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Protein

MORN repeat-containing protein 4

Gene

MORN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
MORN repeat-containing protein 4
Alternative name(s):
Protein 44050
Retinophilin1 Publication
Gene namesi
Name:MORN4
Synonyms:C10orf83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000171160.17.
HGNCiHGNC:24001. MORN4.

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi118812.
OpenTargetsiENSG00000171160.
PharmGKBiPA162396074.

Polymorphism and mutation databases

BioMutaiMORN4.
DMDMi74751218.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794881 – 146MORN repeat-containing protein 4Add BLAST146

Proteomic databases

PaxDbiQ8NDC4.
PeptideAtlasiQ8NDC4.
PRIDEiQ8NDC4.

Expressioni

Gene expression databases

BgeeiENSG00000171160.
CleanExiHS_MORN4.
ExpressionAtlasiQ8NDC4. baseline and differential.
GenevisibleiQ8NDC4. HS.

Organism-specific databases

HPAiHPA052718.

Interactioni

Subunit structurei

Interacts with MYO3A.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125622. 18 interactors.
IntActiQ8NDC4. 21 interactors.
MINTiMINT-4713791.
STRINGi9606.ENSP00000307636.

Structurei

3D structure databases

ProteinModelPortaliQ8NDC4.
SMRiQ8NDC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati16 – 38MORN 1Add BLAST23
Repeati39 – 61MORN 2Add BLAST23
Repeati62 – 84MORN 3Add BLAST23
Repeati85 – 107MORN 4Add BLAST23

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0231. Eukaryota.
COG4642. LUCA.
GeneTreeiENSGT00730000111173.
HOGENOMiHOG000000688.
HOVERGENiHBG054330.
InParanoidiQ8NDC4.
OMAiHGVPRNE.
OrthoDBiEOG091G0WNQ.
PhylomeDBiQ8NDC4.
TreeFamiTF323893.

Family and domain databases

InterProiView protein in InterPro
IPR003409. MORN.
PfamiView protein in Pfam
PF02493. MORN. 4 hits.
SMARTiView protein in SMART
SM00698. MORN. 4 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NDC4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLTKGSFTY SSGEEYRGEW KEGRRHGFGQ LMFADGGTYL GHFENGLFNG
60 70 80 90 100
FGVLTFSDGS RYEGEFAQGK FNGVGVFIRY DNMTFEGEFK NGRVDGFGLL
110 120 130 140
TFPDGSHGIP RNEGLFENNK LLRREKCSAI VQRAQSASKS ARNLTA
Length:146
Mass (Da):16,236
Last modified:October 1, 2002 - v1
Checksum:i4DCF6DAD95100D1C
GO
Isoform 2 (identifier: Q8NDC4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MTLTKGSFTYSSGEEYRGEWKE → MAWSRAGPMR...RDGHPERPAP

Show »
Length:204
Mass (Da):22,669
Checksum:i09AFC8E23C684AC7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0234571 – 22MTLTK…GEWKE → MAWSRAGPMRSGVAPGCLGN SQWAAGIVPSAVAQDGGVKW GNRWWRWRRARWQPGAHQRK SPRRWNPASRRDGHPERPAP in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ431726 mRNA. Translation: CAD24475.1.
AJ312050 mRNA. Translation: CAC85055.1.
AL834132 mRNA. Translation: CAD38849.1.
AL355315 Genomic DNA. Translation: CAI15459.1.
BC093023 mRNA. Translation: AAH93023.1.
BC010230 mRNA. Translation: AAH10230.1.
BC040015 mRNA. Translation: AAH40015.1.
CCDSiCCDS7468.1. [Q8NDC4-1]
RefSeqiNP_001092301.1. NM_001098831.1. [Q8NDC4-1]
NP_849154.1. NM_178832.3. [Q8NDC4-1]
XP_011537552.1. XM_011539250.2. [Q8NDC4-2]
XP_011537553.1. XM_011539251.2. [Q8NDC4-1]
UniGeneiHs.217409.

Genome annotation databases

EnsembliENST00000307450; ENSP00000307636; ENSG00000171160. [Q8NDC4-1]
GeneIDi118812.
KEGGihsa:118812.
UCSCiuc001kob.5. human. [Q8NDC4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMORN4_HUMAN
AccessioniPrimary (citable) accession number: Q8NDC4
Secondary accession number(s): Q86Y54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM