Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8NE28

- STKL1_HUMAN

UniProt

Q8NE28 - STKL1_HUMAN

Protein

Serine/threonine kinase-like domain-containing protein STKLD1

Gene

STKLD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 4 (21 Mar 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei57 – 571ATPPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi34 – 429ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein kinase activity Source: InterPro

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ8NE28.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine kinase-like domain-containing protein STKLD1
    Alternative name(s):
    Serine/threonine kinase-like domain-containing protein 1
    Sugen kinase 071
    Gene namesi
    Name:STKLD1
    Synonyms:C9orf96, SGK071
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:28669. STKLD1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134891744.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 680680Serine/threonine kinase-like domain-containing protein STKLD1PRO_0000227568Add
    BLAST

    Proteomic databases

    PaxDbiQ8NE28.
    PRIDEiQ8NE28.

    PTM databases

    PhosphoSiteiQ8NE28.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NE28.
    BgeeiQ8NE28.
    GenevestigatoriQ8NE28.

    Organism-specific databases

    HPAiHPA029902.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NE28.
    SMRiQ8NE28. Positions 23-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 297270Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The protein kinase domain is predicted to be catalytically inactive.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000054200.
    HOVERGENiHBG056774.
    InParanoidiQ8NE28.
    KOiK17546.
    OMAiNCINCKH.
    PhylomeDBiQ8NE28.
    TreeFamiTF336364.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NE28-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLGPGSNRRR PTQGERGPGS PGEPMEKYQV LYQLNPGALG VNLVVEEMET    50
    KVKHVIKQVE CMDDHYASQA LEELMPLLKL RHAHISVYQE LFITWNGEIS 100
    SLYLCLVMEF NELSFQEVIE DKRKAKKIID SEWMQNVLGQ VLDALEYLHH 150
    LDIIHRNLKP SNIILISSDH CKLQDLSSNV LMTDKAKWNI RAEEDPFRKS 200
    WMAPEALNFS FSQKSDIWSL GCIILDMTSC SFMDGTEAMH LRKSLRQSPG 250
    SLKAVLKTME EKQIPDVETF RNLLPLMLQI DPSDRITIKD VVHITFLRGS 300
    FKSSCVSLTL HRQMVPASIT DMLLEGNVAS ILEVMQKFSG WPEVQLRAMK 350
    RLLKMPADQL GLPWPPELVE VVVTTMELHD RVLDVQLCAC SLLLHLLGQA 400
    LVHHPEAKAP CNQAITSTLL SALQSHPEEE PLLVMVYSLL AITTTQESES 450
    LSEELQNAGL LEHILEHLNS SLKSRDVCAS GLGLLWALLL DGIIVNKAPL 500
    EKVPDLISQV LATYPADGEM AEASCGVFWL LSLLGCIKEQ QFEQVVALLL 550
    QSIRLCQDRA LLVNNAYRGL ASLVKVSELA AFKVVVQEEG GSGLSLIKET 600
    YQLHRDDPEV VENVGMLLVH LASYEEILPE LVSSSMKALL QEIKERFTSS 650
    LVSDSSAFSK PGLPPGGSPQ LGCTTSGGLE 680
    Length:680
    Mass (Da):75,676
    Last modified:March 21, 2006 - v4
    Checksum:iE0ED09D19CDEA4AF
    GO
    Isoform 2 (identifier: Q8NE28-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-375: Missing.
         400-491: Missing.

    Show »
    Length:213
    Mass (Da):22,990
    Checksum:iF741B9E047CEB449
    GO
    Isoform 3 (identifier: Q8NE28-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-467: Missing.
         468-491: LNSSLKSRDVCASGLGLLWALLLD → MGDGKAPLHTPKAWVSPSIPVLVP

    Show »
    Length:213
    Mass (Da):22,767
    Checksum:i6C9377132B3D1378
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti139 – 1391G → D in a glioblastoma multiforme sample; somatic mutation. 1 Publication
    VAR_041371
    Natural varianti473 – 4731K → E.1 Publication
    Corresponds to variant rs3124747 [ dbSNP | Ensembl ].
    VAR_025611
    Natural varianti568 – 5681R → Q.
    Corresponds to variant rs17150554 [ dbSNP | Ensembl ].
    VAR_025612

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 467467Missing in isoform 3. 1 PublicationVSP_021657Add
    BLAST
    Alternative sequencei1 – 375375Missing in isoform 2. 1 PublicationVSP_021658Add
    BLAST
    Alternative sequencei400 – 49192Missing in isoform 2. 1 PublicationVSP_021659Add
    BLAST
    Alternative sequencei468 – 49124LNSSL…ALLLD → MGDGKAPLHTPKAWVSPSIP VLVP in isoform 3. 1 PublicationVSP_021660Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK131533 mRNA. No translation available.
    AK131545 mRNA. Translation: BAD18679.1.
    AL158826 Genomic DNA. Translation: CAI12843.1.
    BC036504 mRNA. Translation: AAH36504.3.
    CCDSiCCDS35169.1. [Q8NE28-1]
    RefSeqiNP_714921.4. NM_153710.4.
    UniGeneiHs.720195.

    Genome annotation databases

    EnsembliENST00000371957; ENSP00000361025; ENSG00000198870. [Q8NE28-1]
    GeneIDi169436.
    KEGGihsa:169436.
    UCSCiuc004cdk.3. human. [Q8NE28-1]

    Polymorphism databases

    DMDMi90111984.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK131533 mRNA. No translation available.
    AK131545 mRNA. Translation: BAD18679.1 .
    AL158826 Genomic DNA. Translation: CAI12843.1 .
    BC036504 mRNA. Translation: AAH36504.3 .
    CCDSi CCDS35169.1. [Q8NE28-1 ]
    RefSeqi NP_714921.4. NM_153710.4.
    UniGenei Hs.720195.

    3D structure databases

    ProteinModelPortali Q8NE28.
    SMRi Q8NE28. Positions 23-325.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8NE28.

    Polymorphism databases

    DMDMi 90111984.

    Proteomic databases

    PaxDbi Q8NE28.
    PRIDEi Q8NE28.

    Protocols and materials databases

    DNASUi 169436.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371957 ; ENSP00000361025 ; ENSG00000198870 . [Q8NE28-1 ]
    GeneIDi 169436.
    KEGGi hsa:169436.
    UCSCi uc004cdk.3. human. [Q8NE28-1 ]

    Organism-specific databases

    CTDi 169436.
    GeneCardsi GC09P136243.
    H-InvDB HIX0034803.
    HIX0035032.
    HGNCi HGNC:28669. STKLD1.
    HPAi HPA029902.
    neXtProti NX_Q8NE28.
    PharmGKBi PA134891744.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000054200.
    HOVERGENi HBG056774.
    InParanoidi Q8NE28.
    KOi K17546.
    OMAi NCINCKH.
    PhylomeDBi Q8NE28.
    TreeFami TF336364.

    Enzyme and pathway databases

    SignaLinki Q8NE28.

    Miscellaneous databases

    ChiTaRSi C9orf96. human.
    GenomeRNAii 169436.
    NextBioi 88811.
    PROi Q8NE28.

    Gene expression databases

    ArrayExpressi Q8NE28.
    Bgeei Q8NE28.
    Genevestigatori Q8NE28.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Amygdala and Thalamus.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-473.
      Tissue: Testis.
    4. Cited for: IDENTIFICATION.
    5. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-139.

    Entry informationi

    Entry nameiSTKL1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NE28
    Secondary accession number(s): Q5T8U8, Q6ZMP6, Q6ZMQ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 112 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Asn-157 is present instead of the conserved Asp which is expected to be an active site residue.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3