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Q8NE00

- TM104_HUMAN

UniProt

Q8NE00 - TM104_HUMAN

Protein

Transmembrane protein 104

Gene

TMEM104

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Protein family/group databases

    TCDBi2.A.18.10.1. the amino acid/auxin permease (aaap) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 104
    Gene namesi
    Name:TMEM104
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:25984. TMEM104.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670753.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Transmembrane protein 104PRO_0000254178Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8NE00.
    PaxDbiQ8NE00.
    PRIDEiQ8NE00.

    PTM databases

    PhosphoSiteiQ8NE00.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NE00.
    BgeeiQ8NE00.
    CleanExiHS_TMEM104.
    GenevestigatoriQ8NE00.

    Organism-specific databases

    HPAiHPA044330.

    Interactioni

    Protein-protein interaction databases

    BioGridi120217. 2 interactions.
    IntActiQ8NE00. 1 interaction.
    STRINGi9606.ENSP00000334849.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NE00.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 365ExtracellularSequence Analysis
    Topological domaini58 – 14689CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini168 – 20437ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini226 – 2338CytoplasmicSequence Analysis
    Topological domaini255 – 27622ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini298 – 3069CytoplasmicSequence Analysis
    Topological domaini328 – 35427ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini376 – 39722CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini419 – 4213ExtracellularSequence Analysis
    Topological domaini443 – 47028CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini492 – 4965ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei37 – 5721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei307 – 32721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei355 – 37521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei398 – 41821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei422 – 44221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei471 – 49121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM104 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG242666.
    HOGENOMiHOG000231060.
    HOVERGENiHBG080085.
    InParanoidiQ8NE00.
    OMAiDSLMDMY.
    PhylomeDBiQ8NE00.
    TreeFamiTF314030.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NE00-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGEITETGE LYSSYVGLVY MFNLIVGTGA LTMPKAFATA GWLVSLVLLV    50
    FLGFMSFVTT TFVIEAMAAA NAQLHWKRME NLKEEEDDDS STASDSDVLI 100
    RDNYERAEKR PILSVQRRGS PNPFEITDRV EMGQMASMFF NKVGVNLFYF 150
    CIIVYLYGDL AIYAAAVPFS LMQVTCSATG NDSCGVEADT KYNDTDRCWG 200
    PLRRVDAYRI YLAIFTLLLG PFTFFDVQKT KYLQILTSLM RWIAFAVMIV 250
    LALIRIGHGQ GEGHPPLADF SGVRNLFGVC VYSFMCQHSL PSLITPVSSK 300
    RHLTRLVFLD YVLILAFYGL LSFTAIFCFR GDSLMDMYTL NFARCDVVGL 350
    AAVRFFLGLF PVFTISTNFP IIAVTLRNNW KTLFHREGGT YPWVVDRVVF 400
    PTITLVPPVL VAFCTHDLES LVGITGAYAG TGIQYVIPAF LVYHCRRDTQ 450
    LAFGCGVSNK HRSPFRHTFW VGFVLLWAFS CFIFVTANII LSETKL 496
    Length:496
    Mass (Da):55,679
    Last modified:October 31, 2006 - v2
    Checksum:i4173D25DB4870426
    GO
    Isoform 2 (identifier: Q8NE00-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         244-314: AFAVMIVLAL...RLVFLDYVLI → DGPPGSVMGR...LPPHRSTRPT
         315-496: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:314
    Mass (Da):34,796
    Checksum:i405BCEC0DFFCAEE9
    GO

    Sequence cautioni

    The sequence BAB84855.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti58 – 581V → M.2 Publications
    Corresponds to variant rs2016126 [ dbSNP | Ensembl ].
    VAR_028831
    Natural varianti439 – 4391A → T.
    Corresponds to variant rs3803784 [ dbSNP | Ensembl ].
    VAR_028832

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei244 – 31471AFAVM…DYVLI → DGPPGSVMGRAEEDASPAWP RSRCRCGGKLKLNSLYPTSA TCMAPDAPGAGQVKVGVNFL CLPPHRSTRPT in isoform 2. 1 PublicationVSP_021199Add
    BLAST
    Alternative sequencei315 – 496182Missing in isoform 2. 1 PublicationVSP_021200Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000262 mRNA. Translation: BAA91039.1.
    AK074029 mRNA. Translation: BAB84855.1. Different initiation.
    BC037278 mRNA. Translation: AAH37278.1.
    AL137521 mRNA. Translation: CAB70787.1.
    CCDSiCCDS32723.1. [Q8NE00-1]
    PIRiT46367.
    RefSeqiNP_060198.3. NM_017728.3. [Q8NE00-1]
    XP_005257538.1. XM_005257481.1. [Q8NE00-2]
    UniGeneiHs.370262.

    Genome annotation databases

    EnsembliENST00000335464; ENSP00000334849; ENSG00000109066. [Q8NE00-1]
    ENST00000582330; ENSP00000461922; ENSG00000109066. [Q8NE00-1]
    ENST00000582773; ENSP00000463205; ENSG00000109066. [Q8NE00-2]
    GeneIDi54868.
    KEGGihsa:54868.
    UCSCiuc002jls.4. human. [Q8NE00-1]
    uc010wrf.1. human. [Q8NE00-2]

    Polymorphism databases

    DMDMi117949798.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000262 mRNA. Translation: BAA91039.1 .
    AK074029 mRNA. Translation: BAB84855.1 . Different initiation.
    BC037278 mRNA. Translation: AAH37278.1 .
    AL137521 mRNA. Translation: CAB70787.1 .
    CCDSi CCDS32723.1. [Q8NE00-1 ]
    PIRi T46367.
    RefSeqi NP_060198.3. NM_017728.3. [Q8NE00-1 ]
    XP_005257538.1. XM_005257481.1. [Q8NE00-2 ]
    UniGenei Hs.370262.

    3D structure databases

    ProteinModelPortali Q8NE00.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120217. 2 interactions.
    IntActi Q8NE00. 1 interaction.
    STRINGi 9606.ENSP00000334849.

    Protein family/group databases

    TCDBi 2.A.18.10.1. the amino acid/auxin permease (aaap) family.

    PTM databases

    PhosphoSitei Q8NE00.

    Polymorphism databases

    DMDMi 117949798.

    Proteomic databases

    MaxQBi Q8NE00.
    PaxDbi Q8NE00.
    PRIDEi Q8NE00.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335464 ; ENSP00000334849 ; ENSG00000109066 . [Q8NE00-1 ]
    ENST00000582330 ; ENSP00000461922 ; ENSG00000109066 . [Q8NE00-1 ]
    ENST00000582773 ; ENSP00000463205 ; ENSG00000109066 . [Q8NE00-2 ]
    GeneIDi 54868.
    KEGGi hsa:54868.
    UCSCi uc002jls.4. human. [Q8NE00-1 ]
    uc010wrf.1. human. [Q8NE00-2 ]

    Organism-specific databases

    CTDi 54868.
    GeneCardsi GC17P072772.
    HGNCi HGNC:25984. TMEM104.
    HPAi HPA044330.
    neXtProti NX_Q8NE00.
    PharmGKBi PA142670753.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG242666.
    HOGENOMi HOG000231060.
    HOVERGENi HBG080085.
    InParanoidi Q8NE00.
    OMAi DSLMDMY.
    PhylomeDBi Q8NE00.
    TreeFami TF314030.

    Miscellaneous databases

    ChiTaRSi TMEM104. human.
    GenomeRNAii 54868.
    NextBioi 57775.
    PROi Q8NE00.

    Gene expression databases

    ArrayExpressi Q8NE00.
    Bgeei Q8NE00.
    CleanExi HS_TMEM104.
    Genevestigatori Q8NE00.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-58.
      Tissue: Colon mucosa and Spleen.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-58.
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 243-496 (ISOFORM 1).
      Tissue: Testis.
    4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTM104_HUMAN
    AccessioniPrimary (citable) accession number: Q8NE00
    Secondary accession number(s): Q8TEU1, Q9NT56, Q9NXH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3