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Protein

Transmembrane protein 104

Gene

TMEM104

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protein family/group databases

TCDBi2.A.18.10.1. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 104
Gene namesi
Name:TMEM104
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:25984. TMEM104.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Topological domaini32 – 365ExtracellularSequence Analysis
Transmembranei37 – 5721HelicalSequence AnalysisAdd
BLAST
Topological domaini58 – 14689CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Topological domaini168 – 20437ExtracellularSequence AnalysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence AnalysisAdd
BLAST
Topological domaini226 – 2338CytoplasmicSequence Analysis
Transmembranei234 – 25421HelicalSequence AnalysisAdd
BLAST
Topological domaini255 – 27622ExtracellularSequence AnalysisAdd
BLAST
Transmembranei277 – 29721HelicalSequence AnalysisAdd
BLAST
Topological domaini298 – 3069CytoplasmicSequence Analysis
Transmembranei307 – 32721HelicalSequence AnalysisAdd
BLAST
Topological domaini328 – 35427ExtracellularSequence AnalysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence AnalysisAdd
BLAST
Topological domaini376 – 39722CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei398 – 41821HelicalSequence AnalysisAdd
BLAST
Topological domaini419 – 4213ExtracellularSequence Analysis
Transmembranei422 – 44221HelicalSequence AnalysisAdd
BLAST
Topological domaini443 – 47028CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei471 – 49121HelicalSequence AnalysisAdd
BLAST
Topological domaini492 – 4965ExtracellularSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670753.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Transmembrane protein 104PRO_0000254178Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8NE00.
PaxDbiQ8NE00.
PRIDEiQ8NE00.

PTM databases

PhosphoSiteiQ8NE00.

Expressioni

Gene expression databases

BgeeiQ8NE00.
CleanExiHS_TMEM104.
ExpressionAtlasiQ8NE00. baseline and differential.
GenevestigatoriQ8NE00.

Organism-specific databases

HPAiHPA044330.

Interactioni

Protein-protein interaction databases

BioGridi120217. 3 interactions.
IntActiQ8NE00. 1 interaction.
STRINGi9606.ENSP00000334849.

Structurei

3D structure databases

ProteinModelPortaliQ8NE00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM104 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG242666.
GeneTreeiENSGT00390000001244.
HOGENOMiHOG000231060.
HOVERGENiHBG080085.
InParanoidiQ8NE00.
OMAiDSLMDMY.
PhylomeDBiQ8NE00.
TreeFamiTF314030.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NE00-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGEITETGE LYSSYVGLVY MFNLIVGTGA LTMPKAFATA GWLVSLVLLV
60 70 80 90 100
FLGFMSFVTT TFVIEAMAAA NAQLHWKRME NLKEEEDDDS STASDSDVLI
110 120 130 140 150
RDNYERAEKR PILSVQRRGS PNPFEITDRV EMGQMASMFF NKVGVNLFYF
160 170 180 190 200
CIIVYLYGDL AIYAAAVPFS LMQVTCSATG NDSCGVEADT KYNDTDRCWG
210 220 230 240 250
PLRRVDAYRI YLAIFTLLLG PFTFFDVQKT KYLQILTSLM RWIAFAVMIV
260 270 280 290 300
LALIRIGHGQ GEGHPPLADF SGVRNLFGVC VYSFMCQHSL PSLITPVSSK
310 320 330 340 350
RHLTRLVFLD YVLILAFYGL LSFTAIFCFR GDSLMDMYTL NFARCDVVGL
360 370 380 390 400
AAVRFFLGLF PVFTISTNFP IIAVTLRNNW KTLFHREGGT YPWVVDRVVF
410 420 430 440 450
PTITLVPPVL VAFCTHDLES LVGITGAYAG TGIQYVIPAF LVYHCRRDTQ
460 470 480 490
LAFGCGVSNK HRSPFRHTFW VGFVLLWAFS CFIFVTANII LSETKL
Length:496
Mass (Da):55,679
Last modified:October 31, 2006 - v2
Checksum:i4173D25DB4870426
GO
Isoform 2 (identifier: Q8NE00-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-314: AFAVMIVLAL...RLVFLDYVLI → DGPPGSVMGR...LPPHRSTRPT
     315-496: Missing.

Note: No experimental confirmation available.

Show »
Length:314
Mass (Da):34,796
Checksum:i405BCEC0DFFCAEE9
GO

Sequence cautioni

The sequence BAB84855.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581V → M.2 Publications
Corresponds to variant rs2016126 [ dbSNP | Ensembl ].
VAR_028831
Natural varianti439 – 4391A → T.
Corresponds to variant rs3803784 [ dbSNP | Ensembl ].
VAR_028832

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei244 – 31471AFAVM…DYVLI → DGPPGSVMGRAEEDASPAWP RSRCRCGGKLKLNSLYPTSA TCMAPDAPGAGQVKVGVNFL CLPPHRSTRPT in isoform 2. 1 PublicationVSP_021199Add
BLAST
Alternative sequencei315 – 496182Missing in isoform 2. 1 PublicationVSP_021200Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000262 mRNA. Translation: BAA91039.1.
AK074029 mRNA. Translation: BAB84855.1. Different initiation.
BC037278 mRNA. Translation: AAH37278.1.
AL137521 mRNA. Translation: CAB70787.1.
CCDSiCCDS32723.1. [Q8NE00-1]
PIRiT46367.
RefSeqiNP_060198.3. NM_017728.3. [Q8NE00-1]
XP_005257538.1. XM_005257481.1. [Q8NE00-2]
UniGeneiHs.370262.

Genome annotation databases

EnsembliENST00000335464; ENSP00000334849; ENSG00000109066. [Q8NE00-1]
ENST00000582330; ENSP00000461922; ENSG00000109066. [Q8NE00-1]
ENST00000582773; ENSP00000463205; ENSG00000109066. [Q8NE00-2]
GeneIDi54868.
KEGGihsa:54868.
UCSCiuc002jls.4. human. [Q8NE00-1]
uc010wrf.1. human. [Q8NE00-2]

Polymorphism databases

DMDMi117949798.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000262 mRNA. Translation: BAA91039.1.
AK074029 mRNA. Translation: BAB84855.1. Different initiation.
BC037278 mRNA. Translation: AAH37278.1.
AL137521 mRNA. Translation: CAB70787.1.
CCDSiCCDS32723.1. [Q8NE00-1]
PIRiT46367.
RefSeqiNP_060198.3. NM_017728.3. [Q8NE00-1]
XP_005257538.1. XM_005257481.1. [Q8NE00-2]
UniGeneiHs.370262.

3D structure databases

ProteinModelPortaliQ8NE00.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120217. 3 interactions.
IntActiQ8NE00. 1 interaction.
STRINGi9606.ENSP00000334849.

Protein family/group databases

TCDBi2.A.18.10.1. the amino acid/auxin permease (aaap) family.

PTM databases

PhosphoSiteiQ8NE00.

Polymorphism databases

DMDMi117949798.

Proteomic databases

MaxQBiQ8NE00.
PaxDbiQ8NE00.
PRIDEiQ8NE00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335464; ENSP00000334849; ENSG00000109066. [Q8NE00-1]
ENST00000582330; ENSP00000461922; ENSG00000109066. [Q8NE00-1]
ENST00000582773; ENSP00000463205; ENSG00000109066. [Q8NE00-2]
GeneIDi54868.
KEGGihsa:54868.
UCSCiuc002jls.4. human. [Q8NE00-1]
uc010wrf.1. human. [Q8NE00-2]

Organism-specific databases

CTDi54868.
GeneCardsiGC17P072772.
HGNCiHGNC:25984. TMEM104.
HPAiHPA044330.
neXtProtiNX_Q8NE00.
PharmGKBiPA142670753.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG242666.
GeneTreeiENSGT00390000001244.
HOGENOMiHOG000231060.
HOVERGENiHBG080085.
InParanoidiQ8NE00.
OMAiDSLMDMY.
PhylomeDBiQ8NE00.
TreeFamiTF314030.

Miscellaneous databases

ChiTaRSiTMEM104. human.
GenomeRNAii54868.
NextBioi57775.
PROiQ8NE00.

Gene expression databases

BgeeiQ8NE00.
CleanExiHS_TMEM104.
ExpressionAtlasiQ8NE00. baseline and differential.
GenevestigatoriQ8NE00.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-58.
    Tissue: Colon mucosa and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-58.
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 243-496 (ISOFORM 1).
    Tissue: Testis.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM104_HUMAN
AccessioniPrimary (citable) accession number: Q8NE00
Secondary accession number(s): Q8TEU1, Q9NT56, Q9NXH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: January 7, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.