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Q8NDH2

- CC168_HUMAN

UniProt

Q8NDH2 - CC168_HUMAN

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Protein
Coiled-coil domain-containing protein 168
Gene
CCDC168, C13orf40
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 168
Gene namesi
Name:CCDC168
Synonyms:C13orf40
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:26851. CCDC168.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24522452Coiled-coil domain-containing protein 168
PRO_0000342529Add
BLAST

Proteomic databases

PaxDbiQ8NDH2.
PRIDEiQ8NDH2.

PTM databases

PhosphoSiteiQ8NDH2.

Expressioni

Gene expression databases

BgeeiQ8NDH2.
GenevestigatoriQ8NDH2.

Organism-specific databases

HPAiHPA048184.

Structurei

3D structure databases

ProteinModelPortaliQ8NDH2.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili891 – 91626 Reviewed prediction
Add
BLAST
Coiled coili1399 – 143133 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi318 – 3214Poly-Pro
Compositional biasi2229 – 228658Ser-rich
Add
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG39507.
InParanoidiQ8NDH2.
OMAiPPLYLDS.
OrthoDBiEOG7W9RSW.
PhylomeDBiQ8NDH2.
TreeFamiTF337758.

Sequencei

Sequence statusi: Complete.

Q8NDH2-1 [UniParc]FASTAAdd to Basket

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MAQIQKDKAN ISEKSVMHPE YIAVKAEKSP LSHILKTKEL QVNISQQGEK     50
AQEGEVEIVV LLSKTCPFVT SSAFLELDSI KEEEGEPRIT RSFMPHLEIQ 100
ESLPSRQTAP TKPTESLVKK EKQLLPQKED RVQTVSMHGL MHPNGAVFKA 150
KTSAPPQVFS ITEHSPLSKR KEPQWGMKER AGQKQDRTGR PHVILTKTHP 200
FMPSLSHHRF SPSQPKLPIS SGAGKSRLAN SNEGISSHKV ILKANQQMPY 250
KEAKDRVKIE GREGRILPKR IHLRAEALPL ALLCNGKNYS LHIEEQGEGV 300
QESKKEPGVV PRKSASFPPP PFYLNCDTRR NEKEGTLGKT QFSFPPLKIQ 350
DSSDSGKKAY TESLHGYTLS NSKGPVQPTA QGEEKGGLRI DMEDKMLPKC 400
TDLKAKQLLL SDILNTKKLQ WKSKEQKRKI QEDKNKQVKG LPSINTSLLT 450
PPYLKFDTTE GQENVIRIAK VSLPQSRSKE SSDAGRIACP EATHGELSSD 500
VKQLKAHLLQ KEEKDREKVA DMTSVLDPNK MYLKAKKSPV LHTHSFSDLQ 550
WKTREQEEEK VQKVKSGPGV MLSKSPSRSS PLHLNVNTGF QEESIPILTR 600
PSFPLVKLQV SPDTEGGTCI RPIAGDILIY LQKGKHVSQN KEEDDVQIVS 650
ILIFPKHQEE KVQECEGEPG VVLTKSTSLP SLSQLELDKE THLGNEMLRL 700
KRPILRRISH IGETVHRESV VGDIPKDVKN EKQHIPQKEE RNQKKIIDMR 750
GTDITLKSKK SPRSCMLHRT ELHVNIGGQG RKEHEGQDKP PGMIQRKMCI 800
LFSKPLPSNL KLERATHADE ERLGGKTSFV LPLMPSALPD TEKTADAEAR 850
SGDVRKGKPH RSQKENRHEV KTIDMRFRIH CQEARISPMS HILNAKELVL 900
NINKLEKKVH KDKDEACVVL SRTFLSIPSA PPLYLDSGNK TDKDTPGITG 950
SSCPQRTLHV PSNTQKITNR DSVEGVDKNV VKQAEQYVPR PEAEQQLTSN 1000
FMISVQQRNQ PSRVRSEEDL NQLVLNSRDE DIYFTGFGTI RSGKRPEWLF 1050
TGKKAQPVKY KTETLTAFLS YPTMDATKMG GLEEDTEIMD NLNHKISPKA 1100
SVSLIRKISK ELYVTLGTPA NSKGFSVSER YAHQQETSSK VSPELAGSCK 1150
FDKPKEDGQS NDRISKMFSP KVLAPQTKGS LKKISIVTNW NAPQNIEEQD 1200
IVMKKQVIRR CEHGHKTRTN TILSKFPLQS GKQKTPSETD VDKKTTAHLS 1250
LQMLPGIHMD MTEIDPAKGG RKQALLISEQ EEGVLEFLPK SLFPPWTFQF 1300
QSGDLEEKHQ TDANTNINLE QKKLEMDNDS TVNQKEGKLK IGTNRALHLQ 1350
EEKTEMHKAR TANLEKERGR MDTSSSAHPH LLSLKAEESQ MKTQVITHRE 1400
NSRLIMQKQK KELEASNAKQ SIQLQKLFQR NVLDSFYSYV PLSPKRKDQK 1450
GRLTIRDLKR ELSTKYLTMK IQNHPIPQML NITGRGTPSN RKKLEYDVKL 1500
KNIASWSKDV SGIFIRSLSI SIMRSPHTDP KTNLEREKRI CLPKFQEKSP 1550
NTSEMSKRDT LTIVKGEQNF TNTVPQDPQP FAVDKQQMQK LPNVKSEANL 1600
RSEMNKKYLK AQTKERIVPE HDVSRIIKKP DLRIIEQEEK ILKRILTPTE 1650
CPSMLEDPKL PKQRDQSEPV WDMTTQKVQQ QKAFPGTVPI PPQVKSSEVK 1700
IVADSTNAEH LLPICEATKA ISESQVKNMI QDKVSSDKLD NIQAYKPDDL 1750
KSPPFPEGPD TISTAIYPKT QHKSLLEQFT PKEKNKLTSH LESKALEIQL 1800
NLIPEMARKS LQMFNFYPKG TISKDNSWRF YSRHKTMNFM SLEGTDTIEP 1850
NSKHKHQKDS PLASNMKTLI VDVSSDSEET ITKLQSINKL ENGTSAVTSA 1900
SEMLLPHTLQ NHSVKEKGKL LMHFSVKTLE IQMKAFPRIV RESYAMTSAH 1950
ERKKPLSNCI HPGFTGPKRQ NRILLLSEEK SLHQIDLDLQ YKYLRFLLGL 2000
PVGSTFPKPN VLPKHSKLNT IAVCKNVNAG GQSGSLSIDT ELLEQHISFK 2050
KQSPHENSSL IRKFPQPTLV CASDRDLHSP RKKDTQVLSE SEFHVTPEKN 2100
KQYHVWFQER NTCESVDLRT QRNATGSAVS CETQISEDFV DIQTDIESPA 2150
DLDECSCLEV SESEECVFLE ANSYLSQESE NILFELQTGI PLENVYKITT 2200
DLKSFYSEDS GSHCTRECRK ETLIITPPSC KSHKSRKYRS SSKMKSPDWL 2250
CHSSSNTAEI QSRSSSVSFS EEKISWTTKS RTSYSSAPLT ESNIKSHLAK 2300
NQGKSHRHPE SQERKKARSD LFRKNSSHWD HDYSCTHSKG KRDRKKRVYD 2350
YESERLDCFQ SKHKSASKPH HDDINFYSER KQNRPFFFAC VPADSLEVIP 2400
KTIRWTIPPE TLRKRNFRIP LVAKISSSWN IWSSSKKLLG SLSGSLTTVF 2450
HS 2452
Length:2,452
Mass (Da):277,951
Last modified:July 1, 2008 - v2
Checksum:iDA929E34C2EDB877
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301P → S.
Corresponds to variant rs11843669 [ dbSNP | Ensembl ].
VAR_044210
Natural varianti94 – 941M → V.
Corresponds to variant rs17592459 [ dbSNP | Ensembl ].
VAR_044211
Natural varianti264 – 2641G → S.
Corresponds to variant rs9518825 [ dbSNP | Ensembl ].
VAR_044212
Natural varianti314 – 3141S → P.1 Publication
Corresponds to variant rs9300758 [ dbSNP | Ensembl ].
VAR_044213
Natural varianti347 – 3471L → P.
Corresponds to variant rs9300757 [ dbSNP | Ensembl ].
VAR_044214
Natural varianti382 – 3821G → A.
Corresponds to variant rs17507841 [ dbSNP | Ensembl ].
VAR_044215
Natural varianti1015 – 10151R → T.
Corresponds to variant rs7982465 [ dbSNP | Ensembl ].
VAR_044216
Natural varianti1121 – 11211N → S.
Corresponds to variant rs7983175 [ dbSNP | Ensembl ].
VAR_044217
Natural varianti1209 – 12091R → Q.
Corresponds to variant rs17592438 [ dbSNP | Ensembl ].
VAR_044218
Natural varianti1287 – 12871F → L.
Corresponds to variant rs7335290 [ dbSNP | Ensembl ].
VAR_044219
Natural varianti1382 – 13821L → P.1 Publication
Corresponds to variant rs6491707 [ dbSNP | Ensembl ].
VAR_044220
Natural varianti1446 – 14461R → C.
Corresponds to variant rs9300756 [ dbSNP | Ensembl ].
VAR_044221
Natural varianti1483 – 14831T → M.
Corresponds to variant rs17507827 [ dbSNP | Ensembl ].
VAR_044222
Natural varianti1879 – 18791E → A.
Corresponds to variant rs9514051 [ dbSNP | Ensembl ].
VAR_044223
Natural varianti1915 – 19151K → E.1 Publication
Corresponds to variant rs9554897 [ dbSNP | Ensembl ].
VAR_044224

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1997 – 19971L → P in AK125984. 1 Publication
Sequence conflicti2060 – 207011LIRKFPQPTLV → RSEAHTRVG in CAD38764. 1 Publication
Add
BLAST
Sequence conflicti2236 – 22361R → S in AK125984. 1 Publication
Sequence conflicti2279 – 22791K → N in AK125984. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL157769 Genomic DNA. No translation available.
AK097495 mRNA. Translation: BAC05076.1.
AK125984 mRNA. No translation available.
AL833908 mRNA. Translation: CAD38764.1.
UniGeneiHs.368382.

Genome annotation databases

EnsembliENST00000322527; ENSP00000320232; ENSG00000175820.

Polymorphism databases

DMDMi193806663.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL157769 Genomic DNA. No translation available.
AK097495 mRNA. Translation: BAC05076.1 .
AK125984 mRNA. No translation available.
AL833908 mRNA. Translation: CAD38764.1 .
UniGenei Hs.368382.

3D structure databases

ProteinModelPortali Q8NDH2.
ModBasei Search...

PTM databases

PhosphoSitei Q8NDH2.

Polymorphism databases

DMDMi 193806663.

Proteomic databases

PaxDbi Q8NDH2.
PRIDEi Q8NDH2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322527 ; ENSP00000320232 ; ENSG00000175820 .

Organism-specific databases

GeneCardsi GC13M103384.
H-InvDB HIX0011441.
HIX0201994.
HGNCi HGNC:26851. CCDC168.
HPAi HPA048184.
neXtProti NX_Q8NDH2.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39507.
InParanoidi Q8NDH2.
OMAi PPLYLDS.
OrthoDBi EOG7W9RSW.
PhylomeDBi Q8NDH2.
TreeFami TF337758.

Miscellaneous databases

PROi Q8NDH2.

Gene expression databases

Bgeei Q8NDH2.
Genevestigatori Q8NDH2.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-728 AND 1371-2452, VARIANTS PRO-314; PRO-1382 AND GLU-1915.
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2011-2452.
    Tissue: Testis.

Entry informationi

Entry nameiCC168_HUMAN
AccessioniPrimary (citable) accession number: Q8NDH2
Secondary accession number(s): Q8N800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: July 9, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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