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Q8NEB7 (ACRBP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acrosin-binding protein
Alternative name(s):
Cancer/testis antigen 23
Short name=CT23
Cancer/testis antigen OY-TES-1
Proacrosin-binding protein sp32
Gene names
Name:ACRBP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length543 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin By similarity.

Subunit structure

Binds proacrosin By similarity. UniProtKB Q29016

Subcellular location

Secreted By similarity. Cytoplasmic vesiclesecretory vesicleacrosome By similarity. Note: Colocalizes with proacrosin in the acrosome of sperm By similarity.

Tissue specificity

Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers, including bladder, breast, liver, lung and colon cancers. Ref.1

Post-translational modification

The N-terminus is blocked By similarity.

Phosphorylated on Tyr residues in capacitated sperm By similarity.

Ontologies

Keywords
   Cellular componentCytoplasmic vesicle
Secreted
   Coding sequence diversityPolymorphism
   DomainSignal
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentacrosomal vesicle

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 543518Acrosin-binding protein
PRO_0000227516

Natural variations

Natural variant3361T → A.
Corresponds to variant rs3741923 [ dbSNP | Ensembl ].
VAR_050633

Experimental info

Sequence conflict321S → P in BAB39388. Ref.1
Sequence conflict3161L → F in BAB39388. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8NEB7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 44D0F23583522DD9

FASTA54361,359
        10         20         30         40         50         60 
MRKPAAGFLP SLLKVLLLPL APAAAQDSTQ ASTPGSPLSP TEYERFFALL TPTWKAETTC 

        70         80         90        100        110        120 
RLRATHGCRN PTLVQLDQYE NHGLVPDGAV CSNLPYASWF ESFCQFTHYR CSNHVYYAKR 

       130        140        150        160        170        180 
VLCSQPVSIL SPNTLKEIEA SAEVSPTTMT SPISPHFTVT ERQTFQPWPE RLSNNVEELL 

       190        200        210        220        230        240 
QSSLSLGGQE QAPEHKQEQG VEHRQEPTQE HKQEEGQKQE EQEEEQEEEG KQEEGQGTKE 

       250        260        270        280        290        300 
GREAVSQLQT DSEPKFHSES LSSNPSSFAP RVREVESTPM IMENIQELIR SAQEIDEMNE 

       310        320        330        340        350        360 
IYDENSYWRN QNPGSLLQLP HTEALLVLCY SIVENTCIIT PTAKAWKYME EEILGFGKSV 

       370        380        390        400        410        420 
CDSLGRRHMS TCALCDFCSL KLEQCHSEAS LQRQQCDTSH KTPFVSPLLA SQSLSIGNQV 

       430        440        450        460        470        480 
GSPESGRFYG LDLYGGLHMD FWCARLATKG CEDVRVSGWL QTEFLSFQDG DFPTKICDTD 

       490        500        510        520        530        540 
YIQYPNYCSF KSQQCLMRNR NRKVSRMRCL QNETYSALSP GKSEDVVLRW SQEFSTLTLG 


QFG 

« Hide

References

« Hide 'large scale' references
[1]"Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen."
Ono T., Kurashige T., Harada N., Noguchi Y., Saika T., Niikawa N., Aoe M., Nakamura S., Higashi T., Hiraki A., Wada H., Kumon H., Old L.J., Nakayama E.
Proc. Natl. Acad. Sci. U.S.A. 98:3282-3287(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB051833 mRNA. Translation: BAB39388.1.
BC033010 mRNA. Translation: AAH33010.1.
RefSeqNP_115878.2. NM_032489.2.
UniGeneHs.123239.

3D structure databases

ProteinModelPortalQ8NEB7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124113. 1 interaction.
STRING9606.ENSP00000229243.

PTM databases

PhosphoSiteQ8NEB7.

Polymorphism databases

DMDM74730232.

Proteomic databases

PaxDbQ8NEB7.
PRIDEQ8NEB7.

Protocols and materials databases

DNASU84519.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000229243; ENSP00000229243; ENSG00000111644.
GeneID84519.
KEGGhsa:84519.
UCSCuc001qpu.1. human.

Organism-specific databases

CTD84519.
GeneCardsGC12M006748.
HGNCHGNC:17195. ACRBP.
HPAHPA039081.
HPA039082.
MIM608352. gene.
neXtProtNX_Q8NEB7.
PharmGKBPA24452.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45475.
HOGENOMHOG000033789.
HOVERGENHBG080819.
InParanoidQ8NEB7.
OMAEQCHSEA.
OrthoDBEOG7DZ8JQ.
PhylomeDBQ8NEB7.
TreeFamTF336597.

Gene expression databases

ArrayExpressQ8NEB7.
BgeeQ8NEB7.
CleanExHS_ACRBP.
GenevestigatorQ8NEB7.

Family and domain databases

InterProIPR002350. Kazal_dom.
IPR009865. Proacrosin-bd.
[Graphical view]
PANTHERPTHR21362. PTHR21362. 1 hit.
PfamPF07222. PBP_sp32. 1 hit.
[Graphical view]
SMARTSM00280. KAZAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSACRBP. human.
GenomeRNAi84519.
NextBio74335.
PROQ8NEB7.
SOURCESearch...

Entry information

Entry nameACRBP_HUMAN
AccessionPrimary (citable) accession number: Q8NEB7
Secondary accession number(s): Q9BY87
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM