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Protein

Islet cell autoantigen 1-like protein

Gene

ICA1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Islet cell autoantigen 1-like protein
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 14 protein
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein
Gene namesi
Name:ICA1L
Synonyms:ALS2CR14, ALS2CR15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14442. ICA1L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24738.

Polymorphism and mutation databases

BioMutaiICA1L.
DMDMi74751222.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482Islet cell autoantigen 1-like proteinPRO_0000076175Add
BLAST

Proteomic databases

EPDiQ8NDH6.
PaxDbiQ8NDH6.
PRIDEiQ8NDH6.

PTM databases

PhosphoSiteiQ8NDH6.

Expressioni

Gene expression databases

BgeeiQ8NDH6.
CleanExiHS_ICA1L.
ExpressionAtlasiQ8NDH6. baseline and differential.
GenevisibleiQ8NDH6. HS.

Organism-specific databases

HPAiHPA042507.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KIFC3Q9BVG83EBI-10269733,EBI-2125614

Protein-protein interaction databases

BioGridi126218. 2 interactions.
IntActiQ8NDH6. 1 interaction.
STRINGi9606.ENSP00000351047.

Structurei

3D structure databases

ProteinModelPortaliQ8NDH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 247204AHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 AH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3891. Eukaryota.
ENOG410YJKW. LUCA.
GeneTreeiENSGT00390000005530.
HOVERGENiHBG061005.
InParanoidiQ8NDH6.
KOiK19864.
OMAiMSQIHGA.
OrthoDBiEOG7QRQVD.
PhylomeDBiQ8NDH6.
TreeFamiTF317186.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR010504. AH_dom.
IPR024115. Islet_autoAg_Ica1-like.
IPR024114. Islet_autoAg_Ica1/Ica1-like.
IPR006723. Islet_autoAg_Ica1_C.
[Graphical view]
PANTHERiPTHR10164. PTHR10164. 1 hit.
PTHR10164:SF2. PTHR10164:SF2. 1 hit.
PfamiPF06456. Arfaptin. 1 hit.
PF04629. ICA69. 1 hit.
[Graphical view]
SMARTiSM01015. Arfaptin. 1 hit.
SM01237. ICA69. 1 hit.
[Graphical view]
PROSITEiPS50870. AH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NDH6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSFGQPRPE DNQSVVRRMQ KKYWKTKQVF IKATGKKEDE HLVASDAELD
60 70 80 90 100
AKLEVFHSVQ ETCTELLKII EKYQLRLNVI SEEENELGLF LKFQAERDAT
110 120 130 140 150
QAGKMMDATG KALCSSAKQR LALCTPLSRL KQEVATFSQR AVSDTLMTIN
160 170 180 190 200
RMEQARTEYR GALLWMKDVS QELDPDTLKQ MEKFRKVQMQ VRNSKASFDK
210 220 230 240 250
LKMDVCQKVD LLGASRCNML SHSLTTYQRT LLGFWKKTAR MMSQIHEACI
260 270 280 290 300
GFHPYDFVAL KQLQDTPSKI SEDNKDEQIG GFLTEQLNKL VLSDEEASFE
310 320 330 340 350
SEQANKDHNE KHSQMREFGA PQFSNSENVA KDLPVDSLEG EDFEKEFSFL
360 370 380 390 400
NNLLSSGSSS TSEFTQECQT AFGSPSASLT SQEPSMGSEP LAHSSRFLPS
410 420 430 440 450
QLFDLGFHVA GAFNNWVSQE ESELCLSHTD NQPVPSQSPK KLTRSPNNGN
460 470 480
QDMSAWFNLF ADLDPLSNPD AIGHSDDELL NA
Length:482
Mass (Da):54,407
Last modified:October 1, 2002 - v1
Checksum:iCB54E9658DA12DCC
GO
Isoform 2 (identifier: Q8NDH6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-482: Missing.

Note: No experimental confirmation available.
Show »
Length:187
Mass (Da):21,581
Checksum:i26EE3DD4A502225E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti242 – 2421M → V in BAB71062 (PubMed:14702039).Curated
Sequence conflicti294 – 2941D → N in BAB69025 (PubMed:11586298).Curated
Sequence conflicti334 – 3341P → S in BAB69025 (PubMed:11586298).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei188 – 482295Missing in isoform 2. 1 PublicationVSP_017107Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055978 mRNA. Translation: BAB71062.1.
AK092310 mRNA. Translation: BAG52528.1.
AL833904 mRNA. Translation: CAD38760.1.
AC010900 Genomic DNA. Translation: AAY24286.1.
AC098831 Genomic DNA. Translation: AAY24091.1.
AC131950 Genomic DNA. Translation: AAY15007.1.
CH471063 Genomic DNA. Translation: EAW70313.1.
BC000993 mRNA. Translation: AAH00993.2.
BC063876 mRNA. Translation: AAH63876.1.
AB053317 mRNA. Translation: BAB69025.1.
CCDSiCCDS2354.1. [Q8NDH6-1]
CCDS74632.1. [Q8NDH6-2]
RefSeqiNP_001275551.1. NM_001288622.1. [Q8NDH6-1]
NP_001275552.1. NM_001288623.1. [Q8NDH6-1]
NP_001275553.1. NM_001288624.1. [Q8NDH6-2]
NP_612477.3. NM_138468.5. [Q8NDH6-1]
UniGeneiHs.516629.

Genome annotation databases

EnsembliENST00000358299; ENSP00000351047; ENSG00000163596. [Q8NDH6-1]
ENST00000392237; ENSP00000376070; ENSG00000163596. [Q8NDH6-1]
ENST00000425178; ENSP00000404189; ENSG00000163596. [Q8NDH6-2]
ENST00000617388; ENSP00000478645; ENSG00000163596. [Q8NDH6-1]
GeneIDi130026.
KEGGihsa:130026.
UCSCiuc002uzh.3. human. [Q8NDH6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055978 mRNA. Translation: BAB71062.1.
AK092310 mRNA. Translation: BAG52528.1.
AL833904 mRNA. Translation: CAD38760.1.
AC010900 Genomic DNA. Translation: AAY24286.1.
AC098831 Genomic DNA. Translation: AAY24091.1.
AC131950 Genomic DNA. Translation: AAY15007.1.
CH471063 Genomic DNA. Translation: EAW70313.1.
BC000993 mRNA. Translation: AAH00993.2.
BC063876 mRNA. Translation: AAH63876.1.
AB053317 mRNA. Translation: BAB69025.1.
CCDSiCCDS2354.1. [Q8NDH6-1]
CCDS74632.1. [Q8NDH6-2]
RefSeqiNP_001275551.1. NM_001288622.1. [Q8NDH6-1]
NP_001275552.1. NM_001288623.1. [Q8NDH6-1]
NP_001275553.1. NM_001288624.1. [Q8NDH6-2]
NP_612477.3. NM_138468.5. [Q8NDH6-1]
UniGeneiHs.516629.

3D structure databases

ProteinModelPortaliQ8NDH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126218. 2 interactions.
IntActiQ8NDH6. 1 interaction.
STRINGi9606.ENSP00000351047.

PTM databases

PhosphoSiteiQ8NDH6.

Polymorphism and mutation databases

BioMutaiICA1L.
DMDMi74751222.

Proteomic databases

EPDiQ8NDH6.
PaxDbiQ8NDH6.
PRIDEiQ8NDH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358299; ENSP00000351047; ENSG00000163596. [Q8NDH6-1]
ENST00000392237; ENSP00000376070; ENSG00000163596. [Q8NDH6-1]
ENST00000425178; ENSP00000404189; ENSG00000163596. [Q8NDH6-2]
ENST00000617388; ENSP00000478645; ENSG00000163596. [Q8NDH6-1]
GeneIDi130026.
KEGGihsa:130026.
UCSCiuc002uzh.3. human. [Q8NDH6-1]

Organism-specific databases

CTDi130026.
GeneCardsiICA1L.
HGNCiHGNC:14442. ICA1L.
HPAiHPA042507.
neXtProtiNX_Q8NDH6.
PharmGKBiPA24738.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3891. Eukaryota.
ENOG410YJKW. LUCA.
GeneTreeiENSGT00390000005530.
HOVERGENiHBG061005.
InParanoidiQ8NDH6.
KOiK19864.
OMAiMSQIHGA.
OrthoDBiEOG7QRQVD.
PhylomeDBiQ8NDH6.
TreeFamiTF317186.

Miscellaneous databases

ChiTaRSiICA1L. human.
GenomeRNAii130026.
NextBioi82684.
PROiQ8NDH6.

Gene expression databases

BgeeiQ8NDH6.
CleanExiHS_ICA1L.
ExpressionAtlasiQ8NDH6. baseline and differential.
GenevisibleiQ8NDH6. HS.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR010504. AH_dom.
IPR024115. Islet_autoAg_Ica1-like.
IPR024114. Islet_autoAg_Ica1/Ica1-like.
IPR006723. Islet_autoAg_Ica1_C.
[Graphical view]
PANTHERiPTHR10164. PTHR10164. 1 hit.
PTHR10164:SF2. PTHR10164:SF2. 1 hit.
PfamiPF06456. Arfaptin. 1 hit.
PF04629. ICA69. 1 hit.
[Graphical view]
SMARTiSM01015. Arfaptin. 1 hit.
SM01237. ICA69. 1 hit.
[Graphical view]
PROSITEiPS50870. AH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Testis.
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 107-482 (ISOFORM 1).

Entry informationi

Entry nameiICA1L_HUMAN
AccessioniPrimary (citable) accession number: Q8NDH6
Secondary accession number(s): B3KRW6
, Q53P45, Q53QZ4, Q53T97, Q96N47, Q96Q32, Q9BVQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.