Q8NDA8 (MROH1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Maestro heat-like repeat-containing protein family member 1

Alternative name(s):
HEAT repeat-containing protein 7A

Gene names

Name:	MROH1
Synonyms:	HEATR7A, KIAA1833

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1641 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 7 HEAT repeats.

Sequence caution

The sequence AAH57824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAH67855.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAH92486.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAB47462.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAD38979.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NDA8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NDA8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     774-782: Missing.
     1143-1156: SHTCMLWRALAVEP → RYPAQTPGLGVPLE
     1157-1641: Missing.

Isoform 3 (identifier: Q8NDA8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1038: Missing.
     1039-1040: GQ → MR
     1593-1641: FLVLHSEPRQ...EALGRLVKLA → KHHPLPHPHA...PGPRGADEGC

Isoform 4 (identifier: Q8NDA8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     381-422: AAQMEDKKPF...VISAMAHHGY → GSTNTRITLM...DLTAAPASVA
     423-1641: Missing.

Isoform 5 (identifier: Q8NDA8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     317-378: ICVPVESSSP...TLQVVRHVIN → VGGGRQGAGP...AMWRCSCPAQ
     379-1641: Missing.

Isoform 6 (identifier: Q8NDA8-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
     381-408: AAQMEDKKPFILSSMRLPLLDTNSKVKR → GECLHASLAATPGHVQDGAGPGRLCPSK
     409-1641: Missing.

Isoform 7 (identifier: Q8NDA8-7)

The sequence of this isoform differs from the canonical sequence as follows:
     592-610: EHTEETLPQEEWEEKLLMF → GEARVRMGCIALWGGQVSE
     611-1641: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1641	1641	Maestro heat-like repeat-containing protein family member 1		PRO_0000329402
Regions
	Repeat	3 – 41	39	HEAT 1
	Repeat	159 – 198	40	HEAT 2
	Repeat	344 – 382	39	HEAT 3
	Repeat	385 – 423	39	HEAT 4
	Repeat	1048 – 1086	39	HEAT 5
	Repeat	1358 – 1396	39	HEAT 6
	Repeat	1605 – 1641	37	HEAT 7
Natural variations
	Alternative sequence	1 – 1038	1038	Missing in isoform 3.		VSP_032963
	Alternative sequence	1 – 68	68	Missing in isoform 6.		VSP_032965
	Alternative sequence	317 – 378	62	ICVPV…RHVIN → VGGGRQGAGPGSAHPSVGSC WTRGAESKLGWMAQPRGAED WAFPEGHSGDFLAMWRCSCP AQ in isoform 5.		VSP_032966
	Alternative sequence	379 – 1641	1263	Missing in isoform 5.		VSP_032967
	Alternative sequence	381 – 422	42	AAQME…AHHGY → GSTNTRITLMLPSAVTRLKH EDCPARAAPQPADLTAAPAS VA in isoform 4.		VSP_032968
	Alternative sequence	381 – 408	28	AAQME…SKVKR → GECLHASLAATPGHVQDGAG PGRLCPSK in isoform 6.		VSP_032969
	Alternative sequence	409 – 1641	1233	Missing in isoform 6.		VSP_032970
	Alternative sequence	423 – 1641	1219	Missing in isoform 4.		VSP_032971
	Alternative sequence	592 – 610	19	EHTEE…KLLMF → GEARVRMGCIALWGGQVSE in isoform 7.		VSP_032972
	Alternative sequence	611 – 1641	1031	Missing in isoform 7.		VSP_032973
	Alternative sequence	774 – 782	9	Missing in isoform 2.		VSP_032974
	Alternative sequence	1039 – 1040	2	GQ → MR in isoform 3.		VSP_032975
	Alternative sequence	1143 – 1156	14	SHTCM…LAVEP → RYPAQTPGLGVPLE in isoform 2.		VSP_032976
	Alternative sequence	1157 – 1641	485	Missing in isoform 2.		VSP_032977
	Alternative sequence	1593 – 1641	49	FLVLH…LVKLA → KHHPLPHPHAARQPRLMPPL HRVPGAALGAQAAAAGGPGP AHCGAPDPAEGPGPRGADEG C in isoform 3.		VSP_032978
	Natural variant	38	1	A → V. Ref.1 Ref.2 Ref.3 Ref.5 Ref.6 Corresponds to variant rs34819224 [ dbSNP | Ensembl ].		VAR_062166
Experimental info
	Sequence conflict	70	1	E → K in AK093563. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: FD194A308C021254	FASTA	1,641	181,249
	10 20 30 40 50 60 MTESSMKKLA STLLDAITDK DPLVQEQVCS ALCSLGEARP VETLRACEEY LRQHDKLAHP 70 80 90 100 110 120 YRAAVLRAME RVLSSRASEL DKDTASTIIL LASSEMTKTK DLVWDWQQAA SGVLVAVGRQ 130 140 150 160 170 180 FISKVMEELL RRLHPGTLPH CAVLHTLASL SVANAFGVVP FLPSVLSSLL PVLGVAKQDT 190 200 210 220 230 240 VRVAFCSALQ RFSEGALEYL ANLDRAPDPT VRKDAFATDI FSAYDVLFHQ WLQSREAKLR 250 260 270 280 290 300 LAVVEALGPM SHLLPSERLE EQLPKLLPGI LALYKKHAET FYLSKSLGQI LEAAVSVGSR 310 320 330 340 350 360 TLETQLDALL AALHSQICVP VESSSPLVMS NQKEVLRCFT VLACSSPDRL LAFLLPRLDT 370 380 390 400 410 420 SNERTRVGTL QVVRHVINSA AAQMEDKKPF ILSSMRLPLL DTNSKVKRAV VQVISAMAHH 430 440 450 460 470 480 GYLEQPGGEA MIEYIVQQCA LPPEQEPEKP GPGSKDPKAD SVRAISVRTL YLVSTTVDRM 490 500 510 520 530 540 SHVLWPYLLQ FLTPVRFTGA LTPLCRSLVH LAQKRQEAGA DAFLIQYDAH ASLPSPYAVT 550 560 570 580 590 600 GRLLVVSSSP YLGDGRGAAA LRLLSVLHPN IHPLLGQHWE TTVPLLLGYL DEHTEETLPQ 610 620 630 640 650 660 EEWEEKLLMF LRDTLAIISD NAWICQLSLE LCRQLPCYDE APQEKNFLYK CIGTTLGAAS 670 680 690 700 710 720 SKEVVRKHLQ ELLETARYQE EAEREGLACC FGICAISHLE DTLAQLEDFV RSEVFRKSIG 730 740 750 760 770 780 ILNIFKDRSE NEVEKVKSAL ILCYGHVAAR APRELVLAKV ESDILRNICQ HFSTKVLGIK 790 800 810 820 830 840 VETKDPALKL CLVQSVCMVS RAICSSTQAG SFHFTRKAEL VAQMMEFIRA EPPDSLRTPI 850 860 870 880 890 900 RKKAMLTCTY LVSVEPALDE QARADVIHGC LHSIMALLPE PKEEDGGCQK SLYLETLHAL 910 920 930 940 950 960 EDLLTSLLQR NMTPQGLQIM IEHLSPWIKS PRGHERARAL GLSALLLRYF LEHLRVSALV 970 980 990 1000 1010 1020 PFHNLGLLIG LFSPRCADLW PATRQEAVDC VYSLLYLQLG YEGFSRDYRD DVAERLLSLK 1030 1040 1050 1060 1070 1080 DGLVHPDPAI LFHTCHSVGQ IIAKRLPPDQ LISLLLTMFE ALGDPEKNCS RAATVMINCL 1090 1100 1110 1120 1130 1140 LQERGGVLQE KVPEIVSVLR SKLQEAQGEH VLPAAQHSVY LLATQHCAAV VSSLLGSPLP 1150 1160 1170 1180 1190 1200 LDSHTCMLWR ALAVEPRLAA QVLGLLLEKM SRDVPFKESR AFLLGRTPDR VATLLPLSAT 1210 1220 1230 1240 1250 1260 CALFEVMSTP AAGPAVLELY PQLFVVLLLR VSCTVGVQLP RNLQAQERRG ASPALATRNL 1270 1280 1290 1300 1310 1320 EPCSSAVDTL RSMLLRSGSE DVVQRMDLEG GWELLRTSAG HEEGATRLAR AMAEHAGPRL 1330 1340 1350 1360 1370 1380 PLVLKTLACT HSSAYENQRV TTTAFLAELL NSNVANDLML LDSLLESLAA RQKDTCASVR 1390 1400 1410 1420 1430 1440 RLVLRGLANL ASGCPDKVRT HGPQLLTAMI GGLDDGDNPH SPVALEAMLG LARLVHLVES 1450 1460 1470 1480 1490 1500 WDLRSGLLHV AIRIRPFFDS EKMEFRTASI RLFGHLNKVC HGDCEDVFLD QVVGGLAPLL 1510 1520 1530 1540 1550 1560 LHLQDPQATV ASACRFALRM CGPNLACEEL SAAFQKHLQE GRALHFGEFL NTTCKHLMHH 1570 1580 1590 1600 1610 1620 FPDLLGRLLT TCLFYFKSSW ENVRAAAPLF TGFLVLHSEP RQQPQVDLDQ LIAALQILLK 1630 1640 DPAPEVRTRA AEALGRLVKL A
	Isoform 2 [UniParc]. Checksum: 87F01077DC188B9E	FASTA	1,147	127,078
	10 20 30 40 50 60 MTESSMKKLA STLLDAITDK DPLVQEQVCS ALCSLGEARP VETLRACEEY LRQHDKLAHP 70 80 90 100 110 120 YRAAVLRAME RVLSSRASEL DKDTASTIIL LASSEMTKTK DLVWDWQQAA SGVLVAVGRQ 130 140 150 160 170 180 FISKVMEELL RRLHPGTLPH CAVLHTLASL SVANAFGVVP FLPSVLSSLL PVLGVAKQDT 190 200 210 220 230 240 VRVAFCSALQ RFSEGALEYL ANLDRAPDPT VRKDAFATDI FSAYDVLFHQ WLQSREAKLR 250 260 270 280 290 300 LAVVEALGPM SHLLPSERLE EQLPKLLPGI LALYKKHAET FYLSKSLGQI LEAAVSVGSR 310 320 330 340 350 360 TLETQLDALL AALHSQICVP VESSSPLVMS NQKEVLRCFT VLACSSPDRL LAFLLPRLDT 370 380 390 400 410 420 SNERTRVGTL QVVRHVINSA AAQMEDKKPF ILSSMRLPLL DTNSKVKRAV VQVISAMAHH 430 440 450 460 470 480 GYLEQPGGEA MIEYIVQQCA LPPEQEPEKP GPGSKDPKAD SVRAISVRTL YLVSTTVDRM 490 500 510 520 530 540 SHVLWPYLLQ FLTPVRFTGA LTPLCRSLVH LAQKRQEAGA DAFLIQYDAH ASLPSPYAVT 550 560 570 580 590 600 GRLLVVSSSP YLGDGRGAAA LRLLSVLHPN IHPLLGQHWE TTVPLLLGYL DEHTEETLPQ 610 620 630 640 650 660 EEWEEKLLMF LRDTLAIISD NAWICQLSLE LCRQLPCYDE APQEKNFLYK CIGTTLGAAS 670 680 690 700 710 720 SKEVVRKHLQ ELLETARYQE EAEREGLACC FGICAISHLE DTLAQLEDFV RSEVFRKSIG 730 740 750 760 770 780 ILNIFKDRSE NEVEKVKSAL ILCYGHVAAR APRELVLAKV ESDILRNICQ HFSTKDPALK 790 800 810 820 830 840 LCLVQSVCMV SRAICSSTQA GSFHFTRKAE LVAQMMEFIR AEPPDSLRTP IRKKAMLTCT 850 860 870 880 890 900 YLVSVEPALD EQARADVIHG CLHSIMALLP EPKEEDGGCQ KSLYLETLHA LEDLLTSLLQ 910 920 930 940 950 960 RNMTPQGLQI MIEHLSPWIK SPRGHERARA LGLSALLLRY FLEHLRVSAL VPFHNLGLLI 970 980 990 1000 1010 1020 GLFSPRCADL WPATRQEAVD CVYSLLYLQL GYEGFSRDYR DDVAERLLSL KDGLVHPDPA 1030 1040 1050 1060 1070 1080 ILFHTCHSVG QIIAKRLPPD QLISLLLTMF EALGDPEKNC SRAATVMINC LLQERGGVLQ 1090 1100 1110 1120 1130 1140 EKVPEIVSVL RSKLQEAQGE HVLPAAQHSV YLLATQHCAA VVSSLLGSPL PLDRYPAQTP GLGVPLE
	Isoform 3 [UniParc]. Checksum: F6330DAF247461C6	FASTA	615	66,506
	10 20 30 40 50 60 MRIIAKRLPP DQLISLLLTM FEALGDPEKN CSRAATVMIN CLLQERGGVL QEKVPEIVSV 70 80 90 100 110 120 LRSKLQEAQG EHVLPAAQHS VYLLATQHCA AVVSSLLGSP LPLDSHTCML WRALAVEPRL 130 140 150 160 170 180 AAQVLGLLLE KMSRDVPFKE SRAFLLGRTP DRVATLLPLS ATCALFEVMS TPAAGPAVLE 190 200 210 220 230 240 LYPQLFVVLL LRVSCTVGVQ LPRNLQAQER RGASPALATR NLEPCSSAVD TLRSMLLRSG 250 260 270 280 290 300 SEDVVQRMDL EGGWELLRTS AGHEEGATRL ARAMAEHAGP RLPLVLKTLA CTHSSAYENQ 310 320 330 340 350 360 RVTTTAFLAE LLNSNVANDL MLLDSLLESL AARQKDTCAS VRRLVLRGLA NLASGCPDKV 370 380 390 400 410 420 RTHGPQLLTA MIGGLDDGDN PHSPVALEAM LGLARLVHLV ESWDLRSGLL HVAIRIRPFF 430 440 450 460 470 480 DSEKMEFRTA SIRLFGHLNK VCHGDCEDVF LDQVVGGLAP LLLHLQDPQA TVASACRFAL 490 500 510 520 530 540 RMCGPNLACE ELSAAFQKHL QEGRALHFGE FLNTTCKHLM HHFPDLLGRL LTTCLFYFKS 550 560 570 580 590 600 SWENVRAAAP LFTGKHHPLP HPHAARQPRL MPPLHRVPGA ALGAQAAAAG GPGPAHCGAP 610 DPAEGPGPRG ADEGC
	Isoform 4 [UniParc]. Checksum: AB73844C342F523F	FASTA	422	46,043
	10 20 30 40 50 60 MTESSMKKLA STLLDAITDK DPLVQEQVCS ALCSLGEARP VETLRACEEY LRQHDKLAHP 70 80 90 100 110 120 YRAAVLRAME RVLSSRASEL DKDTASTIIL LASSEMTKTK DLVWDWQQAA SGVLVAVGRQ 130 140 150 160 170 180 FISKVMEELL RRLHPGTLPH CAVLHTLASL SVANAFGVVP FLPSVLSSLL PVLGVAKQDT 190 200 210 220 230 240 VRVAFCSALQ RFSEGALEYL ANLDRAPDPT VRKDAFATDI FSAYDVLFHQ WLQSREAKLR 250 260 270 280 290 300 LAVVEALGPM SHLLPSERLE EQLPKLLPGI LALYKKHAET FYLSKSLGQI LEAAVSVGSR 310 320 330 340 350 360 TLETQLDALL AALHSQICVP VESSSPLVMS NQKEVLRCFT VLACSSPDRL LAFLLPRLDT 370 380 390 400 410 420 SNERTRVGTL QVVRHVINSA GSTNTRITLM LPSAVTRLKH EDCPARAAPQ PADLTAAPAS VA
	Isoform 5 [UniParc]. Checksum: A7A6F681D2B5145C	FASTA	378	41,137
	10 20 30 40 50 60 MTESSMKKLA STLLDAITDK DPLVQEQVCS ALCSLGEARP VETLRACEEY LRQHDKLAHP 70 80 90 100 110 120 YRAAVLRAME RVLSSRASEL DKDTASTIIL LASSEMTKTK DLVWDWQQAA SGVLVAVGRQ 130 140 150 160 170 180 FISKVMEELL RRLHPGTLPH CAVLHTLASL SVANAFGVVP FLPSVLSSLL PVLGVAKQDT 190 200 210 220 230 240 VRVAFCSALQ RFSEGALEYL ANLDRAPDPT VRKDAFATDI FSAYDVLFHQ WLQSREAKLR 250 260 270 280 290 300 LAVVEALGPM SHLLPSERLE EQLPKLLPGI LALYKKHAET FYLSKSLGQI LEAAVSVGSR 310 320 330 340 350 360 TLETQLDALL AALHSQVGGG RQGAGPGSAH PSVGSCWTRG AESKLGWMAQ PRGAEDWAFP 370 EGHSGDFLAM WRCSCPAQ
	Isoform 6 [UniParc]. Checksum: 0065E6D4F1B7BD14	FASTA	340	36,918
	10 20 30 40 50 60 MERVLSSRAS ELDKDTASTI ILLASSEMTK TKDLVWDWQQ AASGVLVAVG RQFISKVMEE 70 80 90 100 110 120 LLRRLHPGTL PHCAVLHTLA SLSVANAFGV VPFLPSVLSS LLPVLGVAKQ DTVRVAFCSA 130 140 150 160 170 180 LQRFSEGALE YLANLDRAPD PTVRKDAFAT DIFSAYDVLF HQWLQSREAK LRLAVVEALG 190 200 210 220 230 240 PMSHLLPSER LEEQLPKLLP GILALYKKHA ETFYLSKSLG QILEAAVSVG SRTLETQLDA 250 260 270 280 290 300 LLAALHSQIC VPVESSSPLV MSNQKEVLRC FTVLACSSPD RLLAFLLPRL DTSNERTRVG 310 320 330 340 TLQVVRHVIN SAGECLHASL AATPGHVQDG AGPGRLCPSK
	Isoform 7 [UniParc]. Checksum: 7D2B88D7EAEF6BA1	FASTA	610	66,868
	10 20 30 40 50 60 MTESSMKKLA STLLDAITDK DPLVQEQVCS ALCSLGEARP VETLRACEEY LRQHDKLAHP 70 80 90 100 110 120 YRAAVLRAME RVLSSRASEL DKDTASTIIL LASSEMTKTK DLVWDWQQAA SGVLVAVGRQ 130 140 150 160 170 180 FISKVMEELL RRLHPGTLPH CAVLHTLASL SVANAFGVVP FLPSVLSSLL PVLGVAKQDT 190 200 210 220 230 240 VRVAFCSALQ RFSEGALEYL ANLDRAPDPT VRKDAFATDI FSAYDVLFHQ WLQSREAKLR 250 260 270 280 290 300 LAVVEALGPM SHLLPSERLE EQLPKLLPGI LALYKKHAET FYLSKSLGQI LEAAVSVGSR 310 320 330 340 350 360 TLETQLDALL AALHSQICVP VESSSPLVMS NQKEVLRCFT VLACSSPDRL LAFLLPRLDT 370 380 390 400 410 420 SNERTRVGTL QVVRHVINSA AAQMEDKKPF ILSSMRLPLL DTNSKVKRAV VQVISAMAHH 430 440 450 460 470 480 GYLEQPGGEA MIEYIVQQCA LPPEQEPEKP GPGSKDPKAD SVRAISVRTL YLVSTTVDRM 490 500 510 520 530 540 SHVLWPYLLQ FLTPVRFTGA LTPLCRSLVH LAQKRQEAGA DAFLIQYDAH ASLPSPYAVT 550 560 570 580 590 600 GRLLVVSSSP YLGDGRGAAA LRLLSVLHPN IHPLLGQHWE TTVPLLLGYL DGEARVRMGC 610 IALWGGQVSE

References

[1]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-38. Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 384-1641 (ISOFORM 7), VARIANT VAL-38. Tissue: Spleen and Thymus.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT VAL-38. Tissue: Testis.
[4]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-38.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 6), VARIANT VAL-38. Tissue: Blood and Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB058736 mRNA. Translation: BAB47462.1. Different initiation. AK092861 mRNA. No translation available. AK093563 mRNA. No translation available. AL834309 mRNA. Translation: CAD38979.1. Different initiation. AL834145 mRNA. Translation: CAD38858.1. AC104592 Genomic DNA. No translation available. AC145291 Genomic DNA. No translation available. CH471162 Genomic DNA. Translation: EAW82134.1. CH471162 Genomic DNA. Translation: EAW82137.1. CH471162 Genomic DNA. Translation: EAW82143.1. BC040742 mRNA. Translation: AAH40742.1. BC092486 mRNA. Translation: AAH92486.1. Different initiation. BC057824 mRNA. Translation: AAH57824.1. Different initiation. BC067855 mRNA. Translation: AAH67855.1. Different initiation.
IPI	IPI00167967. IPI00386045. IPI00787261. IPI00889514. IPI00889659. IPI00889691. IPI00889776.
RefSeq	NP_001092750.1. NM_001099280.1. NP_001092751.1. NM_001099281.1. NP_115826.2. NM_032450.2.
UniGene	Hs.443139.
3D structure databases
ProteinModelPortal	Q8NDA8.
SMR	Q8NDA8. Positions 1325-1395.
ModBase	Search...
PTM databases
PhosphoSite	Q8NDA8.
Polymorphism databases
DMDM	296439329.
Proteomic databases
PaxDb	Q8NDA8.
PRIDE	Q8NDA8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326134; ENSP00000321737; ENSG00000179832. ENST00000398656; ENSP00000381649; ENSG00000179832. ENST00000423230; ENSP00000388174; ENSG00000179832. ENST00000528919; ENSP00000435565; ENSG00000179832. ENST00000544576; ENSP00000437866; ENSG00000179832. ENST00000562181; ENSP00000454801; ENSG00000260383. ENST00000568089; ENSP00000455272; ENSG00000260383.
GeneID	727957.
KEGG	hsa:727957.
UCSC	uc003zbg.2. human. uc003zbh.4. human. uc003zbk.4. human. uc003zbl.4. human. uc011lla.1. human.
Organism-specific databases
CTD	727957.
GeneCards	GC08P145202.
H-InvDB	HIX0188658.
HGNC	HGNC:26958. MROH1.
HPA	HPA044465.
neXtProt	NX_Q8NDA8.
PharmGKB	PA164720350.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG291078.
HOVERGEN	HBG107983.
InParanoid	Q8NDA8.
OMA	PRCIDSN.
OrthoDB	EOG4PC9S1.
Gene expression databases
ArrayExpress	Q8NDA8.
Bgee	Q8NDA8.
CleanEx	HS_HEATR7A.
Genevestigator	Q8NDA8.
Family and domain databases
Gene3D	1.25.10.10. 6 hits.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000357. HEAT. IPR021133. HEAT_type_2. [Graphical view]
Pfam	PF02985. HEAT. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 2 hits.
PROSITE	PS50077. HEAT_REPEAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HEATR7A. human.
GenomeRNAi	727957.
NextBio	125683.

Entry information

Entry name

MROH1_HUMAN

Accession

Primary (citable) accession number: Q8NDA8
Secondary accession number(s): C9JWM5 , D3DWL5, Q0P612, Q569G6, Q6NVW4, Q8N230, Q8NAD1, Q8ND95, Q96JJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 80 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.