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Q8NEB7

- ACRBP_HUMAN

UniProt

Q8NEB7 - ACRBP_HUMAN

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Protein

Acrosin-binding protein

Gene

ACRBP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Acrosin-binding protein
Alternative name(s):
Cancer/testis antigen 23
Short name:
CT23
Cancer/testis antigen OY-TES-1
Proacrosin-binding protein sp32
Gene namesi
Name:ACRBPImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:17195. ACRBP.

Subcellular locationi

Secreted By similarity. Cytoplasmic vesiclesecretory vesicleacrosome By similarity
Note: Colocalizes with proacrosin in the acrosome of sperm.By similarity

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
  3. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24452.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 543518Acrosin-binding proteinPRO_0000227516Add
BLAST

Post-translational modificationi

The N-terminus is blocked.By similarity
Phosphorylated on Tyr residues in capacitated sperm.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8NEB7.
PRIDEiQ8NEB7.

PTM databases

PhosphoSiteiQ8NEB7.

Expressioni

Tissue specificityi

Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers, including bladder, breast, liver, lung and colon cancers.1 Publication

Gene expression databases

BgeeiQ8NEB7.
CleanExiHS_ACRBP.
ExpressionAtlasiQ8NEB7. baseline and differential.
GenevestigatoriQ8NEB7.

Organism-specific databases

HPAiHPA039081.
HPA039082.

Interactioni

Subunit structurei

Binds proacrosin.By similarity

Protein-protein interaction databases

BioGridi124113. 1 interaction.
STRINGi9606.ENSP00000229243.

Structurei

3D structure databases

ProteinModelPortaliQ8NEB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45475.
GeneTreeiENSGT00390000000826.
HOGENOMiHOG000033789.
HOVERGENiHBG080819.
InParanoidiQ8NEB7.
OMAiEQCHSEA.
OrthoDBiEOG7DZ8JQ.
PhylomeDBiQ8NEB7.
TreeFamiTF336597.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR009865. Proacrosin-bd.
[Graphical view]
PANTHERiPTHR21362. PTHR21362. 1 hit.
PfamiPF07222. PBP_sp32. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NEB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKPAAGFLP SLLKVLLLPL APAAAQDSTQ ASTPGSPLSP TEYERFFALL
60 70 80 90 100
TPTWKAETTC RLRATHGCRN PTLVQLDQYE NHGLVPDGAV CSNLPYASWF
110 120 130 140 150
ESFCQFTHYR CSNHVYYAKR VLCSQPVSIL SPNTLKEIEA SAEVSPTTMT
160 170 180 190 200
SPISPHFTVT ERQTFQPWPE RLSNNVEELL QSSLSLGGQE QAPEHKQEQG
210 220 230 240 250
VEHRQEPTQE HKQEEGQKQE EQEEEQEEEG KQEEGQGTKE GREAVSQLQT
260 270 280 290 300
DSEPKFHSES LSSNPSSFAP RVREVESTPM IMENIQELIR SAQEIDEMNE
310 320 330 340 350
IYDENSYWRN QNPGSLLQLP HTEALLVLCY SIVENTCIIT PTAKAWKYME
360 370 380 390 400
EEILGFGKSV CDSLGRRHMS TCALCDFCSL KLEQCHSEAS LQRQQCDTSH
410 420 430 440 450
KTPFVSPLLA SQSLSIGNQV GSPESGRFYG LDLYGGLHMD FWCARLATKG
460 470 480 490 500
CEDVRVSGWL QTEFLSFQDG DFPTKICDTD YIQYPNYCSF KSQQCLMRNR
510 520 530 540
NRKVSRMRCL QNETYSALSP GKSEDVVLRW SQEFSTLTLG QFG
Length:543
Mass (Da):61,359
Last modified:October 1, 2002 - v1
Checksum:i44D0F23583522DD9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321S → P in BAB39388. (PubMed:11248070)Curated
Sequence conflicti316 – 3161L → F in BAB39388. (PubMed:11248070)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti336 – 3361T → A.
Corresponds to variant rs3741923 [ dbSNP | Ensembl ].
VAR_050633

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB051833 mRNA. Translation: BAB39388.1.
BC033010 mRNA. Translation: AAH33010.1.
CCDSiCCDS8554.1.
RefSeqiNP_115878.2. NM_032489.2.
UniGeneiHs.123239.

Genome annotation databases

EnsembliENST00000229243; ENSP00000229243; ENSG00000111644.
GeneIDi84519.
KEGGihsa:84519.
UCSCiuc001qpu.1. human.

Polymorphism databases

DMDMi74730232.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB051833 mRNA. Translation: BAB39388.1 .
BC033010 mRNA. Translation: AAH33010.1 .
CCDSi CCDS8554.1.
RefSeqi NP_115878.2. NM_032489.2.
UniGenei Hs.123239.

3D structure databases

ProteinModelPortali Q8NEB7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124113. 1 interaction.
STRINGi 9606.ENSP00000229243.

PTM databases

PhosphoSitei Q8NEB7.

Polymorphism databases

DMDMi 74730232.

Proteomic databases

PaxDbi Q8NEB7.
PRIDEi Q8NEB7.

Protocols and materials databases

DNASUi 84519.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000229243 ; ENSP00000229243 ; ENSG00000111644 .
GeneIDi 84519.
KEGGi hsa:84519.
UCSCi uc001qpu.1. human.

Organism-specific databases

CTDi 84519.
GeneCardsi GC12M006748.
HGNCi HGNC:17195. ACRBP.
HPAi HPA039081.
HPA039082.
MIMi 608352. gene.
neXtProti NX_Q8NEB7.
PharmGKBi PA24452.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45475.
GeneTreei ENSGT00390000000826.
HOGENOMi HOG000033789.
HOVERGENi HBG080819.
InParanoidi Q8NEB7.
OMAi EQCHSEA.
OrthoDBi EOG7DZ8JQ.
PhylomeDBi Q8NEB7.
TreeFami TF336597.

Miscellaneous databases

ChiTaRSi ACRBP. human.
GenomeRNAii 84519.
NextBioi 74335.
PROi Q8NEB7.
SOURCEi Search...

Gene expression databases

Bgeei Q8NEB7.
CleanExi HS_ACRBP.
ExpressionAtlasi Q8NEB7. baseline and differential.
Genevestigatori Q8NEB7.

Family and domain databases

InterProi IPR002350. Kazal_dom.
IPR009865. Proacrosin-bd.
[Graphical view ]
PANTHERi PTHR21362. PTHR21362. 1 hit.
Pfami PF07222. PBP_sp32. 1 hit.
[Graphical view ]
SMARTi SM00280. KAZAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: TestisImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestisImported.

Entry informationi

Entry nameiACRBP_HUMAN
AccessioniPrimary (citable) accession number: Q8NEB7
Secondary accession number(s): Q9BY87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3