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Protein

Zinc finger protein 740

Gene

ZNF740

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri101 – 12323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri129 – 15123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri157 – 17923C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 740
Alternative name(s):
OriLyt TD-element-binding protein 7
Gene namesi
Name:ZNF740
Synonyms:TB7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:27465. ZNF740.

Subcellular locationi

  1. Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485686.

Polymorphism and mutation databases

BioMutaiZNF740.
DMDMi74760191.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Zinc finger protein 740PRO_0000251401Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8NDX6.
PaxDbiQ8NDX6.
PRIDEiQ8NDX6.

PTM databases

PhosphoSiteiQ8NDX6.

Expressioni

Gene expression databases

BgeeiQ8NDX6.
CleanExiHS_ZNF740.
GenevestigatoriQ8NDX6.

Organism-specific databases

HPAiHPA035691.

Interactioni

Protein-protein interaction databases

BioGridi129530. 7 interactions.
IntActiQ8NDX6. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8NDX6.
SMRiQ8NDX6. Positions 104-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri101 – 12323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri129 – 15123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri157 – 17923C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063238.
HOGENOMiHOG000013198.
HOVERGENiHBG061583.
InParanoidiQ8NDX6.
OMAiKNFICEQ.
OrthoDBiEOG7NKKMK.
PhylomeDBiQ8NDX6.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NDX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQASLLACE GLAGVSLVPT AASKKMMLSQ IASKQAENGE RAGSPDVLRC
60 70 80 90 100
SSQGHRKDSD KSRSRKDDDS LSEASHSKKT VKKVVVVEQN GSFQVKIPKN
110 120 130 140 150
FVCEHCFGAF RSSYHLKRHI LIHTGEKPFE CDICDMRFIQ KYHLERHKRV
160 170 180 190
HSGEKPYQCE RCHQCFSRTD RLLRHKRMCQ GCQSKTSDGQ FSL
Length:193
Mass (Da):21,857
Last modified:October 1, 2002 - v1
Checksum:i5FFDF18B6E322CBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ316575 Genomic DNA. Translation: CAC86954.1.
AK292744 mRNA. Translation: BAF85433.1.
CH471054 Genomic DNA. Translation: EAW96673.1.
BC053557 mRNA. Translation: AAH53557.1.
CCDSiCCDS44896.1.
RefSeqiNP_001004304.1. NM_001004304.3.
UniGeneiHs.524458.

Genome annotation databases

EnsembliENST00000416904; ENSP00000409463; ENSG00000139651.
GeneIDi283337.
KEGGihsa:283337.
UCSCiuc001scb.4. human.

Polymorphism and mutation databases

BioMutaiZNF740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ316575 Genomic DNA. Translation: CAC86954.1.
AK292744 mRNA. Translation: BAF85433.1.
CH471054 Genomic DNA. Translation: EAW96673.1.
BC053557 mRNA. Translation: AAH53557.1.
CCDSiCCDS44896.1.
RefSeqiNP_001004304.1. NM_001004304.3.
UniGeneiHs.524458.

3D structure databases

ProteinModelPortaliQ8NDX6.
SMRiQ8NDX6. Positions 104-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129530. 7 interactions.
IntActiQ8NDX6. 2 interactions.

PTM databases

PhosphoSiteiQ8NDX6.

Polymorphism and mutation databases

BioMutaiZNF740.
DMDMi74760191.

Proteomic databases

MaxQBiQ8NDX6.
PaxDbiQ8NDX6.
PRIDEiQ8NDX6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000416904; ENSP00000409463; ENSG00000139651.
GeneIDi283337.
KEGGihsa:283337.
UCSCiuc001scb.4. human.

Organism-specific databases

CTDi283337.
GeneCardsiGC12P053574.
HGNCiHGNC:27465. ZNF740.
HPAiHPA035691.
neXtProtiNX_Q8NDX6.
PharmGKBiPA143485686.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063238.
HOGENOMiHOG000013198.
HOVERGENiHBG061583.
InParanoidiQ8NDX6.
OMAiKNFICEQ.
OrthoDBiEOG7NKKMK.
PhylomeDBiQ8NDX6.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF740. human.
GenomeRNAii283337.
NextBioi93823.
PROiQ8NDX6.

Gene expression databases

BgeeiQ8NDX6.
CleanExiHS_ZNF740.
GenevestigatoriQ8NDX6.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Feederle R.
    Thesis (1999), University of Munich, Germany
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN740_HUMAN
AccessioniPrimary (citable) accession number: Q8NDX6
Secondary accession number(s): A8K9M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2002
Last modified: April 29, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.