ID CC168_HUMAN Reviewed; 7081 AA. AC Q8NDH2; Q8N800; DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot. DT 23-FEB-2022, sequence version 3. DT 27-MAR-2024, entry version 102. DE RecName: Full=Leucine-rich repeat transmembrane protein CCDC168 {ECO:0000305}; DE AltName: Full=Coiled-coil domain-containing protein 168 {ECO:0000312|HGNC:HGNC:26851}; GN Name=CCDC168 {ECO:0000312|HGNC:HGNC:26851}; GN Synonyms=C13orf40 {ECO:0000312|HGNC:HGNC:26851}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057823; DOI=10.1038/nature02379; RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L., RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., RA Frankish A.G., Frankland J., French L., Garner P., Garnett J., RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., RA Rogers J., Ross M.T.; RT "The DNA sequence and analysis of human chromosome 13."; RL Nature 428:522-528(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4630-5357 AND 6000-7081, AND RP VARIANTS PRO-4943; PRO-6011 AND GLU-6544. RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6640-7081. RC TISSUE=Testis; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane CC protein {ECO:0000255}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL157769; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AK097495; BAC05076.1; -; mRNA. DR EMBL; AK125984; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AL833908; CAD38764.1; -; mRNA. DR CCDS; CCDS73596.1; -. DR RefSeq; NP_001139669.1; NM_001146197.1. DR AlphaFoldDB; Q8NDH2; -. DR IntAct; Q8NDH2; 6. DR MINT; Q8NDH2; -. DR STRING; 9606.ENSP00000320232; -. DR GlyGen; Q8NDH2; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q8NDH2; -. DR PhosphoSitePlus; Q8NDH2; -. DR BioMuta; CCDC168; -. DR DMDM; 193806663; -. DR EPD; Q8NDH2; -. DR jPOST; Q8NDH2; -. DR MassIVE; Q8NDH2; -. DR PaxDb; 9606-ENSP00000320232; -. DR PeptideAtlas; Q8NDH2; -. DR ProteomicsDB; 73026; -. DR Antibodypedia; 62446; 10 antibodies from 5 providers. DR Ensembl; ENST00000322527.4; ENSP00000320232.3; ENSG00000175820.4. DR GeneID; 643677; -. DR KEGG; hsa:643677; -. DR MANE-Select; ENST00000322527.4; ENSP00000320232.3; NM_001146197.3; NP_001139669.1. DR UCSC; uc001vpm.4; human. DR AGR; HGNC:26851; -. DR CTD; 643677; -. DR GeneCards; CCDC168; -. DR HGNC; HGNC:26851; CCDC168. DR HPA; ENSG00000175820; Tissue enriched (testis). DR neXtProt; NX_Q8NDH2; -. DR OpenTargets; ENSG00000175820; -. DR VEuPathDB; HostDB:ENSG00000175820; -. DR eggNOG; ENOG502ST12; Eukaryota. DR GeneTree; ENSGT00940000163791; -. DR HOGENOM; CLU_222861_0_0_1; -. DR InParanoid; Q8NDH2; -. DR OMA; DYMQQKE; -. DR PhylomeDB; Q8NDH2; -. DR TreeFam; TF337758; -. DR PathwayCommons; Q8NDH2; -. DR SignaLink; Q8NDH2; -. DR ChiTaRS; CCDC168; human. DR Pharos; Q8NDH2; Tdark. DR PRO; PR:Q8NDH2; -. DR Proteomes; UP000005640; Chromosome 13. DR RNAct; Q8NDH2; Protein. DR Bgee; ENSG00000175820; Expressed in sperm and 11 other cell types or tissues. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR InterPro; IPR031624; CCDC168_N. DR PANTHER; PTHR35542; COILED-COIL DOMAIN-CONTAINING PROTEIN 168; 1. DR PANTHER; PTHR35542:SF1; LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN CCDC168; 1. DR Pfam; PF15804; CCDC168_N; 19. DR Genevisible; Q8NDH2; HS. PE 2: Evidence at transcript level; KW Leucine-rich repeat; Membrane; Reference proteome; Repeat; Transmembrane; KW Transmembrane helix. FT CHAIN 1..7081 FT /note="Leucine-rich repeat transmembrane protein CCDC168" FT /id="PRO_0000342529" FT TRANSMEM 37..57 FT /note="Helical" FT /evidence="ECO:0000255" FT REPEAT 233..256 FT /note="LRR 1" FT /evidence="ECO:0000255" FT REPEAT 420..445 FT /note="LRR 2" FT /evidence="ECO:0000255" FT REPEAT 865..890 FT /note="LRR 3" FT /evidence="ECO:0000255" FT REPEAT 1050..1075 FT /note="LRR 4" FT /evidence="ECO:0000255" FT REPEAT 1501..1527 FT /note="LRR 5" FT /evidence="ECO:0000255" FT REPEAT 2373..2397 FT /note="LRR 6" FT /evidence="ECO:0000255" FT REPEAT 2727..2749 FT /note="LRR 7" FT /evidence="ECO:0000255" FT REPEAT 2832..2855 FT /note="LRR 8" FT /evidence="ECO:0000255" FT REPEAT 2862..2889 FT /note="LRR 9" FT /evidence="ECO:0000255" FT REPEAT 3433..3458 FT /note="LRR 10" FT /evidence="ECO:0000255" FT REPEAT 3630..3653 FT /note="LRR 11" FT /evidence="ECO:0000255" FT REPEAT 3875..3898 FT /note="LRR 12" FT /evidence="ECO:0000255" FT REPEAT 5311..5336 FT /note="LRR 13" FT /evidence="ECO:0000255" FT REPEAT 5522..5545 FT /note="LRR 14" FT /evidence="ECO:0000255" FT REPEAT 5901..5924 FT /note="LRR 15" FT /evidence="ECO:0000255" FT REPEAT 6259..6282 FT /note="LRR 16" FT /evidence="ECO:0000255" FT REPEAT 6419..6442 FT /note="LRR 17" FT /evidence="ECO:0000255" FT REPEAT 6552..6575 FT /note="LRR 18" FT /evidence="ECO:0000255" FT REPEAT 6613..6637 FT /note="LRR 19" FT /evidence="ECO:0000255" FT REPEAT 7012..7036 FT /note="LRR 20" FT /evidence="ECO:0000255" FT REGION 717..745 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 943..1009 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1274..1304 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1773..1804 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1954..1973 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2008..2031 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2083..2103 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2637..2680 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 3730..3756 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 4119..4260 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 4293..4428 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 4729..4756 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 4794..4817 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 4831..4859 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 4928..4955 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 4966..4985 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 5191..5212 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 5467..5496 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 5564..5583 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 5763..5792 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 6859..6878 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 6916..6950 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 943..972 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 984..998 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1773..1787 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2009..2023 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2640..2654 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2663..2680 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 4143..4180 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 4195..4260 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 4326..4363 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 4375..4427 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 4836..4859 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 5472..5496 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 6932..6950 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VARIANT 4659 FT /note="P -> S (in dbSNP:rs11843669)" FT /id="VAR_044210" FT VARIANT 4723 FT /note="M -> V (in dbSNP:rs17592459)" FT /id="VAR_044211" FT VARIANT 4893 FT /note="G -> S (in dbSNP:rs9518825)" FT /id="VAR_044212" FT VARIANT 4943 FT /note="S -> P (in dbSNP:rs9300758)" FT /evidence="ECO:0000269|PubMed:14702039" FT /id="VAR_044213" FT VARIANT 4976 FT /note="L -> P (in dbSNP:rs9300757)" FT /id="VAR_044214" FT VARIANT 5011 FT /note="G -> A (in dbSNP:rs17507841)" FT /id="VAR_044215" FT VARIANT 5644 FT /note="R -> T (in dbSNP:rs7982465)" FT /id="VAR_044216" FT VARIANT 5750 FT /note="N -> S (in dbSNP:rs7983175)" FT /id="VAR_044217" FT VARIANT 5838 FT /note="R -> Q (in dbSNP:rs17592438)" FT /id="VAR_044218" FT VARIANT 5916 FT /note="F -> L (in dbSNP:rs7335290)" FT /id="VAR_044219" FT VARIANT 6011 FT /note="L -> P (in dbSNP:rs6491707)" FT /evidence="ECO:0000269|PubMed:14702039" FT /id="VAR_044220" FT VARIANT 6075 FT /note="R -> C (in dbSNP:rs9300756)" FT /id="VAR_044221" FT VARIANT 6112 FT /note="T -> M (in dbSNP:rs17507827)" FT /id="VAR_044222" FT VARIANT 6508 FT /note="E -> A (in dbSNP:rs9514051)" FT /id="VAR_044223" FT VARIANT 6544 FT /note="K -> E (in dbSNP:rs9554897)" FT /evidence="ECO:0000269|PubMed:14702039" FT /id="VAR_044224" FT CONFLICT 6626 FT /note="L -> P (in Ref. 2; AK125984)" FT /evidence="ECO:0000305" FT CONFLICT 6689..6699 FT /note="LIRKFPQPTLV -> RSEAHTRVG (in Ref. 3; CAD38764)" FT /evidence="ECO:0000305" FT CONFLICT 6865 FT /note="R -> S (in Ref. 2; AK125984)" FT /evidence="ECO:0000305" FT CONFLICT 6908 FT /note="K -> N (in Ref. 2; AK125984)" FT /evidence="ECO:0000305" SQ SEQUENCE 7081 AA; 801912 MW; 6190452D9844F72E CRC64; MSKQYYSFKK GVGSGLEDNT FMTLWDFLES WIIQNDWVAI FFIILLGIIF EIILMKACAS FWKKPTLPEK GSSDVQETED SCPKSRKLAP ENWSVINSSS GERVGTFLEK RITSSLTSEE KECNFEDRIL FSREILWSGT SESEDQVSPS SESHVPSSNG ISSSLPLFYS EVEETCLSHT EHPDREYETI QFSSKKLFSM MKTNKNKNSG FSSDLSFSAS RFTVENEDLD VAPCPLAHLF LSRDQVRLLE ENVRNQIPSK PKTKLGSRTT YQCSRSQESL NQNQPSVGMV ISVQAQDSFP GQNAFQNQGL YEVQFTSQAQ YINHNQESIK SQPESKASNF AQPEDVMKKP FSSSTQDSFQ SQDLDRNQHF VEVPSIVEAK YSVKGLESDE HLGEDQHCVW FIDSNKVKYS IKGQDTIFKN AEFLVLTLNP NLVTEDMPQL RSVKAQGQQQ IVSSELNQDS VYSSVPLLST IKGQKNRRKT PDSKSKLSLN VPSLKAKKTP TSQVFQITVC HTLKNRNELG CKNNTEKKEL HERKDISDIA LHLISVSKLI LPYVKNYSRK QLVKVMPGLI KCGHFLQKQN KSPDTEKINY AGPLEETGIS DITKKEKEYD KENKRLKNIS PKMLPQLEQS FMVNTVQLKA PCLLVETNGK SKESLKDSIT QAKGIGITEF HVLNSKKPFD LHIPKHKTSL EEAISKPMQK LVSSPEMESN NRMKIQEDLQ SSENSHLQLS NGEELPTSTP KTQRCFPREN TQKQKDFLEL VLELSNVGLL ISPGSKMHKS SEELEAIKIQ VNTESVNLKE SKPLILNVTE DSDLRESEEL ECNTGSNITN MHQDKETSDA FHSATYTTIS QLPDTETHSI SKAKADTLRI IRLSHSASKQ EKLPDEKETQ NAEYIDKSCT FKKPQQCDRK EQEKEANSEL TQGFRFSIHL KQKPKYVKFQ MEQISSGSSK APNKEQEVQP QTLSTQTILE NSPCPMMDPF QVEKVKQSTD RPTDRESAGD PKNPLTMPEN LPVGELLIET TEYSVPFGGN LQKTTDSHIA EEKEDVKRYL PAVALGSFNN HLLTLPYFKR QEIKKKLSET KSVLSVKYVI MKVKKPAISL MPYINICGTS NHRKKMGGNF EIIIKQILQD KIAAGMLLNV IYPPMSILPN TRMYSRLNAE NHSHIKLVQE ESQIEREEKY PYFINEGNES QNTLDAKLQD EVKGVKETLP KAVLHDSCNL GLDAHLEKEI KTEKEMHQPI PFTETIIESV VSPIMELSHA ENVKSTQKTQ TDCKCTADSE TPSPISGKSL IGDPLNQTRE SYIPSNGSDT REMGYCFAEE KTEIPKDLPA TSPETFNYCT PVLSCSKVMK KRVTFALTTS TAKPKCVNTK AVKPSISETV SVTSHRKKSE LDFKTKFKKI NQTKGLVPEC LNTLCSPMHS RLQREFCLPA SQLKQGETAD KTYTDVFAKN SISHDREEKL QDGKEEEHKV LLEAAPQLSQ HLGSEAGQMK EIHLESDPVL NCLTLELHIN GQRLQHQTGF EQTTLETSLQ MGPLEAEELQ KANETENDIK VLGGPKIPPP KALQALENSD GLILNAYQKD NELVKSDEEL NQPGSTNIQV QPQTHFTQTI LKSTSCPTLD QFPFEKVESH VRFSPLKSGE AKVDEIIFYA REGGISSDSS HQKEQAGGTE KKETAIFGSC MPALSTPKTT RNLKQFSDMK TLVNPKCGII KAKKPSISYM LNIRAGAGPK RRKELSCNLT TKMKELHQGK KGVDETYAFL TMTPDINKYS KVETEKDTLR EKRLSSTQVK QDTSPHEDSI TSRDIKETLL QDEEQEERKQ EALLKVIPQH LQHFMFRSGQ GKDLDFHKLE NQGSRKILFV TKQDVPQQLQ PAEPIQREET KKCLQTQNGT ICTVNSKLLP LKSEDSVNGE VLTGAIKRGV PTDRKCMGEQ HNSGKGEKAE FNKDLQATVL ELQKSPHGGE AQKANLTDME SGSSNAMNMN VQHEREDKNI QKMLTESVPC YSQHLRFSTH QMKDPDPCKS GSEPKSPEGR SWNLSHIVQK TKQETHFRET VLEPISGYMM KQSPHMQEGI KCMEGLKTSF PKTGKSKIGS IPRDTPWDEN PRRKWDSSIS EKTAWNQKNL QTVLKPLDFS SLMSSEYESR SYTLEFIGKK SMSPKCVTLK AKQLRILQLF NIIRYSTENH RKKKQHRFKY KMKGKQWYTS IGEALLSATE YAKSTTSKSM IDKLLYNTAA RCILSNRTRR QNLDGHITEE KEEVQENVAA IFLGLLDFFM PVLSDSKNQR NTAQLSEKEI IFNAKCLTMK EKKSSISQIH KINRESTRKH RKKCKSYLKT VSNRKCQENH GHITEEEEEV QENSPATFLG PLDFFMPVLS DSKNQINTIQ LSERKIILNP KCLTMKEKKP PISQIHKISG QFTTKHRKKL ESNLKTKLKA MWQGENVADT FPNTTSFTPD SSDIKRQSGF QTEIDMRISG LSHTQPTQIE SLAEGIARYS DPIDKRRTSN LVKGAKLHDR ESGEEKQEHL TEMDPFYAEN FMANTYLRKD RHLGKSEDVL LGETFFSKSQ IYKGNSEKNV KIEKNKNGKE SLKVGLARME KSDNCAELSE ATDDAISNKY DKQNIGHSVL KENAFCNLAA IVPDSVGRHS PASEEMKRQN GRLKMADRSS PQGRPLQAKQ SAVSQSPDTA GYAVVSNNKE QKQNFKAQKT EAEVDLIDQE AKINVAEEFN PESVFFSKIH PLQIENKKEF KTADWKTRAD PKTFALPKKQ QELCVSGTIW SYPNPYTSIS PKIIRHKDKA KTADVESTMH TKQIKLKAKR ITVSQLLEYG TASNKKELRG NIQQQKSFQL SKNAVHRVLK AVYDSGYCVS SIKKLTEVKM EKDKPKDRTC ILPQPKLEKP LKEMQRSLSG CTDMSSILRK QEQDIREKEQ KHQSISEDIS QYYIGPLRIS SQQINYSSFD APRIRTDEEL EFLIAQRAKE KDVGIAKHSV SIPWEREGSK RLDIPLNSKG QNIFFTELDT SQQKTCQEQE LLKQEDISMT NLGSMACPIM EPLHLENTGK VTEEEDVYIN RKISSHVLGK EGLKETDIFV GSKGQKFLCT NSEVQHKVPA EQKEQVNPDH VPESILDSES FLSKDPLHLK QAVNTARKEN VTISESFNEN LWGKEQSKLD ITLKSNRQKM DFSKKLRMKH LSNYYQNKEN ILESVLPCIL HQLYIENPKK EGSAEEIMSS KVLSPMVEKA SHEVGIPVDQ PPCSEGIHLN IKGRKEHPQE STHEAFPASV SHSLMDVLQI KSPKVKKALK AINSLGYLTS NTKGIGLLFP RQAEKEEKYT YKALPKPASH SKTDLFQFNA SMQQEKLDAM DIPHYDYLTS QTREAVKQMD VIVGYTQNSK KRQDLLKTGQ KWQYLPISYE NFWEHISCPQ KYPCLLQHLM PQEKEALSEG GNLSSRTPGL DLFSADQLST ITKNRLEWIV PLISPRQMKK QDSMLPLGSY HKTIKYASLL FPKGMKSSDG VQVFDLISNN SSPKLRLGKK IETQKANEKV QKEVCLPITL HSLSASMPIL QESKGQKDSV EQVIRKGVIC HKRRTSKWKK SVFSHILNTS DCGASSNRLE MQWNMTDKMV NVKHRMSEID LVAAKICESI LSLPHFKLNK ETIDGVISSN VKSTKQHISQ GKNDRVKAMD MKRIKSPNII LKPRKSSLSH ILSIKEFPLL LDIIKQEGKM QEGKGKSSMK LTNLCTSLPS LSHSNSNSRT KAGKDKSGTL KGCLPPLKLQ ASSNARRVSS AESINRDSLS NVIESKCFPQ KKKEDRENIV DVKDVMGLKC ITLKGKKSLF RHLLHGKEPQ RSNKKLEKMT QEDESNLNVV QNKLCASILS PPHLEWNPRI KEVYMRGITR FCLSSSTQQE LSDTMEKCEQ PIDDSLSSIE KAKHMPQKDK DRVEKALEKI MHSKRIALEV KQPSIFQELE LNIKEKGGKI QEDKEVEIWS KPFASISFLP YSKVGTIEGE EAMRIKMRSS FSQPNLQESS DTEKTAYEKC ISDNISNSVK KALESILQKE QRQKMEKIRA LKKMKSSISQ GIQLDIKEQE KRIEHIKGEP SVLLTNACAS IPSPSHLQLD TRREKAEYVT EITRYYLPEL SHQKSSEAGE KADGVASKGD ITIKVQKAKD YMQQKEDDEV KISAKKDIMH PEDKGLKAKK ALSQDLPLNT KEPGKMDQEA QEQGKEDREG EEQGKEDRRG AGQEKVDRED KEQGKMDHEV EEQQKADGVG IEQGKMDGDK NEQERVLFLY LPSNSSLTHY ILDTRIEGEE DQQGIIRPGI LQPRHQKSSE TGKKANGVPS EGDSASEVQK AKDYMQQKEE DEVKISAEKD LMHPEDKDLK GKKALSQNLP LNPKEPGKRD GEGQEQGKED GEGEEQGNRD GETEEQQQAD GVGTEQEKRD GHKSKQETVL FLHLPSESSL TCYELNTRKE GEEDLQGIIK SATLQLRQQK SFDAGKIAHT KSFGVDSSND VKTVQEYKPQ KEVDRGKTVS VDYIMQPEGT IFEAEQLSLP HTLNIPGSSG SKTREVLTNI KEKLRHVQER KSELDVFLTI PSLSHCKLDK RTAGKKEEQG VTRSFLPPSW HMESSDTGKL KYTLSYLNDI TGDSNRTKYM AQIQKDKANI SEKSVMHPEY IAVKAEKSPL SHILKTKELQ VNISQQGEKA QEGEVEIVVL LSKTCPFVTS SAFLELDSIK EEEGEPRITR SFMPHLEIQE SLPSRQTAPT KPTESLVKKE KQLLPQKEDR VQTVSMHGLM HPNGAVFKAK TSAPPQVFSI TEHSPLSKRK EPQWGMKERA GQKQDRTGRP HVILTKTHPF MPSLSHHRFS PSQPKLPISS GAGKSRLANS NEGISSHKVI LKANQQMPYK EAKDRVKIEG REGRILPKRI HLRAEALPLA LLCNGKNYSL HIEEQGEGVQ ESKKEPGVVP RKSASFPPPP FYLNCDTRRN EKEGTLGKTQ FSFPPLKIQD SSDSGKKAYT ESLHGYTLSN SKGPVQPTAQ GEEKGGLRID MEDKMLPKCT DLKAKQLLLS DILNTKKLQW KSKEQKRKIQ EDKNKQVKGL PSINTSLLTP PYLKFDTTEG QENVIRIAKV SLPQSRSKES SDAGRIACPE ATHGELSSDV KQLKAHLLQK EEKDREKVAD MTSVLDPNKM YLKAKKSPVL HTHSFSDLQW KTREQEEEKV QKVKSGPGVM LSKSPSRSSP LHLNVNTGFQ EESIPILTRP SFPLVKLQVS PDTEGGTCIR PIAGDILIYL QKGKHVSQNK EEDDVQIVSI LIFPKHQEEK VQECEGEPGV VLTKSTSLPS LSQLELDKET HLGNEMLRLK RPILRRISHI GETVHRESVV GDIPKDVKNE KQHIPQKEER NQKKIIDMRG TDITLKSKKS PRSCMLHRTE LHVNIGGQGR KEHEGQDKPP GMIQRKMCIL FSKPLPSNLK LERATHADEE RLGGKTSFVL PLMPSALPDT EKTADAEARS GDVRKGKPHR SQKENRHEVK TIDMRFRIHC QEARISPMSH ILNAKELVLN INKLEKKVHK DKDEACVVLS RTFLSIPSAP PLYLDSGNKT DKDTPGITGS SCPQRTLHVP SNTQKITNRD SVEGVDKNVV KQAEQYVPRP EAEQQLTSNF MISVQQRNQP SRVRSEEDLN QLVLNSRDED IYFTGFGTIR SGKRPEWLFT GKKAQPVKYK TETLTAFLSY PTMDATKMGG LEEDTEIMDN LNHKISPKAS VSLIRKISKE LYVTLGTPAN SKGFSVSERY AHQQETSSKV SPELAGSCKF DKPKEDGQSN DRISKMFSPK VLAPQTKGSL KKISIVTNWN APQNIEEQDI VMKKQVIRRC EHGHKTRTNT ILSKFPLQSG KQKTPSETDV DKKTTAHLSL QMLPGIHMDM TEIDPAKGGR KQALLISEQE EGVLEFLPKS LFPPWTFQFQ SGDLEEKHQT DANTNINLEQ KKLEMDNDST VNQKEGKLKI GTNRALHLQE EKTEMHKART ANLEKERGRM DTSSSAHPHL LSLKAEESQM KTQVITHREN SRLIMQKQKK ELEASNAKQS IQLQKLFQRN VLDSFYSYVP LSPKRKDQKG RLTIRDLKRE LSTKYLTMKI QNHPIPQMLN ITGRGTPSNR KKLEYDVKLK NIASWSKDVS GIFIRSLSIS IMRSPHTDPK TNLEREKRIC LPKFQEKSPN TSEMSKRDTL TIVKGEQNFT NTVPQDPQPF AVDKQQMQKL PNVKSEANLR SEMNKKYLKA QTKERIVPEH DVSRIIKKPD LRIIEQEEKI LKRILTPTEC PSMLEDPKLP KQRDQSEPVW DMTTQKVQQQ KAFPGTVPIP PQVKSSEVKI VADSTNAEHL LPICEATKAI SESQVKNMIQ DKVSSDKLDN IQAYKPDDLK SPPFPEGPDT ISTAIYPKTQ HKSLLEQFTP KEKNKLTSHL ESKALEIQLN LIPEMARKSL QMFNFYPKGT ISKDNSWRFY SRHKTMNFMS LEGTDTIEPN SKHKHQKDSP LASNMKTLIV DVSSDSEETI TKLQSINKLE NGTSAVTSAS EMLLPHTLQN HSVKEKGKLL MHFSVKTLEI QMKAFPRIVR ESYAMTSAHE RKKPLSNCIH PGFTGPKRQN RILLLSEEKS LHQIDLDLQY KYLRFLLGLP VGSTFPKPNV LPKHSKLNTI AVCKNVNAGG QSGSLSIDTE LLEQHISFKK QSPHENSSLI RKFPQPTLVC ASDRDLHSPR KKDTQVLSES EFHVTPEKNK QYHVWFQERN TCESVDLRTQ RNATGSAVSC ETQISEDFVD IQTDIESPAD LDECSCLEVS ESEECVFLEA NSYLSQESEN ILFELQTGIP LENVYKITTD LKSFYSEDSG SHCTRECRKE TLIITPPSCK SHKSRKYRSS SKMKSPDWLC HSSSNTAEIQ SRSSSVSFSE EKISWTTKSR TSYSSAPLTE SNIKSHLAKN QGKSHRHPES QERKKARSDL FRKNSSHWDH DYSCTHSKGK RDRKKRVYDY ESERLDCFQS KHKSASKPHH DDINFYSERK QNRPFFFACV PADSLEVIPK TIRWTIPPET LRKRNFRIPL VAKISSSWNI WSSSKKLLGS LSGSLTTVFH S //