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Q8NEB9

- PK3C3_HUMAN

UniProt

Q8NEB9 - PK3C3_HUMAN

Protein

Phosphatidylinositol 3-kinase catalytic subunit type 3

Gene

PIK3C3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.3 Publications

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

    Cofactori

    Manganese.1 Publication

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB
    2. ATP binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB
    4. protein kinase activity Source: Ensembl

    GO - Biological processi

    1. autophagic vacuole assembly Source: Ensembl
    2. cytokinesis Source: UniProtKB
    3. early endosome to late endosome transport Source: UniProtKB
    4. endosome organization Source: Ensembl
    5. innate immune response Source: Reactome
    6. insulin receptor signaling pathway Source: Reactome
    7. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
    8. phosphatidylinositol biosynthetic process Source: Reactome
    9. phosphatidylinositol-mediated signaling Source: Ensembl
    10. phospholipid metabolic process Source: Reactome
    11. protein processing Source: Ensembl
    12. regulation of protein secretion Source: Ensembl
    13. response to leucine Source: Ensembl
    14. small molecule metabolic process Source: Reactome
    15. toll-like receptor 9 signaling pathway Source: Reactome
    16. toll-like receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Autophagy, Cell cycle, Cell division

    Keywords - Ligandi

    ATP-binding, Manganese, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:HS01275-MONOMER.
    ReactomeiREACT_120756. Synthesis of PIPs at the early endosome membrane.
    REACT_120836. Synthesis of PIPs at the Golgi membrane.
    REACT_120918. Synthesis of PIPs at the late endosome membrane.
    REACT_9047. Toll Like Receptor 9 (TLR9) Cascade.
    REACT_976. PI3K Cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC:2.7.1.137)
    Short name:
    PI3-kinase type 3
    Short name:
    PI3K type 3
    Short name:
    PtdIns-3-kinase type 3
    Alternative name(s):
    Phosphatidylinositol 3-kinase p100 subunit
    Phosphoinositide-3-kinase class 3
    hVps34
    Gene namesi
    Name:PIK3C3
    Synonyms:VPS34
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:8974. PIK3C3.

    Subcellular locationi

    Midbody. Late endosome
    Note: Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.By similarity

    GO - Cellular componenti

    1. axoneme Source: UniProtKB
    2. cytosol Source: Reactome
    3. late endosome Source: UniProtKB
    4. membrane Source: UniProtKB
    5. midbody Source: UniProtKB
    6. phosphatidylinositol 3-kinase complex Source: RefGenome

    Keywords - Cellular componenti

    Endosome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33307.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 887887Phosphatidylinositol 3-kinase catalytic subunit type 3PRO_0000088802Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei261 – 2611Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8NEB9.
    PaxDbiQ8NEB9.
    PeptideAtlasiQ8NEB9.
    PRIDEiQ8NEB9.

    PTM databases

    PhosphoSiteiQ8NEB9.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed, with a highest expression in skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ8NEB9.
    BgeeiQ8NEB9.
    CleanExiHS_PIK3C3.
    GenevestigatoriQ8NEB9.

    Organism-specific databases

    HPAiHPA040718.

    Interactioni

    Subunit structurei

    Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. Forms a complex with BECN1, PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive. Part of a complex composed of PIK3R4 and PIK3CB By similarity. Interacts with RAB7A in the presence of PIK3R4. Interacts with BECN1P1/BECN2.By similarity5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BECN1Q1445714EBI-1056470,EBI-949378

    Protein-protein interaction databases

    BioGridi111307. 28 interactions.
    DIPiDIP-42272N.
    IntActiQ8NEB9. 12 interactions.
    MINTiMINT-1682773.
    STRINGi9606.ENSP00000262039.

    Structurei

    Secondary structure

    1
    887
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi283 – 2853
    Helixi290 – 30112
    Helixi310 – 3189
    Helixi320 – 3234
    Helixi327 – 3293
    Helixi330 – 3345
    Helixi342 – 35413
    Helixi360 – 3634
    Helixi364 – 3674
    Helixi374 – 38411
    Helixi389 – 3946
    Helixi396 – 4027
    Helixi403 – 4053
    Helixi408 – 4136
    Helixi442 – 4443
    Helixi475 – 48410
    Helixi487 – 50216
    Helixi504 – 5096
    Helixi511 – 53020
    Helixi533 – 56129
    Helixi566 – 57813
    Helixi580 – 5834
    Beta strandi589 – 5935
    Beta strandi596 – 6049
    Helixi606 – 6083
    Beta strandi619 – 6257
    Beta strandi630 – 63910
    Helixi642 – 66019
    Beta strandi672 – 68312
    Helixi690 – 6967
    Helixi700 – 7078
    Helixi714 – 7163
    Helixi719 – 73921
    Beta strandi748 – 7514
    Beta strandi757 – 7593
    Beta strandi770 – 7734
    Helixi781 – 7866
    Helixi793 – 81119
    Helixi813 – 8219
    Turni822 – 8254
    Helixi829 – 8324
    Helixi835 – 8373
    Helixi838 – 8458
    Turni846 – 8494
    Helixi852 – 87019

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3IHYX-ray2.80A/B/C/D/E282-879[»]
    3LS8X-ray2.25A/B268-879[»]
    ProteinModelPortaliQ8NEB9.
    SMRiQ8NEB9. Positions 57-147, 230-871.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8NEB9.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 184150C2 PI3K-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini283 – 520238PIK helicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini631 – 885255PI3K/PI4KPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
    Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
    Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
    Contains 1 PIK helical domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5032.
    HOGENOMiHOG000174003.
    HOVERGENiHBG082145.
    KOiK00914.
    OMAiYLMVEFP.
    OrthoDBiEOG7PP55Z.
    PhylomeDBiQ8NEB9.
    TreeFamiTF102032.

    Family and domain databases

    Gene3Di1.10.1070.11. 1 hit.
    1.25.40.70. 2 hits.
    2.60.40.150. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR002420. PI3K_C2_dom.
    IPR008290. PI3K_Vps34.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    [Graphical view]
    PANTHERiPTHR10048. PTHR10048. 1 hit.
    PfamiPF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000587. PI3K_Vps34. 1 hit.
    SMARTiSM00239. C2. 1 hit.
    SM00142. PI3K_C2. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    SSF49562. SSF49562. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NEB9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEAEKFHYI YSCDLDINVQ LKIGSLEGKR EQKSYKAVLE DPMLKFSGLY    50
    QETCSDLYVT CQVFAEGKPL ALPVRTSYKA FSTRWNWNEW LKLPVKYPDL 100
    PRNAQVALTI WDVYGPGKAV PVGGTTVSLF GKYGMFRQGM HDLKVWPNVE 150
    ADGSEPTKTP GRTSSTLSED QMSRLAKLTK AHRQGHMVKV DWLDRLTFRE 200
    IEMINESEKR SSNFMYLMVE FRCVKCDDKE YGIVYYEKDG DESSPILTSF 250
    ELVKVPDPQM SMENLVESKH HKLARSLRSG PSDHDLKPNA ATRDQLNIIV 300
    SYPPTKQLTY EEQDLVWKFR YYLTNQEKAL TKFLKCVNWD LPQEAKQALE 350
    LLGKWKPMDV EDSLELLSSH YTNPTVRRYA VARLRQADDE DLLMYLLQLV 400
    QALKYENFDD IKNGLEPTKK DSQSSVSENV SNSGINSAEI DSSQIITSPL 450
    PSVSSPPPAS KTKEVPDGEN LEQDLCTFLI SRACKNSTLA NYLYWYVIVE 500
    CEDQDTQQRD PKTHEMYLNV MRRFSQALLK GDKSVRVMRS LLAAQQTFVD 550
    RLVHLMKAVQ RESGNRKKKN ERLQALLGDN EKMNLSDVEL IPLPLEPQVK 600
    IRGIIPETAT LFKSALMPAQ LFFKTEDGGK YPVIFKHGDD LRQDQLILQI 650
    ISLMDKLLRK ENLDLKLTPY KVLATSTKHG FMQFIQSVPV AEVLDTEGSI 700
    QNFFRKYAPS ENGPNGISAE VMDTYVKSCA GYCVITYILG VGDRHLDNLL 750
    LTKTGKLFHI DFGYILGRDP KPLPPPMKLN KEMVEGMGGT QSEQYQEFRK 800
    QCYTAFLHLR RYSNLILNLF SLMVDANIPD IALEPDKTVK KVQDKFRLDL 850
    SDEEAVHYMQ SLIDESVHAL FAAVVEQIHK FAQYWRK 887
    Length:887
    Mass (Da):101,549
    Last modified:October 1, 2002 - v1
    Checksum:i1C03D97338E44976
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti36 – 361K → N in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti70 – 701L → S in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti136 – 1361F → S in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti158 – 1581K → N in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti208 – 2081E → V in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti219 – 2202VE → GG in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti262 – 2621M → L in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti272 – 2743KLA → NLP in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti289 – 2924NAAT → YPSP in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti297 – 2982NI → KN in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti305 – 3084TKQL → SKPP in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti318 – 3181K → E in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti327 – 3271E → D in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti333 – 3386FLKCVN → ILTSVI in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti344 – 3441E → G in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti350 – 3501E → A in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti356 – 3561K → N in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti367 – 3671L → I in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti397 – 3971L → S in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti428 – 4281E → G in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti484 – 4841C → S in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti750 – 7501L → V in CAA87094. (PubMed:7628435)Curated
    Sequence conflicti826 – 8261A → P in CAA87094. (PubMed:7628435)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46973 mRNA. Translation: CAA87094.1.
    BC033004 mRNA. Translation: AAH33004.1.
    BC053651 mRNA. Translation: AAH53651.1.
    CCDSiCCDS11920.1.
    PIRiS57219.
    RefSeqiNP_002638.2. NM_002647.2.
    UniGeneiHs.464971.

    Genome annotation databases

    EnsembliENST00000262039; ENSP00000262039; ENSG00000078142.
    GeneIDi5289.
    KEGGihsa:5289.
    UCSCiuc002lap.3. human.

    Polymorphism databases

    DMDMi74730233.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46973 mRNA. Translation: CAA87094.1 .
    BC033004 mRNA. Translation: AAH33004.1 .
    BC053651 mRNA. Translation: AAH53651.1 .
    CCDSi CCDS11920.1.
    PIRi S57219.
    RefSeqi NP_002638.2. NM_002647.2.
    UniGenei Hs.464971.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3IHY X-ray 2.80 A/B/C/D/E 282-879 [» ]
    3LS8 X-ray 2.25 A/B 268-879 [» ]
    ProteinModelPortali Q8NEB9.
    SMRi Q8NEB9. Positions 57-147, 230-871.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111307. 28 interactions.
    DIPi DIP-42272N.
    IntActi Q8NEB9. 12 interactions.
    MINTi MINT-1682773.
    STRINGi 9606.ENSP00000262039.

    Chemistry

    BindingDBi Q8NEB9.
    ChEMBLi CHEMBL1075165.

    PTM databases

    PhosphoSitei Q8NEB9.

    Polymorphism databases

    DMDMi 74730233.

    Proteomic databases

    MaxQBi Q8NEB9.
    PaxDbi Q8NEB9.
    PeptideAtlasi Q8NEB9.
    PRIDEi Q8NEB9.

    Protocols and materials databases

    DNASUi 5289.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262039 ; ENSP00000262039 ; ENSG00000078142 .
    GeneIDi 5289.
    KEGGi hsa:5289.
    UCSCi uc002lap.3. human.

    Organism-specific databases

    CTDi 5289.
    GeneCardsi GC18P039535.
    HGNCi HGNC:8974. PIK3C3.
    HPAi HPA040718.
    MIMi 602609. gene.
    neXtProti NX_Q8NEB9.
    PharmGKBi PA33307.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5032.
    HOGENOMi HOG000174003.
    HOVERGENi HBG082145.
    KOi K00914.
    OMAi YLMVEFP.
    OrthoDBi EOG7PP55Z.
    PhylomeDBi Q8NEB9.
    TreeFami TF102032.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS01275-MONOMER.
    Reactomei REACT_120756. Synthesis of PIPs at the early endosome membrane.
    REACT_120836. Synthesis of PIPs at the Golgi membrane.
    REACT_120918. Synthesis of PIPs at the late endosome membrane.
    REACT_9047. Toll Like Receptor 9 (TLR9) Cascade.
    REACT_976. PI3K Cascade.

    Miscellaneous databases

    ChiTaRSi PIK3C3. human.
    EvolutionaryTracei Q8NEB9.
    GeneWikii PIK3C3.
    GenomeRNAii 5289.
    NextBioi 20438.
    PROi Q8NEB9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NEB9.
    Bgeei Q8NEB9.
    CleanExi HS_PIK3C3.
    Genevestigatori Q8NEB9.

    Family and domain databases

    Gene3Di 1.10.1070.11. 1 hit.
    1.25.40.70. 2 hits.
    2.60.40.150. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR002420. PI3K_C2_dom.
    IPR008290. PI3K_Vps34.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    [Graphical view ]
    PANTHERi PTHR10048. PTHR10048. 1 hit.
    Pfami PF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF00613. PI3Ka. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000587. PI3K_Vps34. 1 hit.
    SMARTi SM00239. C2. 1 hit.
    SM00142. PI3K_C2. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    SSF49562. SSF49562. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system."
      Volinia S., Dhand R., Vanhaesebroeck B., MacDougall L.K., Zvelebil M.J., Domin J., Panaretou C., Waterfield M.D.
      EMBO J. 14:3339-3348(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, COFACTOR, SUBUNIT, TISSUE SPECIFICITY, INTERACTION WITH PIK3R4.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis and Uterus.
    3. "Human VPS34 and p150 are Rab7 interacting partners."
      Stein M.P., Feng Y., Cooper K.L., Welford A.M., Wandinger-Ness A.
      Traffic 4:754-771(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH RAB7A AND PIK3R4, SUBCELLULAR LOCATION.
    4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase."
      Sun Q., Fan W., Chen K., Ding X., Chen S., Zhong Q.
      Proc. Natl. Acad. Sci. U.S.A. 105:19211-19216(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BECN1 AND ATG14.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages."
      Matsunaga K., Saitoh T., Tabata K., Omori H., Satoh T., Kurotori N., Maejima I., Shirahama-Noda K., Ichimura T., Isobe T., Akira S., Noda T., Yoshimori T.
      Nat. Cell Biol. 11:385-396(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BECN1; KIAA0226; ATG14; PIK3R4 AND UVRAG.
    8. "PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody."
      Sagona A.P., Nezis I.P., Pedersen N.M., Liestol K., Poulton J., Rusten T.E., Skotheim R.I., Raiborg C., Stenmark H.
      Nat. Cell Biol. 12:362-371(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism."
      He C., Wei Y., Sun K., Li B., Dong X., Zou Z., Liu Y., Kinch L.N., Khan S., Sinha S., Xavier R.J., Grishin N.V., Xiao G., Eskelinen E.L., Scherer P.E., Whistler J.L., Levine B.
      Cell 154:1085-1099(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BECN1P1/BECN2.

    Entry informationi

    Entry nameiPK3C3_HUMAN
    AccessioniPrimary (citable) accession number: Q8NEB9
    Secondary accession number(s): Q15134
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3