ID STKL1_HUMAN Reviewed; 680 AA. AC Q8NE28; Q5T8U8; Q6ZMP6; Q6ZMQ5; DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot. DT 28-MAR-2018, sequence version 5. DT 27-MAR-2024, entry version 166. DE RecName: Full=Serine/threonine kinase-like domain-containing protein STKLD1; DE AltName: Full=Serine/threonine kinase-like domain-containing protein 1; DE AltName: Full=Sugen kinase 071; GN Name=STKLD1; Synonyms=C9orf96, SGK071; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). RC TISSUE=Amygdala, and Thalamus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., RA Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP IDENTIFICATION. RX PubMed=12471243; DOI=10.1126/science.1075762; RA Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S.; RT "The protein kinase complement of the human genome."; RL Science 298:1912-1934(2002). RN [5] RP VARIANT [LARGE SCALE ANALYSIS] ASP-139. RX PubMed=17344846; DOI=10.1038/nature05610; RA Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., RA Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., RA Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G., RA Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., RA Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., RA Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., RA Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., RA Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., RA Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., RA Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., RA Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., RA Futreal P.A., Stratton M.R.; RT "Patterns of somatic mutation in human cancer genomes."; RL Nature 446:153-158(2007). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q8NE28-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8NE28-2; Sequence=VSP_021658, VSP_021659; CC Name=3; CC IsoId=Q8NE28-3; Sequence=VSP_021660, VSP_021657; CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically CC inactive. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein CC kinase family. STKL subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}. CC -!- CAUTION: Asn-157 is present instead of the conserved Asp which is CC expected to be an active site residue. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=CAI12843.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK131533; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AK131545; BAD18679.1; -; mRNA. DR EMBL; AL158826; CAI12843.1; ALT_SEQ; Genomic_DNA. DR EMBL; AL593848; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC036504; AAH36504.3; -; mRNA. DR CCDS; CCDS35169.1; -. [Q8NE28-1] DR RefSeq; NP_714921.4; NM_153710.4. [Q8NE28-1] DR AlphaFoldDB; Q8NE28; -. DR SMR; Q8NE28; -. DR BioGRID; 127981; 5. DR STRING; 9606.ENSP00000361025; -. DR iPTMnet; Q8NE28; -. DR PhosphoSitePlus; Q8NE28; -. DR BioMuta; STKLD1; -. DR DMDM; 90111984; -. DR EPD; Q8NE28; -. DR jPOST; Q8NE28; -. DR MassIVE; Q8NE28; -. DR PaxDb; 9606-ENSP00000361025; -. DR PeptideAtlas; Q8NE28; -. DR ProteomicsDB; 73118; -. [Q8NE28-1] DR ProteomicsDB; 73119; -. [Q8NE28-2] DR ProteomicsDB; 73120; -. [Q8NE28-3] DR Antibodypedia; 31860; 233 antibodies from 23 providers. DR DNASU; 169436; -. DR Ensembl; ENST00000371957.4; ENSP00000361025.3; ENSG00000198870.8. [Q8NE28-1] DR Ensembl; ENST00000627962.2; ENSP00000486786.1; ENSG00000281245.2. [Q8NE28-1] DR GeneID; 169436; -. DR KEGG; hsa:169436; -. DR MANE-Select; ENST00000371957.4; ENSP00000361025.3; NM_153710.5; NP_714921.4. DR UCSC; uc033dkl.2; human. [Q8NE28-1] DR AGR; HGNC:28669; -. DR CTD; 169436; -. DR DisGeNET; 169436; -. DR GeneCards; STKLD1; -. DR HGNC; HGNC:28669; STKLD1. DR HPA; ENSG00000198870; Tissue enriched (testis). DR MIM; 618530; gene. DR neXtProt; NX_Q8NE28; -. DR OpenTargets; ENSG00000198870; -. DR PharmGKB; PA134891744; -. DR VEuPathDB; HostDB:ENSG00000198870; -. DR eggNOG; KOG0589; Eukaryota. DR GeneTree; ENSGT00390000018038; -. DR HOGENOM; CLU_013402_0_0_1; -. DR InParanoid; Q8NE28; -. DR OMA; MDSTEAM; -. DR OrthoDB; 4264730at2759; -. DR PhylomeDB; Q8NE28; -. DR TreeFam; TF336364; -. DR PathwayCommons; Q8NE28; -. DR SignaLink; Q8NE28; -. DR BioGRID-ORCS; 169436; 13 hits in 1176 CRISPR screens. DR ChiTaRS; STKLD1; human. DR GenomeRNAi; 169436; -. DR Pharos; Q8NE28; Tdark. DR PRO; PR:Q8NE28; -. DR Proteomes; UP000005640; Chromosome 9. DR RNAct; Q8NE28; Protein. DR Bgee; ENSG00000198870; Expressed in right testis and 97 other cell types or tissues. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central. DR CDD; cd00180; PKc; 1. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR PANTHER; PTHR24363; SERINE/THREONINE PROTEIN KINASE; 1. DR PANTHER; PTHR24363:SF5; SERINE_THREONINE KINASE-LIKE DOMAIN-CONTAINING PROTEIN STKLD1; 1. DR Pfam; PF00069; Pkinase; 1. DR SUPFAM; SSF48371; ARM repeat; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR Genevisible; Q8NE28; HS. PE 2: Evidence at transcript level; KW Alternative splicing; ATP-binding; Nucleotide-binding; Reference proteome. FT CHAIN 1..680 FT /note="Serine/threonine kinase-like domain-containing FT protein STKLD1" FT /id="PRO_0000227568" FT DOMAIN 28..297 FT /note="Protein kinase" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT REGION 1..25 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 658..680 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 34..42 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT BINDING 57 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT VAR_SEQ 1..375 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_021658" FT VAR_SEQ 133..226 FT /note="WMQNVLGQVLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNVLMTD FT KAKWNIRAEEDPFRKSWMAPEALNFSFSQKSDIWSLGCIILD -> IKTEGVPNTRRFP FT VGDHDSRLFCRSLKFLMDSSGMLPLLSGLLPSACCCEPRGAAACTSKSCVHCLLPLCCL FT IALQAVYLVSFGLLPVWGYCE (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_021660" FT VAR_SEQ 227..680 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_021657" FT VAR_SEQ 400..491 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_021659" FT VARIANT 139 FT /note="G -> D (in a glioblastoma multiforme sample; somatic FT mutation)" FT /evidence="ECO:0000269|PubMed:17344846" FT /id="VAR_041371" FT VARIANT 473 FT /note="E -> K (in dbSNP:rs3124747)" FT /id="VAR_025611" FT VARIANT 568 FT /note="R -> Q (in dbSNP:rs17150554)" FT /id="VAR_025612" SQ SEQUENCE 680 AA; 75677 MW; F4A7477B98900EA8 CRC64; MLGPGSNRRR PTQGERGPGS PGEPMEKYQV LYQLNPGALG VNLVVEEMET KVKHVIKQVE CMDDHYASQA LEELMPLLKL RHAHISVYQE LFITWNGEIS SLYLCLVMEF NELSFQEVIE DKRKAKKIID SEWMQNVLGQ VLDALEYLHH LDIIHRNLKP SNIILISSDH CKLQDLSSNV LMTDKAKWNI RAEEDPFRKS WMAPEALNFS FSQKSDIWSL GCIILDMTSC SFMDGTEAMH LRKSLRQSPG SLKAVLKTME EKQIPDVETF RNLLPLMLQI DPSDRITIKD VVHITFLRGS FKSSCVSLTL HRQMVPASIT DMLLEGNVAS ILEVMQKFSG WPEVQLRAMK RLLKMPADQL GLPWPPELVE VVVTTMELHD RVLDVQLCAC SLLLHLLGQA LVHHPEAKAP CNQAITSTLL SALQSHPEEE PLLVMVYSLL AITTTQESES LSEELQNAGL LEHILEHLNS SLESRDVCAS GLGLLWALLL DGIIVNKAPL EKVPDLISQV LATYPADGEM AEASCGVFWL LSLLGCIKEQ QFEQVVALLL QSIRLCQDRA LLVNNAYRGL ASLVKVSELA AFKVVVQEEG GSGLSLIKET YQLHRDDPEV VENVGMLLVH LASYEEILPE LVSSSMKALL QEIKERFTSS LVSDSSAFSK PGLPPGGSPQ LGCTTSGGLE //