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Protein

Lymphocyte antigen 6 complex locus protein G5b

Gene

LY6G5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124649-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 6 complex locus protein G5b
Gene namesi
Name:LY6G5B
Synonyms:C6orf19, G5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13931. LY6G5B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi58496.
OpenTargetsiENSG00000240053.
ENSG00000240433.
ENSG00000241132.
ENSG00000241713.
ENSG00000244672.
PharmGKBiPA37826.

Polymorphism and mutation databases

BioMutaiLY6G5B.
DMDMi74751234.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000031860219 – 201Lymphocyte antigen 6 complex locus protein G5bAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 55By similarity
Disulfide bondi31 ↔ 40By similarity
Disulfide bondi47 ↔ 73By similarity
Disulfide bondi81 ↔ 98By similarity
Disulfide bondi99 ↔ 104By similarity
Glycosylationi141N-linked (GlcNAc...)Sequence analysis1
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NDX9.
PeptideAtlasiQ8NDX9.
PRIDEiQ8NDX9.

PTM databases

iPTMnetiQ8NDX9.
PhosphoSitePlusiQ8NDX9.

Expressioni

Gene expression databases

BgeeiENSG00000239285.
CleanExiHS_LY6G5B.
ExpressionAtlasiQ8NDX9. baseline and differential.
GenevisibleiQ8NDX9. HS.

Organism-specific databases

HPAiHPA048307.

Interactioni

Subunit structurei

Forms oligomer.1 Publication

Protein-protein interaction databases

BioGridi121826. 6 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8NDX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 118UPAR/Ly6Add BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi50 – 53Poly-Ser4

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II7T. Eukaryota.
ENOG41113GV. LUCA.
GeneTreeiENSGT00520000060793.
HOVERGENiHBG108361.
InParanoidiQ8NDX9.
KOiK20005.
OrthoDBiEOG091G0L9V.
PhylomeDBiQ8NDX9.
TreeFamiTF338717.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NDX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVHMLVGVL VMVGFTVGKV PVPDIRTCHF CLVEDPSVGC ISGSEKCTIS
60 70 80 90 100
SSSLCMVITI YYDVKVRFIV RGCGQYISYR CQEKRNTYFA EYWYQAQCCQ
110 120 130 140 150
YDYCNSWSSP QLQSSLPEPH DRPLALPLSD SQIQWFYQAL NLSLPLPNFH
160 170 180 190 200
AGTEPDGLDP MVTLSLNLGL SFAELRRMYL FLNSSGLLVL PQAGLLTPHP

S
Length:201
Mass (Da):22,572
Last modified:October 1, 2002 - v1
Checksum:iE2CDFCDD5E166056
GO
Isoform 2 (identifier: Q8NDX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.

Show »
Length:146
Mass (Da):16,792
Checksum:i5C12D119A0016C22
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038842102D → N.Corresponds to variant rs805267dbSNPEnsembl.1
Natural variantiVAR_038843131S → Y.Corresponds to variant rs11758242dbSNPEnsembl.1
Natural variantiVAR_038844176R → C.1 PublicationCorresponds to variant rs9267532dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0312551 – 55Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245417 mRNA. Translation: CAB52191.1.
AJ315545 mRNA. Translation: CAC85543.1.
AK289364 mRNA. Translation: BAF82053.1.
BA000025 Genomic DNA. Translation: BAB63385.1.
AF129756 Genomic DNA. Translation: AAF04397.1.
AL662899 Genomic DNA. Translation: CAX15050.1.
AL662899 Genomic DNA. Translation: CAI18396.1.
AL670886 Genomic DNA. Translation: CAI17803.1.
AL805934 Genomic DNA. Translation: CAI18526.1.
BX511262 Genomic DNA. Translation: CAM45828.1.
CR354443 Genomic DNA. Translation: CAQ07005.1.
CR753842 Genomic DNA. Translation: CAQ06575.1.
CR759761 Genomic DNA. Translation: CAQ10882.1.
CH471081 Genomic DNA. Translation: EAX03476.1.
CCDSiCCDS34400.1. [Q8NDX9-1]
RefSeqiNP_067044.2. NM_021221.2. [Q8NDX9-1]
UniGeneiHs.708719.

Genome annotation databases

EnsembliENST00000375864; ENSP00000365024; ENSG00000240053. [Q8NDX9-1]
ENST00000409525; ENSP00000386365; ENSG00000240053. [Q8NDX9-2]
ENST00000462244; ENSP00000418445; ENSG00000239285.
ENST00000471674; ENSP00000417055; ENSG00000241132. [Q8NDX9-1]
ENST00000480515; ENSP00000418119; ENSG00000240433. [Q8NDX9-1]
ENST00000480530; ENSP00000417822; ENSG00000241713. [Q8NDX9-1]
ENST00000484964; ENSP00000420698; ENSG00000244672. [Q8NDX9-1]
ENST00000490011; ENSP00000418217; ENSG00000239497.
GeneIDi58496.
KEGGihsa:58496.
UCSCiuc003nvt.2. human. [Q8NDX9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245417 mRNA. Translation: CAB52191.1.
AJ315545 mRNA. Translation: CAC85543.1.
AK289364 mRNA. Translation: BAF82053.1.
BA000025 Genomic DNA. Translation: BAB63385.1.
AF129756 Genomic DNA. Translation: AAF04397.1.
AL662899 Genomic DNA. Translation: CAX15050.1.
AL662899 Genomic DNA. Translation: CAI18396.1.
AL670886 Genomic DNA. Translation: CAI17803.1.
AL805934 Genomic DNA. Translation: CAI18526.1.
BX511262 Genomic DNA. Translation: CAM45828.1.
CR354443 Genomic DNA. Translation: CAQ07005.1.
CR753842 Genomic DNA. Translation: CAQ06575.1.
CR759761 Genomic DNA. Translation: CAQ10882.1.
CH471081 Genomic DNA. Translation: EAX03476.1.
CCDSiCCDS34400.1. [Q8NDX9-1]
RefSeqiNP_067044.2. NM_021221.2. [Q8NDX9-1]
UniGeneiHs.708719.

3D structure databases

ProteinModelPortaliQ8NDX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121826. 6 interactors.

PTM databases

iPTMnetiQ8NDX9.
PhosphoSitePlusiQ8NDX9.

Polymorphism and mutation databases

BioMutaiLY6G5B.
DMDMi74751234.

Proteomic databases

PaxDbiQ8NDX9.
PeptideAtlasiQ8NDX9.
PRIDEiQ8NDX9.

Protocols and materials databases

DNASUi58496.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375864; ENSP00000365024; ENSG00000240053. [Q8NDX9-1]
ENST00000409525; ENSP00000386365; ENSG00000240053. [Q8NDX9-2]
ENST00000462244; ENSP00000418445; ENSG00000239285.
ENST00000471674; ENSP00000417055; ENSG00000241132. [Q8NDX9-1]
ENST00000480515; ENSP00000418119; ENSG00000240433. [Q8NDX9-1]
ENST00000480530; ENSP00000417822; ENSG00000241713. [Q8NDX9-1]
ENST00000484964; ENSP00000420698; ENSG00000244672. [Q8NDX9-1]
ENST00000490011; ENSP00000418217; ENSG00000239497.
GeneIDi58496.
KEGGihsa:58496.
UCSCiuc003nvt.2. human. [Q8NDX9-1]

Organism-specific databases

CTDi58496.
DisGeNETi58496.
GeneCardsiLY6G5B.
HGNCiHGNC:13931. LY6G5B.
HPAiHPA048307.
MIMi610433. gene.
neXtProtiNX_Q8NDX9.
OpenTargetsiENSG00000240053.
ENSG00000240433.
ENSG00000241132.
ENSG00000241713.
ENSG00000244672.
PharmGKBiPA37826.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II7T. Eukaryota.
ENOG41113GV. LUCA.
GeneTreeiENSGT00520000060793.
HOVERGENiHBG108361.
InParanoidiQ8NDX9.
KOiK20005.
OrthoDBiEOG091G0L9V.
PhylomeDBiQ8NDX9.
TreeFamiTF338717.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124649-MONOMER.

Miscellaneous databases

GenomeRNAii58496.
PROiQ8NDX9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000239285.
CleanExiHS_LY6G5B.
ExpressionAtlasiQ8NDX9. baseline and differential.
GenevisibleiQ8NDX9. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiLY65B_HUMAN
AccessioniPrimary (citable) accession number: Q8NDX9
Secondary accession number(s): B0UXB2
, B0UZ65, B0UZP8, B7ZCA3, Q5SQ62, Q5SST3, Q9UKT0, Q9UMQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.