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Protein

Serum response factor-binding protein 1

Gene

SRFBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity).By similarity

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Serum response factor-binding protein 1
Alternative name(s):
SRF-dependent transcription regulation-associated protein
p49/STRAP
Gene namesi
Name:SRFBP1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000151304.5.
HGNCiHGNC:26333. SRFBP1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151304.
PharmGKBiPA142670870.

Polymorphism and mutation databases

BioMutaiSRFBP1.
DMDMi74751249.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00003200062 – 429Serum response factor-binding protein 1Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Cross-linki190Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei203PhosphoserineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei264PhosphoserineCombined sources1
Modified residuei279PhosphoserineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Cross-linki316Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei349PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1
Modified residuei367PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8NEF9.
MaxQBiQ8NEF9.
PaxDbiQ8NEF9.
PeptideAtlasiQ8NEF9.
PRIDEiQ8NEF9.
TopDownProteomicsiQ8NEF9.

PTM databases

iPTMnetiQ8NEF9.
PhosphoSitePlusiQ8NEF9.

Expressioni

Tissue specificityi

Abundantly expressed in heart and skeletal muscle, and at much lower levels in brain and lung.1 Publication

Developmental stagei

Up-regulated in adult heart (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000151304.
CleanExiHS_SRFBP1.
GenevisibleiQ8NEF9. HS.

Organism-specific databases

HPAiHPA042737.
HPA058150.

Interactioni

Subunit structurei

Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi127495. 8 interactors.
IntActiQ8NEF9. 6 interactors.
MINTiMINT-4932778.
STRINGi9606.ENSP00000341324.

Structurei

3D structure databases

ProteinModelPortaliQ8NEF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili42 – 67Sequence analysisAdd BLAST26
Coiled coili108 – 146Sequence analysisAdd BLAST39

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEZ8. Eukaryota.
ENOG4111UG3. LUCA.
GeneTreeiENSGT00390000006478.
HOGENOMiHOG000154413.
HOVERGENiHBG056694.
InParanoidiQ8NEF9.
OMAiFKEARQN.
OrthoDBiEOG091G0APQ.
PhylomeDBiQ8NEF9.
TreeFamiTF328596.

Family and domain databases

InterProiView protein in InterPro
IPR015158. Bud22/SRFB1.
PfamiView protein in Pfam
PF09073. BUD22. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NEF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQPGTLNLN NEVVKMRKEV KRIRVLVIRK LVRSVGRLKS KKGTEDALLK
60 70 80 90 100
NQRRAQRLLE EIHAMKELKP DIVTKSALGD DINFEKIFKK PDSTATERAI
110 120 130 140 150
ARLAVHPLLK KKIDVLKAAV QAFKEARQNV AEVESSKNAS EDNHSENTLY
160 170 180 190 200
SNDNGSNLQR EATVISEQKV KETKILAKKP IHNSKEKIAK MEHGPKAVTI
210 220 230 240 250
ANSPSKPSEK DSVVSLESQK TPADPKLKTL SQTKKNKGSD SSLSGNSDGG
260 270 280 290 300
EEFCEEEKEY FDDSTEERFY KQSSMSEDSD SGDDFFIGKV RRTRKKESSC
310 320 330 340 350
HSSVKEQKPL EKVFLKEDTG ETHGDTRNDK IKPSTETRKL ESVFFHSLSG
360 370 380 390 400
SKSSRRNFKE QAPKTRSLDF PQNEPQIKNQ FNKKLSGRLE NTKQQLQLPL
410 420
HPSWEASRRR KEQQSNIAVF QGKKITFDD
Length:429
Mass (Da):48,634
Last modified:October 1, 2002 - v1
Checksum:i6046C3E73C87BCF0
GO

Sequence cautioni

The sequence BAB71631 differs from that shown. Reason: Frameshift at position 425.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti345F → S in BAB71631 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY611630 mRNA. Translation: AAU25829.2.
AK058015 mRNA. Translation: BAB71631.1. Frameshift.
CH471086 Genomic DNA. Translation: EAW48900.1.
BC017102 mRNA. Translation: AAH17102.1.
BC031222 mRNA. Translation: AAH31222.1.
CCDSiCCDS43354.1.
RefSeqiNP_689759.2. NM_152546.2.
UniGeneiHs.107622.

Genome annotation databases

EnsembliENST00000339397; ENSP00000341324; ENSG00000151304.
GeneIDi153443.
KEGGihsa:153443.
UCSCiuc003kst.2. human.

Similar proteinsi

Entry informationi

Entry nameiSRFB1_HUMAN
AccessioniPrimary (citable) accession number: Q8NEF9
Secondary accession number(s): Q5QFI2, Q96AH4, Q96DK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot