Q8NDA2 (HMCN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hemicentin-2

Gene names

Name:

HMCN2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	5065 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Sequence similarities	Contains 5 EGF-like domains. Contains 42 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 nidogen G2 beta-barrel domain. Contains 1 VWFA domain.
Sequence caution	The sequence BAB85069.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC04201.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence EAW87931.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Sensory transduction
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing
Domain	EGF-like domain Immunoglobulin domain Repeat Signal
Ligand	Calcium
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NDA2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NDA2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     4171-4198: EGVSEQDGGSTLQRAAVSREDSGTYVCW → GLGLLGMGGTESQDTGRLRREGRWGDPT
     4199-5065: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8NDA2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     3401-3440: VQVPPVLEPV...RGVPLPLVSW → CPLSWSRWSS...GAFPCLSCRG
     3550-3550: R → RVENVQ
     3762-3780: Missing.
     4398-4757: EPQGSWGSMT...PRGYRMQGPS → MGHPCLDLRGQRQDLLPMGIVWCLWETCP
     4761-4767: Missing.
     4771-5065: KACAYQCHNL...LLIAVSPYPY → TSSLCFITSPE

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 5065	5042	Hemicentin-2		PRO_0000395108
Regions
	Domain	36 – 210	175	VWFA
	Domain	518 – 603	86	Ig-like C2-type 1
	Domain	608 – 691	84	Ig-like C2-type 2
	Domain	698 – 781	84	Ig-like C2-type 3
	Domain	786 – 880	95	Ig-like C2-type 4
	Domain	885 – 971	87	Ig-like C2-type 5
	Domain	976 – 1062	87	Ig-like C2-type 6
	Domain	1039 – 1115	77	Ig-like C2-type 7
	Domain	1120 – 1200	81	Ig-like C2-type 8
	Domain	1207 – 1294	88	Ig-like C2-type 9
	Domain	1299 – 1400	102	Ig-like C2-type 10
	Domain	1407 – 1496	90	Ig-like C2-type 11
	Domain	1501 – 1589	89	Ig-like C2-type 12
	Domain	1594 – 1685	92	Ig-like C2-type 13
	Domain	1688 – 1776	89	Ig-like C2-type 14
	Domain	1783 – 1879	97	Ig-like C2-type 15
	Domain	1886 – 1974	89	Ig-like C2-type 16
	Domain	1977 – 2066	90	Ig-like C2-type 17
	Domain	2071 – 2157	87	Ig-like C2-type 18
	Domain	2162 – 2253	92	Ig-like C2-type 19
	Domain	2256 – 2345	90	Ig-like C2-type 20
	Domain	2350 – 2439	90	Ig-like C2-type 21
	Domain	2444 – 2532	89	Ig-like C2-type 22
	Domain	2537 – 2628	92	Ig-like C2-type 23
	Domain	2633 – 2724	92	Ig-like C2-type 24
	Domain	2731 – 2837	107	Ig-like C2-type 25
	Domain	2841 – 2930	90	Ig-like C2-type 26
	Domain	2937 – 3024	88	Ig-like C2-type 27
	Domain	3029 – 3119	91	Ig-like C2-type 28
	Domain	3123 – 3211	89	Ig-like C2-type 29
	Domain	3216 – 3306	91	Ig-like C2-type 30
	Domain	3311 – 3398	88	Ig-like C2-type 31
	Domain	3404 – 3489	86	Ig-like C2-type 32
	Domain	3494 – 3575	82	Ig-like C2-type 33
	Domain	3580 – 3668	89	Ig-like C2-type 34
	Domain	3673 – 3759	87	Ig-like C2-type 35
	Domain	3764 – 3854	91	Ig-like C2-type 36
	Domain	3857 – 3943	87	Ig-like C2-type 37
	Domain	3948 – 4033	86	Ig-like C2-type 38
	Domain	4037 – 4124	88	Ig-like C2-type 39
	Domain	4129 – 4210	82	Ig-like C2-type 40
	Domain	4218 – 4301	84	Ig-like C2-type 41
	Domain	4309 – 4394	86	Ig-like C2-type 42
	Domain	4398 – 4620	223	Nidogen G2 beta-barrel
	Domain	4634 – 4674	41	EGF-like 1; calcium-binding Potential
	Domain	4675 – 4718	44	EGF-like 2; calcium-binding Potential
	Domain	4719 – 4757	39	EGF-like 3; calcium-binding Potential
	Domain	4762 – 4802	41	EGF-like 4; calcium-binding Potential
	Domain	4869 – 4908	40	EGF-like 5; calcium-binding Potential
Amino acid modifications
	Modified residue	1874	1	Phosphoserine By similarity
	Glycosylation	329	1	N-linked (GlcNAc...) Potential
	Glycosylation	346	1	N-linked (GlcNAc...) Potential
	Glycosylation	379	1	N-linked (GlcNAc...) Potential
	Glycosylation	478	1	N-linked (GlcNAc...) Potential
	Glycosylation	525	1	N-linked (GlcNAc...) Potential
	Glycosylation	547	1	N-linked (GlcNAc...) Potential
	Glycosylation	674	1	N-linked (GlcNAc...) Potential
	Glycosylation	1024	1	N-linked (GlcNAc...) Potential
	Glycosylation	1223	1	N-linked (GlcNAc...) Potential
	Glycosylation	1309	1	N-linked (GlcNAc...) Potential
	Glycosylation	1507	1	N-linked (GlcNAc...) Potential
	Glycosylation	1533	1	N-linked (GlcNAc...) Potential
	Glycosylation	1641	1	N-linked (GlcNAc...) Potential
	Glycosylation	1900	1	N-linked (GlcNAc...) Potential
	Glycosylation	2000	1	N-linked (GlcNAc...) Potential
	Glycosylation	2079	1	N-linked (GlcNAc...) Potential
	Glycosylation	2085	1	N-linked (GlcNAc...) Potential
	Glycosylation	2243	1	N-linked (GlcNAc...) Potential
	Glycosylation	2281	1	N-linked (GlcNAc...) Potential
	Glycosylation	2361	1	N-linked (GlcNAc...) Potential
	Glycosylation	2435	1	N-linked (GlcNAc...) Potential
	Glycosylation	2468	1	N-linked (GlcNAc...) Potential
	Glycosylation	2507	1	N-linked (GlcNAc...) Potential
	Glycosylation	2572	1	N-linked (GlcNAc...) Potential
	Glycosylation	2654	1	N-linked (GlcNAc...) Potential
	Glycosylation	2858	1	N-linked (GlcNAc...) Potential
	Glycosylation	2952	1	N-linked (GlcNAc...) Potential
	Glycosylation	3396	1	N-linked (GlcNAc...) Potential
	Glycosylation	3526	1	N-linked (GlcNAc...) Potential
	Glycosylation	3541	1	N-linked (GlcNAc...) Potential
	Glycosylation	3683	1	N-linked (GlcNAc...) Potential
	Glycosylation	3687	1	N-linked (GlcNAc...) Potential
	Glycosylation	3772	1	N-linked (GlcNAc...) Potential
	Glycosylation	4068	1	N-linked (GlcNAc...) Potential
	Glycosylation	4270	1	N-linked (GlcNAc...) Potential
	Glycosylation	4421	1	N-linked (GlcNAc...) Potential
	Glycosylation	4567	1	N-linked (GlcNAc...) Potential
	Glycosylation	4810	1	N-linked (GlcNAc...) Potential
	Glycosylation	5000	1	N-linked (GlcNAc...) Potential
	Disulfide bond	538 ↔ 587		By similarity
	Disulfide bond	629 ↔ 677		By similarity
	Disulfide bond	719 ↔ 765		By similarity
	Disulfide bond	807 ↔ 862		By similarity
	Disulfide bond	906 ↔ 955		By similarity
	Disulfide bond	997 ↔ 1046		By similarity
	Disulfide bond	1141 ↔ 1184		By similarity
	Disulfide bond	1228 ↔ 1278		By similarity
	Disulfide bond	1322 ↔ 1386		By similarity
	Disulfide bond	1430 ↔ 1480		By similarity
	Disulfide bond	1524 ↔ 1573		By similarity
	Disulfide bond	1618 ↔ 1667		By similarity
	Disulfide bond	1711 ↔ 1760		By similarity
	Disulfide bond	1807 ↔ 1865		By similarity
	Disulfide bond	1907 ↔ 1956		By similarity
	Disulfide bond	1999 ↔ 2050		By similarity
	Disulfide bond	2092 ↔ 2141		By similarity
	Disulfide bond	2184 ↔ 2235		By similarity
	Disulfide bond	2280 ↔ 2329		By similarity
	Disulfide bond	2374 ↔ 2423		By similarity
	Disulfide bond	2467 ↔ 2516		By similarity
	Disulfide bond	2563 ↔ 2612		By similarity
	Disulfide bond	2661 ↔ 2710		By similarity
	Disulfide bond	2772 ↔ 2821		By similarity
	Disulfide bond	2867 ↔ 2916		By similarity
	Disulfide bond	2959 ↔ 3008		By similarity
	Disulfide bond	3054 ↔ 3103		By similarity
	Disulfide bond	3146 ↔ 3195		By similarity
	Disulfide bond	3239 ↔ 3290		By similarity
	Disulfide bond	3335 ↔ 3384		By similarity
	Disulfide bond	3428 ↔ 3473		By similarity
	Disulfide bond	3517 ↔ 3559		By similarity
	Disulfide bond	3603 ↔ 3652		By similarity
	Disulfide bond	3694 ↔ 3743		By similarity
	Disulfide bond	3785 ↔ 3836		By similarity
	Disulfide bond	3878 ↔ 3927		By similarity
	Disulfide bond	3969 ↔ 4017		By similarity
	Disulfide bond	4059 ↔ 4108		By similarity
	Disulfide bond	4150 ↔ 4197		By similarity
	Disulfide bond	4240 ↔ 4288		By similarity
	Disulfide bond	4330 ↔ 4378		By similarity
	Disulfide bond	4638 ↔ 4649		By similarity
	Disulfide bond	4645 ↔ 4658		By similarity
	Disulfide bond	4660 ↔ 4673		By similarity
	Disulfide bond	4679 ↔ 4692		By similarity
	Disulfide bond	4686 ↔ 4701		By similarity
	Disulfide bond	4705 ↔ 4717		By similarity
	Disulfide bond	4723 ↔ 4736		By similarity
	Disulfide bond	4730 ↔ 4745		By similarity
	Disulfide bond	4766 ↔ 4777		By similarity
	Disulfide bond	4773 ↔ 4786		By similarity
	Disulfide bond	4788 ↔ 4801		By similarity
	Disulfide bond	4873 ↔ 4883		By similarity
	Disulfide bond	4879 ↔ 4892		By similarity
	Disulfide bond	4894 ↔ 4907		By similarity
Natural variations
	Alternative sequence	3401 – 3440	40	VQVPP…PLVSW → CPLSWSRWSSRMTWWWFVAP WWNSRARPGAFPCLSCRG in isoform 3.		VSP_039364
	Alternative sequence	3550	1	R → RVENVQ in isoform 3.		VSP_039365
	Alternative sequence	3762 – 3780	19	Missing in isoform 3.		VSP_039366
	Alternative sequence	4171 – 4198	28	EGVSE…TYVCW → GLGLLGMGGTESQDTGRLRR EGRWGDPT in isoform 2.		VSP_039367
	Alternative sequence	4199 – 5065	867	Missing in isoform 2.		VSP_039368
	Alternative sequence	4398 – 4757	360	EPQGS…MQGPS → MGHPCLDLRGQRQDLLPMGI VWCLWETCP in isoform 3.		VSP_039369
	Alternative sequence	4761 – 4767	7	Missing in isoform 3.		VSP_039370
	Alternative sequence	4771 – 5065	295	KACAY…SPYPY → TSSLCFITSPE in isoform 3.		VSP_039371
Experimental info
	Sequence conflict	3281	1	R → W in CAD38854. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 15, 2010. Version 2. Checksum: 9819758773E9051E	FASTA	5,065	542,605
	10 20 30 40 50 60 MMPGAPLLRL LTAVSAAVAV AVAGAPGTVM PPTTGDATLA FVFDVTGSMW DELMQVIDGA 70 80 90 100 110 120 SRILERSLSR RSQAIANYAL VPFHDPDIGP VTLTADPTVF QRELRELYVQ GGGDCPEMSV 130 140 150 160 170 180 GAIKAAVEVA NPGSFIYVFS DARAKDYHKK EELLRLLQLK QSQVVFVLTG DCGDRTHPGY 190 200 210 220 230 240 LAYEEIAATS SGQVFHLDKQ QVTEVLKWVE SAIQASKVHL LSTDHEEEGE HTWRLPFDPS 250 260 270 280 290 300 LKEVTISLSG PGPEIEVQDP LGRILQEDEG LNVLLNIPDS AKVVAFKPEH PGLWSIKVYS 310 320 330 340 350 360 SGRHSVRITG VSNIDFRAGF STQPLLDLNH TLEWPLQGVP ISLVINSTGL KAPGRLDSVE 370 380 390 400 410 420 LAQSSGKPLL TLPTKPLSNG STHQLWGGPP FHTPKERFYL KVKGKDHEGN PLLRVSGVSY 430 440 450 460 470 480 SGVAPGAPLV SMAPRIHGYL HQPLLVSCSV HSALPFRLQL RRGEARLGEE RHFQESGNSS 490 500 510 520 530 540 WEILRASKAE EGTYECTAVS RAGTGRAKAQ IVVTDPPPQL VPAPNVTVSP GETAVLSCRV 550 560 570 580 590 600 LGEAPYNLTW VRDWRVLPAS TGRVAQLADL SLEISGIIPT DGGRYQCVAS NANGVTRASV 610 620 630 640 650 660 WLLVREAPQV SIHTSSQHFS QGVEVKVSCS ASGYPTPHIS WSRESQALQE DSRIHVDAQG 670 680 690 700 710 720 TLIIQGVAPE DAGNYSCQAT NEVGTDQETV TLYYTDPPSV SAVNAVVLVA VGEEAVLVCE 730 740 750 760 770 780 ASGVPPPRVI WYRGGLEMIL APEGSSSGKL RIPAAQERDA GTYTCRAVNE LGDASAEIQL 790 800 810 820 830 840 AVGHAPQLTE LPRDVTVELG RSALLACRAT GRPPPTVTWR RGDGQPLGLR LGAGRGSRSR 850 860 870 880 890 900 QPDSGVLFFE SVAPEDQAPY VCEARNVFGK VQAEARLIVT GHAPPQIASS APTVRVLEGQ 910 920 930 940 950 960 PVSLPCIVLA GRPLPERHWL KDGRPLPPGS RHSIRADGSL HLDRALQEHA GRYSCVATNT 970 980 990 1000 1010 1020 AGSQHRDVEL VVQVPPRIHP TATHHITNEG VPASLPCVAS GVPAPTITWT KETNALTSRG 1030 1040 1050 1060 1070 1080 PHYNVSKEGT LLIAQPSAQD AGAYVCTATN TVGFSSQEMR LSVNRLALSK YVWEEYGLLP 1090 1100 1110 1120 1130 1140 SGSLRLAQVQ VGDSGHYECT ASNPAGSASH RYVLGVQVPP QVQPGPRVLK VLVGEALDLN 1150 1160 1170 1180 1190 1200 CVAEGNPEPQ LSWSKDGVVL QGRGPQGSVH FAAIRTSDAG RYRCEASNSA GVDAWEVELR 1210 1220 1230 1240 1250 1260 VLEPPHWGAD ETSGLLERVA GENASLPCPA RGTPKPQVTW RKGPSSEPLH GQPGVAVLEE 1270 1280 1290 1300 1310 1320 GSLFLASVSP ADSGDYECQA TNEVGSTSRR AKLVVYVPPS IREDGRKANV SGMAGQSLTL 1330 1340 1350 1360 1370 1380 ECDANGFPVP EIVWLKDAQL VGVPLGWAGY GWDLGWGQVG GHRLLDEGQS LHFPRIQEGD 1390 1400 1410 1420 1430 1440 SGLYSCRAEN QAGTAQRDFH LLVLTPPSVL GAGAAQEVLG LAGADVELQC WTSGVPTPQV 1450 1460 1470 1480 1490 1500 EWTKDRQPVL PGGPHLQVQE DGQVLRITGS HVGDEGRYQC VAFSPAGQQA RDFQLRVHAP 1510 1520 1530 1540 1550 1560 PTIWGSNETG EVAVMEDHLV QLLCEARGVP TPNITWFKDG ALLPTSTKVV YTRGGRQLQL 1570 1580 1590 1600 1610 1620 GRAQSSDAGV YTCKASNAVG AAEKATRLDV YVPPTIEGAG GRPYVVKAVA GRPVALECVA 1630 1640 1650 1660 1670 1680 RGHPSPTLSW HHEGLPVAES NESRLETDGS VLRLESPGEA SSGLYSCVAS SPAGEAVLQY 1690 1700 1710 1720 1730 1740 SVEVQVPPQL LVAEGLGQVT TIVGQPLELP CQASGSPVPT IQWLQNGRPA EELAGVQVAS 1750 1760 1770 1780 1790 1800 QGTTLHIDHV ELDHSGLFAC QATNEAGTAG AEVEVSVHGE WAPGVLEVPI GQYHWGXEHH 1810 1820 1830 1840 1850 1860 SSFPAACDPP VHRGWGAHPK PPLVEGWCSP GSLWGEPTGI PVAYSLPPPL QIEKVDLRDE 1870 1880 1890 1900 1910 1920 GIYTCAATNL AGESKREVAL KVLVPPNIEP GPVNKAVLEN ASVTLECLAS GVPPPDVSWF 1930 1940 1950 1960 1970 1980 KGHQPVSSWM GVTVSVDGRV LRIEQAQLSD AGSYRCVASN VAGSTELRYG LRVNVPPRIT 1990 2000 2010 2020 2030 2040 LPPSLPGPVL VNTPVRLTCN ATGAPSPTLM WLKDGNPVSP AGTPGLQVFP GGRVLTLASA 2050 2060 2070 2080 2090 2100 RASDSGRYSC VAVSAVGEDR QDVVLQVHMP PSILGEELNV SVVANESVAL ECQSHAMPPP 2110 2120 2130 2140 2150 2160 VLSWWKDGRP LEPRPGVHLS ADKALLQVDR ADVWDAGHYT CEALNQAGHS EKHYNLNVWV 2170 2180 2190 2200 2210 2220 APVFPLRESH TLTVREGHPT SLSCECRGVP FPKISWRKDG QPLPGEGAGL QHVSAVGRLL 2230 2240 2250 2260 2270 2280 YLGQAQLAQE GTYTCECSNV VGNSSQDLQL EVHVPPQIAG PREPPTQVSV VQDGVATLEC 2290 2300 2310 2320 2330 2340 NATGKPPPTV TWERDGQPVG AELGLQLQNQ GQSLHVERAQ AAHTGRYSCV AENLAGRAER 2350 2360 2370 2380 2390 2400 KFELSVLVPP ELIGDLDPLT NITAALHSPL TLLCEAMGIP PPAIRWFRGE EPVSPGEDTY 2410 2420 2430 2440 2450 2460 LLAGGWMLKM TQTQEQDSGL YSCLASNEAG EARRNFSVEV LVPPSIENED LEEVIKVLDG 2470 2480 2490 2500 2510 2520 QTAHLMCNVT GHPQPKLTWF KDGRPLARGD AHHISPDGVL LQVLQANLSS AGHYSCIAAN 2530 2540 2550 2560 2570 2580 AVGEKTKHFQ LSVLLAPTIL GGAEDSADEE VTVTVNNPIS LICEALAFPS PNITWMKDGA 2590 2600 2610 2620 2630 2640 PFEASRNIQL LPGTHGLQIL NAQKEDAGQY TCVVTNELGE AVKNYHVEVL IPPSISKDDP 2650 2660 2670 2680 2690 2700 LGEVGVKEVK TKVNSTLTLE CESWAVPPPT IRWYKDGQPV TPSSRLQVLG EGRLLQIQPT 2710 2720 2730 2740 2750 2760 QVSDSGRYLC VATNVAGEDD QDFNVLIQVP PMFQKVGDFS AAFEILSREE EARGGVTEYR 2770 2780 2790 2800 2810 2820 EIVENNPAYL YCDTNAIPPP DLTWYREDQP LSAGDEVSVL QGGRVLQIPL VRAENAGRYS 2830 2840 2850 2860 2870 2880 CKASNEVGED WLHYELLVLT PPVILGDTEE LVEEVTVNAS STVSLQCPAL GNPVPTISWL 2890 2900 2910 2920 2930 2940 QNGLPFSPSP RLQVLEDGQV LQVSTAEVAD AASYMCVAEN QAGSAEKLFT LRVQVPPRIA 2950 2960 2970 2980 2990 3000 GLDLEQVTAI LNSSVSLPCD VHAHPNPEVT WYKDSQALSL GEEVFLLPGT HTLQLGRARL 3010 3020 3030 3040 3050 3060 SDSGMYTCEA LNAAGRDQKL VQLSVLVPPA FRQAPRGPQD AVLVRVGDKA VLSCETDALP 3070 3080 3090 3100 3110 3120 EPTVTWYKDG QPLVLAQRTQ ALRGGQRLEI QEAQVSDKGL YSCKVSNVAG EAVRTFTLTV 3130 3140 3150 3160 3170 3180 QVPPTFENPK TETVSQVAGS PLVLTCDVSG VPAPTVTWLK DRMPVESSAV HGVVSRGGRL 3190 3200 3210 3220 3230 3240 QLSRLQPAQA GTYTCVAENT QAEARKDFVV AVLVAPRIRS SGVAREHHVL EGQEVRLDCE 3250 3260 3270 3280 3290 3300 ADGQPPPDVA WLKDGSPLGQ DMGPHLRFYL DGGSLVLKGL RASDAGAYTC VAHNPAGEDA 3310 3320 3330 3340 3350 3360 RLHTVNVLVP PTIKQGADGS GTLVSRPGEL VTMVCPVRGS PPIHVSWLKD GLPLPLSQRT 3370 3380 3390 3400 3410 3420 LLHGSGHTLR ISKVQLADAG IFTCVAASPA GVADRNFTLQ VQVPPVLEPV EFQNDVVVVR 3430 3440 3450 3460 3470 3480 GSLVELPCEA RGVPLPLVSW MKDGEPLLSQ SLEQGPSLQL EAVGAGDSGT YSCVAVSEAG 3490 3500 3510 3520 3530 3540 EARRHFQLTV MEPPHIEDSG QPTELSLTPG APMELLCDAQ GTPQPNITWH KDGQALTRLE 3550 3560 3570 3580 3590 3600 NNSRATRVLR VRDAGLYTCL AESPAGAIEK SFRVRVQAPP NIVGPRGPRF VVGLAPGQLV 3610 3620 3630 3640 3650 3660 LECSVEAEPA PKITWHRDGI VLQEDAHTQF PERGRFLQLQ ALSTADSGDY SCTARNAAGS 3670 3680 3690 3700 3710 3720 TSVAFRVEIH TVPTIRSGPP AVNVSVNQTA LLPCQADGVP APLVSWRKDR VPLDPRSPRF 3730 3740 3750 3760 3770 3780 EILPEGSLRI QPVLAQDAGH YLCLASNSAG SDRQGRDLRV LEPPAIAPSP SNLTLTAHTP 3790 3800 3810 3820 3830 3840 ALLPCEASGS PKPLVVWWKD GQKLDFRLQQ GAYRLLPSNA LLLTAPGPQD SAQFECVVSN 3850 3860 3870 3880 3890 3900 EVGEAHRLYQ VTVHVPPTIA DDQTDFTVTM MAPVVLTCHS TGIPAPTVSW SKAGAQLGAR 3910 3920 3930 3940 3950 3960 GSGYRVSPSG ALEIGQALPI HAGRYTCSAR NSAGVAHKHV FLTVQASPVV KPLPSVVRAV 3970 3980 3990 4000 4010 4020 AEEEVLLPCE ASGIPRPTIT WQKEGLNVAT GVSTQVLPGG QLRIAHASPE DAGNYLCIAK 4030 4040 4050 4060 4070 4080 NSAGSAMGKT RLVVQVPPVI ENGLPDLSTT EGSHAFLPCK ARGSPEPNIT WDKDGQPVSG 4090 4100 4110 4120 4130 4140 AEGKFTIQPS GELLVKNLEG QDAGTYTCTA ENAVGRARRR VHLTILVLPV FTTLPGDRSL 4150 4160 4170 4180 4190 4200 RLGDRLWLRC AARGSPTPRI GWTVNDRPVT EGVSEQDGGS TLQRAAVSRE DSGTYVCWAE 4210 4220 4230 4240 4250 4260 NRVGRTQAVS FVHVKEAPVL QGEAFSYLVE PVGGSIQLDC VVRGDPVPDI HWIKDGLPLR 4270 4280 4290 4300 4310 4320 GSHLRHQLQN GSLTIHRTER DDAGRYQCLA ENEMGVAKKV VILVLQSAPV FQVEPQDMTV 4330 4340 4350 4360 4370 4380 RSGDDVALRC QATGEPTPTI EWLQAGQPLR ASRRLRTLPD GSLWLENVET GDAGTYDCVA 4390 4400 4410 4420 4430 4440 HNLLGSATAR AFLVVRGEPQ GSWGSMTGVI NGRKFGVATL NTSVMQEAHS GVSSIHSSIR 4450 4460 4470 4480 4490 4500 HVPANVGPLM RVLVVTIAPI YWALARESGE ALNGHSLTGG RFRQESHVEF ATGELLTMTQ 4510 4520 4530 4540 4550 4560 VARGLDPDGL LLLDVVVNGV VPESLADADL QVQDFEEHYV QTGPGQLFVG STQRFFQGGL 4570 4580 4590 4600 4610 4620 PSFLRCNHSI QYNAARGPQP QLVQHLRASA ISSAFDPEAE ALRFQLATAL QAEENEVGCP 4630 4640 4650 4660 4670 4680 EGFELDSQGA FCVDRDECSG GPSPCSHACL NAPGRFSCTC PTGFALAWDD RNCRDVDECA 4690 4700 4710 4720 4730 4740 WDAHLCREGQ RCVNLLGSYR CLPDCGPGFR VADGAGCEDV DECLEGLDDC HYNQLCENTP 4750 4760 4770 4780 4790 4800 GGHRCSCPRG YRMQGPSLPC LDVNECLQLP KACAYQCHNL QGSYRCLCPP GQTLLRDGKA 4810 4820 4830 4840 4850 4860 CTSLERNGQN VTTVSHRGPL LPWLRPWASI PGTSYHAWVS LRPGPMALSS VGRAWCPPGF 4870 4880 4890 4900 4910 4920 IRQNGVCTDL DECRVRNLCQ HACRNTEGSY QCLCPAGYRL LPSGKNCQDI NECEEESIEC 4930 4940 4950 4960 4970 4980 GPGQMCFNTR GSYQCVDTPC PATYRQGPSP GTCFRRCSQD CGTGGPSTLQ YRLLPLPLGV 4990 5000 5010 5020 5030 5040 RAHHDVARLT AFSEVGVPAN RTELSMLEPD PRSPFALRPL RAGLGAVYTR RALTRAGLYR 5050 5060 LTVRAAAPRH QSVFVLLIAV SPYPY
	Isoform 2 [UniParc]. Checksum: E5A1ACDF3CABD317	FASTA	4,198	448,332
	10 20 30 40 50 60 MMPGAPLLRL LTAVSAAVAV AVAGAPGTVM PPTTGDATLA FVFDVTGSMW DELMQVIDGA 70 80 90 100 110 120 SRILERSLSR RSQAIANYAL VPFHDPDIGP VTLTADPTVF QRELRELYVQ GGGDCPEMSV 130 140 150 160 170 180 GAIKAAVEVA NPGSFIYVFS DARAKDYHKK EELLRLLQLK QSQVVFVLTG DCGDRTHPGY 190 200 210 220 230 240 LAYEEIAATS SGQVFHLDKQ QVTEVLKWVE SAIQASKVHL LSTDHEEEGE HTWRLPFDPS 250 260 270 280 290 300 LKEVTISLSG PGPEIEVQDP LGRILQEDEG LNVLLNIPDS AKVVAFKPEH PGLWSIKVYS 310 320 330 340 350 360 SGRHSVRITG VSNIDFRAGF STQPLLDLNH TLEWPLQGVP ISLVINSTGL KAPGRLDSVE 370 380 390 400 410 420 LAQSSGKPLL TLPTKPLSNG STHQLWGGPP FHTPKERFYL KVKGKDHEGN PLLRVSGVSY 430 440 450 460 470 480 SGVAPGAPLV SMAPRIHGYL HQPLLVSCSV HSALPFRLQL RRGEARLGEE RHFQESGNSS 490 500 510 520 530 540 WEILRASKAE EGTYECTAVS RAGTGRAKAQ IVVTDPPPQL VPAPNVTVSP GETAVLSCRV 550 560 570 580 590 600 LGEAPYNLTW VRDWRVLPAS TGRVAQLADL SLEISGIIPT DGGRYQCVAS NANGVTRASV 610 620 630 640 650 660 WLLVREAPQV SIHTSSQHFS QGVEVKVSCS ASGYPTPHIS WSRESQALQE DSRIHVDAQG 670 680 690 700 710 720 TLIIQGVAPE DAGNYSCQAT NEVGTDQETV TLYYTDPPSV SAVNAVVLVA VGEEAVLVCE 730 740 750 760 770 780 ASGVPPPRVI WYRGGLEMIL APEGSSSGKL RIPAAQERDA GTYTCRAVNE LGDASAEIQL 790 800 810 820 830 840 AVGHAPQLTE LPRDVTVELG RSALLACRAT GRPPPTVTWR RGDGQPLGLR LGAGRGSRSR 850 860 870 880 890 900 QPDSGVLFFE SVAPEDQAPY VCEARNVFGK VQAEARLIVT GHAPPQIASS APTVRVLEGQ 910 920 930 940 950 960 PVSLPCIVLA GRPLPERHWL KDGRPLPPGS RHSIRADGSL HLDRALQEHA GRYSCVATNT 970 980 990 1000 1010 1020 AGSQHRDVEL VVQVPPRIHP TATHHITNEG VPASLPCVAS GVPAPTITWT KETNALTSRG 1030 1040 1050 1060 1070 1080 PHYNVSKEGT LLIAQPSAQD AGAYVCTATN TVGFSSQEMR LSVNRLALSK YVWEEYGLLP 1090 1100 1110 1120 1130 1140 SGSLRLAQVQ VGDSGHYECT ASNPAGSASH RYVLGVQVPP QVQPGPRVLK VLVGEALDLN 1150 1160 1170 1180 1190 1200 CVAEGNPEPQ LSWSKDGVVL QGRGPQGSVH FAAIRTSDAG RYRCEASNSA GVDAWEVELR 1210 1220 1230 1240 1250 1260 VLEPPHWGAD ETSGLLERVA GENASLPCPA RGTPKPQVTW RKGPSSEPLH GQPGVAVLEE 1270 1280 1290 1300 1310 1320 GSLFLASVSP ADSGDYECQA TNEVGSTSRR AKLVVYVPPS IREDGRKANV SGMAGQSLTL 1330 1340 1350 1360 1370 1380 ECDANGFPVP EIVWLKDAQL VGVPLGWAGY GWDLGWGQVG GHRLLDEGQS LHFPRIQEGD 1390 1400 1410 1420 1430 1440 SGLYSCRAEN QAGTAQRDFH LLVLTPPSVL GAGAAQEVLG LAGADVELQC WTSGVPTPQV 1450 1460 1470 1480 1490 1500 EWTKDRQPVL PGGPHLQVQE DGQVLRITGS HVGDEGRYQC VAFSPAGQQA RDFQLRVHAP 1510 1520 1530 1540 1550 1560 PTIWGSNETG EVAVMEDHLV QLLCEARGVP TPNITWFKDG ALLPTSTKVV YTRGGRQLQL 1570 1580 1590 1600 1610 1620 GRAQSSDAGV YTCKASNAVG AAEKATRLDV YVPPTIEGAG GRPYVVKAVA GRPVALECVA 1630 1640 1650 1660 1670 1680 RGHPSPTLSW HHEGLPVAES NESRLETDGS VLRLESPGEA SSGLYSCVAS SPAGEAVLQY 1690 1700 1710 1720 1730 1740 SVEVQVPPQL LVAEGLGQVT TIVGQPLELP CQASGSPVPT IQWLQNGRPA EELAGVQVAS 1750 1760 1770 1780 1790 1800 QGTTLHIDHV ELDHSGLFAC QATNEAGTAG AEVEVSVHGE WAPGVLEVPI GQYHWGXEHH 1810 1820 1830 1840 1850 1860 SSFPAACDPP VHRGWGAHPK PPLVEGWCSP GSLWGEPTGI PVAYSLPPPL QIEKVDLRDE 1870 1880 1890 1900 1910 1920 GIYTCAATNL AGESKREVAL KVLVPPNIEP GPVNKAVLEN ASVTLECLAS GVPPPDVSWF 1930 1940 1950 1960 1970 1980 KGHQPVSSWM GVTVSVDGRV LRIEQAQLSD AGSYRCVASN VAGSTELRYG LRVNVPPRIT 1990 2000 2010 2020 2030 2040 LPPSLPGPVL VNTPVRLTCN ATGAPSPTLM WLKDGNPVSP AGTPGLQVFP GGRVLTLASA 2050 2060 2070 2080 2090 2100 RASDSGRYSC VAVSAVGEDR QDVVLQVHMP PSILGEELNV SVVANESVAL ECQSHAMPPP 2110 2120 2130 2140 2150 2160 VLSWWKDGRP LEPRPGVHLS ADKALLQVDR ADVWDAGHYT CEALNQAGHS EKHYNLNVWV 2170 2180 2190 2200 2210 2220 APVFPLRESH TLTVREGHPT SLSCECRGVP FPKISWRKDG QPLPGEGAGL QHVSAVGRLL 2230 2240 2250 2260 2270 2280 YLGQAQLAQE GTYTCECSNV VGNSSQDLQL EVHVPPQIAG PREPPTQVSV VQDGVATLEC 2290 2300 2310 2320 2330 2340 NATGKPPPTV TWERDGQPVG AELGLQLQNQ GQSLHVERAQ AAHTGRYSCV AENLAGRAER 2350 2360 2370 2380 2390 2400 KFELSVLVPP ELIGDLDPLT NITAALHSPL TLLCEAMGIP PPAIRWFRGE EPVSPGEDTY 2410 2420 2430 2440 2450 2460 LLAGGWMLKM TQTQEQDSGL YSCLASNEAG EARRNFSVEV LVPPSIENED LEEVIKVLDG 2470 2480 2490 2500 2510 2520 QTAHLMCNVT GHPQPKLTWF KDGRPLARGD AHHISPDGVL LQVLQANLSS AGHYSCIAAN 2530 2540 2550 2560 2570 2580 AVGEKTKHFQ LSVLLAPTIL GGAEDSADEE VTVTVNNPIS LICEALAFPS PNITWMKDGA 2590 2600 2610 2620 2630 2640 PFEASRNIQL LPGTHGLQIL NAQKEDAGQY TCVVTNELGE AVKNYHVEVL IPPSISKDDP 2650 2660 2670 2680 2690 2700 LGEVGVKEVK TKVNSTLTLE CESWAVPPPT IRWYKDGQPV TPSSRLQVLG EGRLLQIQPT 2710 2720 2730 2740 2750 2760 QVSDSGRYLC VATNVAGEDD QDFNVLIQVP PMFQKVGDFS AAFEILSREE EARGGVTEYR 2770 2780 2790 2800 2810 2820 EIVENNPAYL YCDTNAIPPP DLTWYREDQP LSAGDEVSVL QGGRVLQIPL VRAENAGRYS 2830 2840 2850 2860 2870 2880 CKASNEVGED WLHYELLVLT PPVILGDTEE LVEEVTVNAS STVSLQCPAL GNPVPTISWL 2890 2900 2910 2920 2930 2940 QNGLPFSPSP RLQVLEDGQV LQVSTAEVAD AASYMCVAEN QAGSAEKLFT LRVQVPPRIA 2950 2960 2970 2980 2990 3000 GLDLEQVTAI LNSSVSLPCD VHAHPNPEVT WYKDSQALSL GEEVFLLPGT HTLQLGRARL 3010 3020 3030 3040 3050 3060 SDSGMYTCEA LNAAGRDQKL VQLSVLVPPA FRQAPRGPQD AVLVRVGDKA VLSCETDALP 3070 3080 3090 3100 3110 3120 EPTVTWYKDG QPLVLAQRTQ ALRGGQRLEI QEAQVSDKGL YSCKVSNVAG EAVRTFTLTV 3130 3140 3150 3160 3170 3180 QVPPTFENPK TETVSQVAGS PLVLTCDVSG VPAPTVTWLK DRMPVESSAV HGVVSRGGRL 3190 3200 3210 3220 3230 3240 QLSRLQPAQA GTYTCVAENT QAEARKDFVV AVLVAPRIRS SGVAREHHVL EGQEVRLDCE 3250 3260 3270 3280 3290 3300 ADGQPPPDVA WLKDGSPLGQ DMGPHLRFYL DGGSLVLKGL RASDAGAYTC VAHNPAGEDA 3310 3320 3330 3340 3350 3360 RLHTVNVLVP PTIKQGADGS GTLVSRPGEL VTMVCPVRGS PPIHVSWLKD GLPLPLSQRT 3370 3380 3390 3400 3410 3420 LLHGSGHTLR ISKVQLADAG IFTCVAASPA GVADRNFTLQ VQVPPVLEPV EFQNDVVVVR 3430 3440 3450 3460 3470 3480 GSLVELPCEA RGVPLPLVSW MKDGEPLLSQ SLEQGPSLQL EAVGAGDSGT YSCVAVSEAG 3490 3500 3510 3520 3530 3540 EARRHFQLTV MEPPHIEDSG QPTELSLTPG APMELLCDAQ GTPQPNITWH KDGQALTRLE 3550 3560 3570 3580 3590 3600 NNSRATRVLR VRDAGLYTCL AESPAGAIEK SFRVRVQAPP NIVGPRGPRF VVGLAPGQLV 3610 3620 3630 3640 3650 3660 LECSVEAEPA PKITWHRDGI VLQEDAHTQF PERGRFLQLQ ALSTADSGDY SCTARNAAGS 3670 3680 3690 3700 3710 3720 TSVAFRVEIH TVPTIRSGPP AVNVSVNQTA LLPCQADGVP APLVSWRKDR VPLDPRSPRF 3730 3740 3750 3760 3770 3780 EILPEGSLRI QPVLAQDAGH YLCLASNSAG SDRQGRDLRV LEPPAIAPSP SNLTLTAHTP 3790 3800 3810 3820 3830 3840 ALLPCEASGS PKPLVVWWKD GQKLDFRLQQ GAYRLLPSNA LLLTAPGPQD SAQFECVVSN 3850 3860 3870 3880 3890 3900 EVGEAHRLYQ VTVHVPPTIA DDQTDFTVTM MAPVVLTCHS TGIPAPTVSW SKAGAQLGAR 3910 3920 3930 3940 3950 3960 GSGYRVSPSG ALEIGQALPI HAGRYTCSAR NSAGVAHKHV FLTVQASPVV KPLPSVVRAV 3970 3980 3990 4000 4010 4020 AEEEVLLPCE ASGIPRPTIT WQKEGLNVAT GVSTQVLPGG QLRIAHASPE DAGNYLCIAK 4030 4040 4050 4060 4070 4080 NSAGSAMGKT RLVVQVPPVI ENGLPDLSTT EGSHAFLPCK ARGSPEPNIT WDKDGQPVSG 4090 4100 4110 4120 4130 4140 AEGKFTIQPS GELLVKNLEG QDAGTYTCTA ENAVGRARRR VHLTILVLPV FTTLPGDRSL 4150 4160 4170 4180 4190 RLGDRLWLRC AARGSPTPRI GWTVNDRPVT GLGLLGMGGT ESQDTGRLRR EGRWGDPT
	Isoform 3 [UniParc]. Checksum: 378B87433B805BF9	FASTA	4,427	474,146
	10 20 30 40 50 60 MMPGAPLLRL LTAVSAAVAV AVAGAPGTVM PPTTGDATLA FVFDVTGSMW DELMQVIDGA 70 80 90 100 110 120 SRILERSLSR RSQAIANYAL VPFHDPDIGP VTLTADPTVF QRELRELYVQ GGGDCPEMSV 130 140 150 160 170 180 GAIKAAVEVA NPGSFIYVFS DARAKDYHKK EELLRLLQLK QSQVVFVLTG DCGDRTHPGY 190 200 210 220 230 240 LAYEEIAATS SGQVFHLDKQ QVTEVLKWVE SAIQASKVHL LSTDHEEEGE HTWRLPFDPS 250 260 270 280 290 300 LKEVTISLSG PGPEIEVQDP LGRILQEDEG LNVLLNIPDS AKVVAFKPEH PGLWSIKVYS 310 320 330 340 350 360 SGRHSVRITG VSNIDFRAGF STQPLLDLNH TLEWPLQGVP ISLVINSTGL KAPGRLDSVE 370 380 390 400 410 420 LAQSSGKPLL TLPTKPLSNG STHQLWGGPP FHTPKERFYL KVKGKDHEGN PLLRVSGVSY 430 440 450 460 470 480 SGVAPGAPLV SMAPRIHGYL HQPLLVSCSV HSALPFRLQL RRGEARLGEE RHFQESGNSS 490 500 510 520 530 540 WEILRASKAE EGTYECTAVS RAGTGRAKAQ IVVTDPPPQL VPAPNVTVSP GETAVLSCRV 550 560 570 580 590 600 LGEAPYNLTW VRDWRVLPAS TGRVAQLADL SLEISGIIPT DGGRYQCVAS NANGVTRASV 610 620 630 640 650 660 WLLVREAPQV SIHTSSQHFS QGVEVKVSCS ASGYPTPHIS WSRESQALQE DSRIHVDAQG 670 680 690 700 710 720 TLIIQGVAPE DAGNYSCQAT NEVGTDQETV TLYYTDPPSV SAVNAVVLVA VGEEAVLVCE 730 740 750 760 770 780 ASGVPPPRVI WYRGGLEMIL APEGSSSGKL RIPAAQERDA GTYTCRAVNE LGDASAEIQL 790 800 810 820 830 840 AVGHAPQLTE LPRDVTVELG RSALLACRAT GRPPPTVTWR RGDGQPLGLR LGAGRGSRSR 850 860 870 880 890 900 QPDSGVLFFE SVAPEDQAPY VCEARNVFGK VQAEARLIVT GHAPPQIASS APTVRVLEGQ 910 920 930 940 950 960 PVSLPCIVLA GRPLPERHWL KDGRPLPPGS RHSIRADGSL HLDRALQEHA GRYSCVATNT 970 980 990 1000 1010 1020 AGSQHRDVEL VVQVPPRIHP TATHHITNEG VPASLPCVAS GVPAPTITWT KETNALTSRG 1030 1040 1050 1060 1070 1080 PHYNVSKEGT LLIAQPSAQD AGAYVCTATN TVGFSSQEMR LSVNRLALSK YVWEEYGLLP 1090 1100 1110 1120 1130 1140 SGSLRLAQVQ VGDSGHYECT ASNPAGSASH RYVLGVQVPP QVQPGPRVLK VLVGEALDLN 1150 1160 1170 1180 1190 1200 CVAEGNPEPQ LSWSKDGVVL QGRGPQGSVH FAAIRTSDAG RYRCEASNSA GVDAWEVELR 1210 1220 1230 1240 1250 1260 VLEPPHWGAD ETSGLLERVA GENASLPCPA RGTPKPQVTW RKGPSSEPLH GQPGVAVLEE 1270 1280 1290 1300 1310 1320 GSLFLASVSP ADSGDYECQA TNEVGSTSRR AKLVVYVPPS IREDGRKANV SGMAGQSLTL 1330 1340 1350 1360 1370 1380 ECDANGFPVP EIVWLKDAQL VGVPLGWAGY GWDLGWGQVG GHRLLDEGQS LHFPRIQEGD 1390 1400 1410 1420 1430 1440 SGLYSCRAEN QAGTAQRDFH LLVLTPPSVL GAGAAQEVLG LAGADVELQC WTSGVPTPQV 1450 1460 1470 1480 1490 1500 EWTKDRQPVL PGGPHLQVQE DGQVLRITGS HVGDEGRYQC VAFSPAGQQA RDFQLRVHAP 1510 1520 1530 1540 1550 1560 PTIWGSNETG EVAVMEDHLV QLLCEARGVP TPNITWFKDG ALLPTSTKVV YTRGGRQLQL 1570 1580 1590 1600 1610 1620 GRAQSSDAGV YTCKASNAVG AAEKATRLDV YVPPTIEGAG GRPYVVKAVA GRPVALECVA 1630 1640 1650 1660 1670 1680 RGHPSPTLSW HHEGLPVAES NESRLETDGS VLRLESPGEA SSGLYSCVAS SPAGEAVLQY 1690 1700 1710 1720 1730 1740 SVEVQVPPQL LVAEGLGQVT TIVGQPLELP CQASGSPVPT IQWLQNGRPA EELAGVQVAS 1750 1760 1770 1780 1790 1800 QGTTLHIDHV ELDHSGLFAC QATNEAGTAG AEVEVSVHGE WAPGVLEVPI GQYHWGXEHH 1810 1820 1830 1840 1850 1860 SSFPAACDPP VHRGWGAHPK PPLVEGWCSP GSLWGEPTGI PVAYSLPPPL QIEKVDLRDE 1870 1880 1890 1900 1910 1920 GIYTCAATNL AGESKREVAL KVLVPPNIEP GPVNKAVLEN ASVTLECLAS GVPPPDVSWF 1930 1940 1950 1960 1970 1980 KGHQPVSSWM GVTVSVDGRV LRIEQAQLSD AGSYRCVASN VAGSTELRYG LRVNVPPRIT 1990 2000 2010 2020 2030 2040 LPPSLPGPVL VNTPVRLTCN ATGAPSPTLM WLKDGNPVSP AGTPGLQVFP GGRVLTLASA 2050 2060 2070 2080 2090 2100 RASDSGRYSC VAVSAVGEDR QDVVLQVHMP PSILGEELNV SVVANESVAL ECQSHAMPPP 2110 2120 2130 2140 2150 2160 VLSWWKDGRP LEPRPGVHLS ADKALLQVDR ADVWDAGHYT CEALNQAGHS EKHYNLNVWV 2170 2180 2190 2200 2210 2220 APVFPLRESH TLTVREGHPT SLSCECRGVP FPKISWRKDG QPLPGEGAGL QHVSAVGRLL 2230 2240 2250 2260 2270 2280 YLGQAQLAQE GTYTCECSNV VGNSSQDLQL EVHVPPQIAG PREPPTQVSV VQDGVATLEC 2290 2300 2310 2320 2330 2340 NATGKPPPTV TWERDGQPVG AELGLQLQNQ GQSLHVERAQ AAHTGRYSCV AENLAGRAER 2350 2360 2370 2380 2390 2400 KFELSVLVPP ELIGDLDPLT NITAALHSPL TLLCEAMGIP PPAIRWFRGE EPVSPGEDTY 2410 2420 2430 2440 2450 2460 LLAGGWMLKM TQTQEQDSGL YSCLASNEAG EARRNFSVEV LVPPSIENED LEEVIKVLDG 2470 2480 2490 2500 2510 2520 QTAHLMCNVT GHPQPKLTWF KDGRPLARGD AHHISPDGVL LQVLQANLSS AGHYSCIAAN 2530 2540 2550 2560 2570 2580 AVGEKTKHFQ LSVLLAPTIL GGAEDSADEE VTVTVNNPIS LICEALAFPS PNITWMKDGA 2590 2600 2610 2620 2630 2640 PFEASRNIQL LPGTHGLQIL NAQKEDAGQY TCVVTNELGE AVKNYHVEVL IPPSISKDDP 2650 2660 2670 2680 2690 2700 LGEVGVKEVK TKVNSTLTLE CESWAVPPPT IRWYKDGQPV TPSSRLQVLG EGRLLQIQPT 2710 2720 2730 2740 2750 2760 QVSDSGRYLC VATNVAGEDD QDFNVLIQVP PMFQKVGDFS AAFEILSREE EARGGVTEYR 2770 2780 2790 2800 2810 2820 EIVENNPAYL YCDTNAIPPP DLTWYREDQP LSAGDEVSVL QGGRVLQIPL VRAENAGRYS 2830 2840 2850 2860 2870 2880 CKASNEVGED WLHYELLVLT PPVILGDTEE LVEEVTVNAS STVSLQCPAL GNPVPTISWL 2890 2900 2910 2920 2930 2940 QNGLPFSPSP RLQVLEDGQV LQVSTAEVAD AASYMCVAEN QAGSAEKLFT LRVQVPPRIA 2950 2960 2970 2980 2990 3000 GLDLEQVTAI LNSSVSLPCD VHAHPNPEVT WYKDSQALSL GEEVFLLPGT HTLQLGRARL 3010 3020 3030 3040 3050 3060 SDSGMYTCEA LNAAGRDQKL VQLSVLVPPA FRQAPRGPQD AVLVRVGDKA VLSCETDALP 3070 3080 3090 3100 3110 3120 EPTVTWYKDG QPLVLAQRTQ ALRGGQRLEI QEAQVSDKGL YSCKVSNVAG EAVRTFTLTV 3130 3140 3150 3160 3170 3180 QVPPTFENPK TETVSQVAGS PLVLTCDVSG VPAPTVTWLK DRMPVESSAV HGVVSRGGRL 3190 3200 3210 3220 3230 3240 QLSRLQPAQA GTYTCVAENT QAEARKDFVV AVLVAPRIRS SGVAREHHVL EGQEVRLDCE 3250 3260 3270 3280 3290 3300 ADGQPPPDVA WLKDGSPLGQ DMGPHLRFYL DGGSLVLKGL RASDAGAYTC VAHNPAGEDA 3310 3320 3330 3340 3350 3360 RLHTVNVLVP PTIKQGADGS GTLVSRPGEL VTMVCPVRGS PPIHVSWLKD GLPLPLSQRT 3370 3380 3390 3400 3410 3420 LLHGSGHTLR ISKVQLADAG IFTCVAASPA GVADRNFTLQ CPLSWSRWSS RMTWWWFVAP 3430 3440 3450 3460 3470 3480 WWNSRARPGA FPCLSCRGMK DGEPLLSQSL EQGPSLQLEA VGAGDSGTYS CVAVSEAGEA 3490 3500 3510 3520 3530 3540 RRHFQLTVME PPHIEDSGQP TELSLTPGAP MELLCDAQGT PQPNITWHKD GQALTRLENN 3550 3560 3570 3580 3590 3600 SRATRVLRVE NVQVRDAGLY TCLAESPAGA IEKSFRVRVQ APPNIVGPRG PRFVVGLAPG 3610 3620 3630 3640 3650 3660 QLVLECSVEA EPAPKITWHR DGIVLQEDAH TQFPERGRFL QLQALSTADS GDYSCTARNA 3670 3680 3690 3700 3710 3720 AGSTSVAFRV EIHTVPTIRS GPPAVNVSVN QTALLPCQAD GVPAPLVSWR KDRVPLDPRS 3730 3740 3750 3760 3770 3780 PRFEILPEGS LRIQPVLAQD AGHYLCLASN SAGSDRQGRD LRVLALLPCE ASGSPKPLVV 3790 3800 3810 3820 3830 3840 WWKDGQKLDF RLQQGAYRLL PSNALLLTAP GPQDSAQFEC VVSNEVGEAH RLYQVTVHVP 3850 3860 3870 3880 3890 3900 PTIADDQTDF TVTMMAPVVL TCHSTGIPAP TVSWSKAGAQ LGARGSGYRV SPSGALEIGQ 3910 3920 3930 3940 3950 3960 ALPIHAGRYT CSARNSAGVA HKHVFLTVQA SPVVKPLPSV VRAVAEEEVL LPCEASGIPR 3970 3980 3990 4000 4010 4020 PTITWQKEGL NVATGVSTQV LPGGQLRIAH ASPEDAGNYL CIAKNSAGSA MGKTRLVVQV 4030 4040 4050 4060 4070 4080 PPVIENGLPD LSTTEGSHAF LPCKARGSPE PNITWDKDGQ PVSGAEGKFT IQPSGELLVK 4090 4100 4110 4120 4130 4140 NLEGQDAGTY TCTAENAVGR ARRRVHLTIL VLPVFTTLPG DRSLRLGDRL WLRCAARGSP 4150 4160 4170 4180 4190 4200 TPRIGWTVND RPVTEGVSEQ DGGSTLQRAA VSREDSGTYV CWAENRVGRT QAVSFVHVKE 4210 4220 4230 4240 4250 4260 APVLQGEAFS YLVEPVGGSI QLDCVVRGDP VPDIHWIKDG LPLRGSHLRH QLQNGSLTIH 4270 4280 4290 4300 4310 4320 RTERDDAGRY QCLAENEMGV AKKVVILVLQ SAPVFQVEPQ DMTVRSGDDV ALRCQATGEP 4330 4340 4350 4360 4370 4380 TPTIEWLQAG QPLRASRRLR TLPDGSLWLE NVETGDAGTY DCVAHNLLGS ATARAFLVVR 4390 4400 4410 4420 GMGHPCLDLR GQRQDLLPMG IVWCLWETCP LPCQLPTSSL CFITSPE

References

[1]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3793-4508 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4762-5065 (ISOFORM 1). Tissue: Small intestine and Thymus.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3088-5065 (ISOFORM 3). Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL354898 Genomic DNA. No translation available. AL360004 Genomic DNA. No translation available. CH471090 Genomic DNA. Translation: EAW87931.1. Sequence problems. AK074396 mRNA. Translation: BAB85069.1. Different initiation. AK093583 mRNA. Translation: BAC04201.1. Different initiation. AL834139 mRNA. Translation: CAD38854.1.
IPI	IPI00335009. IPI00936570. IPI00964287.
UniGene	Hs.32194. Hs.512559.
3D structure databases
HSSP	HSSP built from PDB template 1EV2 based on UniProtKB Q9UQH9.
ProteinModelPortal	Q8NDA2.
SMR	Q8NDA2. Positions 427-1582, 1652-1777, 2313-2339, 2943-4397, 4622-4802, 4871-4949.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000277491.
PTM databases
PhosphoSite	Q8NDA2.
Polymorphism databases
DMDM	298351848.
Proteomic databases
PaxDb	Q8NDA2.
PRIDE	Q8NDA2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302481; ENSP00000305590; ENSG00000148357. ENST00000597795; ENSP00000472503; ENSG00000269324.
Organism-specific databases
GeneCards	GC09P133029. GC09P133274.
H-InvDB	HIX0008467.
HGNC	HGNC:21293. HMCN2.
HPA	HPA053903.
neXtProt	NX_Q8NDA2.
PharmGKB	PA142671680.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000172035.
HOVERGEN	HBG073398.
Gene expression databases
ArrayExpress	Q8NDA2.
Bgee	Q8NDA2.
Family and domain databases
Gene3D	2.40.155.10. 1 hit. 2.60.40.10. 42 hits.
InterPro	IPR026823. cEGF. IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR006605. G2_nidogen/fibulin_G2F. IPR009017. GFP. IPR023413. GFP_like. IPR009030. Growth_fac_rcpt. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR002035. VWF_A. [Graphical view]
Pfam	PF12662. cEGF. 1 hit. PF07645. EGF_CA. 4 hits. PF07474. G2F. 1 hit. PF07679. I-set. 39 hits. [Graphical view]
SMART	SM00179. EGF_CA. 6 hits. SM00409. IG. 2 hits. SM00408. IGc2. 40 hits. SM00327. VWA. 1 hit. [Graphical view]
SUPFAM	SSF54511. GFP_like. 1 hit. SSF57184. Grow_fac_recept. 1 hit.
PROSITE	PS00010. ASX_HYDROXYL. 3 hits. PS00022. EGF_1. False negative. PS01186. EGF_2. 3 hits. PS50026. EGF_3. 5 hits. PS01187. EGF_CA. 5 hits. PS50835. IG_LIKE. 40 hits. PS50993. NIDOGEN_G2. 1 hit. PS50234. VWFA. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HMCN2_HUMAN

Accession

Primary (citable) accession number: Q8NDA2
Secondary accession number(s): Q8N225, Q8TCI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 15, 2010
Last sequence update:	June 15, 2010
Last modified:	May 1, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.