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Q8NDL9 (CBPC5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytosolic carboxypeptidase-like protein 5

EC=3.4.17.-
Alternative name(s):
ATP/GTP-binding protein-like 5
Gene names
Name:AGBL5
Synonyms:CCP5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length886 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/ CCP1, AGBL1/CCP4 and AGBL4/CCP6 By similarity.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Cytoplasmcytosol By similarity. Nucleus By similarity. Note: Mainly cytoplasmic. Slight accumulation in the nucleus is observed By similarity.

Tissue specificity

Expressed in brain.

Sequence similarities

Belongs to the peptidase M14 family.

Sequence caution

The sequence AAX93164.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AAY14655.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAB15151.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NDL9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NDL9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     786-816: ARPRLGRGSPPTRRGMKGSSGPTSPTPRTRE → TCPRRVSARRGPGFPRLGPGWAGAHRRLAEG
     817-886: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8NDL9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     697-717: EPRSQDRRRQQQPLNHRPAGS → GKPVWEPLQHVFGCLGHCWGK
     718-886: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 886886Cytosolic carboxypeptidase-like protein 5
PRO_0000305921

Regions

Compositional bias540 – 5445Poly-Pro
Compositional bias651 – 6544Poly-Ser

Sites

Active site3031Nucleophile By similarity
Metal binding2521Zinc By similarity
Metal binding2551Zinc By similarity
Metal binding4341Zinc By similarity

Natural variations

Alternative sequence697 – 71721EPRSQ…RPAGS → GKPVWEPLQHVFGCLGHCWG K in isoform 3.
VSP_028359
Alternative sequence718 – 886169Missing in isoform 3.
VSP_028360
Alternative sequence786 – 81631ARPRL…PRTRE → TCPRRVSARRGPGFPRLGPG WAGAHRRLAEG in isoform 2.
VSP_028361
Alternative sequence817 – 88670Missing in isoform 2.
VSP_028362
Natural variant6491G → D.
Corresponds to variant rs35804461 [ dbSNP | Ensembl ].
VAR_035231

Experimental info

Sequence conflict38 – 403GAS → CLL in AAI31499. Ref.5
Sequence conflict941N → S in BAH13623. Ref.2
Sequence conflict1221I → R in AAI31499. Ref.5
Sequence conflict6721S → G in BAB15151. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 0948AD0F37B0725A

FASTA88697,534
        10         20         30         40         50         60 
MELRCGGLLF SSRFDSGNLA HVEKVESLSS DGEGVGGGAS ALTSGIASSP DYEFNVWTRP 

        70         80         90        100        110        120 
DCAETEFENG NRSWFYFSVR GGMPGKLIKI NIMNMNKQSK LYSQGMAPFV RTLPTRPRWE 

       130        140        150        160        170        180 
RIRDRPTFEM TETQFVLSFV HRFVEGRGAT TFFAFCYPFS YSDCQELLNQ LDQRFPENHP 

       190        200        210        220        230        240 
THSSPLDTIY YHRELLCYSL DGLRVDLLTI TSCHGLREDR EPRLEQLFPD TSTPRPFRFA 

       250        260        270        280        290        300 
GKRIFFLSSR VHPGETPSSF VFNGFLDFIL RPDDPRAQTL RRLFVFKLIP MLNPDGVVRG 

       310        320        330        340        350        360 
HYRTDSRGVN LNRQYLKPDA VLHPAIYGAK AVLLYHHVHS RLNSQSSSEH QPSSCLPPDA 

       370        380        390        400        410        420 
PVSDLEKANN LQNEAQCGHS ADRHNAEAWK QTEPAEQKLN SVWIMPQQSA GLEESAPDTI 

       430        440        450        460        470        480 
PPKESGVAYY VDLHGHASKR GCFMYGNSFS DESTQVENML YPKLISLNSA HFDFQGCNFS 

       490        500        510        520        530        540 
EKNMYARDRR DGQSKEGSGR VAIYKASGII HSYTLECNYN TGRSVNSIPA ACHDNGRASP 

       550        560        570        580        590        600 
PPPPAFPSRY TVELFEQVGR AMAIAALDMA ECNPWPRIVL SEHSSLTNLR AWMLKHVRNS 

       610        620        630        640        650        660 
RGLSSTLNVG VNKKRGLRTP PKSHNGLPVS CSENTLSRAR SFSTGTSAGG SSSSQQNSPQ 

       670        680        690        700        710        720 
MKNSPSFPFH GSRPAGLPGL GSSTQKVTHR VLGPVREPRS QDRRRQQQPL NHRPAGSLAP 

       730        740        750        760        770        780 
SPAPTSSGPA SSHKLGSCLL PDSFNIPGSS CSLLSSGDKP EAVMVIGKGL LGTGARMPCI 

       790        800        810        820        830        840 
KTRLQARPRL GRGSPPTRRG MKGSSGPTSP TPRTRESSEL ELGSCSATPG LPQARPPRPR 

       850        860        870        880 
SAPAFSPISC SLSDSPSWNC YSRGPLGQPE VCFVPKSPPL TVSPRV 

« Hide

Isoform 2 [UniParc].

Checksum: FD717AAC3A12A1BE
Show »

FASTA81690,252
Isoform 3 [UniParc].

Checksum: 67418CCF89A6734E
Show »

FASTA71780,016

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Ovary and Testis.
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL833844 mRNA. Translation: CAD38704.1.
AK302091 mRNA. Translation: BAH13623.1.
AC013403 Genomic DNA. Translation: AAX93164.1. Sequence problems.
AC013472 Genomic DNA. Translation: AAY14655.1. Sequence problems.
CH471053 Genomic DNA. Translation: EAX00649.1.
CH471053 Genomic DNA. Translation: EAX00651.1.
CH471053 Genomic DNA. Translation: EAX00652.1.
CH471053 Genomic DNA. Translation: EAX00653.1.
BC007415 mRNA. Translation: AAH07415.2.
BC018584 mRNA. No translation available.
BC131498 mRNA. Translation: AAI31499.1.
AK023398 mRNA. Translation: BAB14560.1.
AK025492 mRNA. Translation: BAB15151.1. Different initiation.
CCDSCCDS1732.3. [Q8NDL9-1]
CCDS42665.1. [Q8NDL9-3]
RefSeqNP_001030584.1. NM_001035507.2. [Q8NDL9-3]
NP_068603.4. NM_021831.5.
XP_006712121.1. XM_006712058.1. [Q8NDL9-2]
UniGeneHs.138207.

3D structure databases

ProteinModelPortalQ8NDL9.
SMRQ8NDL9. Positions 241-326.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121935. 1 interaction.
IntActQ8NDL9. 1 interaction.
MINTMINT-4717805.

Protein family/group databases

MEROPSM14.025.

PTM databases

PhosphoSiteQ8NDL9.

Polymorphism databases

DMDM74715354.

Proteomic databases

PaxDbQ8NDL9.
PRIDEQ8NDL9.

Protocols and materials databases

DNASU60509.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000323064; ENSP00000323681; ENSG00000084693. [Q8NDL9-3]
ENST00000360131; ENSP00000353249; ENSG00000084693. [Q8NDL9-1]
ENST00000487078; ENSP00000433830; ENSG00000084693. [Q8NDL9-2]
GeneID60509.
KEGGhsa:60509.
UCSCuc002rid.3. human. [Q8NDL9-3]
uc002rie.3. human. [Q8NDL9-1]

Organism-specific databases

CTD60509.
GeneCardsGC02P027265.
HGNCHGNC:26147. AGBL5.
HPAHPA030981.
neXtProtNX_Q8NDL9.
PharmGKBPA162375816.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2866.
HOVERGENHBG068187.
InParanoidQ8NDL9.
OMAPDTIPPK.
OrthoDBEOG718KBS.
PhylomeDBQ8NDL9.
TreeFamTF324301.

Gene expression databases

ArrayExpressQ8NDL9.
BgeeQ8NDL9.
CleanExHS_AGBL5.
GenevestigatorQ8NDL9.

Family and domain databases

InterProIPR000834. Peptidase_M14.
[Graphical view]
PfamPF00246. Peptidase_M14. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAGBL5. human.
GenomeRNAi60509.
NextBio65419.
PROQ8NDL9.

Entry information

Entry nameCBPC5_HUMAN
AccessionPrimary (citable) accession number: Q8NDL9
Secondary accession number(s): A2VDI7 expand/collapse secondary AC list , B7WPG9, B7Z7I7, D6W548, Q53SW0, Q53SZ0, Q96IK8, Q9H6V0, Q9H8P8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM