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Protein

Cytoplasmic polyadenylation element-binding protein 3

Gene

CPEB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • mRNA 3'-UTR AU-rich region binding Source: UniProtKB
  • mRNA 3'-UTR binding Source: UniProtKB
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • ribosome binding Source: GO_Central
  • RNA binding Source: UniProtKB
  • RNA stem-loop binding Source: UniProtKB
  • translation factor activity, RNA binding Source: UniProtKB
  • translation repressor activity, nucleic acid binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic polyadenylation element-binding protein 3
Short name:
CPE-BP3
Short name:
CPE-binding protein 3
Short name:
hCPEB-3
Gene namesi
Name:CPEB3
Synonyms:KIAA0940
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:21746. CPEB3.

Subcellular locationi

GO - Cellular componenti

  • apical dendrite Source: UniProtKB
  • CCR4-NOT complex Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • dendrite Source: UniProtKB
  • messenger ribonucleoprotein complex Source: GO_Central
  • neuron projection Source: UniProtKB
  • nucleus Source: UniProtKB
  • synapse Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903478.

Polymorphism and mutation databases

BioMutaiCPEB3.
DMDMi119368633.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 698698Cytoplasmic polyadenylation element-binding protein 3PRO_0000269261Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei192 – 1921PhosphoserineCombined sources
Modified residuei195 – 1951PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8NE35.
PaxDbiQ8NE35.
PRIDEiQ8NE35.

PTM databases

iPTMnetiQ8NE35.
PhosphoSiteiQ8NE35.

Expressioni

Gene expression databases

BgeeiQ8NE35.
CleanExiHS_CPEB3.
ExpressionAtlasiQ8NE35. baseline and differential.
GenevisibleiQ8NE35. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TOB1P506167EBI-8596191,EBI-723281

Protein-protein interaction databases

BioGridi116521. 1 interaction.
IntActiQ8NE35. 6 interactions.
STRINGi9606.ENSP00000265997.

Structurei

Secondary structure

1
698
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi443 – 4464Combined sources
Helixi454 – 4607Combined sources
Turni461 – 4644Combined sources
Beta strandi467 – 4704Combined sources
Beta strandi474 – 4774Combined sources
Beta strandi478 – 4814Combined sources
Beta strandi485 – 4895Combined sources
Helixi494 – 50310Combined sources
Beta strandi504 – 5074Combined sources
Beta strandi510 – 5156Combined sources
Beta strandi518 – 5203Combined sources
Beta strandi522 – 5287Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DNLNMR-A440-540[»]
2RUGNMR-A440-540[»]
ProteinModelPortaliQ8NE35.
SMRiQ8NE35. Positions 431-689.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NE35.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini441 – 53292RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini549 – 63183RRM 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi13 – 2715Gln-richAdd
BLAST
Compositional biasi26 – 200175Pro-richAdd
BLAST
Compositional biasi170 – 23869Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the RRM CPEB family.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0129. Eukaryota.
ENOG410Y1XZ. LUCA.
GeneTreeiENSGT00390000012886.
HOGENOMiHOG000290660.
HOVERGENiHBG058010.
InParanoidiQ8NE35.
KOiK02602.
OMAiKGRMGIN.
OrthoDBiEOG7X3QR2.
PhylomeDBiQ8NE35.
TreeFamiTF317658.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR032296. CEBP_ZZ.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF16366. CEBP_ZZ. 1 hit.
PF16367. RRM_7. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NE35-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQDDLLMDKS KTQPQPQQQQ RQQQQPQPES SVSEAPSTPL SSETPKPEEN
60 70 80 90 100
SAVPALSPAA APPAPNGPDK MQMESPLLPG LSFHQPPQQP PPPQEPAAPG
110 120 130 140 150
ASLSPSFGST WSTGTTNAVE DSFFQGITPV NGTMLFQNFP HHVNPVFGGT
160 170 180 190 200
FSPQIGLAQT QHHQQPPPPA PAPQPAQPAQ PPQAQPPQQR RSPASPSQAP
210 220 230 240 250
YAQRSAAAAY GHQPIMTSKP SSSSAVAAAA AAAAASSASS SWNTHQSVNA
260 270 280 290 300
AWSAPSNPWG GLQAGRDPRR AVGVGVGVGV GVPSPLNPIS PLKKPFSSNV
310 320 330 340 350
IAPPKFPRAA PLTSKSWMED NAFRTDNGNN LLPFQDRSRP YDTFNLHSLE
360 370 380 390 400
NSLMDMIRTD HEPLKGKHYP PSGPPMSFAD IMWRNHFAGR MGINFHHPGT
410 420 430 440 450
DNIMALNNAF LDDSHGDQAL SSGLSSPTRC QNGERVERYS RKVFVGGLPP
460 470 480 490 500
DIDEDEITAS FRRFGPLVVD WPHKAESKSY FPPKGYAFLL FQEESSVQAL
510 520 530 540 550
IDACLEEDGK LYLCVSSPTI KDKPVQIRPW NLSDSDFVMD GSQPLDPRKT
560 570 580 590 600
IFVGGVPRPL RAVELAMIMD RLYGGVCYAG IDTDPELKYP KGAGRVAFSN
610 620 630 640 650
QQSYIAAISA RFVQLQHNDI DKRVEVKPYV LDDQMCDECQ GTRCGGKFAP
660 670 680 690
FFCANVTCLQ YYCEYCWASI HSRAGREFHK PLVKEGGDRP RHVPFRWS
Length:698
Mass (Da):76,014
Last modified:December 12, 2006 - v2
Checksum:i0E67DCB7F8A40C96
GO
Isoform 2 (identifier: Q8NE35-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     366-388: Missing.
     408-408: N → SRSSLFPFED

Show »
Length:684
Mass (Da):74,440
Checksum:i7CD47A66E821AE71
GO

Sequence cautioni

The sequence BAA76784.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti519 – 5191Missing in AAH36444 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti324 – 3241R → W.1 Publication
Corresponds to variant rs17853616 [ dbSNP | Ensembl ].
VAR_029776

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei366 – 38823Missing in isoform 2. 1 PublicationVSP_022034Add
BLAST
Alternative sequencei408 – 4081N → SRSSLFPFED in isoform 2. 1 PublicationVSP_022035

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023157 mRNA. Translation: BAA76784.2. Different initiation.
AL158040, AL365398 Genomic DNA. Translation: CAI13636.1.
AL365398, AL158040 Genomic DNA. Translation: CAI14104.1.
BC036444 mRNA. Translation: AAH36444.1.
CCDSiCCDS31246.1. [Q8NE35-1]
CCDS53553.1. [Q8NE35-2]
RefSeqiNP_001171608.1. NM_001178137.1. [Q8NE35-2]
NP_055727.3. NM_014912.4. [Q8NE35-1]
XP_005269687.1. XM_005269630.3. [Q8NE35-2]
UniGeneiHs.131683.
Hs.701732.

Genome annotation databases

EnsembliENST00000265997; ENSP00000265997; ENSG00000107864. [Q8NE35-1]
ENST00000412050; ENSP00000398310; ENSG00000107864. [Q8NE35-2]
ENST00000614585; ENSP00000482128; ENSG00000107864. [Q8NE35-1]
GeneIDi22849.
KEGGihsa:22849.
UCSCiuc001khv.3. human. [Q8NE35-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023157 mRNA. Translation: BAA76784.2. Different initiation.
AL158040, AL365398 Genomic DNA. Translation: CAI13636.1.
AL365398, AL158040 Genomic DNA. Translation: CAI14104.1.
BC036444 mRNA. Translation: AAH36444.1.
CCDSiCCDS31246.1. [Q8NE35-1]
CCDS53553.1. [Q8NE35-2]
RefSeqiNP_001171608.1. NM_001178137.1. [Q8NE35-2]
NP_055727.3. NM_014912.4. [Q8NE35-1]
XP_005269687.1. XM_005269630.3. [Q8NE35-2]
UniGeneiHs.131683.
Hs.701732.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DNLNMR-A440-540[»]
2RUGNMR-A440-540[»]
ProteinModelPortaliQ8NE35.
SMRiQ8NE35. Positions 431-689.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116521. 1 interaction.
IntActiQ8NE35. 6 interactions.
STRINGi9606.ENSP00000265997.

PTM databases

iPTMnetiQ8NE35.
PhosphoSiteiQ8NE35.

Polymorphism and mutation databases

BioMutaiCPEB3.
DMDMi119368633.

Proteomic databases

MaxQBiQ8NE35.
PaxDbiQ8NE35.
PRIDEiQ8NE35.

Protocols and materials databases

DNASUi22849.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265997; ENSP00000265997; ENSG00000107864. [Q8NE35-1]
ENST00000412050; ENSP00000398310; ENSG00000107864. [Q8NE35-2]
ENST00000614585; ENSP00000482128; ENSG00000107864. [Q8NE35-1]
GeneIDi22849.
KEGGihsa:22849.
UCSCiuc001khv.3. human. [Q8NE35-1]

Organism-specific databases

CTDi22849.
GeneCardsiCPEB3.
HGNCiHGNC:21746. CPEB3.
MIMi610606. gene.
neXtProtiNX_Q8NE35.
PharmGKBiPA134903478.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0129. Eukaryota.
ENOG410Y1XZ. LUCA.
GeneTreeiENSGT00390000012886.
HOGENOMiHOG000290660.
HOVERGENiHBG058010.
InParanoidiQ8NE35.
KOiK02602.
OMAiKGRMGIN.
OrthoDBiEOG7X3QR2.
PhylomeDBiQ8NE35.
TreeFamiTF317658.

Miscellaneous databases

ChiTaRSiCPEB3. human.
EvolutionaryTraceiQ8NE35.
GenomeRNAii22849.
PROiQ8NE35.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NE35.
CleanExiHS_CPEB3.
ExpressionAtlasiQ8NE35. baseline and differential.
GenevisibleiQ8NE35. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR032296. CEBP_ZZ.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF16366. CEBP_ZZ. 1 hit.
PF16367. RRM_7. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TRP-324.
    Tissue: Testis.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-192, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Solution structure of RNA binding domain in cytoplasmic polyadenylation element binding protein 3."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 440-540.

Entry informationi

Entry nameiCPEB3_HUMAN
AccessioniPrimary (citable) accession number: Q8NE35
Secondary accession number(s): Q5T389, Q9NQJ7, Q9Y2E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: June 8, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.