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Protein

Zinc finger protein 740

Gene

ZNF740

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri101 – 123C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri129 – 151C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri157 – 179C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 740
Alternative name(s):
OriLyt TD-element-binding protein 7
Gene namesi
Name:ZNF740
Synonyms:TB7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139651.10.
HGNCiHGNC:27465. ZNF740.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139651.
PharmGKBiPA143485686.

Polymorphism and mutation databases

BioMutaiZNF740.
DMDMi74760191.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002514011 – 193Zinc finger protein 740Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki34Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei44PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8NDX6.
MaxQBiQ8NDX6.
PaxDbiQ8NDX6.
PeptideAtlasiQ8NDX6.
PRIDEiQ8NDX6.

PTM databases

iPTMnetiQ8NDX6.
PhosphoSitePlusiQ8NDX6.

Expressioni

Gene expression databases

BgeeiENSG00000139651.
CleanExiHS_ZNF740.
GenevisibleiQ8NDX6. HS.

Organism-specific databases

HPAiHPA035691.

Interactioni

Protein-protein interaction databases

BioGridi129530. 7 interactors.
IntActiQ8NDX6. 4 interactors.
STRINGi9606.ENSP00000409463.

Structurei

3D structure databases

ProteinModelPortaliQ8NDX6.
SMRiQ8NDX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri101 – 123C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri129 – 151C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri157 – 179C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063238.
HOGENOMiHOG000013198.
HOVERGENiHBG061583.
InParanoidiQ8NDX6.
OMAiEPSHSKK.
OrthoDBiEOG091G0L6G.
PhylomeDBiQ8NDX6.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 3 hits.
SUPFAMiSSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q8NDX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQASLLACE GLAGVSLVPT AASKKMMLSQ IASKQAENGE RAGSPDVLRC
60 70 80 90 100
SSQGHRKDSD KSRSRKDDDS LSEASHSKKT VKKVVVVEQN GSFQVKIPKN
110 120 130 140 150
FVCEHCFGAF RSSYHLKRHI LIHTGEKPFE CDICDMRFIQ KYHLERHKRV
160 170 180 190
HSGEKPYQCE RCHQCFSRTD RLLRHKRMCQ GCQSKTSDGQ FSL
Length:193
Mass (Da):21,857
Last modified:October 1, 2002 - v1
Checksum:i5FFDF18B6E322CBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ316575 Genomic DNA. Translation: CAC86954.1.
AK292744 mRNA. Translation: BAF85433.1.
CH471054 Genomic DNA. Translation: EAW96673.1.
BC053557 mRNA. Translation: AAH53557.1.
CCDSiCCDS44896.1.
RefSeqiNP_001004304.1. NM_001004304.3.
UniGeneiHs.524458.

Genome annotation databases

EnsembliENST00000416904; ENSP00000409463; ENSG00000139651.
GeneIDi283337.
KEGGihsa:283337.
UCSCiuc001scb.5. human.

Similar proteinsi

Entry informationi

Entry nameiZN740_HUMAN
AccessioniPrimary (citable) accession number: Q8NDX6
Secondary accession number(s): A8K9M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families