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Q8NDA2

- HMCN2_HUMAN

UniProt

Q8NDA2 - HMCN2_HUMAN

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Protein

Hemicentin-2

Gene
HMCN2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. response to stimulus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Sensory transduction

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Hemicentin-2
Gene namesi
Name:HMCN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:21293. HMCN2.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671680.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 50655042Hemicentin-2PRO_0000395108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi329 – 3291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi346 – 3461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi379 – 3791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi478 – 4781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi525 – 5251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi538 ↔ 587 By similarity
Glycosylationi547 – 5471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi629 ↔ 677 By similarity
Glycosylationi674 – 6741N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi719 ↔ 765 By similarity
Disulfide bondi807 ↔ 862 By similarity
Disulfide bondi906 ↔ 955 By similarity
Disulfide bondi997 ↔ 1046 By similarity
Glycosylationi1024 – 10241N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1141 ↔ 1184 By similarity
Glycosylationi1223 – 12231N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1228 ↔ 1278 By similarity
Glycosylationi1309 – 13091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1322 ↔ 1386 By similarity
Disulfide bondi1430 ↔ 1480 By similarity
Glycosylationi1507 – 15071N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1524 ↔ 1573 By similarity
Glycosylationi1533 – 15331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1618 ↔ 1667 By similarity
Glycosylationi1641 – 16411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1711 ↔ 1760 By similarity
Disulfide bondi1807 ↔ 1865 By similarity
Glycosylationi1900 – 19001N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1907 ↔ 1956 By similarity
Disulfide bondi1999 ↔ 2050 By similarity
Glycosylationi2000 – 20001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2079 – 20791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2085 – 20851N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2092 ↔ 2141 By similarity
Disulfide bondi2184 ↔ 2235 By similarity
Glycosylationi2243 – 22431N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2280 ↔ 2329 By similarity
Glycosylationi2281 – 22811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2361 – 23611N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2374 ↔ 2423 By similarity
Glycosylationi2435 – 24351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2467 ↔ 2516 By similarity
Glycosylationi2468 – 24681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2507 – 25071N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2563 ↔ 2612 By similarity
Glycosylationi2572 – 25721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2654 – 26541N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2661 ↔ 2710 By similarity
Disulfide bondi2772 ↔ 2821 By similarity
Glycosylationi2858 – 28581N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2867 ↔ 2916 By similarity
Glycosylationi2952 – 29521N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2959 ↔ 3008 By similarity
Disulfide bondi3054 ↔ 3103 By similarity
Disulfide bondi3146 ↔ 3195 By similarity
Disulfide bondi3239 ↔ 3290 By similarity
Disulfide bondi3335 ↔ 3384 By similarity
Glycosylationi3396 – 33961N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3428 ↔ 3473 By similarity
Disulfide bondi3517 ↔ 3559 By similarity
Glycosylationi3526 – 35261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3541 – 35411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3603 ↔ 3652 By similarity
Glycosylationi3683 – 36831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3687 – 36871N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3694 ↔ 3743 By similarity
Glycosylationi3772 – 37721N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3785 ↔ 3836 By similarity
Disulfide bondi3878 ↔ 3927 By similarity
Disulfide bondi3969 ↔ 4017 By similarity
Disulfide bondi4059 ↔ 4108 By similarity
Glycosylationi4068 – 40681N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4150 ↔ 4197 By similarity
Disulfide bondi4240 ↔ 4288 By similarity
Glycosylationi4270 – 42701N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4330 ↔ 4378 By similarity
Glycosylationi4421 – 44211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4567 – 45671N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4638 ↔ 4649 By similarity
Disulfide bondi4645 ↔ 4658 By similarity
Disulfide bondi4660 ↔ 4673 By similarity
Disulfide bondi4679 ↔ 4692 By similarity
Disulfide bondi4686 ↔ 4701 By similarity
Disulfide bondi4705 ↔ 4717 By similarity
Disulfide bondi4723 ↔ 4736 By similarity
Disulfide bondi4730 ↔ 4745 By similarity
Disulfide bondi4766 ↔ 4777 By similarity
Disulfide bondi4773 ↔ 4786 By similarity
Disulfide bondi4788 ↔ 4801 By similarity
Glycosylationi4810 – 48101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4873 ↔ 4883 By similarity
Disulfide bondi4879 ↔ 4892 By similarity
Disulfide bondi4894 ↔ 4907 By similarity
Glycosylationi5000 – 50001N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NDA2.
PRIDEiQ8NDA2.

PTM databases

PhosphoSiteiQ8NDA2.

Expressioni

Gene expression databases

ArrayExpressiQ8NDA2.
BgeeiQ8NDA2.

Organism-specific databases

HPAiHPA053903.
HPA060387.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000277491.

Structurei

3D structure databases

ProteinModelPortaliQ8NDA2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 210175VWFAAdd
BLAST
Domaini518 – 60386Ig-like C2-type 1Add
BLAST
Domaini608 – 69184Ig-like C2-type 2Add
BLAST
Domaini698 – 78184Ig-like C2-type 3Add
BLAST
Domaini786 – 88095Ig-like C2-type 4Add
BLAST
Domaini885 – 97187Ig-like C2-type 5Add
BLAST
Domaini976 – 106287Ig-like C2-type 6Add
BLAST
Domaini1039 – 111577Ig-like C2-type 7Add
BLAST
Domaini1120 – 120081Ig-like C2-type 8Add
BLAST
Domaini1207 – 129488Ig-like C2-type 9Add
BLAST
Domaini1299 – 1400102Ig-like C2-type 10Add
BLAST
Domaini1407 – 149690Ig-like C2-type 11Add
BLAST
Domaini1501 – 158989Ig-like C2-type 12Add
BLAST
Domaini1594 – 168592Ig-like C2-type 13Add
BLAST
Domaini1688 – 177689Ig-like C2-type 14Add
BLAST
Domaini1783 – 187997Ig-like C2-type 15Add
BLAST
Domaini1886 – 197489Ig-like C2-type 16Add
BLAST
Domaini1977 – 206690Ig-like C2-type 17Add
BLAST
Domaini2071 – 215787Ig-like C2-type 18Add
BLAST
Domaini2162 – 225392Ig-like C2-type 19Add
BLAST
Domaini2256 – 234590Ig-like C2-type 20Add
BLAST
Domaini2350 – 243990Ig-like C2-type 21Add
BLAST
Domaini2444 – 253289Ig-like C2-type 22Add
BLAST
Domaini2537 – 262892Ig-like C2-type 23Add
BLAST
Domaini2633 – 272492Ig-like C2-type 24Add
BLAST
Domaini2731 – 2837107Ig-like C2-type 25Add
BLAST
Domaini2841 – 293090Ig-like C2-type 26Add
BLAST
Domaini2937 – 302488Ig-like C2-type 27Add
BLAST
Domaini3029 – 311991Ig-like C2-type 28Add
BLAST
Domaini3123 – 321189Ig-like C2-type 29Add
BLAST
Domaini3216 – 330691Ig-like C2-type 30Add
BLAST
Domaini3311 – 339888Ig-like C2-type 31Add
BLAST
Domaini3404 – 348986Ig-like C2-type 32Add
BLAST
Domaini3494 – 357582Ig-like C2-type 33Add
BLAST
Domaini3580 – 366889Ig-like C2-type 34Add
BLAST
Domaini3673 – 375987Ig-like C2-type 35Add
BLAST
Domaini3764 – 385491Ig-like C2-type 36Add
BLAST
Domaini3857 – 394387Ig-like C2-type 37Add
BLAST
Domaini3948 – 403386Ig-like C2-type 38Add
BLAST
Domaini4037 – 412488Ig-like C2-type 39Add
BLAST
Domaini4129 – 421082Ig-like C2-type 40Add
BLAST
Domaini4218 – 430184Ig-like C2-type 41Add
BLAST
Domaini4309 – 439486Ig-like C2-type 42Add
BLAST
Domaini4398 – 4620223Nidogen G2 beta-barrelAdd
BLAST
Domaini4634 – 467441EGF-like 1; calcium-binding Reviewed predictionAdd
BLAST
Domaini4675 – 471844EGF-like 2; calcium-binding Reviewed predictionAdd
BLAST
Domaini4719 – 475739EGF-like 3; calcium-binding Reviewed predictionAdd
BLAST
Domaini4762 – 480241EGF-like 4; calcium-binding Reviewed predictionAdd
BLAST
Domaini4869 – 490840EGF-like 5; calcium-binding Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 5 EGF-like domains.
Contains 1 VWFA domain.

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000172035.
HOVERGENiHBG073398.
OrthoDBiEOG78D7KD.
PhylomeDBiQ8NDA2.

Family and domain databases

Gene3Di2.40.155.10. 1 hit.
2.60.40.10. 42 hits.
InterProiIPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR006605. G2_nidogen/fibulin_G2F.
IPR009017. GFP.
IPR023413. GFP_like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002035. VWF_A.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 4 hits.
PF07474. G2F. 1 hit.
PF07679. I-set. 39 hits.
[Graphical view]
SMARTiSM00179. EGF_CA. 6 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 40 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF54511. SSF54511. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 5 hits.
PS50835. IG_LIKE. 40 hits.
PS50993. NIDOGEN_G2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NDA2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MMPGAPLLRL LTAVSAAVAV AVAGAPGTVM PPTTGDATLA FVFDVTGSMW     50
DELMQVIDGA SRILERSLSR RSQAIANYAL VPFHDPDIGP VTLTADPTVF 100
QRELRELYVQ GGGDCPEMSV GAIKAAVEVA NPGSFIYVFS DARAKDYHKK 150
EELLRLLQLK QSQVVFVLTG DCGDRTHPGY LAYEEIAATS SGQVFHLDKQ 200
QVTEVLKWVE SAIQASKVHL LSTDHEEEGE HTWRLPFDPS LKEVTISLSG 250
PGPEIEVQDP LGRILQEDEG LNVLLNIPDS AKVVAFKPEH PGLWSIKVYS 300
SGRHSVRITG VSNIDFRAGF STQPLLDLNH TLEWPLQGVP ISLVINSTGL 350
KAPGRLDSVE LAQSSGKPLL TLPTKPLSNG STHQLWGGPP FHTPKERFYL 400
KVKGKDHEGN PLLRVSGVSY SGVAPGAPLV SMAPRIHGYL HQPLLVSCSV 450
HSALPFRLQL RRGEARLGEE RHFQESGNSS WEILRASKAE EGTYECTAVS 500
RAGTGRAKAQ IVVTDPPPQL VPAPNVTVSP GETAVLSCRV LGEAPYNLTW 550
VRDWRVLPAS TGRVAQLADL SLEISGIIPT DGGRYQCVAS NANGVTRASV 600
WLLVREAPQV SIHTSSQHFS QGVEVKVSCS ASGYPTPHIS WSRESQALQE 650
DSRIHVDAQG TLIIQGVAPE DAGNYSCQAT NEVGTDQETV TLYYTDPPSV 700
SAVNAVVLVA VGEEAVLVCE ASGVPPPRVI WYRGGLEMIL APEGSSSGKL 750
RIPAAQERDA GTYTCRAVNE LGDASAEIQL AVGHAPQLTE LPRDVTVELG 800
RSALLACRAT GRPPPTVTWR RGDGQPLGLR LGAGRGSRSR QPDSGVLFFE 850
SVAPEDQAPY VCEARNVFGK VQAEARLIVT GHAPPQIASS APTVRVLEGQ 900
PVSLPCIVLA GRPLPERHWL KDGRPLPPGS RHSIRADGSL HLDRALQEHA 950
GRYSCVATNT AGSQHRDVEL VVQVPPRIHP TATHHITNEG VPASLPCVAS 1000
GVPAPTITWT KETNALTSRG PHYNVSKEGT LLIAQPSAQD AGAYVCTATN 1050
TVGFSSQEMR LSVNRLALSK YVWEEYGLLP SGSLRLAQVQ VGDSGHYECT 1100
ASNPAGSASH RYVLGVQVPP QVQPGPRVLK VLVGEALDLN CVAEGNPEPQ 1150
LSWSKDGVVL QGRGPQGSVH FAAIRTSDAG RYRCEASNSA GVDAWEVELR 1200
VLEPPHWGAD ETSGLLERVA GENASLPCPA RGTPKPQVTW RKGPSSEPLH 1250
GQPGVAVLEE GSLFLASVSP ADSGDYECQA TNEVGSTSRR AKLVVYVPPS 1300
IREDGRKANV SGMAGQSLTL ECDANGFPVP EIVWLKDAQL VGVPLGWAGY 1350
GWDLGWGQVG GHRLLDEGQS LHFPRIQEGD SGLYSCRAEN QAGTAQRDFH 1400
LLVLTPPSVL GAGAAQEVLG LAGADVELQC WTSGVPTPQV EWTKDRQPVL 1450
PGGPHLQVQE DGQVLRITGS HVGDEGRYQC VAFSPAGQQA RDFQLRVHAP 1500
PTIWGSNETG EVAVMEDHLV QLLCEARGVP TPNITWFKDG ALLPTSTKVV 1550
YTRGGRQLQL GRAQSSDAGV YTCKASNAVG AAEKATRLDV YVPPTIEGAG 1600
GRPYVVKAVA GRPVALECVA RGHPSPTLSW HHEGLPVAES NESRLETDGS 1650
VLRLESPGEA SSGLYSCVAS SPAGEAVLQY SVEVQVPPQL LVAEGLGQVT 1700
TIVGQPLELP CQASGSPVPT IQWLQNGRPA EELAGVQVAS QGTTLHIDHV 1750
ELDHSGLFAC QATNEAGTAG AEVEVSVHGE WAPGVLEVPI GQYHWGXEHH 1800
SSFPAACDPP VHRGWGAHPK PPLVEGWCSP GSLWGEPTGI PVAYSLPPPL 1850
QIEKVDLRDE GIYTCAATNL AGESKREVAL KVLVPPNIEP GPVNKAVLEN 1900
ASVTLECLAS GVPPPDVSWF KGHQPVSSWM GVTVSVDGRV LRIEQAQLSD 1950
AGSYRCVASN VAGSTELRYG LRVNVPPRIT LPPSLPGPVL VNTPVRLTCN 2000
ATGAPSPTLM WLKDGNPVSP AGTPGLQVFP GGRVLTLASA RASDSGRYSC 2050
VAVSAVGEDR QDVVLQVHMP PSILGEELNV SVVANESVAL ECQSHAMPPP 2100
VLSWWKDGRP LEPRPGVHLS ADKALLQVDR ADVWDAGHYT CEALNQAGHS 2150
EKHYNLNVWV APVFPLRESH TLTVREGHPT SLSCECRGVP FPKISWRKDG 2200
QPLPGEGAGL QHVSAVGRLL YLGQAQLAQE GTYTCECSNV VGNSSQDLQL 2250
EVHVPPQIAG PREPPTQVSV VQDGVATLEC NATGKPPPTV TWERDGQPVG 2300
AELGLQLQNQ GQSLHVERAQ AAHTGRYSCV AENLAGRAER KFELSVLVPP 2350
ELIGDLDPLT NITAALHSPL TLLCEAMGIP PPAIRWFRGE EPVSPGEDTY 2400
LLAGGWMLKM TQTQEQDSGL YSCLASNEAG EARRNFSVEV LVPPSIENED 2450
LEEVIKVLDG QTAHLMCNVT GHPQPKLTWF KDGRPLARGD AHHISPDGVL 2500
LQVLQANLSS AGHYSCIAAN AVGEKTKHFQ LSVLLAPTIL GGAEDSADEE 2550
VTVTVNNPIS LICEALAFPS PNITWMKDGA PFEASRNIQL LPGTHGLQIL 2600
NAQKEDAGQY TCVVTNELGE AVKNYHVEVL IPPSISKDDP LGEVGVKEVK 2650
TKVNSTLTLE CESWAVPPPT IRWYKDGQPV TPSSRLQVLG EGRLLQIQPT 2700
QVSDSGRYLC VATNVAGEDD QDFNVLIQVP PMFQKVGDFS AAFEILSREE 2750
EARGGVTEYR EIVENNPAYL YCDTNAIPPP DLTWYREDQP LSAGDEVSVL 2800
QGGRVLQIPL VRAENAGRYS CKASNEVGED WLHYELLVLT PPVILGDTEE 2850
LVEEVTVNAS STVSLQCPAL GNPVPTISWL QNGLPFSPSP RLQVLEDGQV 2900
LQVSTAEVAD AASYMCVAEN QAGSAEKLFT LRVQVPPRIA GLDLEQVTAI 2950
LNSSVSLPCD VHAHPNPEVT WYKDSQALSL GEEVFLLPGT HTLQLGRARL 3000
SDSGMYTCEA LNAAGRDQKL VQLSVLVPPA FRQAPRGPQD AVLVRVGDKA 3050
VLSCETDALP EPTVTWYKDG QPLVLAQRTQ ALRGGQRLEI QEAQVSDKGL 3100
YSCKVSNVAG EAVRTFTLTV QVPPTFENPK TETVSQVAGS PLVLTCDVSG 3150
VPAPTVTWLK DRMPVESSAV HGVVSRGGRL QLSRLQPAQA GTYTCVAENT 3200
QAEARKDFVV AVLVAPRIRS SGVAREHHVL EGQEVRLDCE ADGQPPPDVA 3250
WLKDGSPLGQ DMGPHLRFYL DGGSLVLKGL RASDAGAYTC VAHNPAGEDA 3300
RLHTVNVLVP PTIKQGADGS GTLVSRPGEL VTMVCPVRGS PPIHVSWLKD 3350
GLPLPLSQRT LLHGSGHTLR ISKVQLADAG IFTCVAASPA GVADRNFTLQ 3400
VQVPPVLEPV EFQNDVVVVR GSLVELPCEA RGVPLPLVSW MKDGEPLLSQ 3450
SLEQGPSLQL EAVGAGDSGT YSCVAVSEAG EARRHFQLTV MEPPHIEDSG 3500
QPTELSLTPG APMELLCDAQ GTPQPNITWH KDGQALTRLE NNSRATRVLR 3550
VRDAGLYTCL AESPAGAIEK SFRVRVQAPP NIVGPRGPRF VVGLAPGQLV 3600
LECSVEAEPA PKITWHRDGI VLQEDAHTQF PERGRFLQLQ ALSTADSGDY 3650
SCTARNAAGS TSVAFRVEIH TVPTIRSGPP AVNVSVNQTA LLPCQADGVP 3700
APLVSWRKDR VPLDPRSPRF EILPEGSLRI QPVLAQDAGH YLCLASNSAG 3750
SDRQGRDLRV LEPPAIAPSP SNLTLTAHTP ALLPCEASGS PKPLVVWWKD 3800
GQKLDFRLQQ GAYRLLPSNA LLLTAPGPQD SAQFECVVSN EVGEAHRLYQ 3850
VTVHVPPTIA DDQTDFTVTM MAPVVLTCHS TGIPAPTVSW SKAGAQLGAR 3900
GSGYRVSPSG ALEIGQALPI HAGRYTCSAR NSAGVAHKHV FLTVQASPVV 3950
KPLPSVVRAV AEEEVLLPCE ASGIPRPTIT WQKEGLNVAT GVSTQVLPGG 4000
QLRIAHASPE DAGNYLCIAK NSAGSAMGKT RLVVQVPPVI ENGLPDLSTT 4050
EGSHAFLPCK ARGSPEPNIT WDKDGQPVSG AEGKFTIQPS GELLVKNLEG 4100
QDAGTYTCTA ENAVGRARRR VHLTILVLPV FTTLPGDRSL RLGDRLWLRC 4150
AARGSPTPRI GWTVNDRPVT EGVSEQDGGS TLQRAAVSRE DSGTYVCWAE 4200
NRVGRTQAVS FVHVKEAPVL QGEAFSYLVE PVGGSIQLDC VVRGDPVPDI 4250
HWIKDGLPLR GSHLRHQLQN GSLTIHRTER DDAGRYQCLA ENEMGVAKKV 4300
VILVLQSAPV FQVEPQDMTV RSGDDVALRC QATGEPTPTI EWLQAGQPLR 4350
ASRRLRTLPD GSLWLENVET GDAGTYDCVA HNLLGSATAR AFLVVRGEPQ 4400
GSWGSMTGVI NGRKFGVATL NTSVMQEAHS GVSSIHSSIR HVPANVGPLM 4450
RVLVVTIAPI YWALARESGE ALNGHSLTGG RFRQESHVEF ATGELLTMTQ 4500
VARGLDPDGL LLLDVVVNGV VPESLADADL QVQDFEEHYV QTGPGQLFVG 4550
STQRFFQGGL PSFLRCNHSI QYNAARGPQP QLVQHLRASA ISSAFDPEAE 4600
ALRFQLATAL QAEENEVGCP EGFELDSQGA FCVDRDECSG GPSPCSHACL 4650
NAPGRFSCTC PTGFALAWDD RNCRDVDECA WDAHLCREGQ RCVNLLGSYR 4700
CLPDCGPGFR VADGAGCEDV DECLEGLDDC HYNQLCENTP GGHRCSCPRG 4750
YRMQGPSLPC LDVNECLQLP KACAYQCHNL QGSYRCLCPP GQTLLRDGKA 4800
CTSLERNGQN VTTVSHRGPL LPWLRPWASI PGTSYHAWVS LRPGPMALSS 4850
VGRAWCPPGF IRQNGVCTDL DECRVRNLCQ HACRNTEGSY QCLCPAGYRL 4900
LPSGKNCQDI NECEEESIEC GPGQMCFNTR GSYQCVDTPC PATYRQGPSP 4950
GTCFRRCSQD CGTGGPSTLQ YRLLPLPLGV RAHHDVARLT AFSEVGVPAN 5000
RTELSMLEPD PRSPFALRPL RAGLGAVYTR RALTRAGLYR LTVRAAAPRH 5050
QSVFVLLIAV SPYPY 5065
Length:5,065
Mass (Da):542,605
Last modified:June 15, 2010 - v2
Checksum:i9819758773E9051E
GO
Isoform 2 (identifier: Q8NDA2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     4171-4198: EGVSEQDGGSTLQRAAVSREDSGTYVCW → GLGLLGMGGTESQDTGRLRREGRWGDPT
     4199-5065: Missing.

Note: No experimental confirmation available.

Show »
Length:4,198
Mass (Da):448,332
Checksum:iE5A1ACDF3CABD317
GO
Isoform 3 (identifier: Q8NDA2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3401-3440: VQVPPVLEPV...RGVPLPLVSW → CPLSWSRWSS...GAFPCLSCRG
     3550-3550: R → RVENVQ
     3762-3780: Missing.
     4398-4757: EPQGSWGSMT...PRGYRMQGPS → MGHPCLDLRGQRQDLLPMGIVWCLWETCP
     4761-4767: Missing.
     4771-5065: KACAYQCHNL...LLIAVSPYPY → TSSLCFITSPE

Note: No experimental confirmation available.

Show »
Length:4,427
Mass (Da):474,146
Checksum:i378B87433B805BF9
GO

Sequence cautioni

The sequence BAB85069.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC04201.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence EAW87931.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei3401 – 344040VQVPP…PLVSW → CPLSWSRWSSRMTWWWFVAP WWNSRARPGAFPCLSCRG in isoform 3. VSP_039364Add
BLAST
Alternative sequencei3550 – 35501R → RVENVQ in isoform 3. VSP_039365
Alternative sequencei3762 – 378019Missing in isoform 3. VSP_039366Add
BLAST
Alternative sequencei4171 – 419828EGVSE…TYVCW → GLGLLGMGGTESQDTGRLRR EGRWGDPT in isoform 2. VSP_039367Add
BLAST
Alternative sequencei4199 – 5065867Missing in isoform 2. VSP_039368Add
BLAST
Alternative sequencei4398 – 4757360EPQGS…MQGPS → MGHPCLDLRGQRQDLLPMGI VWCLWETCP in isoform 3. VSP_039369Add
BLAST
Alternative sequencei4761 – 47677Missing in isoform 3. VSP_039370
Alternative sequencei4771 – 5065295KACAY…SPYPY → TSSLCFITSPE in isoform 3. VSP_039371Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3281 – 32811R → W in CAD38854. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL354898 Genomic DNA. No translation available.
AL360004 Genomic DNA. No translation available.
CH471090 Genomic DNA. Translation: EAW87931.1. Sequence problems.
AK074396 mRNA. Translation: BAB85069.1. Different initiation.
AK093583 mRNA. Translation: BAC04201.1. Different initiation.
AL834139 mRNA. Translation: CAD38854.1.
UniGeneiHs.32194.
Hs.512559.

Genome annotation databases

EnsembliENST00000302481; ENSP00000305590; ENSG00000148357.
ENST00000597795; ENSP00000472503; ENSG00000269324.

Polymorphism databases

DMDMi298351848.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL354898 Genomic DNA. No translation available.
AL360004 Genomic DNA. No translation available.
CH471090 Genomic DNA. Translation: EAW87931.1 . Sequence problems.
AK074396 mRNA. Translation: BAB85069.1 . Different initiation.
AK093583 mRNA. Translation: BAC04201.1 . Different initiation.
AL834139 mRNA. Translation: CAD38854.1 .
UniGenei Hs.32194.
Hs.512559.

3D structure databases

ProteinModelPortali Q8NDA2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000277491.

PTM databases

PhosphoSitei Q8NDA2.

Polymorphism databases

DMDMi 298351848.

Proteomic databases

PaxDbi Q8NDA2.
PRIDEi Q8NDA2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302481 ; ENSP00000305590 ; ENSG00000148357 .
ENST00000597795 ; ENSP00000472503 ; ENSG00000269324 .

Organism-specific databases

GeneCardsi GC09P133029.
H-InvDB HIX0008467.
HGNCi HGNC:21293. HMCN2.
HPAi HPA053903.
HPA060387.
neXtProti NX_Q8NDA2.
PharmGKBi PA142671680.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000172035.
HOVERGENi HBG073398.
OrthoDBi EOG78D7KD.
PhylomeDBi Q8NDA2.

Miscellaneous databases

PROi Q8NDA2.

Gene expression databases

ArrayExpressi Q8NDA2.
Bgeei Q8NDA2.

Family and domain databases

Gene3Di 2.40.155.10. 1 hit.
2.60.40.10. 42 hits.
InterProi IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR006605. G2_nidogen/fibulin_G2F.
IPR009017. GFP.
IPR023413. GFP_like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF12662. cEGF. 1 hit.
PF07645. EGF_CA. 4 hits.
PF07474. G2F. 1 hit.
PF07679. I-set. 39 hits.
[Graphical view ]
SMARTi SM00179. EGF_CA. 6 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 40 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
SSF54511. SSF54511. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 5 hits.
PS50835. IG_LIKE. 40 hits.
PS50993. NIDOGEN_G2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3793-4508 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4762-5065 (ISOFORM 1).
    Tissue: Small intestine and Thymus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3088-5065 (ISOFORM 3).
    Tissue: Testis.

Entry informationi

Entry nameiHMCN2_HUMAN
AccessioniPrimary (citable) accession number: Q8NDA2
Secondary accession number(s): Q8N225, Q8TCI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: April 16, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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