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Protein

Serine/threonine kinase-like domain-containing protein STKLD1

Gene

STKLD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571ATPPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 429ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein kinase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8NE28.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine kinase-like domain-containing protein STKLD1
Alternative name(s):
Serine/threonine kinase-like domain-containing protein 1
Sugen kinase 071
Gene namesi
Name:STKLD1
Synonyms:C9orf96, SGK071
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:28669. STKLD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134891744.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 680680Serine/threonine kinase-like domain-containing protein STKLD1PRO_0000227568Add
BLAST

Proteomic databases

PaxDbiQ8NE28.
PRIDEiQ8NE28.

PTM databases

PhosphoSiteiQ8NE28.

Expressioni

Gene expression databases

BgeeiQ8NE28.
GenevestigatoriQ8NE28.

Organism-specific databases

HPAiHPA029902.

Interactioni

Protein-protein interaction databases

BioGridi127981. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8NE28.
SMRiQ8NE28. Positions 23-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 297270Protein kinasePROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000054200.
HOVERGENiHBG056774.
InParanoidiQ8NE28.
KOiK17546.
OMAiCEIWHIS.
PhylomeDBiQ8NE28.
TreeFamiTF336364.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NE28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGPGSNRRR PTQGERGPGS PGEPMEKYQV LYQLNPGALG VNLVVEEMET
60 70 80 90 100
KVKHVIKQVE CMDDHYASQA LEELMPLLKL RHAHISVYQE LFITWNGEIS
110 120 130 140 150
SLYLCLVMEF NELSFQEVIE DKRKAKKIID SEWMQNVLGQ VLDALEYLHH
160 170 180 190 200
LDIIHRNLKP SNIILISSDH CKLQDLSSNV LMTDKAKWNI RAEEDPFRKS
210 220 230 240 250
WMAPEALNFS FSQKSDIWSL GCIILDMTSC SFMDGTEAMH LRKSLRQSPG
260 270 280 290 300
SLKAVLKTME EKQIPDVETF RNLLPLMLQI DPSDRITIKD VVHITFLRGS
310 320 330 340 350
FKSSCVSLTL HRQMVPASIT DMLLEGNVAS ILEVMQKFSG WPEVQLRAMK
360 370 380 390 400
RLLKMPADQL GLPWPPELVE VVVTTMELHD RVLDVQLCAC SLLLHLLGQA
410 420 430 440 450
LVHHPEAKAP CNQAITSTLL SALQSHPEEE PLLVMVYSLL AITTTQESES
460 470 480 490 500
LSEELQNAGL LEHILEHLNS SLKSRDVCAS GLGLLWALLL DGIIVNKAPL
510 520 530 540 550
EKVPDLISQV LATYPADGEM AEASCGVFWL LSLLGCIKEQ QFEQVVALLL
560 570 580 590 600
QSIRLCQDRA LLVNNAYRGL ASLVKVSELA AFKVVVQEEG GSGLSLIKET
610 620 630 640 650
YQLHRDDPEV VENVGMLLVH LASYEEILPE LVSSSMKALL QEIKERFTSS
660 670 680
LVSDSSAFSK PGLPPGGSPQ LGCTTSGGLE
Length:680
Mass (Da):75,676
Last modified:March 21, 2006 - v4
Checksum:iE0ED09D19CDEA4AF
GO
Isoform 2 (identifier: Q8NE28-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-375: Missing.
     400-491: Missing.

Show »
Length:213
Mass (Da):22,990
Checksum:iF741B9E047CEB449
GO
Isoform 3 (identifier: Q8NE28-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-467: Missing.
     468-491: LNSSLKSRDVCASGLGLLWALLLD → MGDGKAPLHTPKAWVSPSIPVLVP

Show »
Length:213
Mass (Da):22,767
Checksum:i6C9377132B3D1378
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti139 – 1391G → D in a glioblastoma multiforme sample; somatic mutation. 1 Publication
VAR_041371
Natural varianti473 – 4731K → E.1 Publication
Corresponds to variant rs3124747 [ dbSNP | Ensembl ].
VAR_025611
Natural varianti568 – 5681R → Q.
Corresponds to variant rs17150554 [ dbSNP | Ensembl ].
VAR_025612

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 467467Missing in isoform 3. 1 PublicationVSP_021657Add
BLAST
Alternative sequencei1 – 375375Missing in isoform 2. 1 PublicationVSP_021658Add
BLAST
Alternative sequencei400 – 49192Missing in isoform 2. 1 PublicationVSP_021659Add
BLAST
Alternative sequencei468 – 49124LNSSL…ALLLD → MGDGKAPLHTPKAWVSPSIP VLVP in isoform 3. 1 PublicationVSP_021660Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131533 mRNA. No translation available.
AK131545 mRNA. Translation: BAD18679.1.
AL158826 Genomic DNA. Translation: CAI12843.1.
BC036504 mRNA. Translation: AAH36504.3.
CCDSiCCDS35169.1. [Q8NE28-1]
RefSeqiNP_714921.4. NM_153710.4.
UniGeneiHs.720195.

Genome annotation databases

EnsembliENST00000371957; ENSP00000361025; ENSG00000198870.
GeneIDi169436.
KEGGihsa:169436.
UCSCiuc004cdk.3. human. [Q8NE28-1]

Polymorphism databases

DMDMi90111984.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131533 mRNA. No translation available.
AK131545 mRNA. Translation: BAD18679.1.
AL158826 Genomic DNA. Translation: CAI12843.1.
BC036504 mRNA. Translation: AAH36504.3.
CCDSiCCDS35169.1. [Q8NE28-1]
RefSeqiNP_714921.4. NM_153710.4.
UniGeneiHs.720195.

3D structure databases

ProteinModelPortaliQ8NE28.
SMRiQ8NE28. Positions 23-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127981. 1 interaction.

PTM databases

PhosphoSiteiQ8NE28.

Polymorphism databases

DMDMi90111984.

Proteomic databases

PaxDbiQ8NE28.
PRIDEiQ8NE28.

Protocols and materials databases

DNASUi169436.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371957; ENSP00000361025; ENSG00000198870.
GeneIDi169436.
KEGGihsa:169436.
UCSCiuc004cdk.3. human. [Q8NE28-1]

Organism-specific databases

CTDi169436.
GeneCardsiGC09P136243.
H-InvDBHIX0034803.
HIX0035032.
HGNCiHGNC:28669. STKLD1.
HPAiHPA029902.
neXtProtiNX_Q8NE28.
PharmGKBiPA134891744.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000054200.
HOVERGENiHBG056774.
InParanoidiQ8NE28.
KOiK17546.
OMAiCEIWHIS.
PhylomeDBiQ8NE28.
TreeFamiTF336364.

Enzyme and pathway databases

SignaLinkiQ8NE28.

Miscellaneous databases

ChiTaRSiC9orf96. human.
GenomeRNAii169436.
NextBioi88811.
PROiQ8NE28.

Gene expression databases

BgeeiQ8NE28.
GenevestigatoriQ8NE28.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Amygdala and Thalamus.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-473.
    Tissue: Testis.
  4. Cited for: IDENTIFICATION.
  5. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-139.

Entry informationi

Entry nameiSTKL1_HUMAN
AccessioniPrimary (citable) accession number: Q8NE28
Secondary accession number(s): Q5T8U8, Q6ZMP6, Q6ZMQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: March 4, 2015
This is version 115 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Asn-157 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.