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Protein

Putative germ cell-less protein-like 1-like

Gene

GMCL1P1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity1 Publication

Pathway:iprotein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative germ cell-less protein-like 1-like
Gene namesi
Name:GMCL1P1
Synonyms:GCL, GMCL1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:19717. GMCL1P1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi47605713.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Putative germ cell-less protein-like 1-likePRO_0000087523Add
BLAST

Proteomic databases

PRIDEiQ8NEA9.

PTM databases

PhosphoSiteiQ8NEA9.

Expressioni

Gene expression databases

CleanExiHS_GMCL1L.

Organism-specific databases

HPAiHPA039579.

Interactioni

Subunit structurei

Interacts with TMPO-Beta, TSG101 and TFDP2. Interacts with EMD (By similarity). Interacts with CUL3.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-745707,EBI-10173507
BCL11AQ9H165-23EBI-745707,EBI-10183342
BHLHE40O145033EBI-745707,EBI-711810
CHCHD3Q9NX633EBI-745707,EBI-743375
FLJ13057Q53SE73EBI-745707,EBI-10172181
GAGE12EA1L4293EBI-745707,EBI-10172187
GAGE12IP0CL823EBI-745707,EBI-10196803
GAGE5Q130694EBI-745707,EBI-745702
GAGE8Q9UEU55EBI-745707,EBI-751641
HNRNPMP522723EBI-745707,EBI-486809
IKZF1Q134223EBI-745707,EBI-745305
KAT5Q929933EBI-745707,EBI-399080
LIMS3LP0CW203EBI-745707,EBI-10196832
LZTS2Q9BRK43EBI-745707,EBI-741037
MEOX2A4D1273EBI-745707,EBI-10172134
SHQ1Q6PI263EBI-745707,EBI-2515568
TRAF1Q130773EBI-745707,EBI-359224
TRIM23P364063EBI-745707,EBI-740098
UBE2IQ7KZS03EBI-745707,EBI-10180829
USHBP1Q8N6Y03EBI-745707,EBI-739895
XAGE2BQ96GT93EBI-745707,EBI-750167

Protein-protein interaction databases

IntActiQ8NEA9. 21 interactions.
MINTiMINT-1453252.

Structurei

3D structure databases

ProteinModelPortaliQ8NEA9.
SMRiQ8NEA9. Positions 100-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 17871BTBPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi49 – 557Nuclear localization signalSequence Analysis
Motifi85 – 917Nuclear localization signalSequence Analysis

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000232133.
HOVERGENiHBG051741.
InParanoidiQ8NEA9.
PhylomeDBiQ8NEA9.

Family and domain databases

InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NEA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSSSRVLG QPRRALAQQE QGARARGSAR RPDTGDDAAS YGFCYCPGSH
60 70 80 90 100
KRKRSSGACR YCDPDSHREE HEEEGDKQQP LLNTPARKKL RSTSKYIYQT
110 120 130 140 150
LFLNGENSDI KICALGEEWR LHKIYLCQSG YFSSMFSGSW KESSMNIIEL
160 170 180 190 200
EIPDQNIDVD ALQVAFGSLY RDDVLIKPSR VVAILAAACM LQLDGLIQQC
210 220 230 240 250
GETMKETINV KTVCGYYTSV EIYGLDSVKK KCLEWLLNNL MTHQNVKLFK
260 270 280 290 300
ELGINVMKQL IGSSNLFVMQ VEMDVYTTLK KWMFLQLVPS WNGSLKQLLT
310 320 330 340 350
ETDVWFSKQR KDFEGMAFLE TEPGKPFVSV FRHLRLQYII SDLASARIIE
360 370 380 390 400
QDGIVPSEWL SSVYKQQWFA MLRAEQDHEV GPQEINKEDL EGSSMRCGRK
410 420 430 440 450
LAKDGEYYWC WTGFNFGFDL LVIYTNGYII FKRNTLNQPC SGSVSLRPRR
460 470 480 490 500
SIAFRLRLAS FDSSGKLVCS RTTGYQILIL KKDQEQVVMN LDSRFLTFPL
510 520
YICCNFLYIS PEKGIENNRH PEDPEN
Length:526
Mass (Da):60,201
Last modified:October 1, 2002 - v1
Checksum:iA5583195143E4782
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471P → Q in BC024184 (PubMed:15489334).Curated
Sequence conflicti230 – 2301K → E in BC024184 (PubMed:15489334).Curated
Sequence conflicti230 – 2301K → E in BC024185 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti275 – 2751V → A in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035924

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315701 mRNA. Translation: BAG38063.1.
BC024184 mRNA. No translation available.
BC024185 mRNA. No translation available.
BC033886 mRNA. No translation available.
UniGeneiHs.591738.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315701 mRNA. Translation: BAG38063.1.
BC024184 mRNA. No translation available.
BC024185 mRNA. No translation available.
BC033886 mRNA. No translation available.
UniGeneiHs.591738.

3D structure databases

ProteinModelPortaliQ8NEA9.
SMRiQ8NEA9. Positions 100-205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8NEA9. 21 interactions.
MINTiMINT-1453252.

PTM databases

PhosphoSiteiQ8NEA9.

Polymorphism and mutation databases

DMDMi47605713.

Proteomic databases

PRIDEiQ8NEA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiGC05M177611.
H-InvDBHIX0005475.
HGNCiHGNC:19717. GMCL1P1.
HPAiHPA039579.
neXtProtiNX_Q8NEA9.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000232133.
HOVERGENiHBG051741.
InParanoidiQ8NEA9.
PhylomeDBiQ8NEA9.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ8NEA9.

Gene expression databases

CleanExiHS_GMCL1L.

Family and domain databases

InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."
    Furukawa M., He Y.J., Borchers C., Xiong Y.
    Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] ALA-275.

Entry informationi

Entry nameiGMCLL_HUMAN
AccessioniPrimary (citable) accession number: Q8NEA9
Secondary accession number(s): B2RDW6, Q8TC88, Q8TC89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.