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Q8NE63

- HIPK4_HUMAN

UniProt

Q8NE63 - HIPK4_HUMAN

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Protein
Homeodomain-interacting protein kinase 4
Gene
HIPK4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter By similarity. May act as a corepressor of transcription factors Reviewed prediction.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401ATP By similarity
Active sitei136 – 1361Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 259ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ8NE63.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeodomain-interacting protein kinase 4 (EC:2.7.11.1)
    Gene namesi
    Name:HIPK4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:19007. HIPK4.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134883524.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 616616Homeodomain-interacting protein kinase 4
    PRO_0000232401Add
    BLAST

    Post-translational modificationi

    Autophosphorylated By similarity.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8NE63.
    PRIDEiQ8NE63.

    PTM databases

    PhosphoSiteiQ8NE63.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NE63.
    BgeeiQ8NE63.
    CleanExiHS_HIPK4.
    GenevestigatoriQ8NE63.

    Organism-specific databases

    HPAiHPA027733.

    Interactioni

    Protein-protein interaction databases

    BioGridi127086. 29 interactions.
    IntActiQ8NE63. 24 interactions.
    STRINGi9606.ENSP00000291823.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NE63.
    SMRiQ8NE63. Positions 9-371.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 347337Protein kinase
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000090252.
    HOVERGENiHBG081604.
    InParanoidiQ8NE63.
    KOiK08826.
    OMAiFREEKAP.
    OrthoDBiEOG7034GK.
    PhylomeDBiQ8NE63.
    TreeFamiTF105417.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NE63-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTIQSETDC YDIIEVLGKG TFGEVAKGWR RSTGEMVAIK ILKNDAYRNR    50
    IIKNELKLLH CMRGLDPEEA HVIRFLEFFH DALKFYLVFE LLEQNLFEFQ 100
    KENNFAPLPA RHIRTVTLQV LTALARLKEL AIIHADLKPE NIMLVDQTRC 150
    PFRVKVIDFG SASIFSEVRY VKEPYIQSRF YRAPEILLGL PFCEKVDVWS 200
    LGCVMAELHL GWPLYPGNNE YDQVRYICET QGLPKPHLLH AACKAHHFFK 250
    RNPHPDAANP WQLKSSADYL AETKVRPLER RKYMLKSLDQ IETVNGGSVA 300
    SRLTFPDREA LAEHADLKSM VELIKRMLTW ESHERISPSA ALRHPFVSMQ 350
    QLRSAHETTH YYQLSLRSYR LSLQVEGKPP TPVVAAEDGT PYYCLAEEKE 400
    AAGMGSVAGS SPFFREEKAP GMQRAIDQLD DLSLQEAGHG LWGETCTNAV 450
    SDMMVPLKAA ITGHHVPDSG PEPILAFYSS RLAGRHKARK PPAGSKSDSN 500
    FSNLIRLSQV SPEDDRPCRG SSWEEGEHLG ASAEPLAILQ RDEDGPNIDN 550
    MTMEAERPDP ELFDPSSCPG EWLSEPDCTL ESVRGPRAQG LPPRRSHQHG 600
    PPRGATSFLQ HVTGHH 616
    Length:616
    Mass (Da):69,425
    Last modified:October 1, 2002 - v1
    Checksum:i02429E8F2070C6C0
    GO

    Sequence cautioni

    The sequence BAB71458.1 differs from that shown. Reason: Aberrant splicing.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti106 – 1061A → T.1 Publication
    Corresponds to variant rs34434715 [ dbSNP | Ensembl ].
    VAR_040554
    Natural varianti171 – 1711V → M.1 Publication
    Corresponds to variant rs55964225 [ dbSNP | Ensembl ].
    VAR_040555
    Natural varianti302 – 3021R → Q.
    Corresponds to variant rs11670988 [ dbSNP | Ensembl ].
    VAR_030578
    Natural varianti381 – 3811T → M.1 Publication
    Corresponds to variant rs55760165 [ dbSNP | Ensembl ].
    VAR_040556
    Natural varianti386 – 3861A → T.1 Publication
    Corresponds to variant rs56365273 [ dbSNP | Ensembl ].
    VAR_040557
    Natural varianti406 – 4061S → R.1 Publication
    Corresponds to variant rs56094851 [ dbSNP | Ensembl ].
    VAR_040558
    Natural varianti421 – 4211G → S.1 Publication
    Corresponds to variant rs56117722 [ dbSNP | Ensembl ].
    VAR_040559
    Natural varianti481 – 4811R → C.1 Publication
    Corresponds to variant rs55801979 [ dbSNP | Ensembl ].
    VAR_040560

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti374 – 3741Q → R in BAB71458. 1 Publication
    Sequence conflicti445 – 4451T → A in BAB71458. 1 Publication
    Sequence conflicti581 – 5811E → G in BAF84917. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057380 mRNA. Translation: BAB71458.1. Sequence problems.
    AK292228 mRNA. Translation: BAF84917.1.
    BC034501 mRNA. Translation: AAH34501.1.
    CCDSiCCDS12555.1.
    RefSeqiNP_653286.2. NM_144685.3.
    UniGeneiHs.79363.

    Genome annotation databases

    EnsembliENST00000291823; ENSP00000291823; ENSG00000160396.
    GeneIDi147746.
    KEGGihsa:147746.
    UCSCiuc002onp.3. human.

    Polymorphism databases

    DMDMi74762559.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057380 mRNA. Translation: BAB71458.1 . Sequence problems.
    AK292228 mRNA. Translation: BAF84917.1 .
    BC034501 mRNA. Translation: AAH34501.1 .
    CCDSi CCDS12555.1.
    RefSeqi NP_653286.2. NM_144685.3.
    UniGenei Hs.79363.

    3D structure databases

    ProteinModelPortali Q8NE63.
    SMRi Q8NE63. Positions 9-371.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 127086. 29 interactions.
    IntActi Q8NE63. 24 interactions.
    STRINGi 9606.ENSP00000291823.

    Chemistry

    BindingDBi Q8NE63.
    ChEMBLi CHEMBL1075167.
    GuidetoPHARMACOLOGYi 2036.

    PTM databases

    PhosphoSitei Q8NE63.

    Polymorphism databases

    DMDMi 74762559.

    Proteomic databases

    PaxDbi Q8NE63.
    PRIDEi Q8NE63.

    Protocols and materials databases

    DNASUi 147746.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000291823 ; ENSP00000291823 ; ENSG00000160396 .
    GeneIDi 147746.
    KEGGi hsa:147746.
    UCSCi uc002onp.3. human.

    Organism-specific databases

    CTDi 147746.
    GeneCardsi GC19M040885.
    HGNCi HGNC:19007. HIPK4.
    HPAi HPA027733.
    MIMi 611712. gene.
    neXtProti NX_Q8NE63.
    PharmGKBi PA134883524.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000090252.
    HOVERGENi HBG081604.
    InParanoidi Q8NE63.
    KOi K08826.
    OMAi FREEKAP.
    OrthoDBi EOG7034GK.
    PhylomeDBi Q8NE63.
    TreeFami TF105417.

    Enzyme and pathway databases

    SignaLinki Q8NE63.

    Miscellaneous databases

    GenomeRNAii 147746.
    NextBioi 85724.
    PROi Q8NE63.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NE63.
    Bgeei Q8NE63.
    CleanExi HS_HIPK4.
    Genevestigatori Q8NE63.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-106; MET-171; MET-381; THR-386; ARG-406; SER-421 AND CYS-481.

    Entry informationi

    Entry nameiHIPK4_HUMAN
    AccessioniPrimary (citable) accession number: Q8NE63
    Secondary accession number(s): A8K863, Q96M54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: October 1, 2002
    Last modified: July 9, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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