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Protein

Lymphocyte antigen 6 complex locus protein G5b

Gene

LY6G5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 6 complex locus protein G5b
Gene namesi
Name:LY6G5B
Synonyms:C6orf19, G5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13931. LY6G5B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37826.

Polymorphism and mutation databases

BioMutaiLY6G5B.
DMDMi74751234.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 201183Lymphocyte antigen 6 complex locus protein G5bPRO_0000318602Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 55By similarity
Disulfide bondi31 ↔ 40By similarity
Disulfide bondi47 ↔ 73By similarity
Disulfide bondi81 ↔ 98By similarity
Disulfide bondi99 ↔ 104By similarity
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence analysis
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NDX9.
PeptideAtlasiQ8NDX9.
PRIDEiQ8NDX9.

PTM databases

iPTMnetiQ8NDX9.
PhosphoSiteiQ8NDX9.

Expressioni

Gene expression databases

BgeeiQ8NDX9.
CleanExiHS_LY6G5B.
ExpressionAtlasiQ8NDX9. baseline and differential.
GenevisibleiQ8NDX9. HS.

Organism-specific databases

HPAiHPA048307.

Interactioni

Subunit structurei

Forms oligomer.1 Publication

Protein-protein interaction databases

BioGridi121826. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8NDX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 11893UPAR/Ly6Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi50 – 534Poly-Ser

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II7T. Eukaryota.
ENOG41113GV. LUCA.
GeneTreeiENSGT00520000060793.
HOVERGENiHBG108361.
InParanoidiQ8NDX9.
KOiK20005.
OrthoDBiEOG7PVWQH.
PhylomeDBiQ8NDX9.
TreeFamiTF338717.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NDX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVHMLVGVL VMVGFTVGKV PVPDIRTCHF CLVEDPSVGC ISGSEKCTIS
60 70 80 90 100
SSSLCMVITI YYDVKVRFIV RGCGQYISYR CQEKRNTYFA EYWYQAQCCQ
110 120 130 140 150
YDYCNSWSSP QLQSSLPEPH DRPLALPLSD SQIQWFYQAL NLSLPLPNFH
160 170 180 190 200
AGTEPDGLDP MVTLSLNLGL SFAELRRMYL FLNSSGLLVL PQAGLLTPHP

S
Length:201
Mass (Da):22,572
Last modified:October 1, 2002 - v1
Checksum:iE2CDFCDD5E166056
GO
Isoform 2 (identifier: Q8NDX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.

Show »
Length:146
Mass (Da):16,792
Checksum:i5C12D119A0016C22
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021D → N.
Corresponds to variant rs805267 [ dbSNP | Ensembl ].
VAR_038842
Natural varianti131 – 1311S → Y.
Corresponds to variant rs11758242 [ dbSNP | Ensembl ].
VAR_038843
Natural varianti176 – 1761R → C.1 Publication
Corresponds to variant rs9267532 [ dbSNP | Ensembl ].
VAR_038844

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5555Missing in isoform 2. 1 PublicationVSP_031255Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245417 mRNA. Translation: CAB52191.1.
AJ315545 mRNA. Translation: CAC85543.1.
AK289364 mRNA. Translation: BAF82053.1.
BA000025 Genomic DNA. Translation: BAB63385.1.
AF129756 Genomic DNA. Translation: AAF04397.1.
AL662899 Genomic DNA. Translation: CAX15050.1.
AL662899 Genomic DNA. Translation: CAI18396.1.
AL670886 Genomic DNA. Translation: CAI17803.1.
AL805934 Genomic DNA. Translation: CAI18526.1.
BX511262 Genomic DNA. Translation: CAM45828.1.
CR354443 Genomic DNA. Translation: CAQ07005.1.
CR753842 Genomic DNA. Translation: CAQ06575.1.
CR759761 Genomic DNA. Translation: CAQ10882.1.
CH471081 Genomic DNA. Translation: EAX03476.1.
CCDSiCCDS34400.1. [Q8NDX9-1]
RefSeqiNP_067044.2. NM_021221.2. [Q8NDX9-1]
UniGeneiHs.708719.

Genome annotation databases

EnsembliENST00000375864; ENSP00000365024; ENSG00000240053. [Q8NDX9-1]
ENST00000409525; ENSP00000386365; ENSG00000240053. [Q8NDX9-2]
ENST00000462244; ENSP00000418445; ENSG00000239285.
ENST00000471674; ENSP00000417055; ENSG00000241132. [Q8NDX9-1]
ENST00000480515; ENSP00000418119; ENSG00000240433. [Q8NDX9-1]
ENST00000480530; ENSP00000417822; ENSG00000241713. [Q8NDX9-1]
ENST00000484964; ENSP00000420698; ENSG00000244672. [Q8NDX9-1]
ENST00000490011; ENSP00000418217; ENSG00000239497.
GeneIDi58496.
KEGGihsa:58496.
UCSCiuc003nvt.2. human. [Q8NDX9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245417 mRNA. Translation: CAB52191.1.
AJ315545 mRNA. Translation: CAC85543.1.
AK289364 mRNA. Translation: BAF82053.1.
BA000025 Genomic DNA. Translation: BAB63385.1.
AF129756 Genomic DNA. Translation: AAF04397.1.
AL662899 Genomic DNA. Translation: CAX15050.1.
AL662899 Genomic DNA. Translation: CAI18396.1.
AL670886 Genomic DNA. Translation: CAI17803.1.
AL805934 Genomic DNA. Translation: CAI18526.1.
BX511262 Genomic DNA. Translation: CAM45828.1.
CR354443 Genomic DNA. Translation: CAQ07005.1.
CR753842 Genomic DNA. Translation: CAQ06575.1.
CR759761 Genomic DNA. Translation: CAQ10882.1.
CH471081 Genomic DNA. Translation: EAX03476.1.
CCDSiCCDS34400.1. [Q8NDX9-1]
RefSeqiNP_067044.2. NM_021221.2. [Q8NDX9-1]
UniGeneiHs.708719.

3D structure databases

ProteinModelPortaliQ8NDX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121826. 6 interactions.

PTM databases

iPTMnetiQ8NDX9.
PhosphoSiteiQ8NDX9.

Polymorphism and mutation databases

BioMutaiLY6G5B.
DMDMi74751234.

Proteomic databases

PaxDbiQ8NDX9.
PeptideAtlasiQ8NDX9.
PRIDEiQ8NDX9.

Protocols and materials databases

DNASUi58496.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375864; ENSP00000365024; ENSG00000240053. [Q8NDX9-1]
ENST00000409525; ENSP00000386365; ENSG00000240053. [Q8NDX9-2]
ENST00000462244; ENSP00000418445; ENSG00000239285.
ENST00000471674; ENSP00000417055; ENSG00000241132. [Q8NDX9-1]
ENST00000480515; ENSP00000418119; ENSG00000240433. [Q8NDX9-1]
ENST00000480530; ENSP00000417822; ENSG00000241713. [Q8NDX9-1]
ENST00000484964; ENSP00000420698; ENSG00000244672. [Q8NDX9-1]
ENST00000490011; ENSP00000418217; ENSG00000239497.
GeneIDi58496.
KEGGihsa:58496.
UCSCiuc003nvt.2. human. [Q8NDX9-1]

Organism-specific databases

CTDi58496.
GeneCardsiLY6G5B.
HGNCiHGNC:13931. LY6G5B.
HPAiHPA048307.
MIMi610433. gene.
neXtProtiNX_Q8NDX9.
PharmGKBiPA37826.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II7T. Eukaryota.
ENOG41113GV. LUCA.
GeneTreeiENSGT00520000060793.
HOVERGENiHBG108361.
InParanoidiQ8NDX9.
KOiK20005.
OrthoDBiEOG7PVWQH.
PhylomeDBiQ8NDX9.
TreeFamiTF338717.

Miscellaneous databases

GenomeRNAii58496.
PROiQ8NDX9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NDX9.
CleanExiHS_LY6G5B.
ExpressionAtlasiQ8NDX9. baseline and differential.
GenevisibleiQ8NDX9. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B)."
    Albertella M.R., Jones H., Thomson W., Olavesen M.G., Campbell R.D.
    Genomics 36:240-251(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms."
    Mallya M., Campbell R.D., Aguado B.
    Genomics 80:113-123(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT CYS-176.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands."
    Mallya M., Campbell R.D., Aguado B.
    Protein Sci. 15:2244-2256(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION, SUBUNIT.

Entry informationi

Entry nameiLY65B_HUMAN
AccessioniPrimary (citable) accession number: Q8NDX9
Secondary accession number(s): B0UXB2
, B0UZ65, B0UZP8, B7ZCA3, Q5SQ62, Q5SST3, Q9UKT0, Q9UMQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.