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Protein

Regulator of G-protein signaling 22

Gene

RGS22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 22
Short name:
RGS22
Gene namesi
Name:RGS22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:24499. RGS22.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

  • Note: Expressed in the cytoplasm of spermatogonia and spermatocytes. In spermatids, also expressed in the nucleus.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26166.
OpenTargetsiENSG00000132554.
PharmGKBiPA142671068.

Polymorphism and mutation databases

BioMutaiRGS22.
DMDMi122064954.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002713761 – 1264Regulator of G-protein signaling 22Add BLAST1264

Proteomic databases

EPDiQ8NE09.
MaxQBiQ8NE09.
PaxDbiQ8NE09.
PeptideAtlasiQ8NE09.
PRIDEiQ8NE09.

PTM databases

iPTMnetiQ8NE09.
PhosphoSitePlusiQ8NE09.

Expressioni

Tissue specificityi

Testis-specific. Expressed in Leydig cells and spermatogenic cells from the spermatogonia to spermatid stages (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000132554.
CleanExiHS_RGS22.
ExpressionAtlasiQ8NE09. baseline and differential.
GenevisibleiQ8NE09. HS.

Organism-specific databases

HPAiHPA023118.
HPA053026.

Interactioni

Subunit structurei

Interacts with GNA11, GNA12 AND GNA13.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000354109.

Structurei

3D structure databases

ProteinModelPortaliQ8NE09.
SMRiQ8NE09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini852 – 980RGS 1PROSITE-ProRule annotationAdd BLAST129
Domaini1021 – 1145RGS 2PROSITE-ProRule annotationAdd BLAST125

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1142 – 1174Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi267 – 277Poly-GluAdd BLAST11
Compositional biasi767 – 771Poly-Leu5

Sequence similaritiesi

Contains 2 RGS domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IEHZ. Eukaryota.
ENOG410XTGI. LUCA.
GeneTreeiENSGT00500000044936.
HOGENOMiHOG000013183.
HOVERGENiHBG054528.
InParanoidiQ8NE09.
OMAiNQQPRNP.
OrthoDBiEOG091G0RK5.
PhylomeDBiQ8NE09.
TreeFamiTF329128.

Family and domain databases

InterProiIPR016137. RGS.
[Graphical view]
PfamiPF00615. RGS. 3 hits.
[Graphical view]
SMARTiSM00315. RGS. 2 hits.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 4 hits.
PROSITEiPS50132. RGS. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NE09-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEKRLTAEP PTITEEEFED SLATDDFLVD YFNEFLSLPT FSEAIRFNAD
60 70 80 90 100
YGVFEVANDA PQFLEKQLKK ILQNQQPRNP IYDVVRKGKN EVKPVQMNAP
110 120 130 140 150
DEDETINVNY NIMCLSREEG IKWIKKERLP AFLESDCYFE YRLAKLVSQV
160 170 180 190 200
RWSKSGMNFT VGSNFSPWIV KKPPSLPPPA TEEDNLVIMK KFYVSLGEAS
210 220 230 240 250
YTQTKDWFAL AKQSQQTVST FSLPCCVPYN KLKSPAISSV SENFIFDDGV
260 270 280 290 300
HPRTKKDPSK TNKLISEFEE EEGEEEEVSV SLQDTPSQAL LRVYLEKKQD
310 320 330 340 350
VDESLTMHFS TCEEFLSSYI YFILRGAIQQ IVGKPVGETP DYINFNNITK
360 370 380 390 400
VSFDDCFESI HGKNFLSELV QTTKERSEEI EQTSLSSKNE SAGPESRADW
410 420 430 440 450
CISHRTYDIG NRKEFERFKK FIKGTLGERY WWLWMDIERL KVLKDPGRHQ
460 470 480 490 500
RHLEKMKKCY LVSNGDYYLS AEILSKFKLL DGSQWNEEHL RNIQSEVLKP
510 520 530 540 550
LLLYWAPRFC VTHSASTKYA SAELKFWHLR QAKPRKDIDP FPQMATLLPL
560 570 580 590 600
RPKSCIPQIP EIQKEEFSLS QPPKSPNKSP EVKTATQKPW KRELLYPGSS
610 620 630 640 650
KDDVIEKGSK YMSESSKVIH LTSFTDISEC LKPQLDRRYA YTEEPRVKTV
660 670 680 690 700
SDVGALGGSD MENLLQSLYV ENRAGFFFTK FCEHSGNKLW KNSVYFWFDL
710 720 730 740 750
QAYHQLFYQE TLQPFKVCKQ AQYLFATYVA PSATLDIGLQ QEKKKEIYMK
760 770 780 790 800
IQPPFEDLFD TAEEYILLLL LEPWTKMVKS DQIAYKKVEL VEETRQLDST
810 820 830 840 850
YFRKLQALHK ETFSKKAEDT TCEIGTGILS LSNVSKRTEY WDNVPAEYKH
860 870 880 890 900
FKFSDLLNNK LEFEHFRQFL ETHSSSMDLM CWTDIEQFRR ITYRDRNQRK
910 920 930 940 950
AKSIYIKNKY LNKKYFFGPN SPASLYQQNQ VMHLSGGWGK ILHEQLDAPV
960 970 980 990 1000
LVEIQKHVQN RLENVWLPLF LASEQFAARQ KIKVQMKDIA EELLLQKAEK
1010 1020 1030 1040 1050
KIGVWKPVES KWISSSCKII AFRKALLNPV TSRQFQRFVA LKGDLLENGL
1060 1070 1080 1090 1100
LFWQEVQKYK DLCHSHCDES VIQKKITTII NCFINSSIPP ALQIDIPVEQ
1110 1120 1130 1140 1150
AQKIIEHRKE LGPYVFREAQ MTIFGVLFKF WPQFCEFRKN LTDENIMSVL
1160 1170 1180 1190 1200
ERRQEYNKQK KKLAVLEDEK SGKDGIKQYA NTSVPAIKTA LLSDSFLGLQ
1210 1220 1230 1240 1250
PYGRQPTWCY SKYIEALEQE RILLKIQEEL EKKLFAGLQP LTNFKASSST
1260
MSLKKNMSAH SSQK
Length:1,264
Mass (Da):147,163
Last modified:January 9, 2007 - v3
Checksum:i8647E53FE14B9D5D
GO
Isoform 2 (identifier: Q8NE09-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-1264: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:504
Mass (Da):58,519
Checksum:iEB2E679C9E730552
GO
Isoform 3 (identifier: Q8NE09-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-198: Missing.

Note: May be due to competing donor splice site.
Show »
Length:1,252
Mass (Da):145,768
Checksum:iA7CB6BFD5C6F2E6E
GO

Sequence cautioni

The sequence AAG49397 differs from that shown. Reason: Frameshift at positions 877, 882, 886 and 891.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86Missing in AAH92411 (PubMed:15489334).Curated1
Sequence conflicti131A → P in AAH47060 (PubMed:15489334).Curated1
Sequence conflicti167P → S in AAG49397 (PubMed:18703424).Curated1
Sequence conflicti378E → K in AAH36665 (PubMed:15489334).Curated1
Sequence conflicti423K → R in AAG49397 (PubMed:18703424).Curated1
Sequence conflicti692N → D in AAG49397 (PubMed:18703424).Curated1
Sequence conflicti995 – 997LQK → DAW in CAB55986 (PubMed:17974005).Curated3
Sequence conflicti1070S → T in AAG49397 (PubMed:18703424).Curated1
Sequence conflicti1233K → KK in CAB55986 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051797397R → M.Corresponds to variant rs2446927dbSNPEnsembl.1
Natural variantiVAR_051798943H → Y.Corresponds to variant rs3133711dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054225187 – 198Missing in isoform 3. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_022306505 – 1264Missing in isoform 2. 1 PublicationAdd BLAST760

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009106 mRNA. Translation: AAG49397.1. Frameshift.
AK292559 mRNA. Translation: BAF85248.1.
AC021590 Genomic DNA. No translation available.
AP005356 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91794.1.
BC036665 mRNA. Translation: AAH36665.2.
BC047060 mRNA. Translation: AAH47060.1.
BC092411 mRNA. Translation: AAH92411.1.
AL117544 mRNA. Translation: CAB55986.2.
CCDSiCCDS43758.1. [Q8NE09-1]
CCDS69521.1. [Q8NE09-3]
PIRiT17296.
RefSeqiNP_001273621.1. NM_001286692.1. [Q8NE09-3]
NP_056483.3. NM_015668.4. [Q8NE09-1]
UniGeneiHs.120021.

Genome annotation databases

EnsembliENST00000360863; ENSP00000354109; ENSG00000132554. [Q8NE09-1]
ENST00000519725; ENSP00000427798; ENSG00000132554. [Q8NE09-2]
ENST00000523437; ENSP00000428212; ENSG00000132554. [Q8NE09-3]
GeneIDi26166.
KEGGihsa:26166.
UCSCiuc003yjb.2. human. [Q8NE09-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009106 mRNA. Translation: AAG49397.1. Frameshift.
AK292559 mRNA. Translation: BAF85248.1.
AC021590 Genomic DNA. No translation available.
AP005356 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91794.1.
BC036665 mRNA. Translation: AAH36665.2.
BC047060 mRNA. Translation: AAH47060.1.
BC092411 mRNA. Translation: AAH92411.1.
AL117544 mRNA. Translation: CAB55986.2.
CCDSiCCDS43758.1. [Q8NE09-1]
CCDS69521.1. [Q8NE09-3]
PIRiT17296.
RefSeqiNP_001273621.1. NM_001286692.1. [Q8NE09-3]
NP_056483.3. NM_015668.4. [Q8NE09-1]
UniGeneiHs.120021.

3D structure databases

ProteinModelPortaliQ8NE09.
SMRiQ8NE09.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354109.

PTM databases

iPTMnetiQ8NE09.
PhosphoSitePlusiQ8NE09.

Polymorphism and mutation databases

BioMutaiRGS22.
DMDMi122064954.

Proteomic databases

EPDiQ8NE09.
MaxQBiQ8NE09.
PaxDbiQ8NE09.
PeptideAtlasiQ8NE09.
PRIDEiQ8NE09.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360863; ENSP00000354109; ENSG00000132554. [Q8NE09-1]
ENST00000519725; ENSP00000427798; ENSG00000132554. [Q8NE09-2]
ENST00000523437; ENSP00000428212; ENSG00000132554. [Q8NE09-3]
GeneIDi26166.
KEGGihsa:26166.
UCSCiuc003yjb.2. human. [Q8NE09-1]

Organism-specific databases

CTDi26166.
DisGeNETi26166.
GeneCardsiRGS22.
H-InvDBHIX0019311.
HGNCiHGNC:24499. RGS22.
HPAiHPA023118.
HPA053026.
MIMi615650. gene.
neXtProtiNX_Q8NE09.
OpenTargetsiENSG00000132554.
PharmGKBiPA142671068.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEHZ. Eukaryota.
ENOG410XTGI. LUCA.
GeneTreeiENSGT00500000044936.
HOGENOMiHOG000013183.
HOVERGENiHBG054528.
InParanoidiQ8NE09.
OMAiNQQPRNP.
OrthoDBiEOG091G0RK5.
PhylomeDBiQ8NE09.
TreeFamiTF329128.

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiRGS22. human.
GenomeRNAii26166.
PROiQ8NE09.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132554.
CleanExiHS_RGS22.
ExpressionAtlasiQ8NE09. baseline and differential.
GenevisibleiQ8NE09. HS.

Family and domain databases

InterProiIPR016137. RGS.
[Graphical view]
PfamiPF00615. RGS. 3 hits.
[Graphical view]
SMARTiSM00315. RGS. 2 hits.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 4 hits.
PROSITEiPS50132. RGS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGS22_HUMAN
AccessioniPrimary (citable) accession number: Q8NE09
Secondary accession number(s): A8K944
, Q569L2, Q86Y71, Q9BYZ4, Q9UFN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.