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Protein

[Protein ADP-ribosylarginine] hydrolase-like protein 1

Gene

ADPRHL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
[Protein ADP-ribosylarginine] hydrolase-like protein 1 (EC:3.2.-.-)
Alternative name(s):
ADP-ribosylhydrolase 2
Gene namesi
Name:ADPRHL1
Synonyms:ARH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:21303. ADPRHL1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134870688.

Polymorphism and mutation databases

BioMutaiADPRHL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354[Protein ADP-ribosylarginine] hydrolase-like protein 1PRO_0000277606Add
BLAST

Proteomic databases

PaxDbiQ8NDY3.
PRIDEiQ8NDY3.

PTM databases

PhosphoSiteiQ8NDY3.

Expressioni

Gene expression databases

BgeeiQ8NDY3.
CleanExiHS_ADPRHL1.
ExpressionAtlasiQ8NDY3. baseline and differential.
GenevisibleiQ8NDY3. HS.

Organism-specific databases

HPAiHPA043951.
HPA066478.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000364567.

Structurei

3D structure databases

ProteinModelPortaliQ8NDY3.
SMRiQ8NDY3. Positions 1-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP-ribosylglycohydrolase family.Curated

Phylogenomic databases

eggNOGiNOG47036.
GeneTreeiENSGT00530000063627.
HOGENOMiHOG000007974.
HOVERGENiHBG050462.
InParanoidiQ8NDY3.
OMAiVGMRYWQ.
OrthoDBiEOG7SFHWT.
PhylomeDBiQ8NDY3.
TreeFamiTF329417.

Family and domain databases

InterProiIPR012108. ADP-ribosylarg_hydro.
IPR005502. Ribosyl_crysJ1.
[Graphical view]
PfamiPF03747. ADP_ribosyl_GH. 1 hit.
[Graphical view]
PIRSFiPIRSF016939. ADP_ribslarg_hdr. 1 hit.
SUPFAMiSSF101478. SSF101478. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NDY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKFKAAMLL GSVGDALGYR NVCKENSTVG MKIQEELQRS GGLDHLVLSP
60 70 80 90 100
GEWPVSDNTI MHIATAEALT TDYWCLDDLY REMVRCYVEI VEKLPERRPD
110 120 130 140 150
PATIEGCAQL KPNNYLLAWH TPFNEKGSGF GAATKAMCIG LRYWKPERLE
160 170 180 190 200
TLIEVSVECG RMTHNHPTGF LGSLCTALFV SFAAQGKPLV QWGRDMLRAV
210 220 230 240 250
PLAEEYCRKT IRHTAEYQEH WFYFEAKWQF YLEERKISKD SENKAIFPDN
260 270 280 290 300
YDAEEREKTY RKWSSEGRGG RRGHDAPMIA YDALLAAGNS WTELCHRAMF
310 320 330 340 350
HGGESAATGT IAGCLFGLLY GLDLVPKGLY QDLEDKEKLE DLGAALYRLS

TEEK
Length:354
Mass (Da):40,105
Last modified:October 1, 2002 - v1
Checksum:iB880003EB955EB78
GO
Isoform 2 (identifier: Q8NDY3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:272
Mass (Da):30,988
Checksum:i9B18823AD729957E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71A → V.
Corresponds to variant rs9577273 [ dbSNP | Ensembl ].
VAR_048890

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8282Missing in isoform 2. 1 PublicationVSP_023036Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313429 mRNA. Translation: CAC86114.1.
AL160251 Genomic DNA. Translation: CAI39433.1.
AL160251 Genomic DNA. Translation: CAI39434.1.
AL160251 Genomic DNA. Translation: CAI39435.1.
BC009755 mRNA. Translation: AAH09755.1.
CCDSiCCDS9535.1. [Q8NDY3-1]
CCDS9536.1. [Q8NDY3-2]
RefSeqiNP_612439.2. NM_138430.4. [Q8NDY3-1]
NP_954631.1. NM_199162.2. [Q8NDY3-2]
UniGeneiHs.98669.

Genome annotation databases

EnsembliENST00000356501; ENSP00000348894; ENSG00000153531. [Q8NDY3-2]
ENST00000375418; ENSP00000364567; ENSG00000153531.
GeneIDi113622.
KEGGihsa:113622.
UCSCiuc001vtp.1. human. [Q8NDY3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313429 mRNA. Translation: CAC86114.1.
AL160251 Genomic DNA. Translation: CAI39433.1.
AL160251 Genomic DNA. Translation: CAI39434.1.
AL160251 Genomic DNA. Translation: CAI39435.1.
BC009755 mRNA. Translation: AAH09755.1.
CCDSiCCDS9535.1. [Q8NDY3-1]
CCDS9536.1. [Q8NDY3-2]
RefSeqiNP_612439.2. NM_138430.4. [Q8NDY3-1]
NP_954631.1. NM_199162.2. [Q8NDY3-2]
UniGeneiHs.98669.

3D structure databases

ProteinModelPortaliQ8NDY3.
SMRiQ8NDY3. Positions 1-353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000364567.

PTM databases

PhosphoSiteiQ8NDY3.

Polymorphism and mutation databases

BioMutaiADPRHL1.

Proteomic databases

PaxDbiQ8NDY3.
PRIDEiQ8NDY3.

Protocols and materials databases

DNASUi113622.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356501; ENSP00000348894; ENSG00000153531. [Q8NDY3-2]
ENST00000375418; ENSP00000364567; ENSG00000153531.
GeneIDi113622.
KEGGihsa:113622.
UCSCiuc001vtp.1. human. [Q8NDY3-1]

Organism-specific databases

CTDi113622.
GeneCardsiGC13M114076.
HGNCiHGNC:21303. ADPRHL1.
HPAiHPA043951.
HPA066478.
MIMi610620. gene.
neXtProtiNX_Q8NDY3.
PharmGKBiPA134870688.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47036.
GeneTreeiENSGT00530000063627.
HOGENOMiHOG000007974.
HOVERGENiHBG050462.
InParanoidiQ8NDY3.
OMAiVGMRYWQ.
OrthoDBiEOG7SFHWT.
PhylomeDBiQ8NDY3.
TreeFamiTF329417.

Miscellaneous databases

GenomeRNAii113622.
NextBioi78878.
PROiQ8NDY3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NDY3.
CleanExiHS_ADPRHL1.
ExpressionAtlasiQ8NDY3. baseline and differential.
GenevisibleiQ8NDY3. HS.

Family and domain databases

InterProiIPR012108. ADP-ribosylarg_hydro.
IPR005502. Ribosyl_crysJ1.
[Graphical view]
PfamiPF03747. ADP_ribosyl_GH. 1 hit.
[Graphical view]
PIRSFiPIRSF016939. ADP_ribslarg_hdr. 1 hit.
SUPFAMiSSF101478. SSF101478. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse."
    Glowacki G., Braren R., Firner K., Nissen M., Kuehl M., Reche P., Bazan J.F., Cetkovic-Cvrlje M., Leiter E., Haag F., Koch-Nolte F.
    Protein Sci. 11:1657-1670(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Ovary.

Entry informationi

Entry nameiARHL1_HUMAN
AccessioniPrimary (citable) accession number: Q8NDY3
Secondary accession number(s): Q5JUG2, Q96GD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.