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Q8NDL9

- CBPC5_HUMAN

UniProt

Q8NDL9 - CBPC5_HUMAN

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Protein

Cytosolic carboxypeptidase-like protein 5

Gene

AGBL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi252 – 2521ZincBy similarity
Metal bindingi255 – 2551ZincBy similarity
Active sitei303 – 3031NucleophileBy similarity
Metal bindingi434 – 4341ZincBy similarity

GO - Molecular functioni

  1. metallocarboxypeptidase activity Source: UniProtKB
  2. tubulin binding Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein branching point deglutamylation Source: UniProtKB
  2. protein deglutamylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM14.025.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic carboxypeptidase-like protein 5 (EC:3.4.17.-)
Alternative name(s):
ATP/GTP-binding protein-like 5
Gene namesi
Name:AGBL5
Synonyms:CCP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:26147. AGBL5.

Subcellular locationi

Cytoplasmcytosol By similarity. Nucleus 1 Publication. Cytoplasmcytoskeletonspindle 1 Publication. Midbody 1 Publication
Note: Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis.By similarity1 Publication

GO - Cellular componenti

  1. cytoplasm Source: LIFEdb
  2. cytosol Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162375816.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 886886Cytosolic carboxypeptidase-like protein 5PRO_0000305921Add
BLAST

Proteomic databases

MaxQBiQ8NDL9.
PaxDbiQ8NDL9.
PRIDEiQ8NDL9.

PTM databases

PhosphoSiteiQ8NDL9.

Expressioni

Tissue specificityi

Expressed in brain.

Gene expression databases

BgeeiQ8NDL9.
CleanExiHS_AGBL5.
ExpressionAtlasiQ8NDL9. baseline and differential.
GenevestigatoriQ8NDL9.

Organism-specific databases

HPAiHPA030981.

Interactioni

Protein-protein interaction databases

BioGridi121935. 2 interactions.
IntActiQ8NDL9. 1 interaction.
MINTiMINT-4717805.

Structurei

3D structure databases

ProteinModelPortaliQ8NDL9.
SMRiQ8NDL9. Positions 241-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi540 – 5445Poly-Pro
Compositional biasi651 – 6544Poly-Ser

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Phylogenomic databases

eggNOGiCOG2866.
GeneTreeiENSGT00550000074405.
HOVERGENiHBG068187.
InParanoidiQ8NDL9.
OMAiPDTIPPK.
OrthoDBiEOG718KBS.
PhylomeDBiQ8NDL9.
TreeFamiTF324301.

Family and domain databases

InterProiIPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NDL9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELRCGGLLF SSRFDSGNLA HVEKVESLSS DGEGVGGGAS ALTSGIASSP
60 70 80 90 100
DYEFNVWTRP DCAETEFENG NRSWFYFSVR GGMPGKLIKI NIMNMNKQSK
110 120 130 140 150
LYSQGMAPFV RTLPTRPRWE RIRDRPTFEM TETQFVLSFV HRFVEGRGAT
160 170 180 190 200
TFFAFCYPFS YSDCQELLNQ LDQRFPENHP THSSPLDTIY YHRELLCYSL
210 220 230 240 250
DGLRVDLLTI TSCHGLREDR EPRLEQLFPD TSTPRPFRFA GKRIFFLSSR
260 270 280 290 300
VHPGETPSSF VFNGFLDFIL RPDDPRAQTL RRLFVFKLIP MLNPDGVVRG
310 320 330 340 350
HYRTDSRGVN LNRQYLKPDA VLHPAIYGAK AVLLYHHVHS RLNSQSSSEH
360 370 380 390 400
QPSSCLPPDA PVSDLEKANN LQNEAQCGHS ADRHNAEAWK QTEPAEQKLN
410 420 430 440 450
SVWIMPQQSA GLEESAPDTI PPKESGVAYY VDLHGHASKR GCFMYGNSFS
460 470 480 490 500
DESTQVENML YPKLISLNSA HFDFQGCNFS EKNMYARDRR DGQSKEGSGR
510 520 530 540 550
VAIYKASGII HSYTLECNYN TGRSVNSIPA ACHDNGRASP PPPPAFPSRY
560 570 580 590 600
TVELFEQVGR AMAIAALDMA ECNPWPRIVL SEHSSLTNLR AWMLKHVRNS
610 620 630 640 650
RGLSSTLNVG VNKKRGLRTP PKSHNGLPVS CSENTLSRAR SFSTGTSAGG
660 670 680 690 700
SSSSQQNSPQ MKNSPSFPFH GSRPAGLPGL GSSTQKVTHR VLGPVREPRS
710 720 730 740 750
QDRRRQQQPL NHRPAGSLAP SPAPTSSGPA SSHKLGSCLL PDSFNIPGSS
760 770 780 790 800
CSLLSSGDKP EAVMVIGKGL LGTGARMPCI KTRLQARPRL GRGSPPTRRG
810 820 830 840 850
MKGSSGPTSP TPRTRESSEL ELGSCSATPG LPQARPPRPR SAPAFSPISC
860 870 880
SLSDSPSWNC YSRGPLGQPE VCFVPKSPPL TVSPRV
Length:886
Mass (Da):97,534
Last modified:October 1, 2002 - v1
Checksum:i0948AD0F37B0725A
GO
Isoform 2 (identifier: Q8NDL9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     786-816: ARPRLGRGSPPTRRGMKGSSGPTSPTPRTRE → TCPRRVSARRGPGFPRLGPGWAGAHRRLAEG
     817-886: Missing.

Note: No experimental confirmation available.

Show »
Length:816
Mass (Da):90,252
Checksum:iFD717AAC3A12A1BE
GO
Isoform 3 (identifier: Q8NDL9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     697-717: EPRSQDRRRQQQPLNHRPAGS → GKPVWEPLQHVFGCLGHCWGK
     718-886: Missing.

Note: No experimental confirmation available.

Show »
Length:717
Mass (Da):80,016
Checksum:i67418CCF89A6734E
GO

Sequence cautioni

The sequence AAX93164.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAY14655.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAB15151.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 403GAS → CLL in AAI31499. (PubMed:15489334)Curated
Sequence conflicti94 – 941N → S in BAH13623. (PubMed:14702039)Curated
Sequence conflicti122 – 1221I → R in AAI31499. (PubMed:15489334)Curated
Sequence conflicti672 – 6721S → G in BAB15151. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti649 – 6491G → D.
Corresponds to variant rs35804461 [ dbSNP | Ensembl ].
VAR_035231

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei697 – 71721EPRSQ…RPAGS → GKPVWEPLQHVFGCLGHCWG K in isoform 3. 2 PublicationsVSP_028359Add
BLAST
Alternative sequencei718 – 886169Missing in isoform 3. 2 PublicationsVSP_028360Add
BLAST
Alternative sequencei786 – 81631ARPRL…PRTRE → TCPRRVSARRGPGFPRLGPG WAGAHRRLAEG in isoform 2. 1 PublicationVSP_028361Add
BLAST
Alternative sequencei817 – 88670Missing in isoform 2. 1 PublicationVSP_028362Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833844 mRNA. Translation: CAD38704.1.
AK302091 mRNA. Translation: BAH13623.1.
AC013403 Genomic DNA. Translation: AAX93164.1. Sequence problems.
AC013472 Genomic DNA. Translation: AAY14655.1. Sequence problems.
CH471053 Genomic DNA. Translation: EAX00649.1.
CH471053 Genomic DNA. Translation: EAX00651.1.
CH471053 Genomic DNA. Translation: EAX00652.1.
CH471053 Genomic DNA. Translation: EAX00653.1.
BC007415 mRNA. Translation: AAH07415.2.
BC018584 mRNA. No translation available.
BC131498 mRNA. Translation: AAI31499.1.
AK023398 mRNA. Translation: BAB14560.1.
AK025492 mRNA. Translation: BAB15151.1. Different initiation.
CCDSiCCDS1732.3. [Q8NDL9-1]
CCDS42665.1. [Q8NDL9-3]
RefSeqiNP_001030584.1. NM_001035507.2. [Q8NDL9-3]
NP_068603.4. NM_021831.5.
XP_006712121.1. XM_006712058.1. [Q8NDL9-2]
UniGeneiHs.138207.

Genome annotation databases

EnsembliENST00000323064; ENSP00000323681; ENSG00000084693. [Q8NDL9-3]
ENST00000360131; ENSP00000353249; ENSG00000084693. [Q8NDL9-1]
ENST00000487078; ENSP00000433830; ENSG00000084693. [Q8NDL9-2]
GeneIDi60509.
KEGGihsa:60509.
UCSCiuc002rid.3. human. [Q8NDL9-3]
uc002rie.3. human. [Q8NDL9-1]

Polymorphism databases

DMDMi74715354.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833844 mRNA. Translation: CAD38704.1 .
AK302091 mRNA. Translation: BAH13623.1 .
AC013403 Genomic DNA. Translation: AAX93164.1 . Sequence problems.
AC013472 Genomic DNA. Translation: AAY14655.1 . Sequence problems.
CH471053 Genomic DNA. Translation: EAX00649.1 .
CH471053 Genomic DNA. Translation: EAX00651.1 .
CH471053 Genomic DNA. Translation: EAX00652.1 .
CH471053 Genomic DNA. Translation: EAX00653.1 .
BC007415 mRNA. Translation: AAH07415.2 .
BC018584 mRNA. No translation available.
BC131498 mRNA. Translation: AAI31499.1 .
AK023398 mRNA. Translation: BAB14560.1 .
AK025492 mRNA. Translation: BAB15151.1 . Different initiation.
CCDSi CCDS1732.3. [Q8NDL9-1 ]
CCDS42665.1. [Q8NDL9-3 ]
RefSeqi NP_001030584.1. NM_001035507.2. [Q8NDL9-3 ]
NP_068603.4. NM_021831.5.
XP_006712121.1. XM_006712058.1. [Q8NDL9-2 ]
UniGenei Hs.138207.

3D structure databases

ProteinModelPortali Q8NDL9.
SMRi Q8NDL9. Positions 241-326.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121935. 2 interactions.
IntActi Q8NDL9. 1 interaction.
MINTi MINT-4717805.

Protein family/group databases

MEROPSi M14.025.

PTM databases

PhosphoSitei Q8NDL9.

Polymorphism databases

DMDMi 74715354.

Proteomic databases

MaxQBi Q8NDL9.
PaxDbi Q8NDL9.
PRIDEi Q8NDL9.

Protocols and materials databases

DNASUi 60509.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000323064 ; ENSP00000323681 ; ENSG00000084693 . [Q8NDL9-3 ]
ENST00000360131 ; ENSP00000353249 ; ENSG00000084693 . [Q8NDL9-1 ]
ENST00000487078 ; ENSP00000433830 ; ENSG00000084693 . [Q8NDL9-2 ]
GeneIDi 60509.
KEGGi hsa:60509.
UCSCi uc002rid.3. human. [Q8NDL9-3 ]
uc002rie.3. human. [Q8NDL9-1 ]

Organism-specific databases

CTDi 60509.
GeneCardsi GC02P027265.
HGNCi HGNC:26147. AGBL5.
HPAi HPA030981.
neXtProti NX_Q8NDL9.
PharmGKBi PA162375816.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2866.
GeneTreei ENSGT00550000074405.
HOVERGENi HBG068187.
InParanoidi Q8NDL9.
OMAi PDTIPPK.
OrthoDBi EOG718KBS.
PhylomeDBi Q8NDL9.
TreeFami TF324301.

Miscellaneous databases

ChiTaRSi AGBL5. human.
GenomeRNAii 60509.
NextBioi 65419.
PROi Q8NDL9.

Gene expression databases

Bgeei Q8NDL9.
CleanExi HS_AGBL5.
ExpressionAtlasi Q8NDL9. baseline and differential.
Genevestigatori Q8NDL9.

Family and domain databases

InterProi IPR000834. Peptidase_M14.
[Graphical view ]
Pfami PF00246. Peptidase_M14. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Ovary and Testis.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Skin.
  6. "Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs)."
    Rodriguez de la Vega Otazo M., Lorenzo J., Tort O., Aviles F.X., Bautista J.M.
    FASEB J. 27:424-431(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCBPC5_HUMAN
AccessioniPrimary (citable) accession number: Q8NDL9
Secondary accession number(s): A2VDI7
, B7WPG9, B7Z7I7, D6W548, Q53SW0, Q53SZ0, Q96IK8, Q9H6V0, Q9H8P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3