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Protein

Homeodomain-interacting protein kinase 4

Gene

HIPK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential).By similarityCurated

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401ATPPROSITE-ProRule annotation
Active sitei136 – 1361Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 259ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8NE63.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeodomain-interacting protein kinase 4 (EC:2.7.11.1)
Gene namesi
Name:HIPK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:19007. HIPK4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134883524.

Polymorphism and mutation databases

BioMutaiHIPK4.
DMDMi74762559.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 616616Homeodomain-interacting protein kinase 4PRO_0000232401Add
BLAST

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8NE63.
PRIDEiQ8NE63.

PTM databases

PhosphoSiteiQ8NE63.

Expressioni

Gene expression databases

BgeeiQ8NE63.
CleanExiHS_HIPK4.
GenevisibleiQ8NE63. HS.

Organism-specific databases

HPAiHPA027733.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-6381114,EBI-743771

Protein-protein interaction databases

BioGridi127086. 30 interactions.
IntActiQ8NE63. 25 interactions.
STRINGi9606.ENSP00000291823.

Structurei

3D structure databases

ProteinModelPortaliQ8NE63.
SMRiQ8NE63. Positions 9-371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 347337Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000090252.
HOVERGENiHBG081604.
InParanoidiQ8NE63.
KOiK08826.
OMAiFREEKAP.
OrthoDBiEOG7034GK.
PhylomeDBiQ8NE63.
TreeFamiTF105417.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NE63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTIQSETDC YDIIEVLGKG TFGEVAKGWR RSTGEMVAIK ILKNDAYRNR
60 70 80 90 100
IIKNELKLLH CMRGLDPEEA HVIRFLEFFH DALKFYLVFE LLEQNLFEFQ
110 120 130 140 150
KENNFAPLPA RHIRTVTLQV LTALARLKEL AIIHADLKPE NIMLVDQTRC
160 170 180 190 200
PFRVKVIDFG SASIFSEVRY VKEPYIQSRF YRAPEILLGL PFCEKVDVWS
210 220 230 240 250
LGCVMAELHL GWPLYPGNNE YDQVRYICET QGLPKPHLLH AACKAHHFFK
260 270 280 290 300
RNPHPDAANP WQLKSSADYL AETKVRPLER RKYMLKSLDQ IETVNGGSVA
310 320 330 340 350
SRLTFPDREA LAEHADLKSM VELIKRMLTW ESHERISPSA ALRHPFVSMQ
360 370 380 390 400
QLRSAHETTH YYQLSLRSYR LSLQVEGKPP TPVVAAEDGT PYYCLAEEKE
410 420 430 440 450
AAGMGSVAGS SPFFREEKAP GMQRAIDQLD DLSLQEAGHG LWGETCTNAV
460 470 480 490 500
SDMMVPLKAA ITGHHVPDSG PEPILAFYSS RLAGRHKARK PPAGSKSDSN
510 520 530 540 550
FSNLIRLSQV SPEDDRPCRG SSWEEGEHLG ASAEPLAILQ RDEDGPNIDN
560 570 580 590 600
MTMEAERPDP ELFDPSSCPG EWLSEPDCTL ESVRGPRAQG LPPRRSHQHG
610
PPRGATSFLQ HVTGHH
Length:616
Mass (Da):69,425
Last modified:October 1, 2002 - v1
Checksum:i02429E8F2070C6C0
GO

Sequence cautioni

The sequence BAB71458.1 differs from that shown.Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti374 – 3741Q → R in BAB71458 (PubMed:14702039).Curated
Sequence conflicti445 – 4451T → A in BAB71458 (PubMed:14702039).Curated
Sequence conflicti581 – 5811E → G in BAF84917 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061A → T.1 Publication
Corresponds to variant rs34434715 [ dbSNP | Ensembl ].
VAR_040554
Natural varianti171 – 1711V → M.1 Publication
Corresponds to variant rs55964225 [ dbSNP | Ensembl ].
VAR_040555
Natural varianti302 – 3021R → Q.
Corresponds to variant rs11670988 [ dbSNP | Ensembl ].
VAR_030578
Natural varianti381 – 3811T → M.1 Publication
Corresponds to variant rs55760165 [ dbSNP | Ensembl ].
VAR_040556
Natural varianti386 – 3861A → T.1 Publication
Corresponds to variant rs56365273 [ dbSNP | Ensembl ].
VAR_040557
Natural varianti406 – 4061S → R.1 Publication
Corresponds to variant rs56094851 [ dbSNP | Ensembl ].
VAR_040558
Natural varianti421 – 4211G → S.1 Publication
Corresponds to variant rs56117722 [ dbSNP | Ensembl ].
VAR_040559
Natural varianti481 – 4811R → C.1 Publication
Corresponds to variant rs55801979 [ dbSNP | Ensembl ].
VAR_040560

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057380 mRNA. Translation: BAB71458.1. Sequence problems.
AK292228 mRNA. Translation: BAF84917.1.
BC034501 mRNA. Translation: AAH34501.1.
CCDSiCCDS12555.1.
RefSeqiNP_653286.2. NM_144685.4.
UniGeneiHs.79363.

Genome annotation databases

EnsembliENST00000291823; ENSP00000291823; ENSG00000160396.
GeneIDi147746.
KEGGihsa:147746.
UCSCiuc002onp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057380 mRNA. Translation: BAB71458.1. Sequence problems.
AK292228 mRNA. Translation: BAF84917.1.
BC034501 mRNA. Translation: AAH34501.1.
CCDSiCCDS12555.1.
RefSeqiNP_653286.2. NM_144685.4.
UniGeneiHs.79363.

3D structure databases

ProteinModelPortaliQ8NE63.
SMRiQ8NE63. Positions 9-371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127086. 30 interactions.
IntActiQ8NE63. 25 interactions.
STRINGi9606.ENSP00000291823.

Chemistry

BindingDBiQ8NE63.
ChEMBLiCHEMBL1075167.
GuidetoPHARMACOLOGYi2036.

PTM databases

PhosphoSiteiQ8NE63.

Polymorphism and mutation databases

BioMutaiHIPK4.
DMDMi74762559.

Proteomic databases

PaxDbiQ8NE63.
PRIDEiQ8NE63.

Protocols and materials databases

DNASUi147746.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291823; ENSP00000291823; ENSG00000160396.
GeneIDi147746.
KEGGihsa:147746.
UCSCiuc002onp.3. human.

Organism-specific databases

CTDi147746.
GeneCardsiGC19M040885.
HGNCiHGNC:19007. HIPK4.
HPAiHPA027733.
MIMi611712. gene.
neXtProtiNX_Q8NE63.
PharmGKBiPA134883524.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000090252.
HOVERGENiHBG081604.
InParanoidiQ8NE63.
KOiK08826.
OMAiFREEKAP.
OrthoDBiEOG7034GK.
PhylomeDBiQ8NE63.
TreeFamiTF105417.

Enzyme and pathway databases

SignaLinkiQ8NE63.

Miscellaneous databases

ChiTaRSiHIPK4. human.
GenomeRNAii147746.
NextBioi85724.
PROiQ8NE63.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NE63.
CleanExiHS_HIPK4.
GenevisibleiQ8NE63. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-106; MET-171; MET-381; THR-386; ARG-406; SER-421 AND CYS-481.

Entry informationi

Entry nameiHIPK4_HUMAN
AccessioniPrimary (citable) accession number: Q8NE63
Secondary accession number(s): A8K863, Q96M54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.