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Q8NEA9

- GMCLL_HUMAN

UniProt

Q8NEA9 - GMCLL_HUMAN

Protein

Putative germ cell-less protein-like 1-like

Gene

GMCL1P1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport By similarity. Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity1 Publication

    Pathwayi

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. protein ubiquitination Source: UniProtKB-UniPathway
    4. spermatogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis, Ubl conjugation pathway

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative germ cell-less protein-like 1-like
    Gene namesi
    Name:GMCL1P1
    Synonyms:GCL, GMCL1L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:19717. GMCL1P1.

    Subcellular locationi

    Nucleus matrix By similarity

    GO - Cellular componenti

    1. nuclear matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 526526Putative germ cell-less protein-like 1-likePRO_0000087523Add
    BLAST

    Proteomic databases

    PRIDEiQ8NEA9.

    PTM databases

    PhosphoSiteiQ8NEA9.

    Expressioni

    Gene expression databases

    CleanExiHS_GMCL1L.
    GenevestigatoriQ8NEA9.

    Organism-specific databases

    HPAiHPA039579.

    Interactioni

    Subunit structurei

    Interacts with TMPO-Beta, TSG101 and TFDP2. Interacts with EMD By similarity. Interacts with CUL3.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GAGE2DQ9UEU52EBI-745707,EBI-751641

    Protein-protein interaction databases

    IntActiQ8NEA9. 2 interactions.
    MINTiMINT-1453252.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NEA9.
    SMRiQ8NEA9. Positions 95-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini108 – 17871BTBPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi49 – 557Nuclear localization signalSequence Analysis
    Motifi85 – 917Nuclear localization signalSequence Analysis

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000232133.
    HOVERGENiHBG051741.
    InParanoidiQ8NEA9.
    PhylomeDBiQ8NEA9.

    Family and domain databases

    Gene3Di3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NEA9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSSSSRVLG QPRRALAQQE QGARARGSAR RPDTGDDAAS YGFCYCPGSH    50
    KRKRSSGACR YCDPDSHREE HEEEGDKQQP LLNTPARKKL RSTSKYIYQT 100
    LFLNGENSDI KICALGEEWR LHKIYLCQSG YFSSMFSGSW KESSMNIIEL 150
    EIPDQNIDVD ALQVAFGSLY RDDVLIKPSR VVAILAAACM LQLDGLIQQC 200
    GETMKETINV KTVCGYYTSV EIYGLDSVKK KCLEWLLNNL MTHQNVKLFK 250
    ELGINVMKQL IGSSNLFVMQ VEMDVYTTLK KWMFLQLVPS WNGSLKQLLT 300
    ETDVWFSKQR KDFEGMAFLE TEPGKPFVSV FRHLRLQYII SDLASARIIE 350
    QDGIVPSEWL SSVYKQQWFA MLRAEQDHEV GPQEINKEDL EGSSMRCGRK 400
    LAKDGEYYWC WTGFNFGFDL LVIYTNGYII FKRNTLNQPC SGSVSLRPRR 450
    SIAFRLRLAS FDSSGKLVCS RTTGYQILIL KKDQEQVVMN LDSRFLTFPL 500
    YICCNFLYIS PEKGIENNRH PEDPEN 526
    Length:526
    Mass (Da):60,201
    Last modified:October 1, 2002 - v1
    Checksum:iA5583195143E4782
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti47 – 471P → Q in BC024184. (PubMed:15489334)Curated
    Sequence conflicti230 – 2301K → E in BC024184. (PubMed:15489334)Curated
    Sequence conflicti230 – 2301K → E in BC024185. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti275 – 2751V → A in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035924

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK315701 mRNA. Translation: BAG38063.1.
    BC024184 mRNA. No translation available.
    BC024185 mRNA. No translation available.
    BC033886 mRNA. No translation available.
    UniGeneiHs.591738.

    Polymorphism databases

    DMDMi47605713.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK315701 mRNA. Translation: BAG38063.1 .
    BC024184 mRNA. No translation available.
    BC024185 mRNA. No translation available.
    BC033886 mRNA. No translation available.
    UniGenei Hs.591738.

    3D structure databases

    ProteinModelPortali Q8NEA9.
    SMRi Q8NEA9. Positions 95-283.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8NEA9. 2 interactions.
    MINTi MINT-1453252.

    PTM databases

    PhosphoSitei Q8NEA9.

    Polymorphism databases

    DMDMi 47605713.

    Proteomic databases

    PRIDEi Q8NEA9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC05M177611.
    H-InvDB HIX0005475.
    HGNCi HGNC:19717. GMCL1P1.
    HPAi HPA039579.
    neXtProti NX_Q8NEA9.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000232133.
    HOVERGENi HBG051741.
    InParanoidi Q8NEA9.
    PhylomeDBi Q8NEA9.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    PROi Q8NEA9.

    Gene expression databases

    CleanExi HS_GMCL1L.
    Genevestigatori Q8NEA9.

    Family and domain databases

    Gene3Di 3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."
      Furukawa M., He Y.J., Borchers C., Xiong Y.
      Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.
    4. Cited for: VARIANT [LARGE SCALE ANALYSIS] ALA-275.

    Entry informationi

    Entry nameiGMCLL_HUMAN
    AccessioniPrimary (citable) accession number: Q8NEA9
    Secondary accession number(s): B2RDW6, Q8TC88, Q8TC89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3