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Protein

Protein ZNF738

Gene

ZNF738

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172684-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ZNF738
Gene namesi
Name:ZNF738
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:32469. ZNF738.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172687.

Polymorphism and mutation databases

DMDMi74730211.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002748791 – 137Protein ZNF738Add BLAST137

Proteomic databases

EPDiQ8NE65.
PaxDbiQ8NE65.
PeptideAtlasiQ8NE65.
PRIDEiQ8NE65.

PTM databases

iPTMnetiQ8NE65.
PhosphoSitePlusiQ8NE65.

Expressioni

Gene expression databases

BgeeiENSG00000172687.
CleanExiHS_ZNF738.
ExpressionAtlasiQ8NE65. baseline and differential.
GenevisibleiQ8NE65. HS.

Organism-specific databases

HPAiHPA059135.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311957.

Structurei

3D structure databases

ProteinModelPortaliQ8NE65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 106KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 1 KRAB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132355.
HOGENOMiHOG000231475.
HOVERGENiHBG067759.
InParanoidiQ8NE65.
OMAiQSVNICF.
OrthoDBiEOG091G0RKV.
PhylomeDBiQ8NE65.
TreeFamiTF342644.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiIPR001909. KRAB.
IPR026613. KRAB_dom_C2H2_Znf_fam.
[Graphical view]
PANTHERiPTHR23232. PTHR23232. 1 hit.
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NE65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDLRYGVYP VKGASGYPGA ERNLLEYSYF EKGPLTFRDV VIEFSQEEWQ
60 70 80 90 100
CLDTAQQDLY RKVMLENFRN LVFLGIDVSK PDLITCLEQG KDPWNMKRHS
110 120 130
MVATPPESGV LKFPTIIILL SRCFFQSVNI CFIYLEP
Length:137
Mass (Da):15,884
Last modified:October 1, 2002 - v1
Checksum:i799B9BE0A3B61C43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291002 mRNA. Translation: BAF83691.1.
AK291193 mRNA. Translation: BAF83882.1.
AC010615 Genomic DNA. No translation available.
AC022432 Genomic DNA. No translation available.
BC034499 mRNA. No translation available.
UniGeneiHs.124384.

Genome annotation databases

EnsembliENST00000311015; ENSP00000311957; ENSG00000172687.
UCSCiuc002nps.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291002 mRNA. Translation: BAF83691.1.
AK291193 mRNA. Translation: BAF83882.1.
AC010615 Genomic DNA. No translation available.
AC022432 Genomic DNA. No translation available.
BC034499 mRNA. No translation available.
UniGeneiHs.124384.

3D structure databases

ProteinModelPortaliQ8NE65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000311957.

PTM databases

iPTMnetiQ8NE65.
PhosphoSitePlusiQ8NE65.

Polymorphism and mutation databases

DMDMi74730211.

Proteomic databases

EPDiQ8NE65.
PaxDbiQ8NE65.
PeptideAtlasiQ8NE65.
PRIDEiQ8NE65.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311015; ENSP00000311957; ENSG00000172687.
UCSCiuc002nps.5. human.

Organism-specific databases

GeneCardsiZNF738.
HGNCiHGNC:32469. ZNF738.
HPAiHPA059135.
neXtProtiNX_Q8NE65.
OpenTargetsiENSG00000172687.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132355.
HOGENOMiHOG000231475.
HOVERGENiHBG067759.
InParanoidiQ8NE65.
OMAiQSVNICF.
OrthoDBiEOG091G0RKV.
PhylomeDBiQ8NE65.
TreeFamiTF342644.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172684-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF738. human.
PROiQ8NE65.

Gene expression databases

BgeeiENSG00000172687.
CleanExiHS_ZNF738.
ExpressionAtlasiQ8NE65. baseline and differential.
GenevisibleiQ8NE65. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiIPR001909. KRAB.
IPR026613. KRAB_dom_C2H2_Znf_fam.
[Graphical view]
PANTHERiPTHR23232. PTHR23232. 1 hit.
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN738_HUMAN
AccessioniPrimary (citable) accession number: Q8NE65
Secondary accession number(s): A8K4N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite its name, it does not contain a canonical C2H2-type zinc-finger.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.