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Q8NDL9

- CBPC5_HUMAN

UniProt

Q8NDL9 - CBPC5_HUMAN

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Protein
Cytosolic carboxypeptidase-like protein 5
Gene
AGBL5, CCP5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/ CCP1, AGBL1/CCP4 and AGBL4/CCP6 By similarity.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi252 – 2521Zinc By similarity
Metal bindingi255 – 2551Zinc By similarity
Active sitei303 – 3031Nucleophile By similarity
Metal bindingi434 – 4341Zinc By similarity

GO - Molecular functioni

  1. metallocarboxypeptidase activity Source: UniProtKB
  2. tubulin binding Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein branching point deglutamylation Source: UniProtKB
  2. protein deglutamylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM14.025.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic carboxypeptidase-like protein 5 (EC:3.4.17.-)
Alternative name(s):
ATP/GTP-binding protein-like 5
Gene namesi
Name:AGBL5
Synonyms:CCP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:26147. AGBL5.

Subcellular locationi

Cytoplasmcytosol By similarity. Nucleus By similarity
Note: Mainly cytoplasmic. Slight accumulation in the nucleus is observed By similarity.

GO - Cellular componenti

  1. cytoplasm Source: LIFEdb
  2. cytosol Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162375816.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 886886Cytosolic carboxypeptidase-like protein 5
PRO_0000305921Add
BLAST

Proteomic databases

PaxDbiQ8NDL9.
PRIDEiQ8NDL9.

PTM databases

PhosphoSiteiQ8NDL9.

Expressioni

Tissue specificityi

Expressed in brain.

Gene expression databases

ArrayExpressiQ8NDL9.
BgeeiQ8NDL9.
CleanExiHS_AGBL5.
GenevestigatoriQ8NDL9.

Organism-specific databases

HPAiHPA030981.

Interactioni

Protein-protein interaction databases

BioGridi121935. 1 interaction.
IntActiQ8NDL9. 1 interaction.
MINTiMINT-4717805.

Structurei

3D structure databases

ProteinModelPortaliQ8NDL9.
SMRiQ8NDL9. Positions 241-326.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi540 – 5445Poly-Pro
Compositional biasi651 – 6544Poly-Ser

Sequence similaritiesi

Belongs to the peptidase M14 family.

Phylogenomic databases

eggNOGiCOG2866.
HOVERGENiHBG068187.
InParanoidiQ8NDL9.
OMAiPDTIPPK.
OrthoDBiEOG718KBS.
PhylomeDBiQ8NDL9.
TreeFamiTF324301.

Family and domain databases

InterProiIPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NDL9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MELRCGGLLF SSRFDSGNLA HVEKVESLSS DGEGVGGGAS ALTSGIASSP    50
DYEFNVWTRP DCAETEFENG NRSWFYFSVR GGMPGKLIKI NIMNMNKQSK 100
LYSQGMAPFV RTLPTRPRWE RIRDRPTFEM TETQFVLSFV HRFVEGRGAT 150
TFFAFCYPFS YSDCQELLNQ LDQRFPENHP THSSPLDTIY YHRELLCYSL 200
DGLRVDLLTI TSCHGLREDR EPRLEQLFPD TSTPRPFRFA GKRIFFLSSR 250
VHPGETPSSF VFNGFLDFIL RPDDPRAQTL RRLFVFKLIP MLNPDGVVRG 300
HYRTDSRGVN LNRQYLKPDA VLHPAIYGAK AVLLYHHVHS RLNSQSSSEH 350
QPSSCLPPDA PVSDLEKANN LQNEAQCGHS ADRHNAEAWK QTEPAEQKLN 400
SVWIMPQQSA GLEESAPDTI PPKESGVAYY VDLHGHASKR GCFMYGNSFS 450
DESTQVENML YPKLISLNSA HFDFQGCNFS EKNMYARDRR DGQSKEGSGR 500
VAIYKASGII HSYTLECNYN TGRSVNSIPA ACHDNGRASP PPPPAFPSRY 550
TVELFEQVGR AMAIAALDMA ECNPWPRIVL SEHSSLTNLR AWMLKHVRNS 600
RGLSSTLNVG VNKKRGLRTP PKSHNGLPVS CSENTLSRAR SFSTGTSAGG 650
SSSSQQNSPQ MKNSPSFPFH GSRPAGLPGL GSSTQKVTHR VLGPVREPRS 700
QDRRRQQQPL NHRPAGSLAP SPAPTSSGPA SSHKLGSCLL PDSFNIPGSS 750
CSLLSSGDKP EAVMVIGKGL LGTGARMPCI KTRLQARPRL GRGSPPTRRG 800
MKGSSGPTSP TPRTRESSEL ELGSCSATPG LPQARPPRPR SAPAFSPISC 850
SLSDSPSWNC YSRGPLGQPE VCFVPKSPPL TVSPRV 886
Length:886
Mass (Da):97,534
Last modified:October 1, 2002 - v1
Checksum:i0948AD0F37B0725A
GO
Isoform 2 (identifier: Q8NDL9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     786-816: ARPRLGRGSPPTRRGMKGSSGPTSPTPRTRE → TCPRRVSARRGPGFPRLGPGWAGAHRRLAEG
     817-886: Missing.

Note: No experimental confirmation available.

Show »
Length:816
Mass (Da):90,252
Checksum:iFD717AAC3A12A1BE
GO
Isoform 3 (identifier: Q8NDL9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     697-717: EPRSQDRRRQQQPLNHRPAGS → GKPVWEPLQHVFGCLGHCWGK
     718-886: Missing.

Note: No experimental confirmation available.

Show »
Length:717
Mass (Da):80,016
Checksum:i67418CCF89A6734E
GO

Sequence cautioni

The sequence BAB15151.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAX93164.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence AAY14655.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti649 – 6491G → D.
Corresponds to variant rs35804461 [ dbSNP | Ensembl ].
VAR_035231

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei697 – 71721EPRSQ…RPAGS → GKPVWEPLQHVFGCLGHCWG K in isoform 3.
VSP_028359Add
BLAST
Alternative sequencei718 – 886169Missing in isoform 3.
VSP_028360Add
BLAST
Alternative sequencei786 – 81631ARPRL…PRTRE → TCPRRVSARRGPGFPRLGPG WAGAHRRLAEG in isoform 2.
VSP_028361Add
BLAST
Alternative sequencei817 – 88670Missing in isoform 2.
VSP_028362Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 403GAS → CLL in AAI31499. 1 Publication
Sequence conflicti94 – 941N → S in BAH13623. 1 Publication
Sequence conflicti122 – 1221I → R in AAI31499. 1 Publication
Sequence conflicti672 – 6721S → G in BAB15151. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL833844 mRNA. Translation: CAD38704.1.
AK302091 mRNA. Translation: BAH13623.1.
AC013403 Genomic DNA. Translation: AAX93164.1. Sequence problems.
AC013472 Genomic DNA. Translation: AAY14655.1. Sequence problems.
CH471053 Genomic DNA. Translation: EAX00649.1.
CH471053 Genomic DNA. Translation: EAX00651.1.
CH471053 Genomic DNA. Translation: EAX00652.1.
CH471053 Genomic DNA. Translation: EAX00653.1.
BC007415 mRNA. Translation: AAH07415.2.
BC018584 mRNA. No translation available.
BC131498 mRNA. Translation: AAI31499.1.
AK023398 mRNA. Translation: BAB14560.1.
AK025492 mRNA. Translation: BAB15151.1. Different initiation.
CCDSiCCDS1732.3. [Q8NDL9-1]
CCDS42665.1. [Q8NDL9-3]
RefSeqiNP_001030584.1. NM_001035507.2. [Q8NDL9-3]
NP_068603.4. NM_021831.5.
XP_006712121.1. XM_006712058.1. [Q8NDL9-2]
UniGeneiHs.138207.

Genome annotation databases

EnsembliENST00000323064; ENSP00000323681; ENSG00000084693. [Q8NDL9-3]
ENST00000360131; ENSP00000353249; ENSG00000084693. [Q8NDL9-1]
ENST00000487078; ENSP00000433830; ENSG00000084693. [Q8NDL9-2]
GeneIDi60509.
KEGGihsa:60509.
UCSCiuc002rid.3. human. [Q8NDL9-3]
uc002rie.3. human. [Q8NDL9-1]

Polymorphism databases

DMDMi74715354.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL833844 mRNA. Translation: CAD38704.1 .
AK302091 mRNA. Translation: BAH13623.1 .
AC013403 Genomic DNA. Translation: AAX93164.1 . Sequence problems.
AC013472 Genomic DNA. Translation: AAY14655.1 . Sequence problems.
CH471053 Genomic DNA. Translation: EAX00649.1 .
CH471053 Genomic DNA. Translation: EAX00651.1 .
CH471053 Genomic DNA. Translation: EAX00652.1 .
CH471053 Genomic DNA. Translation: EAX00653.1 .
BC007415 mRNA. Translation: AAH07415.2 .
BC018584 mRNA. No translation available.
BC131498 mRNA. Translation: AAI31499.1 .
AK023398 mRNA. Translation: BAB14560.1 .
AK025492 mRNA. Translation: BAB15151.1 . Different initiation.
CCDSi CCDS1732.3. [Q8NDL9-1 ]
CCDS42665.1. [Q8NDL9-3 ]
RefSeqi NP_001030584.1. NM_001035507.2. [Q8NDL9-3 ]
NP_068603.4. NM_021831.5.
XP_006712121.1. XM_006712058.1. [Q8NDL9-2 ]
UniGenei Hs.138207.

3D structure databases

ProteinModelPortali Q8NDL9.
SMRi Q8NDL9. Positions 241-326.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121935. 1 interaction.
IntActi Q8NDL9. 1 interaction.
MINTi MINT-4717805.

Protein family/group databases

MEROPSi M14.025.

PTM databases

PhosphoSitei Q8NDL9.

Polymorphism databases

DMDMi 74715354.

Proteomic databases

PaxDbi Q8NDL9.
PRIDEi Q8NDL9.

Protocols and materials databases

DNASUi 60509.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000323064 ; ENSP00000323681 ; ENSG00000084693 . [Q8NDL9-3 ]
ENST00000360131 ; ENSP00000353249 ; ENSG00000084693 . [Q8NDL9-1 ]
ENST00000487078 ; ENSP00000433830 ; ENSG00000084693 . [Q8NDL9-2 ]
GeneIDi 60509.
KEGGi hsa:60509.
UCSCi uc002rid.3. human. [Q8NDL9-3 ]
uc002rie.3. human. [Q8NDL9-1 ]

Organism-specific databases

CTDi 60509.
GeneCardsi GC02P027265.
HGNCi HGNC:26147. AGBL5.
HPAi HPA030981.
neXtProti NX_Q8NDL9.
PharmGKBi PA162375816.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2866.
HOVERGENi HBG068187.
InParanoidi Q8NDL9.
OMAi PDTIPPK.
OrthoDBi EOG718KBS.
PhylomeDBi Q8NDL9.
TreeFami TF324301.

Miscellaneous databases

ChiTaRSi AGBL5. human.
GenomeRNAii 60509.
NextBioi 65419.
PROi Q8NDL9.

Gene expression databases

ArrayExpressi Q8NDL9.
Bgeei Q8NDL9.
CleanExi HS_AGBL5.
Genevestigatori Q8NDL9.

Family and domain databases

InterProi IPR000834. Peptidase_M14.
[Graphical view ]
Pfami PF00246. Peptidase_M14. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Ovary and Testis.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Skin.

Entry informationi

Entry nameiCBPC5_HUMAN
AccessioniPrimary (citable) accession number: Q8NDL9
Secondary accession number(s): A2VDI7
, B7WPG9, B7Z7I7, D6W548, Q53SW0, Q53SZ0, Q96IK8, Q9H6V0, Q9H8P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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