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Q8NDA2

- HMCN2_HUMAN

UniProt

Q8NDA2 - HMCN2_HUMAN

Protein

Hemicentin-2

Gene

HMCN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. response to stimulus Source: UniProtKB-KW

    Keywords - Biological processi

    Sensory transduction

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemicentin-2
    Gene namesi
    Name:HMCN2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:21293. HMCN2.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671680.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 50655042Hemicentin-2PRO_0000395108Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi346 – 3461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi525 – 5251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi538 ↔ 587By similarity
    Glycosylationi547 – 5471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi629 ↔ 677By similarity
    Glycosylationi674 – 6741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi719 ↔ 765By similarity
    Disulfide bondi807 ↔ 862By similarity
    Disulfide bondi906 ↔ 955By similarity
    Disulfide bondi997 ↔ 1046By similarity
    Glycosylationi1024 – 10241N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1141 ↔ 1184By similarity
    Glycosylationi1223 – 12231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1228 ↔ 1278By similarity
    Glycosylationi1309 – 13091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1322 ↔ 1386By similarity
    Disulfide bondi1430 ↔ 1480By similarity
    Glycosylationi1507 – 15071N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1524 ↔ 1573By similarity
    Glycosylationi1533 – 15331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1618 ↔ 1667By similarity
    Glycosylationi1641 – 16411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1711 ↔ 1760By similarity
    Disulfide bondi1807 ↔ 1865By similarity
    Glycosylationi1900 – 19001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1907 ↔ 1956By similarity
    Disulfide bondi1999 ↔ 2050By similarity
    Glycosylationi2000 – 20001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2079 – 20791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2085 – 20851N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2092 ↔ 2141By similarity
    Disulfide bondi2184 ↔ 2235By similarity
    Glycosylationi2243 – 22431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2280 ↔ 2329By similarity
    Glycosylationi2281 – 22811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2361 – 23611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2374 ↔ 2423By similarity
    Glycosylationi2435 – 24351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2467 ↔ 2516By similarity
    Glycosylationi2468 – 24681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2507 – 25071N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2563 ↔ 2612By similarity
    Glycosylationi2572 – 25721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2654 – 26541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2661 ↔ 2710By similarity
    Disulfide bondi2772 ↔ 2821By similarity
    Glycosylationi2858 – 28581N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2867 ↔ 2916By similarity
    Glycosylationi2952 – 29521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2959 ↔ 3008By similarity
    Disulfide bondi3054 ↔ 3103By similarity
    Disulfide bondi3146 ↔ 3195By similarity
    Disulfide bondi3239 ↔ 3290By similarity
    Disulfide bondi3335 ↔ 3384By similarity
    Glycosylationi3396 – 33961N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3428 ↔ 3473By similarity
    Disulfide bondi3517 ↔ 3559By similarity
    Glycosylationi3526 – 35261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3541 – 35411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3603 ↔ 3652By similarity
    Glycosylationi3683 – 36831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3687 – 36871N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3694 ↔ 3743By similarity
    Glycosylationi3772 – 37721N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3785 ↔ 3836By similarity
    Disulfide bondi3878 ↔ 3927By similarity
    Disulfide bondi3969 ↔ 4017By similarity
    Disulfide bondi4059 ↔ 4108By similarity
    Glycosylationi4068 – 40681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4150 ↔ 4197By similarity
    Disulfide bondi4240 ↔ 4288By similarity
    Glycosylationi4270 – 42701N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4330 ↔ 4378By similarity
    Glycosylationi4421 – 44211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4567 – 45671N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4638 ↔ 4649By similarity
    Disulfide bondi4645 ↔ 4658By similarity
    Disulfide bondi4660 ↔ 4673By similarity
    Disulfide bondi4679 ↔ 4692By similarity
    Disulfide bondi4686 ↔ 4701By similarity
    Disulfide bondi4705 ↔ 4717By similarity
    Disulfide bondi4723 ↔ 4736By similarity
    Disulfide bondi4730 ↔ 4745By similarity
    Disulfide bondi4766 ↔ 4777By similarity
    Disulfide bondi4773 ↔ 4786By similarity
    Disulfide bondi4788 ↔ 4801By similarity
    Glycosylationi4810 – 48101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4873 ↔ 4883By similarity
    Disulfide bondi4879 ↔ 4892By similarity
    Disulfide bondi4894 ↔ 4907By similarity
    Glycosylationi5000 – 50001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NDA2.
    PRIDEiQ8NDA2.

    PTM databases

    PhosphoSiteiQ8NDA2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NDA2.
    BgeeiQ8NDA2.

    Organism-specific databases

    HPAiHPA053903.
    HPA060387.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000277491.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NDA2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 210175VWFAAdd
    BLAST
    Domaini518 – 60386Ig-like C2-type 1Add
    BLAST
    Domaini608 – 69184Ig-like C2-type 2Add
    BLAST
    Domaini698 – 78184Ig-like C2-type 3Add
    BLAST
    Domaini786 – 88095Ig-like C2-type 4Add
    BLAST
    Domaini885 – 97187Ig-like C2-type 5Add
    BLAST
    Domaini976 – 106287Ig-like C2-type 6Add
    BLAST
    Domaini1039 – 111577Ig-like C2-type 7Add
    BLAST
    Domaini1120 – 120081Ig-like C2-type 8Add
    BLAST
    Domaini1207 – 129488Ig-like C2-type 9Add
    BLAST
    Domaini1299 – 1400102Ig-like C2-type 10Add
    BLAST
    Domaini1407 – 149690Ig-like C2-type 11Add
    BLAST
    Domaini1501 – 158989Ig-like C2-type 12Add
    BLAST
    Domaini1594 – 168592Ig-like C2-type 13Add
    BLAST
    Domaini1688 – 177689Ig-like C2-type 14Add
    BLAST
    Domaini1783 – 187997Ig-like C2-type 15Add
    BLAST
    Domaini1886 – 197489Ig-like C2-type 16Add
    BLAST
    Domaini1977 – 206690Ig-like C2-type 17Add
    BLAST
    Domaini2071 – 215787Ig-like C2-type 18Add
    BLAST
    Domaini2162 – 225392Ig-like C2-type 19Add
    BLAST
    Domaini2256 – 234590Ig-like C2-type 20Add
    BLAST
    Domaini2350 – 243990Ig-like C2-type 21Add
    BLAST
    Domaini2444 – 253289Ig-like C2-type 22Add
    BLAST
    Domaini2537 – 262892Ig-like C2-type 23Add
    BLAST
    Domaini2633 – 272492Ig-like C2-type 24Add
    BLAST
    Domaini2731 – 2837107Ig-like C2-type 25Add
    BLAST
    Domaini2841 – 293090Ig-like C2-type 26Add
    BLAST
    Domaini2937 – 302488Ig-like C2-type 27Add
    BLAST
    Domaini3029 – 311991Ig-like C2-type 28Add
    BLAST
    Domaini3123 – 321189Ig-like C2-type 29Add
    BLAST
    Domaini3216 – 330691Ig-like C2-type 30Add
    BLAST
    Domaini3311 – 339888Ig-like C2-type 31Add
    BLAST
    Domaini3404 – 348986Ig-like C2-type 32Add
    BLAST
    Domaini3494 – 357582Ig-like C2-type 33Add
    BLAST
    Domaini3580 – 366889Ig-like C2-type 34Add
    BLAST
    Domaini3673 – 375987Ig-like C2-type 35Add
    BLAST
    Domaini3764 – 385491Ig-like C2-type 36Add
    BLAST
    Domaini3857 – 394387Ig-like C2-type 37Add
    BLAST
    Domaini3948 – 403386Ig-like C2-type 38Add
    BLAST
    Domaini4037 – 412488Ig-like C2-type 39Add
    BLAST
    Domaini4129 – 421082Ig-like C2-type 40Add
    BLAST
    Domaini4218 – 430184Ig-like C2-type 41Add
    BLAST
    Domaini4309 – 439486Ig-like C2-type 42Add
    BLAST
    Domaini4398 – 4620223Nidogen G2 beta-barrelPROSITE-ProRule annotationAdd
    BLAST
    Domaini4634 – 467441EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini4675 – 471844EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini4719 – 475739EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini4762 – 480241EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini4869 – 490840EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 5 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 nidogen G2 beta-barrel domain.PROSITE-ProRule annotation
    Contains 1 VWFA domain.Curated

    Keywords - Domaini

    EGF-like domain, Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000172035.
    HOVERGENiHBG073398.
    OrthoDBiEOG78D7KD.
    PhylomeDBiQ8NDA2.

    Family and domain databases

    Gene3Di2.40.155.10. 1 hit.
    2.60.40.10. 42 hits.
    InterProiIPR026823. cEGF.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR006605. G2_nidogen/fibulin_G2F.
    IPR009017. GFP.
    IPR023413. GFP_like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF12662. cEGF. 1 hit.
    PF07645. EGF_CA. 4 hits.
    PF07474. G2F. 1 hit.
    PF07679. I-set. 39 hits.
    [Graphical view]
    SMARTiSM00179. EGF_CA. 6 hits.
    SM00409. IG. 2 hits.
    SM00408. IGc2. 40 hits.
    SM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    SSF54511. SSF54511. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 5 hits.
    PS01187. EGF_CA. 5 hits.
    PS50835. IG_LIKE. 40 hits.
    PS50993. NIDOGEN_G2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NDA2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MMPGAPLLRL LTAVSAAVAV AVAGAPGTVM PPTTGDATLA FVFDVTGSMW     50
    DELMQVIDGA SRILERSLSR RSQAIANYAL VPFHDPDIGP VTLTADPTVF 100
    QRELRELYVQ GGGDCPEMSV GAIKAAVEVA NPGSFIYVFS DARAKDYHKK 150
    EELLRLLQLK QSQVVFVLTG DCGDRTHPGY LAYEEIAATS SGQVFHLDKQ 200
    QVTEVLKWVE SAIQASKVHL LSTDHEEEGE HTWRLPFDPS LKEVTISLSG 250
    PGPEIEVQDP LGRILQEDEG LNVLLNIPDS AKVVAFKPEH PGLWSIKVYS 300
    SGRHSVRITG VSNIDFRAGF STQPLLDLNH TLEWPLQGVP ISLVINSTGL 350
    KAPGRLDSVE LAQSSGKPLL TLPTKPLSNG STHQLWGGPP FHTPKERFYL 400
    KVKGKDHEGN PLLRVSGVSY SGVAPGAPLV SMAPRIHGYL HQPLLVSCSV 450
    HSALPFRLQL RRGEARLGEE RHFQESGNSS WEILRASKAE EGTYECTAVS 500
    RAGTGRAKAQ IVVTDPPPQL VPAPNVTVSP GETAVLSCRV LGEAPYNLTW 550
    VRDWRVLPAS TGRVAQLADL SLEISGIIPT DGGRYQCVAS NANGVTRASV 600
    WLLVREAPQV SIHTSSQHFS QGVEVKVSCS ASGYPTPHIS WSRESQALQE 650
    DSRIHVDAQG TLIIQGVAPE DAGNYSCQAT NEVGTDQETV TLYYTDPPSV 700
    SAVNAVVLVA VGEEAVLVCE ASGVPPPRVI WYRGGLEMIL APEGSSSGKL 750
    RIPAAQERDA GTYTCRAVNE LGDASAEIQL AVGHAPQLTE LPRDVTVELG 800
    RSALLACRAT GRPPPTVTWR RGDGQPLGLR LGAGRGSRSR QPDSGVLFFE 850
    SVAPEDQAPY VCEARNVFGK VQAEARLIVT GHAPPQIASS APTVRVLEGQ 900
    PVSLPCIVLA GRPLPERHWL KDGRPLPPGS RHSIRADGSL HLDRALQEHA 950
    GRYSCVATNT AGSQHRDVEL VVQVPPRIHP TATHHITNEG VPASLPCVAS 1000
    GVPAPTITWT KETNALTSRG PHYNVSKEGT LLIAQPSAQD AGAYVCTATN 1050
    TVGFSSQEMR LSVNRLALSK YVWEEYGLLP SGSLRLAQVQ VGDSGHYECT 1100
    ASNPAGSASH RYVLGVQVPP QVQPGPRVLK VLVGEALDLN CVAEGNPEPQ 1150
    LSWSKDGVVL QGRGPQGSVH FAAIRTSDAG RYRCEASNSA GVDAWEVELR 1200
    VLEPPHWGAD ETSGLLERVA GENASLPCPA RGTPKPQVTW RKGPSSEPLH 1250
    GQPGVAVLEE GSLFLASVSP ADSGDYECQA TNEVGSTSRR AKLVVYVPPS 1300
    IREDGRKANV SGMAGQSLTL ECDANGFPVP EIVWLKDAQL VGVPLGWAGY 1350
    GWDLGWGQVG GHRLLDEGQS LHFPRIQEGD SGLYSCRAEN QAGTAQRDFH 1400
    LLVLTPPSVL GAGAAQEVLG LAGADVELQC WTSGVPTPQV EWTKDRQPVL 1450
    PGGPHLQVQE DGQVLRITGS HVGDEGRYQC VAFSPAGQQA RDFQLRVHAP 1500
    PTIWGSNETG EVAVMEDHLV QLLCEARGVP TPNITWFKDG ALLPTSTKVV 1550
    YTRGGRQLQL GRAQSSDAGV YTCKASNAVG AAEKATRLDV YVPPTIEGAG 1600
    GRPYVVKAVA GRPVALECVA RGHPSPTLSW HHEGLPVAES NESRLETDGS 1650
    VLRLESPGEA SSGLYSCVAS SPAGEAVLQY SVEVQVPPQL LVAEGLGQVT 1700
    TIVGQPLELP CQASGSPVPT IQWLQNGRPA EELAGVQVAS QGTTLHIDHV 1750
    ELDHSGLFAC QATNEAGTAG AEVEVSVHGE WAPGVLEVPI GQYHWGXEHH 1800
    SSFPAACDPP VHRGWGAHPK PPLVEGWCSP GSLWGEPTGI PVAYSLPPPL 1850
    QIEKVDLRDE GIYTCAATNL AGESKREVAL KVLVPPNIEP GPVNKAVLEN 1900
    ASVTLECLAS GVPPPDVSWF KGHQPVSSWM GVTVSVDGRV LRIEQAQLSD 1950
    AGSYRCVASN VAGSTELRYG LRVNVPPRIT LPPSLPGPVL VNTPVRLTCN 2000
    ATGAPSPTLM WLKDGNPVSP AGTPGLQVFP GGRVLTLASA RASDSGRYSC 2050
    VAVSAVGEDR QDVVLQVHMP PSILGEELNV SVVANESVAL ECQSHAMPPP 2100
    VLSWWKDGRP LEPRPGVHLS ADKALLQVDR ADVWDAGHYT CEALNQAGHS 2150
    EKHYNLNVWV APVFPLRESH TLTVREGHPT SLSCECRGVP FPKISWRKDG 2200
    QPLPGEGAGL QHVSAVGRLL YLGQAQLAQE GTYTCECSNV VGNSSQDLQL 2250
    EVHVPPQIAG PREPPTQVSV VQDGVATLEC NATGKPPPTV TWERDGQPVG 2300
    AELGLQLQNQ GQSLHVERAQ AAHTGRYSCV AENLAGRAER KFELSVLVPP 2350
    ELIGDLDPLT NITAALHSPL TLLCEAMGIP PPAIRWFRGE EPVSPGEDTY 2400
    LLAGGWMLKM TQTQEQDSGL YSCLASNEAG EARRNFSVEV LVPPSIENED 2450
    LEEVIKVLDG QTAHLMCNVT GHPQPKLTWF KDGRPLARGD AHHISPDGVL 2500
    LQVLQANLSS AGHYSCIAAN AVGEKTKHFQ LSVLLAPTIL GGAEDSADEE 2550
    VTVTVNNPIS LICEALAFPS PNITWMKDGA PFEASRNIQL LPGTHGLQIL 2600
    NAQKEDAGQY TCVVTNELGE AVKNYHVEVL IPPSISKDDP LGEVGVKEVK 2650
    TKVNSTLTLE CESWAVPPPT IRWYKDGQPV TPSSRLQVLG EGRLLQIQPT 2700
    QVSDSGRYLC VATNVAGEDD QDFNVLIQVP PMFQKVGDFS AAFEILSREE 2750
    EARGGVTEYR EIVENNPAYL YCDTNAIPPP DLTWYREDQP LSAGDEVSVL 2800
    QGGRVLQIPL VRAENAGRYS CKASNEVGED WLHYELLVLT PPVILGDTEE 2850
    LVEEVTVNAS STVSLQCPAL GNPVPTISWL QNGLPFSPSP RLQVLEDGQV 2900
    LQVSTAEVAD AASYMCVAEN QAGSAEKLFT LRVQVPPRIA GLDLEQVTAI 2950
    LNSSVSLPCD VHAHPNPEVT WYKDSQALSL GEEVFLLPGT HTLQLGRARL 3000
    SDSGMYTCEA LNAAGRDQKL VQLSVLVPPA FRQAPRGPQD AVLVRVGDKA 3050
    VLSCETDALP EPTVTWYKDG QPLVLAQRTQ ALRGGQRLEI QEAQVSDKGL 3100
    YSCKVSNVAG EAVRTFTLTV QVPPTFENPK TETVSQVAGS PLVLTCDVSG 3150
    VPAPTVTWLK DRMPVESSAV HGVVSRGGRL QLSRLQPAQA GTYTCVAENT 3200
    QAEARKDFVV AVLVAPRIRS SGVAREHHVL EGQEVRLDCE ADGQPPPDVA 3250
    WLKDGSPLGQ DMGPHLRFYL DGGSLVLKGL RASDAGAYTC VAHNPAGEDA 3300
    RLHTVNVLVP PTIKQGADGS GTLVSRPGEL VTMVCPVRGS PPIHVSWLKD 3350
    GLPLPLSQRT LLHGSGHTLR ISKVQLADAG IFTCVAASPA GVADRNFTLQ 3400
    VQVPPVLEPV EFQNDVVVVR GSLVELPCEA RGVPLPLVSW MKDGEPLLSQ 3450
    SLEQGPSLQL EAVGAGDSGT YSCVAVSEAG EARRHFQLTV MEPPHIEDSG 3500
    QPTELSLTPG APMELLCDAQ GTPQPNITWH KDGQALTRLE NNSRATRVLR 3550
    VRDAGLYTCL AESPAGAIEK SFRVRVQAPP NIVGPRGPRF VVGLAPGQLV 3600
    LECSVEAEPA PKITWHRDGI VLQEDAHTQF PERGRFLQLQ ALSTADSGDY 3650
    SCTARNAAGS TSVAFRVEIH TVPTIRSGPP AVNVSVNQTA LLPCQADGVP 3700
    APLVSWRKDR VPLDPRSPRF EILPEGSLRI QPVLAQDAGH YLCLASNSAG 3750
    SDRQGRDLRV LEPPAIAPSP SNLTLTAHTP ALLPCEASGS PKPLVVWWKD 3800
    GQKLDFRLQQ GAYRLLPSNA LLLTAPGPQD SAQFECVVSN EVGEAHRLYQ 3850
    VTVHVPPTIA DDQTDFTVTM MAPVVLTCHS TGIPAPTVSW SKAGAQLGAR 3900
    GSGYRVSPSG ALEIGQALPI HAGRYTCSAR NSAGVAHKHV FLTVQASPVV 3950
    KPLPSVVRAV AEEEVLLPCE ASGIPRPTIT WQKEGLNVAT GVSTQVLPGG 4000
    QLRIAHASPE DAGNYLCIAK NSAGSAMGKT RLVVQVPPVI ENGLPDLSTT 4050
    EGSHAFLPCK ARGSPEPNIT WDKDGQPVSG AEGKFTIQPS GELLVKNLEG 4100
    QDAGTYTCTA ENAVGRARRR VHLTILVLPV FTTLPGDRSL RLGDRLWLRC 4150
    AARGSPTPRI GWTVNDRPVT EGVSEQDGGS TLQRAAVSRE DSGTYVCWAE 4200
    NRVGRTQAVS FVHVKEAPVL QGEAFSYLVE PVGGSIQLDC VVRGDPVPDI 4250
    HWIKDGLPLR GSHLRHQLQN GSLTIHRTER DDAGRYQCLA ENEMGVAKKV 4300
    VILVLQSAPV FQVEPQDMTV RSGDDVALRC QATGEPTPTI EWLQAGQPLR 4350
    ASRRLRTLPD GSLWLENVET GDAGTYDCVA HNLLGSATAR AFLVVRGEPQ 4400
    GSWGSMTGVI NGRKFGVATL NTSVMQEAHS GVSSIHSSIR HVPANVGPLM 4450
    RVLVVTIAPI YWALARESGE ALNGHSLTGG RFRQESHVEF ATGELLTMTQ 4500
    VARGLDPDGL LLLDVVVNGV VPESLADADL QVQDFEEHYV QTGPGQLFVG 4550
    STQRFFQGGL PSFLRCNHSI QYNAARGPQP QLVQHLRASA ISSAFDPEAE 4600
    ALRFQLATAL QAEENEVGCP EGFELDSQGA FCVDRDECSG GPSPCSHACL 4650
    NAPGRFSCTC PTGFALAWDD RNCRDVDECA WDAHLCREGQ RCVNLLGSYR 4700
    CLPDCGPGFR VADGAGCEDV DECLEGLDDC HYNQLCENTP GGHRCSCPRG 4750
    YRMQGPSLPC LDVNECLQLP KACAYQCHNL QGSYRCLCPP GQTLLRDGKA 4800
    CTSLERNGQN VTTVSHRGPL LPWLRPWASI PGTSYHAWVS LRPGPMALSS 4850
    VGRAWCPPGF IRQNGVCTDL DECRVRNLCQ HACRNTEGSY QCLCPAGYRL 4900
    LPSGKNCQDI NECEEESIEC GPGQMCFNTR GSYQCVDTPC PATYRQGPSP 4950
    GTCFRRCSQD CGTGGPSTLQ YRLLPLPLGV RAHHDVARLT AFSEVGVPAN 5000
    RTELSMLEPD PRSPFALRPL RAGLGAVYTR RALTRAGLYR LTVRAAAPRH 5050
    QSVFVLLIAV SPYPY 5065
    Length:5,065
    Mass (Da):542,605
    Last modified:June 15, 2010 - v2
    Checksum:i9819758773E9051E
    GO
    Isoform 2 (identifier: Q8NDA2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         4171-4198: EGVSEQDGGSTLQRAAVSREDSGTYVCW → GLGLLGMGGTESQDTGRLRREGRWGDPT
         4199-5065: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:4,198
    Mass (Da):448,332
    Checksum:iE5A1ACDF3CABD317
    GO
    Isoform 3 (identifier: Q8NDA2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         3401-3440: VQVPPVLEPV...RGVPLPLVSW → CPLSWSRWSS...GAFPCLSCRG
         3550-3550: R → RVENVQ
         3762-3780: Missing.
         4398-4757: EPQGSWGSMT...PRGYRMQGPS → MGHPCLDLRGQRQDLLPMGIVWCLWETCP
         4761-4767: Missing.
         4771-5065: KACAYQCHNL...LLIAVSPYPY → TSSLCFITSPE

    Note: No experimental confirmation available.

    Show »
    Length:4,427
    Mass (Da):474,146
    Checksum:i378B87433B805BF9
    GO

    Sequence cautioni

    The sequence BAB85069.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC04201.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence EAW87931.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3281 – 32811R → W in CAD38854. (PubMed:17974005)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei3401 – 344040VQVPP…PLVSW → CPLSWSRWSSRMTWWWFVAP WWNSRARPGAFPCLSCRG in isoform 3. 1 PublicationVSP_039364Add
    BLAST
    Alternative sequencei3550 – 35501R → RVENVQ in isoform 3. 1 PublicationVSP_039365
    Alternative sequencei3762 – 378019Missing in isoform 3. 1 PublicationVSP_039366Add
    BLAST
    Alternative sequencei4171 – 419828EGVSE…TYVCW → GLGLLGMGGTESQDTGRLRR EGRWGDPT in isoform 2. 1 PublicationVSP_039367Add
    BLAST
    Alternative sequencei4199 – 5065867Missing in isoform 2. 1 PublicationVSP_039368Add
    BLAST
    Alternative sequencei4398 – 4757360EPQGS…MQGPS → MGHPCLDLRGQRQDLLPMGI VWCLWETCP in isoform 3. 1 PublicationVSP_039369Add
    BLAST
    Alternative sequencei4761 – 47677Missing in isoform 3. 1 PublicationVSP_039370
    Alternative sequencei4771 – 5065295KACAY…SPYPY → TSSLCFITSPE in isoform 3. 1 PublicationVSP_039371Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL354898 Genomic DNA. No translation available.
    AL360004 Genomic DNA. No translation available.
    CH471090 Genomic DNA. Translation: EAW87931.1. Sequence problems.
    AK074396 mRNA. Translation: BAB85069.1. Different initiation.
    AK093583 mRNA. Translation: BAC04201.1. Different initiation.
    AL834139 mRNA. Translation: CAD38854.1.
    UniGeneiHs.32194.
    Hs.512559.

    Genome annotation databases

    EnsembliENST00000302481; ENSP00000305590; ENSG00000148357.

    Polymorphism databases

    DMDMi298351848.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL354898 Genomic DNA. No translation available.
    AL360004 Genomic DNA. No translation available.
    CH471090 Genomic DNA. Translation: EAW87931.1 . Sequence problems.
    AK074396 mRNA. Translation: BAB85069.1 . Different initiation.
    AK093583 mRNA. Translation: BAC04201.1 . Different initiation.
    AL834139 mRNA. Translation: CAD38854.1 .
    UniGenei Hs.32194.
    Hs.512559.

    3D structure databases

    ProteinModelPortali Q8NDA2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000277491.

    PTM databases

    PhosphoSitei Q8NDA2.

    Polymorphism databases

    DMDMi 298351848.

    Proteomic databases

    PaxDbi Q8NDA2.
    PRIDEi Q8NDA2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302481 ; ENSP00000305590 ; ENSG00000148357 .

    Organism-specific databases

    GeneCardsi GC09P133029.
    H-InvDB HIX0008467.
    HGNCi HGNC:21293. HMCN2.
    HPAi HPA053903.
    HPA060387.
    neXtProti NX_Q8NDA2.
    PharmGKBi PA142671680.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000172035.
    HOVERGENi HBG073398.
    OrthoDBi EOG78D7KD.
    PhylomeDBi Q8NDA2.

    Miscellaneous databases

    PROi Q8NDA2.

    Gene expression databases

    ArrayExpressi Q8NDA2.
    Bgeei Q8NDA2.

    Family and domain databases

    Gene3Di 2.40.155.10. 1 hit.
    2.60.40.10. 42 hits.
    InterProi IPR026823. cEGF.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR006605. G2_nidogen/fibulin_G2F.
    IPR009017. GFP.
    IPR023413. GFP_like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF12662. cEGF. 1 hit.
    PF07645. EGF_CA. 4 hits.
    PF07474. G2F. 1 hit.
    PF07679. I-set. 39 hits.
    [Graphical view ]
    SMARTi SM00179. EGF_CA. 6 hits.
    SM00409. IG. 2 hits.
    SM00408. IGc2. 40 hits.
    SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    SSF54511. SSF54511. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 5 hits.
    PS01187. EGF_CA. 5 hits.
    PS50835. IG_LIKE. 40 hits.
    PS50993. NIDOGEN_G2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3793-4508 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4762-5065 (ISOFORM 1).
      Tissue: Small intestine and Thymus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3088-5065 (ISOFORM 3).
      Tissue: Testis.

    Entry informationi

    Entry nameiHMCN2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NDA2
    Secondary accession number(s): Q8N225, Q8TCI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3