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Q8NE09

- RGS22_HUMAN

UniProt

Q8NE09 - RGS22_HUMAN

Protein

Regulator of G-protein signaling 22

Gene

RGS22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 22
    Short name:
    RGS22
    Gene namesi
    Name:RGS22
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:24499. RGS22.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Expressed in the cytoplasm of spermatogonia and spermatocytes. In spermatids, also expressed in the nucleus.

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. nucleus Source: UniProtKB-SubCell
    3. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671068.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12641264Regulator of G-protein signaling 22PRO_0000271376Add
    BLAST

    Proteomic databases

    PaxDbiQ8NE09.
    PRIDEiQ8NE09.

    PTM databases

    PhosphoSiteiQ8NE09.

    Expressioni

    Tissue specificityi

    Testis-specific. Expressed in Leydig cells and spermatogenic cells from the spermatogonia to spermatid stages (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ8NE09.
    BgeeiQ8NE09.
    CleanExiHS_RGS22.
    GenevestigatoriQ8NE09.

    Organism-specific databases

    HPAiHPA023118.

    Interactioni

    Subunit structurei

    Interacts with GNA11, GNA12 AND GNA13.1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000354109.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NE09.
    SMRiQ8NE09. Positions 853-975.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini852 – 980129RGS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1021 – 1145125RGS 2PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1142 – 117433Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi267 – 27711Poly-GluAdd
    BLAST
    Compositional biasi767 – 7715Poly-Leu

    Sequence similaritiesi

    Contains 2 RGS domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG40652.
    HOGENOMiHOG000013183.
    HOVERGENiHBG054528.
    InParanoidiQ8NE09.
    OMAiWAPRFCV.
    OrthoDBiEOG7SN8CM.
    PhylomeDBiQ8NE09.
    TreeFamiTF329128.

    Family and domain databases

    InterProiIPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 3 hits.
    [Graphical view]
    SMARTiSM00315. RGS. 2 hits.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 4 hits.
    PROSITEiPS50132. RGS. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NE09-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPEKRLTAEP PTITEEEFED SLATDDFLVD YFNEFLSLPT FSEAIRFNAD     50
    YGVFEVANDA PQFLEKQLKK ILQNQQPRNP IYDVVRKGKN EVKPVQMNAP 100
    DEDETINVNY NIMCLSREEG IKWIKKERLP AFLESDCYFE YRLAKLVSQV 150
    RWSKSGMNFT VGSNFSPWIV KKPPSLPPPA TEEDNLVIMK KFYVSLGEAS 200
    YTQTKDWFAL AKQSQQTVST FSLPCCVPYN KLKSPAISSV SENFIFDDGV 250
    HPRTKKDPSK TNKLISEFEE EEGEEEEVSV SLQDTPSQAL LRVYLEKKQD 300
    VDESLTMHFS TCEEFLSSYI YFILRGAIQQ IVGKPVGETP DYINFNNITK 350
    VSFDDCFESI HGKNFLSELV QTTKERSEEI EQTSLSSKNE SAGPESRADW 400
    CISHRTYDIG NRKEFERFKK FIKGTLGERY WWLWMDIERL KVLKDPGRHQ 450
    RHLEKMKKCY LVSNGDYYLS AEILSKFKLL DGSQWNEEHL RNIQSEVLKP 500
    LLLYWAPRFC VTHSASTKYA SAELKFWHLR QAKPRKDIDP FPQMATLLPL 550
    RPKSCIPQIP EIQKEEFSLS QPPKSPNKSP EVKTATQKPW KRELLYPGSS 600
    KDDVIEKGSK YMSESSKVIH LTSFTDISEC LKPQLDRRYA YTEEPRVKTV 650
    SDVGALGGSD MENLLQSLYV ENRAGFFFTK FCEHSGNKLW KNSVYFWFDL 700
    QAYHQLFYQE TLQPFKVCKQ AQYLFATYVA PSATLDIGLQ QEKKKEIYMK 750
    IQPPFEDLFD TAEEYILLLL LEPWTKMVKS DQIAYKKVEL VEETRQLDST 800
    YFRKLQALHK ETFSKKAEDT TCEIGTGILS LSNVSKRTEY WDNVPAEYKH 850
    FKFSDLLNNK LEFEHFRQFL ETHSSSMDLM CWTDIEQFRR ITYRDRNQRK 900
    AKSIYIKNKY LNKKYFFGPN SPASLYQQNQ VMHLSGGWGK ILHEQLDAPV 950
    LVEIQKHVQN RLENVWLPLF LASEQFAARQ KIKVQMKDIA EELLLQKAEK 1000
    KIGVWKPVES KWISSSCKII AFRKALLNPV TSRQFQRFVA LKGDLLENGL 1050
    LFWQEVQKYK DLCHSHCDES VIQKKITTII NCFINSSIPP ALQIDIPVEQ 1100
    AQKIIEHRKE LGPYVFREAQ MTIFGVLFKF WPQFCEFRKN LTDENIMSVL 1150
    ERRQEYNKQK KKLAVLEDEK SGKDGIKQYA NTSVPAIKTA LLSDSFLGLQ 1200
    PYGRQPTWCY SKYIEALEQE RILLKIQEEL EKKLFAGLQP LTNFKASSST 1250
    MSLKKNMSAH SSQK 1264
    Length:1,264
    Mass (Da):147,163
    Last modified:January 9, 2007 - v3
    Checksum:i8647E53FE14B9D5D
    GO
    Isoform 2 (identifier: Q8NE09-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         505-1264: Missing.

    Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:504
    Mass (Da):58,519
    Checksum:iEB2E679C9E730552
    GO
    Isoform 3 (identifier: Q8NE09-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         187-198: Missing.

    Note: May be due to competing donor splice site.

    Show »
    Length:1,252
    Mass (Da):145,768
    Checksum:iA7CB6BFD5C6F2E6E
    GO

    Sequence cautioni

    The sequence AAG49397.1 differs from that shown. Reason: Frameshift at positions 877, 882, 886 and 891.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti86 – 861Missing in AAH92411. (PubMed:15489334)Curated
    Sequence conflicti131 – 1311A → P in AAH47060. (PubMed:15489334)Curated
    Sequence conflicti167 – 1671P → S in AAG49397. (PubMed:18703424)Curated
    Sequence conflicti378 – 3781E → K in AAH36665. (PubMed:15489334)Curated
    Sequence conflicti423 – 4231K → R in AAG49397. (PubMed:18703424)Curated
    Sequence conflicti692 – 6921N → D in AAG49397. (PubMed:18703424)Curated
    Sequence conflicti995 – 9973LQK → DAW in CAB55986. (PubMed:17974005)Curated
    Sequence conflicti1070 – 10701S → T in AAG49397. (PubMed:18703424)Curated
    Sequence conflicti1233 – 12331K → KK in CAB55986. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti397 – 3971R → M.
    Corresponds to variant rs2446927 [ dbSNP | Ensembl ].
    VAR_051797
    Natural varianti943 – 9431H → Y.
    Corresponds to variant rs3133711 [ dbSNP | Ensembl ].
    VAR_051798

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei187 – 19812Missing in isoform 3. 2 PublicationsVSP_054225Add
    BLAST
    Alternative sequencei505 – 1264760Missing in isoform 2. 1 PublicationVSP_022306Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY009106 mRNA. Translation: AAG49397.1. Frameshift.
    AK292559 mRNA. Translation: BAF85248.1.
    AC021590 Genomic DNA. No translation available.
    AP005356 Genomic DNA. No translation available.
    CH471060 Genomic DNA. Translation: EAW91794.1.
    BC036665 mRNA. Translation: AAH36665.2.
    BC047060 mRNA. Translation: AAH47060.1.
    BC092411 mRNA. Translation: AAH92411.1.
    AL117544 mRNA. Translation: CAB55986.2.
    CCDSiCCDS43758.1. [Q8NE09-1]
    CCDS69521.1. [Q8NE09-3]
    PIRiT17296.
    RefSeqiNP_001273621.1. NM_001286692.1. [Q8NE09-3]
    NP_056483.3. NM_015668.4. [Q8NE09-1]
    UniGeneiHs.120021.

    Genome annotation databases

    EnsembliENST00000360863; ENSP00000354109; ENSG00000132554. [Q8NE09-1]
    ENST00000519725; ENSP00000427798; ENSG00000132554. [Q8NE09-2]
    ENST00000523437; ENSP00000428212; ENSG00000132554. [Q8NE09-3]
    GeneIDi26166.
    KEGGihsa:26166.
    UCSCiuc003yjb.1. human. [Q8NE09-1]
    uc003yjc.1. human.

    Polymorphism databases

    DMDMi122064954.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY009106 mRNA. Translation: AAG49397.1 . Frameshift.
    AK292559 mRNA. Translation: BAF85248.1 .
    AC021590 Genomic DNA. No translation available.
    AP005356 Genomic DNA. No translation available.
    CH471060 Genomic DNA. Translation: EAW91794.1 .
    BC036665 mRNA. Translation: AAH36665.2 .
    BC047060 mRNA. Translation: AAH47060.1 .
    BC092411 mRNA. Translation: AAH92411.1 .
    AL117544 mRNA. Translation: CAB55986.2 .
    CCDSi CCDS43758.1. [Q8NE09-1 ]
    CCDS69521.1. [Q8NE09-3 ]
    PIRi T17296.
    RefSeqi NP_001273621.1. NM_001286692.1. [Q8NE09-3 ]
    NP_056483.3. NM_015668.4. [Q8NE09-1 ]
    UniGenei Hs.120021.

    3D structure databases

    ProteinModelPortali Q8NE09.
    SMRi Q8NE09. Positions 853-975.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000354109.

    PTM databases

    PhosphoSitei Q8NE09.

    Polymorphism databases

    DMDMi 122064954.

    Proteomic databases

    PaxDbi Q8NE09.
    PRIDEi Q8NE09.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360863 ; ENSP00000354109 ; ENSG00000132554 . [Q8NE09-1 ]
    ENST00000519725 ; ENSP00000427798 ; ENSG00000132554 . [Q8NE09-2 ]
    ENST00000523437 ; ENSP00000428212 ; ENSG00000132554 . [Q8NE09-3 ]
    GeneIDi 26166.
    KEGGi hsa:26166.
    UCSCi uc003yjb.1. human. [Q8NE09-1 ]
    uc003yjc.1. human.

    Organism-specific databases

    CTDi 26166.
    GeneCardsi GC08M100973.
    H-InvDB HIX0019311.
    HGNCi HGNC:24499. RGS22.
    HPAi HPA023118.
    MIMi 615650. gene.
    neXtProti NX_Q8NE09.
    PharmGKBi PA142671068.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40652.
    HOGENOMi HOG000013183.
    HOVERGENi HBG054528.
    InParanoidi Q8NE09.
    OMAi WAPRFCV.
    OrthoDBi EOG7SN8CM.
    PhylomeDBi Q8NE09.
    TreeFami TF329128.

    Miscellaneous databases

    ChiTaRSi RGS22. human.
    GenomeRNAii 26166.
    NextBioi 35464609.
    PROi Q8NE09.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NE09.
    Bgeei Q8NE09.
    CleanExi HS_RGS22.
    Genevestigatori Q8NE09.

    Family and domain databases

    InterProi IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 3 hits.
    [Graphical view ]
    SMARTi SM00315. RGS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 4 hits.
    PROSITEi PS50132. RGS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits."
      Hu Y., Xing J., Chen L., Guo X., Du Y., Zhao C., Zhu Y., Lin M., Zhou Z., Sha J.
      Biol. Reprod. 79:1021-1029(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), INTERACTION WITH GNA11; GNA12 AND GNA13, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Testis.
    3. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Testis.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 995-1264 (ISOFORM 1).
      Tissue: Testis.

    Entry informationi

    Entry nameiRGS22_HUMAN
    AccessioniPrimary (citable) accession number: Q8NE09
    Secondary accession number(s): A8K944
    , Q569L2, Q86Y71, Q9BYZ4, Q9UFN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3