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Q8NDL9

- CBPC5_HUMAN

UniProt

Q8NDL9 - CBPC5_HUMAN

Protein

Cytosolic carboxypeptidase-like protein 5

Gene

AGBL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/ CCP1, AGBL1/CCP4 and AGBL4/CCP6 By similarity.By similarity

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi252 – 2521ZincBy similarity
    Metal bindingi255 – 2551ZincBy similarity
    Active sitei303 – 3031NucleophileBy similarity
    Metal bindingi434 – 4341ZincBy similarity

    GO - Molecular functioni

    1. metallocarboxypeptidase activity Source: UniProtKB
    2. tubulin binding Source: UniProtKB
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein branching point deglutamylation Source: UniProtKB
    2. protein deglutamylation Source: UniProtKB

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM14.025.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytosolic carboxypeptidase-like protein 5 (EC:3.4.17.-)
    Alternative name(s):
    ATP/GTP-binding protein-like 5
    Gene namesi
    Name:AGBL5
    Synonyms:CCP5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:26147. AGBL5.

    Subcellular locationi

    Cytoplasmcytosol By similarity. Nucleus By similarity
    Note: Mainly cytoplasmic. Slight accumulation in the nucleus is observed By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: LIFEdb
    2. cytosol Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162375816.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 886886Cytosolic carboxypeptidase-like protein 5PRO_0000305921Add
    BLAST

    Proteomic databases

    PaxDbiQ8NDL9.
    PRIDEiQ8NDL9.

    PTM databases

    PhosphoSiteiQ8NDL9.

    Expressioni

    Tissue specificityi

    Expressed in brain.

    Gene expression databases

    ArrayExpressiQ8NDL9.
    BgeeiQ8NDL9.
    CleanExiHS_AGBL5.
    GenevestigatoriQ8NDL9.

    Organism-specific databases

    HPAiHPA030981.

    Interactioni

    Protein-protein interaction databases

    BioGridi121935. 1 interaction.
    IntActiQ8NDL9. 1 interaction.
    MINTiMINT-4717805.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NDL9.
    SMRiQ8NDL9. Positions 241-326.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi540 – 5445Poly-Pro
    Compositional biasi651 – 6544Poly-Ser

    Sequence similaritiesi

    Belongs to the peptidase M14 family.Curated

    Phylogenomic databases

    eggNOGiCOG2866.
    HOVERGENiHBG068187.
    InParanoidiQ8NDL9.
    OMAiPDTIPPK.
    OrthoDBiEOG718KBS.
    PhylomeDBiQ8NDL9.
    TreeFamiTF324301.

    Family and domain databases

    InterProiIPR000834. Peptidase_M14.
    [Graphical view]
    PfamiPF00246. Peptidase_M14. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NDL9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MELRCGGLLF SSRFDSGNLA HVEKVESLSS DGEGVGGGAS ALTSGIASSP    50
    DYEFNVWTRP DCAETEFENG NRSWFYFSVR GGMPGKLIKI NIMNMNKQSK 100
    LYSQGMAPFV RTLPTRPRWE RIRDRPTFEM TETQFVLSFV HRFVEGRGAT 150
    TFFAFCYPFS YSDCQELLNQ LDQRFPENHP THSSPLDTIY YHRELLCYSL 200
    DGLRVDLLTI TSCHGLREDR EPRLEQLFPD TSTPRPFRFA GKRIFFLSSR 250
    VHPGETPSSF VFNGFLDFIL RPDDPRAQTL RRLFVFKLIP MLNPDGVVRG 300
    HYRTDSRGVN LNRQYLKPDA VLHPAIYGAK AVLLYHHVHS RLNSQSSSEH 350
    QPSSCLPPDA PVSDLEKANN LQNEAQCGHS ADRHNAEAWK QTEPAEQKLN 400
    SVWIMPQQSA GLEESAPDTI PPKESGVAYY VDLHGHASKR GCFMYGNSFS 450
    DESTQVENML YPKLISLNSA HFDFQGCNFS EKNMYARDRR DGQSKEGSGR 500
    VAIYKASGII HSYTLECNYN TGRSVNSIPA ACHDNGRASP PPPPAFPSRY 550
    TVELFEQVGR AMAIAALDMA ECNPWPRIVL SEHSSLTNLR AWMLKHVRNS 600
    RGLSSTLNVG VNKKRGLRTP PKSHNGLPVS CSENTLSRAR SFSTGTSAGG 650
    SSSSQQNSPQ MKNSPSFPFH GSRPAGLPGL GSSTQKVTHR VLGPVREPRS 700
    QDRRRQQQPL NHRPAGSLAP SPAPTSSGPA SSHKLGSCLL PDSFNIPGSS 750
    CSLLSSGDKP EAVMVIGKGL LGTGARMPCI KTRLQARPRL GRGSPPTRRG 800
    MKGSSGPTSP TPRTRESSEL ELGSCSATPG LPQARPPRPR SAPAFSPISC 850
    SLSDSPSWNC YSRGPLGQPE VCFVPKSPPL TVSPRV 886
    Length:886
    Mass (Da):97,534
    Last modified:October 1, 2002 - v1
    Checksum:i0948AD0F37B0725A
    GO
    Isoform 2 (identifier: Q8NDL9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         786-816: ARPRLGRGSPPTRRGMKGSSGPTSPTPRTRE → TCPRRVSARRGPGFPRLGPGWAGAHRRLAEG
         817-886: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:816
    Mass (Da):90,252
    Checksum:iFD717AAC3A12A1BE
    GO
    Isoform 3 (identifier: Q8NDL9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         697-717: EPRSQDRRRQQQPLNHRPAGS → GKPVWEPLQHVFGCLGHCWGK
         718-886: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:717
    Mass (Da):80,016
    Checksum:i67418CCF89A6734E
    GO

    Sequence cautioni

    The sequence BAB15151.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAX93164.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence AAY14655.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti38 – 403GAS → CLL in AAI31499. (PubMed:15489334)Curated
    Sequence conflicti94 – 941N → S in BAH13623. (PubMed:14702039)Curated
    Sequence conflicti122 – 1221I → R in AAI31499. (PubMed:15489334)Curated
    Sequence conflicti672 – 6721S → G in BAB15151. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti649 – 6491G → D.
    Corresponds to variant rs35804461 [ dbSNP | Ensembl ].
    VAR_035231

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei697 – 71721EPRSQ…RPAGS → GKPVWEPLQHVFGCLGHCWG K in isoform 3. 2 PublicationsVSP_028359Add
    BLAST
    Alternative sequencei718 – 886169Missing in isoform 3. 2 PublicationsVSP_028360Add
    BLAST
    Alternative sequencei786 – 81631ARPRL…PRTRE → TCPRRVSARRGPGFPRLGPG WAGAHRRLAEG in isoform 2. 1 PublicationVSP_028361Add
    BLAST
    Alternative sequencei817 – 88670Missing in isoform 2. 1 PublicationVSP_028362Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL833844 mRNA. Translation: CAD38704.1.
    AK302091 mRNA. Translation: BAH13623.1.
    AC013403 Genomic DNA. Translation: AAX93164.1. Sequence problems.
    AC013472 Genomic DNA. Translation: AAY14655.1. Sequence problems.
    CH471053 Genomic DNA. Translation: EAX00649.1.
    CH471053 Genomic DNA. Translation: EAX00651.1.
    CH471053 Genomic DNA. Translation: EAX00652.1.
    CH471053 Genomic DNA. Translation: EAX00653.1.
    BC007415 mRNA. Translation: AAH07415.2.
    BC018584 mRNA. No translation available.
    BC131498 mRNA. Translation: AAI31499.1.
    AK023398 mRNA. Translation: BAB14560.1.
    AK025492 mRNA. Translation: BAB15151.1. Different initiation.
    CCDSiCCDS1732.3. [Q8NDL9-1]
    CCDS42665.1. [Q8NDL9-3]
    RefSeqiNP_001030584.1. NM_001035507.2. [Q8NDL9-3]
    NP_068603.4. NM_021831.5.
    XP_006712121.1. XM_006712058.1. [Q8NDL9-2]
    UniGeneiHs.138207.

    Genome annotation databases

    EnsembliENST00000323064; ENSP00000323681; ENSG00000084693. [Q8NDL9-3]
    ENST00000360131; ENSP00000353249; ENSG00000084693. [Q8NDL9-1]
    ENST00000487078; ENSP00000433830; ENSG00000084693. [Q8NDL9-2]
    GeneIDi60509.
    KEGGihsa:60509.
    UCSCiuc002rid.3. human. [Q8NDL9-3]
    uc002rie.3. human. [Q8NDL9-1]

    Polymorphism databases

    DMDMi74715354.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL833844 mRNA. Translation: CAD38704.1 .
    AK302091 mRNA. Translation: BAH13623.1 .
    AC013403 Genomic DNA. Translation: AAX93164.1 . Sequence problems.
    AC013472 Genomic DNA. Translation: AAY14655.1 . Sequence problems.
    CH471053 Genomic DNA. Translation: EAX00649.1 .
    CH471053 Genomic DNA. Translation: EAX00651.1 .
    CH471053 Genomic DNA. Translation: EAX00652.1 .
    CH471053 Genomic DNA. Translation: EAX00653.1 .
    BC007415 mRNA. Translation: AAH07415.2 .
    BC018584 mRNA. No translation available.
    BC131498 mRNA. Translation: AAI31499.1 .
    AK023398 mRNA. Translation: BAB14560.1 .
    AK025492 mRNA. Translation: BAB15151.1 . Different initiation.
    CCDSi CCDS1732.3. [Q8NDL9-1 ]
    CCDS42665.1. [Q8NDL9-3 ]
    RefSeqi NP_001030584.1. NM_001035507.2. [Q8NDL9-3 ]
    NP_068603.4. NM_021831.5.
    XP_006712121.1. XM_006712058.1. [Q8NDL9-2 ]
    UniGenei Hs.138207.

    3D structure databases

    ProteinModelPortali Q8NDL9.
    SMRi Q8NDL9. Positions 241-326.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121935. 1 interaction.
    IntActi Q8NDL9. 1 interaction.
    MINTi MINT-4717805.

    Protein family/group databases

    MEROPSi M14.025.

    PTM databases

    PhosphoSitei Q8NDL9.

    Polymorphism databases

    DMDMi 74715354.

    Proteomic databases

    PaxDbi Q8NDL9.
    PRIDEi Q8NDL9.

    Protocols and materials databases

    DNASUi 60509.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000323064 ; ENSP00000323681 ; ENSG00000084693 . [Q8NDL9-3 ]
    ENST00000360131 ; ENSP00000353249 ; ENSG00000084693 . [Q8NDL9-1 ]
    ENST00000487078 ; ENSP00000433830 ; ENSG00000084693 . [Q8NDL9-2 ]
    GeneIDi 60509.
    KEGGi hsa:60509.
    UCSCi uc002rid.3. human. [Q8NDL9-3 ]
    uc002rie.3. human. [Q8NDL9-1 ]

    Organism-specific databases

    CTDi 60509.
    GeneCardsi GC02P027265.
    HGNCi HGNC:26147. AGBL5.
    HPAi HPA030981.
    neXtProti NX_Q8NDL9.
    PharmGKBi PA162375816.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2866.
    HOVERGENi HBG068187.
    InParanoidi Q8NDL9.
    OMAi PDTIPPK.
    OrthoDBi EOG718KBS.
    PhylomeDBi Q8NDL9.
    TreeFami TF324301.

    Miscellaneous databases

    ChiTaRSi AGBL5. human.
    GenomeRNAii 60509.
    NextBioi 65419.
    PROi Q8NDL9.

    Gene expression databases

    ArrayExpressi Q8NDL9.
    Bgeei Q8NDL9.
    CleanExi HS_AGBL5.
    Genevestigatori Q8NDL9.

    Family and domain databases

    InterProi IPR000834. Peptidase_M14.
    [Graphical view ]
    Pfami PF00246. Peptidase_M14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Ovary and Testis.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Skin.

    Entry informationi

    Entry nameiCBPC5_HUMAN
    AccessioniPrimary (citable) accession number: Q8NDL9
    Secondary accession number(s): A2VDI7
    , B7WPG9, B7Z7I7, D6W548, Q53SW0, Q53SZ0, Q96IK8, Q9H6V0, Q9H8P8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3