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Protein

Tetratricopeptide repeat protein 16

Gene

TTC16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 16
Short name:
TPR repeat protein 16
Gene namesi
Name:TTC16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:26536. TTC16.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871808.

Polymorphism and mutation databases

BioMutaiTTC16.
DMDMi90110783.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 873873Tetratricopeptide repeat protein 16PRO_0000106403Add
BLAST

Proteomic databases

EPDiQ8NEE8.
PaxDbiQ8NEE8.
PeptideAtlasiQ8NEE8.
PRIDEiQ8NEE8.

PTM databases

iPTMnetiQ8NEE8.
PhosphoSiteiQ8NEE8.

Expressioni

Gene expression databases

BgeeiENSG00000167094.
CleanExiHS_TTC16.
GenevisibleiQ8NEE8. HS.

Organism-specific databases

HPAiHPA023260.
HPA028714.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362386.

Structurei

3D structure databases

ProteinModelPortaliQ8NEE8.
SMRiQ8NEE8. Positions 57-122, 280-316, 332-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati61 – 9434TPR 1Add
BLAST
Repeati96 – 12833TPR 2Add
BLAST
Repeati136 – 16934TPR 3Add
BLAST
Repeati251 – 28434TPR 4Add
BLAST
Repeati285 – 31834TPR 5Add
BLAST
Repeati331 – 36434TPR 6Add
BLAST
Repeati365 – 39834TPR 7Add
BLAST
Repeati406 – 43934TPR 8Add
BLAST

Sequence similaritiesi

Contains 8 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000004550.
HOGENOMiHOG000294213.
HOVERGENiHBG056302.
InParanoidiQ8NEE8.
OMAiCQEYRST.
OrthoDBiEOG091G03X3.
PhylomeDBiQ8NEE8.
TreeFamiTF350096.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 9 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 8 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NEE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDSDEDALK VDQGPSRDIP KPWVIPAPKG ILQHIFGTSH VFQSICDVKP
60 70 80 90 100
KVTGLTVPLK VREYYSRGQQ CLEQADWETA VLLFSRALHL DPQLVDFYAL
110 120 130 140 150
RAEAYLQLCD FSSAAQNLRR AYSLQQDNCK HLERLTFVLY LQGQCLFEQC
160 170 180 190 200
AFLDALNVFS HAAELQPEKP CFRYRCMACL LALKQHQACL TLITNELKQD
210 220 230 240 250
TTNADVYIFR ARLYNFLQKP HLCYRDLHSA LLLNPKHPQA RMLLQKMVAQ
260 270 280 290 300
AQQARQDAGI LAVQGKLQHA LQRINRAIEN NPLDPSLFLF RGTMYRRLQE
310 320 330 340 350
FDGAVEDFLK VLDMVTEDQE DMVRQAQRQL LLTYNDFAVH CYRQGAYQEG
360 370 380 390 400
VLLLNKALRD EQQEKGLYIN RGDCFFQLGN LAFAEADYQQ ALALSPQDEG
410 420 430 440 450
ANTRMGLLQE KMGFCEQRRK QFQKAENHFS TAIRHNPQKA QYYLYRAKSR
460 470 480 490 500
QLLQNIFGAR QDVATVLLLN PKQPKLSLLM TNLFPGMSVE EVLSTQIAHL
510 520 530 540 550
ARLQLEQMVE GSLQAGSPQG IVGMLKRHEL ERQKALALQH SWKQGEPLIA
560 570 580 590 600
TSEELKATPE IPQVKPGSSE GEAEAPEEEE EKEKEKKEEK KSELIPSKVA
610 620 630 640 650
SLSDSYLDQT SSASSMSFRT TGTSETEMSA ICQEYRSTSA TAVTFSDSSL
660 670 680 690 700
LKTQSSDSGN NREALSHGPR KIKATQGQRQ SLSKTEPTQS QRRNSSKTKA
710 720 730 740 750
TIHKRNSSKT KATQSQRRNS SKTRATQGQG QSSSKTEATQ GQRQSSSEIE
760 770 780 790 800
ATQGPRQEPS KTKTTRSPRQ RPRKVKAARG RSWRPSKVDA TQGRSRGLLR
810 820 830 840 850
SSTKTEAFYD SNWSLSKTEY AQGQGQRSSK AEGAQGKSQG MSSTSSKAES
860 870
TWGPSPSLSK TEVDQDLTYY EAV
Length:873
Mass (Da):98,309
Last modified:March 7, 2006 - v2
Checksum:i25E5E5CCEADC0714
GO
Isoform 2 (identifier: Q8NEE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-176: Missing.
     373-417: DCFFQLGNLA...LQEKMGFCEQ → GAQRPGHWGG...ERKEAREEEM
     418-873: Missing.

Note: No experimental confirmation available.
Show »
Length:241
Mass (Da):27,559
Checksum:i456B261F64AE9D99
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti405 – 4051M → T.1 Publication
Corresponds to variant rs17852941 [ dbSNP | Ensembl ].
VAR_025542
Natural varianti588 – 5881E → G.1 Publication
Corresponds to variant rs13298768 [ dbSNP | Ensembl ].
VAR_025543
Natural varianti809 – 8091Y → C.
Corresponds to variant rs4837178 [ dbSNP | Ensembl ].
VAR_052626
Natural varianti872 – 8721A → S.1 Publication
Corresponds to variant rs17852943 [ dbSNP | Ensembl ].
VAR_025544

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 176176Missing in isoform 2. 1 PublicationVSP_056854Add
BLAST
Alternative sequencei373 – 41745DCFFQ…GFCEQ → GAQRPGHWGGGVRGSLAISK APTGHLRPLGGRRKGERKEA REEEM in isoform 2. 1 PublicationVSP_056855Add
BLAST
Alternative sequencei418 – 873456Missing in isoform 2. 1 PublicationVSP_056856Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057342 mRNA. Translation: BAB71437.1.
AK302422 mRNA. Translation: BAG63726.1.
AL162426 Genomic DNA. Translation: CAI41184.1.
BC031281 mRNA. Translation: AAH31281.1.
CCDSiCCDS6875.1. [Q8NEE8-1]
RefSeqiNP_001303966.1. NM_001317037.1.
NP_659402.1. NM_144965.2. [Q8NEE8-1]
UniGeneiHs.642748.

Genome annotation databases

EnsembliENST00000373289; ENSP00000362386; ENSG00000167094. [Q8NEE8-1]
GeneIDi158248.
KEGGihsa:158248.
UCSCiuc004brq.2. human. [Q8NEE8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057342 mRNA. Translation: BAB71437.1.
AK302422 mRNA. Translation: BAG63726.1.
AL162426 Genomic DNA. Translation: CAI41184.1.
BC031281 mRNA. Translation: AAH31281.1.
CCDSiCCDS6875.1. [Q8NEE8-1]
RefSeqiNP_001303966.1. NM_001317037.1.
NP_659402.1. NM_144965.2. [Q8NEE8-1]
UniGeneiHs.642748.

3D structure databases

ProteinModelPortaliQ8NEE8.
SMRiQ8NEE8. Positions 57-122, 280-316, 332-485.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000362386.

PTM databases

iPTMnetiQ8NEE8.
PhosphoSiteiQ8NEE8.

Polymorphism and mutation databases

BioMutaiTTC16.
DMDMi90110783.

Proteomic databases

EPDiQ8NEE8.
PaxDbiQ8NEE8.
PeptideAtlasiQ8NEE8.
PRIDEiQ8NEE8.

Protocols and materials databases

DNASUi158248.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373289; ENSP00000362386; ENSG00000167094. [Q8NEE8-1]
GeneIDi158248.
KEGGihsa:158248.
UCSCiuc004brq.2. human. [Q8NEE8-1]

Organism-specific databases

CTDi158248.
GeneCardsiTTC16.
HGNCiHGNC:26536. TTC16.
HPAiHPA023260.
HPA028714.
neXtProtiNX_Q8NEE8.
PharmGKBiPA134871808.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000004550.
HOGENOMiHOG000294213.
HOVERGENiHBG056302.
InParanoidiQ8NEE8.
OMAiCQEYRST.
OrthoDBiEOG091G03X3.
PhylomeDBiQ8NEE8.
TreeFamiTF350096.

Miscellaneous databases

GenomeRNAii158248.
PROiQ8NEE8.

Gene expression databases

BgeeiENSG00000167094.
CleanExiHS_TTC16.
GenevisibleiQ8NEE8. HS.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 9 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 8 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTC16_HUMAN
AccessioniPrimary (citable) accession number: Q8NEE8
Secondary accession number(s): B4DYG4
, B5ME24, Q5JU66, Q96M72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.