ID HMCN2_HUMAN Reviewed; 5079 AA. AC Q8NDA2; A0A096LP30; A0A804HLC3; Q8N225; Q8TCI8; DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot. DT 24-JAN-2024, sequence version 4. DT 27-MAR-2024, entry version 148. DE RecName: Full=Hemicentin-2 {ECO:0000305}; DE Flags: Precursor; GN Name=HMCN2 {ECO:0000312|HGNC:HGNC:21293}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., RA Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3097-5079 (ISOFORM 3). RC TISSUE=Testis; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3807-5079 (ISOFORM 2). RC TISSUE=Small intestine, and Thymus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular CC matrix {ECO:0000250|UniProtKB:A2AJ76}. Cleavage furrow CC {ECO:0000250|UniProtKB:A2AJ76}. Note=The antibody used to determine CC subcellular location does not distinguish between HMCN1 and HMCN2. CC {ECO:0000250|UniProtKB:A2AJ76}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=2; CC IsoId=Q8NDA2-5; Sequence=Displayed; CC Name=1; CC IsoId=Q8NDA2-1; Sequence=VSP_062146; CC Name=3; CC IsoId=Q8NDA2-4; Sequence=VSP_062145, VSP_062146, VSP_062147, CC VSP_062148; CC -!- MISCELLANEOUS: [Isoform 2]: Gene prediction based on partial EST and CC mRNA data. {ECO:0000305}. CC -!- MISCELLANEOUS: [Isoform 1]: Gene prediction based on partial EST and CC mRNA data. {ECO:0000305}. CC -!- MISCELLANEOUS: [Isoform 3]: Dubious isoform produced through intron CC retention. {ECO:0000305}. CC -!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator. CC {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAB85069.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=BAC04201.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; CC Sequence=CAD38854.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=EAW87931.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; ABBA01012042; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ABBA01043973; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL354898; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL360004; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AUXG01000072; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; FP565345; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458942; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471090; EAW87931.1; ALT_SEQ; Genomic_DNA. DR EMBL; AL834139; CAD38854.1; ALT_INIT; mRNA. DR EMBL; AK074396; BAB85069.1; ALT_INIT; mRNA. DR EMBL; AK093583; BAC04201.1; ALT_SEQ; mRNA. DR RefSeq; NP_001278744.1; NM_001291815.1. [Q8NDA2-5] DR STRING; 9606.ENSP00000485357; -. DR GlyCosmos; Q8NDA2; 40 sites, No reported glycans. DR GlyGen; Q8NDA2; 42 sites, 1 O-linked glycan (2 sites). DR iPTMnet; Q8NDA2; -. DR PhosphoSitePlus; Q8NDA2; -. DR SwissPalm; Q8NDA2; -. DR BioMuta; HMCN2; -. DR DMDM; 298351848; -. DR EPD; Q8NDA2; -. DR jPOST; Q8NDA2; -. DR MassIVE; Q8NDA2; -. DR PaxDb; 9606-ENSP00000485357; -. DR PeptideAtlas; Q8NDA2; -. DR ProteomicsDB; 72996; -. [Q8NDA2-1] DR Antibodypedia; 65468; 29 antibodies from 7 providers. DR Ensembl; ENST00000624552.4; ENSP00000485357.2; ENSG00000148357.18. [Q8NDA2-1] DR Ensembl; ENST00000683500.2; ENSP00000508292.2; ENSG00000148357.18. [Q8NDA2-5] DR GeneID; 256158; -. DR KEGG; hsa:256158; -. DR MANE-Select; ENST00000683500.2; ENSP00000508292.2; NM_001291815.2; NP_001278744.1. DR UCSC; uc064wnb.1; human. DR AGR; HGNC:21293; -. DR CTD; 256158; -. DR GeneCards; HMCN2; -. DR HGNC; HGNC:21293; HMCN2. DR HPA; ENSG00000148357; Tissue enhanced (endometrium, intestine). DR neXtProt; NX_Q8NDA2; -. DR OpenTargets; ENSG00000148357; -. DR PharmGKB; PA142671680; -. DR VEuPathDB; HostDB:ENSG00000148357; -. DR eggNOG; KOG1217; Eukaryota. DR eggNOG; KOG4475; Eukaryota. DR GeneTree; ENSGT00940000162328; -. DR InParanoid; Q8NDA2; -. DR PathwayCommons; Q8NDA2; -. DR ChiTaRS; HMCN2; human. DR Pharos; Q8NDA2; Tdark. DR PRO; PR:Q8NDA2; -. DR Proteomes; UP000005640; Chromosome 9. DR RNAct; Q8NDA2; Protein. DR Bgee; ENSG00000148357; Expressed in muscle layer of sigmoid colon and 131 other cell types or tissues. DR ExpressionAtlas; Q8NDA2; baseline and differential. DR GO; GO:0030424; C:axon; IBA:GO_Central. DR GO; GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell. DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW. DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0008046; F:axon guidance receptor activity; IBA:GO_Central. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central. DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW. DR GO; GO:0050808; P:synapse organization; IBA:GO_Central. DR CDD; cd00054; EGF_CA; 5. DR CDD; cd00096; Ig; 8. DR CDD; cd00198; vWFA; 1. DR Gene3D; 2.40.155.10; Green fluorescent protein; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 43. DR Gene3D; 2.10.25.10; Laminin; 6. DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1. DR InterPro; IPR026823; cEGF. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR006605; G2_nidogen/fibulin_G2F. DR InterPro; IPR009017; GFP. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR013106; Ig_V-set. DR InterPro; IPR036465; vWFA_dom_sf. DR PANTHER; PTHR10075; BASIGIN RELATED; 1. DR PANTHER; PTHR10075:SF109; FASCICLIN-2; 1. DR Pfam; PF12662; cEGF; 1. DR Pfam; PF07645; EGF_CA; 4. DR Pfam; PF07474; G2F; 1. DR Pfam; PF07679; I-set; 31. DR Pfam; PF13927; Ig_3; 11. DR SMART; SM00181; EGF; 6. DR SMART; SM00179; EGF_CA; 6. DR SMART; SM00682; G2F; 1. DR SMART; SM00409; IG; 43. DR SMART; SM00408; IGc2; 43. DR SMART; SM00406; IGv; 14. DR SUPFAM; SSF57196; EGF/Laminin; 1. DR SUPFAM; SSF54511; GFP-like; 1. DR SUPFAM; SSF57184; Growth factor receptor domain; 2. DR SUPFAM; SSF48726; Immunoglobulin; 43. DR SUPFAM; SSF53300; vWA-like; 1. DR PROSITE; PS00010; ASX_HYDROXYL; 3. DR PROSITE; PS01186; EGF_2; 3. DR PROSITE; PS50026; EGF_3; 5. DR PROSITE; PS01187; EGF_CA; 5. DR PROSITE; PS50835; IG_LIKE; 42. DR PROSITE; PS50993; NIDOGEN_G2; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Calcium; Disulfide bond; EGF-like domain; KW Extracellular matrix; Glycoprotein; Immunoglobulin domain; Methylation; KW Reference proteome; Repeat; Secreted; Sensory transduction; Signal. FT SIGNAL 1..23 FT /evidence="ECO:0000255" FT CHAIN 24..5079 FT /note="Hemicentin-2" FT /id="PRO_0000395108" FT DOMAIN 39..206 FT /note="VWFA" FT DOMAIN 518..603 FT /note="Ig-like C2-type 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 608..691 FT /note="Ig-like C2-type 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 698..781 FT /note="Ig-like C2-type 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 786..880 FT /note="Ig-like C2-type 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 885..971 FT /note="Ig-like C2-type 5" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 976..1062 FT /note="Ig-like C2-type 6" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 1067..1160 FT /note="Ig-like C2-type 7" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 1165..1245 FT /note="Ig-like C2-type 8" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 1266..1339 FT /note="Ig-like C2-type 9" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 1344..1430 FT /note="Ig-like C2-type 10" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 1437..1526 FT /note="Ig-like C2-type 11" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 1531..1619 FT /note="Ig-like C2-type 12" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 1624..1715 FT /note="Ig-like C2-type 13" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 1718..1806 FT /note="Ig-like C2-type 14" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 1811..1888 FT /note="Ig-like C2-type 15" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 1895..1983 FT /note="Ig-like C2-type 16" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 1986..2075 FT /note="Ig-like C2-type 17" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 2080..2166 FT /note="Ig-like C2-type 18" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 2171..2262 FT /note="Ig-like C2-type 19" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 2265..2354 FT /note="Ig-like C2-type 20" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 2359..2448 FT /note="Ig-like C2-type 21" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 2453..2541 FT /note="Ig-like C2-type 22" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 2546..2637 FT /note="Ig-like C2-type 23" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 2642..2733 FT /note="Ig-like C2-type 24" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 2740..2834 FT /note="Ig-like C2-type 25" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 2850..2939 FT /note="Ig-like C2-type 26" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 2946..3033 FT /note="Ig-like C2-type 27" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 3038..3128 FT /note="Ig-like C2-type 28" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 3132..3220 FT /note="Ig-like C2-type 29" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 3225..3315 FT /note="Ig-like C2-type 30" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 3320..3407 FT /note="Ig-like C2-type 31" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 3413..3498 FT /note="Ig-like C2-type 32" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 3503..3589 FT /note="Ig-like C2-type 33" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 3594..3682 FT /note="Ig-like C2-type 34" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 3687..3773 FT /note="Ig-like C2-type 35" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 3797..3868 FT /note="Ig-like C2-type 36" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 3871..3957 FT /note="Ig-like C2-type 37" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 3962..4047 FT /note="Ig-like C2-type 38" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 4051..4138 FT /note="Ig-like C2-type 39" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 4143..4224 FT /note="Ig-like C2-type 40" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 4232..4315 FT /note="Ig-like C2-type 41" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 4323..4408 FT /note="Ig-like C2-type 42" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DOMAIN 4412..4634 FT /note="Nidogen G2 beta-barrel" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00348" FT DOMAIN 4648..4688 FT /note="EGF-like 1; calcium-binding" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT DOMAIN 4689..4732 FT /note="EGF-like 2; calcium-binding" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT DOMAIN 4733..4771 FT /note="EGF-like 3; calcium-binding" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT DOMAIN 4776..4816 FT /note="EGF-like 4; calcium-binding" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT DOMAIN 4883..4922 FT /note="EGF-like 5; calcium-binding" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT REGION 1271..1298 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 912 FT /note="Omega-N-methylarginine" FT /evidence="ECO:0000250|UniProtKB:A2AJ76" FT MOD_RES 917 FT /note="Omega-N-methylarginine" FT /evidence="ECO:0000250|UniProtKB:A2AJ76" FT CARBOHYD 329 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 346 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 379 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 478 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 525 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 547 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 674 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 1024 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 1072 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 1268 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 1354 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 1537 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 1563 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 1671 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 1820 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 1909 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 2009 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 2088 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 2094 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 2252 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 2290 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 2370 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 2444 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 2477 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 2516 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 2581 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 2663 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 2867 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 2961 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 3405 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 3535 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 3550 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 3697 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 3701 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 4082 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 4284 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 4435 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 4581 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 4824 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 5014 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT DISULFID 538..587 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 629..677 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 719..765 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 807..862 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 906..955 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 997..1046 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 1095..1144 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 1186..1229 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 1273..1323 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 1367..1416 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 1460..1510 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 1554..1603 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 1648..1697 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 1741..1790 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 1833..1874 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 1916..1965 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 2008..2059 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 2101..2150 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 2193..2244 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 2289..2338 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 2383..2432 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 2476..2525 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 2572..2621 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 2670..2719 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 2781..2830 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 2876..2925 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 2968..3017 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 3063..3112 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 3155..3204 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 3248..3299 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 3344..3393 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 3437..3482 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 3526..3573 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 3617..3666 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 3708..3757 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 3799..3850 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 3892..3941 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 3983..4031 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 4073..4122 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 4164..4211 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 4254..4302 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 4344..4392 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" FT DISULFID 4652..4663 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT DISULFID 4659..4672 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT DISULFID 4674..4687 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT DISULFID 4693..4706 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT DISULFID 4700..4715 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT DISULFID 4719..4731 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT DISULFID 4737..4750 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT DISULFID 4744..4759 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT DISULFID 4780..4791 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT DISULFID 4787..4800 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT DISULFID 4802..4815 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT DISULFID 4887..4897 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT DISULFID 4893..4906 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT DISULFID 4908..4921 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" FT VAR_SEQ 3410..3449 FT /note="VQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSW -> CPLSWSRW FT SSRMTWWWFVAPWWNSRARPGAFPCLSCRG (in isoform 3)" FT /id="VSP_062145" FT VAR_SEQ 3776..3794 FT /note="Missing (in isoform 1 and isoform 3)" FT /id="VSP_062146" FT VAR_SEQ 4412..4457 FT /note="EPQGSWGSMTGVINGRKFGVATLNTSVMQEAHSGVSSIHSSIRHVP -> MG FT HPCLDLRGQRQDLLPMGIVWCLWETCPLPCQLPTSSLCFITSPE (in isoform FT 3)" FT /id="VSP_062147" FT VAR_SEQ 4458..5079 FT /note="Missing (in isoform 3)" FT /id="VSP_062148" FT CONFLICT 3290 FT /note="R -> W (in Ref. 3; CAD38854)" FT /evidence="ECO:0000305" FT CONFLICT 4290 FT /note="R -> H (in Ref. 3; CAD38854)" FT /evidence="ECO:0000305" SQ SEQUENCE 5079 AA; 544006 MW; 9C28AD2582FDAE48 CRC64; MMPGAPLLRL LTAVSAAVAV AVAGAPGTVM PPTTGDATLA FVFDVTGSMW DELMQVIDGA SRILERSLSR RSQAIANYAL VPFHDPDIGP VTLTADPTVF QRELRELYVQ GGGDCPEMSV GAIKAAVEVA NPGSFIYVFS DARAKDYHKK EELLRLLQLK QSQVVFVLTG DCGDRTHPGY LAYEEIAATS SGQVFHLDKQ QVTEVLKWVE SAIQASKVHL LSTDHEEEGE HTWRLPFDPS LKEVTISLSG PGPEIEVQDP LGRILQEDEG LNVLLNIPDS AKVVAFKPEH PGLWSIKVYS SGRHSVRITG VSNIDFRAGF STQPLLDLNH TLEWPLQGVP ISLVINSTGL KAPGRLDSVE LAQSSGKPLL TLPTKPLSNG STHQLWGGPP FHTPKERFYL KVKGKDHEGN PLLRVSGVSY SGVAPGAPLV SMAPRIHGYL HQPLLVSCSV HSALPFRLQL RRGEARLGEE RHFQESGNSS WEILRASKAE EGTYECTAVS RAGTGRAKAQ IVVTDPPPQL VPAPNVTVSP GETAVLSCRV LGEAPYNLTW VRDWRVLPAS TGRVAQLADL SLEISGIIPT DGGRYQCVAS NANGVTRASV WLLVREAPQV SIHTSSQHFS QGVEVKVSCS ASGYPTPHIS WSRESQALQE DSRIHVDAQG TLIIQGVAPE DAGNYSCQAT NEVGTDQETV TLYYTDPPSV SAVNAVVLVA VGEEAVLVCE ASGVPPPRVI WYRGGLEMIL APEGSSSGKL RIPAAQERDA GTYTCRAVNE LGDASAEIQL AVGHAPQLTE LPRDVTVELG RSALLACRAT GRPPPTVTWR RGDGQPLGLR LGAGRGSRSR QPDSGVLFFE SVAPEDQAPY VCEARNVFGK VQAEARLIVT GHAPPQIASS APTVRVLEGQ PVSLPCIVLA GRPLPERHWL KDGRPLPPGS RHSIRADGSL HLDRALQEHA GRYSCVATNT AGSQHRDVEL VVQVPPRIHP TATHHITNEG VAASLPCVAS GVPAPTITWT KETNALTSRG PHYNVSKEGT LLIAQPSAQD AGAYVCTATN TVGFSSQEMR LSVNTKPRIH MNGSRNADVP LQVTAKAGEE VTLDCEAKGS PPPLVTWTKD SRPVPPITNR YGLLPSGSLR LAQVQVGDSG HYECTASNPA GSASHRYVLG VQVPPQVQPG PRVLKVLVGE ALDLNCVAEG NPEPQLSWSK DGVVLQGRGP QGSVHFAAIR TSDAGRYRCE ASNSAGVDAW EVELRVLEPP HWGADETSGL LERVAGENAS LPCPARGTPK PQVTWRKGPS SEPLHGQPGV AVLEEGSLFL ASVSPADSGD YECQATNEVG STSRRAKLVV YVPPSIREDG RKANVSGMAG QSLTLECDAN GFPVPEIVWL KDAQLIPKVG GHRLLDEGQS LHFPRIQEGD SGLYSCRAEN QAGTAQRDFH LLVLTPPSVL GAGAAQEVLG LAGADVELQC WTSGVPTPQV EWTKDRQPVL PGGPHLQVQE DGQVLRITGS HVGDEGRYQC VAFSPAGQQA RDFQLRVHAP PTIWGSNETG EVAVMEDHLV QLLCEARGVP TPNITWFKDG ALLPTSTKVV YTRGGRQLQL GRAQSSDAGV YTCKASNAVG AAEKATRLDV YVPPTIEGAG GRPYVVKAVA GRPVALECVA RGHPSPTLSW HHEGLPVAES NESRLETDGS VLRLESPGEA SSGLYSCVAS SPAGEAVLQY SVEVQVPPQL LVAEGLGQVT TIVGQPLELP CQASGSPVPT IQWLQNGRPA EELAGVQVAS QGTTLHIDHV ELDHSGLFAC QATNEAGTAG AEVEVSVHEF PSVSIIGGEN ITAPFLQPVT LQCIGDGVPT PSLRWWKDGV ALAAFGGNLQ IEKVDLRDEG IYTCAATNLA GESKREVALK VLVPPNIEPG PVNKAVLENA SVTLECLASG VPPPDVSWFK GHQPVSSWMG VTVSVDGRVL RIEQAQLSDA GSYRCVASNV AGSTELRYGL RVNVPPRITL PPSLPGPVLV NTPVRLTCNA TGAPSPTLMW LKDGNPVSPA GTPGLQVFPG GRVLTLASAR ASDSGRYSCV AVSAVGEDRQ DVVLQVHMPP SILGEELNVS VVANESVALE CQSHAMPPPV LSWWKDGRPL EPRPGVHLSA DKALLQVDRA DVWDAGHYTC EALNQAGHSE KHYNLNVWVA PVFPLRESHT LTVREGHPTR LSCECRGVPF PKISWRKDGQ PLPGEGAGLQ HVSAVGRLLY LGQAQLAQEG TYTCECSNVV GNSSQDLQLE VHVPPQIAGP REPPTQVSVV QDGVATLECN ATGKPPPTVT WERDGQPVGA ELGLQLQNQG QSLHVERAQA AHTGRYSCVA ENLAGRAERK FELSVLVPPE LIGDLDPLTN ITAALHSPLT LLCEAMGIPP PAIRWFRGEE PVSPGEDTYL LAGGWMLKMT QTQEQDSGLY SCLASNEAGE ARRNFSVEVL VPPSIENEDL EEVIKVLDGQ TAHLMCNVTG HPQPKLTWFK DGRPLARGDA HHISPDGVLL QVLQANLSSA GHYSCIAANA VGEKTKHFQL SVLLAPTILG GAEDSADEEV TVTVNNPISL ICEALAFPSP NITWMKDGAP FEASRNIQLL PGTHGLQILN AQKEDAGQYT CVVTNELGEA VKNYHVEVLI PPSISKDDPL AEVGVKEVKT KVNSTLTLEC ESWAVPPPTI RWYKDGQPVT PSSRLQVLGE GRLLQIQPTQ VSDSGRYLCV ATNVAGEDDQ DFNVLIQVPP MFQKVGDFSA AFEILSREEE ARGGVTEYRE IVENNPAYLY CDTNAIPPPD LTWYREDQPL SAGDEVSVLQ GGRVLQIPLV RAENAGRYSC KASNEVGEDW LHYELLVLTP PVILGDTEEL VEEVTVNASS TVSLQCPALG NPVPTISWLQ NGLPFSPSPR LQVLEDGQVL QVSTAEVADA ASYMCVAENQ AGSAEKLFTL RVQVPPRIAG LDLEQVTAIL NSSVSLPCDV HAHPNPEVTW YKDSQALSLG EEVFLLPGTH TLQLGRARLS DSGMYTCEAL NAAGRDQKLV QLSVLVPPAF RQAPRGPQDA VLVRVGDKAV LSCETDALPE PTVTWYKDGQ PLVLAQRTQA LRGGQRLEIQ EAQVSDKGLY SCKVSNVAGE AVRTFTLTVQ VPPTFENPKT ETVSQVAGSP LVLTCDVSGV PAPTVTWLKD RMPVESSAVH GVVSRGGRLQ LSRLQPAQAG TYTCVAENTQ AEARKDFVVA VLVAPRIRSS GVAREHHVLE GQEVRLDCEA DGQPPPDVAW LKDGSPLGQD MGPHLRFYLD GGSLVLKGLR ASDAGAYTCV AHNPAGEDAR LHTVNVLVPP TIKQGADGSG TLVSRPGELV TMVCPVRGSP PIHVSWLKDG LPLPLSQRTL LHGSGHTLRI SKVQLADAGI FTCVAASPAG VADRNFTLQV QVPPVLEPVE FQNDVVVVRG SLVELPCEAR GVPLPLVSWM KDGEPLLSQS LEQGPSLQLE AVGAGDSGTY SCVAVSEAGE ARRHFQLTVM EPPHIEDSGQ PTELSLTPGA PMELLCDAQG TPQPNITWHK DGQALTRLEN NSRATRVLRV ENVQVRDAGL YTCLAESPAG AIEKSFRVRV QAPPNIVGPR GPRFVVGLAP GQLVLECSVE AEPAPKITWH RDGIVLQEDA HTQFPERGRF LQLQALSTAD SGDYSCTARN AAGSTSVAFR VEIHTVPTIR SGPPAVNVSV NQTALLPCQA DGVPAPLVSW RKDRVPLDPR SPRFEILPEG SLRIQPVLAQ DAGHYLCLAS NSAGSDRQGR DLRVLEPPAI APSPSNLTLT AHTPALLPCE ASGSPKPLVV WWKDGQKLDF RLQQGAYRLL PSNALLLTAP GPQDSAQFEC VVSNEVGEAH RLYQVTVHVP PTIADDQTDF TVTMMAPVVL TCHSTGIPAP TVSWSKAGAQ LGARGSGYRV SPSGALEIGQ ALPIHAGRYT CSARNSAGVA HKHVFLTVQA SPVVKPLPSV VRAVAEEEVL LPCEASGIPR PTITWQKEGL NVATGVSTQV LPGGQLRIAH ASPEDAGNYL CIAKNSAGSA MGKTRLVVQV PPVIENGLPD LSTTEGSHAF LPCKARGSPE PNITWDKDGQ PVSGAEGKFT IQPSGELLVK NLEGQDAGTY TCTAENAVGR ARRRVHLTIL VLPVFTTLPG DRSLRLGDRL WLRCAARGSP TPRIGWTVND RPVTEGVSEQ DGGSTLQRAA VSREDSGTYV CWAENRVGRT QAVSFVHVKE APVLQGEAFS YLVEPVGGSI QLDCVVRGDP VPDIHWIKDG LPLRGSHLRH QLQNGSLTIR RTERDDAGRY QCLAENEMGV AKKVVILVLQ SAPVFQVEPQ DMTVRSGDDV ALRCQATGEP TPTIEWLQAG QPLRASRRLR TLPDGSLWLE NVETGDAGTY DCVAHNLLGS ATARAFLVVR GEPQGSWGSM TGVINGRKFG VATLNTSVMQ EAHSGVSSIH SSIRHVPANV GPLMRVLVVT IAPIYWALAR ESGEALNGHS LTGGRFRQES HVEFATGELL TMTQVARGLD PDGLLLLDVV VNGVVPESLA DADLQVQDFE EHYVQTGPGQ LFVGSTQRFF QGGLPSFLRC NHSIQYNAAR GPQPQLVQHL RASAISSAFD PEAEALRFQL ATALQAEENE VGCPEGFELD SQGAFCVDRD ECSGGPSPCS HACLNAPGRF SCTCPTGFAL AWDDRNCRDV DECAWDAHLC REGQRCVNLL GSYRCLPDCG PGFRVADGAG CEDVDECLEG LDDCHYNQLC ENTPGGHRCS CPRGYRMQGP SLPCLDVNEC LQLPKACAYQ CHNLQGSYRC LCPPGQTLLR DGKACTSLER NGQNVTTVSH RGPLLPWLRP WASIPGTSYH AWVSLRPGPM ALSSVGRAWC PPGFIRQNGV CTDLDECRVR NLCQHACRNT EGSYQCLCPA GYRLLPSGKN CQDINECEEE SIECGPGQMC FNTRGSYQCV DTPCPATYRQ GPSPGTCFRR CSQDCGTGGP STLQYRLLPL PLGVRAHHDV ARLTAFSEVG VPANRTELSM LEPDPRSPFA LRPLRAGLGA VYTRRALTRA GLYRLTVRAA APRHQSVFVL LIAVSPYPY //