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Q8NDG6

- TDRD9_HUMAN

UniProt

Q8NDG6 - TDRD9_HUMAN

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Protein

Putative ATP-dependent RNA helicase TDRD9

Gene
TDRD9, C14orf75
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with PIWIL4 and the piP-bodies suggests a participation in the secondary piRNAs metabolic process By similarity.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi155 – 1628ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. DNA methylation involved in gamete generation Source: UniProtKB
  3. fertilization Source: UniProtKB
  4. gene silencing by RNA Source: UniProtKB-KW
  5. male meiosis Source: UniProtKB
  6. multicellular organismal development Source: UniProtKB-KW
  7. piRNA metabolic process Source: UniProtKB
  8. spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Helicase, Hydrolase

Keywords - Biological processi

Differentiation, Meiosis, RNA-mediated gene silencing, Spermatogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase TDRD9 (EC:3.6.4.13)
Alternative name(s):
Tudor domain-containing protein 9
Gene namesi
Name:TDRD9
Synonyms:C14orf75
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20122. TDRD9.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies By similarity.

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. piP-body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134890186.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13821382Putative ATP-dependent RNA helicase TDRD9PRO_0000333813Add
BLAST

Proteomic databases

PaxDbiQ8NDG6.
PRIDEiQ8NDG6.

PTM databases

PhosphoSiteiQ8NDG6.

Expressioni

Gene expression databases

BgeeiQ8NDG6.
CleanExiHS_TDRD9.
GenevestigatoriQ8NDG6.

Organism-specific databases

HPAiHPA038120.

Interactioni

Subunit structurei

Interacts with piRNA-associated proteins PIWIL1 and PIWIL4 By similarity.

Protein-protein interaction databases

BioGridi125766. 1 interaction.
STRINGi9606.ENSP00000387303.

Structurei

3D structure databases

ProteinModelPortaliQ8NDG6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini142 – 308167Helicase ATP-bindingAdd
BLAST
Domaini377 – 544168Helicase C-terminalAdd
BLAST
Domaini944 – 100461TudorAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi254 – 2574DEAH box

Sequence similaritiesi

Contains 1 Tudor domain.

Phylogenomic databases

eggNOGiCOG1643.
InParanoidiQ8NDG6.
OMAiINDWFTI.
OrthoDBiEOG7FV3PF.
PhylomeDBiQ8NDG6.
TreeFamiTF324869.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR002999. Tudor.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00567. TUDOR. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SM00333. TUDOR. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50304. TUDOR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NDG6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLRKLTIEQI NDWFTIGKTV TNVELLGAPP AFPAGAAREE VQRQDVAPGA     50
GPAAQAPALA QAPARPAAAF ERSLSQRSSE VEYINKYRQL EAQELDVCRS 100
VQPTSGPGPR PSLAKLSSVT CIPGTTYKYP DLPISRYKEE VVSLIESNSV 150
VIIHGATGSG KSTQLPQYIL DHYVQRSAYC SIVVTQPRKI GASSIARWIS 200
KERAWTLGGV VGYQVGLEKI ATEDTRLIYM TTGVLLQKIV SAKSLMEFTH 250
IIIDEVHERT EEMDFLLLVV RKLLRTNSRF VKVVLMSATI SCKEFADYFA 300
VPVQNKMNPA YIFEVEGKPH SVEEYYLNDL EHIHHSKLSP HLLEEPVITK 350
DIYEVAVSLI QMFDDLDMKE SGNKAWSGAQ FVLERSSVLV FLPGLGEINY 400
MHELLTSLVH KRLQVYPLHS SVALEEQNNV FLSPVPGYRK IILSTNIAES 450
SVTVPDVKYV IDFCLTRTLV CDEDTNYQSL RLSWASKTSC NQRKGRAGRV 500
SRGYCYRLVH KDFWDNSIPD HVVPEMLRCP LGSTILKVKL LDMGEPRALL 550
ATALSPPGLS DIERTILLLK EVGALAVSGQ REDENPHDGE LTFLGRVLAQ 600
LPVNQQLGKL IVLGHVFGCL DECLIIAAAL SLKNFFAMPF RQHLDGYRNK 650
VNFSGSSKSD CIALVEAFKT WKACRQTGEL RYPKDELNWG RLNYIQIKRI 700
REVAELYEEL KTRISQFNMH VDSRRPVMDQ EYIYKQRFIL QVVLAGAFYP 750
NYFTFGQPDE EMAVRELAGK DPKTTVVLKH IPPYGFLYYK QLQSLFRQCG 800
QVKSIVFDGA KAFVEFSRNP TERFKTLPAV YMAIKMSQLK VSLELSVHSA 850
EEIEGKVQGM NVSKLRNTRV NVDFQKQTVD PMQVSFNTSD RSQTVTDLLL 900
TIDVTEVVEV GHFWGYRIDE NNSEILKKLT AEINQLTLVP LPTHPHPDLV 950
CLAPFADFDK QRYFRAQVLY VSGNSAEVFF VDYGNKSHVD LHLLMEIPCQ 1000
FLELPFQALE FKICKMRPSA KSLVCGKHWS DGASQWFASL VSGCTLLVKV 1050
FSVVHSVLHV DVYQYSGVQD AINIRDVLIQ QGYAELTEES YESKQSHEVL 1100
KGLFSKSVEN MTDGSVPFPM KDDEKYLIRI LLESFSTNKL GTPNCKAELH 1150
GPFNPYELKC HSLTRISKFR CVWIEKESIN SVIISDAPED LHQRMLVAAS 1200
LSINATGSTM LLRETSLMPH IPGLPALLSM LFAPVIELRI DQNGKYYTGV 1250
LCGLGWNPAT GASILPEHDM ELAFDVQFSV EDVVEVNILR AAINKLVCDG 1300
PNGCKCLGPE RVAQLQDIAR QKLLGLFCQS KPREKIVPKW HEKPYEWNQV 1350
DPKLVMEQAD RESSRGKNTF LYQLHKLVVL GT 1382
Length:1,382
Mass (Da):155,683
Last modified:March 2, 2010 - v3
Checksum:i8A48E71E4A12041F
GO
Isoform 2 (identifier: Q8NDG6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1095-1285: Missing.

Note: No experimental confirmation available.

Show »
Length:1,191
Mass (Da):134,466
Checksum:i6362D3EA9EAC4D2D
GO

Sequence cautioni

The sequence AAI28058.1 differs from that shown. Reason: Frameshift at position 1159.
The sequence AAI28058.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC04182.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC05047.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC05144.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC86372.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1095 – 1285191Missing in isoform 2. VSP_033552Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti758 – 7581P → L in BAC05047. 1 Publication
Sequence conflicti1260 – 12601T → G in AAH16796. 1 Publication
Sequence conflicti1276 – 12761V → F in BAC05144. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL132712 Genomic DNA. No translation available.
AL136001 Genomic DNA. No translation available.
AL833915 mRNA. Translation: CAD38771.1.
AK093483 mRNA. Translation: BAC04182.1. Different initiation.
AK097429 mRNA. Translation: BAC05047.1. Different initiation.
AK097699 mRNA. Translation: BAC05144.1. Different initiation.
AK125978 mRNA. Translation: BAC86372.1. Different initiation.
BC016796 mRNA. Translation: AAH16796.1.
BC128057 mRNA. Translation: AAI28058.1. Sequence problems.
CCDSiCCDS9987.2. [Q8NDG6-1]
PIRiG02632.
RefSeqiNP_694591.2. NM_153046.2. [Q8NDG6-1]
UniGeneiHs.21454.

Genome annotation databases

EnsembliENST00000339063; ENSP00000343545; ENSG00000156414. [Q8NDG6-2]
ENST00000409874; ENSP00000387303; ENSG00000156414. [Q8NDG6-1]
GeneIDi122402.
KEGGihsa:122402.
UCSCiuc001yom.4. human. [Q8NDG6-1]
uc001yon.4. human. [Q8NDG6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL132712 Genomic DNA. No translation available.
AL136001 Genomic DNA. No translation available.
AL833915 mRNA. Translation: CAD38771.1 .
AK093483 mRNA. Translation: BAC04182.1 . Different initiation.
AK097429 mRNA. Translation: BAC05047.1 . Different initiation.
AK097699 mRNA. Translation: BAC05144.1 . Different initiation.
AK125978 mRNA. Translation: BAC86372.1 . Different initiation.
BC016796 mRNA. Translation: AAH16796.1 .
BC128057 mRNA. Translation: AAI28058.1 . Sequence problems.
CCDSi CCDS9987.2. [Q8NDG6-1 ]
PIRi G02632.
RefSeqi NP_694591.2. NM_153046.2. [Q8NDG6-1 ]
UniGenei Hs.21454.

3D structure databases

ProteinModelPortali Q8NDG6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125766. 1 interaction.
STRINGi 9606.ENSP00000387303.

PTM databases

PhosphoSitei Q8NDG6.

Proteomic databases

PaxDbi Q8NDG6.
PRIDEi Q8NDG6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339063 ; ENSP00000343545 ; ENSG00000156414 . [Q8NDG6-2 ]
ENST00000409874 ; ENSP00000387303 ; ENSG00000156414 . [Q8NDG6-1 ]
GeneIDi 122402.
KEGGi hsa:122402.
UCSCi uc001yom.4. human. [Q8NDG6-1 ]
uc001yon.4. human. [Q8NDG6-2 ]

Organism-specific databases

CTDi 122402.
GeneCardsi GC14P104394.
HGNCi HGNC:20122. TDRD9.
HPAi HPA038120.
neXtProti NX_Q8NDG6.
PharmGKBi PA134890186.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1643.
InParanoidi Q8NDG6.
OMAi INDWFTI.
OrthoDBi EOG7FV3PF.
PhylomeDBi Q8NDG6.
TreeFami TF324869.

Miscellaneous databases

GenomeRNAii 122402.
NextBioi 80877.
PROi Q8NDG6.

Gene expression databases

Bgeei Q8NDG6.
CleanExi HS_TDRD9.
Genevestigatori Q8NDG6.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR002999. Tudor.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00567. TUDOR. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SM00333. TUDOR. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50304. TUDOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 195-1382 (ISOFORM 1).
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 275-1382 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 635-1382 (ISOFORM 1).
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 278-1382 (ISOFORM 1).
    Tissue: Bone marrow.

Entry informationi

Entry nameiTDRD9_HUMAN
AccessioniPrimary (citable) accession number: Q8NDG6
Secondary accession number(s): A1A4S7
, Q6ZU54, Q8N7T3, Q8N827, Q8N9V5, Q96AS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 2, 2010
Last modified: September 3, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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