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Protein

Zinc finger protein 439

Gene

ZNF439

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri186 – 208C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 490C2H2-type 11PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 439
Gene namesi
Name:ZNF439
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171291.8
HGNCiHGNC:20873 ZNF439
neXtProtiNX_Q8NDP4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171291
PharmGKBiPA134886330

Polymorphism and mutation databases

BioMutaiZNF439
DMDMi30580628

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475881 – 499Zinc finger protein 439Add BLAST499

Proteomic databases

MaxQBiQ8NDP4
PaxDbiQ8NDP4
PeptideAtlasiQ8NDP4
PRIDEiQ8NDP4
ProteomicsDBi73047

PTM databases

iPTMnetiQ8NDP4
PhosphoSitePlusiQ8NDP4

Expressioni

Gene expression databases

BgeeiENSG00000171291
CleanExiHS_ZNF439
ExpressionAtlasiQ8NDP4 baseline and differential
GenevisibleiQ8NDP4 HS

Organism-specific databases

HPAiHPA047845

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124741, 16 interactors
IntActiQ8NDP4, 21 interactors
MINTiQ8NDP4
STRINGi9606.ENSP00000305077

Structurei

3D structure databases

ProteinModelPortaliQ8NDP4
SMRiQ8NDP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 101KRABPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri186 – 208C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 490C2H2-type 11PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119089
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8NDP4
KOiK09228
OMAiCHRHERS
OrthoDBiEOG091G02KC
PhylomeDBiQ8NDP4
TreeFamiTF338854

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequencei

Sequence statusi: Complete.

Q8NDP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLSPILLY TCEMFQDPVA FKDVAVNFTQ EEWALLDISQ KNLYREVMLE
60 70 80 90 100
TFWNLTSIGK KWKDQNIEYE YQNPRRNFRS VTEEKVNEIK EDSHCGETFT
110 120 130 140 150
PVPDDRLNFQ KKKASPEVKS CDSFVCEVGL GNSSSNMNIR GDTGHKACEC
160 170 180 190 200
QEYGPKPWKS QQPKKAFRYH PSLRTQERDH TGKKPYACKE CGKNIIYHSS
210 220 230 240 250
IQRHMVVHSG DGPYKCKFCG KAFHCLSLYL IHERTHTGEK PYECKQCGKS
260 270 280 290 300
FSYSATHRIH ERTHIGEKPY ECQECGKAFH SPRSCHRHER SHMGEKAYQC
310 320 330 340 350
KECGKAFMCP RYVRRHERTH SRKKLYECKQ CGKALSSLTS FQTHIRMHSG
360 370 380 390 400
ERPYECKTCG KGFYSAKSFQ RHEKTHSGEK PYKCKQCGKA FTRSGSFRYH
410 420 430 440 450
ERTHTGEKPY ECKQCGKAFR SAPNLQLHGR THTGEKPYQC KECGKAFRSA
460 470 480 490
SQLRIHRRIH TGEKPYECKK CGKAFRYVQN FRFHERTQTH KNALWRKTL
Length:499
Mass (Da):58,395
Last modified:October 1, 2002 - v1
Checksum:i483E3238E280F229
GO

Sequence cautioni

The sequence BAB55187 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0528276P → S. Corresponds to variant dbSNP:rs10421552Ensembl.1
Natural variantiVAR_024216427L → S1 PublicationCorresponds to variant dbSNP:rs10500209Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833935 mRNA Translation: CAD38790.1
AK027542 mRNA Translation: BAB55187.1 Different initiation.
BC032857 mRNA Translation: AAH32857.1
CCDSiCCDS12268.1
RefSeqiNP_001335653.1, NM_001348724.1
NP_001335654.1, NM_001348725.1
NP_689475.1, NM_152262.2
UniGeneiHs.528731

Genome annotation databases

EnsembliENST00000304030; ENSP00000305077; ENSG00000171291
GeneIDi90594
KEGGihsa:90594
UCSCiuc002msr.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN439_HUMAN
AccessioniPrimary (citable) accession number: Q8NDP4
Secondary accession number(s): Q8IYZ7, Q96SU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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