Reviewed,
UniProtKB/Swiss-Prot Q8NEB7 (ACRBP_HUMAN)
Last modified
June 16, 2009.
Version 50.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Acrosin-binding protein Alternative name(s): Proacrosin-binding protein sp32 Cancer/testis antigen OY-TES-1 Cancer/testis antigen 23 Short name=CT23 | ||
| Gene names |
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| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 543 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin By similarity. |
| Subunit structure | Binds proacrosin By similarity. UniProtKB Q29016 |
| Subcellular location | Secreted By similarity. Acrosome By similarity. Note: Colocalizes with proacrosin in the acrosome of sperm By similarity. |
| Tissue specificity | Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers, including bladder, breast, liver, lung and colon cancers. Ref.1 |
| Post-translational modification | The N-terminus is blocked By similarity. Phosphorylated on Tyr residues in capacitated sperm By similarity. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Polymorphism |
| Domain | Signal |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Cellular component | acrosomal vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular regionInferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 25 | 25 | Potential | ||||||
| Chain | 26 – 543 | 518 | Acrosin-binding protein | PRO_0000227516 | |||||
Natural variations | |||||||||
| Natural variant | 336 | 1 | T → A: dbSNP rs3741923. | VAR_050633 | |||||
Experimental info | |||||||||
| Sequence conflict | 32 | 1 | S → P in BAB39388. Ref.1 | ||||||
| Sequence conflict | 316 | 1 | L → F in BAB39388. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen." Ono T., Kurashige T., Harada N., Noguchi Y., Saika T., Niikawa N., Aoe M., Nakamura S., Higashi T., Hiraki A., Wada H., Kumon H., Old L.J., Nakayama E. Proc. Natl. Acad. Sci. U.S.A. 98:3282-3287(2001) [PubMed: 11248070] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Testis. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AB051833 mRNA. Translation: BAB39388.1. BC033010 mRNA. Translation: AAH33010.1. | |
| IPI | IPI00168645. |
| RefSeq | NP_115878.2. |
| UniGene | Hs.123239 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q8NEB7. |
Genome annotation databases | |
| Ensembl | ENSG00000111644. Homo sapiens. [Contig view] |
| GeneID | 84519. |
| KEGG | hsa:84519. |
Organism-specific databases | |
| GeneCards | GC12M006617. |
| H-InvDB | HIX0010373. |
| HGNC | HGNC:17195. ACRBP. |
| MIM | 608352. gene. |
| PharmGKB | PA24452. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q8NEB7. |
| HOVERGEN | Q8NEB7. |
| OMA | Q8NEB7. LEQCHSE. |
Gene expression databases | |
| ArrayExpress | Q8NEB7. |
| Bgee | Q8NEB7. |
| CleanEx | HS_ACRBP. |
| GermOnline | ENSG00000111644. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR009865. Proacrosin_bd. IPR002350. Prot_inh_Kazal. [Graphical view] |
| PANTHER | PTHR21362. Proacrosin_bd. 1 hit. |
| Pfam | PF07222. PBP_sp32. 1 hit. [Graphical view] |
| SMART | SM00280. KAZAL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 74335. |
| SOURCE | Search... |
Entry information
| Entry name | ACRBP_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8NEB7 Secondary accession number(s): Q9BY87 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |

Clusters with


