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Protein

PH and SEC7 domain-containing protein 4

Gene

PSD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
PH and SEC7 domain-containing protein 4
Alternative name(s):
Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B
Short name:
Exchange factor for ARF6 B
Pleckstrin homology and SEC7 domain-containing protein 4
Telomeric of interleukin-1 cluster protein
Gene namesi
Name:PSD4
Synonyms:EFA6B, TIC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:19096. PSD4.

Subcellular locationi

  • Cell membrane 1 Publication

  • Note: Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures. Recruited to membranes via phosphatidylinositol phosphate-binding.

GO - Cellular componenti

  • membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134875981.

Polymorphism and mutation databases

BioMutaiPSD4.
DMDMi115515975.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10561056PH and SEC7 domain-containing protein 4PRO_0000251731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei131 – 1311PhosphoserineCombined sources
Modified residuei134 – 1341PhosphoserineCombined sources
Modified residuei143 – 1431PhosphoserineCombined sources
Modified residuei413 – 4131PhosphoserineCombined sources
Modified residuei448 – 4481PhosphoserineCombined sources
Modified residuei469 – 4691PhosphoserineBy similarity
Modified residuei491 – 4911PhosphoserineCombined sources
Modified residuei1019 – 10191PhosphoserineCombined sources
Modified residuei1022 – 10221PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NDX1.
MaxQBiQ8NDX1.
PaxDbiQ8NDX1.
PeptideAtlasiQ8NDX1.
PRIDEiQ8NDX1.

PTM databases

iPTMnetiQ8NDX1.
PhosphoSiteiQ8NDX1.

Expressioni

Tissue specificityi

Widely expressed. Highest levels of expression are found in placenta, pancreas, spleen, thymus and peripheral blood.1 Publication

Gene expression databases

BgeeiQ8NDX1.
CleanExiHS_PSD4.
ExpressionAtlasiQ8NDX1. baseline and differential.
GenevisibleiQ8NDX1. HS.

Organism-specific databases

HPAiHPA034722.
HPA034723.

Interactioni

Protein-protein interaction databases

BioGridi117094. 1 interaction.
IntActiQ8NDX1. 3 interactions.
STRINGi9606.ENSP00000245796.

Structurei

3D structure databases

ProteinModelPortaliQ8NDX1.
SMRiQ8NDX1. Positions 590-893.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini544 – 736193SEC7PROSITE-ProRule annotationAdd
BLAST
Domaini776 – 892117PHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili921 – 97656Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 SEC7 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0932. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00760000119036.
HOVERGENiHBG080313.
InParanoidiQ8NDX1.
KOiK12494.
OMAiRAELRCC.
OrthoDBiEOG7327N2.
PhylomeDBiQ8NDX1.
TreeFamiTF319755.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001605. PH_dom-spectrin-type.
IPR001849. PH_domain.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF01369. Sec7. 1 hit.
[Graphical view]
PRINTSiPR00683. SPECTRINPH.
SMARTiSM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NDX1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMGDYRLPDH PQPMEILNLY LGDSLEPHPG ECPRETCSHE DPPEPFEEQT
60 70 80 90 100
WATDPPEPTR QNVPPWGSGV ELTHLGSWVH QDGLEPCQEQ TRATDPPEST
110 120 130 140 150
RQDAPPWGSG VELTHLGSPS AQREHRQNTA SPGSPVNSHL PGSPKQNRST
160 170 180 190 200
STQVVFWAGI LQAQMCVLDL EEELEKTEGL KAGLKCCLPT PPVDLPGDTG
210 220 230 240 250
LHSSPPENED SGEDSSEPEG EGQAWLREGT PDSSPQWGAE EESMFFSNPL
260 270 280 290 300
FLASPCSENS ASGECFSWGA SDSHAGVRTG PESPATLEPP LPEDTVLWEL
310 320 330 340 350
ESEPDLGDGA AISGHCTPPF PVPIYKPHSI CWASVAAAEG APAAPPGHGE
360 370 380 390 400
SEGDRLGPAP SAAPCVDEAL TWESGCVGSD LGPAAHPVQP WASLSPEGWQ
410 420 430 440 450
RGGPFWPQVT LNSQDRDERE GGHPQESLPC TLAPCPWRSP ASSPEPSSPE
460 470 480 490 500
SESRGPGPRP SPASSQEGSP QLQHHSSGIL PKWTLDASQS SLLETDGEQP
510 520 530 540 550
SSLKKKEAGE APKPGEEVKS EGTARPAETG DVQPDIHLTS AEHENLRTPM
560 570 580 590 600
NSSWLPGSPM PQAQSPEEGQ RPPAGDKLAN GVRNNKVAWN LASRLYRLEG
610 620 630 640 650
FRKSEVAAYL QKNNDFSRAV AEEYLSFFQF GGQSLDRALR SFLQALVLSG
660 670 680 690 700
ETQERERILY QFSRRFHHCN PGIFPSVDSV HTLTCAIMLL NTDLHGQNIG
710 720 730 740 750
KSMSCQEFIT NLNGLRDGGN FPKELLKALY WSIRSEKLEW AVDEEDTARP
760 770 780 790 800
EKAQPSLPAG KMSKPFLQLA QDPTVPTYKQ GILARKMHQD ADGKKTPWGK
810 820 830 840 850
RGWKMFHTLL RGMVLYFLKQ GEDHCLEGES LVGQMVDEPV GVHHSLATPA
860 870 880 890 900
THYTKKPHVF QLRTADWRLY LFQAPTAKEM SSWIARINLA AATHSAPPFP
910 920 930 940 950
AAVGSQRRFV RPILPVGPAQ SSLEEQHRSH ENCLDAAADD LLDLQRNLPE
960 970 980 990 1000
RRGRGRELEE HRLRKEYLEY EKTRYETYVQ LLVARLHCPS DALDLWEEQL
1010 1020 1030 1040 1050
GREAGGTREP KLSLKKSHSS PSLHQDEAPT TAKVKRNISE RRTYRKIIPK

RNRNQL
Length:1,056
Mass (Da):116,249
Last modified:October 3, 2006 - v2
Checksum:iC1FC0F22DB596116
GO
Isoform 2 (identifier: Q8NDX1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     417-444: Missing.
     820-820: Missing.

Show »
Length:1,027
Mass (Da):113,134
Checksum:i7BA4FE0FDF818385
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71L → F (PubMed:12082148).Curated
Sequence conflicti7 – 71L → F (Ref. 2) Curated
Sequence conflicti8 – 81P → L (Ref. 2) Curated
Sequence conflicti124 – 1241E → D in AAH35307 (PubMed:15489334).Curated
Sequence conflicti410 – 4101T → I in AAD00107 (Ref. 2) Curated
Sequence conflicti428 – 4281L → F in AAD00107 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831G → R.
Corresponds to variant rs1562277 [ dbSNP | Ensembl ].
VAR_051921
Natural varianti233 – 2331S → P.
Corresponds to variant rs12472091 [ dbSNP | Ensembl ].
VAR_051922
Natural varianti269 – 2691G → A.4 Publications
Corresponds to variant rs4849167 [ dbSNP | Ensembl ].
VAR_027712
Natural varianti637 – 6371R → Q.
Corresponds to variant rs45487591 [ dbSNP | Ensembl ].
VAR_051923
Natural varianti658 – 6581I → V.
Corresponds to variant rs45574835 [ dbSNP | Ensembl ].
VAR_051924

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei417 – 44428Missing in isoform 2. 1 PublicationVSP_020772Add
BLAST
Alternative sequencei820 – 8201Missing in isoform 2. 1 PublicationVSP_020773

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ459781 mRNA. Translation: CAD30842.1.
U63127 mRNA. Translation: AAD00107.1.
DQ452296 Genomic DNA. Translation: ABD96831.1.
AK290045 mRNA. Translation: BAF82734.1.
AC016683 Genomic DNA. Translation: AAX88879.1.
CH471217 Genomic DNA. Translation: EAW73626.1.
BC035307 mRNA. Translation: AAH35307.1.
BC073151 mRNA. Translation: AAH73151.1.
CCDSiCCDS33276.1. [Q8NDX1-1]
RefSeqiNP_036587.2. NM_012455.2. [Q8NDX1-1]
XP_005263691.1. XM_005263634.2. [Q8NDX1-1]
UniGeneiHs.516306.

Genome annotation databases

EnsembliENST00000245796; ENSP00000245796; ENSG00000125637. [Q8NDX1-1]
ENST00000441564; ENSP00000413997; ENSG00000125637. [Q8NDX1-2]
GeneIDi23550.
KEGGihsa:23550.
UCSCiuc002tjc.4. human. [Q8NDX1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ459781 mRNA. Translation: CAD30842.1.
U63127 mRNA. Translation: AAD00107.1.
DQ452296 Genomic DNA. Translation: ABD96831.1.
AK290045 mRNA. Translation: BAF82734.1.
AC016683 Genomic DNA. Translation: AAX88879.1.
CH471217 Genomic DNA. Translation: EAW73626.1.
BC035307 mRNA. Translation: AAH35307.1.
BC073151 mRNA. Translation: AAH73151.1.
CCDSiCCDS33276.1. [Q8NDX1-1]
RefSeqiNP_036587.2. NM_012455.2. [Q8NDX1-1]
XP_005263691.1. XM_005263634.2. [Q8NDX1-1]
UniGeneiHs.516306.

3D structure databases

ProteinModelPortaliQ8NDX1.
SMRiQ8NDX1. Positions 590-893.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117094. 1 interaction.
IntActiQ8NDX1. 3 interactions.
STRINGi9606.ENSP00000245796.

PTM databases

iPTMnetiQ8NDX1.
PhosphoSiteiQ8NDX1.

Polymorphism and mutation databases

BioMutaiPSD4.
DMDMi115515975.

Proteomic databases

EPDiQ8NDX1.
MaxQBiQ8NDX1.
PaxDbiQ8NDX1.
PeptideAtlasiQ8NDX1.
PRIDEiQ8NDX1.

Protocols and materials databases

DNASUi23550.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245796; ENSP00000245796; ENSG00000125637. [Q8NDX1-1]
ENST00000441564; ENSP00000413997; ENSG00000125637. [Q8NDX1-2]
GeneIDi23550.
KEGGihsa:23550.
UCSCiuc002tjc.4. human. [Q8NDX1-1]

Organism-specific databases

CTDi23550.
GeneCardsiPSD4.
H-InvDBHIX0002390.
HGNCiHGNC:19096. PSD4.
HPAiHPA034722.
HPA034723.
MIMi614442. gene.
neXtProtiNX_Q8NDX1.
PharmGKBiPA134875981.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0932. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00760000119036.
HOVERGENiHBG080313.
InParanoidiQ8NDX1.
KOiK12494.
OMAiRAELRCC.
OrthoDBiEOG7327N2.
PhylomeDBiQ8NDX1.
TreeFamiTF319755.

Miscellaneous databases

ChiTaRSiPSD4. human.
GenomeRNAii23550.
PROiQ8NDX1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NDX1.
CleanExiHS_PSD4.
ExpressionAtlasiQ8NDX1. baseline and differential.
GenevisibleiQ8NDX1. HS.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001605. PH_dom-spectrin-type.
IPR001849. PH_domain.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF01369. Sec7. 1 hit.
[Graphical view]
PRINTSiPR00683. SPECTRINPH.
SMARTiSM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A conserved carboxy-terminal domain of EFA6-family ARF6-guanine nucleotide exchange factors induces lengthening of microvilli-like membrane protrusions."
    Derrien V., Couillault C., Franco M., Martineau S., Montcourrier P., Houlgatte R., Chavrier P.
    J. Cell Sci. 115:2867-2879(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Placenta.
  2. "A novel human gene (TIC) telomeric of interleukin-1 cluster on chromosome 2q13, homologous to the S.cerevisiae gene SEC 7."
    Klenka T.P., Herbst R., Nicklin M.J.H.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Peripheral blood and Placenta.
  3. SeattleSNPs variation discovery resource
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-269.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-269.
    Tissue: Hippocampus.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-269.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-269.
    Tissue: Blood and Lymph.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-491, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation."
    Paul P., van den Hoorn T., Jongsma M.L., Bakker M.J., Hengeveld R., Janssen L., Cresswell P., Egan D.A., van Ham M., Ten Brinke A., Ovaa H., Beijersbergen R.L., Kuijl C., Neefjes J.
    Cell 145:268-283(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH VARIOUS PHOSPHATIDYLINOSITOL PHOSPHATE SPECIES.
  10. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131; SER-134; SER-143; SER-413 AND SER-1019, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPSD4_HUMAN
AccessioniPrimary (citable) accession number: Q8NDX1
Secondary accession number(s): A6NEG7
, A8K1Y0, O95621, Q4ZG34, Q6GPH8, Q8IYP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 6, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.