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Q8NDV3

- SMC1B_HUMAN

UniProt

Q8NDV3 - SMC1B_HUMAN

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Protein

Structural maintenance of chromosomes protein 1B

Gene

SMC1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 398ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: Ensembl

GO - Biological processi

  1. meiotic nuclear division Source: UniProtKB-KW
  2. sister chromatid cohesion Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Meiosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_75792. Meiotic synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 1B
Short name:
SMC protein 1B
Short name:
SMC-1-beta
Short name:
SMC-1B
Gene namesi
Name:SMC1B
Synonyms:SMC1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:11112. SMC1B.

Subcellular locationi

Nucleus. Chromosome By similarity. Chromosomecentromere By similarity
Note: Associates with chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at the centromeres up to metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes segregation (By similarity).By similarity

GO - Cellular componenti

  1. chromosome, centromeric region Source: UniProtKB-KW
  2. lateral element Source: Ensembl
  3. meiotic cohesin complex Source: UniProtKB
  4. nuclear meiotic cohesin complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35962.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12351235Structural maintenance of chromosomes protein 1BPRO_0000118993Add
BLAST

Proteomic databases

MaxQBiQ8NDV3.
PaxDbiQ8NDV3.
PRIDEiQ8NDV3.

PTM databases

PhosphoSiteiQ8NDV3.

Expressioni

Gene expression databases

BgeeiQ8NDV3.
CleanExiHS_SMC1B.
GenevestigatoriQ8NDV3.

Organism-specific databases

HPAiHPA001500.

Interactioni

Subunit structurei

Forms a heterodimer with SMC3. Component of a meiosis-specific cohesin complex, probably composed of the SMC1B and SMC3 heterodimer attached via their hinge domain, RAD21 (or its meiosis-specific related protein REC8), which link them, and STAG3, which interacts with RAD21 or REC8 (By similarity).By similarity

Protein-protein interaction databases

BioGridi118018. 2 interactions.
STRINGi9606.ENSP00000350036.

Structurei

3D structure databases

ProteinModelPortaliQ8NDV3.
SMRiQ8NDV3. Positions 7-161, 499-675, 1054-1219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni491 – 665175Flexible hingeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili156 – 490335Sequence AnalysisAdd
BLAST
Coiled coili666 – 934269Sequence AnalysisAdd
BLAST
Coiled coili970 – 99425Sequence AnalysisAdd
BLAST
Coiled coili1022 – 104928Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1124 – 115936Ala/Asp-rich (DA-box)Add
BLAST

Domaini

The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 or REC8 protein, forming a ring structure (By similarity).By similarity

Sequence similaritiesi

Belongs to the SMC family. SMC1 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG1196.
HOVERGENiHBG039593.
InParanoidiQ8NDV3.
KOiK06636.
OMAiQLYHNEK.
OrthoDBiEOG7K3TK5.
PhylomeDBiQ8NDV3.
TreeFamiTF101156.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR010935. SMC_hinge.
[Graphical view]
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
SSF75553. SSF75553. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NDV3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHLELLLVE NFKSWRGRQV IGPFRRFTCI IGPNGSGKSN VMDALSFVMG
60 70 80 90 100
EKIANLRVKN IQELIHGAHI GKPISSSASV KIIYVEESGE EKTFARIIRG
110 120 130 140 150
GCSEFRFNDN LVSRSVYIAE LEKIGIIVKA QNCLVFQGTV ESISVKKPKE
160 170 180 190 200
RTQFFEEIST SGELIGEYEE KKRKLQKAEE DAQFNFNKKK NIAAERRQAK
210 220 230 240 250
LEKEEAERYQ SLLEELKMNK IQLQLFQLYH NEKKIHLLNT KLEHVNRDLS
260 270 280 290 300
VKRESLSHHE NIVKARKKEH GMLTRQLQQT EKELKSVETL LNQKRPQYIK
310 320 330 340 350
AKENTSHHLK KLDVAKKSIK DSEKQCSKQE DDIKALETEL ADLDAAWRSF
360 370 380 390 400
EKQIEEEILH KKRDIELEAS QLDRYKELKE QVRKKVATMT QQLEKLQWEQ
410 420 430 440 450
KTDEERLAFE KRRHGEVQGN LKQIKEQIED HKKRIEKLEE YTKTCMDCLK
460 470 480 490 500
EKKQQEETLV DEIEKTKSRM SEFNEELNLI RSELQNAGID THEGKRQQKR
510 520 530 540 550
AEVLEHLKRL YPDSVFGRLF DLCHPIHKKY QLAVTKVFGR FITAIVVASE
560 570 580 590 600
KVAKDCIRFL KEERAEPETF LALDYLDIKP INERLRELKG CKMVIDVIKT
610 620 630 640 650
QFPQLKKVIQ FVCGNGLVCE TMEEARHIAL SGPERQKTVA LDGTLFLKSG
660 670 680 690 700
VISGGSSDLK YKARCWDEKE LKNLRDRRSQ KIQELKGLMK TLRKETDLKQ
710 720 730 740 750
IQTLIQGTQT RLKYSQNELE MIKKKHLVAF YQEQSQLQSE LLNIESQCIM
760 770 780 790 800
LSEGIKERQR RIKEFQEKID KVEDDIFQHF CEEIGVENIR EFENKHVKRQ
810 820 830 840 850
QEIDQKRYFY KKMLTRLNVQ LEYSRSHLKK KLNKINTLKE TIQKGSEDID
860 870 880 890 900
HLKKAEENCL QTVNELMAKQ QQLKDIRVTQ NSSAEKVQTQ IEEERKKFLA
910 920 930 940 950
VDREVGKLQK EVVSIQTSLE QKRLEKHNLL LDCKVQDIEI ILLSGSLDDI
960 970 980 990 1000
IEVEMGTEAE STQATIDIYE KEEAFEIDYS SLKEDLKALQ SDQEIEAHLR
1010 1020 1030 1040 1050
LLLQQVASQE DILLKTAAPN LRALENLKTV RDKFQESTDA FEASRKEARL
1060 1070 1080 1090 1100
CRQEFEQVKK RRYDLFTQCF EHVSISIDQI YKKLCRNNSA QAFLSPENPE
1110 1120 1130 1140 1150
EPYLEGISYN CVAPGKRFMP MDNLSGGEKC VAALALLFAV HSFRPAPFFV
1160 1170 1180 1190 1200
LDEVDAALDN TNIGKVSSYI KEQTQDQFQM IVISLKEEFY SRADALIGIY
1210 1220 1230
PEYDDCMFSR VLTLDLSQYP DTEGQESSKR HGESR
Length:1,235
Mass (Da):143,908
Last modified:January 4, 2005 - v2
Checksum:iA06223197817017F
GO
Isoform 2 (identifier: Q8NDV3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     808-814: YFYKKML → LEFEKQK
     1092-1165: Missing.

Note: No experimental confirmation available.

Show »
Length:1,161
Mass (Da):135,838
Checksum:iAE2578854CC1A3BE
GO
Isoform 3 (identifier: Q8NDV3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     808-814: YFYKKML → LEFEKQK

Note: No experimental confirmation available.

Show »
Length:1,235
Mass (Da):143,837
Checksum:iBF22F243CA070B15
GO

Sequence cautioni

The sequence BAC86266.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991R → L in CAD43404. (PubMed:14660695)Curated
Sequence conflicti731 – 7311Y → D in BAC86266. (PubMed:14702039)Curated
Sequence conflicti752 – 7521S → G in BAC86266. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti473 – 4731F → V.1 Publication
Corresponds to variant rs136603 [ dbSNP | Ensembl ].
VAR_045913
Natural varianti758 – 7581R → Q.
Corresponds to variant rs9614653 [ dbSNP | Ensembl ].
VAR_057324
Natural varianti1008 – 10081S → A.
Corresponds to variant rs16993928 [ dbSNP | Ensembl ].
VAR_057325
Natural varianti1050 – 10501L → M.2 Publications
Corresponds to variant rs5764698 [ dbSNP | Ensembl ].
VAR_045914

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei808 – 8147YFYKKML → LEFEKQK in isoform 2 and isoform 3. 2 PublicationsVSP_035027
Alternative sequencei1092 – 116574Missing in isoform 2. 1 PublicationVSP_035028Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ504806 mRNA. Translation: CAD43404.2.
AL008718, AL021391 Genomic DNA. Translation: CAQ08671.1.
AL008718, AL021391 Genomic DNA. Translation: CAQ08672.1.
BC126208 mRNA. Translation: AAI26209.1.
AK125736 mRNA. Translation: BAC86266.1. Different initiation.
CCDSiCCDS43027.1. [Q8NDV3-3]
CCDS74876.1. [Q8NDV3-2]
RefSeqiNP_001278430.1. NM_001291501.1.
NP_683515.4. NM_148674.4.
UniGeneiHs.334176.

Genome annotation databases

EnsembliENST00000357450; ENSP00000350036; ENSG00000077935.
ENST00000404354; ENSP00000385902; ENSG00000077935.
GeneIDi27127.
KEGGihsa:27127.
UCSCiuc003bgc.3. human. [Q8NDV3-3]
uc003bgd.3. human. [Q8NDV3-2]

Polymorphism databases

DMDMi57015410.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ504806 mRNA. Translation: CAD43404.2 .
AL008718 , AL021391 Genomic DNA. Translation: CAQ08671.1 .
AL008718 , AL021391 Genomic DNA. Translation: CAQ08672.1 .
BC126208 mRNA. Translation: AAI26209.1 .
AK125736 mRNA. Translation: BAC86266.1 . Different initiation.
CCDSi CCDS43027.1. [Q8NDV3-3 ]
CCDS74876.1. [Q8NDV3-2 ]
RefSeqi NP_001278430.1. NM_001291501.1.
NP_683515.4. NM_148674.4.
UniGenei Hs.334176.

3D structure databases

ProteinModelPortali Q8NDV3.
SMRi Q8NDV3. Positions 7-161, 499-675, 1054-1219.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118018. 2 interactions.
STRINGi 9606.ENSP00000350036.

PTM databases

PhosphoSitei Q8NDV3.

Polymorphism databases

DMDMi 57015410.

Proteomic databases

MaxQBi Q8NDV3.
PaxDbi Q8NDV3.
PRIDEi Q8NDV3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357450 ; ENSP00000350036 ; ENSG00000077935 .
ENST00000404354 ; ENSP00000385902 ; ENSG00000077935 .
GeneIDi 27127.
KEGGi hsa:27127.
UCSCi uc003bgc.3. human. [Q8NDV3-3 ]
uc003bgd.3. human. [Q8NDV3-2 ]

Organism-specific databases

CTDi 27127.
GeneCardsi GC22M045739.
H-InvDB HIX0027884.
HGNCi HGNC:11112. SMC1B.
HPAi HPA001500.
MIMi 608685. gene.
neXtProti NX_Q8NDV3.
PharmGKBi PA35962.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1196.
HOVERGENi HBG039593.
InParanoidi Q8NDV3.
KOi K06636.
OMAi QLYHNEK.
OrthoDBi EOG7K3TK5.
PhylomeDBi Q8NDV3.
TreeFami TF101156.

Enzyme and pathway databases

Reactomei REACT_75792. Meiotic synapsis.

Miscellaneous databases

GeneWikii SMC1B.
GenomeRNAii 27127.
NextBioi 49836.
PROi Q8NDV3.
SOURCEi Search...

Gene expression databases

Bgeei Q8NDV3.
CleanExi HS_SMC1B.
Genevestigatori Q8NDV3.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
InterProi IPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR010935. SMC_hinge.
[Graphical view ]
Pfami PF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF005719. SMC. 1 hit.
SMARTi SM00968. SMC_hinge. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 4 hits.
SSF75553. SSF75553. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The evolution of SMC proteins: phylogenetic analysis and structural implications."
    Cobbe N., Heck M.M.S.
    Mol. Biol. Evol. 21:332-347(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS VAL-473 AND MET-1050.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 731-1235 (ISOFORM 3), VARIANT MET-1050.
    Tissue: Testis.

Entry informationi

Entry nameiSMC1B_HUMAN
AccessioniPrimary (citable) accession number: Q8NDV3
Secondary accession number(s): A0AV46
, B0QY23, B0QY24, Q5TIC3, Q6ZUF9, Q9Y3G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: January 4, 2005
Last modified: November 26, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3