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Q8NE63 (HIPK4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeodomain-interacting protein kinase 4

EC=2.7.11.1
Gene names
Name:HIPK4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length616 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter By similarity. May act as a corepressor of transcription factors Potential.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cytoplasm By similarity.

Post-translational modification

Autophosphorylated By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence BAB71458.1 differs from that shown. Reason: Aberrant splicing.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 616616Homeodomain-interacting protein kinase 4
PRO_0000232401

Regions

Domain11 – 347337Protein kinase
Nucleotide binding17 – 259ATP By similarity

Sites

Active site1361Proton acceptor By similarity
Binding site401ATP By similarity

Natural variations

Natural variant1061A → T. Ref.3
Corresponds to variant rs34434715 [ dbSNP | Ensembl ].
VAR_040554
Natural variant1711V → M. Ref.3
Corresponds to variant rs55964225 [ dbSNP | Ensembl ].
VAR_040555
Natural variant3021R → Q.
Corresponds to variant rs11670988 [ dbSNP | Ensembl ].
VAR_030578
Natural variant3811T → M. Ref.3
Corresponds to variant rs55760165 [ dbSNP | Ensembl ].
VAR_040556
Natural variant3861A → T. Ref.3
Corresponds to variant rs56365273 [ dbSNP | Ensembl ].
VAR_040557
Natural variant4061S → R. Ref.3
Corresponds to variant rs56094851 [ dbSNP | Ensembl ].
VAR_040558
Natural variant4211G → S. Ref.3
Corresponds to variant rs56117722 [ dbSNP | Ensembl ].
VAR_040559
Natural variant4811R → C. Ref.3
Corresponds to variant rs55801979 [ dbSNP | Ensembl ].
VAR_040560

Experimental info

Sequence conflict3741Q → R in BAB71458. Ref.1
Sequence conflict4451T → A in BAB71458. Ref.1
Sequence conflict5811E → G in BAF84917. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8NE63 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 02429E8F2070C6C0

FASTA61669,425
        10         20         30         40         50         60 
MSTIQSETDC YDIIEVLGKG TFGEVAKGWR RSTGEMVAIK ILKNDAYRNR IIKNELKLLH 

        70         80         90        100        110        120 
CMRGLDPEEA HVIRFLEFFH DALKFYLVFE LLEQNLFEFQ KENNFAPLPA RHIRTVTLQV 

       130        140        150        160        170        180 
LTALARLKEL AIIHADLKPE NIMLVDQTRC PFRVKVIDFG SASIFSEVRY VKEPYIQSRF 

       190        200        210        220        230        240 
YRAPEILLGL PFCEKVDVWS LGCVMAELHL GWPLYPGNNE YDQVRYICET QGLPKPHLLH 

       250        260        270        280        290        300 
AACKAHHFFK RNPHPDAANP WQLKSSADYL AETKVRPLER RKYMLKSLDQ IETVNGGSVA 

       310        320        330        340        350        360 
SRLTFPDREA LAEHADLKSM VELIKRMLTW ESHERISPSA ALRHPFVSMQ QLRSAHETTH 

       370        380        390        400        410        420 
YYQLSLRSYR LSLQVEGKPP TPVVAAEDGT PYYCLAEEKE AAGMGSVAGS SPFFREEKAP 

       430        440        450        460        470        480 
GMQRAIDQLD DLSLQEAGHG LWGETCTNAV SDMMVPLKAA ITGHHVPDSG PEPILAFYSS 

       490        500        510        520        530        540 
RLAGRHKARK PPAGSKSDSN FSNLIRLSQV SPEDDRPCRG SSWEEGEHLG ASAEPLAILQ 

       550        560        570        580        590        600 
RDEDGPNIDN MTMEAERPDP ELFDPSSCPG EWLSEPDCTL ESVRGPRAQG LPPRRSHQHG 

       610 
PPRGATSFLQ HVTGHH 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-106; MET-171; MET-381; THR-386; ARG-406; SER-421 AND CYS-481.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK057380 mRNA. Translation: BAB71458.1. Sequence problems.
AK292228 mRNA. Translation: BAF84917.1.
BC034501 mRNA. Translation: AAH34501.1.
RefSeqNP_653286.2. NM_144685.3.
UniGeneHs.79363.

3D structure databases

ProteinModelPortalQ8NE63.
SMRQ8NE63. Positions 9-346.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127086. 29 interactions.
IntActQ8NE63. 24 interactions.
STRING9606.ENSP00000291823.

Chemistry

BindingDBQ8NE63.
ChEMBLCHEMBL1075167.
GuidetoPHARMACOLOGY2036.

PTM databases

PhosphoSiteQ8NE63.

Polymorphism databases

DMDM74762559.

Proteomic databases

PaxDbQ8NE63.
PRIDEQ8NE63.

Protocols and materials databases

DNASU147746.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000291823; ENSP00000291823; ENSG00000160396.
GeneID147746.
KEGGhsa:147746.
UCSCuc002onp.3. human.

Organism-specific databases

CTD147746.
GeneCardsGC19M040885.
HGNCHGNC:19007. HIPK4.
HPAHPA027733.
MIM611712. gene.
neXtProtNX_Q8NE63.
PharmGKBPA134883524.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000090252.
HOVERGENHBG081604.
InParanoidQ8NE63.
KOK08826.
OMAFREEKAP.
OrthoDBEOG7034GK.
PhylomeDBQ8NE63.
TreeFamTF105417.

Enzyme and pathway databases

SignaLinkQ8NE63.

Gene expression databases

ArrayExpressQ8NE63.
BgeeQ8NE63.
CleanExHS_HIPK4.
GenevestigatorQ8NE63.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi147746.
NextBio85724.
PROQ8NE63.
SOURCESearch...

Entry information

Entry nameHIPK4_HUMAN
AccessionPrimary (citable) accession number: Q8NE63
Secondary accession number(s): A8K863, Q96M54
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2002
Last modified: March 19, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM