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Protein

F-box/LRR-repeat protein 13

Gene

FBXL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 13
Alternative name(s):
F-box and leucine-rich repeat protein 13
Gene namesi
Name:FBXL13
Synonyms:FBL13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21658. FBXL13.

Pathology & Biotechi

Organism-specific databases

DisGeNETi222235.
OpenTargetsiENSG00000161040.
PharmGKBiPA134938720.

Polymorphism and mutation databases

BioMutaiFBXL13.
DMDMi311033450.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198591 – 735F-box/LRR-repeat protein 13Add BLAST735

Proteomic databases

MaxQBiQ8NEE6.
PaxDbiQ8NEE6.
PRIDEiQ8NEE6.

PTM databases

iPTMnetiQ8NEE6.
PhosphoSitePlusiQ8NEE6.
SwissPalmiQ8NEE6.

Expressioni

Gene expression databases

BgeeiENSG00000161040.
ExpressionAtlasiQ8NEE6. baseline and differential.
GenevisibleiQ8NEE6. HS.

Organism-specific databases

HPAiHPA057232.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi128792. 2 interactors.
IntActiQ8NEE6. 2 interactors.
MINTiMINT-4779619.
STRINGi9606.ENSP00000321927.

Structurei

3D structure databases

ProteinModelPortaliQ8NEE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini152 – 198F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati230 – 254LRR 1Add BLAST25
Repeati255 – 280LRR 2Add BLAST26
Repeati281 – 305LRR 3Add BLAST25
Repeati306 – 333LRR 4Add BLAST28
Repeati334 – 359LRR 5Add BLAST26
Repeati360 – 385LRR 6Add BLAST26
Repeati386 – 406LRR 7Add BLAST21
Repeati410 – 435LRR 8Add BLAST26
Repeati436 – 460LRR 9Add BLAST25
Repeati461 – 488LRR 10Add BLAST28
Repeati489 – 514LRR 11Add BLAST26
Repeati515 – 538LRR 12Add BLAST24
Repeati539 – 563LRR 13Add BLAST25
Repeati564 – 589LRR 14Add BLAST26
Repeati590 – 615LRR 15Add BLAST26
Repeati616 – 641LRR 16Add BLAST26
Repeati642 – 667LRR 17Add BLAST26

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 17 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT20. Eukaryota.
ENOG410XPA4. LUCA.
GeneTreeiENSGT00760000119059.
HOVERGENiHBG051673.
InParanoidiQ8NEE6.
KOiK10279.
OMAiPRWFGYD.
OrthoDBiEOG091G08EL.
PhylomeDBiQ8NEE6.
TreeFamiTF329711.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF13516. LRR_6. 5 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 14 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NEE6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPELMIKAC SFYTGHLVKT HFCTWRDIAR TNENVVLAEK MNRAVTCYNF
60 70 80 90 100
RLQKSVFHHW HSYMEDQKEK LKNILLRIQQ IIYCHKLTII LTKWRNTARH
110 120 130 140 150
KSKKKEDELI LKHELQLKKW KNRLILKRAA AEESNFPERS SSEVFLVDET
160 170 180 190 200
LKCDISLLPE RAILQIFFYL SLKDVIICGQ VNHAWMLMTQ LNSLWNAIDF
210 220 230 240 250
SSVKNVIPDK YIVSTLQRWR LNVLRLNFRG CLLRPKTFRS VSHCRNLQEL
260 270 280 290 300
NVSDCPTFTD ESMRHISEGC PGVLCLNLSN TTITNRTMRL LPRHFHNLQN
310 320 330 340 350
LSLAYCRRFT DKGLQYLNLG NGCHKLIYLD LSGCTQISVQ GFRYIANSCT
360 370 380 390 400
GIMHLTINDM PTLTDNCVKA LVEKCSRITS LVFTGAPHIS DCTFRALSAC
410 420 430 440 450
KLRKIRFEGN KRVTDASFKF IDKNYPNLSH IYMADCKGIT DSSLRSLSPL
460 470 480 490 500
KQLTVLNLAN CVRIGDMGLK QFLDGPASMR IRELNLSNCV RLSDASVMKL
510 520 530 540 550
SERCPNLNYL SLRNCEHLTA QGIGYIVNIF SLVSIDLSGT DISNEGLNVL
560 570 580 590 600
SRHKKLKELS VSECYRITDD GIQAFCKSSL ILEHLDVSYC SQLSDMIIKA
610 620 630 640 650
LAIYCINLTS LSIAGCPKIT DSAMEMLSAK CHYLHILDIS GCVLLTDQIL
660 670 680 690 700
EDLQIGCKQL RILKMQYCTN ISKKAAQRMS SKVQQQEYNT NDPPRWFGYD
710 720 730
REGNPVTELD NITSSKGALE LTVKKSTYSS EDQAA
Length:735
Mass (Da):83,924
Last modified:November 2, 2010 - v3
Checksum:i27F92DC4693C2581
GO
Isoform 2 (identifier: Q8NEE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     546-573: Missing.

Note: No experimental confirmation available.
Show »
Length:707
Mass (Da):80,739
Checksum:i2C5A4F17C11B7734
GO
Isoform 3 (identifier: Q8NEE6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-618: Missing.

Show »
Length:690
Mass (Da):79,064
Checksum:iA9C6D44C07E0CBD7
GO
Isoform 4 (identifier: Q8NEE6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     337-618: Missing.

Show »
Length:453
Mass (Da):52,734
Checksum:iE3E226E465BF54C9
GO

Sequence cautioni

The sequence CAD28506 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110I → V in AAR13262 (PubMed:15820312).Curated1
Sequence conflicti337I → V in AAR13263 (PubMed:15820312).Curated1
Sequence conflicti496S → F in CAD28506 (PubMed:17974005).Curated1
Sequence conflicti674K → E in AAR13263 (PubMed:15820312).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02148074I → M.2 PublicationsCorresponds to variant rs7805950dbSNPEnsembl.1
Natural variantiVAR_031426313G → A.Corresponds to variant rs17135923dbSNPEnsembl.1
Natural variantiVAR_031427535I → V.Corresponds to variant rs17135873dbSNPEnsembl.1
Natural variantiVAR_031428565Y → C.Corresponds to variant rs17136118dbSNPEnsembl.1
Natural variantiVAR_031429692D → G.1 PublicationCorresponds to variant rs17852944dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013003337 – 618Missing in isoform 4. 1 PublicationAdd BLAST282
Alternative sequenceiVSP_013004546 – 573Missing in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_013005574 – 618Missing in isoform 3. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359238 mRNA. Translation: AAR13262.1.
AY359239 mRNA. Translation: AAR13263.1.
AK097537 mRNA. Translation: BAC05092.1.
AC005250 Genomic DNA. Translation: AAP22333.1.
AC006477 Genomic DNA. Translation: AAS00354.1.
AC073127 Genomic DNA. No translation available.
BC020572 mRNA. Translation: AAH20572.2.
BC020575 mRNA. Translation: AAH20575.2.
BC031285 mRNA. Translation: AAH31285.1.
AL713709 mRNA. Translation: CAD28506.1. Different initiation.
CCDSiCCDS47678.1. [Q8NEE6-3]
CCDS5726.1. [Q8NEE6-1]
CCDS75649.1. [Q8NEE6-2]
RefSeqiNP_001104508.1. NM_001111038.1. [Q8NEE6-3]
NP_001274079.1. NM_001287150.1. [Q8NEE6-2]
NP_659469.3. NM_145032.3. [Q8NEE6-1]
XP_005250266.1. XM_005250209.2. [Q8NEE6-1]
XP_011514232.1. XM_011515930.2. [Q8NEE6-1]
XP_016867342.1. XM_017011853.1. [Q8NEE6-1]
UniGeneiHs.660029.

Genome annotation databases

EnsembliENST00000313221; ENSP00000321927; ENSG00000161040. [Q8NEE6-1]
ENST00000379305; ENSP00000368607; ENSG00000161040. [Q8NEE6-2]
ENST00000436908; ENSP00000388608; ENSG00000161040. [Q8NEE6-1]
ENST00000455112; ENSP00000391550; ENSG00000161040. [Q8NEE6-3]
ENST00000456695; ENSP00000409716; ENSG00000161040. [Q8NEE6-4]
GeneIDi222235.
KEGGihsa:222235.
UCSCiuc003vaq.3. human. [Q8NEE6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359238 mRNA. Translation: AAR13262.1.
AY359239 mRNA. Translation: AAR13263.1.
AK097537 mRNA. Translation: BAC05092.1.
AC005250 Genomic DNA. Translation: AAP22333.1.
AC006477 Genomic DNA. Translation: AAS00354.1.
AC073127 Genomic DNA. No translation available.
BC020572 mRNA. Translation: AAH20572.2.
BC020575 mRNA. Translation: AAH20575.2.
BC031285 mRNA. Translation: AAH31285.1.
AL713709 mRNA. Translation: CAD28506.1. Different initiation.
CCDSiCCDS47678.1. [Q8NEE6-3]
CCDS5726.1. [Q8NEE6-1]
CCDS75649.1. [Q8NEE6-2]
RefSeqiNP_001104508.1. NM_001111038.1. [Q8NEE6-3]
NP_001274079.1. NM_001287150.1. [Q8NEE6-2]
NP_659469.3. NM_145032.3. [Q8NEE6-1]
XP_005250266.1. XM_005250209.2. [Q8NEE6-1]
XP_011514232.1. XM_011515930.2. [Q8NEE6-1]
XP_016867342.1. XM_017011853.1. [Q8NEE6-1]
UniGeneiHs.660029.

3D structure databases

ProteinModelPortaliQ8NEE6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128792. 2 interactors.
IntActiQ8NEE6. 2 interactors.
MINTiMINT-4779619.
STRINGi9606.ENSP00000321927.

PTM databases

iPTMnetiQ8NEE6.
PhosphoSitePlusiQ8NEE6.
SwissPalmiQ8NEE6.

Polymorphism and mutation databases

BioMutaiFBXL13.
DMDMi311033450.

Proteomic databases

MaxQBiQ8NEE6.
PaxDbiQ8NEE6.
PRIDEiQ8NEE6.

Protocols and materials databases

DNASUi222235.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313221; ENSP00000321927; ENSG00000161040. [Q8NEE6-1]
ENST00000379305; ENSP00000368607; ENSG00000161040. [Q8NEE6-2]
ENST00000436908; ENSP00000388608; ENSG00000161040. [Q8NEE6-1]
ENST00000455112; ENSP00000391550; ENSG00000161040. [Q8NEE6-3]
ENST00000456695; ENSP00000409716; ENSG00000161040. [Q8NEE6-4]
GeneIDi222235.
KEGGihsa:222235.
UCSCiuc003vaq.3. human. [Q8NEE6-1]

Organism-specific databases

CTDi222235.
DisGeNETi222235.
GeneCardsiFBXL13.
H-InvDBHIX0018805.
HGNCiHGNC:21658. FBXL13.
HPAiHPA057232.
MIMi609080. gene.
neXtProtiNX_Q8NEE6.
OpenTargetsiENSG00000161040.
PharmGKBiPA134938720.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT20. Eukaryota.
ENOG410XPA4. LUCA.
GeneTreeiENSGT00760000119059.
HOVERGENiHBG051673.
InParanoidiQ8NEE6.
KOiK10279.
OMAiPRWFGYD.
OrthoDBiEOG091G08EL.
PhylomeDBiQ8NEE6.
TreeFamiTF329711.

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiFBXL13. human.
GenomeRNAii222235.
PROiQ8NEE6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161040.
ExpressionAtlasiQ8NEE6. baseline and differential.
GenevisibleiQ8NEE6. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF13516. LRR_6. 5 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 14 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFXL13_HUMAN
AccessioniPrimary (citable) accession number: Q8NEE6
Secondary accession number(s): C9J565
, C9J566, Q6UVW7, Q6UVW8, Q75MN5, Q86UJ5, Q8N7Y4, Q8TCL2, Q8WUF9, Q8WUG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 2, 2010
Last modified: November 2, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.