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Protein

MAPK-interacting and spindle-stabilizing protein-like

Gene

MAPK1IP1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
MAPK-interacting and spindle-stabilizing protein-like
Alternative name(s):
Mitogen-activated protein kinase 1-interacting protein 1-like
Gene namesi
Name:MAPK1IP1L
Synonyms:C14orf32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19840. MAPK1IP1L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162395015.

Polymorphism and mutation databases

BioMutaiMAPK1IP1L.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources1 Publication
Chaini2 – 245244MAPK-interacting and spindle-stabilizing protein-likePRO_0000209890Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources1 Publication
Modified residuei2 – 21PhosphoserineCombined sources
Modified residuei6 – 61PhosphoserineCombined sources
Modified residuei15 – 151PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8NDC0.
MaxQBiQ8NDC0.
PaxDbiQ8NDC0.
PeptideAtlasiQ8NDC0.
PRIDEiQ8NDC0.

PTM databases

iPTMnetiQ8NDC0.
PhosphoSiteiQ8NDC0.

Expressioni

Gene expression databases

BgeeiENSG00000168175.
CleanExiHS_MAPK1IP1L.
GenevisibleiQ8NDC0. HS.

Organism-specific databases

HPAiHPA034506.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
G2XKQ03EBI-741424,EBI-10175576
ARHGEF16Q5VV413EBI-741424,EBI-1057448
C1orf94Q6P1W54EBI-741424,EBI-946029
CEP55D3DR373EBI-741424,EBI-10173536
EWSR1Q018445EBI-741424,EBI-739737
HGSO149643EBI-741424,EBI-740220
HNRNPUL1Q9BUJ25EBI-741424,EBI-1018153
RBFOX2O432513EBI-741424,EBI-746056
SS18L1O751773EBI-741424,EBI-744674
SUMO1P631653EBI-741424,EBI-80140
TFGQ927343EBI-741424,EBI-357061
UBE2IQ7KZS03EBI-741424,EBI-10180829
VPS37CA5D8V63EBI-741424,EBI-2559305

Protein-protein interaction databases

BioGridi125030. 19 interactions.
IntActiQ8NDC0. 19 interactions.
MINTiMINT-1438528.
STRINGi9606.ENSP00000378851.

Structurei

3D structure databases

ProteinModelPortaliQ8NDC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 241215Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the MISS family.Curated

Phylogenomic databases

eggNOGiENOG410IX7N. Eukaryota.
ENOG4111CPI. LUCA.
GeneTreeiENSGT00730000111340.
HOGENOMiHOG000059660.
HOVERGENiHBG039557.
InParanoidiQ8NDC0.
OMAiRFLFRRQ.
OrthoDBiEOG091G15C3.
PhylomeDBiQ8NDC0.

Family and domain databases

InterProiIPR031653. MISS.
[Graphical view]
PfamiPF15822. MISS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NDC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDEFSLADA LPEHSPAKTS AVSNTKPGQP PQGWPGSNPW NNPSAPSSVP
60 70 80 90 100
SGLPPSATPS TVPFGPAPTG MYPSVPPTGP PPGPPAPFPP SGPSCPPPGG
110 120 130 140 150
PYPAPTVPGP GPTGPYPTPN MPFPELPRPY GAPTDPAAAG PLGPWGSMSS
160 170 180 190 200
GPWAPGMGGQ YPTPNMPYPS PGPYPAPPPP QAPGAAPPVP WGTVPPGAWG
210 220 230 240
PPAPYPAPTG SYPTPGLYPT PSNPFQVPSG PSGAPPMPGG PHSYH
Length:245
Mass (Da):24,269
Last modified:January 23, 2007 - v4
Checksum:i8B03ADFE2581D5C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315501 mRNA. Translation: BAG37885.1.
AL834285 mRNA. Translation: CAD38959.2.
AL139316 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80657.1.
BC015621 mRNA. Translation: AAH15621.1.
CCDSiCCDS32085.1.
RefSeqiNP_653179.1. NM_144578.3.
UniGeneiHs.594338.

Genome annotation databases

EnsembliENST00000395468; ENSP00000378851; ENSG00000168175.
ENST00000622254; ENSP00000481882; ENSG00000168175.
GeneIDi93487.
KEGGihsa:93487.
UCSCiuc001xbq.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315501 mRNA. Translation: BAG37885.1.
AL834285 mRNA. Translation: CAD38959.2.
AL139316 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80657.1.
BC015621 mRNA. Translation: AAH15621.1.
CCDSiCCDS32085.1.
RefSeqiNP_653179.1. NM_144578.3.
UniGeneiHs.594338.

3D structure databases

ProteinModelPortaliQ8NDC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125030. 19 interactions.
IntActiQ8NDC0. 19 interactions.
MINTiMINT-1438528.
STRINGi9606.ENSP00000378851.

PTM databases

iPTMnetiQ8NDC0.
PhosphoSiteiQ8NDC0.

Polymorphism and mutation databases

BioMutaiMAPK1IP1L.

Proteomic databases

EPDiQ8NDC0.
MaxQBiQ8NDC0.
PaxDbiQ8NDC0.
PeptideAtlasiQ8NDC0.
PRIDEiQ8NDC0.

Protocols and materials databases

DNASUi93487.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395468; ENSP00000378851; ENSG00000168175.
ENST00000622254; ENSP00000481882; ENSG00000168175.
GeneIDi93487.
KEGGihsa:93487.
UCSCiuc001xbq.2. human.

Organism-specific databases

CTDi93487.
GeneCardsiMAPK1IP1L.
HGNCiHGNC:19840. MAPK1IP1L.
HPAiHPA034506.
neXtProtiNX_Q8NDC0.
PharmGKBiPA162395015.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX7N. Eukaryota.
ENOG4111CPI. LUCA.
GeneTreeiENSGT00730000111340.
HOGENOMiHOG000059660.
HOVERGENiHBG039557.
InParanoidiQ8NDC0.
OMAiRFLFRRQ.
OrthoDBiEOG091G15C3.
PhylomeDBiQ8NDC0.

Miscellaneous databases

ChiTaRSiMAPK1IP1L. human.
GeneWikiiC14orf32.
GenomeRNAii93487.
PROiQ8NDC0.

Gene expression databases

BgeeiENSG00000168175.
CleanExiHS_MAPK1IP1L.
GenevisibleiQ8NDC0. HS.

Family and domain databases

InterProiIPR031653. MISS.
[Graphical view]
PfamiPF15822. MISS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMISSL_HUMAN
AccessioniPrimary (citable) accession number: Q8NDC0
Secondary accession number(s): B2RDD8, Q96BG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 105 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.