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Protein

MORN repeat-containing protein 4

Gene

MORN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171160-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
MORN repeat-containing protein 4
Alternative name(s):
Protein 44050
Gene namesi
Name:MORN4
Synonyms:C10orf83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:24001. MORN4.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171160.
PharmGKBiPA162396074.

Polymorphism and mutation databases

BioMutaiMORN4.
DMDMi74751218.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794881 – 146MORN repeat-containing protein 4Add BLAST146

Proteomic databases

PaxDbiQ8NDC4.
PRIDEiQ8NDC4.

Expressioni

Gene expression databases

BgeeiENSG00000171160.
CleanExiHS_MORN4.
ExpressionAtlasiQ8NDC4. baseline and differential.
GenevisibleiQ8NDC4. HS.

Organism-specific databases

HPAiHPA052718.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BEND3Q5T5X73EBI-10269566,EBI-1211496
CRTAC1Q9NQ793EBI-10269566,EBI-10205543
FAM22FB7ZLH05EBI-10269566,EBI-10220102
HMMRO753303EBI-10269566,EBI-2556203
INO80EQ8NBZ03EBI-10269566,EBI-769401
NUTM1Q86Y263EBI-10269566,EBI-10178410
NYAP2Q9P2423EBI-10269566,EBI-10269689
SEPT6Q141413EBI-10269566,EBI-745901
SSX2IPQ9Y2D85EBI-10269566,EBI-2212028
TCF12Q990813EBI-10269566,EBI-722877
TCF4P158843EBI-10269566,EBI-533224
TRIM23P364065EBI-10269566,EBI-740098

Protein-protein interaction databases

BioGridi125622. 15 interactors.
IntActiQ8NDC4. 21 interactors.
MINTiMINT-4713791.
STRINGi9606.ENSP00000307636.

Structurei

3D structure databases

ProteinModelPortaliQ8NDC4.
SMRiQ8NDC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati16 – 38MORN 1Add BLAST23
Repeati39 – 61MORN 2Add BLAST23
Repeati62 – 84MORN 3Add BLAST23
Repeati85 – 107MORN 4Add BLAST23

Sequence similaritiesi

Contains 4 MORN repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0231. Eukaryota.
COG4642. LUCA.
GeneTreeiENSGT00730000111173.
HOGENOMiHOG000000688.
HOVERGENiHBG054330.
InParanoidiQ8NDC4.
OMAiKREKCPG.
OrthoDBiEOG091G0WNQ.
PhylomeDBiQ8NDC4.
TreeFamiTF323893.

Family and domain databases

InterProiIPR003409. MORN.
[Graphical view]
PfamiPF02493. MORN. 4 hits.
[Graphical view]
SMARTiSM00698. MORN. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NDC4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLTKGSFTY SSGEEYRGEW KEGRRHGFGQ LMFADGGTYL GHFENGLFNG
60 70 80 90 100
FGVLTFSDGS RYEGEFAQGK FNGVGVFIRY DNMTFEGEFK NGRVDGFGLL
110 120 130 140
TFPDGSHGIP RNEGLFENNK LLRREKCSAI VQRAQSASKS ARNLTA
Length:146
Mass (Da):16,236
Last modified:October 1, 2002 - v1
Checksum:i4DCF6DAD95100D1C
GO
Isoform 2 (identifier: Q8NDC4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MTLTKGSFTYSSGEEYRGEWKE → MAWSRAGPMR...RDGHPERPAP

Show »
Length:204
Mass (Da):22,669
Checksum:i09AFC8E23C684AC7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0234571 – 22MTLTK…GEWKE → MAWSRAGPMRSGVAPGCLGN SQWAAGIVPSAVAQDGGVKW GNRWWRWRRARWQPGAHQRK SPRRWNPASRRDGHPERPAP in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ431726 mRNA. Translation: CAD24475.1.
AJ312050 mRNA. Translation: CAC85055.1.
AL834132 mRNA. Translation: CAD38849.1.
AL355315 Genomic DNA. Translation: CAI15459.1.
BC093023 mRNA. Translation: AAH93023.1.
BC010230 mRNA. Translation: AAH10230.1.
BC040015 mRNA. Translation: AAH40015.1.
CCDSiCCDS7468.1. [Q8NDC4-1]
RefSeqiNP_001092301.1. NM_001098831.1. [Q8NDC4-1]
NP_849154.1. NM_178832.3. [Q8NDC4-1]
XP_011537552.1. XM_011539250.2. [Q8NDC4-2]
XP_011537553.1. XM_011539251.2. [Q8NDC4-1]
UniGeneiHs.217409.

Genome annotation databases

EnsembliENST00000307450; ENSP00000307636; ENSG00000171160. [Q8NDC4-1]
GeneIDi118812.
KEGGihsa:118812.
UCSCiuc001kob.5. human. [Q8NDC4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ431726 mRNA. Translation: CAD24475.1.
AJ312050 mRNA. Translation: CAC85055.1.
AL834132 mRNA. Translation: CAD38849.1.
AL355315 Genomic DNA. Translation: CAI15459.1.
BC093023 mRNA. Translation: AAH93023.1.
BC010230 mRNA. Translation: AAH10230.1.
BC040015 mRNA. Translation: AAH40015.1.
CCDSiCCDS7468.1. [Q8NDC4-1]
RefSeqiNP_001092301.1. NM_001098831.1. [Q8NDC4-1]
NP_849154.1. NM_178832.3. [Q8NDC4-1]
XP_011537552.1. XM_011539250.2. [Q8NDC4-2]
XP_011537553.1. XM_011539251.2. [Q8NDC4-1]
UniGeneiHs.217409.

3D structure databases

ProteinModelPortaliQ8NDC4.
SMRiQ8NDC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125622. 15 interactors.
IntActiQ8NDC4. 21 interactors.
MINTiMINT-4713791.
STRINGi9606.ENSP00000307636.

Polymorphism and mutation databases

BioMutaiMORN4.
DMDMi74751218.

Proteomic databases

PaxDbiQ8NDC4.
PRIDEiQ8NDC4.

Protocols and materials databases

DNASUi118812.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307450; ENSP00000307636; ENSG00000171160. [Q8NDC4-1]
GeneIDi118812.
KEGGihsa:118812.
UCSCiuc001kob.5. human. [Q8NDC4-1]

Organism-specific databases

CTDi118812.
GeneCardsiMORN4.
HGNCiHGNC:24001. MORN4.
HPAiHPA052718.
neXtProtiNX_Q8NDC4.
OpenTargetsiENSG00000171160.
PharmGKBiPA162396074.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0231. Eukaryota.
COG4642. LUCA.
GeneTreeiENSGT00730000111173.
HOGENOMiHOG000000688.
HOVERGENiHBG054330.
InParanoidiQ8NDC4.
OMAiKREKCPG.
OrthoDBiEOG091G0WNQ.
PhylomeDBiQ8NDC4.
TreeFamiTF323893.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171160-MONOMER.

Miscellaneous databases

GenomeRNAii118812.
PROiQ8NDC4.

Gene expression databases

BgeeiENSG00000171160.
CleanExiHS_MORN4.
ExpressionAtlasiQ8NDC4. baseline and differential.
GenevisibleiQ8NDC4. HS.

Family and domain databases

InterProiIPR003409. MORN.
[Graphical view]
PfamiPF02493. MORN. 4 hits.
[Graphical view]
SMARTiSM00698. MORN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMORN4_HUMAN
AccessioniPrimary (citable) accession number: Q8NDC4
Secondary accession number(s): Q86Y54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.