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Protein

G-protein coupled receptor 26

Gene

GPR26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 26
Gene namesi
Name:GPR26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000154478.3
HGNCiHGNC:4481 GPR26
MIMi604847 gene
neXtProtiNX_Q8NDV2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10ExtracellularSequence analysis10
Transmembranei11 – 31Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini32 – 47CytoplasmicSequence analysisAdd BLAST16
Transmembranei48 – 68Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini69 – 81ExtracellularSequence analysisAdd BLAST13
Transmembranei82 – 102Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini103 – 123CytoplasmicSequence analysisAdd BLAST21
Transmembranei124 – 144Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini145 – 168ExtracellularSequence analysisAdd BLAST24
Transmembranei169 – 189Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini190 – 245CytoplasmicSequence analysisAdd BLAST56
Transmembranei246 – 266Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini267 – 276ExtracellularSequence analysis10
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 337CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi104R → A: No effect on constitutive activity; when associated with E-236. 1 Publication1
Mutagenesisi104R → Q or E: No effect on constitutive activity. 1 Publication1
Mutagenesisi104R → Q: No effect on constitutive activity; when associated with E-236. 1 Publication1
Mutagenesisi236R → A or Q: No effect on constitutive activity. 1 Publication1
Mutagenesisi236R → E: No effect on constitutive activity; when associated with A-104. No effect on constitutive activity; when associated with Q-104. 1 Publication1

Organism-specific databases

DisGeNETi2849
OpenTargetsiENSG00000154478
PharmGKBiPA28869

Polymorphism and mutation databases

BioMutaiGPR26
DMDMi37537804

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695451 – 337G-protein coupled receptor 26Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi79 ↔ 156PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NDV2
PRIDEiQ8NDV2

Expressioni

Tissue specificityi

Highly expressed in the CNS, the highest expression is seen in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. Down-regulated in glioblastoma.2 Publications

Gene expression databases

BgeeiENSG00000154478
CleanExiHS_GPR26
GenevisibleiQ8NDV2 HS

Organism-specific databases

HPAiHPA062736

Interactioni

Protein-protein interaction databases

BioGridi109108, 1 interactor
CORUMiQ8NDV2
STRINGi9606.ENSP00000284674

Structurei

3D structure databases

ProteinModelPortaliQ8NDV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00390000005107
HOGENOMiHOG000059564
HOVERGENiHBG051804
InParanoidiQ8NDV2
KOiK08411
OMAiSYHSKMR
OrthoDBiEOG091G0BFV
PhylomeDBiQ8NDV2
TreeFamiTF332434

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NDV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSWDAGLAG LLVGTMGVSL LSNALVLLCL LHSADIRRQA PALFTLNLTC
60 70 80 90 100
GNLLCTVVNM PLTLAGVVAQ RQPAGDRLCR LAAFLDTFLA ANSMLSMAAL
110 120 130 140 150
SIDRWVAVVF PLSYRAKMRL RDAALMVAYT WLHALTFPAA ALALSWLGFH
160 170 180 190 200
QLYASCTLCS RRPDERLRFA VFTGAFHALS FLLSFVVLCC TYLKVLKVAR
210 220 230 240 250
FHCKRIDVIT MQTLVLLVDL HPSVRERCLE EQKRRRQRAT KKISTFIGTF
260 270 280 290 300
LVCFAPYVIT RLVELFSTVP IGSHWGVLSK CLAYSKAASD PFVYSLLRHQ
310 320 330
YRKSCKEILN RLLHRRSIHS SGLTGDSHSQ NILPVSE
Length:337
Mass (Da):37,604
Last modified:October 1, 2002 - v1
Checksum:i4E04D371505F6D01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ505757 mRNA Translation: CAD44281.1
BC112011 mRNA Translation: AAI12012.1
BC113462 mRNA Translation: AAI13463.1
CCDSiCCDS7636.1
RefSeqiNP_703143.1, NM_153442.3
UniGeneiHs.12751

Genome annotation databases

EnsembliENST00000284674; ENSP00000284674; ENSG00000154478
GeneIDi2849
KEGGihsa:2849
UCSCiuc001lhh.4 human

Similar proteinsi

Entry informationi

Entry nameiGPR26_HUMAN
AccessioniPrimary (citable) accession number: Q8NDV2
Secondary accession number(s): Q2M2E2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health