Q8NE63 (HIPK4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeodomain-interacting protein kinase 4
EC=2.7.11.1

Gene names

Name:

HIPK4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	616 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter By similarity. May act as a corepressor of transcription factors Potential.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm By similarity.
Post-translational modification	Autophosphorylated By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. Contains 1 protein kinase domain.
Sequence caution	The sequence BAB71458.1 differs from that shown. Reason: Aberrant splicing.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 616	616	Homeodomain-interacting protein kinase 4		PRO_0000232401
Regions
	Domain	11 – 347	337	Protein kinase
	Nucleotide binding	17 – 25	9	ATP By similarity
Sites
	Active site	136	1	Proton acceptor By similarity
	Binding site	40	1	ATP By similarity
Natural variations
	Natural variant	106	1	A → T. Ref.3 Corresponds to variant rs34434715 [ dbSNP | Ensembl ].		VAR_040554
	Natural variant	171	1	V → M. Ref.3 Corresponds to variant rs55964225 [ dbSNP | Ensembl ].		VAR_040555
	Natural variant	302	1	R → Q. Corresponds to variant rs11670988 [ dbSNP | Ensembl ].		VAR_030578
	Natural variant	381	1	T → M. Ref.3 Corresponds to variant rs55760165 [ dbSNP | Ensembl ].		VAR_040556
	Natural variant	386	1	A → T. Ref.3 Corresponds to variant rs56365273 [ dbSNP | Ensembl ].		VAR_040557
	Natural variant	406	1	S → R. Ref.3 Corresponds to variant rs56094851 [ dbSNP | Ensembl ].		VAR_040558
	Natural variant	421	1	G → S. Ref.3 Corresponds to variant rs56117722 [ dbSNP | Ensembl ].		VAR_040559
	Natural variant	481	1	R → C. Ref.3 Corresponds to variant rs55801979 [ dbSNP | Ensembl ].		VAR_040560
Experimental info
	Sequence conflict	374	1	Q → R in BAB71458. Ref.1
	Sequence conflict	445	1	T → A in BAB71458. Ref.1
	Sequence conflict	581	1	E → G in BAF84917. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8NE63 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 02429E8F2070C6C0	FASTA	616	69,425
	10 20 30 40 50 60 MSTIQSETDC YDIIEVLGKG TFGEVAKGWR RSTGEMVAIK ILKNDAYRNR IIKNELKLLH 70 80 90 100 110 120 CMRGLDPEEA HVIRFLEFFH DALKFYLVFE LLEQNLFEFQ KENNFAPLPA RHIRTVTLQV 130 140 150 160 170 180 LTALARLKEL AIIHADLKPE NIMLVDQTRC PFRVKVIDFG SASIFSEVRY VKEPYIQSRF 190 200 210 220 230 240 YRAPEILLGL PFCEKVDVWS LGCVMAELHL GWPLYPGNNE YDQVRYICET QGLPKPHLLH 250 260 270 280 290 300 AACKAHHFFK RNPHPDAANP WQLKSSADYL AETKVRPLER RKYMLKSLDQ IETVNGGSVA 310 320 330 340 350 360 SRLTFPDREA LAEHADLKSM VELIKRMLTW ESHERISPSA ALRHPFVSMQ QLRSAHETTH 370 380 390 400 410 420 YYQLSLRSYR LSLQVEGKPP TPVVAAEDGT PYYCLAEEKE AAGMGSVAGS SPFFREEKAP 430 440 450 460 470 480 GMQRAIDQLD DLSLQEAGHG LWGETCTNAV SDMMVPLKAA ITGHHVPDSG PEPILAFYSS 490 500 510 520 530 540 RLAGRHKARK PPAGSKSDSN FSNLIRLSQV SPEDDRPCRG SSWEEGEHLG ASAEPLAILQ 550 560 570 580 590 600 RDEDGPNIDN MTMEAERPDP ELFDPSSCPG EWLSEPDCTL ESVRGPRAQG LPPRRSHQHG 610 PPRGATSFLQ HVTGHH

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-106; MET-171; MET-381; THR-386; ARG-406; SER-421 AND CYS-481.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK057380 mRNA. Translation: BAB71458.1. Sequence problems. AK292228 mRNA. Translation: BAF84917.1. BC034501 mRNA. Translation: AAH34501.1.
IPI	IPI00302130. IPI00387062.
RefSeq	NP_653286.2. NM_144685.3.
UniGene	Hs.79363.
3D structure databases
ProteinModelPortal	Q8NE63.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NE63. 1 interaction.
STRING	9606.ENSP00000291823.
PTM databases
PhosphoSite	Q8NE63.
Polymorphism databases
DMDM	74762559.
Proteomic databases
PaxDb	Q8NE63.
PRIDE	Q8NE63.
Protocols and materials databases
DNASU	147746.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000291823; ENSP00000291823; ENSG00000160396.
GeneID	147746.
KEGG	hsa:147746.
UCSC	uc002onp.3. human.
Organism-specific databases
CTD	147746.
GeneCards	GC19M040885.
HGNC	HGNC:19007. HIPK4.
HPA	HPA027733.
MIM	611712. gene.
neXtProt	NX_Q8NE63.
PharmGKB	PA134883524.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000090252.
HOVERGEN	HBG081604.
InParanoid	Q8NE63.
KO	K08826.
OMA	FREEKAP.
PhylomeDB	Q8NE63.
Enzyme and pathway databases
SignaLink	Q8NE63.
Gene expression databases
ArrayExpress	Q8NE63.
Bgee	Q8NE63.
CleanEx	HS_HIPK4.
Genevestigator	Q8NE63.
GermOnline	ENSG00000160396. Homo sapiens.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q8NE63.
ChEMBL	CHEMBL1075167.
GenomeRNAi	147746.
NextBio	85724.
SOURCE	Search...

Entry information

Entry name

HIPK4_HUMAN

Accession

Primary (citable) accession number: Q8NE63
Secondary accession number(s): A8K863, Q96M54

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 1, 2002
Last modified:	May 29, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.