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Q8NEB7

- ACRBP_HUMAN

UniProt

Q8NEB7 - ACRBP_HUMAN

Protein

Acrosin-binding protein

Gene

ACRBP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acrosin-binding protein
    Alternative name(s):
    Cancer/testis antigen 23
    Short name:
    CT23
    Cancer/testis antigen OY-TES-1
    Proacrosin-binding protein sp32
    Gene namesi
    Name:ACRBPImported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:17195. ACRBP.

    Subcellular locationi

    Secreted By similarity. Cytoplasmic vesiclesecretory vesicleacrosome By similarity
    Note: Colocalizes with proacrosin in the acrosome of sperm.By similarity

    GO - Cellular componenti

    1. acrosomal vesicle Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-SubCell
    3. nucleus Source: UniProt

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24452.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 543518Acrosin-binding proteinPRO_0000227516Add
    BLAST

    Post-translational modificationi

    The N-terminus is blocked.By similarity
    Phosphorylated on Tyr residues in capacitated sperm.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8NEB7.
    PRIDEiQ8NEB7.

    PTM databases

    PhosphoSiteiQ8NEB7.

    Expressioni

    Tissue specificityi

    Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers, including bladder, breast, liver, lung and colon cancers.1 Publication

    Gene expression databases

    ArrayExpressiQ8NEB7.
    BgeeiQ8NEB7.
    CleanExiHS_ACRBP.
    GenevestigatoriQ8NEB7.

    Organism-specific databases

    HPAiHPA039081.
    HPA039082.

    Interactioni

    Subunit structurei

    Binds proacrosin.By similarity

    Protein-protein interaction databases

    BioGridi124113. 1 interaction.
    STRINGi9606.ENSP00000229243.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NEB7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45475.
    HOGENOMiHOG000033789.
    HOVERGENiHBG080819.
    InParanoidiQ8NEB7.
    OMAiEQCHSEA.
    OrthoDBiEOG7DZ8JQ.
    PhylomeDBiQ8NEB7.
    TreeFamiTF336597.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    IPR009865. Proacrosin-bd.
    [Graphical view]
    PANTHERiPTHR21362. PTHR21362. 1 hit.
    PfamiPF07222. PBP_sp32. 1 hit.
    [Graphical view]
    SMARTiSM00280. KAZAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8NEB7-1 [UniParc]FASTAAdd to Basket

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    MRKPAAGFLP SLLKVLLLPL APAAAQDSTQ ASTPGSPLSP TEYERFFALL    50
    TPTWKAETTC RLRATHGCRN PTLVQLDQYE NHGLVPDGAV CSNLPYASWF 100
    ESFCQFTHYR CSNHVYYAKR VLCSQPVSIL SPNTLKEIEA SAEVSPTTMT 150
    SPISPHFTVT ERQTFQPWPE RLSNNVEELL QSSLSLGGQE QAPEHKQEQG 200
    VEHRQEPTQE HKQEEGQKQE EQEEEQEEEG KQEEGQGTKE GREAVSQLQT 250
    DSEPKFHSES LSSNPSSFAP RVREVESTPM IMENIQELIR SAQEIDEMNE 300
    IYDENSYWRN QNPGSLLQLP HTEALLVLCY SIVENTCIIT PTAKAWKYME 350
    EEILGFGKSV CDSLGRRHMS TCALCDFCSL KLEQCHSEAS LQRQQCDTSH 400
    KTPFVSPLLA SQSLSIGNQV GSPESGRFYG LDLYGGLHMD FWCARLATKG 450
    CEDVRVSGWL QTEFLSFQDG DFPTKICDTD YIQYPNYCSF KSQQCLMRNR 500
    NRKVSRMRCL QNETYSALSP GKSEDVVLRW SQEFSTLTLG QFG 543
    Length:543
    Mass (Da):61,359
    Last modified:October 1, 2002 - v1
    Checksum:i44D0F23583522DD9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321S → P in BAB39388. (PubMed:11248070)Curated
    Sequence conflicti316 – 3161L → F in BAB39388. (PubMed:11248070)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti336 – 3361T → A.
    Corresponds to variant rs3741923 [ dbSNP | Ensembl ].
    VAR_050633

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051833 mRNA. Translation: BAB39388.1.
    BC033010 mRNA. Translation: AAH33010.1.
    CCDSiCCDS8554.1.
    RefSeqiNP_115878.2. NM_032489.2.
    UniGeneiHs.123239.

    Genome annotation databases

    EnsembliENST00000229243; ENSP00000229243; ENSG00000111644.
    GeneIDi84519.
    KEGGihsa:84519.
    UCSCiuc001qpu.1. human.

    Polymorphism databases

    DMDMi74730232.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051833 mRNA. Translation: BAB39388.1 .
    BC033010 mRNA. Translation: AAH33010.1 .
    CCDSi CCDS8554.1.
    RefSeqi NP_115878.2. NM_032489.2.
    UniGenei Hs.123239.

    3D structure databases

    ProteinModelPortali Q8NEB7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124113. 1 interaction.
    STRINGi 9606.ENSP00000229243.

    PTM databases

    PhosphoSitei Q8NEB7.

    Polymorphism databases

    DMDMi 74730232.

    Proteomic databases

    PaxDbi Q8NEB7.
    PRIDEi Q8NEB7.

    Protocols and materials databases

    DNASUi 84519.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000229243 ; ENSP00000229243 ; ENSG00000111644 .
    GeneIDi 84519.
    KEGGi hsa:84519.
    UCSCi uc001qpu.1. human.

    Organism-specific databases

    CTDi 84519.
    GeneCardsi GC12M006748.
    HGNCi HGNC:17195. ACRBP.
    HPAi HPA039081.
    HPA039082.
    MIMi 608352. gene.
    neXtProti NX_Q8NEB7.
    PharmGKBi PA24452.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45475.
    HOGENOMi HOG000033789.
    HOVERGENi HBG080819.
    InParanoidi Q8NEB7.
    OMAi EQCHSEA.
    OrthoDBi EOG7DZ8JQ.
    PhylomeDBi Q8NEB7.
    TreeFami TF336597.

    Miscellaneous databases

    ChiTaRSi ACRBP. human.
    GenomeRNAii 84519.
    NextBioi 74335.
    PROi Q8NEB7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NEB7.
    Bgeei Q8NEB7.
    CleanExi HS_ACRBP.
    Genevestigatori Q8NEB7.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    IPR009865. Proacrosin-bd.
    [Graphical view ]
    PANTHERi PTHR21362. PTHR21362. 1 hit.
    Pfami PF07222. PBP_sp32. 1 hit.
    [Graphical view ]
    SMARTi SM00280. KAZAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: TestisImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: TestisImported.

    Entry informationi

    Entry nameiACRBP_HUMAN
    AccessioniPrimary (citable) accession number: Q8NEB7
    Secondary accession number(s): Q9BY87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3