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Protein

Islet cell autoantigen 1-like protein

Gene

ICA1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Islet cell autoantigen 1-like protein
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 14 protein
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein
Gene namesi
Name:ICA1L
Synonyms:ALS2CR14, ALS2CR15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163596.16.
HGNCiHGNC:14442. ICA1L.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi130026.
OpenTargetsiENSG00000163596.
PharmGKBiPA24738.

Polymorphism and mutation databases

BioMutaiICA1L.
DMDMi74751222.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000761751 – 482Islet cell autoantigen 1-like proteinAdd BLAST482

Proteomic databases

EPDiQ8NDH6.
PaxDbiQ8NDH6.
PeptideAtlasiQ8NDH6.
PRIDEiQ8NDH6.

PTM databases

iPTMnetiQ8NDH6.
PhosphoSitePlusiQ8NDH6.

Expressioni

Gene expression databases

BgeeiENSG00000163596.
CleanExiHS_ICA1L.
ExpressionAtlasiQ8NDH6. baseline and differential.
GenevisibleiQ8NDH6. HS.

Organism-specific databases

HPAiHPA042507.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KIFC3Q9BVG83EBI-10269733,EBI-2125614

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126218. 2 interactors.
IntActiQ8NDH6. 2 interactors.
STRINGi9606.ENSP00000351047.

Structurei

3D structure databases

ProteinModelPortaliQ8NDH6.
SMRiQ8NDH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 247AHPROSITE-ProRule annotationAdd BLAST204

Phylogenomic databases

eggNOGiKOG3891. Eukaryota.
ENOG410YJKW. LUCA.
GeneTreeiENSGT00390000005530.
HOVERGENiHBG061005.
InParanoidiQ8NDH6.
KOiK19864.
OMAiFDLGLHA.
OrthoDBiEOG091G0BDC.
PhylomeDBiQ8NDH6.
TreeFamiTF317186.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiView protein in InterPro
IPR027267. AH/BAR_dom_sf.
IPR010504. AH_dom.
IPR024114. Islet_autoAg_Ica1/Ica1-like.
IPR006723. Islet_autoAg_Ica1_C.
PANTHERiPTHR10164. PTHR10164. 1 hit.
PfamiView protein in Pfam
PF06456. Arfaptin. 1 hit.
PF04629. ICA69. 1 hit.
SMARTiView protein in SMART
SM01015. Arfaptin. 1 hit.
SM01237. ICA69. 1 hit.
SUPFAMiSSF103657. SSF103657. 1 hit.
PROSITEiView protein in PROSITE
PS50870. AH. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NDH6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSFGQPRPE DNQSVVRRMQ KKYWKTKQVF IKATGKKEDE HLVASDAELD
60 70 80 90 100
AKLEVFHSVQ ETCTELLKII EKYQLRLNVI SEEENELGLF LKFQAERDAT
110 120 130 140 150
QAGKMMDATG KALCSSAKQR LALCTPLSRL KQEVATFSQR AVSDTLMTIN
160 170 180 190 200
RMEQARTEYR GALLWMKDVS QELDPDTLKQ MEKFRKVQMQ VRNSKASFDK
210 220 230 240 250
LKMDVCQKVD LLGASRCNML SHSLTTYQRT LLGFWKKTAR MMSQIHEACI
260 270 280 290 300
GFHPYDFVAL KQLQDTPSKI SEDNKDEQIG GFLTEQLNKL VLSDEEASFE
310 320 330 340 350
SEQANKDHNE KHSQMREFGA PQFSNSENVA KDLPVDSLEG EDFEKEFSFL
360 370 380 390 400
NNLLSSGSSS TSEFTQECQT AFGSPSASLT SQEPSMGSEP LAHSSRFLPS
410 420 430 440 450
QLFDLGFHVA GAFNNWVSQE ESELCLSHTD NQPVPSQSPK KLTRSPNNGN
460 470 480
QDMSAWFNLF ADLDPLSNPD AIGHSDDELL NA
Length:482
Mass (Da):54,407
Last modified:October 1, 2002 - v1
Checksum:iCB54E9658DA12DCC
GO
Isoform 2 (identifier: Q8NDH6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-482: Missing.

Note: No experimental confirmation available.
Show »
Length:187
Mass (Da):21,581
Checksum:i26EE3DD4A502225E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242M → V in BAB71062 (PubMed:14702039).Curated1
Sequence conflicti294D → N in BAB69025 (PubMed:11586298).Curated1
Sequence conflicti334P → S in BAB69025 (PubMed:11586298).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017107188 – 482Missing in isoform 2. 1 PublicationAdd BLAST295

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055978 mRNA. Translation: BAB71062.1.
AK092310 mRNA. Translation: BAG52528.1.
AL833904 mRNA. Translation: CAD38760.1.
AC010900 Genomic DNA. Translation: AAY24286.1.
AC098831 Genomic DNA. Translation: AAY24091.1.
AC131950 Genomic DNA. Translation: AAY15007.1.
CH471063 Genomic DNA. Translation: EAW70313.1.
BC000993 mRNA. Translation: AAH00993.2.
BC063876 mRNA. Translation: AAH63876.1.
AB053317 mRNA. Translation: BAB69025.1.
CCDSiCCDS2354.1. [Q8NDH6-1]
CCDS74632.1. [Q8NDH6-2]
RefSeqiNP_001275551.1. NM_001288622.1. [Q8NDH6-1]
NP_001275552.1. NM_001288623.1. [Q8NDH6-1]
NP_001275553.1. NM_001288624.1. [Q8NDH6-2]
NP_612477.3. NM_138468.5. [Q8NDH6-1]
UniGeneiHs.516629.

Genome annotation databases

EnsembliENST00000358299; ENSP00000351047; ENSG00000163596. [Q8NDH6-1]
ENST00000392237; ENSP00000376070; ENSG00000163596. [Q8NDH6-1]
ENST00000425178; ENSP00000404189; ENSG00000163596. [Q8NDH6-2]
ENST00000617388; ENSP00000478645; ENSG00000163596. [Q8NDH6-1]
GeneIDi130026.
KEGGihsa:130026.
UCSCiuc002uzh.3. human. [Q8NDH6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiICA1L_HUMAN
AccessioniPrimary (citable) accession number: Q8NDH6
Secondary accession number(s): B3KRW6
, Q53P45, Q53QZ4, Q53T97, Q96N47, Q96Q32, Q9BVQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM