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Protein

Non-canonical poly(A) RNA polymerase PAPD5

Gene

PAPD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion.2 Publications

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).1 Publication

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi177 – 1771Magnesium or manganese; catalyticBy similarity
Metal bindingi179 – 1791Magnesium or manganese; catalyticBy similarity

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • histone mRNA catabolic process Source: UniProtKB
  • mitotic nuclear division Source: UniProtKB-KW
  • mRNA processing Source: UniProtKB-KW
  • rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, mRNA processing, rRNA processing

Keywords - Ligandi

DNA-binding, Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BRENDAi2.7.7.19. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-canonical poly(A) RNA polymerase PAPD5 (EC:2.7.7.19)
Alternative name(s):
PAP-associated domain-containing protein 5
Terminal uridylyltransferase 3
Short name:
TUTase 3
Topoisomerase-related function protein 4-2
Short name:
TRF4-2
Gene namesi
Name:PAPD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:30758. PAPD5.

Subcellular locationi

  • Nucleus 2 Publications
  • Nucleusnucleolus 1 Publication
  • Cytoplasm 1 Publication

  • Note: Predominantly expressed in the cytoplasm (PubMed:18172165).

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949693.

Polymorphism and mutation databases

DMDMi59800139.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Non-canonical poly(A) RNA polymerase PAPD5PRO_0000120310Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei484 – 4841PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NDF8.
MaxQBiQ8NDF8.
PaxDbiQ8NDF8.
PRIDEiQ8NDF8.

PTM databases

iPTMnetiQ8NDF8.
PhosphoSiteiQ8NDF8.

Expressioni

Gene expression databases

CleanExiHS_PAPD5.
ExpressionAtlasiQ8NDF8. baseline and differential.
GenevisibleiQ8NDF8. HS.

Organism-specific databases

HPAiHPA042968.
HPA048225.

Interactioni

Subunit structurei

Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes.

Protein-protein interaction databases

BioGridi122126. 45 interactions.
DIPiDIP-59183N.
IntActiQ8NDF8. 2 interactions.
MINTiMINT-2824116.
STRINGi9606.ENSP00000396995.

Structurei

3D structure databases

ProteinModelPortaliQ8NDF8.
SMRiQ8NDF8. Positions 123-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini308 – 36861PAP-associatedAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi557 – 5637Basic, involved in binding of the RNA primer

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 325Poly-Asn
Compositional biasi45 – 7632Pro/Ser-richAdd
BLAST
Compositional biasi447 – 52579Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the DNA polymerase type-B-like family.Curated
Contains 1 PAP-associated domain.Curated

Phylogenomic databases

eggNOGiKOG1906. Eukaryota.
COG5260. LUCA.
GeneTreeiENSGT00400000022055.
HOGENOMiHOG000290646.
HOVERGENiHBG053489.
InParanoidiQ8NDF8.
KOiK03514.
OMAiHHQPGAW.
OrthoDBiEOG7X6KZP.
PhylomeDBiQ8NDF8.
TreeFamiTF313939.

Family and domain databases

InterProiIPR002058. PAP_assoc.
IPR002934. Polymerase_NTP_transf_dom.
[Graphical view]
PfamiPF01909. NTP_transf_2. 1 hit.
PF03828. PAP_assoc. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NDF8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYRSGERLLG SHALPAEQRD FLPLETTNNN NNHHQPGAWA RRAGSSASSP
60 70 80 90 100
PSASSSPHPS AAVPAADPAD SASGSSNKRK RDNKASGGRA AGGGRADGGG
110 120 130 140 150
VVYSGTPWKR RNYNQGVVGL HEEISDFYEY MSPRPEEEKM RMEVVNRIES
160 170 180 190 200
VIKELWPSAD VQIFGSFKTG LYLPTSDIDL VVFGKWENLP LWTLEEALRK
210 220 230 240 250
HKVADEDSVK VLDKATVPII KLTDSFTEVK VDISFNVQNG VRAADLIKDF
260 270 280 290 300
TKKYPVLPYL VLVLKQFLLQ RDLNEVFTGG IGSYSLFLMA VSFLQLHPRE
310 320 330 340 350
DACIPNTNYG VLLIEFFELY GRHFNYLKTG IRIKDGGSYV AKDEVQKNML
360 370 380 390 400
DGYRPSMLYI EDPLQPGNDV GRSSYGAMQV KQAFDYAYVV LSHAVSPIAK
410 420 430 440 450
YYPNNETESI LGRIIRVTDE VATYRDWISK QWGLKNRPEP SCNGPVSSSS
460 470 480 490 500
ATQSSSSDVD SDATPCKTPK QLLCRPSTGN RVGSQDVSLE SSQAVGKMQS
510 520 530 540 550
TQTTNTSNST NKSQHGSARL FRSSSKGFQG TTQTSHGSLM TNKQHQGKSN
560 570
NQYYHGKKRK HKRDAPLSDL CR
Length:572
Mass (Da):63,267
Last modified:February 1, 2005 - v2
Checksum:iD205C0DE961DA701
GO
Isoform 2 (identifier: Q8NDF8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-465: PVSSSSATQSSSSDVDSDATP → NETLHQVQCRPLLPHSPALVT
     466-572: Missing.

Note: No experimental confirmation available.
Show »
Length:465
Mass (Da):51,845
Checksum:i2C60D0E908CA56C4
GO
Isoform 3 (identifier: Q8NDF8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     444-444: G → GNGVTLIVDTQQLDKCNNNLSEENEALGKCRSKTSESLSKHSSNSSSG
     539-572: Missing.

Show »
Length:585
Mass (Da):64,197
Checksum:iD0322CF501EF428C
GO
Isoform 4 (identifier: Q8NDF8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-370: NDV → IEI
     371-572: Missing.

Note: No experimental confirmation available.
Show »
Length:370
Mass (Da):41,157
Checksum:i6452431129087203
GO
Isoform 5 (identifier: Q8NDF8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRPRPRSAPGKPRRRSRARLRSSRTPSGGASGGGGSSSSSSTATGGSGSSTGSPGGAASAPAPAPAGM
     85-85: A → ASTYGLNYSLLQP
     444-444: G → GNGVTLIVDTQQLDKCNNNLSEENEALGKCRSKTSESLSKHSSNSSSG

Show »
Length:698
Mass (Da):75,801
Checksum:iB35CF49F3E067CE6
GO

Sequence cautioni

The sequence AAD45199.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA91518.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MRPRPRSAPGKPRRRSRARL RSSRTPSGGASGGGGSSSSS STATGGSGSSTGSPGGAASA PAPAPAGM in isoform 5. 1 PublicationVSP_046989
Alternative sequencei85 – 851A → ASTYGLNYSLLQP in isoform 5. 1 PublicationVSP_046990
Alternative sequencei368 – 3703NDV → IEI in isoform 4. 1 PublicationVSP_012732
Alternative sequencei371 – 572202Missing in isoform 4. 1 PublicationVSP_012733Add
BLAST
Alternative sequencei444 – 4441G → GNGVTLIVDTQQLDKCNNNL SEENEALGKCRSKTSESLSK HSSNSSSG in isoform 3 and isoform 5. 2 PublicationsVSP_012735
Alternative sequencei445 – 46521PVSSS…SDATP → NETLHQVQCRPLLPHSPALV T in isoform 2. 1 PublicationVSP_012734Add
BLAST
Alternative sequencei466 – 572107Missing in isoform 2. 1 PublicationVSP_012736Add
BLAST
Alternative sequencei539 – 57234Missing in isoform 3. 1 PublicationVSP_012737Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001141 mRNA. Translation: BAA91518.1. Different initiation.
AK097589 mRNA. No translation available.
AK300918 mRNA. Translation: BAG62550.1.
AC007597 Genomic DNA. No translation available.
AC007610 Genomic DNA. No translation available.
AF089897 mRNA. Translation: AAD45199.1. Different initiation.
AL833922 mRNA. Translation: CAD38778.1.
CCDSiCCDS54006.1. [Q8NDF8-5]
RefSeqiNP_001035374.2. NM_001040284.2. [Q8NDF8-5]
NP_001035375.2. NM_001040285.2.
UniGeneiHs.514342.

Genome annotation databases

EnsembliENST00000436909; ENSP00000396995; ENSG00000121274. [Q8NDF8-5]
GeneIDi64282.
KEGGihsa:64282.
UCSCiuc010vgo.3. human. [Q8NDF8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001141 mRNA. Translation: BAA91518.1. Different initiation.
AK097589 mRNA. No translation available.
AK300918 mRNA. Translation: BAG62550.1.
AC007597 Genomic DNA. No translation available.
AC007610 Genomic DNA. No translation available.
AF089897 mRNA. Translation: AAD45199.1. Different initiation.
AL833922 mRNA. Translation: CAD38778.1.
CCDSiCCDS54006.1. [Q8NDF8-5]
RefSeqiNP_001035374.2. NM_001040284.2. [Q8NDF8-5]
NP_001035375.2. NM_001040285.2.
UniGeneiHs.514342.

3D structure databases

ProteinModelPortaliQ8NDF8.
SMRiQ8NDF8. Positions 123-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122126. 45 interactions.
DIPiDIP-59183N.
IntActiQ8NDF8. 2 interactions.
MINTiMINT-2824116.
STRINGi9606.ENSP00000396995.

PTM databases

iPTMnetiQ8NDF8.
PhosphoSiteiQ8NDF8.

Polymorphism and mutation databases

DMDMi59800139.

Proteomic databases

EPDiQ8NDF8.
MaxQBiQ8NDF8.
PaxDbiQ8NDF8.
PRIDEiQ8NDF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000436909; ENSP00000396995; ENSG00000121274. [Q8NDF8-5]
GeneIDi64282.
KEGGihsa:64282.
UCSCiuc010vgo.3. human. [Q8NDF8-1]

Organism-specific databases

CTDi64282.
GeneCardsiPAPD5.
HGNCiHGNC:30758. PAPD5.
HPAiHPA042968.
HPA048225.
MIMi605540. gene.
neXtProtiNX_Q8NDF8.
PharmGKBiPA134949693.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1906. Eukaryota.
COG5260. LUCA.
GeneTreeiENSGT00400000022055.
HOGENOMiHOG000290646.
HOVERGENiHBG053489.
InParanoidiQ8NDF8.
KOiK03514.
OMAiHHQPGAW.
OrthoDBiEOG7X6KZP.
PhylomeDBiQ8NDF8.
TreeFamiTF313939.

Enzyme and pathway databases

BRENDAi2.7.7.19. 2681.

Miscellaneous databases

ChiTaRSiPAPD5. human.
GenomeRNAii64282.
NextBioi66196.
PROiQ8NDF8.
SOURCEiSearch...

Gene expression databases

CleanExiHS_PAPD5.
ExpressionAtlasiQ8NDF8. baseline and differential.
GenevisibleiQ8NDF8. HS.

Family and domain databases

InterProiIPR002058. PAP_assoc.
IPR002934. Polymerase_NTP_transf_dom.
[Graphical view]
PfamiPF01909. NTP_transf_2. 1 hit.
PF03828. PAP_assoc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4 AND 5).
    Tissue: Embryo and Small intestine.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin."
    Walowsky C., Fitzhugh D.J., Castano I.B., Ju J.Y., Levin N.A., Christman M.F.
    J. Biol. Chem. 274:7302-7308(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 209-538 (ISOFORM 3), IDENTIFICATION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 163-572 (ISOFORM 1).
    Tissue: Testis.
  5. "Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'."
    Mullen T.E., Marzluff W.F.
    Genes Dev. 22:50-65(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN HISTONE MRNA DEGRADATION ACTIVITY, SUBCELLULAR LOCATION.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-484, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "PAPD5, a noncanonical poly(A) polymerase with an unusual RNA-binding motif."
    Rammelt C., Bilen B., Zavolan M., Keller W.
    RNA 17:1737-1746(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
  8. "Comparison of the yeast and human nuclear exosome complexes."
    Sloan K.E., Schneider C., Watkins N.J.
    Biochem. Soc. Trans. 40:850-855(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON RNA EXOSOMES.
  9. "Molecular cloning and characterization of a novel isoform of the non-canonical poly(A) polymerase PAPD7."
    Ogami K., Cho R., Hoshino S.
    Biochem. Biophys. Res. Commun. 432:135-140(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPAPD5_HUMAN
AccessioniPrimary (citable) accession number: Q8NDF8
Secondary accession number(s): B4DV38, Q9NW67, Q9Y6C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: May 11, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to have DNA polymerase activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.