Q8NDH2 (CC168_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coiled-coil domain-containing protein 168

Gene names

Name:	CCDC168
Synonyms:	C13orf40

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2452 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2452	2452	Coiled-coil domain-containing protein 168		PRO_0000342529
Regions
	Coiled coil	891 – 916	26	Potential
	Coiled coil	1399 – 1431	33	Potential
	Compositional bias	318 – 321	4	Poly-Pro
	Compositional bias	2229 – 2286	58	Ser-rich
Natural variations
	Natural variant	30	1	P → S. Corresponds to variant rs11843669 [ dbSNP | Ensembl ].		VAR_044210
	Natural variant	94	1	M → V. Corresponds to variant rs17592459 [ dbSNP | Ensembl ].		VAR_044211
	Natural variant	264	1	G → S. Corresponds to variant rs9518825 [ dbSNP | Ensembl ].		VAR_044212
	Natural variant	314	1	S → P. Ref.2 Corresponds to variant rs9300758 [ dbSNP | Ensembl ].		VAR_044213
	Natural variant	347	1	L → P. Corresponds to variant rs9300757 [ dbSNP | Ensembl ].		VAR_044214
	Natural variant	382	1	G → A. Corresponds to variant rs17507841 [ dbSNP | Ensembl ].		VAR_044215
	Natural variant	1015	1	R → T. Corresponds to variant rs7982465 [ dbSNP | Ensembl ].		VAR_044216
	Natural variant	1121	1	N → S. Corresponds to variant rs7983175 [ dbSNP | Ensembl ].		VAR_044217
	Natural variant	1209	1	R → Q. Corresponds to variant rs17592438 [ dbSNP | Ensembl ].		VAR_044218
	Natural variant	1287	1	F → L. Corresponds to variant rs7335290 [ dbSNP | Ensembl ].		VAR_044219
	Natural variant	1382	1	L → P. Ref.2 Corresponds to variant rs6491707 [ dbSNP | Ensembl ].		VAR_044220
	Natural variant	1446	1	R → C. Corresponds to variant rs9300756 [ dbSNP | Ensembl ].		VAR_044221
	Natural variant	1483	1	T → M. Corresponds to variant rs17507827 [ dbSNP | Ensembl ].		VAR_044222
	Natural variant	1879	1	E → A. Corresponds to variant rs9514051 [ dbSNP | Ensembl ].		VAR_044223
	Natural variant	1915	1	K → E. Ref.2 Corresponds to variant rs9554897 [ dbSNP | Ensembl ].		VAR_044224
Experimental info
	Sequence conflict	1997	1	L → P in AK125984. Ref.2
	Sequence conflict	2060 – 2070	11	LIRKFPQPTLV → RSEAHTRVG in CAD38764. Ref.3
	Sequence conflict	2236	1	R → S in AK125984. Ref.2
	Sequence conflict	2279	1	K → N in AK125984. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8NDH2 [UniParc]. Last modified July 1, 2008. Version 2. Checksum: DA929E34C2EDB877	FASTA	2,452	277,951
	10 20 30 40 50 60 MAQIQKDKAN ISEKSVMHPE YIAVKAEKSP LSHILKTKEL QVNISQQGEK AQEGEVEIVV 70 80 90 100 110 120 LLSKTCPFVT SSAFLELDSI KEEEGEPRIT RSFMPHLEIQ ESLPSRQTAP TKPTESLVKK 130 140 150 160 170 180 EKQLLPQKED RVQTVSMHGL MHPNGAVFKA KTSAPPQVFS ITEHSPLSKR KEPQWGMKER 190 200 210 220 230 240 AGQKQDRTGR PHVILTKTHP FMPSLSHHRF SPSQPKLPIS SGAGKSRLAN SNEGISSHKV 250 260 270 280 290 300 ILKANQQMPY KEAKDRVKIE GREGRILPKR IHLRAEALPL ALLCNGKNYS LHIEEQGEGV 310 320 330 340 350 360 QESKKEPGVV PRKSASFPPP PFYLNCDTRR NEKEGTLGKT QFSFPPLKIQ DSSDSGKKAY 370 380 390 400 410 420 TESLHGYTLS NSKGPVQPTA QGEEKGGLRI DMEDKMLPKC TDLKAKQLLL SDILNTKKLQ 430 440 450 460 470 480 WKSKEQKRKI QEDKNKQVKG LPSINTSLLT PPYLKFDTTE GQENVIRIAK VSLPQSRSKE 490 500 510 520 530 540 SSDAGRIACP EATHGELSSD VKQLKAHLLQ KEEKDREKVA DMTSVLDPNK MYLKAKKSPV 550 560 570 580 590 600 LHTHSFSDLQ WKTREQEEEK VQKVKSGPGV MLSKSPSRSS PLHLNVNTGF QEESIPILTR 610 620 630 640 650 660 PSFPLVKLQV SPDTEGGTCI RPIAGDILIY LQKGKHVSQN KEEDDVQIVS ILIFPKHQEE 670 680 690 700 710 720 KVQECEGEPG VVLTKSTSLP SLSQLELDKE THLGNEMLRL KRPILRRISH IGETVHRESV 730 740 750 760 770 780 VGDIPKDVKN EKQHIPQKEE RNQKKIIDMR GTDITLKSKK SPRSCMLHRT ELHVNIGGQG 790 800 810 820 830 840 RKEHEGQDKP PGMIQRKMCI LFSKPLPSNL KLERATHADE ERLGGKTSFV LPLMPSALPD 850 860 870 880 890 900 TEKTADAEAR SGDVRKGKPH RSQKENRHEV KTIDMRFRIH CQEARISPMS HILNAKELVL 910 920 930 940 950 960 NINKLEKKVH KDKDEACVVL SRTFLSIPSA PPLYLDSGNK TDKDTPGITG SSCPQRTLHV 970 980 990 1000 1010 1020 PSNTQKITNR DSVEGVDKNV VKQAEQYVPR PEAEQQLTSN FMISVQQRNQ PSRVRSEEDL 1030 1040 1050 1060 1070 1080 NQLVLNSRDE DIYFTGFGTI RSGKRPEWLF TGKKAQPVKY KTETLTAFLS YPTMDATKMG 1090 1100 1110 1120 1130 1140 GLEEDTEIMD NLNHKISPKA SVSLIRKISK ELYVTLGTPA NSKGFSVSER YAHQQETSSK 1150 1160 1170 1180 1190 1200 VSPELAGSCK FDKPKEDGQS NDRISKMFSP KVLAPQTKGS LKKISIVTNW NAPQNIEEQD 1210 1220 1230 1240 1250 1260 IVMKKQVIRR CEHGHKTRTN TILSKFPLQS GKQKTPSETD VDKKTTAHLS LQMLPGIHMD 1270 1280 1290 1300 1310 1320 MTEIDPAKGG RKQALLISEQ EEGVLEFLPK SLFPPWTFQF QSGDLEEKHQ TDANTNINLE 1330 1340 1350 1360 1370 1380 QKKLEMDNDS TVNQKEGKLK IGTNRALHLQ EEKTEMHKAR TANLEKERGR MDTSSSAHPH 1390 1400 1410 1420 1430 1440 LLSLKAEESQ MKTQVITHRE NSRLIMQKQK KELEASNAKQ SIQLQKLFQR NVLDSFYSYV 1450 1460 1470 1480 1490 1500 PLSPKRKDQK GRLTIRDLKR ELSTKYLTMK IQNHPIPQML NITGRGTPSN RKKLEYDVKL 1510 1520 1530 1540 1550 1560 KNIASWSKDV SGIFIRSLSI SIMRSPHTDP KTNLEREKRI CLPKFQEKSP NTSEMSKRDT 1570 1580 1590 1600 1610 1620 LTIVKGEQNF TNTVPQDPQP FAVDKQQMQK LPNVKSEANL RSEMNKKYLK AQTKERIVPE 1630 1640 1650 1660 1670 1680 HDVSRIIKKP DLRIIEQEEK ILKRILTPTE CPSMLEDPKL PKQRDQSEPV WDMTTQKVQQ 1690 1700 1710 1720 1730 1740 QKAFPGTVPI PPQVKSSEVK IVADSTNAEH LLPICEATKA ISESQVKNMI QDKVSSDKLD 1750 1760 1770 1780 1790 1800 NIQAYKPDDL KSPPFPEGPD TISTAIYPKT QHKSLLEQFT PKEKNKLTSH LESKALEIQL 1810 1820 1830 1840 1850 1860 NLIPEMARKS LQMFNFYPKG TISKDNSWRF YSRHKTMNFM SLEGTDTIEP NSKHKHQKDS 1870 1880 1890 1900 1910 1920 PLASNMKTLI VDVSSDSEET ITKLQSINKL ENGTSAVTSA SEMLLPHTLQ NHSVKEKGKL 1930 1940 1950 1960 1970 1980 LMHFSVKTLE IQMKAFPRIV RESYAMTSAH ERKKPLSNCI HPGFTGPKRQ NRILLLSEEK 1990 2000 2010 2020 2030 2040 SLHQIDLDLQ YKYLRFLLGL PVGSTFPKPN VLPKHSKLNT IAVCKNVNAG GQSGSLSIDT 2050 2060 2070 2080 2090 2100 ELLEQHISFK KQSPHENSSL IRKFPQPTLV CASDRDLHSP RKKDTQVLSE SEFHVTPEKN 2110 2120 2130 2140 2150 2160 KQYHVWFQER NTCESVDLRT QRNATGSAVS CETQISEDFV DIQTDIESPA DLDECSCLEV 2170 2180 2190 2200 2210 2220 SESEECVFLE ANSYLSQESE NILFELQTGI PLENVYKITT DLKSFYSEDS GSHCTRECRK 2230 2240 2250 2260 2270 2280 ETLIITPPSC KSHKSRKYRS SSKMKSPDWL CHSSSNTAEI QSRSSSVSFS EEKISWTTKS 2290 2300 2310 2320 2330 2340 RTSYSSAPLT ESNIKSHLAK NQGKSHRHPE SQERKKARSD LFRKNSSHWD HDYSCTHSKG 2350 2360 2370 2380 2390 2400 KRDRKKRVYD YESERLDCFQ SKHKSASKPH HDDINFYSER KQNRPFFFAC VPADSLEVIP 2410 2420 2430 2440 2450 KTIRWTIPPE TLRKRNFRIP LVAKISSSWN IWSSSKKLLG SLSGSLTTVF HS

References

[1]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-728 AND 1371-2452, VARIANTS PRO-314; PRO-1382 AND GLU-1915. Tissue: Testis.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2011-2452. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL157769 Genomic DNA. No translation available. AK097495 mRNA. Translation: BAC05076.1. AK125984 mRNA. No translation available. AL833908 mRNA. Translation: CAD38764.1.
IPI	IPI00929313.
UniGene	Hs.368382.
3D structure databases
ProteinModelPortal	Q8NDH2.
ModBase	Search...
PTM databases
PhosphoSite	Q8NDH2.
Polymorphism databases
DMDM	193806663.
Proteomic databases
PaxDb	Q8NDH2.
PRIDE	Q8NDH2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322527; ENSP00000320232; ENSG00000175820.
Organism-specific databases
GeneCards	GC13M103384.
H-InvDB	HIX0011441. HIX0201994.
HGNC	HGNC:26851. CCDC168.
HPA	HPA048184.
neXtProt	NX_Q8NDH2.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG39507.
InParanoid	Q8NDH2.
OMA	LQYKYLR.
OrthoDB	EOG4H19WC.
Gene expression databases
Bgee	Q8NDH2.
Genevestigator	Q8NDH2.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CC168_HUMAN

Accession

Primary (citable) accession number: Q8NDH2
Secondary accession number(s): Q8N800

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	March 6, 2013
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.