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Protein

Tetratricopeptide repeat protein 16

Gene

TTC16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 16
Short name:
TPR repeat protein 16
Gene namesi
Name:TTC16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000167094.15
HGNCiHGNC:26536 TTC16
neXtProtiNX_Q8NEE8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167094
PharmGKBiPA134871808

Polymorphism and mutation databases

BioMutaiTTC16
DMDMi90110783

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001064031 – 873Tetratricopeptide repeat protein 16Add BLAST873

Proteomic databases

EPDiQ8NEE8
PaxDbiQ8NEE8
PeptideAtlasiQ8NEE8
PRIDEiQ8NEE8

PTM databases

iPTMnetiQ8NEE8
PhosphoSitePlusiQ8NEE8

Expressioni

Gene expression databases

BgeeiENSG00000167094
CleanExiHS_TTC16
GenevisibleiQ8NEE8 HS

Interactioni

Protein-protein interaction databases

IntActiQ8NEE8, 1 interactor
STRINGi9606.ENSP00000362386

Structurei

3D structure databases

ProteinModelPortaliQ8NEE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati61 – 94TPR 1Add BLAST34
Repeati96 – 128TPR 2Add BLAST33
Repeati136 – 169TPR 3Add BLAST34
Repeati251 – 284TPR 4Add BLAST34
Repeati285 – 318TPR 5Add BLAST34
Repeati331 – 364TPR 6Add BLAST34
Repeati365 – 398TPR 7Add BLAST34
Repeati406 – 439TPR 8Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000004550
HOGENOMiHOG000294213
HOVERGENiHBG056302
InParanoidiQ8NEE8
OMAiEQCAFLD
OrthoDBiEOG091G03X3
PhylomeDBiQ8NEE8
TreeFamiTF350096

Family and domain databases

Gene3Di1.25.40.10, 4 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00515 TPR_1, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 9 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 8 hits
PS50293 TPR_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NEE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDSDEDALK VDQGPSRDIP KPWVIPAPKG ILQHIFGTSH VFQSICDVKP
60 70 80 90 100
KVTGLTVPLK VREYYSRGQQ CLEQADWETA VLLFSRALHL DPQLVDFYAL
110 120 130 140 150
RAEAYLQLCD FSSAAQNLRR AYSLQQDNCK HLERLTFVLY LQGQCLFEQC
160 170 180 190 200
AFLDALNVFS HAAELQPEKP CFRYRCMACL LALKQHQACL TLITNELKQD
210 220 230 240 250
TTNADVYIFR ARLYNFLQKP HLCYRDLHSA LLLNPKHPQA RMLLQKMVAQ
260 270 280 290 300
AQQARQDAGI LAVQGKLQHA LQRINRAIEN NPLDPSLFLF RGTMYRRLQE
310 320 330 340 350
FDGAVEDFLK VLDMVTEDQE DMVRQAQRQL LLTYNDFAVH CYRQGAYQEG
360 370 380 390 400
VLLLNKALRD EQQEKGLYIN RGDCFFQLGN LAFAEADYQQ ALALSPQDEG
410 420 430 440 450
ANTRMGLLQE KMGFCEQRRK QFQKAENHFS TAIRHNPQKA QYYLYRAKSR
460 470 480 490 500
QLLQNIFGAR QDVATVLLLN PKQPKLSLLM TNLFPGMSVE EVLSTQIAHL
510 520 530 540 550
ARLQLEQMVE GSLQAGSPQG IVGMLKRHEL ERQKALALQH SWKQGEPLIA
560 570 580 590 600
TSEELKATPE IPQVKPGSSE GEAEAPEEEE EKEKEKKEEK KSELIPSKVA
610 620 630 640 650
SLSDSYLDQT SSASSMSFRT TGTSETEMSA ICQEYRSTSA TAVTFSDSSL
660 670 680 690 700
LKTQSSDSGN NREALSHGPR KIKATQGQRQ SLSKTEPTQS QRRNSSKTKA
710 720 730 740 750
TIHKRNSSKT KATQSQRRNS SKTRATQGQG QSSSKTEATQ GQRQSSSEIE
760 770 780 790 800
ATQGPRQEPS KTKTTRSPRQ RPRKVKAARG RSWRPSKVDA TQGRSRGLLR
810 820 830 840 850
SSTKTEAFYD SNWSLSKTEY AQGQGQRSSK AEGAQGKSQG MSSTSSKAES
860 870
TWGPSPSLSK TEVDQDLTYY EAV
Length:873
Mass (Da):98,309
Last modified:March 7, 2006 - v2
Checksum:i25E5E5CCEADC0714
GO
Isoform 2 (identifier: Q8NEE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-176: Missing.
     373-417: DCFFQLGNLA...LQEKMGFCEQ → GAQRPGHWGG...ERKEAREEEM
     418-873: Missing.

Note: No experimental confirmation available.
Show »
Length:241
Mass (Da):27,559
Checksum:i456B261F64AE9D99
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025542405M → T1 PublicationCorresponds to variant dbSNP:rs17852941Ensembl.1
Natural variantiVAR_025543588E → G1 PublicationCorresponds to variant dbSNP:rs13298768Ensembl.1
Natural variantiVAR_052626809Y → C. Corresponds to variant dbSNP:rs4837178Ensembl.1
Natural variantiVAR_025544872A → S1 PublicationCorresponds to variant dbSNP:rs17852943Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0568541 – 176Missing in isoform 2. 1 PublicationAdd BLAST176
Alternative sequenceiVSP_056855373 – 417DCFFQ…GFCEQ → GAQRPGHWGGGVRGSLAISK APTGHLRPLGGRRKGERKEA REEEM in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_056856418 – 873Missing in isoform 2. 1 PublicationAdd BLAST456

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057342 mRNA Translation: BAB71437.1
AK302422 mRNA Translation: BAG63726.1
AL162426 Genomic DNA No translation available.
BC031281 mRNA Translation: AAH31281.1
CCDSiCCDS6875.1 [Q8NEE8-1]
RefSeqiNP_001303966.1, NM_001317037.1
NP_659402.1, NM_144965.2 [Q8NEE8-1]
UniGeneiHs.642748

Genome annotation databases

EnsembliENST00000373289; ENSP00000362386; ENSG00000167094 [Q8NEE8-1]
GeneIDi158248
KEGGihsa:158248
UCSCiuc004brq.2 human [Q8NEE8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTTC16_HUMAN
AccessioniPrimary (citable) accession number: Q8NEE8
Secondary accession number(s): B4DYG4
, B5ME24, Q5JU66, Q96M72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 7, 2006
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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