Q8NDY3 (ARHL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
[Protein ADP-ribosylarginine] hydrolase-like protein 1

Alternative name(s):
ADP-ribosylhydrolase 2

Gene names

Name:	ADPRHL1
Synonyms:	ARH2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ADP-ribosylglycohydrolase family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein de-ADP-ribosylation Inferred from electronic annotation. Source: InterPro
Molecular function	ADP-ribosylarginine hydrolase activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NDY3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NDY3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	[Protein ADP-ribosylarginine] hydrolase-like protein 1		PRO_0000277606
Natural variations
	Alternative sequence	1 – 82	82	Missing in isoform 2.		VSP_023036
	Natural variant	7	1	A → V. Corresponds to variant rs9577273 [ dbSNP | Ensembl ].		VAR_048890

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: B880003EB955EB78	FASTA	354	40,105
	10 20 30 40 50 60 MEKFKAAMLL GSVGDALGYR NVCKENSTVG MKIQEELQRS GGLDHLVLSP GEWPVSDNTI 70 80 90 100 110 120 MHIATAEALT TDYWCLDDLY REMVRCYVEI VEKLPERRPD PATIEGCAQL KPNNYLLAWH 130 140 150 160 170 180 TPFNEKGSGF GAATKAMCIG LRYWKPERLE TLIEVSVECG RMTHNHPTGF LGSLCTALFV 190 200 210 220 230 240 SFAAQGKPLV QWGRDMLRAV PLAEEYCRKT IRHTAEYQEH WFYFEAKWQF YLEERKISKD 250 260 270 280 290 300 SENKAIFPDN YDAEEREKTY RKWSSEGRGG RRGHDAPMIA YDALLAAGNS WTELCHRAMF 310 320 330 340 350 HGGESAATGT IAGCLFGLLY GLDLVPKGLY QDLEDKEKLE DLGAALYRLS TEEK
	Isoform 2 [UniParc]. Checksum: 9B18823AD729957E	FASTA	272	30,988
	10 20 30 40 50 60 MVRCYVEIVE KLPERRPDPA TIEGCAQLKP NNYLLAWHTP FNEKGSGFGA ATKAMCIGLR 70 80 90 100 110 120 YWKPERLETL IEVSVECGRM THNHPTGFLG SLCTALFVSF AAQGKPLVQW GRDMLRAVPL 130 140 150 160 170 180 AEEYCRKTIR HTAEYQEHWF YFEAKWQFYL EERKISKDSE NKAIFPDNYD AEEREKTYRK 190 200 210 220 230 240 WSSEGRGGRR GHDAPMIAYD ALLAAGNSWT ELCHRAMFHG GESAATGTIA GCLFGLLYGL 250 260 270 DLVPKGLYQD LEDKEKLEDL GAALYRLSTE EK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse." Glowacki G., Braren R., Firner K., Nissen M., Kuehl M., Reche P., Bazan J.F., Cetkovic-Cvrlje M., Leiter E., Haag F., Koch-Nolte F. Protein Sci. 11:1657-1670(2002) [PubMed: 12070318] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Ovary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ313429 mRNA. Translation: CAC86114.1. AL160251 Genomic DNA. Translation: CAI39433.1. AL160251 Genomic DNA. Translation: CAI39434.1. AL160251 Genomic DNA. Translation: CAI39435.1. BC009755 mRNA. Translation: AAH09755.1.
IPI	IPI00168620. IPI00396530.
RefSeq	NP_612439.2. NM_138430.3. NP_954631.1. NM_199162.1.
UniGene	Hs.98669.
3D structure databases
ProteinModelPortal	Q8NDY3.
SMR	Q8NDY3. Positions 1-354.
ModBase	Search...
PTM databases
PhosphoSite	Q8NDY3.
Polymorphism databases
DMDM	74751236.
Proteomic databases
PRIDE	Q8NDY3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000375418; ENSP00000364567; ENSG00000153531.
GeneID	113622.
KEGG	hsa:113622.
UCSC	uc001vtp.1. human. uc001vtq.1. human.
Organism-specific databases
CTD	113622.
GeneCards	GC13M114076.
H-InvDB	HIX0201996.
HGNC	HGNC:21303. ADPRHL1.
MIM	610620. gene.
neXtProt	NX_Q8NDY3.
PharmGKB	PA134870688.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12166.
GeneTree	ENSGT00530000063627.
HOGENOM	HBG715225.
HOVERGEN	HBG050462.
InParanoid	Q8NDY3.
OMA	KAMCVGM.
PhylomeDB	Q8NDY3.
Gene expression databases
ArrayExpress	Q8NDY3.
Bgee	Q8NDY3.
CleanEx	HS_ADPRHL1.
Genevestigator	Q8NDY3.
Family and domain databases
InterPro	IPR012108. ADP-ribosylarg_hydro. IPR005502. Ribosyl_crysJ1. [Graphical view]
Pfam	PF03747. ADP_ribosyl_GH. 1 hit. [Graphical view]
PIRSF	PIRSF016939. ADP_ribslarg_hdr. 1 hit.
SUPFAM	SSF101478. Ribosyl_crysJ1. 1 hit.
ProtoNet	Search...
Other
NextBio	78878.
SOURCE	Search...

Entry information

Entry name

ARHL1_HUMAN

Accession

Primary (citable) accession number: Q8NDY3
Secondary accession number(s): Q5JUG2, Q96GD1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.