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Protein

Tetratricopeptide repeat protein 21A

Gene

TTC21A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168026-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 21A
Short name:
TPR repeat protein 21A
Alternative name(s):
Stress-inducible protein 2
Gene namesi
Name:TTC21A
Synonyms:STI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30761. TTC21A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi199223.
OpenTargetsiENSG00000168026.
PharmGKBiPA134915959.

Polymorphism and mutation databases

BioMutaiTTC21A.
DMDMi296453007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002919151 – 1320Tetratricopeptide repeat protein 21AAdd BLAST1320

Proteomic databases

PaxDbiQ8NDW8.
PeptideAtlasiQ8NDW8.
PRIDEiQ8NDW8.
TopDownProteomicsiQ8NDW8-6. [Q8NDW8-6]

PTM databases

iPTMnetiQ8NDW8.
PhosphoSitePlusiQ8NDW8.

Expressioni

Tissue specificityi

Strongly expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000168026.
CleanExiHS_TTC21A.
ExpressionAtlasiQ8NDW8. baseline and differential.
GenevisibleiQ8NDW8. HS.

Organism-specific databases

HPAiHPA035510.
HPA035511.

Interactioni

Protein-protein interaction databases

BioGridi128260. 3 interactors.
IntActiQ8NDW8. 3 interactors.
STRINGi9606.ENSP00000398211.

Structurei

3D structure databases

ProteinModelPortaliQ8NDW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 38TPR 1Add BLAST35
Repeati110 – 143TPR 2Add BLAST34
Repeati146 – 180TPR 3Add BLAST35
Repeati181 – 213TPR 4Add BLAST33
Repeati215 – 247TPR 5Add BLAST33
Repeati334 – 367TPR 6Add BLAST34
Repeati502 – 534TPR 7Add BLAST33
Repeati572 – 605TPR 8Add BLAST34
Repeati728 – 761TPR 9Add BLAST34
Repeati762 – 795TPR 10Add BLAST34
Repeati797 – 828TPR 11Add BLAST32
Repeati837 – 869TPR 12Add BLAST33
Repeati889 – 922TPR 13Add BLAST34
Repeati924 – 956TPR 14Add BLAST33
Repeati957 – 990TPR 15Add BLAST34
Repeati1028 – 1061TPR 16Add BLAST34
Repeati1201 – 1234TPR 17Add BLAST34
Repeati1236 – 1268TPR 18Add BLAST33
Repeati1270 – 1303TPR 19Add BLAST34

Sequence similaritiesi

Belongs to the TTC21 family.Curated
Contains 19 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IEX1. Eukaryota.
ENOG410XV69. LUCA.
GeneTreeiENSGT00390000005979.
HOVERGENiHBG108607.
InParanoidiQ8NDW8.
OMAiMVQICLN.
OrthoDBiEOG091G00TY.
PhylomeDBiQ8NDW8.
TreeFamiTF314664.

Family and domain databases

Gene3Di1.25.40.10. 6 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 13 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 6 hits.
PROSITEiPS50005. TPR. 9 hits.
PS50293. TPR_REGION. 4 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NDW8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSNDSSLMA GIIYYSQEKY FHHVQQAAAV GLEKFSNDPV LKFFKAYGVL
60 70 80 90 100
KEEHIQDAIS DLESIRHHPD VSLCSTMALI YAHKRCEIID REAIQELEYS
110 120 130 140 150
LKEIRKTVSG TALYYAGLFL WLIGRHDKAK EYIDRMLKIS RGFREAYVLR
160 170 180 190 200
GWVDLTSDKP HTAKKAIEYL EQGIQDTKDV LGLMGKAMYF MMQQNYSEAL
210 220 230 240 250
EVVNQITVTS GSFLPALVLK MQLFLARQDW EQTVEMGHRI LEKDESNIDA
260 270 280 290 300
CQILTVHELA REGNMTTVSS LKTQKATNHV RNLIKALETR EPENPSLHLK
310 320 330 340 350
KIIVVSRLCG SHQVILGLVC SFIERTFMAT PSYVHVATEL GYLFILKNQV
360 370 380 390 400
KEALLWYSEA MKLDKDGMAG LTGIILCHIL EGHLEEAEYR LEFLKEVQKS
410 420 430 440 450
LGKSEVLIFL QALLMSRKHK GEEETTALLK EAVELHFSSM QGIPLGSEYF
460 470 480 490 500
EKLDPYFLVC IAKEYLLFCP KQPRLPGQIV SPLLKQVAVI LNPVVKAAPA
510 520 530 540 550
LIDPLYLMAQ VRYYSELENA QSILQRCLEL DPASVDAHLL MCQIYLAQGN
560 570 580 590 600
FGMCFHCLEL GVSHNFQVRD HPLYHLIKAR ALNKAGDYPE AIKTLKMVIK
610 620 630 640 650
LPALKKEEGR KFLRPSVQPS QRASILLELV EALRLNGELH EATKVMQDTI
660 670 680 690 700
NEFGGTPEEN RITIANVDLV LSKGNVDVAL NMLRNILPKQ SCYMEAREKM
710 720 730 740 750
ANIYLQTLRD RRLYIRCYRE LCEHLPGPHT SLLLGDALMS ILEPEKALEV
760 770 780 790 800
YDEAYRQNPH DASLASRIGH AYVKAHQYTE AIEYYEAAQK INGQDFLCCD
810 820 830 840 850
LGKLLLKLKK VNKAEKVLKQ ALEHDIVQDI PSMMNDVKCL LLLAKVYKSH
860 870 880 890 900
KKEAVIETLN KALDLQSRIL KRVPLEQPEM IPSQKQLAAS ICIQFAEHYL
910 920 930 940 950
AEKEYDKAVQ SYKDVFSYLP TDNKVMLELA QLYLLQGHLD LCEQHCAILL
960 970 980 990 1000
QTEQNHETAS VLMADLMFRK QKHEAAINLY HQVLEKAPDN FLVLHKLIDL
1010 1020 1030 1040 1050
LRRSGKLEDI PAFFELAKKV SSRVPLEPGF NYCRGIYCWH IGQPNEALKF
1060 1070 1080 1090 1100
LNKARKDSTW GQSAIYHMVQ ICLNPDNEVV GGEAFENQGA ESNYMEKKEL
1110 1120 1130 1140 1150
EQQGVSTAEK LLREFYPHSD SSQTQLRLLQ GLCRLATREK ANMEAALGSF
1160 1170 1180 1190 1200
IQIAQAEKDS VPALLALAQA YVFLKQIPKA RMQLKRLAKT PWVLSEAEDL
1210 1220 1230 1240 1250
EKSWLLLADI YCQGSKFDLA LELLRRCVQY NKSCYKAYEY MGFIMEKEQS
1260 1270 1280 1290 1300
YKDAVTNYKL AWKYSHHANP AIGFKLAFNY LKDKKFVEAI EICNDVLREH
1310 1320
PDYPKIREEI LEKARRSLRP
Length:1,320
Mass (Da):150,944
Last modified:May 18, 2010 - v3
Checksum:iCFB949A8E2B702DE
GO
Isoform 3 (identifier: Q8NDW8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-879: Missing.

Note: No experimental confirmation available.
Show »
Length:441
Mass (Da):50,905
Checksum:i102EA3A89D2111D8
GO
Isoform 5 (identifier: Q8NDW8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-275: Missing.
     386-396: Missing.
     515-515: S → SG

Note: No experimental confirmation available.
Show »
Length:1,302
Mass (Da):148,721
Checksum:i659D1D9077679B39
GO
Isoform 6 (identifier: Q8NDW8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-187: Missing.
     268-275: Missing.
     515-515: S → SG

Note: No experimental confirmation available.
Show »
Length:1,272
Mass (Da):145,558
Checksum:iC748B6FFC7FAC0CA
GO
Isoform 7 (identifier: Q8NDW8-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     515-515: S → SG

Note: No experimental confirmation available.
Show »
Length:1,321
Mass (Da):151,001
Checksum:iC3522C1E399E1700
GO

Sequence cautioni

The sequence BAC04129 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153V → G in CAD31647 (PubMed:12543795).Curated1
Sequence conflicti174I → T in BAG63718 (PubMed:14702039).Curated1
Sequence conflicti802G → D in BAG63755 (PubMed:14702039).Curated1
Sequence conflicti803K → E in CAD31647 (PubMed:12543795).Curated1
Sequence conflicti838K → R in BAG63718 (PubMed:14702039).Curated1
Sequence conflicti1095M → T in CAD31647 (PubMed:12543795).Curated1
Sequence conflicti1165L → P in BAC04129 (PubMed:14702039).Curated1
Sequence conflicti1291E → K in BAG63755 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03287991R → Q.Corresponds to variant rs1112438dbSNPEnsembl.1
Natural variantiVAR_032880108V → L.Corresponds to variant rs17855763dbSNPEnsembl.1
Natural variantiVAR_032881290R → K.Corresponds to variant rs1274972dbSNPEnsembl.1
Natural variantiVAR_032882293E → K.Corresponds to variant rs1274971dbSNPEnsembl.1
Natural variantiVAR_032883622R → W.Corresponds to variant rs35581078dbSNPEnsembl.1
Natural variantiVAR_059861719R → H.Corresponds to variant rs9861353dbSNPEnsembl.1
Natural variantiVAR_032884719R → Q.Corresponds to variant rs9861353dbSNPEnsembl.1
Natural variantiVAR_0328851055R → L.1 PublicationCorresponds to variant rs35934336dbSNPEnsembl.1
Natural variantiVAR_0328861160S → R.Corresponds to variant rs34201693dbSNPEnsembl.1
Natural variantiVAR_0328871316R → K.1 PublicationCorresponds to variant rs704959dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0262971 – 879Missing in isoform 3. 1 PublicationAdd BLAST879
Alternative sequenceiVSP_038428147 – 187Missing in isoform 6. CuratedAdd BLAST41
Alternative sequenceiVSP_038429268 – 275Missing in isoform 5 and isoform 6. 1 Publication8
Alternative sequenceiVSP_038430386 – 396Missing in isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_038431515S → SG in isoform 5, isoform 6 and isoform 7. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487015 mRNA. Translation: CAD31647.1.
AK093313 mRNA. Translation: BAC04129.1. Different initiation.
AK098528 mRNA. Translation: BAC05323.1.
AK302408 mRNA. Translation: BAG63718.1.
AK302465 mRNA. Translation: BAG63755.1.
AC092053 Genomic DNA. No translation available.
AC138124 Genomic DNA. No translation available.
CCDSiCCDS43068.2. [Q8NDW8-6]
CCDS46800.1. [Q8NDW8-1]
RefSeqiNP_001098983.2. NM_001105513.2. [Q8NDW8-6]
NP_665698.2. NM_145755.2. [Q8NDW8-1]
UniGeneiHs.443935.

Genome annotation databases

EnsembliENST00000431162; ENSP00000398211; ENSG00000168026. [Q8NDW8-1]
ENST00000440121; ENSP00000410882; ENSG00000168026. [Q8NDW8-6]
GeneIDi199223.
KEGGihsa:199223.
UCSCiuc003cjc.3. human. [Q8NDW8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487015 mRNA. Translation: CAD31647.1.
AK093313 mRNA. Translation: BAC04129.1. Different initiation.
AK098528 mRNA. Translation: BAC05323.1.
AK302408 mRNA. Translation: BAG63718.1.
AK302465 mRNA. Translation: BAG63755.1.
AC092053 Genomic DNA. No translation available.
AC138124 Genomic DNA. No translation available.
CCDSiCCDS43068.2. [Q8NDW8-6]
CCDS46800.1. [Q8NDW8-1]
RefSeqiNP_001098983.2. NM_001105513.2. [Q8NDW8-6]
NP_665698.2. NM_145755.2. [Q8NDW8-1]
UniGeneiHs.443935.

3D structure databases

ProteinModelPortaliQ8NDW8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128260. 3 interactors.
IntActiQ8NDW8. 3 interactors.
STRINGi9606.ENSP00000398211.

PTM databases

iPTMnetiQ8NDW8.
PhosphoSitePlusiQ8NDW8.

Polymorphism and mutation databases

BioMutaiTTC21A.
DMDMi296453007.

Proteomic databases

PaxDbiQ8NDW8.
PeptideAtlasiQ8NDW8.
PRIDEiQ8NDW8.
TopDownProteomicsiQ8NDW8-6. [Q8NDW8-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431162; ENSP00000398211; ENSG00000168026. [Q8NDW8-1]
ENST00000440121; ENSP00000410882; ENSG00000168026. [Q8NDW8-6]
GeneIDi199223.
KEGGihsa:199223.
UCSCiuc003cjc.3. human. [Q8NDW8-1]

Organism-specific databases

CTDi199223.
DisGeNETi199223.
GeneCardsiTTC21A.
HGNCiHGNC:30761. TTC21A.
HPAiHPA035510.
HPA035511.
MIMi611430. gene.
neXtProtiNX_Q8NDW8.
OpenTargetsiENSG00000168026.
PharmGKBiPA134915959.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEX1. Eukaryota.
ENOG410XV69. LUCA.
GeneTreeiENSGT00390000005979.
HOVERGENiHBG108607.
InParanoidiQ8NDW8.
OMAiMVQICLN.
OrthoDBiEOG091G00TY.
PhylomeDBiQ8NDW8.
TreeFamiTF314664.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168026-MONOMER.

Miscellaneous databases

ChiTaRSiTTC21A. human.
GenomeRNAii199223.
PROiQ8NDW8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168026.
CleanExiHS_TTC21A.
ExpressionAtlasiQ8NDW8. baseline and differential.
GenevisibleiQ8NDW8. HS.

Family and domain databases

Gene3Di1.25.40.10. 6 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 13 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 6 hits.
PROSITEiPS50005. TPR. 9 hits.
PS50293. TPR_REGION. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTT21A_HUMAN
AccessioniPrimary (citable) accession number: Q8NDW8
Secondary accession number(s): A1L388
, B4DYF6, B4DYJ3, D3YTE7, D4PHA5, Q6P5W8, Q8N7G5, Q8NA02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.