70 80 90 100
YMDFRVFLGN PHVCNCSTFP KGGELCKHIC WVLLKKFKLP RNHESALQLG
110 120 130 140 150
LGEREISDLL RGIHRVQTPQ PGTNDENEHV EEDGYIKQKE IDSEDICSIC
160 170 180 190 200
QELLLEKKLP VTFCRFGCGN SIHIKCMKIL ANYQSTSNTS MLKCPLCRKE
210 220 230 240 250
FAPLKLILEE FKNSSKLVAA AEKERLDKHL GIPCNNCKQF PIEGKCYKCT
260 270 280 290 300
ECIEYHLCQE CFDSCCHLSH TFTFREKRNQ KWRSLEKRAD EVVKYIDTKN
310 320 330 340 350
EIEEKMSHFQ EKQGQVYTPK HIVRSLPLQL ITKNSKLLAP GYQCLLCLKA
360 370 380 390 400
FHLGQHTRLL PCTHKFHRKC IDNWLFHKCN SCPIDGQVIY NPLTWKNSAV
410 420 430 440 450
NGQAHQSVSN RDIIHLSKQK EPDLFIPGTG LVLKQNRLGI LPSIPQCNFD
460 470 480 490 500
ELNTPQSPKD AYENTTIDNL CSIKLDNSNS KKLTYDYKIS QHFPRYLQDL
510 520 530 540 550
PTVSFGKIPS QTLLPPIVHK NIVCPTAMES PCISGKFHTS LSRMTKGCKC
560 570 580 590 600
NNHNLKKTPA TKIREDNKRS TLLPEDFNLI VNWSTAKLSL SKRYSNCMGE
610 620 630
ITRKCSHLSR QPVSHSVNTK STELSLIIEG VQL
Length:633
Mass (Da):72,732
Last modified:November 30, 2010 - v2
Checksum:iFB5B74E5E7FA625C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88K → E in AAH31094 (PubMed:15489334).Curated1
Sequence conflicti265C → Y in AAH31094 (PubMed:15489334).Curated1
Sequence conflicti302I → T in AAH31094 (PubMed:15489334).Curated1
Sequence conflicti385D → G in AAH31094 (PubMed:15489334).Curated1
Sequence conflicti486D → E in AAH31094 (PubMed:15489334).Curated1
Sequence conflicti537F → Y in AAH31094 (PubMed:15489334).Curated1
Sequence conflicti544M → V in AAH31094 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128006 mRNA. Translation: BAG54618.1.
AC018735 Genomic DNA. Translation: AAY14907.1.
AC103914 Genomic DNA. Translation: AAX82016.1.
CH471058 Genomic DNA. Translation: EAX10929.1.
BC031094 mRNA. Translation: AAH31094.1.
CCDSiCCDS33348.1.
RefSeqiNP_872327.2. NM_182521.2.
UniGeneiHs.375054.

Genome annotation databases

EnsembliENST00000295131; ENSP00000295131; ENSG00000163012.
GeneIDi151112.
KEGGihsa:151112.
UCSCiuc002upu.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128006 mRNA. Translation: BAG54618.1.
AC018735 Genomic DNA. Translation: AAY14907.1.
AC103914 Genomic DNA. Translation: AAX82016.1.
CH471058 Genomic DNA. Translation: EAX10929.1.
BC031094 mRNA. Translation: AAH31094.1.
CCDSiCCDS33348.1.
RefSeqiNP_872327.2. NM_182521.2.
UniGeneiHs.375054.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DIPNMR-A208-292[»]
ProteinModelPortaliQ8NEG5.
SMRiQ8NEG5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127342. 7 interactors.
IntActiQ8NEG5. 2 interactors.
MINTiMINT-1465934.
STRINGi9606.ENSP00000295131.

PTM databases

iPTMnetiQ8NEG5.
PhosphoSitePlusiQ8NEG5.

Polymorphism and mutation databases

BioMutaiZSWIM2.
DMDMi313104068.

Proteomic databases

PaxDbiQ8NEG5.
PeptideAtlasiQ8NEG5.
PRIDEiQ8NEG5.

Protocols and materials databases

DNASUi151112.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295131; ENSP00000295131; ENSG00000163012.
GeneIDi151112.
KEGGihsa:151112.
UCSCiuc002upu.2. human.

Organism-specific databases

CTDi151112.
DisGeNETi151112.
GeneCardsiZSWIM2.
HGNCiHGNC:30990. ZSWIM2.
HPAiHPA036418.
HPA036419.
neXtProtiNX_Q8NEG5.
OpenTargetsiENSG00000163012.
PharmGKBiPA134900131.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00390000006826.
HOGENOMiHOG000065782.
HOVERGENiHBG060888.
InParanoidiQ8NEG5.
KOiK15716.
OMAiCRFGCGN.
OrthoDBiEOG091G0F9U.
PhylomeDBiQ8NEG5.
TreeFamiTF333237.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163012-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8NEG5.
GenomeRNAii151112.
PROiQ8NEG5.

Gene expression databases

BgeeiENSG00000163012.
CleanExiHS_ZSWIM2.
ExpressionAtlasiQ8NEG5. baseline and differential.
GenevisibleiQ8NEG5. HS.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR007527. Znf_SWIM.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF04434. SWIM. 1 hit.
PF13639. zf-RING_2. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 2 hits.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 2 hits.
PS50966. ZF_SWIM. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZSWM2_HUMAN
AccessioniPrimary (citable) accession number: Q8NEG5
Secondary accession number(s): B3KXV6, Q53SI3, Q57ZY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.