Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8NDC0

- MISSL_HUMAN

UniProt

Q8NDC0 - MISSL_HUMAN

Protein

MAPK-interacting and spindle-stabilizing protein-like

Gene

MAPK1IP1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MAPK-interacting and spindle-stabilizing protein-like
    Alternative name(s):
    Mitogen-activated protein kinase 1-interacting protein 1-like
    Gene namesi
    Name:MAPK1IP1L
    Synonyms:C14orf32
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:19840. MAPK1IP1L.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162395015.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed4 Publications
    Chaini2 – 245244MAPK-interacting and spindle-stabilizing protein-likePRO_0000209890Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine4 Publications
    Modified residuei15 – 151Phosphoserine4 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8NDC0.
    PaxDbiQ8NDC0.
    PRIDEiQ8NDC0.

    PTM databases

    PhosphoSiteiQ8NDC0.

    Expressioni

    Gene expression databases

    BgeeiQ8NDC0.
    CleanExiHS_MAPK1IP1L.
    GenevestigatoriQ8NDC0.

    Organism-specific databases

    HPAiHPA034506.

    Interactioni

    Protein-protein interaction databases

    BioGridi125030. 7 interactions.
    IntActiQ8NDC0. 6 interactions.
    MINTiMINT-1438528.
    STRINGi9606.ENSP00000378851.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NDC0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi27 – 241215Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MISS family.Curated

    Phylogenomic databases

    eggNOGiNOG25555.
    HOGENOMiHOG000059660.
    HOVERGENiHBG039557.
    InParanoidiQ8NDC0.
    OMAiRIEALLX.
    OrthoDBiEOG7Q8CR3.
    PhylomeDBiQ8NDC0.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8NDC0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDEFSLADA LPEHSPAKTS AVSNTKPGQP PQGWPGSNPW NNPSAPSSVP    50
    SGLPPSATPS TVPFGPAPTG MYPSVPPTGP PPGPPAPFPP SGPSCPPPGG 100
    PYPAPTVPGP GPTGPYPTPN MPFPELPRPY GAPTDPAAAG PLGPWGSMSS 150
    GPWAPGMGGQ YPTPNMPYPS PGPYPAPPPP QAPGAAPPVP WGTVPPGAWG 200
    PPAPYPAPTG SYPTPGLYPT PSNPFQVPSG PSGAPPMPGG PHSYH 245
    Length:245
    Mass (Da):24,269
    Last modified:January 23, 2007 - v4
    Checksum:i8B03ADFE2581D5C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK315501 mRNA. Translation: BAG37885.1.
    AL834285 mRNA. Translation: CAD38959.2.
    AL139316 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW80657.1.
    BC015621 mRNA. Translation: AAH15621.1.
    CCDSiCCDS32085.1.
    RefSeqiNP_653179.1. NM_144578.3.
    UniGeneiHs.594338.

    Genome annotation databases

    EnsembliENST00000395468; ENSP00000378851; ENSG00000168175.
    GeneIDi93487.
    KEGGihsa:93487.
    UCSCiuc001xbq.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK315501 mRNA. Translation: BAG37885.1 .
    AL834285 mRNA. Translation: CAD38959.2 .
    AL139316 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW80657.1 .
    BC015621 mRNA. Translation: AAH15621.1 .
    CCDSi CCDS32085.1.
    RefSeqi NP_653179.1. NM_144578.3.
    UniGenei Hs.594338.

    3D structure databases

    ProteinModelPortali Q8NDC0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125030. 7 interactions.
    IntActi Q8NDC0. 6 interactions.
    MINTi MINT-1438528.
    STRINGi 9606.ENSP00000378851.

    PTM databases

    PhosphoSitei Q8NDC0.

    Proteomic databases

    MaxQBi Q8NDC0.
    PaxDbi Q8NDC0.
    PRIDEi Q8NDC0.

    Protocols and materials databases

    DNASUi 93487.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395468 ; ENSP00000378851 ; ENSG00000168175 .
    GeneIDi 93487.
    KEGGi hsa:93487.
    UCSCi uc001xbq.1. human.

    Organism-specific databases

    CTDi 93487.
    GeneCardsi GC14P055518.
    HGNCi HGNC:19840. MAPK1IP1L.
    HPAi HPA034506.
    neXtProti NX_Q8NDC0.
    PharmGKBi PA162395015.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25555.
    HOGENOMi HOG000059660.
    HOVERGENi HBG039557.
    InParanoidi Q8NDC0.
    OMAi RIEALLX.
    OrthoDBi EOG7Q8CR3.
    PhylomeDBi Q8NDC0.

    Miscellaneous databases

    ChiTaRSi MAPK1IP1L. human.
    GeneWikii C14orf32.
    GenomeRNAii 93487.
    NextBioi 78100.
    PROi Q8NDC0.

    Gene expression databases

    Bgeei Q8NDC0.
    CleanExi HS_MAPK1IP1L.
    Genevestigatori Q8NDC0.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    6. Bienvenut W.V., Kanor S., Tissot J.-D., Quadroni M.
      Submitted (MAY-2006) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-17, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: T-cell.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMISSL_HUMAN
    AccessioniPrimary (citable) accession number: Q8NDC0
    Secondary accession number(s): B2RDD8, Q96BG5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 88 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3