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Q8NDY3 (ARHL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
[Protein ADP-ribosylarginine] hydrolase-like protein 1

EC=3.2.-.-
Alternative name(s):
ADP-ribosylhydrolase 2
Gene names
Name:ADPRHL1
Synonyms:ARH2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ADP-ribosylglycohydrolase family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein de-ADP-ribosylation

Inferred from electronic annotation. Source: InterPro

   Molecular_functionADP-ribosylarginine hydrolase activity

Inferred from electronic annotation. Source: InterPro

magnesium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NDY3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NDY3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354[Protein ADP-ribosylarginine] hydrolase-like protein 1
PRO_0000277606

Natural variations

Alternative sequence1 – 8282Missing in isoform 2.
VSP_023036
Natural variant71A → V.
Corresponds to variant rs9577273 [ dbSNP | Ensembl ].
VAR_048890

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: B880003EB955EB78

FASTA35440,105
        10         20         30         40         50         60 
MEKFKAAMLL GSVGDALGYR NVCKENSTVG MKIQEELQRS GGLDHLVLSP GEWPVSDNTI 

        70         80         90        100        110        120 
MHIATAEALT TDYWCLDDLY REMVRCYVEI VEKLPERRPD PATIEGCAQL KPNNYLLAWH 

       130        140        150        160        170        180 
TPFNEKGSGF GAATKAMCIG LRYWKPERLE TLIEVSVECG RMTHNHPTGF LGSLCTALFV 

       190        200        210        220        230        240 
SFAAQGKPLV QWGRDMLRAV PLAEEYCRKT IRHTAEYQEH WFYFEAKWQF YLEERKISKD 

       250        260        270        280        290        300 
SENKAIFPDN YDAEEREKTY RKWSSEGRGG RRGHDAPMIA YDALLAAGNS WTELCHRAMF 

       310        320        330        340        350 
HGGESAATGT IAGCLFGLLY GLDLVPKGLY QDLEDKEKLE DLGAALYRLS TEEK 

« Hide

Isoform 2 [UniParc].

Checksum: 9B18823AD729957E
Show »

FASTA27230,988

References

« Hide 'large scale' references
[1]"The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse."
Glowacki G., Braren R., Firner K., Nissen M., Kuehl M., Reche P., Bazan J.F., Cetkovic-Cvrlje M., Leiter E., Haag F., Koch-Nolte F.
Protein Sci. 11:1657-1670(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ313429 mRNA. Translation: CAC86114.1.
AL160251 Genomic DNA. Translation: CAI39433.1.
AL160251 Genomic DNA. Translation: CAI39434.1.
AL160251 Genomic DNA. Translation: CAI39435.1.
BC009755 mRNA. Translation: AAH09755.1.
CCDSCCDS9535.1. [Q8NDY3-1]
CCDS9536.1. [Q8NDY3-2]
RefSeqNP_612439.2. NM_138430.4. [Q8NDY3-1]
NP_954631.1. NM_199162.2. [Q8NDY3-2]
UniGeneHs.98669.

3D structure databases

ProteinModelPortalQ8NDY3.
SMRQ8NDY3. Positions 1-353.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000364567.

PTM databases

PhosphoSiteQ8NDY3.

Proteomic databases

PaxDbQ8NDY3.
PRIDEQ8NDY3.

Protocols and materials databases

DNASU113622.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000356501; ENSP00000348894; ENSG00000153531. [Q8NDY3-2]
ENST00000375418; ENSP00000364567; ENSG00000153531. [Q8NDY3-1]
GeneID113622.
KEGGhsa:113622.
UCSCuc001vtp.1. human. [Q8NDY3-1]

Organism-specific databases

CTD113622.
GeneCardsGC13M114076.
HGNCHGNC:21303. ADPRHL1.
MIM610620. gene.
neXtProtNX_Q8NDY3.
PharmGKBPA134870688.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47036.
HOGENOMHOG000007974.
HOVERGENHBG050462.
InParanoidQ8NDY3.
OMAVGMRYWQ.
OrthoDBEOG7SFHWT.
PhylomeDBQ8NDY3.
TreeFamTF329417.

Gene expression databases

BgeeQ8NDY3.
CleanExHS_ADPRHL1.
GenevestigatorQ8NDY3.

Family and domain databases

InterProIPR012108. ADP-ribosylarg_hydro.
IPR005502. Ribosyl_crysJ1.
[Graphical view]
PfamPF03747. ADP_ribosyl_GH. 1 hit.
[Graphical view]
PIRSFPIRSF016939. ADP_ribslarg_hdr. 1 hit.
SUPFAMSSF101478. SSF101478. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi113622.
NextBio78878.
PROQ8NDY3.
SOURCESearch...

Entry information

Entry nameARHL1_HUMAN
AccessionPrimary (citable) accession number: Q8NDY3
Secondary accession number(s): Q5JUG2, Q96GD1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM