Q8NE26 (Q8NE26_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
ADAM metallopeptidase with thrombospondin type 1 motif, 1 EMBL AAH36515.1

Gene names

Name:

ADAMTS1 EMBL AAH36515.1

Organism

Homo sapiens (Human) EMBL AAH36515.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	967 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 peptidase M12B domain. RuleBase RU004141 SAAS SAAS002870

Ontologies

Keywords
Cellular component	Secreted SAAS SAAS001590
PTM	Disulfide bond SAAS SAAS002870
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8NE26 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: FF1D399674201C3D	FASTA	967	105,388
	10 20 30 40 50 60 MQRAVPEGFG RRKLGSDMGN AERAPGSRSF GPVPTLLLLA AALLAVSDAL GRPSEEDEEL 70 80 90 100 110 120 VVPELERAPG HGTTRLRLHA FDQQLDLELR PDSSFLAPGF TLQNVGRKSG SETPLPETDL 130 140 150 160 170 180 AHCFYSGTVN GDPSSAAALS LCEGVRGAFY LLGEAYFIQP LPAASERLAT AAPGEKPPAP 190 200 210 220 230 240 LQFHLLRRNR QGDVGGTCGV VDDEPRPTGK AETEDEDEGT EGEDEGPQWS PQDPALQGVG 250 260 270 280 290 300 QPTGTGSIRK KRFVSSHRYV ETMLVADQSM AEFHGSGLKH YLLTLFSVAA RLYKHPSIRN 310 320 330 340 350 360 SVSLVVVKIL VIHDEQKGPE VTSNAALTLR NFCNWQKQHN PPSDRDAEHY DTAILFTRQD 370 380 390 400 410 420 LCGSQTCDTL GMADVGTVCD PSRSCSVIED DGLQAAFTTA HELGHVFNMP HDDAKQCASL 430 440 450 460 470 480 NGVNQDSHMM ASMLSNLDHS QPWSPCSAYM ITSFLDNGHG ECLMDKPQNP IQLPGDLPGT 490 500 510 520 530 540 SYDANRQCQF TFGEDSKHCP DAASTCSTLW CTGTSGGVLV CQTKHFPWAD GTSCGEGKWC 550 560 570 580 590 600 INGKCVNKTD RKHFDTPFHG SWGMWGPWGD CSRTCGGGVQ YTMRECDNPV PKNGGKYCEG 610 620 630 640 650 660 KRVRYRSCNL EDCPDNNGKT FREEQCEAHN EFSKASFGSG PAVEWIPKYA GVSPKDRCKL 670 680 690 700 710 720 ICQAKGIGYF FVLQPKVVDG TPCSTDSTSV CVQGQCVKAG CDRIIDSKKK FDKCGVCGGN 730 740 750 760 770 780 GSTCKKISGS VTSAKPGYHD IITIPTGATN IEVKQRNQRG SRNNGSFLAI KAADGTYILN 790 800 810 820 830 840 GDYTLSTLEQ DIMYKGVVLR YSGSSAALER IRSFSPLKEP LTIQVLTVGN ALRPKIKYTY 850 860 870 880 890 900 FVKKKKESFN AIPTFSAWVI EEWGECSKSC ELGWQRRLVE CRDINGQPAS ECAKEVKPAS 910 920 930 940 950 960 TRPCADHPCP QWQLGEWSSC SKTCGKGYKK RSLKCLSHDG GVLSHESCDP LKKPKHFIDF CTMAECS

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis EMBL AAH36515.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC036515 mRNA. Translation: AAH36515.1.
IPI	IPI00005908.
RefSeq	NP_008919.3. NM_006988.3.
UniGene	Hs.643357.
3D structure databases
HSSP	HSSP built from PDB template 1LSL based on UniProtKB P07996.
ProteinModelPortal	Q8NE26.
SMR	Q8NE26. Positions 256-548.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NE26.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9510.
KEGG	hsa:9510.
Organism-specific databases
CTD	9510.
PharmGKB	PA24536.
Phylogenomic databases
HOVERGEN	HBG004313.
Gene expression databases
ArrayExpress	Q8NE26.
Family and domain databases
InterPro	IPR006586. ADAM_Cys-rich. IPR010294. ADAM_spacer1. IPR024079. MetalloPept_cat_dom. IPR013274. Pept_M12B_ADAM-TS1. IPR001590. Peptidase_M12B. IPR013273. Peptidase_M12B_ADAM-TS. IPR002870. Peptidase_M12B_N. IPR000884. Thrombospondin_1_rpt. [Graphical view]
Gene3D	G3DSA:3.40.390.10. G3DSA:3.40.390.10. 1 hit.
KO	K08617.
Pfam	PF05986. ADAM_spacer1. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. PF00090. TSP_1. 3 hits. [Graphical view]
PRINTS	PR01858. ADAMTS1. PR01857. ADAMTSFAMILY.
SMART	SM00608. ACR. 1 hit. SM00209. TSP1. 3 hits. [Graphical view]
SUPFAM	SSF82895. TSP1. 3 hits.
PROSITE	PS50215. ADAM_MEPRO. 1 hit. PS50092. TSP1. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	35638.

Entry information

Entry name

Q8NE26_HUMAN

Accession

Primary (citable) accession number: Q8NE26

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.