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Protein

Myelodysplastic syndrome 2 translocation-associated protein

Gene

MDS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Myelodysplastic syndrome 2 translocation-associated protein
Gene namesi
Name:MDS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29633. MDS2.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving MDS2 is a cause of myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with ETV6.

Keywords - Diseasei

Proto-oncogene

Polymorphism and mutation databases

DMDMi74751237.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Myelodysplastic syndrome 2 translocation-associated proteinPRO_0000252477Add
BLAST

Proteomic databases

EPDiQ8NDY4.
PaxDbiQ8NDY4.
PRIDEiQ8NDY4.

Expressioni

Tissue specificityi

Highly expressed in peripheral blood leukocytes, spleen, thymus, kidney, pancreas and lung.1 Publication

Gene expression databases

BgeeiENSG00000197880.
CleanExiHS_MDS2.
ExpressionAtlasiQ8NDY4. baseline and differential.
GenevisibleiQ8NDY4. HS.

Organism-specific databases

HPAiHPA052999.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363683.

Structurei

3D structure databases

ProteinModelPortaliQ8NDY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410KF2D. Eukaryota.
ENOG4110NT4. LUCA.
GeneTreeiENSGT00390000000704.
HOGENOMiHOG000113512.
InParanoidiQ8NDY4.
OMAiPPCEDPA.
OrthoDBiEOG091G0RU5.
PhylomeDBiQ8NDY4.

Sequencei

Sequence statusi: Complete.

Q8NDY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQAADFIER TETAGELSRG LIGVLSSQIS WCLLNVNLSK LPTRLQRLSC
60 70 80 90 100
SVLNSSPAMR GGARGRPQLT LERPLRPGCR LHSCSEAEKG GFVRRKEIIL
110 120 130 140
FPPCEDPARG WLSANPGREP SPGICWHLNL GLPSLHNCEE
Length:140
Mass (Da):15,384
Last modified:October 1, 2002 - v1
Checksum:i839BC22233659334
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310434 mRNA. Translation: CAD27416.1.
AL451000 Genomic DNA. Translation: CAH71470.1.
UniGeneiHs.523369.

Genome annotation databases

EnsembliENST00000374555; ENSP00000363683; ENSG00000197880.
UCSCiuc057dgf.1. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310434 mRNA. Translation: CAD27416.1.
AL451000 Genomic DNA. Translation: CAH71470.1.
UniGeneiHs.523369.

3D structure databases

ProteinModelPortaliQ8NDY4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000363683.

Polymorphism and mutation databases

DMDMi74751237.

Proteomic databases

EPDiQ8NDY4.
PaxDbiQ8NDY4.
PRIDEiQ8NDY4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374555; ENSP00000363683; ENSG00000197880.
UCSCiuc057dgf.1. human.

Organism-specific databases

GeneCardsiMDS2.
H-InvDBHIX0028629.
HGNCiHGNC:29633. MDS2.
HPAiHPA052999.
MIMi607305. gene.
neXtProtiNX_Q8NDY4.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KF2D. Eukaryota.
ENOG4110NT4. LUCA.
GeneTreeiENSGT00390000000704.
HOGENOMiHOG000113512.
InParanoidiQ8NDY4.
OMAiPPCEDPA.
OrthoDBiEOG091G0RU5.
PhylomeDBiQ8NDY4.

Miscellaneous databases

ChiTaRSiMDS2. human.
PROiQ8NDY4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197880.
CleanExiHS_MDS2.
ExpressionAtlasiQ8NDY4. baseline and differential.
GenevisibleiQ8NDY4. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiMDS2_HUMAN
AccessioniPrimary (citable) accession number: Q8NDY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.