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Q8NDX6

- ZN740_HUMAN

UniProt

Q8NDX6 - ZN740_HUMAN

Protein

Zinc finger protein 740

Gene

ZNF740

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri101 – 12323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri129 – 15123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri157 – 17923C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 740
    Alternative name(s):
    OriLyt TD-element-binding protein 7
    Gene namesi
    Name:ZNF740
    Synonyms:TB7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:27465. ZNF740.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485686.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 193193Zinc finger protein 740PRO_0000251401Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei44 – 441Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8NDX6.
    PaxDbiQ8NDX6.
    PRIDEiQ8NDX6.

    PTM databases

    PhosphoSiteiQ8NDX6.

    Expressioni

    Gene expression databases

    BgeeiQ8NDX6.
    CleanExiHS_ZNF740.
    GenevestigatoriQ8NDX6.

    Organism-specific databases

    HPAiHPA035691.

    Interactioni

    Protein-protein interaction databases

    BioGridi129530. 6 interactions.
    IntActiQ8NDX6. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NDX6.
    SMRiQ8NDX6. Positions 103-175.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri101 – 12323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri129 – 15123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri157 – 17923C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000013198.
    HOVERGENiHBG061583.
    InParanoidiQ8NDX6.
    OMAiSRNRKDD.
    OrthoDBiEOG7NKKMK.
    PhylomeDBiQ8NDX6.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NDX6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQASLLACE GLAGVSLVPT AASKKMMLSQ IASKQAENGE RAGSPDVLRC    50
    SSQGHRKDSD KSRSRKDDDS LSEASHSKKT VKKVVVVEQN GSFQVKIPKN 100
    FVCEHCFGAF RSSYHLKRHI LIHTGEKPFE CDICDMRFIQ KYHLERHKRV 150
    HSGEKPYQCE RCHQCFSRTD RLLRHKRMCQ GCQSKTSDGQ FSL 193
    Length:193
    Mass (Da):21,857
    Last modified:October 1, 2002 - v1
    Checksum:i5FFDF18B6E322CBA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ316575 Genomic DNA. Translation: CAC86954.1.
    AK292744 mRNA. Translation: BAF85433.1.
    CH471054 Genomic DNA. Translation: EAW96673.1.
    BC053557 mRNA. Translation: AAH53557.1.
    CCDSiCCDS44896.1.
    RefSeqiNP_001004304.1. NM_001004304.3.
    UniGeneiHs.524458.

    Genome annotation databases

    EnsembliENST00000416904; ENSP00000409463; ENSG00000139651.
    GeneIDi283337.
    KEGGihsa:283337.
    UCSCiuc001scb.4. human.

    Polymorphism databases

    DMDMi74760191.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ316575 Genomic DNA. Translation: CAC86954.1 .
    AK292744 mRNA. Translation: BAF85433.1 .
    CH471054 Genomic DNA. Translation: EAW96673.1 .
    BC053557 mRNA. Translation: AAH53557.1 .
    CCDSi CCDS44896.1.
    RefSeqi NP_001004304.1. NM_001004304.3.
    UniGenei Hs.524458.

    3D structure databases

    ProteinModelPortali Q8NDX6.
    SMRi Q8NDX6. Positions 103-175.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129530. 6 interactions.
    IntActi Q8NDX6. 2 interactions.

    PTM databases

    PhosphoSitei Q8NDX6.

    Polymorphism databases

    DMDMi 74760191.

    Proteomic databases

    MaxQBi Q8NDX6.
    PaxDbi Q8NDX6.
    PRIDEi Q8NDX6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000416904 ; ENSP00000409463 ; ENSG00000139651 .
    GeneIDi 283337.
    KEGGi hsa:283337.
    UCSCi uc001scb.4. human.

    Organism-specific databases

    CTDi 283337.
    GeneCardsi GC12P053574.
    HGNCi HGNC:27465. ZNF740.
    HPAi HPA035691.
    neXtProti NX_Q8NDX6.
    PharmGKBi PA143485686.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000013198.
    HOVERGENi HBG061583.
    InParanoidi Q8NDX6.
    OMAi SRNRKDD.
    OrthoDBi EOG7NKKMK.
    PhylomeDBi Q8NDX6.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 283337.
    NextBioi 93823.
    PROi Q8NDX6.

    Gene expression databases

    Bgeei Q8NDX6.
    CleanExi HS_ZNF740.
    Genevestigatori Q8NDX6.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Feederle R.
      Thesis (1999), University of Munich, Germany
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZN740_HUMAN
    AccessioniPrimary (citable) accession number: Q8NDX6
    Secondary accession number(s): A8K9M9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3