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Protein

Zinc finger protein 439

Gene

ZNF439

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri186 – 208C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 490C2H2-type 11PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 439
Gene namesi
Name:ZNF439
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20873. ZNF439.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171291.
PharmGKBiPA134886330.

Polymorphism and mutation databases

BioMutaiZNF439.
DMDMi30580628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475881 – 499Zinc finger protein 439Add BLAST499

Proteomic databases

MaxQBiQ8NDP4.
PaxDbiQ8NDP4.
PeptideAtlasiQ8NDP4.
PRIDEiQ8NDP4.

PTM databases

iPTMnetiQ8NDP4.
PhosphoSitePlusiQ8NDP4.

Expressioni

Gene expression databases

BgeeiENSG00000171291.
CleanExiHS_ZNF439.
ExpressionAtlasiQ8NDP4. baseline and differential.
GenevisibleiQ8NDP4. HS.

Organism-specific databases

HPAiHPA047845.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124741. 15 interactors.
IntActiQ8NDP4. 21 interactors.
MINTiMINT-1475050.
STRINGi9606.ENSP00000305077.

Structurei

3D structure databases

ProteinModelPortaliQ8NDP4.
SMRiQ8NDP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 101KRABPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri186 – 208C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 490C2H2-type 11PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8NDP4.
KOiK09228.
OMAiCHRHERS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8NDP4.
TreeFamiTF338854.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 4 hits.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.

Sequencei

Sequence statusi: Complete.

Q8NDP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLSPILLY TCEMFQDPVA FKDVAVNFTQ EEWALLDISQ KNLYREVMLE
60 70 80 90 100
TFWNLTSIGK KWKDQNIEYE YQNPRRNFRS VTEEKVNEIK EDSHCGETFT
110 120 130 140 150
PVPDDRLNFQ KKKASPEVKS CDSFVCEVGL GNSSSNMNIR GDTGHKACEC
160 170 180 190 200
QEYGPKPWKS QQPKKAFRYH PSLRTQERDH TGKKPYACKE CGKNIIYHSS
210 220 230 240 250
IQRHMVVHSG DGPYKCKFCG KAFHCLSLYL IHERTHTGEK PYECKQCGKS
260 270 280 290 300
FSYSATHRIH ERTHIGEKPY ECQECGKAFH SPRSCHRHER SHMGEKAYQC
310 320 330 340 350
KECGKAFMCP RYVRRHERTH SRKKLYECKQ CGKALSSLTS FQTHIRMHSG
360 370 380 390 400
ERPYECKTCG KGFYSAKSFQ RHEKTHSGEK PYKCKQCGKA FTRSGSFRYH
410 420 430 440 450
ERTHTGEKPY ECKQCGKAFR SAPNLQLHGR THTGEKPYQC KECGKAFRSA
460 470 480 490
SQLRIHRRIH TGEKPYECKK CGKAFRYVQN FRFHERTQTH KNALWRKTL
Length:499
Mass (Da):58,395
Last modified:October 1, 2002 - v1
Checksum:i483E3238E280F229
GO

Sequence cautioni

The sequence BAB55187 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0528276P → S. Corresponds to variant dbSNP:rs10421552Ensembl.1
Natural variantiVAR_024216427L → S1 PublicationCorresponds to variant dbSNP:rs10500209Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833935 mRNA. Translation: CAD38790.1.
AK027542 mRNA. Translation: BAB55187.1. Different initiation.
BC032857 mRNA. Translation: AAH32857.1.
CCDSiCCDS12268.1.
RefSeqiNP_689475.1. NM_152262.2.
UniGeneiHs.528731.

Genome annotation databases

EnsembliENST00000304030; ENSP00000305077; ENSG00000171291.
GeneIDi90594.
KEGGihsa:90594.
UCSCiuc002msr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833935 mRNA. Translation: CAD38790.1.
AK027542 mRNA. Translation: BAB55187.1. Different initiation.
BC032857 mRNA. Translation: AAH32857.1.
CCDSiCCDS12268.1.
RefSeqiNP_689475.1. NM_152262.2.
UniGeneiHs.528731.

3D structure databases

ProteinModelPortaliQ8NDP4.
SMRiQ8NDP4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124741. 15 interactors.
IntActiQ8NDP4. 21 interactors.
MINTiMINT-1475050.
STRINGi9606.ENSP00000305077.

PTM databases

iPTMnetiQ8NDP4.
PhosphoSitePlusiQ8NDP4.

Polymorphism and mutation databases

BioMutaiZNF439.
DMDMi30580628.

Proteomic databases

MaxQBiQ8NDP4.
PaxDbiQ8NDP4.
PeptideAtlasiQ8NDP4.
PRIDEiQ8NDP4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304030; ENSP00000305077; ENSG00000171291.
GeneIDi90594.
KEGGihsa:90594.
UCSCiuc002msr.4. human.

Organism-specific databases

CTDi90594.
GeneCardsiZNF439.
HGNCiHGNC:20873. ZNF439.
HPAiHPA047845.
neXtProtiNX_Q8NDP4.
OpenTargetsiENSG00000171291.
PharmGKBiPA134886330.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8NDP4.
KOiK09228.
OMAiCHRHERS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8NDP4.
TreeFamiTF338854.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii90594.
PROiQ8NDP4.

Gene expression databases

BgeeiENSG00000171291.
CleanExiHS_ZNF439.
ExpressionAtlasiQ8NDP4. baseline and differential.
GenevisibleiQ8NDP4. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 4 hits.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiZN439_HUMAN
AccessioniPrimary (citable) accession number: Q8NDP4
Secondary accession number(s): Q8IYZ7, Q96SU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 1, 2002
Last modified: March 15, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.