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Protein

F-box/LRR-repeat protein 13

Gene

FBXL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 13
Alternative name(s):
F-box and leucine-rich repeat protein 13
Gene namesi
Name:FBXL13
Synonyms:FBL13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21658. FBXL13.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134938720.

Polymorphism and mutation databases

BioMutaiFBXL13.
DMDMi311033450.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735F-box/LRR-repeat protein 13PRO_0000119859Add
BLAST

Proteomic databases

MaxQBiQ8NEE6.
PaxDbiQ8NEE6.
PRIDEiQ8NEE6.

PTM databases

PhosphoSiteiQ8NEE6.

Expressioni

Gene expression databases

BgeeiQ8NEE6.
ExpressionAtlasiQ8NEE6. baseline and differential.
GenevisibleiQ8NEE6. HS.

Organism-specific databases

HPAiHPA057232.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi128792. 2 interactions.
IntActiQ8NEE6. 2 interactions.
MINTiMINT-4779619.
STRINGi9606.ENSP00000321927.

Structurei

3D structure databases

ProteinModelPortaliQ8NEE6.
SMRiQ8NEE6. Positions 269-305, 481-670.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini152 – 19847F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati230 – 25425LRR 1Add
BLAST
Repeati255 – 28026LRR 2Add
BLAST
Repeati281 – 30525LRR 3Add
BLAST
Repeati306 – 33328LRR 4Add
BLAST
Repeati334 – 35926LRR 5Add
BLAST
Repeati360 – 38526LRR 6Add
BLAST
Repeati386 – 40621LRR 7Add
BLAST
Repeati410 – 43526LRR 8Add
BLAST
Repeati436 – 46025LRR 9Add
BLAST
Repeati461 – 48828LRR 10Add
BLAST
Repeati489 – 51426LRR 11Add
BLAST
Repeati515 – 53824LRR 12Add
BLAST
Repeati539 – 56325LRR 13Add
BLAST
Repeati564 – 58926LRR 14Add
BLAST
Repeati590 – 61526LRR 15Add
BLAST
Repeati616 – 64126LRR 16Add
BLAST
Repeati642 – 66726LRR 17Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 17 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT20. Eukaryota.
ENOG410XPA4. LUCA.
GeneTreeiENSGT00760000119059.
HOVERGENiHBG051673.
InParanoidiQ8NEE6.
KOiK10279.
OMAiQIGCKQL.
OrthoDBiEOG73NG2Q.
PhylomeDBiQ8NEE6.
TreeFamiTF329711.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF13516. LRR_6. 5 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 14 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NEE6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPELMIKAC SFYTGHLVKT HFCTWRDIAR TNENVVLAEK MNRAVTCYNF
60 70 80 90 100
RLQKSVFHHW HSYMEDQKEK LKNILLRIQQ IIYCHKLTII LTKWRNTARH
110 120 130 140 150
KSKKKEDELI LKHELQLKKW KNRLILKRAA AEESNFPERS SSEVFLVDET
160 170 180 190 200
LKCDISLLPE RAILQIFFYL SLKDVIICGQ VNHAWMLMTQ LNSLWNAIDF
210 220 230 240 250
SSVKNVIPDK YIVSTLQRWR LNVLRLNFRG CLLRPKTFRS VSHCRNLQEL
260 270 280 290 300
NVSDCPTFTD ESMRHISEGC PGVLCLNLSN TTITNRTMRL LPRHFHNLQN
310 320 330 340 350
LSLAYCRRFT DKGLQYLNLG NGCHKLIYLD LSGCTQISVQ GFRYIANSCT
360 370 380 390 400
GIMHLTINDM PTLTDNCVKA LVEKCSRITS LVFTGAPHIS DCTFRALSAC
410 420 430 440 450
KLRKIRFEGN KRVTDASFKF IDKNYPNLSH IYMADCKGIT DSSLRSLSPL
460 470 480 490 500
KQLTVLNLAN CVRIGDMGLK QFLDGPASMR IRELNLSNCV RLSDASVMKL
510 520 530 540 550
SERCPNLNYL SLRNCEHLTA QGIGYIVNIF SLVSIDLSGT DISNEGLNVL
560 570 580 590 600
SRHKKLKELS VSECYRITDD GIQAFCKSSL ILEHLDVSYC SQLSDMIIKA
610 620 630 640 650
LAIYCINLTS LSIAGCPKIT DSAMEMLSAK CHYLHILDIS GCVLLTDQIL
660 670 680 690 700
EDLQIGCKQL RILKMQYCTN ISKKAAQRMS SKVQQQEYNT NDPPRWFGYD
710 720 730
REGNPVTELD NITSSKGALE LTVKKSTYSS EDQAA
Length:735
Mass (Da):83,924
Last modified:November 2, 2010 - v3
Checksum:i27F92DC4693C2581
GO
Isoform 2 (identifier: Q8NEE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     546-573: Missing.

Note: No experimental confirmation available.
Show »
Length:707
Mass (Da):80,739
Checksum:i2C5A4F17C11B7734
GO
Isoform 3 (identifier: Q8NEE6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-618: Missing.

Show »
Length:690
Mass (Da):79,064
Checksum:iA9C6D44C07E0CBD7
GO
Isoform 4 (identifier: Q8NEE6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     337-618: Missing.

Show »
Length:453
Mass (Da):52,734
Checksum:iE3E226E465BF54C9
GO

Sequence cautioni

The sequence CAD28506.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101I → V in AAR13262 (PubMed:15820312).Curated
Sequence conflicti337 – 3371I → V in AAR13263 (PubMed:15820312).Curated
Sequence conflicti496 – 4961S → F in CAD28506 (PubMed:17974005).Curated
Sequence conflicti674 – 6741K → E in AAR13263 (PubMed:15820312).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti74 – 741I → M.2 Publications
Corresponds to variant rs7805950 [ dbSNP | Ensembl ].
VAR_021480
Natural varianti313 – 3131G → A.
Corresponds to variant rs17135923 [ dbSNP | Ensembl ].
VAR_031426
Natural varianti535 – 5351I → V.
Corresponds to variant rs17135873 [ dbSNP | Ensembl ].
VAR_031427
Natural varianti565 – 5651Y → C.
Corresponds to variant rs17136118 [ dbSNP | Ensembl ].
VAR_031428
Natural varianti692 – 6921D → G.1 Publication
Corresponds to variant rs17852944 [ dbSNP | Ensembl ].
VAR_031429

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei337 – 618282Missing in isoform 4. 1 PublicationVSP_013003Add
BLAST
Alternative sequencei546 – 57328Missing in isoform 2. 1 PublicationVSP_013004Add
BLAST
Alternative sequencei574 – 61845Missing in isoform 3. 1 PublicationVSP_013005Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359238 mRNA. Translation: AAR13262.1.
AY359239 mRNA. Translation: AAR13263.1.
AK097537 mRNA. Translation: BAC05092.1.
AC005250 Genomic DNA. Translation: AAP22333.1.
AC006477 Genomic DNA. Translation: AAS00354.1.
AC073127 Genomic DNA. No translation available.
BC020572 mRNA. Translation: AAH20572.2.
BC020575 mRNA. Translation: AAH20575.2.
BC031285 mRNA. Translation: AAH31285.1.
AL713709 mRNA. Translation: CAD28506.1. Different initiation.
CCDSiCCDS47678.1. [Q8NEE6-3]
CCDS5726.1. [Q8NEE6-1]
CCDS75649.1. [Q8NEE6-2]
RefSeqiNP_001104508.1. NM_001111038.1. [Q8NEE6-3]
NP_001274079.1. NM_001287150.1. [Q8NEE6-2]
NP_659469.3. NM_145032.3. [Q8NEE6-1]
XP_005250266.1. XM_005250209.1. [Q8NEE6-1]
XP_011514232.1. XM_011515930.1. [Q8NEE6-1]
XP_011514233.1. XM_011515931.1. [Q8NEE6-1]
UniGeneiHs.660029.

Genome annotation databases

EnsembliENST00000313221; ENSP00000321927; ENSG00000161040. [Q8NEE6-1]
ENST00000379305; ENSP00000368607; ENSG00000161040. [Q8NEE6-2]
ENST00000436908; ENSP00000388608; ENSG00000161040. [Q8NEE6-1]
ENST00000455112; ENSP00000391550; ENSG00000161040. [Q8NEE6-3]
ENST00000456695; ENSP00000409716; ENSG00000161040. [Q8NEE6-4]
GeneIDi222235.
KEGGihsa:222235.
UCSCiuc003vaq.3. human. [Q8NEE6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359238 mRNA. Translation: AAR13262.1.
AY359239 mRNA. Translation: AAR13263.1.
AK097537 mRNA. Translation: BAC05092.1.
AC005250 Genomic DNA. Translation: AAP22333.1.
AC006477 Genomic DNA. Translation: AAS00354.1.
AC073127 Genomic DNA. No translation available.
BC020572 mRNA. Translation: AAH20572.2.
BC020575 mRNA. Translation: AAH20575.2.
BC031285 mRNA. Translation: AAH31285.1.
AL713709 mRNA. Translation: CAD28506.1. Different initiation.
CCDSiCCDS47678.1. [Q8NEE6-3]
CCDS5726.1. [Q8NEE6-1]
CCDS75649.1. [Q8NEE6-2]
RefSeqiNP_001104508.1. NM_001111038.1. [Q8NEE6-3]
NP_001274079.1. NM_001287150.1. [Q8NEE6-2]
NP_659469.3. NM_145032.3. [Q8NEE6-1]
XP_005250266.1. XM_005250209.1. [Q8NEE6-1]
XP_011514232.1. XM_011515930.1. [Q8NEE6-1]
XP_011514233.1. XM_011515931.1. [Q8NEE6-1]
UniGeneiHs.660029.

3D structure databases

ProteinModelPortaliQ8NEE6.
SMRiQ8NEE6. Positions 269-305, 481-670.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128792. 2 interactions.
IntActiQ8NEE6. 2 interactions.
MINTiMINT-4779619.
STRINGi9606.ENSP00000321927.

PTM databases

PhosphoSiteiQ8NEE6.

Polymorphism and mutation databases

BioMutaiFBXL13.
DMDMi311033450.

Proteomic databases

MaxQBiQ8NEE6.
PaxDbiQ8NEE6.
PRIDEiQ8NEE6.

Protocols and materials databases

DNASUi222235.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313221; ENSP00000321927; ENSG00000161040. [Q8NEE6-1]
ENST00000379305; ENSP00000368607; ENSG00000161040. [Q8NEE6-2]
ENST00000436908; ENSP00000388608; ENSG00000161040. [Q8NEE6-1]
ENST00000455112; ENSP00000391550; ENSG00000161040. [Q8NEE6-3]
ENST00000456695; ENSP00000409716; ENSG00000161040. [Q8NEE6-4]
GeneIDi222235.
KEGGihsa:222235.
UCSCiuc003vaq.3. human. [Q8NEE6-1]

Organism-specific databases

CTDi222235.
GeneCardsiFBXL13.
H-InvDBHIX0018805.
HGNCiHGNC:21658. FBXL13.
HPAiHPA057232.
MIMi609080. gene.
neXtProtiNX_Q8NEE6.
PharmGKBiPA134938720.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT20. Eukaryota.
ENOG410XPA4. LUCA.
GeneTreeiENSGT00760000119059.
HOVERGENiHBG051673.
InParanoidiQ8NEE6.
KOiK10279.
OMAiQIGCKQL.
OrthoDBiEOG73NG2Q.
PhylomeDBiQ8NEE6.
TreeFamiTF329711.

Miscellaneous databases

ChiTaRSiFBXL13. human.
GenomeRNAii222235.
NextBioi91581.
PROiQ8NEE6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NEE6.
ExpressionAtlasiQ8NEE6. baseline and differential.
GenevisibleiQ8NEE6. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF13516. LRR_6. 5 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 14 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22."
    Curtiss N.P., Bonifas J.M., Lauchle J.O., Balkman J.D., Kratz C.P., Emerling B.M., Green E.D., Le Beau M.M., Shannon K.M.
    Genomics 85:600-607(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-74.
    Tissue: Testis.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS MET-74 AND GLY-692.
    Tissue: Kidney, Liver and Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 285-735.
    Tissue: Testis.

Entry informationi

Entry nameiFXL13_HUMAN
AccessioniPrimary (citable) accession number: Q8NEE6
Secondary accession number(s): C9J565
, C9J566, Q6UVW7, Q6UVW8, Q75MN5, Q86UJ5, Q8N7Y4, Q8TCL2, Q8WUF9, Q8WUG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 2, 2010
Last modified: May 11, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.