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Q8NDA8 (MROH1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Maestro heat-like repeat-containing protein family member 1
Alternative name(s):
HEAT repeat-containing protein 7A
Gene names
Name:MROH1
Synonyms:HEATR7A, KIAA1833
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1641 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 7 HEAT repeats.

Sequence caution

The sequence AAH57824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAH67855.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAH92486.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAB47462.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence CAD38979.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NDA8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NDA8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     774-782: Missing.
     1143-1156: SHTCMLWRALAVEP → RYPAQTPGLGVPLE
     1157-1641: Missing.
Isoform 3 (identifier: Q8NDA8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1038: Missing.
     1039-1040: GQ → MR
     1593-1641: FLVLHSEPRQ...EALGRLVKLA → KHHPLPHPHA...PGPRGADEGC
Isoform 4 (identifier: Q8NDA8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     381-422: AAQMEDKKPF...VISAMAHHGY → GSTNTRITLM...DLTAAPASVA
     423-1641: Missing.
Isoform 5 (identifier: Q8NDA8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     317-378: ICVPVESSSP...TLQVVRHVIN → VGGGRQGAGP...AMWRCSCPAQ
     379-1641: Missing.
Isoform 6 (identifier: Q8NDA8-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
     381-408: AAQMEDKKPFILSSMRLPLLDTNSKVKR → GECLHASLAATPGHVQDGAGPGRLCPSK
     409-1641: Missing.
Isoform 7 (identifier: Q8NDA8-7)

The sequence of this isoform differs from the canonical sequence as follows:
     592-610: EHTEETLPQEEWEEKLLMF → GEARVRMGCIALWGGQVSE
     611-1641: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16411641Maestro heat-like repeat-containing protein family member 1
PRO_0000329402

Regions

Repeat3 – 4139HEAT 1
Repeat159 – 19840HEAT 2
Repeat344 – 38239HEAT 3
Repeat385 – 42339HEAT 4
Repeat1048 – 108639HEAT 5
Repeat1358 – 139639HEAT 6
Repeat1605 – 164137HEAT 7

Natural variations

Alternative sequence1 – 10381038Missing in isoform 3.
VSP_032963
Alternative sequence1 – 6868Missing in isoform 6.
VSP_032965
Alternative sequence317 – 37862ICVPV…RHVIN → VGGGRQGAGPGSAHPSVGSC WTRGAESKLGWMAQPRGAED WAFPEGHSGDFLAMWRCSCP AQ in isoform 5.
VSP_032966
Alternative sequence379 – 16411263Missing in isoform 5.
VSP_032967
Alternative sequence381 – 42242AAQME…AHHGY → GSTNTRITLMLPSAVTRLKH EDCPARAAPQPADLTAAPAS VA in isoform 4.
VSP_032968
Alternative sequence381 – 40828AAQME…SKVKR → GECLHASLAATPGHVQDGAG PGRLCPSK in isoform 6.
VSP_032969
Alternative sequence409 – 16411233Missing in isoform 6.
VSP_032970
Alternative sequence423 – 16411219Missing in isoform 4.
VSP_032971
Alternative sequence592 – 61019EHTEE…KLLMF → GEARVRMGCIALWGGQVSE in isoform 7.
VSP_032972
Alternative sequence611 – 16411031Missing in isoform 7.
VSP_032973
Alternative sequence774 – 7829Missing in isoform 2.
VSP_032974
Alternative sequence1039 – 10402GQ → MR in isoform 3.
VSP_032975
Alternative sequence1143 – 115614SHTCM…LAVEP → RYPAQTPGLGVPLE in isoform 2.
VSP_032976
Alternative sequence1157 – 1641485Missing in isoform 2.
VSP_032977
Alternative sequence1593 – 164149FLVLH…LVKLA → KHHPLPHPHAARQPRLMPPL HRVPGAALGAQAAAAGGPGP AHCGAPDPAEGPGPRGADEG C in isoform 3.
VSP_032978
Natural variant381A → V. Ref.1 Ref.2 Ref.3 Ref.5 Ref.6
Corresponds to variant rs34819224 [ dbSNP | Ensembl ].
VAR_062166

Experimental info

Sequence conflict701E → K in AK093563. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: FD194A308C021254

FASTA1,641181,249
        10         20         30         40         50         60 
MTESSMKKLA STLLDAITDK DPLVQEQVCS ALCSLGEARP VETLRACEEY LRQHDKLAHP 

        70         80         90        100        110        120 
YRAAVLRAME RVLSSRASEL DKDTASTIIL LASSEMTKTK DLVWDWQQAA SGVLVAVGRQ 

       130        140        150        160        170        180 
FISKVMEELL RRLHPGTLPH CAVLHTLASL SVANAFGVVP FLPSVLSSLL PVLGVAKQDT 

       190        200        210        220        230        240 
VRVAFCSALQ RFSEGALEYL ANLDRAPDPT VRKDAFATDI FSAYDVLFHQ WLQSREAKLR 

       250        260        270        280        290        300 
LAVVEALGPM SHLLPSERLE EQLPKLLPGI LALYKKHAET FYLSKSLGQI LEAAVSVGSR 

       310        320        330        340        350        360 
TLETQLDALL AALHSQICVP VESSSPLVMS NQKEVLRCFT VLACSSPDRL LAFLLPRLDT 

       370        380        390        400        410        420 
SNERTRVGTL QVVRHVINSA AAQMEDKKPF ILSSMRLPLL DTNSKVKRAV VQVISAMAHH 

       430        440        450        460        470        480 
GYLEQPGGEA MIEYIVQQCA LPPEQEPEKP GPGSKDPKAD SVRAISVRTL YLVSTTVDRM 

       490        500        510        520        530        540 
SHVLWPYLLQ FLTPVRFTGA LTPLCRSLVH LAQKRQEAGA DAFLIQYDAH ASLPSPYAVT 

       550        560        570        580        590        600 
GRLLVVSSSP YLGDGRGAAA LRLLSVLHPN IHPLLGQHWE TTVPLLLGYL DEHTEETLPQ 

       610        620        630        640        650        660 
EEWEEKLLMF LRDTLAIISD NAWICQLSLE LCRQLPCYDE APQEKNFLYK CIGTTLGAAS 

       670        680        690        700        710        720 
SKEVVRKHLQ ELLETARYQE EAEREGLACC FGICAISHLE DTLAQLEDFV RSEVFRKSIG 

       730        740        750        760        770        780 
ILNIFKDRSE NEVEKVKSAL ILCYGHVAAR APRELVLAKV ESDILRNICQ HFSTKVLGIK 

       790        800        810        820        830        840 
VETKDPALKL CLVQSVCMVS RAICSSTQAG SFHFTRKAEL VAQMMEFIRA EPPDSLRTPI 

       850        860        870        880        890        900 
RKKAMLTCTY LVSVEPALDE QARADVIHGC LHSIMALLPE PKEEDGGCQK SLYLETLHAL 

       910        920        930        940        950        960 
EDLLTSLLQR NMTPQGLQIM IEHLSPWIKS PRGHERARAL GLSALLLRYF LEHLRVSALV 

       970        980        990       1000       1010       1020 
PFHNLGLLIG LFSPRCADLW PATRQEAVDC VYSLLYLQLG YEGFSRDYRD DVAERLLSLK 

      1030       1040       1050       1060       1070       1080 
DGLVHPDPAI LFHTCHSVGQ IIAKRLPPDQ LISLLLTMFE ALGDPEKNCS RAATVMINCL 

      1090       1100       1110       1120       1130       1140 
LQERGGVLQE KVPEIVSVLR SKLQEAQGEH VLPAAQHSVY LLATQHCAAV VSSLLGSPLP 

      1150       1160       1170       1180       1190       1200 
LDSHTCMLWR ALAVEPRLAA QVLGLLLEKM SRDVPFKESR AFLLGRTPDR VATLLPLSAT 

      1210       1220       1230       1240       1250       1260 
CALFEVMSTP AAGPAVLELY PQLFVVLLLR VSCTVGVQLP RNLQAQERRG ASPALATRNL 

      1270       1280       1290       1300       1310       1320 
EPCSSAVDTL RSMLLRSGSE DVVQRMDLEG GWELLRTSAG HEEGATRLAR AMAEHAGPRL 

      1330       1340       1350       1360       1370       1380 
PLVLKTLACT HSSAYENQRV TTTAFLAELL NSNVANDLML LDSLLESLAA RQKDTCASVR 

      1390       1400       1410       1420       1430       1440 
RLVLRGLANL ASGCPDKVRT HGPQLLTAMI GGLDDGDNPH SPVALEAMLG LARLVHLVES 

      1450       1460       1470       1480       1490       1500 
WDLRSGLLHV AIRIRPFFDS EKMEFRTASI RLFGHLNKVC HGDCEDVFLD QVVGGLAPLL 

      1510       1520       1530       1540       1550       1560 
LHLQDPQATV ASACRFALRM CGPNLACEEL SAAFQKHLQE GRALHFGEFL NTTCKHLMHH 

      1570       1580       1590       1600       1610       1620 
FPDLLGRLLT TCLFYFKSSW ENVRAAAPLF TGFLVLHSEP RQQPQVDLDQ LIAALQILLK 

      1630       1640 
DPAPEVRTRA AEALGRLVKL A 

« Hide

Isoform 2 [UniParc].

Checksum: 87F01077DC188B9E
Show »

FASTA1,147127,078
Isoform 3 [UniParc].

Checksum: F6330DAF247461C6
Show »

FASTA61566,506
Isoform 4 [UniParc].

Checksum: AB73844C342F523F
Show »

FASTA42246,043
Isoform 5 [UniParc].

Checksum: A7A6F681D2B5145C
Show »

FASTA37841,137
Isoform 6 [UniParc].

Checksum: 0065E6D4F1B7BD14
Show »

FASTA34036,918
Isoform 7 [UniParc].

Checksum: 7D2B88D7EAEF6BA1
Show »

FASTA61066,868

References

[1]"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-38.
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 384-1641 (ISOFORM 7), VARIANT VAL-38.
Tissue: Spleen and Thymus.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT VAL-38.
Tissue: Testis.
[4]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-38.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 6), VARIANT VAL-38.
Tissue: Blood and Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB058736 mRNA. Translation: BAB47462.1. Different initiation.
AK092861 mRNA. No translation available.
AK093563 mRNA. No translation available.
AL834309 mRNA. Translation: CAD38979.1. Different initiation.
AL834145 mRNA. Translation: CAD38858.1.
AC104592 Genomic DNA. No translation available.
AC145291 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82134.1.
CH471162 Genomic DNA. Translation: EAW82137.1.
CH471162 Genomic DNA. Translation: EAW82143.1.
BC040742 mRNA. Translation: AAH40742.1.
BC092486 mRNA. Translation: AAH92486.1. Different initiation.
BC057824 mRNA. Translation: AAH57824.1. Different initiation.
BC067855 mRNA. Translation: AAH67855.1. Different initiation.
CCDSCCDS47938.1. [Q8NDA8-1]
CCDS47939.1. [Q8NDA8-4]
RefSeqNP_001092750.1. NM_001099280.2.
NP_001092751.1. NM_001099281.2.
NP_001275743.1. NM_001288814.1.
NP_115826.2. NM_032450.2.
XP_006716699.1. XM_006716636.1. [Q8NDA8-2]
UniGeneHs.443139.

3D structure databases

ProteinModelPortalQ8NDA8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid608397. 2 interactions.

PTM databases

PhosphoSiteQ8NDA8.

Polymorphism databases

DMDM296439329.

Proteomic databases

MaxQBQ8NDA8.
PaxDbQ8NDA8.
PRIDEQ8NDA8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000326134; ENSP00000321737; ENSG00000179832. [Q8NDA8-1]
ENST00000398656; ENSP00000381649; ENSG00000179832. [Q8NDA8-1]
ENST00000423230; ENSP00000388174; ENSG00000179832. [Q8NDA8-4]
ENST00000528919; ENSP00000435565; ENSG00000179832. [Q8NDA8-1]
ENST00000544576; ENSP00000437866; ENSG00000179832. [Q8NDA8-3]
ENST00000562181; ENSP00000454801; ENSG00000260383. [Q8NDA8-4]
ENST00000568089; ENSP00000455272; ENSG00000260383. [Q8NDA8-1]
GeneID727957.
KEGGhsa:727957.
UCSCuc003zbg.2. human. [Q8NDA8-5]
uc003zbh.4. human. [Q8NDA8-4]
uc003zbk.4. human. [Q8NDA8-1]
uc003zbl.4. human. [Q8NDA8-3]
uc011lla.1. human. [Q8NDA8-2]

Organism-specific databases

CTD727957.
GeneCardsGC08P145203.
H-InvDBHIX0188658.
HGNCHGNC:26958. MROH1.
HPAHPA044465.
neXtProtNX_Q8NDA8.
PharmGKBPA164720350.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG291078.
HOVERGENHBG107983.
InParanoidQ8NDA8.
OMAPRCIDSN.
PhylomeDBQ8NDA8.
TreeFamTF315201.

Gene expression databases

ArrayExpressQ8NDA8.
BgeeQ8NDA8.
CleanExHS_HEATR7A.
GenevestigatorQ8NDA8.

Family and domain databases

Gene3D1.25.10.10. 6 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR021133. HEAT_type_2.
[Graphical view]
PfamPF02985. HEAT. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 8 hits.
PROSITEPS50077. HEAT_REPEAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHEATR7A. human.
GenomeRNAi727957.
NextBio125683.
PROQ8NDA8.

Entry information

Entry nameMROH1_HUMAN
AccessionPrimary (citable) accession number: Q8NDA8
Secondary accession number(s): C9JWM5 expand/collapse secondary AC list , D3DWL5, Q0P612, Q569G6, Q6NVW4, Q8N230, Q8NAD1, Q8ND95, Q96JJ4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM