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Protein

Zinc finger protein 439

Gene

ZNF439

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri186 – 20823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 49025C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 439
Gene namesi
Name:ZNF439
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20873. ZNF439.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134886330.

Polymorphism and mutation databases

BioMutaiZNF439.
DMDMi30580628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Zinc finger protein 439PRO_0000047588Add
BLAST

Proteomic databases

PaxDbiQ8NDP4.
PeptideAtlasiQ8NDP4.
PRIDEiQ8NDP4.

PTM databases

iPTMnetiQ8NDP4.
PhosphoSiteiQ8NDP4.

Expressioni

Gene expression databases

BgeeiENSG00000171291.
CleanExiHS_ZNF439.
ExpressionAtlasiQ8NDP4. baseline and differential.
GenevisibleiQ8NDP4. HS.

Organism-specific databases

HPAiHPA047845.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-747580,EBI-748961
CEP70Q8NHQ13EBI-747580,EBI-739624
GMNNO754963EBI-747580,EBI-371669
KRT40Q6A1623EBI-747580,EBI-10171697
KRTAP10-5P603703EBI-747580,EBI-10172150
KRTAP10-7P604093EBI-747580,EBI-10172290
KRTAP10-8P604103EBI-747580,EBI-10171774
KRTAP10-9P604113EBI-747580,EBI-10172052
KRTAP5-9P263713EBI-747580,EBI-3958099
MDFIQ997505EBI-747580,EBI-724076
MTUS2Q5JR594EBI-747580,EBI-742948
NOTCH2NLQ7Z3S93EBI-747580,EBI-945833

Protein-protein interaction databases

BioGridi124741. 15 interactions.
IntActiQ8NDP4. 14 interactions.
MINTiMINT-1475050.
STRINGi9606.ENSP00000305077.

Structurei

3D structure databases

ProteinModelPortaliQ8NDP4.
SMRiQ8NDP4. Positions 19-68, 156-494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 10183KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri186 – 20823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri214 – 23623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri242 – 26423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 49025C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8NDP4.
KOiK09228.
OMAiCHRHERS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8NDP4.
TreeFamiTF338854.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NDP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLSPILLY TCEMFQDPVA FKDVAVNFTQ EEWALLDISQ KNLYREVMLE
60 70 80 90 100
TFWNLTSIGK KWKDQNIEYE YQNPRRNFRS VTEEKVNEIK EDSHCGETFT
110 120 130 140 150
PVPDDRLNFQ KKKASPEVKS CDSFVCEVGL GNSSSNMNIR GDTGHKACEC
160 170 180 190 200
QEYGPKPWKS QQPKKAFRYH PSLRTQERDH TGKKPYACKE CGKNIIYHSS
210 220 230 240 250
IQRHMVVHSG DGPYKCKFCG KAFHCLSLYL IHERTHTGEK PYECKQCGKS
260 270 280 290 300
FSYSATHRIH ERTHIGEKPY ECQECGKAFH SPRSCHRHER SHMGEKAYQC
310 320 330 340 350
KECGKAFMCP RYVRRHERTH SRKKLYECKQ CGKALSSLTS FQTHIRMHSG
360 370 380 390 400
ERPYECKTCG KGFYSAKSFQ RHEKTHSGEK PYKCKQCGKA FTRSGSFRYH
410 420 430 440 450
ERTHTGEKPY ECKQCGKAFR SAPNLQLHGR THTGEKPYQC KECGKAFRSA
460 470 480 490
SQLRIHRRIH TGEKPYECKK CGKAFRYVQN FRFHERTQTH KNALWRKTL
Length:499
Mass (Da):58,395
Last modified:October 1, 2002 - v1
Checksum:i483E3238E280F229
GO

Sequence cautioni

The sequence BAB55187 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61P → S.
Corresponds to variant rs10421552 [ dbSNP | Ensembl ].
VAR_052827
Natural varianti427 – 4271L → S.1 Publication
Corresponds to variant rs10500209 [ dbSNP | Ensembl ].
VAR_024216

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833935 mRNA. Translation: CAD38790.1.
AK027542 mRNA. Translation: BAB55187.1. Different initiation.
BC032857 mRNA. Translation: AAH32857.1.
CCDSiCCDS12268.1.
RefSeqiNP_689475.1. NM_152262.2.
UniGeneiHs.528731.

Genome annotation databases

EnsembliENST00000304030; ENSP00000305077; ENSG00000171291.
GeneIDi90594.
KEGGihsa:90594.
UCSCiuc002msr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833935 mRNA. Translation: CAD38790.1.
AK027542 mRNA. Translation: BAB55187.1. Different initiation.
BC032857 mRNA. Translation: AAH32857.1.
CCDSiCCDS12268.1.
RefSeqiNP_689475.1. NM_152262.2.
UniGeneiHs.528731.

3D structure databases

ProteinModelPortaliQ8NDP4.
SMRiQ8NDP4. Positions 19-68, 156-494.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124741. 15 interactions.
IntActiQ8NDP4. 14 interactions.
MINTiMINT-1475050.
STRINGi9606.ENSP00000305077.

PTM databases

iPTMnetiQ8NDP4.
PhosphoSiteiQ8NDP4.

Polymorphism and mutation databases

BioMutaiZNF439.
DMDMi30580628.

Proteomic databases

PaxDbiQ8NDP4.
PeptideAtlasiQ8NDP4.
PRIDEiQ8NDP4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304030; ENSP00000305077; ENSG00000171291.
GeneIDi90594.
KEGGihsa:90594.
UCSCiuc002msr.4. human.

Organism-specific databases

CTDi90594.
GeneCardsiZNF439.
HGNCiHGNC:20873. ZNF439.
HPAiHPA047845.
neXtProtiNX_Q8NDP4.
PharmGKBiPA134886330.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8NDP4.
KOiK09228.
OMAiCHRHERS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8NDP4.
TreeFamiTF338854.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii90594.
PROiQ8NDP4.

Gene expression databases

BgeeiENSG00000171291.
CleanExiHS_ZNF439.
ExpressionAtlasiQ8NDP4. baseline and differential.
GenevisibleiQ8NDP4. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN439_HUMAN
AccessioniPrimary (citable) accession number: Q8NDP4
Secondary accession number(s): Q8IYZ7, Q96SU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.