Q8NE28 (SGK71_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inactive protein kinase-like protein SgK071

Alternative name(s):
Sugen kinase 071

Gene names

Name:	SGK071
Synonyms:	C9orf96

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	680 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Domain	The protein kinase domain is predicted to be catalytically inactive.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily. Contains 1 protein kinase domain.
Caution	Asn-157 is present instead of the conserved Asp which is expected to be an active site residue.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NE28-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NE28-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-375: Missing.
     400-491: Missing.

Isoform 3 (identifier: Q8NE28-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-467: Missing.
     468-491: LNSSLKSRDVCASGLGLLWALLLD → MGDGKAPLHTPKAWVSPSIPVLVP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 680	680	Probable inactive protein kinase-like protein SgK071		PRO_0000227568
Regions
	Domain	28 – 297	270	Protein kinase
	Nucleotide binding	34 – 42	9	ATP By similarity
Sites
	Binding site	57	1	ATP By similarity
Natural variations
	Alternative sequence	1 – 467	467	Missing in isoform 3.		VSP_021657
	Alternative sequence	1 – 375	375	Missing in isoform 2.		VSP_021658
	Alternative sequence	400 – 491	92	Missing in isoform 2.		VSP_021659
	Alternative sequence	468 – 491	24	LNSSL…ALLLD → MGDGKAPLHTPKAWVSPSIP VLVP in isoform 3.		VSP_021660
	Natural variant	139	1	G → D in a glioblastoma multiforme sample; somatic mutation. Ref.5		VAR_041371
	Natural variant	473	1	K → E. Ref.3 Corresponds to variant rs3124747 [ dbSNP | Ensembl ].		VAR_025611
	Natural variant	568	1	R → Q. Corresponds to variant rs17150554 [ dbSNP | Ensembl ].		VAR_025612

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 21, 2006. Version 4. Checksum: E0ED09D19CDEA4AF	FASTA	680	75,676
	10 20 30 40 50 60 MLGPGSNRRR PTQGERGPGS PGEPMEKYQV LYQLNPGALG VNLVVEEMET KVKHVIKQVE 70 80 90 100 110 120 CMDDHYASQA LEELMPLLKL RHAHISVYQE LFITWNGEIS SLYLCLVMEF NELSFQEVIE 130 140 150 160 170 180 DKRKAKKIID SEWMQNVLGQ VLDALEYLHH LDIIHRNLKP SNIILISSDH CKLQDLSSNV 190 200 210 220 230 240 LMTDKAKWNI RAEEDPFRKS WMAPEALNFS FSQKSDIWSL GCIILDMTSC SFMDGTEAMH 250 260 270 280 290 300 LRKSLRQSPG SLKAVLKTME EKQIPDVETF RNLLPLMLQI DPSDRITIKD VVHITFLRGS 310 320 330 340 350 360 FKSSCVSLTL HRQMVPASIT DMLLEGNVAS ILEVMQKFSG WPEVQLRAMK RLLKMPADQL 370 380 390 400 410 420 GLPWPPELVE VVVTTMELHD RVLDVQLCAC SLLLHLLGQA LVHHPEAKAP CNQAITSTLL 430 440 450 460 470 480 SALQSHPEEE PLLVMVYSLL AITTTQESES LSEELQNAGL LEHILEHLNS SLKSRDVCAS 490 500 510 520 530 540 GLGLLWALLL DGIIVNKAPL EKVPDLISQV LATYPADGEM AEASCGVFWL LSLLGCIKEQ 550 560 570 580 590 600 QFEQVVALLL QSIRLCQDRA LLVNNAYRGL ASLVKVSELA AFKVVVQEEG GSGLSLIKET 610 620 630 640 650 660 YQLHRDDPEV VENVGMLLVH LASYEEILPE LVSSSMKALL QEIKERFTSS LVSDSSAFSK 670 680 PGLPPGGSPQ LGCTTSGGLE
	Isoform 2 [UniParc]. Checksum: F741B9E047CEB449	FASTA	213	22,990
	10 20 30 40 50 60 MELHDRVLDV QLCACSLLLH LLGQGIIVNK APLEKVPDLI SQVLATYPAD GEMAEASCGV 70 80 90 100 110 120 FWLLSLLGCI KEQQFEQVVA LLLQSIRLCQ DRALLVNNAY RGLASLVKVS ELAAFKVVVQ 130 140 150 160 170 180 EEGGSGLSLI KETYQLHRDD PEVVENVGML LVHLASYEEI LPELVSSSMK ALLQEIKERF 190 200 210 TSSLVSDSSA FSKPGLPPGG SPQLGCTTSG GLE
	Isoform 3 [UniParc]. Checksum: 6C9377132B3D1378	FASTA	213	22,767
	10 20 30 40 50 60 MGDGKAPLHT PKAWVSPSIP VLVPGIIVNK APLEKVPDLI SQVLATYPAD GEMAEASCGV 70 80 90 100 110 120 FWLLSLLGCI KEQQFEQVVA LLLQSIRLCQ DRALLVNNAY RGLASLVKVS ELAAFKVVVQ 130 140 150 160 170 180 EEGGSGLSLI KETYQLHRDD PEVVENVGML LVHLASYEEI LPELVSSSMK ALLQEIKERF 190 200 210 TSSLVSDSSA FSKPGLPPGG SPQLGCTTSG GLE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Amygdala and Thalamus.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-473. Tissue: Testis.
[4]	"The protein kinase complement of the human genome." Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S. Science 298:1912-1934(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-139.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK131533 mRNA. No translation available. AK131545 mRNA. Translation: BAD18679.1. AL158826 Genomic DNA. Translation: CAI12843.1. BC036504 mRNA. Translation: AAH36504.3.
IPI	IPI00442015. IPI00470568. IPI00807445.
RefSeq	NP_714921.3. NM_153710.3.
UniGene	Hs.720195.
3D structure databases
ProteinModelPortal	Q8NE28.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000361025.
PTM databases
PhosphoSite	Q8NE28.
Polymorphism databases
DMDM	90111984.
Proteomic databases
PaxDb	Q8NE28.
PRIDE	Q8NE28.
Protocols and materials databases
DNASU	169436.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371955; ENSP00000361023; ENSG00000198870. ENST00000371957; ENSP00000361025; ENSG00000198870. ENST00000570203; ENSP00000454291; ENSG00000260489.
GeneID	169436.
KEGG	hsa:169436.
UCSC	uc004cdk.3. human.
Organism-specific databases
CTD	169436.
GeneCards	GC09P136243.
H-InvDB	HIX0034803. HIX0035032.
HGNC	HGNC:28669. C9orf96.
HPA	HPA029902.
neXtProt	NX_Q8NE28.
PharmGKB	PA134891744.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000054200.
HOVERGEN	HBG056774.
InParanoid	Q8NE28.
OMA	MTDKAKW.
OrthoDB	EOG4CJVGQ.
Gene expression databases
ArrayExpress	Q8NE28.
Bgee	Q8NE28.
Genevestigator	Q8NE28.
GermOnline	ENSG00000198870. Homo sapiens.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	C9orf96. human.
GenomeRNAi	169436.
NextBio	88811.

Entry information

Entry name

SGK71_HUMAN

Accession

Primary (citable) accession number: Q8NE28
Secondary accession number(s): Q5T8U8, Q6ZMP6, Q6ZMQ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	March 21, 2006
Last modified:	May 1, 2013
This is version 97 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.