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Q8NDH2 (CC168_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coiled-coil domain-containing protein 168
Gene names
Name:CCDC168
Synonyms:C13orf40
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2452 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 24522452Coiled-coil domain-containing protein 168
PRO_0000342529

Regions

Coiled coil891 – 91626 Potential
Coiled coil1399 – 143133 Potential
Compositional bias318 – 3214Poly-Pro
Compositional bias2229 – 228658Ser-rich

Natural variations

Natural variant301P → S.
Corresponds to variant rs11843669 [ dbSNP | Ensembl ].
VAR_044210
Natural variant941M → V.
Corresponds to variant rs17592459 [ dbSNP | Ensembl ].
VAR_044211
Natural variant2641G → S.
Corresponds to variant rs9518825 [ dbSNP | Ensembl ].
VAR_044212
Natural variant3141S → P. Ref.2
Corresponds to variant rs9300758 [ dbSNP | Ensembl ].
VAR_044213
Natural variant3471L → P.
Corresponds to variant rs9300757 [ dbSNP | Ensembl ].
VAR_044214
Natural variant3821G → A.
Corresponds to variant rs17507841 [ dbSNP | Ensembl ].
VAR_044215
Natural variant10151R → T.
Corresponds to variant rs7982465 [ dbSNP | Ensembl ].
VAR_044216
Natural variant11211N → S.
Corresponds to variant rs7983175 [ dbSNP | Ensembl ].
VAR_044217
Natural variant12091R → Q.
Corresponds to variant rs17592438 [ dbSNP | Ensembl ].
VAR_044218
Natural variant12871F → L.
Corresponds to variant rs7335290 [ dbSNP | Ensembl ].
VAR_044219
Natural variant13821L → P. Ref.2
Corresponds to variant rs6491707 [ dbSNP | Ensembl ].
VAR_044220
Natural variant14461R → C.
Corresponds to variant rs9300756 [ dbSNP | Ensembl ].
VAR_044221
Natural variant14831T → M.
Corresponds to variant rs17507827 [ dbSNP | Ensembl ].
VAR_044222
Natural variant18791E → A.
Corresponds to variant rs9514051 [ dbSNP | Ensembl ].
VAR_044223
Natural variant19151K → E. Ref.2
Corresponds to variant rs9554897 [ dbSNP | Ensembl ].
VAR_044224

Experimental info

Sequence conflict19971L → P in AK125984. Ref.2
Sequence conflict2060 – 207011LIRKFPQPTLV → RSEAHTRVG in CAD38764. Ref.3
Sequence conflict22361R → S in AK125984. Ref.2
Sequence conflict22791K → N in AK125984. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8NDH2 [UniParc].

Last modified July 1, 2008. Version 2.
Checksum: DA929E34C2EDB877

FASTA2,452277,951
        10         20         30         40         50         60 
MAQIQKDKAN ISEKSVMHPE YIAVKAEKSP LSHILKTKEL QVNISQQGEK AQEGEVEIVV 

        70         80         90        100        110        120 
LLSKTCPFVT SSAFLELDSI KEEEGEPRIT RSFMPHLEIQ ESLPSRQTAP TKPTESLVKK 

       130        140        150        160        170        180 
EKQLLPQKED RVQTVSMHGL MHPNGAVFKA KTSAPPQVFS ITEHSPLSKR KEPQWGMKER 

       190        200        210        220        230        240 
AGQKQDRTGR PHVILTKTHP FMPSLSHHRF SPSQPKLPIS SGAGKSRLAN SNEGISSHKV 

       250        260        270        280        290        300 
ILKANQQMPY KEAKDRVKIE GREGRILPKR IHLRAEALPL ALLCNGKNYS LHIEEQGEGV 

       310        320        330        340        350        360 
QESKKEPGVV PRKSASFPPP PFYLNCDTRR NEKEGTLGKT QFSFPPLKIQ DSSDSGKKAY 

       370        380        390        400        410        420 
TESLHGYTLS NSKGPVQPTA QGEEKGGLRI DMEDKMLPKC TDLKAKQLLL SDILNTKKLQ 

       430        440        450        460        470        480 
WKSKEQKRKI QEDKNKQVKG LPSINTSLLT PPYLKFDTTE GQENVIRIAK VSLPQSRSKE 

       490        500        510        520        530        540 
SSDAGRIACP EATHGELSSD VKQLKAHLLQ KEEKDREKVA DMTSVLDPNK MYLKAKKSPV 

       550        560        570        580        590        600 
LHTHSFSDLQ WKTREQEEEK VQKVKSGPGV MLSKSPSRSS PLHLNVNTGF QEESIPILTR 

       610        620        630        640        650        660 
PSFPLVKLQV SPDTEGGTCI RPIAGDILIY LQKGKHVSQN KEEDDVQIVS ILIFPKHQEE 

       670        680        690        700        710        720 
KVQECEGEPG VVLTKSTSLP SLSQLELDKE THLGNEMLRL KRPILRRISH IGETVHRESV 

       730        740        750        760        770        780 
VGDIPKDVKN EKQHIPQKEE RNQKKIIDMR GTDITLKSKK SPRSCMLHRT ELHVNIGGQG 

       790        800        810        820        830        840 
RKEHEGQDKP PGMIQRKMCI LFSKPLPSNL KLERATHADE ERLGGKTSFV LPLMPSALPD 

       850        860        870        880        890        900 
TEKTADAEAR SGDVRKGKPH RSQKENRHEV KTIDMRFRIH CQEARISPMS HILNAKELVL 

       910        920        930        940        950        960 
NINKLEKKVH KDKDEACVVL SRTFLSIPSA PPLYLDSGNK TDKDTPGITG SSCPQRTLHV 

       970        980        990       1000       1010       1020 
PSNTQKITNR DSVEGVDKNV VKQAEQYVPR PEAEQQLTSN FMISVQQRNQ PSRVRSEEDL 

      1030       1040       1050       1060       1070       1080 
NQLVLNSRDE DIYFTGFGTI RSGKRPEWLF TGKKAQPVKY KTETLTAFLS YPTMDATKMG 

      1090       1100       1110       1120       1130       1140 
GLEEDTEIMD NLNHKISPKA SVSLIRKISK ELYVTLGTPA NSKGFSVSER YAHQQETSSK 

      1150       1160       1170       1180       1190       1200 
VSPELAGSCK FDKPKEDGQS NDRISKMFSP KVLAPQTKGS LKKISIVTNW NAPQNIEEQD 

      1210       1220       1230       1240       1250       1260 
IVMKKQVIRR CEHGHKTRTN TILSKFPLQS GKQKTPSETD VDKKTTAHLS LQMLPGIHMD 

      1270       1280       1290       1300       1310       1320 
MTEIDPAKGG RKQALLISEQ EEGVLEFLPK SLFPPWTFQF QSGDLEEKHQ TDANTNINLE 

      1330       1340       1350       1360       1370       1380 
QKKLEMDNDS TVNQKEGKLK IGTNRALHLQ EEKTEMHKAR TANLEKERGR MDTSSSAHPH 

      1390       1400       1410       1420       1430       1440 
LLSLKAEESQ MKTQVITHRE NSRLIMQKQK KELEASNAKQ SIQLQKLFQR NVLDSFYSYV 

      1450       1460       1470       1480       1490       1500 
PLSPKRKDQK GRLTIRDLKR ELSTKYLTMK IQNHPIPQML NITGRGTPSN RKKLEYDVKL 

      1510       1520       1530       1540       1550       1560 
KNIASWSKDV SGIFIRSLSI SIMRSPHTDP KTNLEREKRI CLPKFQEKSP NTSEMSKRDT 

      1570       1580       1590       1600       1610       1620 
LTIVKGEQNF TNTVPQDPQP FAVDKQQMQK LPNVKSEANL RSEMNKKYLK AQTKERIVPE 

      1630       1640       1650       1660       1670       1680 
HDVSRIIKKP DLRIIEQEEK ILKRILTPTE CPSMLEDPKL PKQRDQSEPV WDMTTQKVQQ 

      1690       1700       1710       1720       1730       1740 
QKAFPGTVPI PPQVKSSEVK IVADSTNAEH LLPICEATKA ISESQVKNMI QDKVSSDKLD 

      1750       1760       1770       1780       1790       1800 
NIQAYKPDDL KSPPFPEGPD TISTAIYPKT QHKSLLEQFT PKEKNKLTSH LESKALEIQL 

      1810       1820       1830       1840       1850       1860 
NLIPEMARKS LQMFNFYPKG TISKDNSWRF YSRHKTMNFM SLEGTDTIEP NSKHKHQKDS 

      1870       1880       1890       1900       1910       1920 
PLASNMKTLI VDVSSDSEET ITKLQSINKL ENGTSAVTSA SEMLLPHTLQ NHSVKEKGKL 

      1930       1940       1950       1960       1970       1980 
LMHFSVKTLE IQMKAFPRIV RESYAMTSAH ERKKPLSNCI HPGFTGPKRQ NRILLLSEEK 

      1990       2000       2010       2020       2030       2040 
SLHQIDLDLQ YKYLRFLLGL PVGSTFPKPN VLPKHSKLNT IAVCKNVNAG GQSGSLSIDT 

      2050       2060       2070       2080       2090       2100 
ELLEQHISFK KQSPHENSSL IRKFPQPTLV CASDRDLHSP RKKDTQVLSE SEFHVTPEKN 

      2110       2120       2130       2140       2150       2160 
KQYHVWFQER NTCESVDLRT QRNATGSAVS CETQISEDFV DIQTDIESPA DLDECSCLEV 

      2170       2180       2190       2200       2210       2220 
SESEECVFLE ANSYLSQESE NILFELQTGI PLENVYKITT DLKSFYSEDS GSHCTRECRK 

      2230       2240       2250       2260       2270       2280 
ETLIITPPSC KSHKSRKYRS SSKMKSPDWL CHSSSNTAEI QSRSSSVSFS EEKISWTTKS 

      2290       2300       2310       2320       2330       2340 
RTSYSSAPLT ESNIKSHLAK NQGKSHRHPE SQERKKARSD LFRKNSSHWD HDYSCTHSKG 

      2350       2360       2370       2380       2390       2400 
KRDRKKRVYD YESERLDCFQ SKHKSASKPH HDDINFYSER KQNRPFFFAC VPADSLEVIP 

      2410       2420       2430       2440       2450 
KTIRWTIPPE TLRKRNFRIP LVAKISSSWN IWSSSKKLLG SLSGSLTTVF HS 

« Hide

References

[1]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-728 AND 1371-2452, VARIANTS PRO-314; PRO-1382 AND GLU-1915.
Tissue: Testis.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2011-2452.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL157769 Genomic DNA. No translation available.
AK097495 mRNA. Translation: BAC05076.1.
AK125984 mRNA. No translation available.
AL833908 mRNA. Translation: CAD38764.1.
UniGeneHs.368382.

3D structure databases

ProteinModelPortalQ8NDH2.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8NDH2.

Polymorphism databases

DMDM193806663.

Proteomic databases

PaxDbQ8NDH2.
PRIDEQ8NDH2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000322527; ENSP00000320232; ENSG00000175820.

Organism-specific databases

GeneCardsGC13M103384.
H-InvDBHIX0011441.
HIX0201994.
HGNCHGNC:26851. CCDC168.
HPAHPA048184.
neXtProtNX_Q8NDH2.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39507.
InParanoidQ8NDH2.
OMALQYKYLR.
OrthoDBEOG7W9RSW.
TreeFamTF337758.

Gene expression databases

BgeeQ8NDH2.
GenevestigatorQ8NDH2.

Family and domain databases

ProtoNetSearch...

Other

PROQ8NDH2.

Entry information

Entry nameCC168_HUMAN
AccessionPrimary (citable) accession number: Q8NDH2
Secondary accession number(s): Q8N800
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: February 19, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM