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Q8NDA2

- HMCN2_HUMAN

UniProt

Q8NDA2 - HMCN2_HUMAN

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Protein

Hemicentin-2

Gene

HMCN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. response to stimulus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Sensory transduction

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Hemicentin-2
Gene namesi
Name:HMCN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:21293. HMCN2.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671680.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 50655042Hemicentin-2PRO_0000395108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi346 – 3461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi525 – 5251N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi538 ↔ 587By similarity
Glycosylationi547 – 5471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi629 ↔ 677By similarity
Glycosylationi674 – 6741N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi719 ↔ 765By similarity
Disulfide bondi807 ↔ 862By similarity
Disulfide bondi906 ↔ 955By similarity
Disulfide bondi997 ↔ 1046By similarity
Glycosylationi1024 – 10241N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1141 ↔ 1184By similarity
Glycosylationi1223 – 12231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1228 ↔ 1278By similarity
Glycosylationi1309 – 13091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1322 ↔ 1386By similarity
Disulfide bondi1430 ↔ 1480By similarity
Glycosylationi1507 – 15071N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1524 ↔ 1573By similarity
Glycosylationi1533 – 15331N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1618 ↔ 1667By similarity
Glycosylationi1641 – 16411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1711 ↔ 1760By similarity
Disulfide bondi1807 ↔ 1865By similarity
Glycosylationi1900 – 19001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1907 ↔ 1956By similarity
Disulfide bondi1999 ↔ 2050By similarity
Glycosylationi2000 – 20001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2079 – 20791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2085 – 20851N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2092 ↔ 2141By similarity
Disulfide bondi2184 ↔ 2235By similarity
Glycosylationi2243 – 22431N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2280 ↔ 2329By similarity
Glycosylationi2281 – 22811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2361 – 23611N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2374 ↔ 2423By similarity
Glycosylationi2435 – 24351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2467 ↔ 2516By similarity
Glycosylationi2468 – 24681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2507 – 25071N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2563 ↔ 2612By similarity
Glycosylationi2572 – 25721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2654 – 26541N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2661 ↔ 2710By similarity
Disulfide bondi2772 ↔ 2821By similarity
Glycosylationi2858 – 28581N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2867 ↔ 2916By similarity
Glycosylationi2952 – 29521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2959 ↔ 3008By similarity
Disulfide bondi3054 ↔ 3103By similarity
Disulfide bondi3146 ↔ 3195By similarity
Disulfide bondi3239 ↔ 3290By similarity
Disulfide bondi3335 ↔ 3384By similarity
Glycosylationi3396 – 33961N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi3428 ↔ 3473By similarity
Disulfide bondi3517 ↔ 3559By similarity
Glycosylationi3526 – 35261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3541 – 35411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi3603 ↔ 3652By similarity
Glycosylationi3683 – 36831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3687 – 36871N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi3694 ↔ 3743By similarity
Glycosylationi3772 – 37721N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi3785 ↔ 3836By similarity
Disulfide bondi3878 ↔ 3927By similarity
Disulfide bondi3969 ↔ 4017By similarity
Disulfide bondi4059 ↔ 4108By similarity
Glycosylationi4068 – 40681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi4150 ↔ 4197By similarity
Disulfide bondi4240 ↔ 4288By similarity
Glycosylationi4270 – 42701N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi4330 ↔ 4378By similarity
Glycosylationi4421 – 44211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4567 – 45671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi4638 ↔ 4649By similarity
Disulfide bondi4645 ↔ 4658By similarity
Disulfide bondi4660 ↔ 4673By similarity
Disulfide bondi4679 ↔ 4692By similarity
Disulfide bondi4686 ↔ 4701By similarity
Disulfide bondi4705 ↔ 4717By similarity
Disulfide bondi4723 ↔ 4736By similarity
Disulfide bondi4730 ↔ 4745By similarity
Disulfide bondi4766 ↔ 4777By similarity
Disulfide bondi4773 ↔ 4786By similarity
Disulfide bondi4788 ↔ 4801By similarity
Glycosylationi4810 – 48101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi4873 ↔ 4883By similarity
Disulfide bondi4879 ↔ 4892By similarity
Disulfide bondi4894 ↔ 4907By similarity
Glycosylationi5000 – 50001N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NDA2.
PRIDEiQ8NDA2.

PTM databases

PhosphoSiteiQ8NDA2.

Expressioni

Gene expression databases

BgeeiQ8NDA2.

Organism-specific databases

HPAiHPA053903.
HPA060387.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000277491.

Structurei

3D structure databases

ProteinModelPortaliQ8NDA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 210175VWFAAdd
BLAST
Domaini518 – 60386Ig-like C2-type 1Add
BLAST
Domaini608 – 69184Ig-like C2-type 2Add
BLAST
Domaini698 – 78184Ig-like C2-type 3Add
BLAST
Domaini786 – 88095Ig-like C2-type 4Add
BLAST
Domaini885 – 97187Ig-like C2-type 5Add
BLAST
Domaini976 – 106287Ig-like C2-type 6Add
BLAST
Domaini1039 – 111577Ig-like C2-type 7Add
BLAST
Domaini1120 – 120081Ig-like C2-type 8Add
BLAST
Domaini1207 – 129488Ig-like C2-type 9Add
BLAST
Domaini1299 – 1400102Ig-like C2-type 10Add
BLAST
Domaini1407 – 149690Ig-like C2-type 11Add
BLAST
Domaini1501 – 158989Ig-like C2-type 12Add
BLAST
Domaini1594 – 168592Ig-like C2-type 13Add
BLAST
Domaini1688 – 177689Ig-like C2-type 14Add
BLAST
Domaini1783 – 187997Ig-like C2-type 15Add
BLAST
Domaini1886 – 197489Ig-like C2-type 16Add
BLAST
Domaini1977 – 206690Ig-like C2-type 17Add
BLAST
Domaini2071 – 215787Ig-like C2-type 18Add
BLAST
Domaini2162 – 225392Ig-like C2-type 19Add
BLAST
Domaini2256 – 234590Ig-like C2-type 20Add
BLAST
Domaini2350 – 243990Ig-like C2-type 21Add
BLAST
Domaini2444 – 253289Ig-like C2-type 22Add
BLAST
Domaini2537 – 262892Ig-like C2-type 23Add
BLAST
Domaini2633 – 272492Ig-like C2-type 24Add
BLAST
Domaini2731 – 2837107Ig-like C2-type 25Add
BLAST
Domaini2841 – 293090Ig-like C2-type 26Add
BLAST
Domaini2937 – 302488Ig-like C2-type 27Add
BLAST
Domaini3029 – 311991Ig-like C2-type 28Add
BLAST
Domaini3123 – 321189Ig-like C2-type 29Add
BLAST
Domaini3216 – 330691Ig-like C2-type 30Add
BLAST
Domaini3311 – 339888Ig-like C2-type 31Add
BLAST
Domaini3404 – 348986Ig-like C2-type 32Add
BLAST
Domaini3494 – 357582Ig-like C2-type 33Add
BLAST
Domaini3580 – 366889Ig-like C2-type 34Add
BLAST
Domaini3673 – 375987Ig-like C2-type 35Add
BLAST
Domaini3764 – 385491Ig-like C2-type 36Add
BLAST
Domaini3857 – 394387Ig-like C2-type 37Add
BLAST
Domaini3948 – 403386Ig-like C2-type 38Add
BLAST
Domaini4037 – 412488Ig-like C2-type 39Add
BLAST
Domaini4129 – 421082Ig-like C2-type 40Add
BLAST
Domaini4218 – 430184Ig-like C2-type 41Add
BLAST
Domaini4309 – 439486Ig-like C2-type 42Add
BLAST
Domaini4398 – 4620223Nidogen G2 beta-barrelPROSITE-ProRule annotationAdd
BLAST
Domaini4634 – 467441EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini4675 – 471844EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini4719 – 475739EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini4762 – 480241EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini4869 – 490840EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 EGF-like domains.PROSITE-ProRule annotation
Contains 1 nidogen G2 beta-barrel domain.PROSITE-ProRule annotation
Contains 1 VWFA domain.Curated

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000172035.
HOVERGENiHBG073398.
InParanoidiQ8NDA2.
OrthoDBiEOG78D7KD.
PhylomeDBiQ8NDA2.

Family and domain databases

Gene3Di2.40.155.10. 1 hit.
2.60.40.10. 42 hits.
InterProiIPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR006605. G2_nidogen/fibulin_G2F.
IPR009017. GFP.
IPR023413. GFP_like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002035. VWF_A.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 4 hits.
PF07474. G2F. 1 hit.
PF07679. I-set. 39 hits.
[Graphical view]
SMARTiSM00179. EGF_CA. 6 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 40 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF54511. SSF54511. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 5 hits.
PS50835. IG_LIKE. 40 hits.
PS50993. NIDOGEN_G2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NDA2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MMPGAPLLRL LTAVSAAVAV AVAGAPGTVM PPTTGDATLA FVFDVTGSMW
60 70 80 90 100
DELMQVIDGA SRILERSLSR RSQAIANYAL VPFHDPDIGP VTLTADPTVF
110 120 130 140 150
QRELRELYVQ GGGDCPEMSV GAIKAAVEVA NPGSFIYVFS DARAKDYHKK
160 170 180 190 200
EELLRLLQLK QSQVVFVLTG DCGDRTHPGY LAYEEIAATS SGQVFHLDKQ
210 220 230 240 250
QVTEVLKWVE SAIQASKVHL LSTDHEEEGE HTWRLPFDPS LKEVTISLSG
260 270 280 290 300
PGPEIEVQDP LGRILQEDEG LNVLLNIPDS AKVVAFKPEH PGLWSIKVYS
310 320 330 340 350
SGRHSVRITG VSNIDFRAGF STQPLLDLNH TLEWPLQGVP ISLVINSTGL
360 370 380 390 400
KAPGRLDSVE LAQSSGKPLL TLPTKPLSNG STHQLWGGPP FHTPKERFYL
410 420 430 440 450
KVKGKDHEGN PLLRVSGVSY SGVAPGAPLV SMAPRIHGYL HQPLLVSCSV
460 470 480 490 500
HSALPFRLQL RRGEARLGEE RHFQESGNSS WEILRASKAE EGTYECTAVS
510 520 530 540 550
RAGTGRAKAQ IVVTDPPPQL VPAPNVTVSP GETAVLSCRV LGEAPYNLTW
560 570 580 590 600
VRDWRVLPAS TGRVAQLADL SLEISGIIPT DGGRYQCVAS NANGVTRASV
610 620 630 640 650
WLLVREAPQV SIHTSSQHFS QGVEVKVSCS ASGYPTPHIS WSRESQALQE
660 670 680 690 700
DSRIHVDAQG TLIIQGVAPE DAGNYSCQAT NEVGTDQETV TLYYTDPPSV
710 720 730 740 750
SAVNAVVLVA VGEEAVLVCE ASGVPPPRVI WYRGGLEMIL APEGSSSGKL
760 770 780 790 800
RIPAAQERDA GTYTCRAVNE LGDASAEIQL AVGHAPQLTE LPRDVTVELG
810 820 830 840 850
RSALLACRAT GRPPPTVTWR RGDGQPLGLR LGAGRGSRSR QPDSGVLFFE
860 870 880 890 900
SVAPEDQAPY VCEARNVFGK VQAEARLIVT GHAPPQIASS APTVRVLEGQ
910 920 930 940 950
PVSLPCIVLA GRPLPERHWL KDGRPLPPGS RHSIRADGSL HLDRALQEHA
960 970 980 990 1000
GRYSCVATNT AGSQHRDVEL VVQVPPRIHP TATHHITNEG VPASLPCVAS
1010 1020 1030 1040 1050
GVPAPTITWT KETNALTSRG PHYNVSKEGT LLIAQPSAQD AGAYVCTATN
1060 1070 1080 1090 1100
TVGFSSQEMR LSVNRLALSK YVWEEYGLLP SGSLRLAQVQ VGDSGHYECT
1110 1120 1130 1140 1150
ASNPAGSASH RYVLGVQVPP QVQPGPRVLK VLVGEALDLN CVAEGNPEPQ
1160 1170 1180 1190 1200
LSWSKDGVVL QGRGPQGSVH FAAIRTSDAG RYRCEASNSA GVDAWEVELR
1210 1220 1230 1240 1250
VLEPPHWGAD ETSGLLERVA GENASLPCPA RGTPKPQVTW RKGPSSEPLH
1260 1270 1280 1290 1300
GQPGVAVLEE GSLFLASVSP ADSGDYECQA TNEVGSTSRR AKLVVYVPPS
1310 1320 1330 1340 1350
IREDGRKANV SGMAGQSLTL ECDANGFPVP EIVWLKDAQL VGVPLGWAGY
1360 1370 1380 1390 1400
GWDLGWGQVG GHRLLDEGQS LHFPRIQEGD SGLYSCRAEN QAGTAQRDFH
1410 1420 1430 1440 1450
LLVLTPPSVL GAGAAQEVLG LAGADVELQC WTSGVPTPQV EWTKDRQPVL
1460 1470 1480 1490 1500
PGGPHLQVQE DGQVLRITGS HVGDEGRYQC VAFSPAGQQA RDFQLRVHAP
1510 1520 1530 1540 1550
PTIWGSNETG EVAVMEDHLV QLLCEARGVP TPNITWFKDG ALLPTSTKVV
1560 1570 1580 1590 1600
YTRGGRQLQL GRAQSSDAGV YTCKASNAVG AAEKATRLDV YVPPTIEGAG
1610 1620 1630 1640 1650
GRPYVVKAVA GRPVALECVA RGHPSPTLSW HHEGLPVAES NESRLETDGS
1660 1670 1680 1690 1700
VLRLESPGEA SSGLYSCVAS SPAGEAVLQY SVEVQVPPQL LVAEGLGQVT
1710 1720 1730 1740 1750
TIVGQPLELP CQASGSPVPT IQWLQNGRPA EELAGVQVAS QGTTLHIDHV
1760 1770 1780 1790 1800
ELDHSGLFAC QATNEAGTAG AEVEVSVHGE WAPGVLEVPI GQYHWGXEHH
1810 1820 1830 1840 1850
SSFPAACDPP VHRGWGAHPK PPLVEGWCSP GSLWGEPTGI PVAYSLPPPL
1860 1870 1880 1890 1900
QIEKVDLRDE GIYTCAATNL AGESKREVAL KVLVPPNIEP GPVNKAVLEN
1910 1920 1930 1940 1950
ASVTLECLAS GVPPPDVSWF KGHQPVSSWM GVTVSVDGRV LRIEQAQLSD
1960 1970 1980 1990 2000
AGSYRCVASN VAGSTELRYG LRVNVPPRIT LPPSLPGPVL VNTPVRLTCN
2010 2020 2030 2040 2050
ATGAPSPTLM WLKDGNPVSP AGTPGLQVFP GGRVLTLASA RASDSGRYSC
2060 2070 2080 2090 2100
VAVSAVGEDR QDVVLQVHMP PSILGEELNV SVVANESVAL ECQSHAMPPP
2110 2120 2130 2140 2150
VLSWWKDGRP LEPRPGVHLS ADKALLQVDR ADVWDAGHYT CEALNQAGHS
2160 2170 2180 2190 2200
EKHYNLNVWV APVFPLRESH TLTVREGHPT SLSCECRGVP FPKISWRKDG
2210 2220 2230 2240 2250
QPLPGEGAGL QHVSAVGRLL YLGQAQLAQE GTYTCECSNV VGNSSQDLQL
2260 2270 2280 2290 2300
EVHVPPQIAG PREPPTQVSV VQDGVATLEC NATGKPPPTV TWERDGQPVG
2310 2320 2330 2340 2350
AELGLQLQNQ GQSLHVERAQ AAHTGRYSCV AENLAGRAER KFELSVLVPP
2360 2370 2380 2390 2400
ELIGDLDPLT NITAALHSPL TLLCEAMGIP PPAIRWFRGE EPVSPGEDTY
2410 2420 2430 2440 2450
LLAGGWMLKM TQTQEQDSGL YSCLASNEAG EARRNFSVEV LVPPSIENED
2460 2470 2480 2490 2500
LEEVIKVLDG QTAHLMCNVT GHPQPKLTWF KDGRPLARGD AHHISPDGVL
2510 2520 2530 2540 2550
LQVLQANLSS AGHYSCIAAN AVGEKTKHFQ LSVLLAPTIL GGAEDSADEE
2560 2570 2580 2590 2600
VTVTVNNPIS LICEALAFPS PNITWMKDGA PFEASRNIQL LPGTHGLQIL
2610 2620 2630 2640 2650
NAQKEDAGQY TCVVTNELGE AVKNYHVEVL IPPSISKDDP LGEVGVKEVK
2660 2670 2680 2690 2700
TKVNSTLTLE CESWAVPPPT IRWYKDGQPV TPSSRLQVLG EGRLLQIQPT
2710 2720 2730 2740 2750
QVSDSGRYLC VATNVAGEDD QDFNVLIQVP PMFQKVGDFS AAFEILSREE
2760 2770 2780 2790 2800
EARGGVTEYR EIVENNPAYL YCDTNAIPPP DLTWYREDQP LSAGDEVSVL
2810 2820 2830 2840 2850
QGGRVLQIPL VRAENAGRYS CKASNEVGED WLHYELLVLT PPVILGDTEE
2860 2870 2880 2890 2900
LVEEVTVNAS STVSLQCPAL GNPVPTISWL QNGLPFSPSP RLQVLEDGQV
2910 2920 2930 2940 2950
LQVSTAEVAD AASYMCVAEN QAGSAEKLFT LRVQVPPRIA GLDLEQVTAI
2960 2970 2980 2990 3000
LNSSVSLPCD VHAHPNPEVT WYKDSQALSL GEEVFLLPGT HTLQLGRARL
3010 3020 3030 3040 3050
SDSGMYTCEA LNAAGRDQKL VQLSVLVPPA FRQAPRGPQD AVLVRVGDKA
3060 3070 3080 3090 3100
VLSCETDALP EPTVTWYKDG QPLVLAQRTQ ALRGGQRLEI QEAQVSDKGL
3110 3120 3130 3140 3150
YSCKVSNVAG EAVRTFTLTV QVPPTFENPK TETVSQVAGS PLVLTCDVSG
3160 3170 3180 3190 3200
VPAPTVTWLK DRMPVESSAV HGVVSRGGRL QLSRLQPAQA GTYTCVAENT
3210 3220 3230 3240 3250
QAEARKDFVV AVLVAPRIRS SGVAREHHVL EGQEVRLDCE ADGQPPPDVA
3260 3270 3280 3290 3300
WLKDGSPLGQ DMGPHLRFYL DGGSLVLKGL RASDAGAYTC VAHNPAGEDA
3310 3320 3330 3340 3350
RLHTVNVLVP PTIKQGADGS GTLVSRPGEL VTMVCPVRGS PPIHVSWLKD
3360 3370 3380 3390 3400
GLPLPLSQRT LLHGSGHTLR ISKVQLADAG IFTCVAASPA GVADRNFTLQ
3410 3420 3430 3440 3450
VQVPPVLEPV EFQNDVVVVR GSLVELPCEA RGVPLPLVSW MKDGEPLLSQ
3460 3470 3480 3490 3500
SLEQGPSLQL EAVGAGDSGT YSCVAVSEAG EARRHFQLTV MEPPHIEDSG
3510 3520 3530 3540 3550
QPTELSLTPG APMELLCDAQ GTPQPNITWH KDGQALTRLE NNSRATRVLR
3560 3570 3580 3590 3600
VRDAGLYTCL AESPAGAIEK SFRVRVQAPP NIVGPRGPRF VVGLAPGQLV
3610 3620 3630 3640 3650
LECSVEAEPA PKITWHRDGI VLQEDAHTQF PERGRFLQLQ ALSTADSGDY
3660 3670 3680 3690 3700
SCTARNAAGS TSVAFRVEIH TVPTIRSGPP AVNVSVNQTA LLPCQADGVP
3710 3720 3730 3740 3750
APLVSWRKDR VPLDPRSPRF EILPEGSLRI QPVLAQDAGH YLCLASNSAG
3760 3770 3780 3790 3800
SDRQGRDLRV LEPPAIAPSP SNLTLTAHTP ALLPCEASGS PKPLVVWWKD
3810 3820 3830 3840 3850
GQKLDFRLQQ GAYRLLPSNA LLLTAPGPQD SAQFECVVSN EVGEAHRLYQ
3860 3870 3880 3890 3900
VTVHVPPTIA DDQTDFTVTM MAPVVLTCHS TGIPAPTVSW SKAGAQLGAR
3910 3920 3930 3940 3950
GSGYRVSPSG ALEIGQALPI HAGRYTCSAR NSAGVAHKHV FLTVQASPVV
3960 3970 3980 3990 4000
KPLPSVVRAV AEEEVLLPCE ASGIPRPTIT WQKEGLNVAT GVSTQVLPGG
4010 4020 4030 4040 4050
QLRIAHASPE DAGNYLCIAK NSAGSAMGKT RLVVQVPPVI ENGLPDLSTT
4060 4070 4080 4090 4100
EGSHAFLPCK ARGSPEPNIT WDKDGQPVSG AEGKFTIQPS GELLVKNLEG
4110 4120 4130 4140 4150
QDAGTYTCTA ENAVGRARRR VHLTILVLPV FTTLPGDRSL RLGDRLWLRC
4160 4170 4180 4190 4200
AARGSPTPRI GWTVNDRPVT EGVSEQDGGS TLQRAAVSRE DSGTYVCWAE
4210 4220 4230 4240 4250
NRVGRTQAVS FVHVKEAPVL QGEAFSYLVE PVGGSIQLDC VVRGDPVPDI
4260 4270 4280 4290 4300
HWIKDGLPLR GSHLRHQLQN GSLTIHRTER DDAGRYQCLA ENEMGVAKKV
4310 4320 4330 4340 4350
VILVLQSAPV FQVEPQDMTV RSGDDVALRC QATGEPTPTI EWLQAGQPLR
4360 4370 4380 4390 4400
ASRRLRTLPD GSLWLENVET GDAGTYDCVA HNLLGSATAR AFLVVRGEPQ
4410 4420 4430 4440 4450
GSWGSMTGVI NGRKFGVATL NTSVMQEAHS GVSSIHSSIR HVPANVGPLM
4460 4470 4480 4490 4500
RVLVVTIAPI YWALARESGE ALNGHSLTGG RFRQESHVEF ATGELLTMTQ
4510 4520 4530 4540 4550
VARGLDPDGL LLLDVVVNGV VPESLADADL QVQDFEEHYV QTGPGQLFVG
4560 4570 4580 4590 4600
STQRFFQGGL PSFLRCNHSI QYNAARGPQP QLVQHLRASA ISSAFDPEAE
4610 4620 4630 4640 4650
ALRFQLATAL QAEENEVGCP EGFELDSQGA FCVDRDECSG GPSPCSHACL
4660 4670 4680 4690 4700
NAPGRFSCTC PTGFALAWDD RNCRDVDECA WDAHLCREGQ RCVNLLGSYR
4710 4720 4730 4740 4750
CLPDCGPGFR VADGAGCEDV DECLEGLDDC HYNQLCENTP GGHRCSCPRG
4760 4770 4780 4790 4800
YRMQGPSLPC LDVNECLQLP KACAYQCHNL QGSYRCLCPP GQTLLRDGKA
4810 4820 4830 4840 4850
CTSLERNGQN VTTVSHRGPL LPWLRPWASI PGTSYHAWVS LRPGPMALSS
4860 4870 4880 4890 4900
VGRAWCPPGF IRQNGVCTDL DECRVRNLCQ HACRNTEGSY QCLCPAGYRL
4910 4920 4930 4940 4950
LPSGKNCQDI NECEEESIEC GPGQMCFNTR GSYQCVDTPC PATYRQGPSP
4960 4970 4980 4990 5000
GTCFRRCSQD CGTGGPSTLQ YRLLPLPLGV RAHHDVARLT AFSEVGVPAN
5010 5020 5030 5040 5050
RTELSMLEPD PRSPFALRPL RAGLGAVYTR RALTRAGLYR LTVRAAAPRH
5060
QSVFVLLIAV SPYPY
Length:5,065
Mass (Da):542,605
Last modified:June 15, 2010 - v2
Checksum:i9819758773E9051E
GO
Isoform 2 (identifier: Q8NDA2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     4171-4198: EGVSEQDGGSTLQRAAVSREDSGTYVCW → GLGLLGMGGTESQDTGRLRREGRWGDPT
     4199-5065: Missing.

Note: No experimental confirmation available.

Show »
Length:4,198
Mass (Da):448,332
Checksum:iE5A1ACDF3CABD317
GO
Isoform 3 (identifier: Q8NDA2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3401-3440: VQVPPVLEPV...RGVPLPLVSW → CPLSWSRWSS...GAFPCLSCRG
     3550-3550: R → RVENVQ
     3762-3780: Missing.
     4398-4757: EPQGSWGSMT...PRGYRMQGPS → MGHPCLDLRGQRQDLLPMGIVWCLWETCP
     4761-4767: Missing.
     4771-5065: KACAYQCHNL...LLIAVSPYPY → TSSLCFITSPE

Note: No experimental confirmation available.

Show »
Length:4,427
Mass (Da):474,146
Checksum:i378B87433B805BF9
GO

Sequence cautioni

The sequence BAB85069.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC04201.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW87931.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3281 – 32811R → W in CAD38854. (PubMed:17974005)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei3401 – 344040VQVPP…PLVSW → CPLSWSRWSSRMTWWWFVAP WWNSRARPGAFPCLSCRG in isoform 3. 1 PublicationVSP_039364Add
BLAST
Alternative sequencei3550 – 35501R → RVENVQ in isoform 3. 1 PublicationVSP_039365
Alternative sequencei3762 – 378019Missing in isoform 3. 1 PublicationVSP_039366Add
BLAST
Alternative sequencei4171 – 419828EGVSE…TYVCW → GLGLLGMGGTESQDTGRLRR EGRWGDPT in isoform 2. 1 PublicationVSP_039367Add
BLAST
Alternative sequencei4199 – 5065867Missing in isoform 2. 1 PublicationVSP_039368Add
BLAST
Alternative sequencei4398 – 4757360EPQGS…MQGPS → MGHPCLDLRGQRQDLLPMGI VWCLWETCP in isoform 3. 1 PublicationVSP_039369Add
BLAST
Alternative sequencei4761 – 47677Missing in isoform 3. 1 PublicationVSP_039370
Alternative sequencei4771 – 5065295KACAY…SPYPY → TSSLCFITSPE in isoform 3. 1 PublicationVSP_039371Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354898 Genomic DNA. No translation available.
AL360004 Genomic DNA. No translation available.
CH471090 Genomic DNA. Translation: EAW87931.1. Sequence problems.
AK074396 mRNA. Translation: BAB85069.1. Different initiation.
AK093583 mRNA. Translation: BAC04201.1. Different initiation.
AL834139 mRNA. Translation: CAD38854.1.
UniGeneiHs.32194.
Hs.512559.

Genome annotation databases

EnsembliENST00000302481; ENSP00000305590; ENSG00000148357.

Polymorphism databases

DMDMi298351848.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354898 Genomic DNA. No translation available.
AL360004 Genomic DNA. No translation available.
CH471090 Genomic DNA. Translation: EAW87931.1 . Sequence problems.
AK074396 mRNA. Translation: BAB85069.1 . Different initiation.
AK093583 mRNA. Translation: BAC04201.1 . Different initiation.
AL834139 mRNA. Translation: CAD38854.1 .
UniGenei Hs.32194.
Hs.512559.

3D structure databases

ProteinModelPortali Q8NDA2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000277491.

PTM databases

PhosphoSitei Q8NDA2.

Polymorphism databases

DMDMi 298351848.

Proteomic databases

PaxDbi Q8NDA2.
PRIDEi Q8NDA2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302481 ; ENSP00000305590 ; ENSG00000148357 .

Organism-specific databases

GeneCardsi GC09P133029.
H-InvDB HIX0008467.
HGNCi HGNC:21293. HMCN2.
HPAi HPA053903.
HPA060387.
neXtProti NX_Q8NDA2.
PharmGKBi PA142671680.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000172035.
HOVERGENi HBG073398.
InParanoidi Q8NDA2.
OrthoDBi EOG78D7KD.
PhylomeDBi Q8NDA2.

Miscellaneous databases

PROi Q8NDA2.

Gene expression databases

Bgeei Q8NDA2.

Family and domain databases

Gene3Di 2.40.155.10. 1 hit.
2.60.40.10. 42 hits.
InterProi IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR006605. G2_nidogen/fibulin_G2F.
IPR009017. GFP.
IPR023413. GFP_like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF12662. cEGF. 1 hit.
PF07645. EGF_CA. 4 hits.
PF07474. G2F. 1 hit.
PF07679. I-set. 39 hits.
[Graphical view ]
SMARTi SM00179. EGF_CA. 6 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 40 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
SSF54511. SSF54511. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 5 hits.
PS50835. IG_LIKE. 40 hits.
PS50993. NIDOGEN_G2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3793-4508 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4762-5065 (ISOFORM 1).
    Tissue: Small intestine and Thymus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3088-5065 (ISOFORM 3).
    Tissue: Testis.

Entry informationi

Entry nameiHMCN2_HUMAN
AccessioniPrimary (citable) accession number: Q8NDA2
Secondary accession number(s): Q8N225, Q8TCI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: October 29, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3