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Q8NE28

- STKL1_HUMAN

UniProt

Q8NE28 - STKL1_HUMAN

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Protein
Serine/threonine kinase-like domain-containing protein STKLD1
Gene
STKLD1, C9orf96, SGK071
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 429ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein kinase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8NE28.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine kinase-like domain-containing protein STKLD1
Alternative name(s):
Serine/threonine kinase-like domain-containing protein 1
Sugen kinase 071
Gene namesi
Name:STKLD1
Synonyms:C9orf96, SGK071
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:28669. STKLD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134891744.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 680680Serine/threonine kinase-like domain-containing protein STKLD1
PRO_0000227568Add
BLAST

Proteomic databases

PaxDbiQ8NE28.
PRIDEiQ8NE28.

PTM databases

PhosphoSiteiQ8NE28.

Expressioni

Gene expression databases

ArrayExpressiQ8NE28.
BgeeiQ8NE28.
GenevestigatoriQ8NE28.

Organism-specific databases

HPAiHPA029902.

Structurei

3D structure databases

ProteinModelPortaliQ8NE28.
SMRiQ8NE28. Positions 23-325.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 297270Protein kinase
Add
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000054200.
HOVERGENiHBG056774.
InParanoidiQ8NE28.
KOiK17546.
OMAiNCINCKH.
PhylomeDBiQ8NE28.
TreeFamiTF336364.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NE28-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLGPGSNRRR PTQGERGPGS PGEPMEKYQV LYQLNPGALG VNLVVEEMET    50
KVKHVIKQVE CMDDHYASQA LEELMPLLKL RHAHISVYQE LFITWNGEIS 100
SLYLCLVMEF NELSFQEVIE DKRKAKKIID SEWMQNVLGQ VLDALEYLHH 150
LDIIHRNLKP SNIILISSDH CKLQDLSSNV LMTDKAKWNI RAEEDPFRKS 200
WMAPEALNFS FSQKSDIWSL GCIILDMTSC SFMDGTEAMH LRKSLRQSPG 250
SLKAVLKTME EKQIPDVETF RNLLPLMLQI DPSDRITIKD VVHITFLRGS 300
FKSSCVSLTL HRQMVPASIT DMLLEGNVAS ILEVMQKFSG WPEVQLRAMK 350
RLLKMPADQL GLPWPPELVE VVVTTMELHD RVLDVQLCAC SLLLHLLGQA 400
LVHHPEAKAP CNQAITSTLL SALQSHPEEE PLLVMVYSLL AITTTQESES 450
LSEELQNAGL LEHILEHLNS SLKSRDVCAS GLGLLWALLL DGIIVNKAPL 500
EKVPDLISQV LATYPADGEM AEASCGVFWL LSLLGCIKEQ QFEQVVALLL 550
QSIRLCQDRA LLVNNAYRGL ASLVKVSELA AFKVVVQEEG GSGLSLIKET 600
YQLHRDDPEV VENVGMLLVH LASYEEILPE LVSSSMKALL QEIKERFTSS 650
LVSDSSAFSK PGLPPGGSPQ LGCTTSGGLE 680
Length:680
Mass (Da):75,676
Last modified:March 21, 2006 - v4
Checksum:iE0ED09D19CDEA4AF
GO
Isoform 2 (identifier: Q8NE28-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-375: Missing.
     400-491: Missing.

Show »
Length:213
Mass (Da):22,990
Checksum:iF741B9E047CEB449
GO
Isoform 3 (identifier: Q8NE28-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-467: Missing.
     468-491: LNSSLKSRDVCASGLGLLWALLLD → MGDGKAPLHTPKAWVSPSIPVLVP

Show »
Length:213
Mass (Da):22,767
Checksum:i6C9377132B3D1378
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti139 – 1391G → D in a glioblastoma multiforme sample; somatic mutation. 1 Publication
VAR_041371
Natural varianti473 – 4731K → E.1 Publication
Corresponds to variant rs3124747 [ dbSNP | Ensembl ].
VAR_025611
Natural varianti568 – 5681R → Q.
Corresponds to variant rs17150554 [ dbSNP | Ensembl ].
VAR_025612

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 467467Missing in isoform 3.
VSP_021657Add
BLAST
Alternative sequencei1 – 375375Missing in isoform 2.
VSP_021658Add
BLAST
Alternative sequencei400 – 49192Missing in isoform 2.
VSP_021659Add
BLAST
Alternative sequencei468 – 49124LNSSL…ALLLD → MGDGKAPLHTPKAWVSPSIP VLVP in isoform 3.
VSP_021660Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK131533 mRNA. No translation available.
AK131545 mRNA. Translation: BAD18679.1.
AL158826 Genomic DNA. Translation: CAI12843.1.
BC036504 mRNA. Translation: AAH36504.3.
CCDSiCCDS35169.1. [Q8NE28-1]
RefSeqiNP_714921.4. NM_153710.4.
UniGeneiHs.720195.

Genome annotation databases

EnsembliENST00000371955; ENSP00000361023; ENSG00000198870. [Q8NE28-2]
ENST00000371957; ENSP00000361025; ENSG00000198870. [Q8NE28-1]
ENST00000570203; ENSP00000454291; ENSG00000260489.
GeneIDi169436.
KEGGihsa:169436.
UCSCiuc004cdk.3. human. [Q8NE28-1]

Polymorphism databases

DMDMi90111984.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK131533 mRNA. No translation available.
AK131545 mRNA. Translation: BAD18679.1 .
AL158826 Genomic DNA. Translation: CAI12843.1 .
BC036504 mRNA. Translation: AAH36504.3 .
CCDSi CCDS35169.1. [Q8NE28-1 ]
RefSeqi NP_714921.4. NM_153710.4.
UniGenei Hs.720195.

3D structure databases

ProteinModelPortali Q8NE28.
SMRi Q8NE28. Positions 23-325.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8NE28.

Polymorphism databases

DMDMi 90111984.

Proteomic databases

PaxDbi Q8NE28.
PRIDEi Q8NE28.

Protocols and materials databases

DNASUi 169436.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371955 ; ENSP00000361023 ; ENSG00000198870 . [Q8NE28-2 ]
ENST00000371957 ; ENSP00000361025 ; ENSG00000198870 . [Q8NE28-1 ]
ENST00000570203 ; ENSP00000454291 ; ENSG00000260489 .
GeneIDi 169436.
KEGGi hsa:169436.
UCSCi uc004cdk.3. human. [Q8NE28-1 ]

Organism-specific databases

CTDi 169436.
GeneCardsi GC09P136243.
H-InvDB HIX0034803.
HIX0035032.
HGNCi HGNC:28669. STKLD1.
HPAi HPA029902.
neXtProti NX_Q8NE28.
PharmGKBi PA134891744.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000054200.
HOVERGENi HBG056774.
InParanoidi Q8NE28.
KOi K17546.
OMAi NCINCKH.
PhylomeDBi Q8NE28.
TreeFami TF336364.

Enzyme and pathway databases

SignaLinki Q8NE28.

Miscellaneous databases

ChiTaRSi C9orf96. human.
GenomeRNAii 169436.
NextBioi 88811.
PROi Q8NE28.

Gene expression databases

ArrayExpressi Q8NE28.
Bgeei Q8NE28.
Genevestigatori Q8NE28.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Amygdala and Thalamus.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-473.
    Tissue: Testis.
  4. Cited for: IDENTIFICATION.
  5. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-139.

Entry informationi

Entry nameiSTKL1_HUMAN
AccessioniPrimary (citable) accession number: Q8NE28
Secondary accession number(s): Q5T8U8, Q6ZMP6, Q6ZMQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: September 3, 2014
This is version 111 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Asn-157 is present instead of the conserved Asp which is expected to be an active site residue.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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