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Protein

Homeodomain-interacting protein kinase 4

Gene

HIPK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential).By similarityCurated

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40ATPPROSITE-ProRule annotation1
Active sitei136Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 25ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8NE63

Names & Taxonomyi

Protein namesi
Recommended name:
Homeodomain-interacting protein kinase 4 (EC:2.7.11.1)
Gene namesi
Name:HIPK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000160396.8
HGNCiHGNC:19007 HIPK4
MIMi611712 gene
neXtProtiNX_Q8NE63

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160396
PharmGKBiPA134883524

Chemistry databases

ChEMBLiCHEMBL1075167
GuidetoPHARMACOLOGYi2036

Polymorphism and mutation databases

BioMutaiHIPK4
DMDMi74762559

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002324011 – 616Homeodomain-interacting protein kinase 4Add BLAST616

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei511PhosphoserineBy similarity1

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8NE63
PeptideAtlasiQ8NE63
PRIDEiQ8NE63

PTM databases

iPTMnetiQ8NE63
PhosphoSitePlusiQ8NE63

Expressioni

Gene expression databases

BgeeiENSG00000160396
CleanExiHS_HIPK4
ExpressionAtlasiQ8NE63 baseline and differential
GenevisibleiQ8NE63 HS

Organism-specific databases

HPAiHPA027733

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-6381114,EBI-743771

Protein-protein interaction databases

BioGridi127086, 29 interactors
IntActiQ8NE63, 25 interactors
STRINGi9606.ENSP00000291823

Chemistry databases

BindingDBiQ8NE63

Structurei

3D structure databases

ProteinModelPortaliQ8NE63
SMRiQ8NE63
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 347Protein kinasePROSITE-ProRule annotationAdd BLAST337

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0667 Eukaryota
ENOG410XPET LUCA
GeneTreeiENSGT00760000119032
HOGENOMiHOG000090252
HOVERGENiHBG081604
InParanoidiQ8NE63
KOiK08826
OMAiGPPYYRL
OrthoDBiEOG091G04Y2
PhylomeDBiQ8NE63
TreeFamiTF105417

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NE63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTIQSETDC YDIIEVLGKG TFGEVAKGWR RSTGEMVAIK ILKNDAYRNR
60 70 80 90 100
IIKNELKLLH CMRGLDPEEA HVIRFLEFFH DALKFYLVFE LLEQNLFEFQ
110 120 130 140 150
KENNFAPLPA RHIRTVTLQV LTALARLKEL AIIHADLKPE NIMLVDQTRC
160 170 180 190 200
PFRVKVIDFG SASIFSEVRY VKEPYIQSRF YRAPEILLGL PFCEKVDVWS
210 220 230 240 250
LGCVMAELHL GWPLYPGNNE YDQVRYICET QGLPKPHLLH AACKAHHFFK
260 270 280 290 300
RNPHPDAANP WQLKSSADYL AETKVRPLER RKYMLKSLDQ IETVNGGSVA
310 320 330 340 350
SRLTFPDREA LAEHADLKSM VELIKRMLTW ESHERISPSA ALRHPFVSMQ
360 370 380 390 400
QLRSAHETTH YYQLSLRSYR LSLQVEGKPP TPVVAAEDGT PYYCLAEEKE
410 420 430 440 450
AAGMGSVAGS SPFFREEKAP GMQRAIDQLD DLSLQEAGHG LWGETCTNAV
460 470 480 490 500
SDMMVPLKAA ITGHHVPDSG PEPILAFYSS RLAGRHKARK PPAGSKSDSN
510 520 530 540 550
FSNLIRLSQV SPEDDRPCRG SSWEEGEHLG ASAEPLAILQ RDEDGPNIDN
560 570 580 590 600
MTMEAERPDP ELFDPSSCPG EWLSEPDCTL ESVRGPRAQG LPPRRSHQHG
610
PPRGATSFLQ HVTGHH
Length:616
Mass (Da):69,425
Last modified:October 1, 2002 - v1
Checksum:i02429E8F2070C6C0
GO

Sequence cautioni

The sequence BAB71458 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti374Q → R in BAB71458 (PubMed:14702039).Curated1
Sequence conflicti445T → A in BAB71458 (PubMed:14702039).Curated1
Sequence conflicti581E → G in BAF84917 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040554106A → T1 PublicationCorresponds to variant dbSNP:rs34434715Ensembl.1
Natural variantiVAR_040555171V → M1 PublicationCorresponds to variant dbSNP:rs55964225Ensembl.1
Natural variantiVAR_030578302R → Q. Corresponds to variant dbSNP:rs11670988Ensembl.1
Natural variantiVAR_040556381T → M1 PublicationCorresponds to variant dbSNP:rs55760165Ensembl.1
Natural variantiVAR_040557386A → T1 PublicationCorresponds to variant dbSNP:rs56365273Ensembl.1
Natural variantiVAR_040558406S → R1 PublicationCorresponds to variant dbSNP:rs56094851Ensembl.1
Natural variantiVAR_040559421G → S1 PublicationCorresponds to variant dbSNP:rs56117722Ensembl.1
Natural variantiVAR_040560481R → C1 PublicationCorresponds to variant dbSNP:rs55801979Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057380 mRNA Translation: BAB71458.1 Sequence problems.
AK292228 mRNA Translation: BAF84917.1
BC034501 mRNA Translation: AAH34501.1
CCDSiCCDS12555.1
RefSeqiNP_653286.2, NM_144685.4
UniGeneiHs.79363

Genome annotation databases

EnsembliENST00000291823; ENSP00000291823; ENSG00000160396
GeneIDi147746
KEGGihsa:147746
UCSCiuc002onp.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHIPK4_HUMAN
AccessioniPrimary (citable) accession number: Q8NE63
Secondary accession number(s): A8K863, Q96M54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health