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Protein

BEN domain-containing protein 2

Gene

BEND2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
BEN domain-containing protein 2
Gene namesi
Name:BEND2
Synonyms:CXorf20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000177324.13
HGNCiHGNC:28509 BEND2
neXtProtiNX_Q8NDZ0

Pathology & Biotechi

Organism-specific databases

DisGeNETi139105
OpenTargetsiENSG00000177324
PharmGKBiPA164716507

Polymorphism and mutation databases

BioMutaiBEND2
DMDMi71153248

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000797301 – 799BEN domain-containing protein 2Add BLAST799

Proteomic databases

PaxDbiQ8NDZ0
PeptideAtlasiQ8NDZ0
PRIDEiQ8NDZ0
ProteomicsDBi73095

PTM databases

iPTMnetiQ8NDZ0
PhosphoSitePlusiQ8NDZ0

Expressioni

Gene expression databases

BgeeiENSG00000177324
CleanExiHS_BEND2
GenevisibleiQ8NDZ0 HS

Organism-specific databases

HPAiHPA009420
HPA013142

Interactioni

Protein-protein interaction databases

BioGridi126543, 2 interactors
IntActiQ8NDZ0, 4 interactors
STRINGi9606.ENSP00000369372

Structurei

3D structure databases

ProteinModelPortaliQ8NDZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini483 – 582BEN 1PROSITE-ProRule annotationAdd BLAST100
Domaini667 – 765BEN 2PROSITE-ProRule annotationAdd BLAST99

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHY9 Eukaryota
ENOG4111SGS LUCA
GeneTreeiENSGT00510000049851
HOGENOMiHOG000095198
HOVERGENiHBG081386
InParanoidiQ8NDZ0
OMAiYGYLGDP
OrthoDBiEOG091G0N5E
PhylomeDBiQ8NDZ0
TreeFamiTF336206

Family and domain databases

InterProiView protein in InterPro
IPR018379 BEN_domain
PfamiView protein in Pfam
PF10523 BEN, 2 hits
SMARTiView protein in SMART
SM01025 BEN, 2 hits
PROSITEiView protein in PROSITE
PS51457 BEN, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NDZ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSERTQEQDF VIITVDDSDD NNDCSIEMVE VSETADNSTN DIADDSTYVT
60 70 80 90 100
ADNPTDDTAT QPNFPGGNDG HHRPLQMSYG SGSVTQAGVQ WHDHSSLQPQ
110 120 130 140 150
PLGLKQFFHL SLPSSWDDRR TPPCPVAHGD QIVSQINHPV HLRRYSYNSE
160 170 180 190 200
EVDFPKRGRF YTPEVQSSIS PPAERQETHA WASPAVTSLE SAACHELQEA
210 220 230 240 250
DLSESLSYPR IVSSSSLQQY VAQGGSFPCF GMPWNFISGG AESTNAVISF
260 270 280 290 300
ANATTAVPMA VLSRRESSLA NNPGVVNYSA LPENENVGPG RALSSFCFHP
310 320 330 340 350
NLEMPERPAN SSKNSTETAN YPTLMGNYNG QNTASLSVFI PPYFAEKIIL
360 370 380 390 400
TEMPGTTETN VENNSQTVYY PALSGNTSAP YPASSYLPIT SNFESGPQMS
410 420 430 440 450
YGTMSYSTEM KNNCDQDDAS ASACLTPDFA LLPLNILVKV DTNTENSVNT
460 470 480 490 500
MNRSTLLDSD SGQDSSSSSV CIPPKYGYLG DPKRNVRVLK IHLLAVQNMA
510 520 530 540 550
KPKQAACYLV RILFSKEILI SSSVDIHLKD SQSLDPNKMA ALREYLATTF
560 570 580 590 600
PTCDLHEHGK DWQDCISGIN SMIYCLCSEG KSTPKTVRKN KKRTNRVASA
610 620 630 640 650
SADRNDQRGR DGGEGCSWMF QPMNNSKMRE KRNLQPNSNA IPEGMREPST
660 670 680 690 700
DNPEEPGEAW SYFGRPWRNI RMPCSVLTLA KTKSCASLSA RYLIQKLFTK
710 720 730 740 750
DVLVQSNVYG NLKHGLCALD PNKISALREF LQENYPICDL SENGRDWKSC
760 770 780 790
VTSINSGIRS LRHDVRRAEA RSQSLPAVTP PELEQESKPG DPDATDPST
Length:799
Mass (Da):87,919
Last modified:July 19, 2005 - v2
Checksum:iFB6FE275C51F5A7B
GO
Isoform 2 (identifier: Q8NDZ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     303-393: Missing.
     729-799: EFLQENYPIC...GDPDATDPST → GLLHIEYV

Note: No experimental confirmation available.
Show »
Length:645
Mass (Da):71,075
Checksum:iF0F06BC1CDCFCEDF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti439K → E in AAH96745 (PubMed:15489334).Curated1
Sequence conflicti630E → V in AAH37301 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022885154F → L. Corresponds to variant dbSNP:rs17274127Ensembl.1
Natural variantiVAR_050935188S → F. Corresponds to variant dbSNP:rs12859329Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044653303 – 393Missing in isoform 2. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_044654729 – 799EFLQE…TDPST → GLLHIEYV in isoform 2. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096763 Genomic DNA No translation available.
BC037301 mRNA Translation: AAH37301.1
BC096745 mRNA Translation: AAH96745.1
CCDSiCCDS14184.1 [Q8NDZ0-1]
CCDS55375.1 [Q8NDZ0-2]
RefSeqiNP_001171696.1, NM_001184767.1 [Q8NDZ0-2]
NP_699177.2, NM_153346.4 [Q8NDZ0-1]
UniGeneiHs.403802

Genome annotation databases

EnsembliENST00000380030; ENSP00000369369; ENSG00000177324 [Q8NDZ0-2]
ENST00000380033; ENSP00000369372; ENSG00000177324 [Q8NDZ0-1]
GeneIDi139105
KEGGihsa:139105
UCSCiuc004cyj.5 human [Q8NDZ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBEND2_HUMAN
AccessioniPrimary (citable) accession number: Q8NDZ0
Secondary accession number(s): E9PFY2, Q4V9S2, Q5JXE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: June 20, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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