Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione S-transferase C-terminal domain-containing protein

Gene

GSTCD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase C-terminal domain-containing protein
Gene namesi
Name:GSTCD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25806. GSTCD.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596427.

Polymorphism and mutation databases

BioMutaiGSTCD.
DMDMi167008865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 633633Glutathione S-transferase C-terminal domain-containing proteinPRO_0000316952Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei233 – 2331PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NEC7.
MaxQBiQ8NEC7.
PaxDbiQ8NEC7.
PeptideAtlasiQ8NEC7.
PRIDEiQ8NEC7.

PTM databases

iPTMnetiQ8NEC7.
PhosphoSiteiQ8NEC7.

Expressioni

Tissue specificityi

Widely expressed in cell types relevant to airway function, including airway smooth muscle cells and epithelial cells.1 Publication

Gene expression databases

BgeeiENSG00000138780.
CleanExiHS_GSTCD.
ExpressionAtlasiQ8NEC7. baseline and differential.
GenevisibleiQ8NEC7. HS.

Organism-specific databases

HPAiHPA046160.
HPA061782.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KDM1AO603412EBI-8469616,EBI-710124
PRMT6Q96LA82EBI-8469616,EBI-912440

Protein-protein interaction databases

BioGridi122903. 13 interactions.
IntActiQ8NEC7. 8 interactions.
MINTiMINT-6779113.
STRINGi9606.ENSP00000353695.

Structurei

3D structure databases

ProteinModelPortaliQ8NEC7.
SMRiQ8NEC7. Positions 439-541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini130 – 332203GST C-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the GSTCD family.Curated
Contains 1 GST C-terminal domain.Curated

Phylogenomic databases

eggNOGiENOG410IDXE. Eukaryota.
ENOG410ZVJE. LUCA.
GeneTreeiENSGT00390000004446.
HOGENOMiHOG000038504.
HOVERGENiHBG107970.
InParanoidiQ8NEC7.
OMAiPRNRIYT.
OrthoDBiEOG091G098R.
PhylomeDBiQ8NEC7.
TreeFamiTF324238.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.50.150. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR025714. Methyltranfer_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF13679. Methyltransf_32. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NEC7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAIKKSLTE EEYLYLDFSH QTEGCIFPLH TSVTLFLLSY CDCKIFKICL
60 70 80 90 100
VVTKEVSRDS SLLRDDLIQD VEIQIISRQE LPPIVQNCCL PAVVERSDNF
110 120 130 140 150
CRAGLAVVLR HIIQKSYEAD PLKKELLELL GFKKTCLKAC AEVSQWTRLC
160 170 180 190 200
ELTIPLAIEN FLRESSDQPP TIPVEILQLE KKLSEPVRVH NDDKLRRQKL
210 220 230 240 250
KQQKADGVGP PLTKGKAKSK VHTQETSEGL DSSSKSLELK VAFSKLTVQE
260 270 280 290 300
EPATTNREPS HIRKAKASDL PPLEHVFAEG LYFTLADIVL LPCIHHFLVI
310 320 330 340 350
ISRKFSEKLV EFPLLASWYQ RIQEVPGVKT AASKCGIQFL HLPKLLTTST
360 370 380 390 400
EQHPNLCEVP GVEEQSDPLF IGGPRPTMAK LMEKGIEVMF SPHPCPTWTL
410 420 430 440 450
DWNVLPAAVS PKEGKMSSDR ALRKQQQLNN LVYVVTNQAK PGDRIVDFCS
460 470 480 490 500
GGGHVGIVLA HMLPSCQVTL IENKELSLIR AKKRSDELGL SNIWFIQANM
510 520 530 540 550
EYFTGMFNIG VALHACGVAT DMVIEHCIKT RASFVTCPCC YGFIQNTSKF
560 570 580 590 600
NFPKSEQFKK TLSYKEHMIL CRFADQTAVQ LPPQRRLIGK QCMCLVDLDR
610 620 630
ARAAEECGYS VQVISMEPES CSPKNNMIVG VPI
Length:633
Mass (Da):71,079
Last modified:February 5, 2008 - v2
Checksum:i709B8EA78BF0E732
GO
Isoform 2 (identifier: Q8NEC7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-141: Missing.

Note: No experimental confirmation available.
Show »
Length:546
Mass (Da):61,289
Checksum:i44747D4ED4B079CF
GO

Sequence cautioni

The sequence BAB14532 differs from that shown.Intron retention.Curated
The sequence BX648355 differs from that shown. Reason: Frameshift at position 474. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101E → G in BAF85044 (PubMed:14702039).Curated
Sequence conflicti74 – 741Q → R in BAB14532 (PubMed:14702039).Curated
Sequence conflicti331 – 3311Missing in AAH32942 (PubMed:15489334).Curated
Sequence conflicti415 – 4151K → R in BAF85044 (PubMed:14702039).Curated
Sequence conflicti474 – 4741K → R in BX648355 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei55 – 14187Missing in isoform 2. 1 PublicationVSP_045228Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023335 mRNA. Translation: BAB14532.1. Sequence problems.
AK292355 mRNA. Translation: BAF85044.1.
BX648355 mRNA. No translation available.
AC008243 Genomic DNA. No translation available.
AC105391 Genomic DNA. No translation available.
BC032942 mRNA. Translation: AAH32942.1.
CCDSiCCDS3672.2. [Q8NEC7-3]
CCDS43257.1. [Q8NEC7-1]
RefSeqiNP_001026890.2. NM_001031720.3. [Q8NEC7-1]
NP_079027.2. NM_024751.3. [Q8NEC7-3]
XP_005263279.1. XM_005263222.3. [Q8NEC7-1]
XP_011530550.1. XM_011532248.2. [Q8NEC7-1]
XP_011530551.1. XM_011532249.2. [Q8NEC7-1]
XP_011530554.1. XM_011532252.2. [Q8NEC7-1]
UniGeneiHs.161429.

Genome annotation databases

EnsembliENST00000360505; ENSP00000353695; ENSG00000138780. [Q8NEC7-1]
ENST00000394728; ENSP00000378216; ENSG00000138780. [Q8NEC7-1]
ENST00000394730; ENSP00000378218; ENSG00000138780. [Q8NEC7-3]
ENST00000515279; ENSP00000422354; ENSG00000138780. [Q8NEC7-1]
GeneIDi79807.
KEGGihsa:79807.
UCSCiuc003hxy.4. human. [Q8NEC7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023335 mRNA. Translation: BAB14532.1. Sequence problems.
AK292355 mRNA. Translation: BAF85044.1.
BX648355 mRNA. No translation available.
AC008243 Genomic DNA. No translation available.
AC105391 Genomic DNA. No translation available.
BC032942 mRNA. Translation: AAH32942.1.
CCDSiCCDS3672.2. [Q8NEC7-3]
CCDS43257.1. [Q8NEC7-1]
RefSeqiNP_001026890.2. NM_001031720.3. [Q8NEC7-1]
NP_079027.2. NM_024751.3. [Q8NEC7-3]
XP_005263279.1. XM_005263222.3. [Q8NEC7-1]
XP_011530550.1. XM_011532248.2. [Q8NEC7-1]
XP_011530551.1. XM_011532249.2. [Q8NEC7-1]
XP_011530554.1. XM_011532252.2. [Q8NEC7-1]
UniGeneiHs.161429.

3D structure databases

ProteinModelPortaliQ8NEC7.
SMRiQ8NEC7. Positions 439-541.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122903. 13 interactions.
IntActiQ8NEC7. 8 interactions.
MINTiMINT-6779113.
STRINGi9606.ENSP00000353695.

PTM databases

iPTMnetiQ8NEC7.
PhosphoSiteiQ8NEC7.

Polymorphism and mutation databases

BioMutaiGSTCD.
DMDMi167008865.

Proteomic databases

EPDiQ8NEC7.
MaxQBiQ8NEC7.
PaxDbiQ8NEC7.
PeptideAtlasiQ8NEC7.
PRIDEiQ8NEC7.

Protocols and materials databases

DNASUi79807.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360505; ENSP00000353695; ENSG00000138780. [Q8NEC7-1]
ENST00000394728; ENSP00000378216; ENSG00000138780. [Q8NEC7-1]
ENST00000394730; ENSP00000378218; ENSG00000138780. [Q8NEC7-3]
ENST00000515279; ENSP00000422354; ENSG00000138780. [Q8NEC7-1]
GeneIDi79807.
KEGGihsa:79807.
UCSCiuc003hxy.4. human. [Q8NEC7-1]

Organism-specific databases

CTDi79807.
GeneCardsiGSTCD.
H-InvDBHIX0004423.
HGNCiHGNC:25806. GSTCD.
HPAiHPA046160.
HPA061782.
MIMi615912. gene.
neXtProtiNX_Q8NEC7.
PharmGKBiPA144596427.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDXE. Eukaryota.
ENOG410ZVJE. LUCA.
GeneTreeiENSGT00390000004446.
HOGENOMiHOG000038504.
HOVERGENiHBG107970.
InParanoidiQ8NEC7.
OMAiPRNRIYT.
OrthoDBiEOG091G098R.
PhylomeDBiQ8NEC7.
TreeFamiTF324238.

Miscellaneous databases

GenomeRNAii79807.
PROiQ8NEC7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138780.
CleanExiHS_GSTCD.
ExpressionAtlasiQ8NEC7. baseline and differential.
GenevisibleiQ8NEC7. HS.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.50.150. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR025714. Methyltranfer_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF13679. Methyltransf_32. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTCD_HUMAN
AccessioniPrimary (citable) accession number: Q8NEC7
Secondary accession number(s): A8K8J0
, A8MVD3, H9KV97, Q9H8S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.