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Q8NDH2

- CC168_HUMAN

UniProt

Q8NDH2 - CC168_HUMAN

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Protein

Coiled-coil domain-containing protein 168

Gene

CCDC168

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 168
Gene namesi
Name:CCDC168
Synonyms:C13orf40
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:26851. CCDC168.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24522452Coiled-coil domain-containing protein 168PRO_0000342529Add
BLAST

Proteomic databases

PaxDbiQ8NDH2.
PRIDEiQ8NDH2.

PTM databases

PhosphoSiteiQ8NDH2.

Expressioni

Gene expression databases

BgeeiQ8NDH2.
GenevestigatoriQ8NDH2.

Organism-specific databases

HPAiHPA048184.

Structurei

3D structure databases

ProteinModelPortaliQ8NDH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili891 – 91626Sequence AnalysisAdd
BLAST
Coiled coili1399 – 143133Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi318 – 3214Poly-Pro
Compositional biasi2229 – 228658Ser-richAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG39507.
InParanoidiQ8NDH2.
OMAiPPLYLDS.
OrthoDBiEOG7W9RSW.
PhylomeDBiQ8NDH2.
TreeFamiTF337758.

Sequencei

Sequence statusi: Complete.

Q8NDH2-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MAQIQKDKAN ISEKSVMHPE YIAVKAEKSP LSHILKTKEL QVNISQQGEK
60 70 80 90 100
AQEGEVEIVV LLSKTCPFVT SSAFLELDSI KEEEGEPRIT RSFMPHLEIQ
110 120 130 140 150
ESLPSRQTAP TKPTESLVKK EKQLLPQKED RVQTVSMHGL MHPNGAVFKA
160 170 180 190 200
KTSAPPQVFS ITEHSPLSKR KEPQWGMKER AGQKQDRTGR PHVILTKTHP
210 220 230 240 250
FMPSLSHHRF SPSQPKLPIS SGAGKSRLAN SNEGISSHKV ILKANQQMPY
260 270 280 290 300
KEAKDRVKIE GREGRILPKR IHLRAEALPL ALLCNGKNYS LHIEEQGEGV
310 320 330 340 350
QESKKEPGVV PRKSASFPPP PFYLNCDTRR NEKEGTLGKT QFSFPPLKIQ
360 370 380 390 400
DSSDSGKKAY TESLHGYTLS NSKGPVQPTA QGEEKGGLRI DMEDKMLPKC
410 420 430 440 450
TDLKAKQLLL SDILNTKKLQ WKSKEQKRKI QEDKNKQVKG LPSINTSLLT
460 470 480 490 500
PPYLKFDTTE GQENVIRIAK VSLPQSRSKE SSDAGRIACP EATHGELSSD
510 520 530 540 550
VKQLKAHLLQ KEEKDREKVA DMTSVLDPNK MYLKAKKSPV LHTHSFSDLQ
560 570 580 590 600
WKTREQEEEK VQKVKSGPGV MLSKSPSRSS PLHLNVNTGF QEESIPILTR
610 620 630 640 650
PSFPLVKLQV SPDTEGGTCI RPIAGDILIY LQKGKHVSQN KEEDDVQIVS
660 670 680 690 700
ILIFPKHQEE KVQECEGEPG VVLTKSTSLP SLSQLELDKE THLGNEMLRL
710 720 730 740 750
KRPILRRISH IGETVHRESV VGDIPKDVKN EKQHIPQKEE RNQKKIIDMR
760 770 780 790 800
GTDITLKSKK SPRSCMLHRT ELHVNIGGQG RKEHEGQDKP PGMIQRKMCI
810 820 830 840 850
LFSKPLPSNL KLERATHADE ERLGGKTSFV LPLMPSALPD TEKTADAEAR
860 870 880 890 900
SGDVRKGKPH RSQKENRHEV KTIDMRFRIH CQEARISPMS HILNAKELVL
910 920 930 940 950
NINKLEKKVH KDKDEACVVL SRTFLSIPSA PPLYLDSGNK TDKDTPGITG
960 970 980 990 1000
SSCPQRTLHV PSNTQKITNR DSVEGVDKNV VKQAEQYVPR PEAEQQLTSN
1010 1020 1030 1040 1050
FMISVQQRNQ PSRVRSEEDL NQLVLNSRDE DIYFTGFGTI RSGKRPEWLF
1060 1070 1080 1090 1100
TGKKAQPVKY KTETLTAFLS YPTMDATKMG GLEEDTEIMD NLNHKISPKA
1110 1120 1130 1140 1150
SVSLIRKISK ELYVTLGTPA NSKGFSVSER YAHQQETSSK VSPELAGSCK
1160 1170 1180 1190 1200
FDKPKEDGQS NDRISKMFSP KVLAPQTKGS LKKISIVTNW NAPQNIEEQD
1210 1220 1230 1240 1250
IVMKKQVIRR CEHGHKTRTN TILSKFPLQS GKQKTPSETD VDKKTTAHLS
1260 1270 1280 1290 1300
LQMLPGIHMD MTEIDPAKGG RKQALLISEQ EEGVLEFLPK SLFPPWTFQF
1310 1320 1330 1340 1350
QSGDLEEKHQ TDANTNINLE QKKLEMDNDS TVNQKEGKLK IGTNRALHLQ
1360 1370 1380 1390 1400
EEKTEMHKAR TANLEKERGR MDTSSSAHPH LLSLKAEESQ MKTQVITHRE
1410 1420 1430 1440 1450
NSRLIMQKQK KELEASNAKQ SIQLQKLFQR NVLDSFYSYV PLSPKRKDQK
1460 1470 1480 1490 1500
GRLTIRDLKR ELSTKYLTMK IQNHPIPQML NITGRGTPSN RKKLEYDVKL
1510 1520 1530 1540 1550
KNIASWSKDV SGIFIRSLSI SIMRSPHTDP KTNLEREKRI CLPKFQEKSP
1560 1570 1580 1590 1600
NTSEMSKRDT LTIVKGEQNF TNTVPQDPQP FAVDKQQMQK LPNVKSEANL
1610 1620 1630 1640 1650
RSEMNKKYLK AQTKERIVPE HDVSRIIKKP DLRIIEQEEK ILKRILTPTE
1660 1670 1680 1690 1700
CPSMLEDPKL PKQRDQSEPV WDMTTQKVQQ QKAFPGTVPI PPQVKSSEVK
1710 1720 1730 1740 1750
IVADSTNAEH LLPICEATKA ISESQVKNMI QDKVSSDKLD NIQAYKPDDL
1760 1770 1780 1790 1800
KSPPFPEGPD TISTAIYPKT QHKSLLEQFT PKEKNKLTSH LESKALEIQL
1810 1820 1830 1840 1850
NLIPEMARKS LQMFNFYPKG TISKDNSWRF YSRHKTMNFM SLEGTDTIEP
1860 1870 1880 1890 1900
NSKHKHQKDS PLASNMKTLI VDVSSDSEET ITKLQSINKL ENGTSAVTSA
1910 1920 1930 1940 1950
SEMLLPHTLQ NHSVKEKGKL LMHFSVKTLE IQMKAFPRIV RESYAMTSAH
1960 1970 1980 1990 2000
ERKKPLSNCI HPGFTGPKRQ NRILLLSEEK SLHQIDLDLQ YKYLRFLLGL
2010 2020 2030 2040 2050
PVGSTFPKPN VLPKHSKLNT IAVCKNVNAG GQSGSLSIDT ELLEQHISFK
2060 2070 2080 2090 2100
KQSPHENSSL IRKFPQPTLV CASDRDLHSP RKKDTQVLSE SEFHVTPEKN
2110 2120 2130 2140 2150
KQYHVWFQER NTCESVDLRT QRNATGSAVS CETQISEDFV DIQTDIESPA
2160 2170 2180 2190 2200
DLDECSCLEV SESEECVFLE ANSYLSQESE NILFELQTGI PLENVYKITT
2210 2220 2230 2240 2250
DLKSFYSEDS GSHCTRECRK ETLIITPPSC KSHKSRKYRS SSKMKSPDWL
2260 2270 2280 2290 2300
CHSSSNTAEI QSRSSSVSFS EEKISWTTKS RTSYSSAPLT ESNIKSHLAK
2310 2320 2330 2340 2350
NQGKSHRHPE SQERKKARSD LFRKNSSHWD HDYSCTHSKG KRDRKKRVYD
2360 2370 2380 2390 2400
YESERLDCFQ SKHKSASKPH HDDINFYSER KQNRPFFFAC VPADSLEVIP
2410 2420 2430 2440 2450
KTIRWTIPPE TLRKRNFRIP LVAKISSSWN IWSSSKKLLG SLSGSLTTVF

HS
Length:2,452
Mass (Da):277,951
Last modified:July 1, 2008 - v2
Checksum:iDA929E34C2EDB877
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1997 – 19971L → P in AK125984. (PubMed:14702039)Curated
Sequence conflicti2060 – 207011LIRKFPQPTLV → RSEAHTRVG in CAD38764. (PubMed:17974005)CuratedAdd
BLAST
Sequence conflicti2236 – 22361R → S in AK125984. (PubMed:14702039)Curated
Sequence conflicti2279 – 22791K → N in AK125984. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301P → S.
Corresponds to variant rs11843669 [ dbSNP | Ensembl ].
VAR_044210
Natural varianti94 – 941M → V.
Corresponds to variant rs17592459 [ dbSNP | Ensembl ].
VAR_044211
Natural varianti264 – 2641G → S.
Corresponds to variant rs9518825 [ dbSNP | Ensembl ].
VAR_044212
Natural varianti314 – 3141S → P.1 Publication
Corresponds to variant rs9300758 [ dbSNP | Ensembl ].
VAR_044213
Natural varianti347 – 3471L → P.
Corresponds to variant rs9300757 [ dbSNP | Ensembl ].
VAR_044214
Natural varianti382 – 3821G → A.
Corresponds to variant rs17507841 [ dbSNP | Ensembl ].
VAR_044215
Natural varianti1015 – 10151R → T.
Corresponds to variant rs7982465 [ dbSNP | Ensembl ].
VAR_044216
Natural varianti1121 – 11211N → S.
Corresponds to variant rs7983175 [ dbSNP | Ensembl ].
VAR_044217
Natural varianti1209 – 12091R → Q.
Corresponds to variant rs17592438 [ dbSNP | Ensembl ].
VAR_044218
Natural varianti1287 – 12871F → L.
Corresponds to variant rs7335290 [ dbSNP | Ensembl ].
VAR_044219
Natural varianti1382 – 13821L → P.1 Publication
Corresponds to variant rs6491707 [ dbSNP | Ensembl ].
VAR_044220
Natural varianti1446 – 14461R → C.
Corresponds to variant rs9300756 [ dbSNP | Ensembl ].
VAR_044221
Natural varianti1483 – 14831T → M.
Corresponds to variant rs17507827 [ dbSNP | Ensembl ].
VAR_044222
Natural varianti1879 – 18791E → A.
Corresponds to variant rs9514051 [ dbSNP | Ensembl ].
VAR_044223
Natural varianti1915 – 19151K → E.1 Publication
Corresponds to variant rs9554897 [ dbSNP | Ensembl ].
VAR_044224

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157769 Genomic DNA. No translation available.
AK097495 mRNA. Translation: BAC05076.1.
AK125984 mRNA. No translation available.
AL833908 mRNA. Translation: CAD38764.1.
UniGeneiHs.368382.

Genome annotation databases

EnsembliENST00000322527; ENSP00000320232; ENSG00000175820.

Polymorphism databases

DMDMi193806663.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157769 Genomic DNA. No translation available.
AK097495 mRNA. Translation: BAC05076.1 .
AK125984 mRNA. No translation available.
AL833908 mRNA. Translation: CAD38764.1 .
UniGenei Hs.368382.

3D structure databases

ProteinModelPortali Q8NDH2.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8NDH2.

Polymorphism databases

DMDMi 193806663.

Proteomic databases

PaxDbi Q8NDH2.
PRIDEi Q8NDH2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322527 ; ENSP00000320232 ; ENSG00000175820 .

Organism-specific databases

GeneCardsi GC13M103384.
H-InvDB HIX0011441.
HIX0201994.
HGNCi HGNC:26851. CCDC168.
HPAi HPA048184.
neXtProti NX_Q8NDH2.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39507.
InParanoidi Q8NDH2.
OMAi PPLYLDS.
OrthoDBi EOG7W9RSW.
PhylomeDBi Q8NDH2.
TreeFami TF337758.

Miscellaneous databases

PROi Q8NDH2.

Gene expression databases

Bgeei Q8NDH2.
Genevestigatori Q8NDH2.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-728 AND 1371-2452, VARIANTS PRO-314; PRO-1382 AND GLU-1915.
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2011-2452.
    Tissue: Testis.

Entry informationi

Entry nameiCC168_HUMAN
AccessioniPrimary (citable) accession number: Q8NDH2
Secondary accession number(s): Q8N800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: October 1, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3