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Q8NE09

- RGS22_HUMAN

UniProt

Q8NE09 - RGS22_HUMAN

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Protein

Regulator of G-protein signaling 22

Gene

RGS22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.By similarity

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome

GO - Biological processi

  1. positive regulation of GTPase activity Source: GOC
  2. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 22
Short name:
RGS22
Gene namesi
Name:RGS22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:24499. RGS22.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication
Note: Expressed in the cytoplasm of spermatogonia and spermatocytes. In spermatids, also expressed in the nucleus.

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. nucleus Source: UniProtKB-KW
  3. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671068.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12641264Regulator of G-protein signaling 22PRO_0000271376Add
BLAST

Proteomic databases

PaxDbiQ8NE09.
PRIDEiQ8NE09.

PTM databases

PhosphoSiteiQ8NE09.

Expressioni

Tissue specificityi

Testis-specific. Expressed in Leydig cells and spermatogenic cells from the spermatogonia to spermatid stages (at protein level).1 Publication

Gene expression databases

BgeeiQ8NE09.
CleanExiHS_RGS22.
ExpressionAtlasiQ8NE09. baseline and differential.
GenevestigatoriQ8NE09.

Organism-specific databases

HPAiHPA023118.

Interactioni

Subunit structurei

Interacts with GNA11, GNA12 AND GNA13.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000354109.

Structurei

3D structure databases

ProteinModelPortaliQ8NE09.
SMRiQ8NE09. Positions 853-975.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini852 – 980129RGS 1PROSITE-ProRule annotationAdd
BLAST
Domaini1021 – 1145125RGS 2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1142 – 117433Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi267 – 27711Poly-GluAdd
BLAST
Compositional biasi767 – 7715Poly-Leu

Sequence similaritiesi

Contains 2 RGS domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG40652.
GeneTreeiENSGT00500000044936.
HOGENOMiHOG000013183.
HOVERGENiHBG054528.
InParanoidiQ8NE09.
OMAiWAPRFCV.
OrthoDBiEOG7SN8CM.
PhylomeDBiQ8NE09.
TreeFamiTF329128.

Family and domain databases

InterProiIPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 3 hits.
[Graphical view]
SMARTiSM00315. RGS. 2 hits.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 4 hits.
PROSITEiPS50132. RGS. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NE09-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEKRLTAEP PTITEEEFED SLATDDFLVD YFNEFLSLPT FSEAIRFNAD
60 70 80 90 100
YGVFEVANDA PQFLEKQLKK ILQNQQPRNP IYDVVRKGKN EVKPVQMNAP
110 120 130 140 150
DEDETINVNY NIMCLSREEG IKWIKKERLP AFLESDCYFE YRLAKLVSQV
160 170 180 190 200
RWSKSGMNFT VGSNFSPWIV KKPPSLPPPA TEEDNLVIMK KFYVSLGEAS
210 220 230 240 250
YTQTKDWFAL AKQSQQTVST FSLPCCVPYN KLKSPAISSV SENFIFDDGV
260 270 280 290 300
HPRTKKDPSK TNKLISEFEE EEGEEEEVSV SLQDTPSQAL LRVYLEKKQD
310 320 330 340 350
VDESLTMHFS TCEEFLSSYI YFILRGAIQQ IVGKPVGETP DYINFNNITK
360 370 380 390 400
VSFDDCFESI HGKNFLSELV QTTKERSEEI EQTSLSSKNE SAGPESRADW
410 420 430 440 450
CISHRTYDIG NRKEFERFKK FIKGTLGERY WWLWMDIERL KVLKDPGRHQ
460 470 480 490 500
RHLEKMKKCY LVSNGDYYLS AEILSKFKLL DGSQWNEEHL RNIQSEVLKP
510 520 530 540 550
LLLYWAPRFC VTHSASTKYA SAELKFWHLR QAKPRKDIDP FPQMATLLPL
560 570 580 590 600
RPKSCIPQIP EIQKEEFSLS QPPKSPNKSP EVKTATQKPW KRELLYPGSS
610 620 630 640 650
KDDVIEKGSK YMSESSKVIH LTSFTDISEC LKPQLDRRYA YTEEPRVKTV
660 670 680 690 700
SDVGALGGSD MENLLQSLYV ENRAGFFFTK FCEHSGNKLW KNSVYFWFDL
710 720 730 740 750
QAYHQLFYQE TLQPFKVCKQ AQYLFATYVA PSATLDIGLQ QEKKKEIYMK
760 770 780 790 800
IQPPFEDLFD TAEEYILLLL LEPWTKMVKS DQIAYKKVEL VEETRQLDST
810 820 830 840 850
YFRKLQALHK ETFSKKAEDT TCEIGTGILS LSNVSKRTEY WDNVPAEYKH
860 870 880 890 900
FKFSDLLNNK LEFEHFRQFL ETHSSSMDLM CWTDIEQFRR ITYRDRNQRK
910 920 930 940 950
AKSIYIKNKY LNKKYFFGPN SPASLYQQNQ VMHLSGGWGK ILHEQLDAPV
960 970 980 990 1000
LVEIQKHVQN RLENVWLPLF LASEQFAARQ KIKVQMKDIA EELLLQKAEK
1010 1020 1030 1040 1050
KIGVWKPVES KWISSSCKII AFRKALLNPV TSRQFQRFVA LKGDLLENGL
1060 1070 1080 1090 1100
LFWQEVQKYK DLCHSHCDES VIQKKITTII NCFINSSIPP ALQIDIPVEQ
1110 1120 1130 1140 1150
AQKIIEHRKE LGPYVFREAQ MTIFGVLFKF WPQFCEFRKN LTDENIMSVL
1160 1170 1180 1190 1200
ERRQEYNKQK KKLAVLEDEK SGKDGIKQYA NTSVPAIKTA LLSDSFLGLQ
1210 1220 1230 1240 1250
PYGRQPTWCY SKYIEALEQE RILLKIQEEL EKKLFAGLQP LTNFKASSST
1260
MSLKKNMSAH SSQK
Length:1,264
Mass (Da):147,163
Last modified:January 9, 2007 - v3
Checksum:i8647E53FE14B9D5D
GO
Isoform 2 (identifier: Q8NE09-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-1264: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:504
Mass (Da):58,519
Checksum:iEB2E679C9E730552
GO
Isoform 3 (identifier: Q8NE09-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-198: Missing.

Note: May be due to competing donor splice site.

Show »
Length:1,252
Mass (Da):145,768
Checksum:iA7CB6BFD5C6F2E6E
GO

Sequence cautioni

The sequence AAG49397.1 differs from that shown. Reason: Frameshift at positions 877, 882, 886 and 891. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti86 – 861Missing in AAH92411. (PubMed:15489334)Curated
Sequence conflicti131 – 1311A → P in AAH47060. (PubMed:15489334)Curated
Sequence conflicti167 – 1671P → S in AAG49397. (PubMed:18703424)Curated
Sequence conflicti378 – 3781E → K in AAH36665. (PubMed:15489334)Curated
Sequence conflicti423 – 4231K → R in AAG49397. (PubMed:18703424)Curated
Sequence conflicti692 – 6921N → D in AAG49397. (PubMed:18703424)Curated
Sequence conflicti995 – 9973LQK → DAW in CAB55986. (PubMed:17974005)Curated
Sequence conflicti1070 – 10701S → T in AAG49397. (PubMed:18703424)Curated
Sequence conflicti1233 – 12331K → KK in CAB55986. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti397 – 3971R → M.
Corresponds to variant rs2446927 [ dbSNP | Ensembl ].
VAR_051797
Natural varianti943 – 9431H → Y.
Corresponds to variant rs3133711 [ dbSNP | Ensembl ].
VAR_051798

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei187 – 19812Missing in isoform 3. 2 PublicationsVSP_054225Add
BLAST
Alternative sequencei505 – 1264760Missing in isoform 2. 1 PublicationVSP_022306Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009106 mRNA. Translation: AAG49397.1. Frameshift.
AK292559 mRNA. Translation: BAF85248.1.
AC021590 Genomic DNA. No translation available.
AP005356 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91794.1.
BC036665 mRNA. Translation: AAH36665.2.
BC047060 mRNA. Translation: AAH47060.1.
BC092411 mRNA. Translation: AAH92411.1.
AL117544 mRNA. Translation: CAB55986.2.
CCDSiCCDS43758.1. [Q8NE09-1]
CCDS69521.1. [Q8NE09-3]
PIRiT17296.
RefSeqiNP_001273621.1. NM_001286692.1. [Q8NE09-3]
NP_056483.3. NM_015668.4. [Q8NE09-1]
UniGeneiHs.120021.

Genome annotation databases

EnsembliENST00000360863; ENSP00000354109; ENSG00000132554. [Q8NE09-1]
ENST00000519725; ENSP00000427798; ENSG00000132554. [Q8NE09-2]
ENST00000523437; ENSP00000428212; ENSG00000132554. [Q8NE09-3]
GeneIDi26166.
KEGGihsa:26166.
UCSCiuc003yjb.1. human. [Q8NE09-1]
uc003yjc.1. human.

Polymorphism databases

DMDMi122064954.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009106 mRNA. Translation: AAG49397.1 . Frameshift.
AK292559 mRNA. Translation: BAF85248.1 .
AC021590 Genomic DNA. No translation available.
AP005356 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91794.1 .
BC036665 mRNA. Translation: AAH36665.2 .
BC047060 mRNA. Translation: AAH47060.1 .
BC092411 mRNA. Translation: AAH92411.1 .
AL117544 mRNA. Translation: CAB55986.2 .
CCDSi CCDS43758.1. [Q8NE09-1 ]
CCDS69521.1. [Q8NE09-3 ]
PIRi T17296.
RefSeqi NP_001273621.1. NM_001286692.1. [Q8NE09-3 ]
NP_056483.3. NM_015668.4. [Q8NE09-1 ]
UniGenei Hs.120021.

3D structure databases

ProteinModelPortali Q8NE09.
SMRi Q8NE09. Positions 853-975.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000354109.

PTM databases

PhosphoSitei Q8NE09.

Polymorphism databases

DMDMi 122064954.

Proteomic databases

PaxDbi Q8NE09.
PRIDEi Q8NE09.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360863 ; ENSP00000354109 ; ENSG00000132554 . [Q8NE09-1 ]
ENST00000519725 ; ENSP00000427798 ; ENSG00000132554 . [Q8NE09-2 ]
ENST00000523437 ; ENSP00000428212 ; ENSG00000132554 . [Q8NE09-3 ]
GeneIDi 26166.
KEGGi hsa:26166.
UCSCi uc003yjb.1. human. [Q8NE09-1 ]
uc003yjc.1. human.

Organism-specific databases

CTDi 26166.
GeneCardsi GC08M100973.
H-InvDB HIX0019311.
HGNCi HGNC:24499. RGS22.
HPAi HPA023118.
MIMi 615650. gene.
neXtProti NX_Q8NE09.
PharmGKBi PA142671068.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40652.
GeneTreei ENSGT00500000044936.
HOGENOMi HOG000013183.
HOVERGENi HBG054528.
InParanoidi Q8NE09.
OMAi WAPRFCV.
OrthoDBi EOG7SN8CM.
PhylomeDBi Q8NE09.
TreeFami TF329128.

Miscellaneous databases

ChiTaRSi RGS22. human.
GenomeRNAii 26166.
NextBioi 35464609.
PROi Q8NE09.
SOURCEi Search...

Gene expression databases

Bgeei Q8NE09.
CleanExi HS_RGS22.
ExpressionAtlasi Q8NE09. baseline and differential.
Genevestigatori Q8NE09.

Family and domain databases

InterProi IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 3 hits.
[Graphical view ]
SMARTi SM00315. RGS. 2 hits.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 4 hits.
PROSITEi PS50132. RGS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits."
    Hu Y., Xing J., Chen L., Guo X., Du Y., Zhao C., Zhu Y., Lin M., Zhou Z., Sha J.
    Biol. Reprod. 79:1021-1029(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), INTERACTION WITH GNA11; GNA12 AND GNA13, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 995-1264 (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiRGS22_HUMAN
AccessioniPrimary (citable) accession number: Q8NE09
Secondary accession number(s): A8K944
, Q569L2, Q86Y71, Q9BYZ4, Q9UFN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3