Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein FAM71C

Gene

FAM71C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM71C
Gene namesi
Name:FAM71C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:28594. FAM71C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485460.

Polymorphism and mutation databases

BioMutaiFAM71C.
DMDMi74730248.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Protein FAM71CPRO_0000266044Add
BLAST

Proteomic databases

PaxDbiQ8NEG0.
PRIDEiQ8NEG0.

Expressioni

Gene expression databases

BgeeiQ8NEG0.
CleanExiHS_FAM71C.
GenevisibleiQ8NEG0. HS.

Organism-specific databases

HPAiHPA042569.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BANPQ8N9N53EBI-752049,EBI-744695
FHL3Q136433EBI-752049,EBI-741101
KRT31Q153233EBI-752049,EBI-948001
KRT40Q6A1623EBI-752049,EBI-10171697
NOTCH2NLQ7Z3S93EBI-752049,EBI-945833
RAB2AP610194EBI-752049,EBI-752037
RAB2BQ8WUD15EBI-752049,EBI-5542466

Protein-protein interaction databases

BioGridi128210. 8 interactions.
IntActiQ8NEG0. 9 interactions.
MINTiMINT-1457493.

Structurei

3D structure databases

ProteinModelPortaliQ8NEG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM71 family.Curated

Phylogenomic databases

eggNOGiENOG410J9TF. Eukaryota.
ENOG410YQV3. LUCA.
GeneTreeiENSGT00530000063078.
HOGENOMiHOG000112478.
HOVERGENiHBG081511.
InParanoidiQ8NEG0.
OMAiLYKGEYA.
OrthoDBiEOG71ZP2J.
PhylomeDBiQ8NEG0.
TreeFamiTF336050.

Family and domain databases

InterProiIPR022168. DUF3699.
[Graphical view]
PfamiPF12480. DUF3699. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NEG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDCCMLPYY TAQSSPAMGM FNTSMGKLQR QLYKGEYTIF RYAPMFESDF
60 70 80 90 100
IQISKRGEVI DVHNRARMVT MGIVRTSPCL TLPDVMLLAR PAAVCDNARC
110 120 130 140 150
GPATQKRESP PAEILELTRL LPLMFVKITI HNSVKKQLHL KLATGRSFYL
160 170 180 190 200
QLCPPSDASE DLFVHWENLV YILRPPVEAY SDTRAILAGN TLDSSVLEEV
210 220 230 240
QRSPVGYAMK FCEEKEQFRI SRLHMNAEMF GSTYCDYTIE I
Length:241
Mass (Da):27,472
Last modified:October 1, 2002 - v1
Checksum:iAF69C82913202B09
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti220 – 2201I → V in BAG35633 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301R → G.
Corresponds to variant rs11109968 [ dbSNP | Ensembl ].
VAR_029638
Natural varianti71 – 711M → V.
Corresponds to variant rs11109969 [ dbSNP | Ensembl ].
VAR_029639

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312767 mRNA. Translation: BAG35633.1.
BC031221 mRNA. Translation: AAH31221.1.
CCDSiCCDS9072.1.
RefSeqiNP_699195.1. NM_153364.3.
UniGeneiHs.591011.

Genome annotation databases

EnsembliENST00000324341; ENSP00000315247; ENSG00000180219.
GeneIDi196472.
KEGGihsa:196472.
UCSCiuc001tgn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312767 mRNA. Translation: BAG35633.1.
BC031221 mRNA. Translation: AAH31221.1.
CCDSiCCDS9072.1.
RefSeqiNP_699195.1. NM_153364.3.
UniGeneiHs.591011.

3D structure databases

ProteinModelPortaliQ8NEG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128210. 8 interactions.
IntActiQ8NEG0. 9 interactions.
MINTiMINT-1457493.

Polymorphism and mutation databases

BioMutaiFAM71C.
DMDMi74730248.

Proteomic databases

PaxDbiQ8NEG0.
PRIDEiQ8NEG0.

Protocols and materials databases

DNASUi196472.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324341; ENSP00000315247; ENSG00000180219.
GeneIDi196472.
KEGGihsa:196472.
UCSCiuc001tgn.4. human.

Organism-specific databases

CTDi196472.
GeneCardsiFAM71C.
HGNCiHGNC:28594. FAM71C.
HPAiHPA042569.
neXtProtiNX_Q8NEG0.
PharmGKBiPA143485460.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9TF. Eukaryota.
ENOG410YQV3. LUCA.
GeneTreeiENSGT00530000063078.
HOGENOMiHOG000112478.
HOVERGENiHBG081511.
InParanoidiQ8NEG0.
OMAiLYKGEYA.
OrthoDBiEOG71ZP2J.
PhylomeDBiQ8NEG0.
TreeFamiTF336050.

Miscellaneous databases

GenomeRNAii196472.
NextBioi35467627.
PROiQ8NEG0.

Gene expression databases

BgeeiQ8NEG0.
CleanExiHS_FAM71C.
GenevisibleiQ8NEG0. HS.

Family and domain databases

InterProiIPR022168. DUF3699.
[Graphical view]
PfamiPF12480. DUF3699. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiFA71C_HUMAN
AccessioniPrimary (citable) accession number: Q8NEG0
Secondary accession number(s): B2R6Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.