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Protein

G-protein coupled receptor 26

Gene

GPR26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
  • regulation of protein stability Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 26
Gene namesi
Name:GPR26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:4481. GPR26.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010ExtracellularSequence analysis
Transmembranei11 – 3121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini32 – 4716CytoplasmicSequence analysisAdd
BLAST
Transmembranei48 – 6821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini69 – 8113ExtracellularSequence analysisAdd
BLAST
Transmembranei82 – 10221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini103 – 12321CytoplasmicSequence analysisAdd
BLAST
Transmembranei124 – 14421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini145 – 16824ExtracellularSequence analysisAdd
BLAST
Transmembranei169 – 18921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini190 – 24556CytoplasmicSequence analysisAdd
BLAST
Transmembranei246 – 26621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini267 – 27610ExtracellularSequence analysis
Transmembranei277 – 29721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini298 – 33740CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi104 – 1041R → A: No effect on constitutive activity; when associated with E-236. 1 Publication
Mutagenesisi104 – 1041R → Q or E: No effect on constitutive activity. 1 Publication
Mutagenesisi104 – 1041R → Q: No effect on constitutive activity; when associated with E-236. 1 Publication
Mutagenesisi236 – 2361R → A or Q: No effect on constitutive activity. 1 Publication
Mutagenesisi236 – 2361R → E: No effect on constitutive activity; when associated with A-104. No effect on constitutive activity; when associated with Q-104. 1 Publication

Organism-specific databases

PharmGKBiPA28869.

Polymorphism and mutation databases

BioMutaiGPR26.
DMDMi37537804.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337G-protein coupled receptor 26PRO_0000069545Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi79 ↔ 156PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NDV2.
PRIDEiQ8NDV2.

PTM databases

PhosphoSiteiQ8NDV2.

Expressioni

Tissue specificityi

Highly expressed in the CNS, the highest expression is seen in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. Down-regulated in glioblastoma.2 Publications

Gene expression databases

BgeeiQ8NDV2.
CleanExiHS_GPR26.
GenevisibleiQ8NDV2. HS.

Interactioni

Protein-protein interaction databases

BioGridi109108. 1 interaction.
STRINGi9606.ENSP00000284674.

Structurei

3D structure databases

ProteinModelPortaliQ8NDV2.
SMRiQ8NDV2. Positions 11-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000005107.
HOGENOMiHOG000059564.
HOVERGENiHBG051804.
InParanoidiQ8NDV2.
KOiK08411.
OMAiTQFVIFT.
OrthoDBiEOG7HMS1F.
PhylomeDBiQ8NDV2.
TreeFamiTF332434.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NDV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSWDAGLAG LLVGTMGVSL LSNALVLLCL LHSADIRRQA PALFTLNLTC
60 70 80 90 100
GNLLCTVVNM PLTLAGVVAQ RQPAGDRLCR LAAFLDTFLA ANSMLSMAAL
110 120 130 140 150
SIDRWVAVVF PLSYRAKMRL RDAALMVAYT WLHALTFPAA ALALSWLGFH
160 170 180 190 200
QLYASCTLCS RRPDERLRFA VFTGAFHALS FLLSFVVLCC TYLKVLKVAR
210 220 230 240 250
FHCKRIDVIT MQTLVLLVDL HPSVRERCLE EQKRRRQRAT KKISTFIGTF
260 270 280 290 300
LVCFAPYVIT RLVELFSTVP IGSHWGVLSK CLAYSKAASD PFVYSLLRHQ
310 320 330
YRKSCKEILN RLLHRRSIHS SGLTGDSHSQ NILPVSE
Length:337
Mass (Da):37,604
Last modified:October 1, 2002 - v1
Checksum:i4E04D371505F6D01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ505757 mRNA. Translation: CAD44281.1.
BC112011 mRNA. Translation: AAI12012.1.
BC113462 mRNA. Translation: AAI13463.1.
CCDSiCCDS7636.1.
RefSeqiNP_703143.1. NM_153442.3.
UniGeneiHs.12751.

Genome annotation databases

EnsembliENST00000284674; ENSP00000284674; ENSG00000154478.
GeneIDi2849.
KEGGihsa:2849.
UCSCiuc001lhh.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ505757 mRNA. Translation: CAD44281.1.
BC112011 mRNA. Translation: AAI12012.1.
BC113462 mRNA. Translation: AAI13463.1.
CCDSiCCDS7636.1.
RefSeqiNP_703143.1. NM_153442.3.
UniGeneiHs.12751.

3D structure databases

ProteinModelPortaliQ8NDV2.
SMRiQ8NDV2. Positions 11-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109108. 1 interaction.
STRINGi9606.ENSP00000284674.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NDV2.

Polymorphism and mutation databases

BioMutaiGPR26.
DMDMi37537804.

Proteomic databases

PaxDbiQ8NDV2.
PRIDEiQ8NDV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284674; ENSP00000284674; ENSG00000154478.
GeneIDi2849.
KEGGihsa:2849.
UCSCiuc001lhh.4. human.

Organism-specific databases

CTDi2849.
GeneCardsiGPR26.
HGNCiHGNC:4481. GPR26.
MIMi604847. gene.
neXtProtiNX_Q8NDV2.
PharmGKBiPA28869.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000005107.
HOGENOMiHOG000059564.
HOVERGENiHBG051804.
InParanoidiQ8NDV2.
KOiK08411.
OMAiTQFVIFT.
OrthoDBiEOG7HMS1F.
PhylomeDBiQ8NDV2.
TreeFamiTF332434.

Miscellaneous databases

GeneWikiiGPR26.
GenomeRNAii2849.
NextBioi11239.
PROiQ8NDV2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NDV2.
CleanExiHS_GPR26.
GenevisibleiQ8NDV2. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of the human homologue of the rat orphan G protein-coupled receptor GPR26 mRNA."
    Jones G., Boulay J.L., Maier D., Merlo A.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The 10q25.3-26.1 gene encoding the orphan G protein-coupled receptor GPR26 is epigenetically silenced in human gliomas."
    Boulay J.L., Labuhn M., Jones G., Maier D., Merlo A.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78."
    Jones P.G., Nawoschik S.P., Sreekumar K., Uveges A.J., Tseng E., Zhang L., Johnson J., He L., Paulsen J.E., Bates B., Pausch M.H.
    Biochim. Biophys. Acta 1770:890-901(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-104 AND ARG-236.
  5. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiGPR26_HUMAN
AccessioniPrimary (citable) accession number: Q8NDV2
Secondary accession number(s): Q2M2E2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.