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Protein

Lymphocyte antigen 6 complex locus protein G5b

Gene

LY6G5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

GO - Biological processi

  • protein homooligomerization Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 6 complex locus protein G5b
Gene namesi
Name:LY6G5B
Synonyms:C6orf19, G5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000240053.8
HGNCiHGNC:13931 LY6G5B
MIMi610433 gene
neXtProtiNX_Q8NDX9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi58496
OpenTargetsiENSG00000240053
PharmGKBiPA37826

Polymorphism and mutation databases

BioMutaiLY6G5B
DMDMi74751234

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000031860219 – 201Lymphocyte antigen 6 complex locus protein G5bAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 55By similarity
Disulfide bondi31 ↔ 40By similarity
Disulfide bondi47 ↔ 73By similarity
Disulfide bondi81 ↔ 98By similarity
Disulfide bondi99 ↔ 104By similarity
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NDX9
PeptideAtlasiQ8NDX9
PRIDEiQ8NDX9

PTM databases

iPTMnetiQ8NDX9
PhosphoSitePlusiQ8NDX9

Expressioni

Gene expression databases

BgeeiENSG00000240053
CleanExiHS_LY6G5B
ExpressionAtlasiQ8NDX9 baseline and differential
GenevisibleiQ8NDX9 HS

Organism-specific databases

HPAiHPA048307

Interactioni

Subunit structurei

Forms oligomer.1 Publication

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi1218268 interactors.
STRINGi9606.ENSP00000365024

Structurei

3D structure databases

ProteinModelPortaliQ8NDX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 118UPAR/Ly6Add BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi50 – 53Poly-Ser4

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II7T Eukaryota
ENOG41113GV LUCA
GeneTreeiENSGT00520000060793
HOVERGENiHBG108361
InParanoidiQ8NDX9
KOiK20005
OrthoDBiEOG09370T2I
PhylomeDBiQ8NDX9
TreeFamiTF338717

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NDX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVHMLVGVL VMVGFTVGKV PVPDIRTCHF CLVEDPSVGC ISGSEKCTIS
60 70 80 90 100
SSSLCMVITI YYDVKVRFIV RGCGQYISYR CQEKRNTYFA EYWYQAQCCQ
110 120 130 140 150
YDYCNSWSSP QLQSSLPEPH DRPLALPLSD SQIQWFYQAL NLSLPLPNFH
160 170 180 190 200
AGTEPDGLDP MVTLSLNLGL SFAELRRMYL FLNSSGLLVL PQAGLLTPHP

S
Length:201
Mass (Da):22,572
Last modified:October 1, 2002 - v1
Checksum:iE2CDFCDD5E166056
GO
Isoform 2 (identifier: Q8NDX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.

Show »
Length:146
Mass (Da):16,792
Checksum:i5C12D119A0016C22
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038842102D → N. Corresponds to variant dbSNP:rs805267Ensembl.1
Natural variantiVAR_038843131S → Y. Corresponds to variant dbSNP:rs11758242Ensembl.1
Natural variantiVAR_038844176R → C1 PublicationCorresponds to variant dbSNP:rs9267532Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0312551 – 55Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245417 mRNA Translation: CAB52191.1
AJ315545 mRNA Translation: CAC85543.1
AK289364 mRNA Translation: BAF82053.1
BA000025 Genomic DNA Translation: BAB63385.1
AF129756 Genomic DNA Translation: AAF04397.1
AL662899 Genomic DNA No translation available.
AL670886 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
BX511262 Genomic DNA No translation available.
CR354443 Genomic DNA No translation available.
CR753842 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03476.1
CCDSiCCDS34400.1 [Q8NDX9-1]
RefSeqiNP_067044.2, NM_021221.2 [Q8NDX9-1]
UniGeneiHs.708719

Genome annotation databases

EnsembliENST00000375864; ENSP00000365024; ENSG00000240053 [Q8NDX9-1]
ENST00000409525; ENSP00000386365; ENSG00000240053 [Q8NDX9-2]
ENST00000462244; ENSP00000418445; ENSG00000239285
ENST00000471674; ENSP00000417055; ENSG00000241132 [Q8NDX9-1]
ENST00000480515; ENSP00000418119; ENSG00000240433 [Q8NDX9-1]
ENST00000480530; ENSP00000417822; ENSG00000241713 [Q8NDX9-1]
ENST00000484964; ENSP00000420698; ENSG00000244672 [Q8NDX9-1]
ENST00000490011; ENSP00000418217; ENSG00000239497
GeneIDi58496
KEGGihsa:58496
UCSCiuc003nvt.2 human [Q8NDX9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLY65B_HUMAN
AccessioniPrimary (citable) accession number: Q8NDX9
Secondary accession number(s): B0UXB2
, B0UZ65, B0UZP8, B7ZCA3, Q5SQ62, Q5SST3, Q9UKT0, Q9UMQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome