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Q8NDX6

- ZN740_HUMAN

UniProt

Q8NDX6 - ZN740_HUMAN

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Protein

Zinc finger protein 740

Gene
ZNF740, TB7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri101 – 12323C2H2-type 1Add
BLAST
Zinc fingeri129 – 15123C2H2-type 2Add
BLAST
Zinc fingeri157 – 17923C2H2-type 3; atypicalAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 740
Alternative name(s):
OriLyt TD-element-binding protein 7
Gene namesi
Name:ZNF740
Synonyms:TB7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:27465. ZNF740.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485686.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Zinc finger protein 740PRO_0000251401Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8NDX6.
PaxDbiQ8NDX6.
PRIDEiQ8NDX6.

PTM databases

PhosphoSiteiQ8NDX6.

Expressioni

Gene expression databases

BgeeiQ8NDX6.
CleanExiHS_ZNF740.
GenevestigatoriQ8NDX6.

Organism-specific databases

HPAiHPA035691.

Interactioni

Protein-protein interaction databases

BioGridi129530. 6 interactions.
IntActiQ8NDX6. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8NDX6.
SMRiQ8NDX6. Positions 103-175.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000013198.
HOVERGENiHBG061583.
InParanoidiQ8NDX6.
OMAiSRNRKDD.
OrthoDBiEOG7NKKMK.
PhylomeDBiQ8NDX6.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NDX6-1 [UniParc]FASTAAdd to Basket

« Hide

MAQASLLACE GLAGVSLVPT AASKKMMLSQ IASKQAENGE RAGSPDVLRC    50
SSQGHRKDSD KSRSRKDDDS LSEASHSKKT VKKVVVVEQN GSFQVKIPKN 100
FVCEHCFGAF RSSYHLKRHI LIHTGEKPFE CDICDMRFIQ KYHLERHKRV 150
HSGEKPYQCE RCHQCFSRTD RLLRHKRMCQ GCQSKTSDGQ FSL 193
Length:193
Mass (Da):21,857
Last modified:October 1, 2002 - v1
Checksum:i5FFDF18B6E322CBA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ316575 Genomic DNA. Translation: CAC86954.1.
AK292744 mRNA. Translation: BAF85433.1.
CH471054 Genomic DNA. Translation: EAW96673.1.
BC053557 mRNA. Translation: AAH53557.1.
CCDSiCCDS44896.1.
RefSeqiNP_001004304.1. NM_001004304.3.
UniGeneiHs.524458.

Genome annotation databases

EnsembliENST00000416904; ENSP00000409463; ENSG00000139651.
GeneIDi283337.
KEGGihsa:283337.
UCSCiuc001scb.4. human.

Polymorphism databases

DMDMi74760191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ316575 Genomic DNA. Translation: CAC86954.1 .
AK292744 mRNA. Translation: BAF85433.1 .
CH471054 Genomic DNA. Translation: EAW96673.1 .
BC053557 mRNA. Translation: AAH53557.1 .
CCDSi CCDS44896.1.
RefSeqi NP_001004304.1. NM_001004304.3.
UniGenei Hs.524458.

3D structure databases

ProteinModelPortali Q8NDX6.
SMRi Q8NDX6. Positions 103-175.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129530. 6 interactions.
IntActi Q8NDX6. 2 interactions.

PTM databases

PhosphoSitei Q8NDX6.

Polymorphism databases

DMDMi 74760191.

Proteomic databases

MaxQBi Q8NDX6.
PaxDbi Q8NDX6.
PRIDEi Q8NDX6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000416904 ; ENSP00000409463 ; ENSG00000139651 .
GeneIDi 283337.
KEGGi hsa:283337.
UCSCi uc001scb.4. human.

Organism-specific databases

CTDi 283337.
GeneCardsi GC12P053574.
HGNCi HGNC:27465. ZNF740.
HPAi HPA035691.
neXtProti NX_Q8NDX6.
PharmGKBi PA143485686.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000013198.
HOVERGENi HBG061583.
InParanoidi Q8NDX6.
OMAi SRNRKDD.
OrthoDBi EOG7NKKMK.
PhylomeDBi Q8NDX6.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 283337.
NextBioi 93823.
PROi Q8NDX6.

Gene expression databases

Bgeei Q8NDX6.
CleanExi HS_ZNF740.
Genevestigatori Q8NDX6.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Feederle R.
    Thesis (1999), University of Munich, Germany
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN740_HUMAN
AccessioniPrimary (citable) accession number: Q8NDX6
Secondary accession number(s): A8K9M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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