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Q8NEA9

- GMCLL_HUMAN

UniProt

Q8NEA9 - GMCLL_HUMAN

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Protein
Putative germ cell-less protein-like 1-like
Gene
GMCL1P1, GCL, GMCL1L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport By similarity. Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.1 Publication

Pathwayi

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. protein ubiquitination Source: UniProtKB-UniPathway
  4. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative germ cell-less protein-like 1-like
Gene namesi
Name:GMCL1P1
Synonyms:GCL, GMCL1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:19717. GMCL1P1.

Subcellular locationi

Nucleus matrix By similarity

GO - Cellular componenti

  1. nuclear matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Putative germ cell-less protein-like 1-like
PRO_0000087523Add
BLAST

Proteomic databases

PRIDEiQ8NEA9.

PTM databases

PhosphoSiteiQ8NEA9.

Expressioni

Gene expression databases

CleanExiHS_GMCL1L.
GenevestigatoriQ8NEA9.

Organism-specific databases

HPAiHPA039579.

Interactioni

Subunit structurei

Interacts with TMPO-Beta, TSG101 and TFDP2. Interacts with EMD By similarity. Interacts with CUL3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GAGE2DQ9UEU52EBI-745707,EBI-751641

Protein-protein interaction databases

IntActiQ8NEA9. 2 interactions.
MINTiMINT-1453252.

Structurei

3D structure databases

ProteinModelPortaliQ8NEA9.
SMRiQ8NEA9. Positions 95-283.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 17871BTB
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi49 – 557Nuclear localization signal Reviewed prediction
Motifi85 – 917Nuclear localization signal Reviewed prediction

Sequence similaritiesi

Contains 1 BTB (POZ) domain.

Phylogenomic databases

HOGENOMiHOG000232133.
HOVERGENiHBG051741.
InParanoidiQ8NEA9.
PhylomeDBiQ8NEA9.

Family and domain databases

Gene3Di3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NEA9-1 [UniParc]FASTAAdd to Basket

« Hide

MGSSSSRVLG QPRRALAQQE QGARARGSAR RPDTGDDAAS YGFCYCPGSH    50
KRKRSSGACR YCDPDSHREE HEEEGDKQQP LLNTPARKKL RSTSKYIYQT 100
LFLNGENSDI KICALGEEWR LHKIYLCQSG YFSSMFSGSW KESSMNIIEL 150
EIPDQNIDVD ALQVAFGSLY RDDVLIKPSR VVAILAAACM LQLDGLIQQC 200
GETMKETINV KTVCGYYTSV EIYGLDSVKK KCLEWLLNNL MTHQNVKLFK 250
ELGINVMKQL IGSSNLFVMQ VEMDVYTTLK KWMFLQLVPS WNGSLKQLLT 300
ETDVWFSKQR KDFEGMAFLE TEPGKPFVSV FRHLRLQYII SDLASARIIE 350
QDGIVPSEWL SSVYKQQWFA MLRAEQDHEV GPQEINKEDL EGSSMRCGRK 400
LAKDGEYYWC WTGFNFGFDL LVIYTNGYII FKRNTLNQPC SGSVSLRPRR 450
SIAFRLRLAS FDSSGKLVCS RTTGYQILIL KKDQEQVVMN LDSRFLTFPL 500
YICCNFLYIS PEKGIENNRH PEDPEN 526
Length:526
Mass (Da):60,201
Last modified:October 1, 2002 - v1
Checksum:iA5583195143E4782
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti275 – 2751V → A in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035924

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471P → Q in BC024184. 1 Publication
Sequence conflicti230 – 2301K → E in BC024184. 1 Publication
Sequence conflicti230 – 2301K → E in BC024185. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK315701 mRNA. Translation: BAG38063.1.
BC024184 mRNA. No translation available.
BC024185 mRNA. No translation available.
BC033886 mRNA. No translation available.
UniGeneiHs.591738.

Polymorphism databases

DMDMi47605713.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK315701 mRNA. Translation: BAG38063.1 .
BC024184 mRNA. No translation available.
BC024185 mRNA. No translation available.
BC033886 mRNA. No translation available.
UniGenei Hs.591738.

3D structure databases

ProteinModelPortali Q8NEA9.
SMRi Q8NEA9. Positions 95-283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8NEA9. 2 interactions.
MINTi MINT-1453252.

PTM databases

PhosphoSitei Q8NEA9.

Polymorphism databases

DMDMi 47605713.

Proteomic databases

PRIDEi Q8NEA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC05M177611.
H-InvDB HIX0005475.
HGNCi HGNC:19717. GMCL1P1.
HPAi HPA039579.
neXtProti NX_Q8NEA9.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000232133.
HOVERGENi HBG051741.
InParanoidi Q8NEA9.
PhylomeDBi Q8NEA9.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

PROi Q8NEA9.

Gene expression databases

CleanExi HS_GMCL1L.
Genevestigatori Q8NEA9.

Family and domain databases

Gene3Di 3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."
    Furukawa M., He Y.J., Borchers C., Xiong Y.
    Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] ALA-275.

Entry informationi

Entry nameiGMCLL_HUMAN
AccessioniPrimary (citable) accession number: Q8NEA9
Secondary accession number(s): B2RDW6, Q8TC88, Q8TC89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2002
Last modified: June 11, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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