Reviewed, UniProtKB/Swiss-Prot Q8NEB7 (ACRBP_HUMAN)

Names and origin

Protein names

Recommended name:
    Acrosin-binding protein
Alternative name(s):
    Proacrosin-binding protein sp32
    Cancer/testis antigen OY-TES-1
    Cancer/testis antigen 23
      Short name=CT23

Gene names

Name:

ACRBP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	543 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin By similarity.
Subunit structure	Binds proacrosin By similarity. UniProtKB Q29016
Subcellular location	Secreted By similarity. Acrosome By similarity. Note: Colocalizes with proacrosin in the acrosome of sperm By similarity.
Tissue specificity	Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers, including bladder, breast, liver, lung and colon cancers. Ref.1
Post-translational modification	The N-terminus is blocked By similarity. Phosphorylated on Tyr residues in capacitated sperm By similarity.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	acrosomal vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 543	518	Acrosin-binding protein		PRO_0000227516
Natural variations
	Natural variant	336	1	T → A: dbSNP rs3741923.		VAR_050633
Experimental info
	Sequence conflict	32	1	S → P in BAB39388. Ref.1
	Sequence conflict	316	1	L → F in BAB39388. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8NEB7-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 44D0F23583522DD9	FASTA	543	61,359
	10 20 30 40 50 60 MRKPAAGFLP SLLKVLLLPL APAAAQDSTQ ASTPGSPLSP TEYERFFALL TPTWKAETTC 70 80 90 100 110 120 RLRATHGCRN PTLVQLDQYE NHGLVPDGAV CSNLPYASWF ESFCQFTHYR CSNHVYYAKR 130 140 150 160 170 180 VLCSQPVSIL SPNTLKEIEA SAEVSPTTMT SPISPHFTVT ERQTFQPWPE RLSNNVEELL 190 200 210 220 230 240 QSSLSLGGQE QAPEHKQEQG VEHRQEPTQE HKQEEGQKQE EQEEEQEEEG KQEEGQGTKE 250 260 270 280 290 300 GREAVSQLQT DSEPKFHSES LSSNPSSFAP RVREVESTPM IMENIQELIR SAQEIDEMNE 310 320 330 340 350 360 IYDENSYWRN QNPGSLLQLP HTEALLVLCY SIVENTCIIT PTAKAWKYME EEILGFGKSV 370 380 390 400 410 420 CDSLGRRHMS TCALCDFCSL KLEQCHSEAS LQRQQCDTSH KTPFVSPLLA SQSLSIGNQV 430 440 450 460 470 480 GSPESGRFYG LDLYGGLHMD FWCARLATKG CEDVRVSGWL QTEFLSFQDG DFPTKICDTD 490 500 510 520 530 540 YIQYPNYCSF KSQQCLMRNR NRKVSRMRCL QNETYSALSP GKSEDVVLRW SQEFSTLTLG QFG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen." Ono T., Kurashige T., Harada N., Noguchi Y., Saika T., Niikawa N., Aoe M., Nakamura S., Higashi T., Hiraki A., Wada H., Kumon H., Old L.J., Nakayama E. Proc. Natl. Acad. Sci. U.S.A. 98:3282-3287(2001) [PubMed: 11248070] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB051833 mRNA. Translation: BAB39388.1. BC033010 mRNA. Translation: AAH33010.1.
IPI	IPI00168645.
RefSeq	NP_115878.2.
UniGene	Hs.123239
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q8NEB7.
Genome annotation databases
Ensembl	ENSG00000111644. Homo sapiens. [Contig view]
GeneID	84519.
KEGG	hsa:84519.
Organism-specific databases
GeneCards	GC12M006617.
H-InvDB	HIX0010373.
HGNC	HGNC:17195. ACRBP.
MIM	608352. gene.
PharmGKB	PA24452.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8NEB7.
HOVERGEN	Q8NEB7.
OMA	Q8NEB7. LEQCHSE.
Gene expression databases
ArrayExpress	Q8NEB7.
Bgee	Q8NEB7.
CleanEx	HS_ACRBP.
GermOnline	ENSG00000111644. Homo sapiens.
Family and domain databases
InterPro	IPR009865. Proacrosin_bd. IPR002350. Prot_inh_Kazal. [Graphical view]
PANTHER	PTHR21362. Proacrosin_bd. 1 hit.
Pfam	PF07222. PBP_sp32. 1 hit. [Graphical view]
SMART	SM00280. KAZAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	74335.
SOURCE	Search...

Entry information

Entry name

ACRBP_HUMAN

Accession

Primary (citable) accession number: Q8NEB7
Secondary accession number(s): Q9BY87

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)