Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NE00 (TM104_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 104
Gene names
Name:TMEM104
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length496 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TMEM104 family.

Sequence caution

The sequence BAB84855.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NE00-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NE00-2)

The sequence of this isoform differs from the canonical sequence as follows:
     244-314: AFAVMIVLAL...RLVFLDYVLI → DGPPGSVMGR...LPPHRSTRPT
     315-496: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 496496Transmembrane protein 104
PRO_0000254178

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121Helical; Potential
Topological domain32 – 365Extracellular Potential
Transmembrane37 – 5721Helical; Potential
Topological domain58 – 14689Cytoplasmic Potential
Transmembrane147 – 16721Helical; Potential
Topological domain168 – 20437Extracellular Potential
Transmembrane205 – 22521Helical; Potential
Topological domain226 – 2338Cytoplasmic Potential
Transmembrane234 – 25421Helical; Potential
Topological domain255 – 27622Extracellular Potential
Transmembrane277 – 29721Helical; Potential
Topological domain298 – 3069Cytoplasmic Potential
Transmembrane307 – 32721Helical; Potential
Topological domain328 – 35427Extracellular Potential
Transmembrane355 – 37521Helical; Potential
Topological domain376 – 39722Cytoplasmic Potential
Transmembrane398 – 41821Helical; Potential
Topological domain419 – 4213Extracellular Potential
Transmembrane422 – 44221Helical; Potential
Topological domain443 – 47028Cytoplasmic Potential
Transmembrane471 – 49121Helical; Potential
Topological domain492 – 4965Extracellular Potential

Amino acid modifications

Glycosylation1931N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence244 – 31471AFAVM…DYVLI → DGPPGSVMGRAEEDASPAWP RSRCRCGGKLKLNSLYPTSA TCMAPDAPGAGQVKVGVNFL CLPPHRSTRPT in isoform 2.
VSP_021199
Alternative sequence315 – 496182Missing in isoform 2.
VSP_021200
Natural variant581V → M. Ref.1 Ref.2
Corresponds to variant rs2016126 [ dbSNP | Ensembl ].
VAR_028831
Natural variant4391A → T.
Corresponds to variant rs3803784 [ dbSNP | Ensembl ].
VAR_028832

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 31, 2006. Version 2.
Checksum: 4173D25DB4870426

FASTA49655,679
        10         20         30         40         50         60 
MAGEITETGE LYSSYVGLVY MFNLIVGTGA LTMPKAFATA GWLVSLVLLV FLGFMSFVTT 

        70         80         90        100        110        120 
TFVIEAMAAA NAQLHWKRME NLKEEEDDDS STASDSDVLI RDNYERAEKR PILSVQRRGS 

       130        140        150        160        170        180 
PNPFEITDRV EMGQMASMFF NKVGVNLFYF CIIVYLYGDL AIYAAAVPFS LMQVTCSATG 

       190        200        210        220        230        240 
NDSCGVEADT KYNDTDRCWG PLRRVDAYRI YLAIFTLLLG PFTFFDVQKT KYLQILTSLM 

       250        260        270        280        290        300 
RWIAFAVMIV LALIRIGHGQ GEGHPPLADF SGVRNLFGVC VYSFMCQHSL PSLITPVSSK 

       310        320        330        340        350        360 
RHLTRLVFLD YVLILAFYGL LSFTAIFCFR GDSLMDMYTL NFARCDVVGL AAVRFFLGLF 

       370        380        390        400        410        420 
PVFTISTNFP IIAVTLRNNW KTLFHREGGT YPWVVDRVVF PTITLVPPVL VAFCTHDLES 

       430        440        450        460        470        480 
LVGITGAYAG TGIQYVIPAF LVYHCRRDTQ LAFGCGVSNK HRSPFRHTFW VGFVLLWAFS 

       490 
CFIFVTANII LSETKL 

« Hide

Isoform 2 [UniParc].

Checksum: 405BCEC0DFFCAEE9
Show »

FASTA31434,796

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-58.
Tissue: Colon mucosa and Spleen.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-58.
Tissue: Testis.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 243-496 (ISOFORM 1).
Tissue: Testis.
[4]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK000262 mRNA. Translation: BAA91039.1.
AK074029 mRNA. Translation: BAB84855.1. Different initiation.
BC037278 mRNA. Translation: AAH37278.1.
AL137521 mRNA. Translation: CAB70787.1.
CCDSCCDS32723.1. [Q8NE00-1]
PIRT46367.
RefSeqNP_060198.3. NM_017728.3. [Q8NE00-1]
XP_005257538.1. XM_005257481.1. [Q8NE00-2]
UniGeneHs.370262.

3D structure databases

ProteinModelPortalQ8NE00.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120217. 2 interactions.
IntActQ8NE00. 1 interaction.
STRING9606.ENSP00000334849.

Protein family/group databases

TCDB2.A.18.10.1. the amino acid/auxin permease (aaap) family.

PTM databases

PhosphoSiteQ8NE00.

Polymorphism databases

DMDM117949798.

Proteomic databases

MaxQBQ8NE00.
PaxDbQ8NE00.
PRIDEQ8NE00.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000335464; ENSP00000334849; ENSG00000109066. [Q8NE00-1]
ENST00000582330; ENSP00000461922; ENSG00000109066. [Q8NE00-1]
ENST00000582773; ENSP00000463205; ENSG00000109066. [Q8NE00-2]
GeneID54868.
KEGGhsa:54868.
UCSCuc002jls.4. human. [Q8NE00-1]
uc010wrf.1. human. [Q8NE00-2]

Organism-specific databases

CTD54868.
GeneCardsGC17P072772.
HGNCHGNC:25984. TMEM104.
HPAHPA044330.
neXtProtNX_Q8NE00.
PharmGKBPA142670753.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG242666.
HOGENOMHOG000231060.
HOVERGENHBG080085.
InParanoidQ8NE00.
OMADSLMDMY.
PhylomeDBQ8NE00.
TreeFamTF314030.

Gene expression databases

ArrayExpressQ8NE00.
BgeeQ8NE00.
CleanExHS_TMEM104.
GenevestigatorQ8NE00.

Family and domain databases

InterProIPR013057. AA_transpt_TM.
[Graphical view]
PfamPF01490. Aa_trans. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTMEM104. human.
GenomeRNAi54868.
NextBio57775.
PROQ8NE00.

Entry information

Entry nameTM104_HUMAN
AccessionPrimary (citable) accession number: Q8NE00
Secondary accession number(s): Q8TEU1, Q9NT56, Q9NXH1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM