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Protein

Trinucleotide repeat-containing gene 6A protein

Gene

TNRC6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.6 Publications

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

RNA-mediated gene silencing, Translation regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1912408. Pre-NOTCH Transcription and Translation.
R-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-2559585. Oncogene Induced Senescence.
R-HSA-4086398. Ca2+ pathway.
R-HSA-426496. Post-transcriptional silencing by small RNAs.
R-HSA-5578749. Transcriptional regulation by small RNAs.
R-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-5687128. MAPK6/MAPK4 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Trinucleotide repeat-containing gene 6A protein
Alternative name(s):
CAG repeat protein 26
EMSY interactor protein
GW182 autoantigen
Short name:
Protein GW1
Glycine-tryptophan protein of 182 kDa
Gene namesi
Name:TNRC6A
Synonyms:CAGH26, KIAA1460, TNRC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:11969. TNRC6A.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic mRNA processing body Source: MGI
  • cytosol Source: Reactome
  • Golgi apparatus Source: HPA
  • intracellular membrane-bounded organelle Source: HPA
  • micro-ribonucleoprotein complex Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi313 – 3131W → A: Does not impair interaction with AGO2; when associated with A-345; A-370; A-420 and A-483. 1 Publication
Mutagenesisi345 – 3451W → A: Does not impair interaction with AGO2; when associated with A-313; A-370; A-420 and A-483. 1 Publication
Mutagenesisi370 – 3701W → A: Does not impair interaction with AGO2; when associated with A-313; A-345; A-420 and A-483. 1 Publication
Mutagenesisi420 – 4201W → A: Does not impair interaction with AGO2; when associated with A-313; A-345; A-370 and A-483. 1 Publication
Mutagenesisi483 – 4831W → A: Does not impair interaction with AGO2; when associated with A-313; A-345; A-370 and A-420. 1 Publication

Organism-specific databases

PharmGKBiPA36656.

Polymorphism and mutation databases

BioMutaiTNRC6A.
DMDMi296452846.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19621962Trinucleotide repeat-containing gene 6A proteinPRO_0000081980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei739 – 7391PhosphoserineCombined sources
Modified residuei878 – 8781PhosphoserineCombined sources
Modified residuei991 – 9911PhosphoserineCombined sources
Modified residuei1212 – 12121PhosphoserineCombined sources
Modified residuei1270 – 12701PhosphoserineCombined sources
Modified residuei1470 – 14701PhosphothreonineCombined sources
Modified residuei1585 – 15851PhosphoserineCombined sources
Modified residuei1869 – 18691PhosphoserineCombined sources
Modified residuei1890 – 18901PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NDV7.
MaxQBiQ8NDV7.
PaxDbiQ8NDV7.
PeptideAtlasiQ8NDV7.
PRIDEiQ8NDV7.

PTM databases

iPTMnetiQ8NDV7.
PhosphoSiteiQ8NDV7.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Inductioni

By exogenous short interfering RNA (siRNA).1 Publication

Gene expression databases

BgeeiENSG00000090905.
ExpressionAtlasiQ8NDV7. baseline and differential.
GenevisibleiQ8NDV7. HS.

Organism-specific databases

HPAiHPA015305.
HPA017869.

Interactioni

Subunit structurei

Interacts with AGO2 (PubMed:16284623, PubMed:16284622, PubMed:18690212, PubMed:19304925, PubMed:19324964, PubMed:19383768). Interacts with AGO1, AGO3 and AGO4 (PubMed:19324964, PubMed:19383768). Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT complex (PubMed:21981923). Interacts with ZC3H12A (PubMed:26134560).8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AGO1Q9UL184EBI-2269715,EBI-527363
AGO2Q9UKV810EBI-2269715,EBI-528269
AGO3Q9H9G73EBI-2269715,EBI-2267883
AGO4Q9HCK54EBI-2269715,EBI-2269696
CNOT1A5YKK62EBI-2269715,EBI-1222758
PAN3Q58A452EBI-2269715,EBI-2513054
TRIP13Q156453EBI-2269715,EBI-358993

Protein-protein interaction databases

BioGridi118141. 43 interactions.
DIPiDIP-54489N.
IntActiQ8NDV7. 61 interactions.
MINTiMINT-4535204.
STRINGi9606.ENSP00000379144.

Structurei

3D structure databases

ProteinModelPortaliQ8NDV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1781 – 185373RRMAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 932932Interaction with argonaute family proteinsAdd
BLAST
Regioni254 – 503250Sufficient for interaction with AGO1, AGO3 and AGO4Add
BLAST
Regioni270 – 34677Sufficient for interaction with AGO2Add
BLAST
Regioni318 – 39982Sufficient for interaction with AGO2Add
BLAST
Regioni340 – 439100Sufficient for interaction with AGO2Add
BLAST
Regioni409 – 49587Sufficient for interaction with AGO2Add
BLAST
Regioni502 – 751250Sufficient for interaction with AGO2Add
BLAST
Regioni566 – 1343778Sufficient for interaction with AGO1 and AGO4Add
BLAST
Regioni1074 – 114471Sufficient for interaction with AGO2Add
BLAST
Regioni1604 – 162219PABPC1-interacting motif-2 (PAM2)Add
BLAST
Regioni1670 – 1962293Sufficient for interaction with AGO2Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili7 – 5448Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi93 – 12735Gln-richAdd
BLAST
Compositional biasi192 – 365174Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the GW182 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF5S. Eukaryota.
ENOG41110AX. LUCA.
GeneTreeiENSGT00410000025966.
HOVERGENiHBG062594.
InParanoidiQ8NDV7.
KOiK18412.
OMAiRQNGNPS.
OrthoDBiEOG091G00G6.
PhylomeDBiQ8NDV7.
TreeFamiTF329702.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR019486. Argonaute_hook_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR032226. TNRC6_PABC-bd.
IPR033501. TNRC6A.
[Graphical view]
PANTHERiPTHR13020:SF28. PTHR13020:SF28. 2 hits.
PfamiPF10427. Ago_hook. 1 hit.
PF16608. TNRC6-PABC_bdg. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NDV7-1) [UniParc]FASTAAdd to basket
Also known as: TNGW1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRELEAKATK DVERNLSRDL VQEEEQLMEE KKKKKDDKKK KEAAQKKATE
60 70 80 90 100
QKIKVPEQIK PSVSQPQPAN SNNGTSTATS TNNNAKRATA NNQQPQQQQQ
110 120 130 140 150
QQQPQQQQPQ QQPQPQPQQQ QPQQQPQALP RYPREVPPRF RHQEHKQLLK
160 170 180 190 200
RGQHFPVIAA NLGSAVKVLN SQSESSALTN QQPQNNGEVQ NSKNQSDINH
210 220 230 240 250
STSGSHYENS QRGPVSSTSD SSTNCKNAVV SDLSEKEAWP SAPGSDPELA
260 270 280 290 300
SECMDADSAS SSESERNITI MASGNTGGEK DGLRNSTGLG SQNKFVVGSS
310 320 330 340 350
SNNVGHGSST GPWGFSHGAI ISTCQVSVDA PESKSESSNN RMNAWGTVSS
360 370 380 390 400
SSNGGLNPST LNSASNHGAW PVLENNGLAL KGPVGSGSSG INIQCSTIGQ
410 420 430 440 450
MPNNQSINSK VSGGSTHGTW GSLQETCESE VSGTQKVSFS GQPQNITTEM
460 470 480 490 500
TGPNNTTNFM TSSLPNSGSV QNNELPSSNT GAWRVSTMNH PQMQAPSGMN
510 520 530 540 550
GTSLSHLSNG ESKSGGSYGT TWGAYGSNYS GDKCSGPNGQ ANGDTVNATL
560 570 580 590 600
MQPGVNGPMG TNFQVNTNKG GGVWESGAAN SQSTSWGSGN GANSGGSRRG
610 620 630 640 650
WGTPAQNTGT NLPSVEWNKL PSNQHSNDSA NGNGKTFTNG WKSTEEEDQG
660 670 680 690 700
SATSQTNEQS SVWAKTGGTV ESDGSTESTG RLEEKGTGES QSRDRRKIDQ
710 720 730 740 750
HTLLQSIVNR TDLDPRVLSN SGWGQTPIKQ NTAWDTETSP RGERKTDNGT
760 770 780 790 800
EAWGSSATQT FNSGACIDKT SPNGNDTSSV SGWGDPKPAL RWGDSKGSNC
810 820 830 840 850
QGGWEDDSAA TGMVKSNQWG NCKEEKAAWN DSQKNKQGWG DGQKSSQGWS
860 870 880 890 900
VSASDNWGET SRNNHWGEAN KKSSSGGSDS DRSVSGWNEL GKTSSFTWGN
910 920 930 940 950
NINPNNSSGW DESSKPTPSQ GWGDPPKSNQ SLGWGDSSKP VSSPDWNKQQ
960 970 980 990 1000
DIVGSWGIPP ATGKPPGTGW LGGPIPAPAK EEEPTGWEEP SPESIRRKME
1010 1020 1030 1040 1050
IDDGTSAWGD PSKYNYKNVN MWNKNVPNGN SRSDQQAQVH QLLTPASAIS
1060 1070 1080 1090 1100
NKEASSGSGW GEPWGEPSTP ATTVDNGTSA WGKPIDSGPS WGEPIAAASS
1110 1120 1130 1140 1150
TSTWGSSSVG PQALSKSGPK SMQDGWCGDD MPLPGNRPTG WEEEEDVEIG
1160 1170 1180 1190 1200
MWNSNSSQEL NSSLNWPPYT KKMSSKGLSG KKRRRERGMM KGGNKQEEAW
1210 1220 1230 1240 1250
INPFVKQFSN ISFSRDSPEE NVQSNKMDLS GGMLQDKRME IDKHSLNIGD
1260 1270 1280 1290 1300
YNRTVGKGPG SRPQISKESS MERNPYFDKD GIVADESQNM QFMSSQSMKL
1310 1320 1330 1340 1350
PPSNSALPNQ ALGSIAGLGM QNLNSVRQNG NPSMFGVGNT AAQPRGMQQP
1360 1370 1380 1390 1400
PAQPLSSSQP NLRAQVPPPL LSPQVPVSLL KYAPNNGGLN PLFGPQQVAM
1410 1420 1430 1440 1450
LNQLSQLNQL SQISQLQRLL AQQQRAQSQR SVPSGNRPQQ DQQGRPLSVQ
1460 1470 1480 1490 1500
QQMMQQSRQL DPNLLVKQQT PPSQQQPLHQ PAMKSFLDNV MPHTTPELQK
1510 1520 1530 1540 1550
GPSPINAFSN FPIGLNSNLN VNMDMNSIKE PQSRLRKWTT VDSISVNTSL
1560 1570 1580 1590 1600
DQNSSKHGAI SSGFRLEESP FVPYDFMNSS TSPASPPGSI GDGWPRAKSP
1610 1620 1630 1640 1650
NGSSSVNWPP EFRPGEPWKG YPNIDPETDP YVTPGSVINN LSINTVREVD
1660 1670 1680 1690 1700
HLRDRNSGSS SSLNTTLPST SAWSSIRASN YNVPLSSTAQ STSARNSDSK
1710 1720 1730 1740 1750
LTWSPGSVTN TSLAHELWKV PLPPKNITAP SRPPPGLTGQ KPPLSTWDNS
1760 1770 1780 1790 1800
PLRIGGGWGN SDARYTPGSS WGESSSGRIT NWLVLKNLTP QIDGSTLRTL
1810 1820 1830 1840 1850
CMQHGPLITF HLNLPHGNAL VRYSSKEEVV KAQKSLHMCV LGNTTILAEF
1860 1870 1880 1890 1900
ASEEEISRFF AQSQSLTPSP GWQSLGSSQS RLGSLDCSHS FSSRTDLNHW
1910 1920 1930 1940 1950
NGAGLSGTNC GDLHGTSLWG TPHYSTSLWG PPSSSDPRGI SSPSPINAFL
1960
SVDHLGGGGE SM
Length:1,962
Mass (Da):210,297
Last modified:May 18, 2010 - v2
Checksum:i963C054628E18592
GO
Isoform 2 (identifier: Q8NDV7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-253: Missing.

Show »
Length:1,709
Mass (Da):182,053
Checksum:i6CCAC36D8FE45088
GO
Isoform 3 (identifier: Q8NDV7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1232: Missing.
     1280-1328: Missing.
     1611-1962: Missing.

Show »
Length:329
Mass (Da):36,154
Checksum:i4A18C3669378FF04
GO
Isoform 4 (identifier: Q8NDV7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1801: Missing.

Show »
Length:161
Mass (Da):17,151
Checksum:i2725AD138B814BCE
GO
Isoform 5 (identifier: Q8NDV7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: MRELEAKATK...QKKATEQKIK → MAYFGGTLYWLIFSTPFLLLGL

Note: No experimental confirmation available.
Show »
Length:1,930
Mass (Da):206,363
Checksum:i24936EA0AD526EB1
GO
Isoform 6 (identifier: Q8NDV7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1280-1328: Missing.

Show »
Length:1,913
Mass (Da):205,151
Checksum:i3F1228974880B3E2
GO

Sequence cautioni

The sequence BAA91899 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD28525 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 344KKKK → TEKE in CAD37348 (Ref. 2) Curated
Sequence conflicti1375 – 13751V → VV in CAD28525 (PubMed:17974005).Curated
Sequence conflicti1704 – 17041S → F in BAA91899 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti185 – 1851N → K.
Corresponds to variant rs11639856 [ dbSNP | Ensembl ].
VAR_057251
Natural varianti592 – 5921A → T.
Corresponds to variant rs6497759 [ dbSNP | Ensembl ].
VAR_057252
Natural varianti788 – 7881P → S.
Corresponds to variant rs3803716 [ dbSNP | Ensembl ].
VAR_057253
Natural varianti1268 – 12681E → K.
Corresponds to variant rs2112782 [ dbSNP | Ensembl ].
VAR_057254

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 18011801Missing in isoform 4. 1 PublicationVSP_013292Add
BLAST
Alternative sequencei1 – 12321232Missing in isoform 3. 1 PublicationVSP_037287Add
BLAST
Alternative sequencei1 – 253253Missing in isoform 2. 1 PublicationVSP_013294Add
BLAST
Alternative sequencei1 – 5454MRELE…EQKIK → MAYFGGTLYWLIFSTPFLLL GL in isoform 5. 1 PublicationVSP_013295Add
BLAST
Alternative sequencei1280 – 132849Missing in isoform 3 and isoform 6. 1 PublicationVSP_037288Add
BLAST
Alternative sequencei1611 – 1962352Missing in isoform 3. 1 PublicationVSP_037289Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY035864 mRNA. Translation: AAK62026.1.
AJ492221 mRNA. Translation: CAD37348.1.
AL713750 mRNA. Translation: CAD28525.2. Different initiation.
AL833757 mRNA. Translation: CAH56236.1.
AC002565 Genomic DNA. No translation available.
AC008731 Genomic DNA. No translation available.
BC024324 mRNA. Translation: AAH24324.2.
BC068209 mRNA. No translation available.
U80739 mRNA. Translation: AAB91438.1.
AB040893 mRNA. Translation: BAA95984.1.
AK001773 mRNA. Translation: BAA91899.1. Different initiation.
CCDSiCCDS10624.2. [Q8NDV7-1]
RefSeqiNP_055309.2. NM_014494.2. [Q8NDV7-1]
XP_005255311.1. XM_005255254.3. [Q8NDV7-6]
XP_005255314.1. XM_005255257.4. [Q8NDV7-2]
UniGeneiHs.655057.

Genome annotation databases

EnsembliENST00000315183; ENSP00000326900; ENSG00000090905. [Q8NDV7-6]
ENST00000395799; ENSP00000379144; ENSG00000090905. [Q8NDV7-1]
GeneIDi27327.
KEGGihsa:27327.
UCSCiuc002dmm.4. human. [Q8NDV7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY035864 mRNA. Translation: AAK62026.1.
AJ492221 mRNA. Translation: CAD37348.1.
AL713750 mRNA. Translation: CAD28525.2. Different initiation.
AL833757 mRNA. Translation: CAH56236.1.
AC002565 Genomic DNA. No translation available.
AC008731 Genomic DNA. No translation available.
BC024324 mRNA. Translation: AAH24324.2.
BC068209 mRNA. No translation available.
U80739 mRNA. Translation: AAB91438.1.
AB040893 mRNA. Translation: BAA95984.1.
AK001773 mRNA. Translation: BAA91899.1. Different initiation.
CCDSiCCDS10624.2. [Q8NDV7-1]
RefSeqiNP_055309.2. NM_014494.2. [Q8NDV7-1]
XP_005255311.1. XM_005255254.3. [Q8NDV7-6]
XP_005255314.1. XM_005255257.4. [Q8NDV7-2]
UniGeneiHs.655057.

3D structure databases

ProteinModelPortaliQ8NDV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118141. 43 interactions.
DIPiDIP-54489N.
IntActiQ8NDV7. 61 interactions.
MINTiMINT-4535204.
STRINGi9606.ENSP00000379144.

PTM databases

iPTMnetiQ8NDV7.
PhosphoSiteiQ8NDV7.

Polymorphism and mutation databases

BioMutaiTNRC6A.
DMDMi296452846.

Proteomic databases

EPDiQ8NDV7.
MaxQBiQ8NDV7.
PaxDbiQ8NDV7.
PeptideAtlasiQ8NDV7.
PRIDEiQ8NDV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315183; ENSP00000326900; ENSG00000090905. [Q8NDV7-6]
ENST00000395799; ENSP00000379144; ENSG00000090905. [Q8NDV7-1]
GeneIDi27327.
KEGGihsa:27327.
UCSCiuc002dmm.4. human. [Q8NDV7-1]

Organism-specific databases

CTDi27327.
GeneCardsiTNRC6A.
H-InvDBHIX0012904.
HIX0173209.
HGNCiHGNC:11969. TNRC6A.
HPAiHPA015305.
HPA017869.
MIMi610739. gene.
neXtProtiNX_Q8NDV7.
PharmGKBiPA36656.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF5S. Eukaryota.
ENOG41110AX. LUCA.
GeneTreeiENSGT00410000025966.
HOVERGENiHBG062594.
InParanoidiQ8NDV7.
KOiK18412.
OMAiRQNGNPS.
OrthoDBiEOG091G00G6.
PhylomeDBiQ8NDV7.
TreeFamiTF329702.

Enzyme and pathway databases

ReactomeiR-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1912408. Pre-NOTCH Transcription and Translation.
R-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-2559585. Oncogene Induced Senescence.
R-HSA-4086398. Ca2+ pathway.
R-HSA-426496. Post-transcriptional silencing by small RNAs.
R-HSA-5578749. Transcriptional regulation by small RNAs.
R-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-5687128. MAPK6/MAPK4 signaling.

Miscellaneous databases

ChiTaRSiTNRC6A. human.
GeneWikiiTNRC6A.
GenomeRNAii27327.
PROiQ8NDV7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000090905.
ExpressionAtlasiQ8NDV7. baseline and differential.
GenevisibleiQ8NDV7. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR019486. Argonaute_hook_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR032226. TNRC6_PABC-bd.
IPR033501. TNRC6A.
[Graphical view]
PANTHERiPTHR13020:SF28. PTHR13020:SF28. 2 hits.
PfamiPF10427. Ago_hook. 1 hit.
PF16608. TNRC6-PABC_bdg. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTNR6A_HUMAN
AccessioniPrimary (citable) accession number: Q8NDV7
Secondary accession number(s): C9JAR8
, O15408, Q658L5, Q6NVB5, Q8NEZ0, Q8TBT8, Q8TCR0, Q9NV59, Q9P268
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against TNRC6A are found in sera from patients with Sjoegren syndrome (SS), ataxia and sensor neuropathy diseases that developed autoantibodies against protein of the GWB structure. Autoantibodies were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.