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Protein

Maestro heat-like repeat-containing protein family member 1

Gene

MROH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Maestro heat-like repeat-containing protein family member 1
Alternative name(s):
HEAT repeat-containing protein 7A
Gene namesi
Name:MROH1
Synonyms:HEATR7A, KIAA1833
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:26958. MROH1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi727957.
OpenTargetsiENSG00000179832.
PharmGKBiPA164720350.

Polymorphism and mutation databases

BioMutaiMROH1.
DMDMi296439329.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003294021 – 1641Maestro heat-like repeat-containing protein family member 1Add BLAST1641

Proteomic databases

EPDiQ8NDA8.
MaxQBiQ8NDA8.
PaxDbiQ8NDA8.
PeptideAtlasiQ8NDA8.
PRIDEiQ8NDA8.

PTM databases

iPTMnetiQ8NDA8.
PhosphoSitePlusiQ8NDA8.

Expressioni

Gene expression databases

BgeeiENSG00000179832.
CleanExiHS_HEATR7A.
ExpressionAtlasiQ8NDA8. baseline and differential.
GenevisibleiQ8NDA8. HS.

Organism-specific databases

HPAiHPA044465.

Interactioni

Protein-protein interaction databases

BioGridi608397. 4 interactors.
IntActiQ8NDA8. 1 interactor.
STRINGi9606.ENSP00000321737.

Structurei

3D structure databases

ProteinModelPortaliQ8NDA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati3 – 41HEAT 1Add BLAST39
Repeati159 – 198HEAT 2Add BLAST40
Repeati344 – 382HEAT 3Add BLAST39
Repeati385 – 423HEAT 4Add BLAST39
Repeati1048 – 1086HEAT 5Add BLAST39
Repeati1358 – 1396HEAT 6Add BLAST39
Repeati1605 – 1641HEAT 7Add BLAST37

Sequence similaritiesi

Contains 7 HEAT repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2032. Eukaryota.
ENOG410XQE8. LUCA.
GeneTreeiENSGT00860000133736.
HOVERGENiHBG107983.
InParanoidiQ8NDA8.
OMAiWHLVCND.
OrthoDBiEOG091G00DQ.
PhylomeDBiQ8NDA8.
TreeFamiTF315201.

Family and domain databases

Gene3Di1.25.10.10. 6 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR021133. HEAT_type_2.
[Graphical view]
PfamiPF02985. HEAT. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 8 hits.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NDA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTESSMKKLA STLLDAITDK DPLVQEQVCS ALCSLGEARP VETLRACEEY
60 70 80 90 100
LRQHDKLAHP YRAAVLRAME RVLSSRASEL DKDTASTIIL LASSEMTKTK
110 120 130 140 150
DLVWDWQQAA SGVLVAVGRQ FISKVMEELL RRLHPGTLPH CAVLHTLASL
160 170 180 190 200
SVANAFGVVP FLPSVLSSLL PVLGVAKQDT VRVAFCSALQ RFSEGALEYL
210 220 230 240 250
ANLDRAPDPT VRKDAFATDI FSAYDVLFHQ WLQSREAKLR LAVVEALGPM
260 270 280 290 300
SHLLPSERLE EQLPKLLPGI LALYKKHAET FYLSKSLGQI LEAAVSVGSR
310 320 330 340 350
TLETQLDALL AALHSQICVP VESSSPLVMS NQKEVLRCFT VLACSSPDRL
360 370 380 390 400
LAFLLPRLDT SNERTRVGTL QVVRHVINSA AAQMEDKKPF ILSSMRLPLL
410 420 430 440 450
DTNSKVKRAV VQVISAMAHH GYLEQPGGEA MIEYIVQQCA LPPEQEPEKP
460 470 480 490 500
GPGSKDPKAD SVRAISVRTL YLVSTTVDRM SHVLWPYLLQ FLTPVRFTGA
510 520 530 540 550
LTPLCRSLVH LAQKRQEAGA DAFLIQYDAH ASLPSPYAVT GRLLVVSSSP
560 570 580 590 600
YLGDGRGAAA LRLLSVLHPN IHPLLGQHWE TTVPLLLGYL DEHTEETLPQ
610 620 630 640 650
EEWEEKLLMF LRDTLAIISD NAWICQLSLE LCRQLPCYDE APQEKNFLYK
660 670 680 690 700
CIGTTLGAAS SKEVVRKHLQ ELLETARYQE EAEREGLACC FGICAISHLE
710 720 730 740 750
DTLAQLEDFV RSEVFRKSIG ILNIFKDRSE NEVEKVKSAL ILCYGHVAAR
760 770 780 790 800
APRELVLAKV ESDILRNICQ HFSTKVLGIK VETKDPALKL CLVQSVCMVS
810 820 830 840 850
RAICSSTQAG SFHFTRKAEL VAQMMEFIRA EPPDSLRTPI RKKAMLTCTY
860 870 880 890 900
LVSVEPALDE QARADVIHGC LHSIMALLPE PKEEDGGCQK SLYLETLHAL
910 920 930 940 950
EDLLTSLLQR NMTPQGLQIM IEHLSPWIKS PRGHERARAL GLSALLLRYF
960 970 980 990 1000
LEHLRVSALV PFHNLGLLIG LFSPRCADLW PATRQEAVDC VYSLLYLQLG
1010 1020 1030 1040 1050
YEGFSRDYRD DVAERLLSLK DGLVHPDPAI LFHTCHSVGQ IIAKRLPPDQ
1060 1070 1080 1090 1100
LISLLLTMFE ALGDPEKNCS RAATVMINCL LQERGGVLQE KVPEIVSVLR
1110 1120 1130 1140 1150
SKLQEAQGEH VLPAAQHSVY LLATQHCAAV VSSLLGSPLP LDSHTCMLWR
1160 1170 1180 1190 1200
ALAVEPRLAA QVLGLLLEKM SRDVPFKESR AFLLGRTPDR VATLLPLSAT
1210 1220 1230 1240 1250
CALFEVMSTP AAGPAVLELY PQLFVVLLLR VSCTVGVQLP RNLQAQERRG
1260 1270 1280 1290 1300
ASPALATRNL EPCSSAVDTL RSMLLRSGSE DVVQRMDLEG GWELLRTSAG
1310 1320 1330 1340 1350
HEEGATRLAR AMAEHAGPRL PLVLKTLACT HSSAYENQRV TTTAFLAELL
1360 1370 1380 1390 1400
NSNVANDLML LDSLLESLAA RQKDTCASVR RLVLRGLANL ASGCPDKVRT
1410 1420 1430 1440 1450
HGPQLLTAMI GGLDDGDNPH SPVALEAMLG LARLVHLVES WDLRSGLLHV
1460 1470 1480 1490 1500
AIRIRPFFDS EKMEFRTASI RLFGHLNKVC HGDCEDVFLD QVVGGLAPLL
1510 1520 1530 1540 1550
LHLQDPQATV ASACRFALRM CGPNLACEEL SAAFQKHLQE GRALHFGEFL
1560 1570 1580 1590 1600
NTTCKHLMHH FPDLLGRLLT TCLFYFKSSW ENVRAAAPLF TGFLVLHSEP
1610 1620 1630 1640
RQQPQVDLDQ LIAALQILLK DPAPEVRTRA AEALGRLVKL A
Length:1,641
Mass (Da):181,249
Last modified:May 18, 2010 - v3
Checksum:iFD194A308C021254
GO
Isoform 2 (identifier: Q8NDA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     774-782: Missing.
     1143-1156: SHTCMLWRALAVEP → RYPAQTPGLGVPLE
     1157-1641: Missing.

Show »
Length:1,147
Mass (Da):127,078
Checksum:i87F01077DC188B9E
GO
Isoform 3 (identifier: Q8NDA8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1038: Missing.
     1039-1040: GQ → MR
     1593-1641: FLVLHSEPRQ...EALGRLVKLA → KHHPLPHPHA...PGPRGADEGC

Show »
Length:615
Mass (Da):66,506
Checksum:iF6330DAF247461C6
GO
Isoform 4 (identifier: Q8NDA8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     381-422: AAQMEDKKPF...VISAMAHHGY → GSTNTRITLM...DLTAAPASVA
     423-1641: Missing.

Show »
Length:422
Mass (Da):46,043
Checksum:iAB73844C342F523F
GO
Isoform 5 (identifier: Q8NDA8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-378: ICVPVESSSP...TLQVVRHVIN → VGGGRQGAGP...AMWRCSCPAQ
     379-1641: Missing.

Show »
Length:378
Mass (Da):41,137
Checksum:iA7A6F681D2B5145C
GO
Isoform 6 (identifier: Q8NDA8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
     381-408: AAQMEDKKPFILSSMRLPLLDTNSKVKR → GECLHASLAATPGHVQDGAGPGRLCPSK
     409-1641: Missing.

Show »
Length:340
Mass (Da):36,918
Checksum:i0065E6D4F1B7BD14
GO
Isoform 7 (identifier: Q8NDA8-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     592-610: EHTEETLPQEEWEEKLLMF → GEARVRMGCIALWGGQVSE
     611-1641: Missing.

Show »
Length:610
Mass (Da):66,868
Checksum:i7D2B88D7EAEF6BA1
GO

Sequence cautioni

The sequence AAH57824 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH67855 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH92486 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB47462 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAD38979 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70E → K in AK093563 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06216638A → V.5 PublicationsCorresponds to variant rs34819224dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0329631 – 1038Missing in isoform 3. 1 PublicationAdd BLAST1038
Alternative sequenceiVSP_0329651 – 68Missing in isoform 6. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_032966317 – 378ICVPV…RHVIN → VGGGRQGAGPGSAHPSVGSC WTRGAESKLGWMAQPRGAED WAFPEGHSGDFLAMWRCSCP AQ in isoform 5. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_032967379 – 1641Missing in isoform 5. 1 PublicationAdd BLAST1263
Alternative sequenceiVSP_032968381 – 422AAQME…AHHGY → GSTNTRITLMLPSAVTRLKH EDCPARAAPQPADLTAAPAS VA in isoform 4. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_032969381 – 408AAQME…SKVKR → GECLHASLAATPGHVQDGAG PGRLCPSK in isoform 6. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_032970409 – 1641Missing in isoform 6. 1 PublicationAdd BLAST1233
Alternative sequenceiVSP_032971423 – 1641Missing in isoform 4. 1 PublicationAdd BLAST1219
Alternative sequenceiVSP_032972592 – 610EHTEE…KLLMF → GEARVRMGCIALWGGQVSE in isoform 7. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_032973611 – 1641Missing in isoform 7. 1 PublicationAdd BLAST1031
Alternative sequenceiVSP_032974774 – 782Missing in isoform 2. 1 Publication9
Alternative sequenceiVSP_0329751039 – 1040GQ → MR in isoform 3. 1 Publication2
Alternative sequenceiVSP_0329761143 – 1156SHTCM…LAVEP → RYPAQTPGLGVPLE in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0329771157 – 1641Missing in isoform 2. 1 PublicationAdd BLAST485
Alternative sequenceiVSP_0329781593 – 1641FLVLH…LVKLA → KHHPLPHPHAARQPRLMPPL HRVPGAALGAQAAAAGGPGP AHCGAPDPAEGPGPRGADEG C in isoform 3. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058736 mRNA. Translation: BAB47462.1. Different initiation.
AK092861 mRNA. No translation available.
AK093563 mRNA. No translation available.
AL834309 mRNA. Translation: CAD38979.1. Different initiation.
AL834145 mRNA. Translation: CAD38858.1.
AC104592 Genomic DNA. No translation available.
AC145291 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82134.1.
CH471162 Genomic DNA. Translation: EAW82137.1.
CH471162 Genomic DNA. Translation: EAW82143.1.
BC040742 mRNA. Translation: AAH40742.1.
BC092486 mRNA. Translation: AAH92486.1. Different initiation.
BC057824 mRNA. Translation: AAH57824.1. Different initiation.
BC067855 mRNA. Translation: AAH67855.1. Different initiation.
CCDSiCCDS47938.1. [Q8NDA8-1]
CCDS47939.1. [Q8NDA8-4]
RefSeqiNP_001092750.1. NM_001099280.2.
NP_001092751.1. NM_001099281.2.
NP_001275743.1. NM_001288814.1.
NP_115826.2. NM_032450.2.
XP_011515587.1. XM_011517285.1. [Q8NDA8-2]
UniGeneiHs.443139.

Genome annotation databases

EnsembliENST00000326134; ENSP00000321737; ENSG00000179832. [Q8NDA8-1]
ENST00000423230; ENSP00000388174; ENSG00000179832. [Q8NDA8-4]
ENST00000528919; ENSP00000435565; ENSG00000179832. [Q8NDA8-1]
ENST00000544576; ENSP00000437866; ENSG00000179832. [Q8NDA8-3]
GeneIDi727957.
KEGGihsa:727957.
UCSCiuc003zbi.5. human. [Q8NDA8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058736 mRNA. Translation: BAB47462.1. Different initiation.
AK092861 mRNA. No translation available.
AK093563 mRNA. No translation available.
AL834309 mRNA. Translation: CAD38979.1. Different initiation.
AL834145 mRNA. Translation: CAD38858.1.
AC104592 Genomic DNA. No translation available.
AC145291 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82134.1.
CH471162 Genomic DNA. Translation: EAW82137.1.
CH471162 Genomic DNA. Translation: EAW82143.1.
BC040742 mRNA. Translation: AAH40742.1.
BC092486 mRNA. Translation: AAH92486.1. Different initiation.
BC057824 mRNA. Translation: AAH57824.1. Different initiation.
BC067855 mRNA. Translation: AAH67855.1. Different initiation.
CCDSiCCDS47938.1. [Q8NDA8-1]
CCDS47939.1. [Q8NDA8-4]
RefSeqiNP_001092750.1. NM_001099280.2.
NP_001092751.1. NM_001099281.2.
NP_001275743.1. NM_001288814.1.
NP_115826.2. NM_032450.2.
XP_011515587.1. XM_011517285.1. [Q8NDA8-2]
UniGeneiHs.443139.

3D structure databases

ProteinModelPortaliQ8NDA8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi608397. 4 interactors.
IntActiQ8NDA8. 1 interactor.
STRINGi9606.ENSP00000321737.

PTM databases

iPTMnetiQ8NDA8.
PhosphoSitePlusiQ8NDA8.

Polymorphism and mutation databases

BioMutaiMROH1.
DMDMi296439329.

Proteomic databases

EPDiQ8NDA8.
MaxQBiQ8NDA8.
PaxDbiQ8NDA8.
PeptideAtlasiQ8NDA8.
PRIDEiQ8NDA8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326134; ENSP00000321737; ENSG00000179832. [Q8NDA8-1]
ENST00000423230; ENSP00000388174; ENSG00000179832. [Q8NDA8-4]
ENST00000528919; ENSP00000435565; ENSG00000179832. [Q8NDA8-1]
ENST00000544576; ENSP00000437866; ENSG00000179832. [Q8NDA8-3]
GeneIDi727957.
KEGGihsa:727957.
UCSCiuc003zbi.5. human. [Q8NDA8-1]

Organism-specific databases

CTDi727957.
DisGeNETi727957.
GeneCardsiMROH1.
H-InvDBHIX0188658.
HGNCiHGNC:26958. MROH1.
HPAiHPA044465.
neXtProtiNX_Q8NDA8.
OpenTargetsiENSG00000179832.
PharmGKBiPA164720350.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2032. Eukaryota.
ENOG410XQE8. LUCA.
GeneTreeiENSGT00860000133736.
HOVERGENiHBG107983.
InParanoidiQ8NDA8.
OMAiWHLVCND.
OrthoDBiEOG091G00DQ.
PhylomeDBiQ8NDA8.
TreeFamiTF315201.

Miscellaneous databases

GenomeRNAii727957.
PROiQ8NDA8.

Gene expression databases

BgeeiENSG00000179832.
CleanExiHS_HEATR7A.
ExpressionAtlasiQ8NDA8. baseline and differential.
GenevisibleiQ8NDA8. HS.

Family and domain databases

Gene3Di1.25.10.10. 6 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR021133. HEAT_type_2.
[Graphical view]
PfamiPF02985. HEAT. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 8 hits.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMROH1_HUMAN
AccessioniPrimary (citable) accession number: Q8NDA8
Secondary accession number(s): C9JWM5
, D3DWL5, Q0P612, Q569G6, Q6NVW4, Q8N230, Q8NAD1, Q8ND95, Q96JJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.