Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8NDH2

- CC168_HUMAN

UniProt

Q8NDH2 - CC168_HUMAN

Protein

Coiled-coil domain-containing protein 168

Gene

CCDC168

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 2 (01 Jul 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 168
    Gene namesi
    Name:CCDC168
    Synonyms:C13orf40
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:26851. CCDC168.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 24522452Coiled-coil domain-containing protein 168PRO_0000342529Add
    BLAST

    Proteomic databases

    PaxDbiQ8NDH2.
    PRIDEiQ8NDH2.

    PTM databases

    PhosphoSiteiQ8NDH2.

    Expressioni

    Gene expression databases

    BgeeiQ8NDH2.
    GenevestigatoriQ8NDH2.

    Organism-specific databases

    HPAiHPA048184.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NDH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili891 – 91626Sequence AnalysisAdd
    BLAST
    Coiled coili1399 – 143133Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi318 – 3214Poly-Pro
    Compositional biasi2229 – 228658Ser-richAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG39507.
    InParanoidiQ8NDH2.
    OMAiPPLYLDS.
    OrthoDBiEOG7W9RSW.
    PhylomeDBiQ8NDH2.
    TreeFamiTF337758.

    Sequencei

    Sequence statusi: Complete.

    Q8NDH2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQIQKDKAN ISEKSVMHPE YIAVKAEKSP LSHILKTKEL QVNISQQGEK     50
    AQEGEVEIVV LLSKTCPFVT SSAFLELDSI KEEEGEPRIT RSFMPHLEIQ 100
    ESLPSRQTAP TKPTESLVKK EKQLLPQKED RVQTVSMHGL MHPNGAVFKA 150
    KTSAPPQVFS ITEHSPLSKR KEPQWGMKER AGQKQDRTGR PHVILTKTHP 200
    FMPSLSHHRF SPSQPKLPIS SGAGKSRLAN SNEGISSHKV ILKANQQMPY 250
    KEAKDRVKIE GREGRILPKR IHLRAEALPL ALLCNGKNYS LHIEEQGEGV 300
    QESKKEPGVV PRKSASFPPP PFYLNCDTRR NEKEGTLGKT QFSFPPLKIQ 350
    DSSDSGKKAY TESLHGYTLS NSKGPVQPTA QGEEKGGLRI DMEDKMLPKC 400
    TDLKAKQLLL SDILNTKKLQ WKSKEQKRKI QEDKNKQVKG LPSINTSLLT 450
    PPYLKFDTTE GQENVIRIAK VSLPQSRSKE SSDAGRIACP EATHGELSSD 500
    VKQLKAHLLQ KEEKDREKVA DMTSVLDPNK MYLKAKKSPV LHTHSFSDLQ 550
    WKTREQEEEK VQKVKSGPGV MLSKSPSRSS PLHLNVNTGF QEESIPILTR 600
    PSFPLVKLQV SPDTEGGTCI RPIAGDILIY LQKGKHVSQN KEEDDVQIVS 650
    ILIFPKHQEE KVQECEGEPG VVLTKSTSLP SLSQLELDKE THLGNEMLRL 700
    KRPILRRISH IGETVHRESV VGDIPKDVKN EKQHIPQKEE RNQKKIIDMR 750
    GTDITLKSKK SPRSCMLHRT ELHVNIGGQG RKEHEGQDKP PGMIQRKMCI 800
    LFSKPLPSNL KLERATHADE ERLGGKTSFV LPLMPSALPD TEKTADAEAR 850
    SGDVRKGKPH RSQKENRHEV KTIDMRFRIH CQEARISPMS HILNAKELVL 900
    NINKLEKKVH KDKDEACVVL SRTFLSIPSA PPLYLDSGNK TDKDTPGITG 950
    SSCPQRTLHV PSNTQKITNR DSVEGVDKNV VKQAEQYVPR PEAEQQLTSN 1000
    FMISVQQRNQ PSRVRSEEDL NQLVLNSRDE DIYFTGFGTI RSGKRPEWLF 1050
    TGKKAQPVKY KTETLTAFLS YPTMDATKMG GLEEDTEIMD NLNHKISPKA 1100
    SVSLIRKISK ELYVTLGTPA NSKGFSVSER YAHQQETSSK VSPELAGSCK 1150
    FDKPKEDGQS NDRISKMFSP KVLAPQTKGS LKKISIVTNW NAPQNIEEQD 1200
    IVMKKQVIRR CEHGHKTRTN TILSKFPLQS GKQKTPSETD VDKKTTAHLS 1250
    LQMLPGIHMD MTEIDPAKGG RKQALLISEQ EEGVLEFLPK SLFPPWTFQF 1300
    QSGDLEEKHQ TDANTNINLE QKKLEMDNDS TVNQKEGKLK IGTNRALHLQ 1350
    EEKTEMHKAR TANLEKERGR MDTSSSAHPH LLSLKAEESQ MKTQVITHRE 1400
    NSRLIMQKQK KELEASNAKQ SIQLQKLFQR NVLDSFYSYV PLSPKRKDQK 1450
    GRLTIRDLKR ELSTKYLTMK IQNHPIPQML NITGRGTPSN RKKLEYDVKL 1500
    KNIASWSKDV SGIFIRSLSI SIMRSPHTDP KTNLEREKRI CLPKFQEKSP 1550
    NTSEMSKRDT LTIVKGEQNF TNTVPQDPQP FAVDKQQMQK LPNVKSEANL 1600
    RSEMNKKYLK AQTKERIVPE HDVSRIIKKP DLRIIEQEEK ILKRILTPTE 1650
    CPSMLEDPKL PKQRDQSEPV WDMTTQKVQQ QKAFPGTVPI PPQVKSSEVK 1700
    IVADSTNAEH LLPICEATKA ISESQVKNMI QDKVSSDKLD NIQAYKPDDL 1750
    KSPPFPEGPD TISTAIYPKT QHKSLLEQFT PKEKNKLTSH LESKALEIQL 1800
    NLIPEMARKS LQMFNFYPKG TISKDNSWRF YSRHKTMNFM SLEGTDTIEP 1850
    NSKHKHQKDS PLASNMKTLI VDVSSDSEET ITKLQSINKL ENGTSAVTSA 1900
    SEMLLPHTLQ NHSVKEKGKL LMHFSVKTLE IQMKAFPRIV RESYAMTSAH 1950
    ERKKPLSNCI HPGFTGPKRQ NRILLLSEEK SLHQIDLDLQ YKYLRFLLGL 2000
    PVGSTFPKPN VLPKHSKLNT IAVCKNVNAG GQSGSLSIDT ELLEQHISFK 2050
    KQSPHENSSL IRKFPQPTLV CASDRDLHSP RKKDTQVLSE SEFHVTPEKN 2100
    KQYHVWFQER NTCESVDLRT QRNATGSAVS CETQISEDFV DIQTDIESPA 2150
    DLDECSCLEV SESEECVFLE ANSYLSQESE NILFELQTGI PLENVYKITT 2200
    DLKSFYSEDS GSHCTRECRK ETLIITPPSC KSHKSRKYRS SSKMKSPDWL 2250
    CHSSSNTAEI QSRSSSVSFS EEKISWTTKS RTSYSSAPLT ESNIKSHLAK 2300
    NQGKSHRHPE SQERKKARSD LFRKNSSHWD HDYSCTHSKG KRDRKKRVYD 2350
    YESERLDCFQ SKHKSASKPH HDDINFYSER KQNRPFFFAC VPADSLEVIP 2400
    KTIRWTIPPE TLRKRNFRIP LVAKISSSWN IWSSSKKLLG SLSGSLTTVF 2450
    HS 2452
    Length:2,452
    Mass (Da):277,951
    Last modified:July 1, 2008 - v2
    Checksum:iDA929E34C2EDB877
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1997 – 19971L → P in AK125984. (PubMed:14702039)Curated
    Sequence conflicti2060 – 207011LIRKFPQPTLV → RSEAHTRVG in CAD38764. (PubMed:17974005)CuratedAdd
    BLAST
    Sequence conflicti2236 – 22361R → S in AK125984. (PubMed:14702039)Curated
    Sequence conflicti2279 – 22791K → N in AK125984. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti30 – 301P → S.
    Corresponds to variant rs11843669 [ dbSNP | Ensembl ].
    VAR_044210
    Natural varianti94 – 941M → V.
    Corresponds to variant rs17592459 [ dbSNP | Ensembl ].
    VAR_044211
    Natural varianti264 – 2641G → S.
    Corresponds to variant rs9518825 [ dbSNP | Ensembl ].
    VAR_044212
    Natural varianti314 – 3141S → P.1 Publication
    Corresponds to variant rs9300758 [ dbSNP | Ensembl ].
    VAR_044213
    Natural varianti347 – 3471L → P.
    Corresponds to variant rs9300757 [ dbSNP | Ensembl ].
    VAR_044214
    Natural varianti382 – 3821G → A.
    Corresponds to variant rs17507841 [ dbSNP | Ensembl ].
    VAR_044215
    Natural varianti1015 – 10151R → T.
    Corresponds to variant rs7982465 [ dbSNP | Ensembl ].
    VAR_044216
    Natural varianti1121 – 11211N → S.
    Corresponds to variant rs7983175 [ dbSNP | Ensembl ].
    VAR_044217
    Natural varianti1209 – 12091R → Q.
    Corresponds to variant rs17592438 [ dbSNP | Ensembl ].
    VAR_044218
    Natural varianti1287 – 12871F → L.
    Corresponds to variant rs7335290 [ dbSNP | Ensembl ].
    VAR_044219
    Natural varianti1382 – 13821L → P.1 Publication
    Corresponds to variant rs6491707 [ dbSNP | Ensembl ].
    VAR_044220
    Natural varianti1446 – 14461R → C.
    Corresponds to variant rs9300756 [ dbSNP | Ensembl ].
    VAR_044221
    Natural varianti1483 – 14831T → M.
    Corresponds to variant rs17507827 [ dbSNP | Ensembl ].
    VAR_044222
    Natural varianti1879 – 18791E → A.
    Corresponds to variant rs9514051 [ dbSNP | Ensembl ].
    VAR_044223
    Natural varianti1915 – 19151K → E.1 Publication
    Corresponds to variant rs9554897 [ dbSNP | Ensembl ].
    VAR_044224

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL157769 Genomic DNA. No translation available.
    AK097495 mRNA. Translation: BAC05076.1.
    AK125984 mRNA. No translation available.
    AL833908 mRNA. Translation: CAD38764.1.
    UniGeneiHs.368382.

    Genome annotation databases

    EnsembliENST00000322527; ENSP00000320232; ENSG00000175820.

    Polymorphism databases

    DMDMi193806663.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL157769 Genomic DNA. No translation available.
    AK097495 mRNA. Translation: BAC05076.1 .
    AK125984 mRNA. No translation available.
    AL833908 mRNA. Translation: CAD38764.1 .
    UniGenei Hs.368382.

    3D structure databases

    ProteinModelPortali Q8NDH2.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8NDH2.

    Polymorphism databases

    DMDMi 193806663.

    Proteomic databases

    PaxDbi Q8NDH2.
    PRIDEi Q8NDH2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322527 ; ENSP00000320232 ; ENSG00000175820 .

    Organism-specific databases

    GeneCardsi GC13M103384.
    H-InvDB HIX0011441.
    HIX0201994.
    HGNCi HGNC:26851. CCDC168.
    HPAi HPA048184.
    neXtProti NX_Q8NDH2.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39507.
    InParanoidi Q8NDH2.
    OMAi PPLYLDS.
    OrthoDBi EOG7W9RSW.
    PhylomeDBi Q8NDH2.
    TreeFami TF337758.

    Miscellaneous databases

    PROi Q8NDH2.

    Gene expression databases

    Bgeei Q8NDH2.
    Genevestigatori Q8NDH2.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-728 AND 1371-2452, VARIANTS PRO-314; PRO-1382 AND GLU-1915.
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2011-2452.
      Tissue: Testis.

    Entry informationi

    Entry nameiCC168_HUMAN
    AccessioniPrimary (citable) accession number: Q8NDH2
    Secondary accession number(s): Q8N800
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 58 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3