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Q8NDT2

- RB15B_HUMAN

UniProt

Q8NDT2 - RB15B_HUMAN

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Protein

Putative RNA-binding protein 15B

Gene

RBM15B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May function in the regulation of alternative or illicit splicing.1 Publication

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. poly(A) RNA binding Source: UniProtKB
  3. RNA binding Source: UniProtKB

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. RNA splicing Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
  6. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, mRNA processing, mRNA splicing, Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA-binding protein 15B
Alternative name(s):
One-twenty two protein 3
Short name:
HuOTT3
RNA-binding motif protein 15B
Gene namesi
Name:RBM15B
Synonyms:OTT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:24303. RBM15B.

Subcellular locationi

Nucleusnucleoplasm 1 Publication
Note: Colocalizes with BMLF1 in the nucleus. Localized in the nucleoplasm with a granular staining pattern and excluded from the nucleoli.

GO - Cellular componenti

  1. nucleoplasm Source: UniProtKB
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134870079.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 890890Putative RNA-binding protein 15BPRO_0000081778Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091Phosphoserine2 Publications
Modified residuei267 – 2671Phosphoserine1 Publication
Modified residuei552 – 5521Phosphoserine2 Publications
Modified residuei562 – 5621Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8NDT2.
PaxDbiQ8NDT2.
PeptideAtlasiQ8NDT2.
PRIDEiQ8NDT2.

PTM databases

PhosphoSiteiQ8NDT2.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ8NDT2.
CleanExiHS_RBM15B.
GenevestigatoriQ8NDT2.

Organism-specific databases

HPAiHPA036645.

Interactioni

Subunit structurei

Interacts (via the SPOC domain) with Epstein-Barr virus BMLF1 (via the N-terminus); the interaction is direct. May interact with NCOR2.1 Publication

Protein-protein interaction databases

BioGridi118943. 17 interactions.
IntActiQ8NDT2. 5 interactions.
STRINGi9606.ENSP00000313890.

Structurei

3D structure databases

ProteinModelPortaliQ8NDT2.
SMRiQ8NDT2. Positions 138-217, 324-493, 722-866.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini139 – 21981RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini337 – 41478RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini418 – 49275RRM 3PROSITE-ProRule annotationAdd
BLAST
Domaini711 – 889179SPOCPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni722 – 890169Interaction with Epstein-Barr virus BMLF1Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi593 – 5975Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi658 – 67720His-richAdd
BLAST

Sequence similaritiesi

Belongs to the RRM Spen family.Curated
Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation
Contains 1 SPOC domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG250829.
GeneTreeiENSGT00530000063730.
HOGENOMiHOG000006547.
HOVERGENiHBG058366.
InParanoidiQ8NDT2.
KOiK13190.
OMAiKRDSERN.
OrthoDBiEOG7QZG9W.
PhylomeDBiQ8NDT2.
TreeFamiTF354224.

Family and domain databases

Gene3Di2.40.290.10. 1 hit.
3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR012921. SPOC_C.
IPR016194. SPOC_like_C_dom.
IPR010912. SPOC_met.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
PF07744. SPOC. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF100939. SSF100939. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
PS50917. SPOC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NDT2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRQSERDSS PSGRGSSSSA KRPREREREA EAGGRRAAHK ASGGAKHPVP
60 70 80 90 100
ARARDKPRGS GSGGGGHRDG RGTGDANHRA SSGRSSGSGA GGGGRGGKAS
110 120 130 140 150
GDPGASGMSP RASPLPPPPP PPGAEPACPG SSAAAPEYKT LLISSLSPAL
160 170 180 190 200
PAEHLEDRLF HQFKRFGEIS LRLSHTPELG RVAYVNFRHP QDAREARQHA
210 220 230 240 250
LARQLLLYDR PLKVEPVYLR GGGGSSRRSS SSSAAASTPP PGPPAPADPL
260 270 280 290 300
GYLPLHGGYQ YKQRSLSPVA APPLREPRAR HAAAAFALDA AAAAAVGLSR
310 320 330 340 350
ERALDYYGLY DDRGRPYGYP AVCEEDLMPE DDQRATRNLF IGNLDHSVSE
360 370 380 390 400
VELRRAFEKY GIIEEVVIKR PARGQGGAYA FLKFQNLDMA HRAKVAMSGR
410 420 430 440 450
VIGRNPIKIG YGKANPTTRL WVGGLGPNTS LAALAREFDR FGSIRTIDHV
460 470 480 490 500
KGDSFAYIQY ESLDAAQAAC AKMRGFPLGG PDRRLRVDFA KAEETRYPQQ
510 520 530 540 550
YQPSPLPVHY ELLTDGYTRH RNLDADLVRD RTPPHLLYSD RDRTFLEGDW
560 570 580 590 600
TSPSKSSDRR NSLEGYSRSV RSRSGERWGA DGDRGLPKPW EERRKRRSLS
610 620 630 640 650
SDRGRTTHSP YEERSRTKGS GQQSERGSDR TPERSRKENH SSEGTKESSS
660 670 680 690 700
NSLSNSRHGA EERGHHHHHH EAADSSHGKK ARDSERNHRT TEAEPKPLEE
710 720 730 740 750
PKHETKKLKN LSEYAQTLQL GWNGLLVLKN SCFPTSMHIL EGDQGVISSL
760 770 780 790 800
LKDHTSGSKL TQLKIAQRLR LDQPKLDEVT RRIKQGSPNG YAVLLATQAT
810 820 830 840 850
PSGLGTEGMP TVEPGLQRRL LRNLVSYLKQ KQAAGVISLP VGGSKGRDGT
860 870 880 890
GMLYAFPPCD FSQQYLQSAL RTLGKLEEEH MVIVIVRDTA
Length:890
Mass (Da):97,205
Last modified:May 5, 2009 - v3
Checksum:i276C94252F036C83
GO
Isoform 2 (identifier: Q8NDT2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-327: Missing.

Note: No experimental confirmation available.

Show »
Length:563
Mass (Da):63,156
Checksum:i310F8918227B576B
GO

Sequence cautioni

The sequence AAH01367.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAS50153.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated
The sequence CAD38547.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti593 – 5931R → K in AAI39837. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 327327Missing in isoform 2. 1 PublicationVSP_053878Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092037 Genomic DNA. No translation available.
BC001367 mRNA. Translation: AAH01367.2. Different initiation.
BC139836 mRNA. Translation: AAI39837.1.
AL831838 mRNA. Translation: CAD38547.2. Different initiation.
AY545557 mRNA. Translation: AAS50153.1. Sequence problems.
CCDSiCCDS33764.1. [Q8NDT2-1]
RefSeqiNP_037418.3. NM_013286.4. [Q8NDT2-1]
UniGeneiHs.118738.
Hs.716623.
Hs.731737.

Genome annotation databases

EnsembliENST00000563281; ENSP00000454545; ENSG00000259956. [Q8NDT2-1]
GeneIDi29890.
KEGGihsa:29890.
UCSCiuc003dbd.3. human. [Q8NDT2-1]

Polymorphism databases

DMDMi229463030.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092037 Genomic DNA. No translation available.
BC001367 mRNA. Translation: AAH01367.2 . Different initiation.
BC139836 mRNA. Translation: AAI39837.1 .
AL831838 mRNA. Translation: CAD38547.2 . Different initiation.
AY545557 mRNA. Translation: AAS50153.1 . Sequence problems.
CCDSi CCDS33764.1. [Q8NDT2-1 ]
RefSeqi NP_037418.3. NM_013286.4. [Q8NDT2-1 ]
UniGenei Hs.118738.
Hs.716623.
Hs.731737.

3D structure databases

ProteinModelPortali Q8NDT2.
SMRi Q8NDT2. Positions 138-217, 324-493, 722-866.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118943. 17 interactions.
IntActi Q8NDT2. 5 interactions.
STRINGi 9606.ENSP00000313890.

PTM databases

PhosphoSitei Q8NDT2.

Polymorphism databases

DMDMi 229463030.

Proteomic databases

MaxQBi Q8NDT2.
PaxDbi Q8NDT2.
PeptideAtlasi Q8NDT2.
PRIDEi Q8NDT2.

Protocols and materials databases

DNASUi 29890.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000563281 ; ENSP00000454545 ; ENSG00000259956 . [Q8NDT2-1 ]
GeneIDi 29890.
KEGGi hsa:29890.
UCSCi uc003dbd.3. human. [Q8NDT2-1 ]

Organism-specific databases

CTDi 29890.
GeneCardsi GC03P051428.
HGNCi HGNC:24303. RBM15B.
HPAi HPA036645.
MIMi 612602. gene.
neXtProti NX_Q8NDT2.
PharmGKBi PA134870079.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG250829.
GeneTreei ENSGT00530000063730.
HOGENOMi HOG000006547.
HOVERGENi HBG058366.
InParanoidi Q8NDT2.
KOi K13190.
OMAi KRDSERN.
OrthoDBi EOG7QZG9W.
PhylomeDBi Q8NDT2.
TreeFami TF354224.

Miscellaneous databases

ChiTaRSi RBM15B. human.
GenomeRNAii 29890.
NextBioi 35461874.
PROi Q8NDT2.
SOURCEi Search...

Gene expression databases

Bgeei Q8NDT2.
CleanExi HS_RBM15B.
Genevestigatori Q8NDT2.

Family and domain databases

Gene3Di 2.40.290.10. 1 hit.
3.30.70.330. 3 hits.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR012921. SPOC_C.
IPR016194. SPOC_like_C_dom.
IPR010912. SPOC_met.
[Graphical view ]
Pfami PF00076. RRM_1. 2 hits.
PF07744. SPOC. 1 hit.
[Graphical view ]
SMARTi SM00360. RRM. 3 hits.
[Graphical view ]
SUPFAMi SSF100939. SSF100939. 1 hit.
PROSITEi PS50102. RRM. 3 hits.
PS50917. SPOC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-890 (ISOFORM 1).
    Tissue: Brain.
  4. Sales M.M., Ferrasi A.C., Pereira A.A., Pardini M.I.M.C., Camargo A.A.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 633-780.
    Tissue: Head.
  5. "Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export."
    Hiriart E., Gruffat H., Buisson M., Mikaelian I., Keppler S., Meresse P., Mercher T., Bernard O.A., Sergeant A., Manet E.
    J. Biol. Chem. 280:36935-36945(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EPSTEIN-BARR VIRUS BMLF1 AND NCOR2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109 AND SER-552, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109; SER-552 AND SER-562, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRB15B_HUMAN
AccessioniPrimary (citable) accession number: Q8NDT2
Secondary accession number(s): A4QPG7, Q6QE19, Q9BV96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: May 5, 2009
Last modified: November 26, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3