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Protein

Tetratricopeptide repeat protein 21A

Gene

TTC21A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 21A
Short name:
TPR repeat protein 21A
Alternative name(s):
Stress-inducible protein 2
Gene namesi
Name:TTC21A
Synonyms:STI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30761. TTC21A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134915959.

Polymorphism and mutation databases

BioMutaiTTC21A.
DMDMi296453007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13201320Tetratricopeptide repeat protein 21APRO_0000291915Add
BLAST

Proteomic databases

EPDiQ8NDW8.
PaxDbiQ8NDW8.
PeptideAtlasiQ8NDW8.
PRIDEiQ8NDW8.
TopDownProteomicsiQ8NDW8-6. [Q8NDW8-6]

PTM databases

iPTMnetiQ8NDW8.
PhosphoSiteiQ8NDW8.

Expressioni

Tissue specificityi

Strongly expressed in testis.1 Publication

Gene expression databases

BgeeiQ8NDW8.
CleanExiHS_TTC21A.
ExpressionAtlasiQ8NDW8. baseline and differential.
GenevisibleiQ8NDW8. HS.

Organism-specific databases

HPAiHPA035510.
HPA035511.

Interactioni

Protein-protein interaction databases

BioGridi128260. 3 interactions.
STRINGi9606.ENSP00000398211.

Structurei

3D structure databases

ProteinModelPortaliQ8NDW8.
SMRiQ8NDW8. Positions 198-247, 731-825, 891-1001, 1275-1301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 3835TPR 1Add
BLAST
Repeati110 – 14334TPR 2Add
BLAST
Repeati146 – 18035TPR 3Add
BLAST
Repeati181 – 21333TPR 4Add
BLAST
Repeati215 – 24733TPR 5Add
BLAST
Repeati334 – 36734TPR 6Add
BLAST
Repeati502 – 53433TPR 7Add
BLAST
Repeati572 – 60534TPR 8Add
BLAST
Repeati728 – 76134TPR 9Add
BLAST
Repeati762 – 79534TPR 10Add
BLAST
Repeati797 – 82832TPR 11Add
BLAST
Repeati837 – 86933TPR 12Add
BLAST
Repeati889 – 92234TPR 13Add
BLAST
Repeati924 – 95633TPR 14Add
BLAST
Repeati957 – 99034TPR 15Add
BLAST
Repeati1028 – 106134TPR 16Add
BLAST
Repeati1201 – 123434TPR 17Add
BLAST
Repeati1236 – 126833TPR 18Add
BLAST
Repeati1270 – 130334TPR 19Add
BLAST

Sequence similaritiesi

Belongs to the TTC21 family.Curated
Contains 19 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IEX1. Eukaryota.
ENOG410XV69. LUCA.
GeneTreeiENSGT00390000005979.
HOVERGENiHBG108607.
InParanoidiQ8NDW8.
OMAiMVQICLN.
OrthoDBiEOG7TQV01.
PhylomeDBiQ8NDW8.
TreeFamiTF314664.

Family and domain databases

Gene3Di1.25.40.10. 7 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 13 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 6 hits.
PROSITEiPS50005. TPR. 9 hits.
PS50293. TPR_REGION. 4 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NDW8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSNDSSLMA GIIYYSQEKY FHHVQQAAAV GLEKFSNDPV LKFFKAYGVL
60 70 80 90 100
KEEHIQDAIS DLESIRHHPD VSLCSTMALI YAHKRCEIID REAIQELEYS
110 120 130 140 150
LKEIRKTVSG TALYYAGLFL WLIGRHDKAK EYIDRMLKIS RGFREAYVLR
160 170 180 190 200
GWVDLTSDKP HTAKKAIEYL EQGIQDTKDV LGLMGKAMYF MMQQNYSEAL
210 220 230 240 250
EVVNQITVTS GSFLPALVLK MQLFLARQDW EQTVEMGHRI LEKDESNIDA
260 270 280 290 300
CQILTVHELA REGNMTTVSS LKTQKATNHV RNLIKALETR EPENPSLHLK
310 320 330 340 350
KIIVVSRLCG SHQVILGLVC SFIERTFMAT PSYVHVATEL GYLFILKNQV
360 370 380 390 400
KEALLWYSEA MKLDKDGMAG LTGIILCHIL EGHLEEAEYR LEFLKEVQKS
410 420 430 440 450
LGKSEVLIFL QALLMSRKHK GEEETTALLK EAVELHFSSM QGIPLGSEYF
460 470 480 490 500
EKLDPYFLVC IAKEYLLFCP KQPRLPGQIV SPLLKQVAVI LNPVVKAAPA
510 520 530 540 550
LIDPLYLMAQ VRYYSELENA QSILQRCLEL DPASVDAHLL MCQIYLAQGN
560 570 580 590 600
FGMCFHCLEL GVSHNFQVRD HPLYHLIKAR ALNKAGDYPE AIKTLKMVIK
610 620 630 640 650
LPALKKEEGR KFLRPSVQPS QRASILLELV EALRLNGELH EATKVMQDTI
660 670 680 690 700
NEFGGTPEEN RITIANVDLV LSKGNVDVAL NMLRNILPKQ SCYMEAREKM
710 720 730 740 750
ANIYLQTLRD RRLYIRCYRE LCEHLPGPHT SLLLGDALMS ILEPEKALEV
760 770 780 790 800
YDEAYRQNPH DASLASRIGH AYVKAHQYTE AIEYYEAAQK INGQDFLCCD
810 820 830 840 850
LGKLLLKLKK VNKAEKVLKQ ALEHDIVQDI PSMMNDVKCL LLLAKVYKSH
860 870 880 890 900
KKEAVIETLN KALDLQSRIL KRVPLEQPEM IPSQKQLAAS ICIQFAEHYL
910 920 930 940 950
AEKEYDKAVQ SYKDVFSYLP TDNKVMLELA QLYLLQGHLD LCEQHCAILL
960 970 980 990 1000
QTEQNHETAS VLMADLMFRK QKHEAAINLY HQVLEKAPDN FLVLHKLIDL
1010 1020 1030 1040 1050
LRRSGKLEDI PAFFELAKKV SSRVPLEPGF NYCRGIYCWH IGQPNEALKF
1060 1070 1080 1090 1100
LNKARKDSTW GQSAIYHMVQ ICLNPDNEVV GGEAFENQGA ESNYMEKKEL
1110 1120 1130 1140 1150
EQQGVSTAEK LLREFYPHSD SSQTQLRLLQ GLCRLATREK ANMEAALGSF
1160 1170 1180 1190 1200
IQIAQAEKDS VPALLALAQA YVFLKQIPKA RMQLKRLAKT PWVLSEAEDL
1210 1220 1230 1240 1250
EKSWLLLADI YCQGSKFDLA LELLRRCVQY NKSCYKAYEY MGFIMEKEQS
1260 1270 1280 1290 1300
YKDAVTNYKL AWKYSHHANP AIGFKLAFNY LKDKKFVEAI EICNDVLREH
1310 1320
PDYPKIREEI LEKARRSLRP
Length:1,320
Mass (Da):150,944
Last modified:May 18, 2010 - v3
Checksum:iCFB949A8E2B702DE
GO
Isoform 3 (identifier: Q8NDW8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-879: Missing.

Note: No experimental confirmation available.
Show »
Length:441
Mass (Da):50,905
Checksum:i102EA3A89D2111D8
GO
Isoform 5 (identifier: Q8NDW8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-275: Missing.
     386-396: Missing.
     515-515: S → SG

Note: No experimental confirmation available.
Show »
Length:1,302
Mass (Da):148,721
Checksum:i659D1D9077679B39
GO
Isoform 6 (identifier: Q8NDW8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-187: Missing.
     268-275: Missing.
     515-515: S → SG

Note: No experimental confirmation available.
Show »
Length:1,272
Mass (Da):145,558
Checksum:iC748B6FFC7FAC0CA
GO
Isoform 7 (identifier: Q8NDW8-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     515-515: S → SG

Note: No experimental confirmation available.
Show »
Length:1,321
Mass (Da):151,001
Checksum:iC3522C1E399E1700
GO

Sequence cautioni

The sequence BAC04129.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531V → G in CAD31647 (PubMed:12543795).Curated
Sequence conflicti174 – 1741I → T in BAG63718 (PubMed:14702039).Curated
Sequence conflicti802 – 8021G → D in BAG63755 (PubMed:14702039).Curated
Sequence conflicti803 – 8031K → E in CAD31647 (PubMed:12543795).Curated
Sequence conflicti838 – 8381K → R in BAG63718 (PubMed:14702039).Curated
Sequence conflicti1095 – 10951M → T in CAD31647 (PubMed:12543795).Curated
Sequence conflicti1165 – 11651L → P in BAC04129 (PubMed:14702039).Curated
Sequence conflicti1291 – 12911E → K in BAG63755 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti91 – 911R → Q.
Corresponds to variant rs1112438 [ dbSNP | Ensembl ].
VAR_032879
Natural varianti108 – 1081V → L.
Corresponds to variant rs17855763 [ dbSNP | Ensembl ].
VAR_032880
Natural varianti290 – 2901R → K.
Corresponds to variant rs1274972 [ dbSNP | Ensembl ].
VAR_032881
Natural varianti293 – 2931E → K.
Corresponds to variant rs1274971 [ dbSNP | Ensembl ].
VAR_032882
Natural varianti622 – 6221R → W.
Corresponds to variant rs35581078 [ dbSNP | Ensembl ].
VAR_032883
Natural varianti719 – 7191R → H.
Corresponds to variant rs9861353 [ dbSNP | Ensembl ].
VAR_059861
Natural varianti719 – 7191R → Q.
Corresponds to variant rs9861353 [ dbSNP | Ensembl ].
VAR_032884
Natural varianti1055 – 10551R → L.1 Publication
Corresponds to variant rs35934336 [ dbSNP | Ensembl ].
VAR_032885
Natural varianti1160 – 11601S → R.
Corresponds to variant rs34201693 [ dbSNP | Ensembl ].
VAR_032886
Natural varianti1316 – 13161R → K.1 Publication
Corresponds to variant rs704959 [ dbSNP | Ensembl ].
VAR_032887

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 879879Missing in isoform 3. 1 PublicationVSP_026297Add
BLAST
Alternative sequencei147 – 18741Missing in isoform 6. CuratedVSP_038428Add
BLAST
Alternative sequencei268 – 2758Missing in isoform 5 and isoform 6. 1 PublicationVSP_038429
Alternative sequencei386 – 39611Missing in isoform 5. 1 PublicationVSP_038430Add
BLAST
Alternative sequencei515 – 5151S → SG in isoform 5, isoform 6 and isoform 7. 1 PublicationVSP_038431

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487015 mRNA. Translation: CAD31647.1.
AK093313 mRNA. Translation: BAC04129.1. Different initiation.
AK098528 mRNA. Translation: BAC05323.1.
AK302408 mRNA. Translation: BAG63718.1.
AK302465 mRNA. Translation: BAG63755.1.
AC092053 Genomic DNA. No translation available.
AC138124 Genomic DNA. No translation available.
CCDSiCCDS43068.2. [Q8NDW8-6]
CCDS46800.1. [Q8NDW8-1]
RefSeqiNP_001098983.2. NM_001105513.2. [Q8NDW8-6]
NP_665698.2. NM_145755.2. [Q8NDW8-1]
UniGeneiHs.443935.

Genome annotation databases

EnsembliENST00000431162; ENSP00000398211; ENSG00000168026. [Q8NDW8-1]
ENST00000440121; ENSP00000410882; ENSG00000168026. [Q8NDW8-6]
GeneIDi199223.
KEGGihsa:199223.
UCSCiuc003cjc.3. human. [Q8NDW8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487015 mRNA. Translation: CAD31647.1.
AK093313 mRNA. Translation: BAC04129.1. Different initiation.
AK098528 mRNA. Translation: BAC05323.1.
AK302408 mRNA. Translation: BAG63718.1.
AK302465 mRNA. Translation: BAG63755.1.
AC092053 Genomic DNA. No translation available.
AC138124 Genomic DNA. No translation available.
CCDSiCCDS43068.2. [Q8NDW8-6]
CCDS46800.1. [Q8NDW8-1]
RefSeqiNP_001098983.2. NM_001105513.2. [Q8NDW8-6]
NP_665698.2. NM_145755.2. [Q8NDW8-1]
UniGeneiHs.443935.

3D structure databases

ProteinModelPortaliQ8NDW8.
SMRiQ8NDW8. Positions 198-247, 731-825, 891-1001, 1275-1301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128260. 3 interactions.
STRINGi9606.ENSP00000398211.

PTM databases

iPTMnetiQ8NDW8.
PhosphoSiteiQ8NDW8.

Polymorphism and mutation databases

BioMutaiTTC21A.
DMDMi296453007.

Proteomic databases

EPDiQ8NDW8.
PaxDbiQ8NDW8.
PeptideAtlasiQ8NDW8.
PRIDEiQ8NDW8.
TopDownProteomicsiQ8NDW8-6. [Q8NDW8-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431162; ENSP00000398211; ENSG00000168026. [Q8NDW8-1]
ENST00000440121; ENSP00000410882; ENSG00000168026. [Q8NDW8-6]
GeneIDi199223.
KEGGihsa:199223.
UCSCiuc003cjc.3. human. [Q8NDW8-1]

Organism-specific databases

CTDi199223.
GeneCardsiTTC21A.
HGNCiHGNC:30761. TTC21A.
HPAiHPA035510.
HPA035511.
MIMi611430. gene.
neXtProtiNX_Q8NDW8.
PharmGKBiPA134915959.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEX1. Eukaryota.
ENOG410XV69. LUCA.
GeneTreeiENSGT00390000005979.
HOVERGENiHBG108607.
InParanoidiQ8NDW8.
OMAiMVQICLN.
OrthoDBiEOG7TQV01.
PhylomeDBiQ8NDW8.
TreeFamiTF314664.

Miscellaneous databases

ChiTaRSiTTC21A. human.
GenomeRNAii199223.
PROiQ8NDW8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NDW8.
CleanExiHS_TTC21A.
ExpressionAtlasiQ8NDW8. baseline and differential.
GenevisibleiQ8NDW8. HS.

Family and domain databases

Gene3Di1.25.40.10. 7 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 13 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 6 hits.
PROSITEiPS50005. TPR. 9 hits.
PS50293. TPR_REGION. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies."
    Protopopov A., Kashuba V., Zabarovska V.I., Muravenko O.V., Lerman M.I., Klein G., Zabarovsky E.R.
    Cancer Res. 63:404-412(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT LYS-1316.
    Tissue: Pancreas.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 440-1320 (ISOFORMS 5/6/7), VARIANT LEU-1055.
    Tissue: Testis.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTT21A_HUMAN
AccessioniPrimary (citable) accession number: Q8NDW8
Secondary accession number(s): A1L388
, B4DYF6, B4DYJ3, D3YTE7, D4PHA5, Q6P5W8, Q8N7G5, Q8NA02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.