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Protein

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

Gene

ST6GALNAC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity).By similarity

Catalytic activityi

CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • glycoprotein metabolic process Source: BHF-UCL
  • glycosphingolipid metabolic process Source: BHF-UCL
  • glycosylceramide metabolic process Source: BHF-UCL
  • oligosaccharide metabolic process Source: GO_Central
  • protein N-linked glycosylation via asparagine Source: GO_Central

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.99.7 2681
ReactomeiR-HSA-4085001 Sialic acid metabolism
R-HSA-977068 Termination of O-glycan biosynthesis
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT29 Glycosyltransferase Family 29

Chemistry databases

SwissLipidsiSLP:000001364 [Q8NDV1-1]
SLP:000001373

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (EC:2.4.99.-)
Alternative name(s):
GalNAc alpha-2,6-sialyltransferase III
ST6GalNAc III
Short name:
ST6GalNAcIII
STY
Sialyltransferase 7C
Short name:
SIAT7-C
Gene namesi
Name:ST6GALNAC3
Synonyms:SIAT7C
ORF Names:UNQ2787/PRO7177
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000184005.10
HGNCiHGNC:19343 ST6GALNAC3
MIMi610133 gene
neXtProtiNX_Q8NDV1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 28Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini29 – 305LumenalSequence analysisAdd BLAST277

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi256435
OpenTargetsiENSG00000184005
PharmGKBiPA134984080

Polymorphism and mutation databases

BioMutaiST6GALNAC3
DMDMi48428651

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492751 – 305Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 229By similarity
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8NDV1
PaxDbiQ8NDV1
PeptideAtlasiQ8NDV1
PRIDEiQ8NDV1

Expressioni

Gene expression databases

BgeeiENSG00000184005
CleanExiHS_ST6GALNAC3
ExpressionAtlasiQ8NDV1 baseline and differential
GenevisibleiQ8NDV1 HS

Organism-specific databases

HPAiHPA054566
HPA055399

Interactioni

Protein-protein interaction databases

BioGridi129166, 16 interactors
IntActiQ8NDV1, 1 interactor
STRINGi9606.ENSP00000329214

Structurei

3D structure databases

ProteinModelPortaliQ8NDV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692 Eukaryota
ENOG410XT8P LUCA
GeneTreeiENSGT00550000074444
HOGENOMiHOG000293316
HOVERGENiHBG058710
InParanoidiQ8NDV1
KOiK03373
OMAiRPLRTHY
OrthoDBiEOG091G0H9S
PhylomeDBiQ8NDV1
TreeFamiTF352818

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
IPR012163 Sialyl_trans
PfamiView protein in Pfam
PF00777 Glyco_transf_29, 1 hit
PIRSFiPIRSF005557 Sialyl_trans, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NDV1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACILKRKSV IAVSFIAAFL FLLVVRLVNE VNFPLLLNCF GQPGTKWIPF
60 70 80 90 100
SYTYRRPLRT HYGYINVKTQ EPLQLDCDLC AIVSNSGQMV GQKVGNEIDR
110 120 130 140 150
SSCIWRMNNA PTKGYEEDVG RMTMIRVVSH TSVPLLLKNP DYFFKEANTT
160 170 180 190 200
IYVIWGPFRN MRKDGNGIVY NMLKKTVGIY PNAQIYVTTE KRMSYCDGVF
210 220 230 240 250
KKETGKDRVQ SGSYLSTGWF TFLLAMDACY GIHVYGMIND TYCKTEGYRK
260 270 280 290 300
VPYHYYEQGR DECDEYFLHE HAPYGGHRFI TEKKVFAKWA KKHRIIFTHP

NWTLS
Length:305
Mass (Da):35,395
Last modified:October 1, 2002 - v1
Checksum:i700BFC6A48F8AD3A
GO
Isoform 2 (identifier: Q8NDV1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     208-210: RVQ → STE
     211-305: Missing.

Show »
Length:210
Mass (Da):24,022
Checksum:i7279EB228B129E75
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169V → I in BAC03611 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055846223L → I2 PublicationsCorresponds to variant dbSNP:rs1184626Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013218208 – 210RVQ → STE in isoform 2. 1 Publication3
Alternative sequenceiVSP_013219211 – 305Missing in isoform 2. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ507291 mRNA Translation: CAD45371.1
AK091215 mRNA Translation: BAC03611.1
AY358540 mRNA Translation: AAQ88904.1
CH471059 Genomic DNA Translation: EAX06388.1
BC059363 mRNA Translation: AAH59363.1
CCDSiCCDS672.1 [Q8NDV1-1]
RefSeqiNP_001153483.1, NM_001160011.1 [Q8NDV1-2]
NP_694541.2, NM_152996.2 [Q8NDV1-1]
UniGeneiHs.337040
Hs.677241
Hs.679096

Genome annotation databases

EnsembliENST00000328299; ENSP00000329214; ENSG00000184005 [Q8NDV1-1]
GeneIDi256435
KEGGihsa:256435
UCSCiuc001dhh.3 human [Q8NDV1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSIA7C_HUMAN
AccessioniPrimary (citable) accession number: Q8NDV1
Secondary accession number(s): Q6PCE0, Q6UX29, Q8N259
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health