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Q8NDY3

- ARHL1_HUMAN

UniProt

Q8NDY3 - ARHL1_HUMAN

Protein

[Protein ADP-ribosylarginine] hydrolase-like protein 1

Gene

ADPRHL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ADP-ribosylarginine hydrolase activity Source: InterPro
    2. magnesium ion binding Source: InterPro

    GO - Biological processi

    1. protein de-ADP-ribosylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    [Protein ADP-ribosylarginine] hydrolase-like protein 1 (EC:3.2.-.-)
    Alternative name(s):
    ADP-ribosylhydrolase 2
    Gene namesi
    Name:ADPRHL1
    Synonyms:ARH2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:21303. ADPRHL1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134870688.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354[Protein ADP-ribosylarginine] hydrolase-like protein 1PRO_0000277606Add
    BLAST

    Proteomic databases

    PaxDbiQ8NDY3.
    PRIDEiQ8NDY3.

    PTM databases

    PhosphoSiteiQ8NDY3.

    Expressioni

    Gene expression databases

    BgeeiQ8NDY3.
    CleanExiHS_ADPRHL1.
    GenevestigatoriQ8NDY3.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000364567.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NDY3.
    SMRiQ8NDY3. Positions 1-353.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ADP-ribosylglycohydrolase family.Curated

    Phylogenomic databases

    eggNOGiNOG47036.
    HOGENOMiHOG000007974.
    HOVERGENiHBG050462.
    InParanoidiQ8NDY3.
    OMAiVGMRYWQ.
    OrthoDBiEOG7SFHWT.
    PhylomeDBiQ8NDY3.
    TreeFamiTF329417.

    Family and domain databases

    InterProiIPR012108. ADP-ribosylarg_hydro.
    IPR005502. Ribosyl_crysJ1.
    [Graphical view]
    PfamiPF03747. ADP_ribosyl_GH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016939. ADP_ribslarg_hdr. 1 hit.
    SUPFAMiSSF101478. SSF101478. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NDY3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEKFKAAMLL GSVGDALGYR NVCKENSTVG MKIQEELQRS GGLDHLVLSP    50
    GEWPVSDNTI MHIATAEALT TDYWCLDDLY REMVRCYVEI VEKLPERRPD 100
    PATIEGCAQL KPNNYLLAWH TPFNEKGSGF GAATKAMCIG LRYWKPERLE 150
    TLIEVSVECG RMTHNHPTGF LGSLCTALFV SFAAQGKPLV QWGRDMLRAV 200
    PLAEEYCRKT IRHTAEYQEH WFYFEAKWQF YLEERKISKD SENKAIFPDN 250
    YDAEEREKTY RKWSSEGRGG RRGHDAPMIA YDALLAAGNS WTELCHRAMF 300
    HGGESAATGT IAGCLFGLLY GLDLVPKGLY QDLEDKEKLE DLGAALYRLS 350
    TEEK 354
    Length:354
    Mass (Da):40,105
    Last modified:October 1, 2002 - v1
    Checksum:iB880003EB955EB78
    GO
    Isoform 2 (identifier: Q8NDY3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-82: Missing.

    Show »
    Length:272
    Mass (Da):30,988
    Checksum:i9B18823AD729957E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71A → V.
    Corresponds to variant rs9577273 [ dbSNP | Ensembl ].
    VAR_048890

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8282Missing in isoform 2. 1 PublicationVSP_023036Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ313429 mRNA. Translation: CAC86114.1.
    AL160251 Genomic DNA. Translation: CAI39433.1.
    AL160251 Genomic DNA. Translation: CAI39434.1.
    AL160251 Genomic DNA. Translation: CAI39435.1.
    BC009755 mRNA. Translation: AAH09755.1.
    CCDSiCCDS9535.1. [Q8NDY3-1]
    CCDS9536.1. [Q8NDY3-2]
    RefSeqiNP_612439.2. NM_138430.4. [Q8NDY3-1]
    NP_954631.1. NM_199162.2. [Q8NDY3-2]
    UniGeneiHs.98669.

    Genome annotation databases

    EnsembliENST00000356501; ENSP00000348894; ENSG00000153531. [Q8NDY3-2]
    ENST00000375418; ENSP00000364567; ENSG00000153531. [Q8NDY3-1]
    GeneIDi113622.
    KEGGihsa:113622.
    UCSCiuc001vtp.1. human. [Q8NDY3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ313429 mRNA. Translation: CAC86114.1 .
    AL160251 Genomic DNA. Translation: CAI39433.1 .
    AL160251 Genomic DNA. Translation: CAI39434.1 .
    AL160251 Genomic DNA. Translation: CAI39435.1 .
    BC009755 mRNA. Translation: AAH09755.1 .
    CCDSi CCDS9535.1. [Q8NDY3-1 ]
    CCDS9536.1. [Q8NDY3-2 ]
    RefSeqi NP_612439.2. NM_138430.4. [Q8NDY3-1 ]
    NP_954631.1. NM_199162.2. [Q8NDY3-2 ]
    UniGenei Hs.98669.

    3D structure databases

    ProteinModelPortali Q8NDY3.
    SMRi Q8NDY3. Positions 1-353.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000364567.

    PTM databases

    PhosphoSitei Q8NDY3.

    Proteomic databases

    PaxDbi Q8NDY3.
    PRIDEi Q8NDY3.

    Protocols and materials databases

    DNASUi 113622.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356501 ; ENSP00000348894 ; ENSG00000153531 . [Q8NDY3-2 ]
    ENST00000375418 ; ENSP00000364567 ; ENSG00000153531 . [Q8NDY3-1 ]
    GeneIDi 113622.
    KEGGi hsa:113622.
    UCSCi uc001vtp.1. human. [Q8NDY3-1 ]

    Organism-specific databases

    CTDi 113622.
    GeneCardsi GC13M114076.
    HGNCi HGNC:21303. ADPRHL1.
    MIMi 610620. gene.
    neXtProti NX_Q8NDY3.
    PharmGKBi PA134870688.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47036.
    HOGENOMi HOG000007974.
    HOVERGENi HBG050462.
    InParanoidi Q8NDY3.
    OMAi VGMRYWQ.
    OrthoDBi EOG7SFHWT.
    PhylomeDBi Q8NDY3.
    TreeFami TF329417.

    Miscellaneous databases

    GenomeRNAii 113622.
    NextBioi 78878.
    PROi Q8NDY3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8NDY3.
    CleanExi HS_ADPRHL1.
    Genevestigatori Q8NDY3.

    Family and domain databases

    InterProi IPR012108. ADP-ribosylarg_hydro.
    IPR005502. Ribosyl_crysJ1.
    [Graphical view ]
    Pfami PF03747. ADP_ribosyl_GH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016939. ADP_ribslarg_hdr. 1 hit.
    SUPFAMi SSF101478. SSF101478. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse."
      Glowacki G., Braren R., Firner K., Nissen M., Kuehl M., Reche P., Bazan J.F., Cetkovic-Cvrlje M., Leiter E., Haag F., Koch-Nolte F.
      Protein Sci. 11:1657-1670(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Ovary.

    Entry informationi

    Entry nameiARHL1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NDY3
    Secondary accession number(s): Q5JUG2, Q96GD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3