Q8NDV7 (TNR6A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trinucleotide repeat-containing gene 6A protein

Alternative name(s):
CAG repeat protein 26
EMSY interactor protein
GW182 autoantigen
Short name=Protein GW1
Glycine-tryptophan protein of 182 kDa

Gene names

Name:	TNRC6A
Synonyms:	CAGH26, KIAA1460, TNRC6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1962 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. Ref.13 Ref.14 Ref.17 Ref.19 Ref.21 Ref.25
Subunit structure	Interacts with EIF2C1/AGO1, EIF2C2/AGO2, EIF2C3/AGO3 and EIF2C4/AGO4. Ref.13 Ref.14 Ref.22 Ref.25 Ref.26
Subcellular location	Cytoplasm › P-body. Note: Mammalian P-bodies are also known as GW bodies (GWBs). Ref.1 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.16 Ref.21 Ref.24 Ref.26
Tissue specificity	Ubiquitous. Ref.1
Induction	By exogenous short interfering RNA (siRNA). Ref.24
Miscellaneous	Antibodies against TNRC6A are found in sera from patients with Sjoegren syndrome (SS), ataxia and sensor neuropathy diseases that developed autoantibodies against protein of the GWB structure. Autoantibodies were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein.
Sequence similarities	Belongs to the GW182 family. Contains 1 RRM (RNA recognition motif) domain.
Sequence caution	The sequence BAA91899.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAD28525.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	RNA-mediated gene silencing Translation regulation
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	RNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	negative regulation of translation involved in gene silencing by miRNA Inferred from direct assay Ref.17. Source: UniProtKB
Cellular component	cytoplasmic mRNA processing body Inferred from direct assay. Source: MGI micro-ribonucleoprotein complex Inferred from direct assay Ref.17. Source: UniProtKB
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NDV7-1)

Also known as: TNGW1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NDV7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-253: Missing.

Isoform 3 (identifier: Q8NDV7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1232: Missing.
     1280-1328: Missing.
     1611-1962: Missing.

Isoform 4 (identifier: Q8NDV7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1801: Missing.

Isoform 5 (identifier: Q8NDV7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: MRELEAKATK...QKKATEQKIK → MAYFGGTLYWLIFSTPFLLLGL

Note: No experimental confirmation available.

Isoform 6 (identifier: Q8NDV7-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1280-1328: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1962	1962	Trinucleotide repeat-containing gene 6A protein		PRO_0000081980
Regions
	Domain	1781 – 1853	73	RRM
	Region	254 – 503	250	Sufficient for interaction with EIF2C1, EIF2C3 and EIF2C4
	Region	270 – 346	77	Sufficient for interaction with EIF2C2
	Region	318 – 399	82	Sufficient for interaction with EIF2C2
	Region	340 – 439	100	Sufficient for interaction with EIF2C2
	Region	409 – 495	87	Sufficient for interaction with EIF2C2
	Region	502 – 751	250	Sufficient for interaction with EIF2C2
	Region	566 – 1343	778	Sufficient for interaction with EIF2C1 and EIF2C4
	Region	1074 – 1144	71	Sufficient for interaction with EIF2C2
	Region	1670 – 1962	293	Sufficient for interaction with EIF2C2
	Coiled coil	7 – 54	48	Potential
	Compositional bias	93 – 127	35	Gln-rich
	Compositional bias	192 – 365	174	Ser-rich
Amino acid modifications
	Modified residue	991	1	Phosphoserine By similarity
	Modified residue	1470	1	Phosphothreonine Ref.23
	Modified residue	1585	1	Phosphoserine Ref.27
Natural variations
	Alternative sequence	1 – 1801	1801	Missing in isoform 4.		VSP_013292
	Alternative sequence	1 – 1232	1232	Missing in isoform 3.		VSP_037287
	Alternative sequence	1 – 253	253	Missing in isoform 2.		VSP_013294
	Alternative sequence	1 – 54	54	MRELE…EQKIK → MAYFGGTLYWLIFSTPFLLL GL in isoform 5.		VSP_013295
	Alternative sequence	1280 – 1328	49	Missing in isoform 3 and isoform 6.		VSP_037288
	Alternative sequence	1611 – 1962	352	Missing in isoform 3.		VSP_037289
	Natural variant	185	1	N → K. Corresponds to variant rs11639856 [ dbSNP | Ensembl ].		VAR_057251
	Natural variant	592	1	A → T. Corresponds to variant rs6497759 [ dbSNP | Ensembl ].		VAR_057252
	Natural variant	788	1	P → S. Corresponds to variant rs3803716 [ dbSNP | Ensembl ].		VAR_057253
	Natural variant	1268	1	E → K. Corresponds to variant rs2112782 [ dbSNP | Ensembl ].		VAR_057254
Experimental info
	Mutagenesis	313	1	W → A: Does not impair interaction with EIF2C2; when associated with A-345; A-370; A-420 and A-483. Ref.26
	Mutagenesis	345	1	W → A: Does not impair interaction with EIF2C2; when associated with A-313; A-370; A-420 and A-483. Ref.26
	Mutagenesis	370	1	W → A: Does not impair interaction with EIF2C2; when associated with A-313; A-345; A-420 and A-483. Ref.26
	Mutagenesis	420	1	W → A: Does not impair interaction with EIF2C2; when associated with A-313; A-345; A-370 and A-483. Ref.26
	Mutagenesis	483	1	W → A: Does not impair interaction with EIF2C2; when associated with A-313; A-345; A-370 and A-420. Ref.26
	Sequence conflict	31 – 34	4	KKKK → TEKE in CAD37348. Ref.2
	Sequence conflict	1375	1	V → VV in CAD28525. Ref.3
	Sequence conflict	1704	1	S → F in BAA91899. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (TNGW1) [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 963C054628E18592	FASTA	1,962	210,297
	10 20 30 40 50 60 MRELEAKATK DVERNLSRDL VQEEEQLMEE KKKKKDDKKK KEAAQKKATE QKIKVPEQIK 70 80 90 100 110 120 PSVSQPQPAN SNNGTSTATS TNNNAKRATA NNQQPQQQQQ QQQPQQQQPQ QQPQPQPQQQ 130 140 150 160 170 180 QPQQQPQALP RYPREVPPRF RHQEHKQLLK RGQHFPVIAA NLGSAVKVLN SQSESSALTN 190 200 210 220 230 240 QQPQNNGEVQ NSKNQSDINH STSGSHYENS QRGPVSSTSD SSTNCKNAVV SDLSEKEAWP 250 260 270 280 290 300 SAPGSDPELA SECMDADSAS SSESERNITI MASGNTGGEK DGLRNSTGLG SQNKFVVGSS 310 320 330 340 350 360 SNNVGHGSST GPWGFSHGAI ISTCQVSVDA PESKSESSNN RMNAWGTVSS SSNGGLNPST 370 380 390 400 410 420 LNSASNHGAW PVLENNGLAL KGPVGSGSSG INIQCSTIGQ MPNNQSINSK VSGGSTHGTW 430 440 450 460 470 480 GSLQETCESE VSGTQKVSFS GQPQNITTEM TGPNNTTNFM TSSLPNSGSV QNNELPSSNT 490 500 510 520 530 540 GAWRVSTMNH PQMQAPSGMN GTSLSHLSNG ESKSGGSYGT TWGAYGSNYS GDKCSGPNGQ 550 560 570 580 590 600 ANGDTVNATL MQPGVNGPMG TNFQVNTNKG GGVWESGAAN SQSTSWGSGN GANSGGSRRG 610 620 630 640 650 660 WGTPAQNTGT NLPSVEWNKL PSNQHSNDSA NGNGKTFTNG WKSTEEEDQG SATSQTNEQS 670 680 690 700 710 720 SVWAKTGGTV ESDGSTESTG RLEEKGTGES QSRDRRKIDQ HTLLQSIVNR TDLDPRVLSN 730 740 750 760 770 780 SGWGQTPIKQ NTAWDTETSP RGERKTDNGT EAWGSSATQT FNSGACIDKT SPNGNDTSSV 790 800 810 820 830 840 SGWGDPKPAL RWGDSKGSNC QGGWEDDSAA TGMVKSNQWG NCKEEKAAWN DSQKNKQGWG 850 860 870 880 890 900 DGQKSSQGWS VSASDNWGET SRNNHWGEAN KKSSSGGSDS DRSVSGWNEL GKTSSFTWGN 910 920 930 940 950 960 NINPNNSSGW DESSKPTPSQ GWGDPPKSNQ SLGWGDSSKP VSSPDWNKQQ DIVGSWGIPP 970 980 990 1000 1010 1020 ATGKPPGTGW LGGPIPAPAK EEEPTGWEEP SPESIRRKME IDDGTSAWGD PSKYNYKNVN 1030 1040 1050 1060 1070 1080 MWNKNVPNGN SRSDQQAQVH QLLTPASAIS NKEASSGSGW GEPWGEPSTP ATTVDNGTSA 1090 1100 1110 1120 1130 1140 WGKPIDSGPS WGEPIAAASS TSTWGSSSVG PQALSKSGPK SMQDGWCGDD MPLPGNRPTG 1150 1160 1170 1180 1190 1200 WEEEEDVEIG MWNSNSSQEL NSSLNWPPYT KKMSSKGLSG KKRRRERGMM KGGNKQEEAW 1210 1220 1230 1240 1250 1260 INPFVKQFSN ISFSRDSPEE NVQSNKMDLS GGMLQDKRME IDKHSLNIGD YNRTVGKGPG 1270 1280 1290 1300 1310 1320 SRPQISKESS MERNPYFDKD GIVADESQNM QFMSSQSMKL PPSNSALPNQ ALGSIAGLGM 1330 1340 1350 1360 1370 1380 QNLNSVRQNG NPSMFGVGNT AAQPRGMQQP PAQPLSSSQP NLRAQVPPPL LSPQVPVSLL 1390 1400 1410 1420 1430 1440 KYAPNNGGLN PLFGPQQVAM LNQLSQLNQL SQISQLQRLL AQQQRAQSQR SVPSGNRPQQ 1450 1460 1470 1480 1490 1500 DQQGRPLSVQ QQMMQQSRQL DPNLLVKQQT PPSQQQPLHQ PAMKSFLDNV MPHTTPELQK 1510 1520 1530 1540 1550 1560 GPSPINAFSN FPIGLNSNLN VNMDMNSIKE PQSRLRKWTT VDSISVNTSL DQNSSKHGAI 1570 1580 1590 1600 1610 1620 SSGFRLEESP FVPYDFMNSS TSPASPPGSI GDGWPRAKSP NGSSSVNWPP EFRPGEPWKG 1630 1640 1650 1660 1670 1680 YPNIDPETDP YVTPGSVINN LSINTVREVD HLRDRNSGSS SSLNTTLPST SAWSSIRASN 1690 1700 1710 1720 1730 1740 YNVPLSSTAQ STSARNSDSK LTWSPGSVTN TSLAHELWKV PLPPKNITAP SRPPPGLTGQ 1750 1760 1770 1780 1790 1800 KPPLSTWDNS PLRIGGGWGN SDARYTPGSS WGESSSGRIT NWLVLKNLTP QIDGSTLRTL 1810 1820 1830 1840 1850 1860 CMQHGPLITF HLNLPHGNAL VRYSSKEEVV KAQKSLHMCV LGNTTILAEF ASEEEISRFF 1870 1880 1890 1900 1910 1920 AQSQSLTPSP GWQSLGSSQS RLGSLDCSHS FSSRTDLNHW NGAGLSGTNC GDLHGTSLWG 1930 1940 1950 1960 TPHYSTSLWG PPSSSDPRGI SSPSPINAFL SVDHLGGGGE SM
	Isoform 2 [UniParc]. Checksum: 6CCAC36D8FE45088	FASTA	1,709	182,053
	10 20 30 40 50 60 MDADSASSSE SERNITIMAS GNTGGEKDGL RNSTGLGSQN KFVVGSSSNN VGHGSSTGPW 70 80 90 100 110 120 GFSHGAIIST CQVSVDAPES KSESSNNRMN AWGTVSSSSN GGLNPSTLNS ASNHGAWPVL 130 140 150 160 170 180 ENNGLALKGP VGSGSSGINI QCSTIGQMPN NQSINSKVSG GSTHGTWGSL QETCESEVSG 190 200 210 220 230 240 TQKVSFSGQP QNITTEMTGP NNTTNFMTSS LPNSGSVQNN ELPSSNTGAW RVSTMNHPQM 250 260 270 280 290 300 QAPSGMNGTS LSHLSNGESK SGGSYGTTWG AYGSNYSGDK CSGPNGQANG DTVNATLMQP 310 320 330 340 350 360 GVNGPMGTNF QVNTNKGGGV WESGAANSQS TSWGSGNGAN SGGSRRGWGT PAQNTGTNLP 370 380 390 400 410 420 SVEWNKLPSN QHSNDSANGN GKTFTNGWKS TEEEDQGSAT SQTNEQSSVW AKTGGTVESD 430 440 450 460 470 480 GSTESTGRLE EKGTGESQSR DRRKIDQHTL LQSIVNRTDL DPRVLSNSGW GQTPIKQNTA 490 500 510 520 530 540 WDTETSPRGE RKTDNGTEAW GSSATQTFNS GACIDKTSPN GNDTSSVSGW GDPKPALRWG 550 560 570 580 590 600 DSKGSNCQGG WEDDSAATGM VKSNQWGNCK EEKAAWNDSQ KNKQGWGDGQ KSSQGWSVSA 610 620 630 640 650 660 SDNWGETSRN NHWGEANKKS SSGGSDSDRS VSGWNELGKT SSFTWGNNIN PNNSSGWDES 670 680 690 700 710 720 SKPTPSQGWG DPPKSNQSLG WGDSSKPVSS PDWNKQQDIV GSWGIPPATG KPPGTGWLGG 730 740 750 760 770 780 PIPAPAKEEE PTGWEEPSPE SIRRKMEIDD GTSAWGDPSK YNYKNVNMWN KNVPNGNSRS 790 800 810 820 830 840 DQQAQVHQLL TPASAISNKE ASSGSGWGEP WGEPSTPATT VDNGTSAWGK PIDSGPSWGE 850 860 870 880 890 900 PIAAASSTST WGSSSVGPQA LSKSGPKSMQ DGWCGDDMPL PGNRPTGWEE EEDVEIGMWN 910 920 930 940 950 960 SNSSQELNSS LNWPPYTKKM SSKGLSGKKR RRERGMMKGG NKQEEAWINP FVKQFSNISF 970 980 990 1000 1010 1020 SRDSPEENVQ SNKMDLSGGM LQDKRMEIDK HSLNIGDYNR TVGKGPGSRP QISKESSMER 1030 1040 1050 1060 1070 1080 NPYFDKDGIV ADESQNMQFM SSQSMKLPPS NSALPNQALG SIAGLGMQNL NSVRQNGNPS 1090 1100 1110 1120 1130 1140 MFGVGNTAAQ PRGMQQPPAQ PLSSSQPNLR AQVPPPLLSP QVPVSLLKYA PNNGGLNPLF 1150 1160 1170 1180 1190 1200 GPQQVAMLNQ LSQLNQLSQI SQLQRLLAQQ QRAQSQRSVP SGNRPQQDQQ GRPLSVQQQM 1210 1220 1230 1240 1250 1260 MQQSRQLDPN LLVKQQTPPS QQQPLHQPAM KSFLDNVMPH TTPELQKGPS PINAFSNFPI 1270 1280 1290 1300 1310 1320 GLNSNLNVNM DMNSIKEPQS RLRKWTTVDS ISVNTSLDQN SSKHGAISSG FRLEESPFVP 1330 1340 1350 1360 1370 1380 YDFMNSSTSP ASPPGSIGDG WPRAKSPNGS SSVNWPPEFR PGEPWKGYPN IDPETDPYVT 1390 1400 1410 1420 1430 1440 PGSVINNLSI NTVREVDHLR DRNSGSSSSL NTTLPSTSAW SSIRASNYNV PLSSTAQSTS 1450 1460 1470 1480 1490 1500 ARNSDSKLTW SPGSVTNTSL AHELWKVPLP PKNITAPSRP PPGLTGQKPP LSTWDNSPLR 1510 1520 1530 1540 1550 1560 IGGGWGNSDA RYTPGSSWGE SSSGRITNWL VLKNLTPQID GSTLRTLCMQ HGPLITFHLN 1570 1580 1590 1600 1610 1620 LPHGNALVRY SSKEEVVKAQ KSLHMCVLGN TTILAEFASE EEISRFFAQS QSLTPSPGWQ 1630 1640 1650 1660 1670 1680 SLGSSQSRLG SLDCSHSFSS RTDLNHWNGA GLSGTNCGDL HGTSLWGTPH YSTSLWGPPS 1690 1700 SSDPRGISSP SPINAFLSVD HLGGGGESM
	Isoform 3 [UniParc]. Checksum: 4A18C3669378FF04	FASTA	329	36,154
	10 20 30 40 50 60 MLQDKRMEID KHSLNIGDYN RTVGKGPGSR PQISKESSME RNPYFDKNGN PSMFGVGNTA 70 80 90 100 110 120 AQPRGMQQPP AQPLSSSQPN LRAQVPPPLL SPQVPVSLLK YAPNNGGLNP LFGPQQVAML 130 140 150 160 170 180 NQLSQLNQLS QISQLQRLLA QQQRAQSQRS VPSGNRPQQD QQGRPLSVQQ QMMQQSRQLD 190 200 210 220 230 240 PNLLVKQQTP PSQQQPLHQP AMKSFLDNVM PHTTPELQKG PSPINAFSNF PIGLNSNLNV 250 260 270 280 290 300 NMDMNSIKEP QSRLRKWTTV DSISVNTSLD QNSSKHGAIS SGFRLEESPF VPYDFMNSST 310 320 SPASPPGSIG DGWPRAKSPN GSSSVNWPP
	Isoform 4 [UniParc]. Checksum: 2725AD138B814BCE	FASTA	161	17,151
	10 20 30 40 50 60 MQHGPLITFH LNLPHGNALV RYSSKEEVVK AQKSLHMCVL GNTTILAEFA SEEEISRFFA 70 80 90 100 110 120 QSQSLTPSPG WQSLGSSQSR LGSLDCSHSF SSRTDLNHWN GAGLSGTNCG DLHGTSLWGT 130 140 150 160 PHYSTSLWGP PSSSDPRGIS SPSPINAFLS VDHLGGGGES M
	Isoform 5 [UniParc]. Checksum: 24936EA0AD526EB1	FASTA	1,930	206,363
	10 20 30 40 50 60 MAYFGGTLYW LIFSTPFLLL GLVPEQIKPS VSQPQPANSN NGTSTATSTN NNAKRATANN 70 80 90 100 110 120 QQPQQQQQQQ QPQQQQPQQQ PQPQPQQQQP QQQPQALPRY PREVPPRFRH QEHKQLLKRG 130 140 150 160 170 180 QHFPVIAANL GSAVKVLNSQ SESSALTNQQ PQNNGEVQNS KNQSDINHST SGSHYENSQR 190 200 210 220 230 240 GPVSSTSDSS TNCKNAVVSD LSEKEAWPSA PGSDPELASE CMDADSASSS ESERNITIMA 250 260 270 280 290 300 SGNTGGEKDG LRNSTGLGSQ NKFVVGSSSN NVGHGSSTGP WGFSHGAIIS TCQVSVDAPE 310 320 330 340 350 360 SKSESSNNRM NAWGTVSSSS NGGLNPSTLN SASNHGAWPV LENNGLALKG PVGSGSSGIN 370 380 390 400 410 420 IQCSTIGQMP NNQSINSKVS GGSTHGTWGS LQETCESEVS GTQKVSFSGQ PQNITTEMTG 430 440 450 460 470 480 PNNTTNFMTS SLPNSGSVQN NELPSSNTGA WRVSTMNHPQ MQAPSGMNGT SLSHLSNGES 490 500 510 520 530 540 KSGGSYGTTW GAYGSNYSGD KCSGPNGQAN GDTVNATLMQ PGVNGPMGTN FQVNTNKGGG 550 560 570 580 590 600 VWESGAANSQ STSWGSGNGA NSGGSRRGWG TPAQNTGTNL PSVEWNKLPS NQHSNDSANG 610 620 630 640 650 660 NGKTFTNGWK STEEEDQGSA TSQTNEQSSV WAKTGGTVES DGSTESTGRL EEKGTGESQS 670 680 690 700 710 720 RDRRKIDQHT LLQSIVNRTD LDPRVLSNSG WGQTPIKQNT AWDTETSPRG ERKTDNGTEA 730 740 750 760 770 780 WGSSATQTFN SGACIDKTSP NGNDTSSVSG WGDPKPALRW GDSKGSNCQG GWEDDSAATG 790 800 810 820 830 840 MVKSNQWGNC KEEKAAWNDS QKNKQGWGDG QKSSQGWSVS ASDNWGETSR NNHWGEANKK 850 860 870 880 890 900 SSSGGSDSDR SVSGWNELGK TSSFTWGNNI NPNNSSGWDE SSKPTPSQGW GDPPKSNQSL 910 920 930 940 950 960 GWGDSSKPVS SPDWNKQQDI VGSWGIPPAT GKPPGTGWLG GPIPAPAKEE EPTGWEEPSP 970 980 990 1000 1010 1020 ESIRRKMEID DGTSAWGDPS KYNYKNVNMW NKNVPNGNSR SDQQAQVHQL LTPASAISNK 1030 1040 1050 1060 1070 1080 EASSGSGWGE PWGEPSTPAT TVDNGTSAWG KPIDSGPSWG EPIAAASSTS TWGSSSVGPQ 1090 1100 1110 1120 1130 1140 ALSKSGPKSM QDGWCGDDMP LPGNRPTGWE EEEDVEIGMW NSNSSQELNS SLNWPPYTKK 1150 1160 1170 1180 1190 1200 MSSKGLSGKK RRRERGMMKG GNKQEEAWIN PFVKQFSNIS FSRDSPEENV QSNKMDLSGG 1210 1220 1230 1240 1250 1260 MLQDKRMEID KHSLNIGDYN RTVGKGPGSR PQISKESSME RNPYFDKDGI VADESQNMQF 1270 1280 1290 1300 1310 1320 MSSQSMKLPP SNSALPNQAL GSIAGLGMQN LNSVRQNGNP SMFGVGNTAA QPRGMQQPPA 1330 1340 1350 1360 1370 1380 QPLSSSQPNL RAQVPPPLLS PQVPVSLLKY APNNGGLNPL FGPQQVAMLN QLSQLNQLSQ 1390 1400 1410 1420 1430 1440 ISQLQRLLAQ QQRAQSQRSV PSGNRPQQDQ QGRPLSVQQQ MMQQSRQLDP NLLVKQQTPP 1450 1460 1470 1480 1490 1500 SQQQPLHQPA MKSFLDNVMP HTTPELQKGP SPINAFSNFP IGLNSNLNVN MDMNSIKEPQ 1510 1520 1530 1540 1550 1560 SRLRKWTTVD SISVNTSLDQ NSSKHGAISS GFRLEESPFV PYDFMNSSTS PASPPGSIGD 1570 1580 1590 1600 1610 1620 GWPRAKSPNG SSSVNWPPEF RPGEPWKGYP NIDPETDPYV TPGSVINNLS INTVREVDHL 1630 1640 1650 1660 1670 1680 RDRNSGSSSS LNTTLPSTSA WSSIRASNYN VPLSSTAQST SARNSDSKLT WSPGSVTNTS 1690 1700 1710 1720 1730 1740 LAHELWKVPL PPKNITAPSR PPPGLTGQKP PLSTWDNSPL RIGGGWGNSD ARYTPGSSWG 1750 1760 1770 1780 1790 1800 ESSSGRITNW LVLKNLTPQI DGSTLRTLCM QHGPLITFHL NLPHGNALVR YSSKEEVVKA 1810 1820 1830 1840 1850 1860 QKSLHMCVLG NTTILAEFAS EEEISRFFAQ SQSLTPSPGW QSLGSSQSRL GSLDCSHSFS 1870 1880 1890 1900 1910 1920 SRTDLNHWNG AGLSGTNCGD LHGTSLWGTP HYSTSLWGPP SSSDPRGISS PSPINAFLSV 1930 DHLGGGGESM
	Isoform 6 [UniParc]. Checksum: 3F1228974880B3E2	FASTA	1,913	205,151
	10 20 30 40 50 60 MRELEAKATK DVERNLSRDL VQEEEQLMEE KKKKKDDKKK KEAAQKKATE QKIKVPEQIK 70 80 90 100 110 120 PSVSQPQPAN SNNGTSTATS TNNNAKRATA NNQQPQQQQQ QQQPQQQQPQ QQPQPQPQQQ 130 140 150 160 170 180 QPQQQPQALP RYPREVPPRF RHQEHKQLLK RGQHFPVIAA NLGSAVKVLN SQSESSALTN 190 200 210 220 230 240 QQPQNNGEVQ NSKNQSDINH STSGSHYENS QRGPVSSTSD SSTNCKNAVV SDLSEKEAWP 250 260 270 280 290 300 SAPGSDPELA SECMDADSAS SSESERNITI MASGNTGGEK DGLRNSTGLG SQNKFVVGSS 310 320 330 340 350 360 SNNVGHGSST GPWGFSHGAI ISTCQVSVDA PESKSESSNN RMNAWGTVSS SSNGGLNPST 370 380 390 400 410 420 LNSASNHGAW PVLENNGLAL KGPVGSGSSG INIQCSTIGQ MPNNQSINSK VSGGSTHGTW 430 440 450 460 470 480 GSLQETCESE VSGTQKVSFS GQPQNITTEM TGPNNTTNFM TSSLPNSGSV QNNELPSSNT 490 500 510 520 530 540 GAWRVSTMNH PQMQAPSGMN GTSLSHLSNG ESKSGGSYGT TWGAYGSNYS GDKCSGPNGQ 550 560 570 580 590 600 ANGDTVNATL MQPGVNGPMG TNFQVNTNKG GGVWESGAAN SQSTSWGSGN GANSGGSRRG 610 620 630 640 650 660 WGTPAQNTGT NLPSVEWNKL PSNQHSNDSA NGNGKTFTNG WKSTEEEDQG SATSQTNEQS 670 680 690 700 710 720 SVWAKTGGTV ESDGSTESTG RLEEKGTGES QSRDRRKIDQ HTLLQSIVNR TDLDPRVLSN 730 740 750 760 770 780 SGWGQTPIKQ NTAWDTETSP RGERKTDNGT EAWGSSATQT FNSGACIDKT SPNGNDTSSV 790 800 810 820 830 840 SGWGDPKPAL RWGDSKGSNC QGGWEDDSAA TGMVKSNQWG NCKEEKAAWN DSQKNKQGWG 850 860 870 880 890 900 DGQKSSQGWS VSASDNWGET SRNNHWGEAN KKSSSGGSDS DRSVSGWNEL GKTSSFTWGN 910 920 930 940 950 960 NINPNNSSGW DESSKPTPSQ GWGDPPKSNQ SLGWGDSSKP VSSPDWNKQQ DIVGSWGIPP 970 980 990 1000 1010 1020 ATGKPPGTGW LGGPIPAPAK EEEPTGWEEP SPESIRRKME IDDGTSAWGD PSKYNYKNVN 1030 1040 1050 1060 1070 1080 MWNKNVPNGN SRSDQQAQVH QLLTPASAIS NKEASSGSGW GEPWGEPSTP ATTVDNGTSA 1090 1100 1110 1120 1130 1140 WGKPIDSGPS WGEPIAAASS TSTWGSSSVG PQALSKSGPK SMQDGWCGDD MPLPGNRPTG 1150 1160 1170 1180 1190 1200 WEEEEDVEIG MWNSNSSQEL NSSLNWPPYT KKMSSKGLSG KKRRRERGMM KGGNKQEEAW 1210 1220 1230 1240 1250 1260 INPFVKQFSN ISFSRDSPEE NVQSNKMDLS GGMLQDKRME IDKHSLNIGD YNRTVGKGPG 1270 1280 1290 1300 1310 1320 SRPQISKESS MERNPYFDKN GNPSMFGVGN TAAQPRGMQQ PPAQPLSSSQ PNLRAQVPPP 1330 1340 1350 1360 1370 1380 LLSPQVPVSL LKYAPNNGGL NPLFGPQQVA MLNQLSQLNQ LSQISQLQRL LAQQQRAQSQ 1390 1400 1410 1420 1430 1440 RSVPSGNRPQ QDQQGRPLSV QQQMMQQSRQ LDPNLLVKQQ TPPSQQQPLH QPAMKSFLDN 1450 1460 1470 1480 1490 1500 VMPHTTPELQ KGPSPINAFS NFPIGLNSNL NVNMDMNSIK EPQSRLRKWT TVDSISVNTS 1510 1520 1530 1540 1550 1560 LDQNSSKHGA ISSGFRLEES PFVPYDFMNS STSPASPPGS IGDGWPRAKS PNGSSSVNWP 1570 1580 1590 1600 1610 1620 PEFRPGEPWK GYPNIDPETD PYVTPGSVIN NLSINTVREV DHLRDRNSGS SSSLNTTLPS 1630 1640 1650 1660 1670 1680 TSAWSSIRAS NYNVPLSSTA QSTSARNSDS KLTWSPGSVT NTSLAHELWK VPLPPKNITA 1690 1700 1710 1720 1730 1740 PSRPPPGLTG QKPPLSTWDN SPLRIGGGWG NSDARYTPGS SWGESSSGRI TNWLVLKNLT 1750 1760 1770 1780 1790 1800 PQIDGSTLRT LCMQHGPLIT FHLNLPHGNA LVRYSSKEEV VKAQKSLHMC VLGNTTILAE 1810 1820 1830 1840 1850 1860 FASEEEISRF FAQSQSLTPS PGWQSLGSSQ SRLGSLDCSH SFSSRTDLNH WNGAGLSGTN 1870 1880 1890 1900 1910 CGDLHGTSLW GTPHYSTSLW GPPSSSDPRG ISSPSPINAF LSVDHLGGGG ESM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles." Eystathioy T., Chan E.K.L., Tenenbaum S.A., Keene J.D., Griffith K., Fritzler M.J. Mol. Biol. Cell 13:1338-1351(2002) [PubMed: 11950943] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), RNA-BINDING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, PHOSPHORYLATION. Tissue: Cervix carcinoma.
[2]	"Candidate EMSY interactor protein." Hughes-Davies L. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 861-1962 (ISOFORM 6). Tissue: Kidney and Stomach.
[4]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1515-1962. Tissue: Kidney and PNS.
[6]	"cDNAs with long CAG trinucleotide repeats from human brain." Margolis R.L., Abraham M.R., Gatchell S.B., Li S.-H., Kidwai A.S., Breschel T.S., Stine O.C., Callahan C., McInnis M.G., Ross C.A. Hum. Genet. 100:114-122(1997) [PubMed: 9225980] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-157 (ISOFORM 5). Tissue: Brain.
[7]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed: 10819331] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 565-1962. Tissue: Brain.
[8]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1522-1962. Tissue: Ovarian carcinoma.
[9]	"Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182." Eystathioy T., Chan E.K.L., Takeuchi K., Mahler M., Luft L.M., Zochodne D.W., Fritzler M.J. J. Mol. Med. 81:811-818(2003) [PubMed: 14598044] [Abstract] Cited for: AUTOANTIGENIC EPITOPE MAPPING.
[10]	"The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies." Eystathioy T., Jakymiw A., Chan E.K.L., Seraphin B., Cougot N., Fritzler M.J. RNA 9:1171-1173(2003) [PubMed: 13130130] [Abstract] Cited for: SUBCELLULAR LOCATION.
[11]	"GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation." Yang Z., Jakymiw A., Wood M.R., Eystathioy T., Rubin R.L., Fritzler M.J., Chan E.K.L. J. Cell Sci. 117:5567-5578(2004) [PubMed: 15494374] [Abstract] Cited for: SUBCELLULAR LOCATION.
[12]	"Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies." Sen G.L., Blau H.M. Nat. Cell Biol. 7:633-636(2005) [PubMed: 15908945] [Abstract] Cited for: SUBCELLULAR LOCATION.
[13]	"A role for the P-body component GW182 in microRNA function." Liu J., Rivas F.V., Wohlschlegel J., Yates J.R. III, Parker R., Hannon G.J. Nat. Cell Biol. 7:1261-1266(2005) [PubMed: 16284623] [Abstract] Cited for: FUNCTION, INTERACTION WITH EIF2C2, SUBCELLULAR LOCATION.
[14]	"Disruption of GW bodies impairs mammalian RNA interference." Jakymiw A., Lian S.L., Eystathioy T., Li S., Satoh M., Hamel J.C., Fritzler M.J., Chan E.K.L. Nat. Cell Biol. 7:1267-1274(2005) [PubMed: 16284622] [Abstract] Cited for: FUNCTION, INTERACTION WITH EIF2C2, ASSOCIATION WITH SIRNA, SUBCELLULAR LOCATION.
[15]	Erratum Jakymiw A., Lian S.L., Eystathioy T., Li S., Satoh M., Hamel J.C., Fritzler M.J., Chan E.K.L. Nat. Cell Biol. 8:100-100(2006)
[16]	"Formation of GW bodies is a consequence of microRNA genesis." Pauley K.M., Eystathioy T., Jakymiw A., Hamel J.C., Fritzler M.J., Chan E.K.L. EMBO Rep. 7:904-910(2006) [PubMed: 16906129] [Abstract] Cited for: SUBCELLULAR LOCATION, ASSOCIATION WITH MICRORNA.
[17]	"Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system." Wakiyama M., Takimoto K., Ohara O., Yokoyama S. Genes Dev. 21:1857-1862(2007) [PubMed: 17671087] [Abstract] Cited for: FUNCTION.
[18]	Erratum Wakiyama M., Takimoto K., Ohara O., Yokoyama S. Genes Dev. 21:2509-2509(2007)
[19]	"Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies." Lian S.L., Fritzler M.J., Katz J., Hamazaki T., Terada N., Satoh M., Chan E.K.L. Mol. Biol. Cell 18:3375-3387(2007) [PubMed: 17596515] [Abstract] Cited for: FUNCTION.
[20]	Erratum Lian S.L., Fritzler M.J., Katz J., Hamazaki T., Terada N., Satoh M., Chan E.K.L. Mol. Biol. Cell 18:4200-4200(2007)
[21]	"Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing." Li S., Lian S.L., Moser J.J., Fritzler M.L., Fritzler M.J., Satoh M., Chan E.K.L. J. Cell Sci. 121:4134-4144(2008) [PubMed: 19056672] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[22]	"Prolyl 4-hydroxylation regulates Argonaute 2 stability." Qi H.H., Ongusaha P.P., Myllyharju J., Cheng D., Pakkanen O., Shi Y., Lee S.W., Peng J., Shi Y. Nature 455:421-424(2008) [PubMed: 18690212] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH EIF2C2.
[23]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1470, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[24]	"Localization of double-stranded small interfering RNA to cytoplasmic processing bodies is Ago2 dependent and results in up-regulation of GW182 and Argonaute-2." Jagannath A., Wood M.J.A. Mol. Biol. Cell 20:521-529(2009) [PubMed: 18946079] [Abstract] Cited for: SUBCELLULAR LOCATION, INDUCTION.
[25]	"Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression." Zipprich J.T., Bhattacharyya S., Mathys H., Filipowicz W. RNA 15:781-793(2009) [PubMed: 19304925] [Abstract] Cited for: FUNCTION, INTERACTION WITH EIF2C2.
[26]	"The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing." Lian S.L., Li S., Abadal G.X., Pauley B.A., Fritzler M.J., Chan E.K.L. RNA 15:804-813(2009) [PubMed: 19324964] [Abstract] Cited for: INTERACTION WITH EIF2C1; EIF2C2; EIF2C3 AND EIF2C4, SUBCELLULAR LOCATION, MUTAGENESIS OF TRP-313; TRP-345; TRP-370; TRP-420 AND TRP-483.
[27]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1585, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY035864 mRNA. Translation: AAK62026.1. AJ492221 mRNA. Translation: CAD37348.1. AL713750 mRNA. Translation: CAD28525.2. Different initiation. AL833757 mRNA. Translation: CAH56236.1. AC002565 Genomic DNA. No translation available. AC008731 Genomic DNA. No translation available. BC024324 mRNA. Translation: AAH24324.2. BC068209 mRNA. No translation available. U80739 mRNA. Translation: AAB91438.1. AB040893 mRNA. Translation: BAA95984.1. AK001773 mRNA. Translation: BAA91899.1. Different initiation.
IPI	IPI00160265. IPI00382618. IPI00395878. IPI00554606. IPI00554721. IPI00853634.
RefSeq	NP_055309.2. NM_014494.2.
UniGene	Hs.655057.
3D structure databases
ProteinModelPortal	Q8NDV7.
SMR	Q8NDV7. Positions 1186-1258, 1774-1862.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NDV7. 31 interactions.
STRING	Q8NDV7.
PTM databases
PhosphoSite	Q8NDV7.
Polymorphism databases
DMDM	296452846.
Proteomic databases
PRIDE	Q8NDV7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000395799; ENSP00000379144; ENSG00000090905.
GeneID	27327.
KEGG	hsa:27327.
UCSC	uc002dmm.1. human. uc002dmn.1. human. uc002dmr.1. human.
Organism-specific databases
CTD	27327.
GeneCards	GC16P024741.
H-InvDB	HIX0012904.
HGNC	HGNC:11969. TNRC6A.
HPA	HPA015305. HPA017869.
MIM	610739. gene.
neXtProt	NX_Q8NDV7.
PharmGKB	PA36656.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05635.
GeneTree	ENSGT00410000025966.
HOVERGEN	HBG062594.
InParanoid	Q8NDV7.
OMA	WGDSKGS.
Gene expression databases
ArrayExpress	Q8NDV7.
Bgee	Q8NDV7.
Genevestigator	Q8NDV7.
GermOnline	ENSG00000090905. Homo sapiens.
Family and domain databases
InterPro	IPR019486. Argonaute_hook_dom. IPR012677. Nucleotide-bd_a/b_plait. IPR000504. RRM_dom. IPR009060. UBA-like. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit.
Pfam	PF10427. Ago_hook. 1 hit. [Graphical view]
SMART	SM00360. RRM. 1 hit. [Graphical view]
SUPFAM	SSF46934. UBA_like. 1 hit.
PROSITE	PS50102. RRM. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	50354.
SOURCE	Search...

Entry information

Entry name

TNR6A_HUMAN

Accession

Primary (citable) accession number: Q8NDV7
Secondary accession number(s): C9JAR8 , O15408, Q658L5, Q6NVB5, Q8NEZ0, Q8TBT8, Q8TCR0, Q9NV59, Q9P268

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.