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Protein

Coiled-coil domain-containing protein 168

Gene

CCDC168

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 168
Gene namesi
Name:CCDC168
Synonyms:C13orf40
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:26851. CCDC168.

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi193806663.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003425291 – 2452Coiled-coil domain-containing protein 168Add BLAST2452

Proteomic databases

EPDiQ8NDH2.
PaxDbiQ8NDH2.
PeptideAtlasiQ8NDH2.
PRIDEiQ8NDH2.

PTM databases

iPTMnetiQ8NDH2.
PhosphoSitePlusiQ8NDH2.

Expressioni

Gene expression databases

BgeeiENSG00000175820.
GenevisibleiQ8NDH2. HS.

Organism-specific databases

HPAiHPA048184.
HPA058793.

Interactioni

Protein-protein interaction databases

IntActiQ8NDH2. 1 interactor.
STRINGi9606.ENSP00000320232.

Structurei

3D structure databases

ProteinModelPortaliQ8NDH2.
SMRiQ8NDH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili891 – 916Sequence analysisAdd BLAST26
Coiled coili1399 – 1431Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi318 – 321Poly-Pro4
Compositional biasi2229 – 2286Ser-richAdd BLAST58

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J8MZ. Eukaryota.
ENOG411167Q. LUCA.
InParanoidiQ8NDH2.
OrthoDBiEOG091G0045.
PhylomeDBiQ8NDH2.
TreeFamiTF337758.

Family and domain databases

InterProiIPR031624. CCDC168_N.
[Graphical view]
PfamiPF15804. CCDC168_N. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NDH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQIQKDKAN ISEKSVMHPE YIAVKAEKSP LSHILKTKEL QVNISQQGEK
60 70 80 90 100
AQEGEVEIVV LLSKTCPFVT SSAFLELDSI KEEEGEPRIT RSFMPHLEIQ
110 120 130 140 150
ESLPSRQTAP TKPTESLVKK EKQLLPQKED RVQTVSMHGL MHPNGAVFKA
160 170 180 190 200
KTSAPPQVFS ITEHSPLSKR KEPQWGMKER AGQKQDRTGR PHVILTKTHP
210 220 230 240 250
FMPSLSHHRF SPSQPKLPIS SGAGKSRLAN SNEGISSHKV ILKANQQMPY
260 270 280 290 300
KEAKDRVKIE GREGRILPKR IHLRAEALPL ALLCNGKNYS LHIEEQGEGV
310 320 330 340 350
QESKKEPGVV PRKSASFPPP PFYLNCDTRR NEKEGTLGKT QFSFPPLKIQ
360 370 380 390 400
DSSDSGKKAY TESLHGYTLS NSKGPVQPTA QGEEKGGLRI DMEDKMLPKC
410 420 430 440 450
TDLKAKQLLL SDILNTKKLQ WKSKEQKRKI QEDKNKQVKG LPSINTSLLT
460 470 480 490 500
PPYLKFDTTE GQENVIRIAK VSLPQSRSKE SSDAGRIACP EATHGELSSD
510 520 530 540 550
VKQLKAHLLQ KEEKDREKVA DMTSVLDPNK MYLKAKKSPV LHTHSFSDLQ
560 570 580 590 600
WKTREQEEEK VQKVKSGPGV MLSKSPSRSS PLHLNVNTGF QEESIPILTR
610 620 630 640 650
PSFPLVKLQV SPDTEGGTCI RPIAGDILIY LQKGKHVSQN KEEDDVQIVS
660 670 680 690 700
ILIFPKHQEE KVQECEGEPG VVLTKSTSLP SLSQLELDKE THLGNEMLRL
710 720 730 740 750
KRPILRRISH IGETVHRESV VGDIPKDVKN EKQHIPQKEE RNQKKIIDMR
760 770 780 790 800
GTDITLKSKK SPRSCMLHRT ELHVNIGGQG RKEHEGQDKP PGMIQRKMCI
810 820 830 840 850
LFSKPLPSNL KLERATHADE ERLGGKTSFV LPLMPSALPD TEKTADAEAR
860 870 880 890 900
SGDVRKGKPH RSQKENRHEV KTIDMRFRIH CQEARISPMS HILNAKELVL
910 920 930 940 950
NINKLEKKVH KDKDEACVVL SRTFLSIPSA PPLYLDSGNK TDKDTPGITG
960 970 980 990 1000
SSCPQRTLHV PSNTQKITNR DSVEGVDKNV VKQAEQYVPR PEAEQQLTSN
1010 1020 1030 1040 1050
FMISVQQRNQ PSRVRSEEDL NQLVLNSRDE DIYFTGFGTI RSGKRPEWLF
1060 1070 1080 1090 1100
TGKKAQPVKY KTETLTAFLS YPTMDATKMG GLEEDTEIMD NLNHKISPKA
1110 1120 1130 1140 1150
SVSLIRKISK ELYVTLGTPA NSKGFSVSER YAHQQETSSK VSPELAGSCK
1160 1170 1180 1190 1200
FDKPKEDGQS NDRISKMFSP KVLAPQTKGS LKKISIVTNW NAPQNIEEQD
1210 1220 1230 1240 1250
IVMKKQVIRR CEHGHKTRTN TILSKFPLQS GKQKTPSETD VDKKTTAHLS
1260 1270 1280 1290 1300
LQMLPGIHMD MTEIDPAKGG RKQALLISEQ EEGVLEFLPK SLFPPWTFQF
1310 1320 1330 1340 1350
QSGDLEEKHQ TDANTNINLE QKKLEMDNDS TVNQKEGKLK IGTNRALHLQ
1360 1370 1380 1390 1400
EEKTEMHKAR TANLEKERGR MDTSSSAHPH LLSLKAEESQ MKTQVITHRE
1410 1420 1430 1440 1450
NSRLIMQKQK KELEASNAKQ SIQLQKLFQR NVLDSFYSYV PLSPKRKDQK
1460 1470 1480 1490 1500
GRLTIRDLKR ELSTKYLTMK IQNHPIPQML NITGRGTPSN RKKLEYDVKL
1510 1520 1530 1540 1550
KNIASWSKDV SGIFIRSLSI SIMRSPHTDP KTNLEREKRI CLPKFQEKSP
1560 1570 1580 1590 1600
NTSEMSKRDT LTIVKGEQNF TNTVPQDPQP FAVDKQQMQK LPNVKSEANL
1610 1620 1630 1640 1650
RSEMNKKYLK AQTKERIVPE HDVSRIIKKP DLRIIEQEEK ILKRILTPTE
1660 1670 1680 1690 1700
CPSMLEDPKL PKQRDQSEPV WDMTTQKVQQ QKAFPGTVPI PPQVKSSEVK
1710 1720 1730 1740 1750
IVADSTNAEH LLPICEATKA ISESQVKNMI QDKVSSDKLD NIQAYKPDDL
1760 1770 1780 1790 1800
KSPPFPEGPD TISTAIYPKT QHKSLLEQFT PKEKNKLTSH LESKALEIQL
1810 1820 1830 1840 1850
NLIPEMARKS LQMFNFYPKG TISKDNSWRF YSRHKTMNFM SLEGTDTIEP
1860 1870 1880 1890 1900
NSKHKHQKDS PLASNMKTLI VDVSSDSEET ITKLQSINKL ENGTSAVTSA
1910 1920 1930 1940 1950
SEMLLPHTLQ NHSVKEKGKL LMHFSVKTLE IQMKAFPRIV RESYAMTSAH
1960 1970 1980 1990 2000
ERKKPLSNCI HPGFTGPKRQ NRILLLSEEK SLHQIDLDLQ YKYLRFLLGL
2010 2020 2030 2040 2050
PVGSTFPKPN VLPKHSKLNT IAVCKNVNAG GQSGSLSIDT ELLEQHISFK
2060 2070 2080 2090 2100
KQSPHENSSL IRKFPQPTLV CASDRDLHSP RKKDTQVLSE SEFHVTPEKN
2110 2120 2130 2140 2150
KQYHVWFQER NTCESVDLRT QRNATGSAVS CETQISEDFV DIQTDIESPA
2160 2170 2180 2190 2200
DLDECSCLEV SESEECVFLE ANSYLSQESE NILFELQTGI PLENVYKITT
2210 2220 2230 2240 2250
DLKSFYSEDS GSHCTRECRK ETLIITPPSC KSHKSRKYRS SSKMKSPDWL
2260 2270 2280 2290 2300
CHSSSNTAEI QSRSSSVSFS EEKISWTTKS RTSYSSAPLT ESNIKSHLAK
2310 2320 2330 2340 2350
NQGKSHRHPE SQERKKARSD LFRKNSSHWD HDYSCTHSKG KRDRKKRVYD
2360 2370 2380 2390 2400
YESERLDCFQ SKHKSASKPH HDDINFYSER KQNRPFFFAC VPADSLEVIP
2410 2420 2430 2440 2450
KTIRWTIPPE TLRKRNFRIP LVAKISSSWN IWSSSKKLLG SLSGSLTTVF

HS
Length:2,452
Mass (Da):277,951
Last modified:July 1, 2008 - v2
Checksum:iDA929E34C2EDB877
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1997L → P in AK125984 (PubMed:14702039).Curated1
Sequence conflicti2060 – 2070LIRKFPQPTLV → RSEAHTRVG in CAD38764 (PubMed:17974005).CuratedAdd BLAST11
Sequence conflicti2236R → S in AK125984 (PubMed:14702039).Curated1
Sequence conflicti2279K → N in AK125984 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04421030P → S.Corresponds to variant rs11843669dbSNPEnsembl.1
Natural variantiVAR_04421194M → V.Corresponds to variant rs17592459dbSNPEnsembl.1
Natural variantiVAR_044212264G → S.Corresponds to variant rs9518825dbSNPEnsembl.1
Natural variantiVAR_044213314S → P.1 PublicationCorresponds to variant rs9300758dbSNPEnsembl.1
Natural variantiVAR_044214347L → P.Corresponds to variant rs9300757dbSNPEnsembl.1
Natural variantiVAR_044215382G → A.Corresponds to variant rs17507841dbSNPEnsembl.1
Natural variantiVAR_0442161015R → T.Corresponds to variant rs7982465dbSNPEnsembl.1
Natural variantiVAR_0442171121N → S.Corresponds to variant rs7983175dbSNPEnsembl.1
Natural variantiVAR_0442181209R → Q.Corresponds to variant rs17592438dbSNPEnsembl.1
Natural variantiVAR_0442191287F → L.Corresponds to variant rs7335290dbSNPEnsembl.1
Natural variantiVAR_0442201382L → P.1 PublicationCorresponds to variant rs6491707dbSNPEnsembl.1
Natural variantiVAR_0442211446R → C.Corresponds to variant rs9300756dbSNPEnsembl.1
Natural variantiVAR_0442221483T → M.Corresponds to variant rs17507827dbSNPEnsembl.1
Natural variantiVAR_0442231879E → A.Corresponds to variant rs9514051dbSNPEnsembl.1
Natural variantiVAR_0442241915K → E.1 PublicationCorresponds to variant rs9554897dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157769 Genomic DNA. No translation available.
AK097495 mRNA. Translation: BAC05076.1.
AK125984 mRNA. No translation available.
AL833908 mRNA. Translation: CAD38764.1.
UniGeneiHs.368382.

Genome annotation databases

EnsembliENST00000322527; ENSP00000320232; ENSG00000175820.
UCSCiuc001vpm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157769 Genomic DNA. No translation available.
AK097495 mRNA. Translation: BAC05076.1.
AK125984 mRNA. No translation available.
AL833908 mRNA. Translation: CAD38764.1.
UniGeneiHs.368382.

3D structure databases

ProteinModelPortaliQ8NDH2.
SMRiQ8NDH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8NDH2. 1 interactor.
STRINGi9606.ENSP00000320232.

PTM databases

iPTMnetiQ8NDH2.
PhosphoSitePlusiQ8NDH2.

Polymorphism and mutation databases

DMDMi193806663.

Proteomic databases

EPDiQ8NDH2.
PaxDbiQ8NDH2.
PeptideAtlasiQ8NDH2.
PRIDEiQ8NDH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322527; ENSP00000320232; ENSG00000175820.
UCSCiuc001vpm.4. human.

Organism-specific databases

GeneCardsiCCDC168.
H-InvDBHIX0011441.
HIX0201994.
HGNCiHGNC:26851. CCDC168.
HPAiHPA048184.
HPA058793.
neXtProtiNX_Q8NDH2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8MZ. Eukaryota.
ENOG411167Q. LUCA.
InParanoidiQ8NDH2.
OrthoDBiEOG091G0045.
PhylomeDBiQ8NDH2.
TreeFamiTF337758.

Miscellaneous databases

PROiQ8NDH2.

Gene expression databases

BgeeiENSG00000175820.
GenevisibleiQ8NDH2. HS.

Family and domain databases

InterProiIPR031624. CCDC168_N.
[Graphical view]
PfamiPF15804. CCDC168_N. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCC168_HUMAN
AccessioniPrimary (citable) accession number: Q8NDH2
Secondary accession number(s): Q8N800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 2, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.