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Protein

Hemicentin-2

Gene

HMCN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sensory transduction

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Hemicentin-2Curated
Gene namesi
Name:HMCN2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:21293. HMCN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671680.

Polymorphism and mutation databases

DMDMi298351848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 50595037Hemicentin-2PRO_0000395108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi328 – 3281N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi345 – 3451N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi378 – 3781N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi477 – 4771N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi524 – 5241N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi537 ↔ 586PROSITE-ProRule annotation
Glycosylationi546 – 5461N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi628 ↔ 676PROSITE-ProRule annotation
Glycosylationi673 – 6731N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi718 ↔ 764PROSITE-ProRule annotation
Disulfide bondi806 ↔ 861PROSITE-ProRule annotation
Disulfide bondi905 ↔ 954PROSITE-ProRule annotation
Disulfide bondi996 ↔ 1045PROSITE-ProRule annotation
Glycosylationi1023 – 10231N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi1071 – 10711N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi1094 ↔ 1143PROSITE-ProRule annotation
Disulfide bondi1185 ↔ 1228PROSITE-ProRule annotation
Glycosylationi1267 – 12671N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi1272 ↔ 1322PROSITE-ProRule annotation
Glycosylationi1353 – 13531N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi1366 ↔ 1415PROSITE-ProRule annotation
Disulfide bondi1459 ↔ 1509PROSITE-ProRule annotation
Glycosylationi1536 – 15361N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi1553 ↔ 1602PROSITE-ProRule annotation
Glycosylationi1562 – 15621N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi1647 ↔ 1696PROSITE-ProRule annotation
Glycosylationi1670 – 16701N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi1740 ↔ 1789PROSITE-ProRule annotation
Glycosylationi1819 – 18191N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi1832 ↔ 1873PROSITE-ProRule annotation
Glycosylationi1908 – 19081N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi1915 ↔ 1964PROSITE-ProRule annotation
Disulfide bondi2007 ↔ 2058PROSITE-ProRule annotation
Glycosylationi2008 – 20081N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi2087 – 20871N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi2093 – 20931N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi2100 ↔ 2149PROSITE-ProRule annotation
Disulfide bondi2192 ↔ 2243PROSITE-ProRule annotation
Glycosylationi2251 – 22511N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi2288 ↔ 2337PROSITE-ProRule annotation
Glycosylationi2289 – 22891N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi2369 – 23691N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi2382 ↔ 2431PROSITE-ProRule annotation
Glycosylationi2443 – 24431N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi2475 ↔ 2524PROSITE-ProRule annotation
Glycosylationi2476 – 24761N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi2515 – 25151N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi2571 ↔ 2620PROSITE-ProRule annotation
Glycosylationi2580 – 25801N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi2662 – 26621N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi2669 ↔ 2718PROSITE-ProRule annotation
Disulfide bondi2780 ↔ 2829PROSITE-ProRule annotation
Glycosylationi2866 – 28661N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi2875 ↔ 2924PROSITE-ProRule annotation
Glycosylationi2960 – 29601N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi2967 ↔ 3016PROSITE-ProRule annotation
Disulfide bondi3062 ↔ 3111PROSITE-ProRule annotation
Disulfide bondi3154 ↔ 3203PROSITE-ProRule annotation
Disulfide bondi3247 ↔ 3298PROSITE-ProRule annotation
Disulfide bondi3343 ↔ 3392PROSITE-ProRule annotation
Glycosylationi3404 – 34041N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi3436 ↔ 3481PROSITE-ProRule annotation
Disulfide bondi3525 ↔ 3572PROSITE-ProRule annotation
Glycosylationi3534 – 35341N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi3549 – 35491N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi3616 ↔ 3665PROSITE-ProRule annotation
Glycosylationi3696 – 36961N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi3700 – 37001N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi3707 ↔ 3756PROSITE-ProRule annotation
Disulfide bondi3779 ↔ 3830PROSITE-ProRule annotation
Disulfide bondi3872 ↔ 3921PROSITE-ProRule annotation
Disulfide bondi3963 ↔ 4011PROSITE-ProRule annotation
Disulfide bondi4053 ↔ 4102PROSITE-ProRule annotation
Glycosylationi4062 – 40621N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi4144 ↔ 4191PROSITE-ProRule annotation
Disulfide bondi4234 ↔ 4282PROSITE-ProRule annotation
Glycosylationi4264 – 42641N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi4324 ↔ 4372PROSITE-ProRule annotation
Glycosylationi4415 – 44151N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi4561 – 45611N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi4632 ↔ 4643PROSITE-ProRule annotation
Disulfide bondi4639 ↔ 4652PROSITE-ProRule annotation
Disulfide bondi4654 ↔ 4667PROSITE-ProRule annotation
Disulfide bondi4673 ↔ 4686PROSITE-ProRule annotation
Disulfide bondi4680 ↔ 4695PROSITE-ProRule annotation
Disulfide bondi4699 ↔ 4711PROSITE-ProRule annotation
Disulfide bondi4717 ↔ 4730PROSITE-ProRule annotation
Disulfide bondi4724 ↔ 4739PROSITE-ProRule annotation
Disulfide bondi4760 ↔ 4771PROSITE-ProRule annotation
Disulfide bondi4767 ↔ 4780PROSITE-ProRule annotation
Disulfide bondi4782 ↔ 4795PROSITE-ProRule annotation
Glycosylationi4804 – 48041N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi4867 ↔ 4877PROSITE-ProRule annotation
Disulfide bondi4873 ↔ 4886PROSITE-ProRule annotation
Disulfide bondi4888 ↔ 4901PROSITE-ProRule annotation
Glycosylationi4994 – 49941N-linked (GlcNAc...)PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8NDA2.
PRIDEiQ8NDA2.

PTM databases

PhosphoSiteiQ8NDA2.

Expressioni

Gene expression databases

BgeeiQ8NDA2.

Organism-specific databases

HPAiHPA053903.
HPA060387.

Structurei

3D structure databases

ProteinModelPortaliQ8NDA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 205168VWFAAdd
BLAST
Domaini517 – 60286Ig-like C2-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini607 – 69084Ig-like C2-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini697 – 78084Ig-like C2-type 3PROSITE-ProRule annotationAdd
BLAST
Domaini785 – 87995Ig-like C2-type 4PROSITE-ProRule annotationAdd
BLAST
Domaini884 – 97087Ig-like C2-type 5PROSITE-ProRule annotationAdd
BLAST
Domaini975 – 106187Ig-like C2-type 6PROSITE-ProRule annotationAdd
BLAST
Domaini1066 – 115994Ig-like C2-type 7PROSITE-ProRule annotationAdd
BLAST
Domaini1164 – 124481Ig-like C2-type 8PROSITE-ProRule annotationAdd
BLAST
Domaini1265 – 133874Ig-like C2-type 9PROSITE-ProRule annotationAdd
BLAST
Domaini1343 – 142987Ig-like C2-type 10PROSITE-ProRule annotationAdd
BLAST
Domaini1436 – 152590Ig-like C2-type 11PROSITE-ProRule annotationAdd
BLAST
Domaini1530 – 161889Ig-like C2-type 12PROSITE-ProRule annotationAdd
BLAST
Domaini1623 – 171492Ig-like C2-type 13PROSITE-ProRule annotationAdd
BLAST
Domaini1717 – 180589Ig-like C2-type 14PROSITE-ProRule annotationAdd
BLAST
Domaini1810 – 188778Ig-like C2-type 15PROSITE-ProRule annotationAdd
BLAST
Domaini1894 – 198289Ig-like C2-type 16PROSITE-ProRule annotationAdd
BLAST
Domaini1985 – 207490Ig-like C2-type 17PROSITE-ProRule annotationAdd
BLAST
Domaini2079 – 216587Ig-like C2-type 18PROSITE-ProRule annotationAdd
BLAST
Domaini2170 – 226192Ig-like C2-type 19PROSITE-ProRule annotationAdd
BLAST
Domaini2264 – 235390Ig-like C2-type 20PROSITE-ProRule annotationAdd
BLAST
Domaini2358 – 244790Ig-like C2-type 21PROSITE-ProRule annotationAdd
BLAST
Domaini2452 – 254089Ig-like C2-type 22PROSITE-ProRule annotationAdd
BLAST
Domaini2545 – 263692Ig-like C2-type 23PROSITE-ProRule annotationAdd
BLAST
Domaini2641 – 273292Ig-like C2-type 24PROSITE-ProRule annotationAdd
BLAST
Domaini2739 – 283395Ig-like C2-type 25PROSITE-ProRule annotationAdd
BLAST
Domaini2849 – 293890Ig-like C2-type 26PROSITE-ProRule annotationAdd
BLAST
Domaini2945 – 303288Ig-like C2-type 27PROSITE-ProRule annotationAdd
BLAST
Domaini3037 – 312791Ig-like C2-type 28PROSITE-ProRule annotationAdd
BLAST
Domaini3131 – 321989Ig-like C2-type 29PROSITE-ProRule annotationAdd
BLAST
Domaini3224 – 331491Ig-like C2-type 30PROSITE-ProRule annotationAdd
BLAST
Domaini3319 – 340688Ig-like C2-type 31PROSITE-ProRule annotationAdd
BLAST
Domaini3412 – 349786Ig-like C2-type 32PROSITE-ProRule annotationAdd
BLAST
Domaini3502 – 358887Ig-like C2-type 33PROSITE-ProRule annotationAdd
BLAST
Domaini3593 – 368189Ig-like C2-type 34PROSITE-ProRule annotationAdd
BLAST
Domaini3686 – 377287Ig-like C2-type 35PROSITE-ProRule annotationAdd
BLAST
Domaini3777 – 384872Ig-like C2-type 36PROSITE-ProRule annotationAdd
BLAST
Domaini3851 – 393787Ig-like C2-type 37PROSITE-ProRule annotationAdd
BLAST
Domaini3942 – 402786Ig-like C2-type 38PROSITE-ProRule annotationAdd
BLAST
Domaini4031 – 411888Ig-like C2-type 39PROSITE-ProRule annotationAdd
BLAST
Domaini4123 – 420482Ig-like C2-type 40PROSITE-ProRule annotationAdd
BLAST
Domaini4212 – 429584Ig-like C2-type 41PROSITE-ProRule annotationAdd
BLAST
Domaini4303 – 438886Ig-like C2-type 42PROSITE-ProRule annotationAdd
BLAST
Domaini4392 – 4614223Nidogen G2 beta-barrelPROSITE-ProRule annotationAdd
BLAST
Domaini4628 – 466841EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini4669 – 471244EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini4713 – 475139EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini4756 – 479641EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini4863 – 490240EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 EGF-like domains.PROSITE-ProRule annotation
Contains 42 Ig-like C2-type (immunoglobulin-like) domains.PROSITE-ProRule annotation
Contains 1 nidogen G2 beta-barrel domain.PROSITE-ProRule annotation
Contains 1 VWFA domain.Curated

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00840000129685.
HOGENOMiHOG000172035.
HOVERGENiHBG073398.
InParanoidiQ8NDA2.
OrthoDBiEOG78D7KD.
PhylomeDBiQ8NDA2.

Family and domain databases

Gene3Di2.40.155.10. 1 hit.
2.60.40.10. 45 hits.
InterProiIPR026823. cEGF.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR006605. G2_nidogen/fibulin_G2F.
IPR009017. GFP.
IPR023413. GFP-like.
IPR009030. Growth_fac_rcpt_.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR002035. VWF_A.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 4 hits.
PF07474. G2F. 1 hit.
PF07679. I-set. 32 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
SM00179. EGF_CA. 6 hits.
SM00682. G2F. 1 hit.
SM00409. IG. 43 hits.
SM00408. IGc2. 43 hits.
SM00406. IGv. 14 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 43 hits.
SSF53300. SSF53300. 1 hit.
SSF54511. SSF54511. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 5 hits.
PS50835. IG_LIKE. 42 hits.
PS50993. NIDOGEN_G2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NDA2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MPGAPLLRLL TAVSAAVAVA VAGAPGTVMP PTTGDATLAF VFDVTGSMWD
60 70 80 90 100
ELMQVIDGAS RILERSLSRR SQAIANYALV PFHDPDIGPV TLTADPTVFQ
110 120 130 140 150
RELRELYVQG GGDCPEMSVG AIKAAVEVAN PGSFIYVFSD ARAKDYHKKE
160 170 180 190 200
ELLRLLQLKQ SQVVFVLTGD CGDRTHPGYL AYEEIAATSS GQVFHLDKQQ
210 220 230 240 250
VTEVLKWVES AIQASKVHLL STDHEEEGEH TWRLPFDPSL KEVTISLSGP
260 270 280 290 300
GPEIEVQDPL GRILQEDEGL NVLLNIPDSA KVVAFKPEHP GLWSIKVYSS
310 320 330 340 350
GRHSVRITGV SNIDFRAGFS TQPLLDLNHT LEWPLQGVPI SLVINSTGLK
360 370 380 390 400
APGRLDSVEL AQSSGKPLLT LPTKPLSNGS THQLWGGPPF HTPKERFYLK
410 420 430 440 450
VKGKDHEGNP LLRVSGVSYS GVAPGAPLVS MAPRIHGYLH QPLLVSCSVH
460 470 480 490 500
SALPFRLQLR RGEARLGEER HFQESGNSSW EILRASKAEE GTYECTAVSR
510 520 530 540 550
AGTGRAKAQI VVTDPPPQLV PAPNVTVSPG ETAVLSCRVL GEAPYNLTWV
560 570 580 590 600
RDWRVLPAST GRVAQLADLS LEISGIIPTD GGRYQCVASN ANGVTRASVW
610 620 630 640 650
LLVREAPQVS IHTSSQHFSQ GVEVKVSCSA SGYPTPHISW SRESQALQED
660 670 680 690 700
SRIHVDAQGT LIIQGVAPED AGNYSCQATN EVGTDQETVT LYYTDPPSVS
710 720 730 740 750
AVNAVVLVAV GEEAVLVCEA SGVPPPRVIW YRGGLEMILA PEGSSSGKLR
760 770 780 790 800
IPAAQERDAG TYTCRAVNEL GDASAEIQLA VGHAPQLTEL PRDVTVELGR
810 820 830 840 850
SALLACRATG RPPPTVTWRR GDGQPLGLRL GAGRGSRSRQ PDSGVLFFES
860 870 880 890 900
VAPEDQAPYV CEARNVFGKV QAEARLIVTG HAPPQIASSA PTVRVLEGQP
910 920 930 940 950
VSLPCIVLAG RPLPERHWLK DGRPLPPGSR HSIRADGSLH LDRALQEHAG
960 970 980 990 1000
RYSCVATNTA GSQHRDVELV VQVPPRIHPT ATHHITNEGV AASLPCVASG
1010 1020 1030 1040 1050
VPAPTITWTK ETNALTSRGP HYNVSKEGTL LIAQPSAQDA GAYVCTATNT
1060 1070 1080 1090 1100
VGFSSQEMRL SVNTKPRIHM NGSRNADVPL QVTAKAGEEV TLDCEAKGSP
1110 1120 1130 1140 1150
PPLVTWTKDS RPVPPITNRY GLLPSGSLRL AQVQVGDSGH YECTASNPAG
1160 1170 1180 1190 1200
SASHRYVLGV QVPPQVQPGP RVLKVLVGEA LDLNCVAEGN PEPQLSWSKD
1210 1220 1230 1240 1250
GVVLQGRGPQ GSVHFAAIRT SDAGRYRCEA SNSAGVDAWE VELRVLEPPH
1260 1270 1280 1290 1300
WGADETSGLL ERVAGENASL PCPARGTPKP QVTWRKGPSS EPLHGQPGVA
1310 1320 1330 1340 1350
VLEEGSLFLA SVSPADSGDY ECQATNEVGS TSRRAKLVVY VPPSIREDGR
1360 1370 1380 1390 1400
KANVSGMAGQ SLTLECDANG FPVPEIVWLK DAQLIPKVGG HRLLDEGQSL
1410 1420 1430 1440 1450
HFPRIQEGDS GLYSCRAENQ AGTAQRDFHL LVLTPPSVLG AGAAQEVLGL
1460 1470 1480 1490 1500
AGADVELQCW TSGVPTPQVE WTKDRQPVLP GGPHLQVQED GQVLRITGSH
1510 1520 1530 1540 1550
VGDEGRYQCV AFSPAGQQAR DFQLRVHAPP TIWGSNETGE VAVMEDHLVQ
1560 1570 1580 1590 1600
LLCEARGVPT PNITWFKDGA LLPTSTKVVY TRGGRQLQLG RAQSSDAGVY
1610 1620 1630 1640 1650
TCKASNAVGA AEKATRLDVY VPPTIEGAGG RPYVVKAVAG RPVALECVAR
1660 1670 1680 1690 1700
GHPSPTLSWH HEGLPVAESN ESRLETDGSV LRLESPGEAS SGLYSCVASS
1710 1720 1730 1740 1750
PAGEAVLQYS VEVQVPPQLL VAEGLGQVTT IVGQPLELPC QASGSPVPTI
1760 1770 1780 1790 1800
QWLQNGRPAE ELAGVQVASQ GTTLHIDHVE LDHSGLFACQ ATNEAGTAGA
1810 1820 1830 1840 1850
EVEVSVHEFP SVSIIGGENI TAPFLQPVTL QCIGDGVPTP SLRWWKDGVA
1860 1870 1880 1890 1900
LAAFGGNLQI EKVDLRDEGI YTCAATNLAG ESKREVALKV LVPPNIEPGP
1910 1920 1930 1940 1950
VNKAVLENAS VTLECLASGV PPPDVSWFKG HQPVSSWMGV TVSVDGRVLR
1960 1970 1980 1990 2000
IEQAQLSDAG SYRCVASNVA GSTELRYGLR VNVPPRITLP PSLPGPVLVN
2010 2020 2030 2040 2050
TPVRLTCNAT GAPSPTLMWL KDGNPVSPAG TPGLQVFPGG RVLTLASARA
2060 2070 2080 2090 2100
SDSGRYSCVA VSAVGEDRQD VVLQVHMPPS ILGEELNVSV VANESVALEC
2110 2120 2130 2140 2150
QSHAMPPPVL SWWKDGRPLE PRPGVHLSAD KALLQVDRAD VWDAGHYTCE
2160 2170 2180 2190 2200
ALNQAGHSEK HYNLNVWVAP VFPLRESHTL TVREGHPTRL SCECRGVPFP
2210 2220 2230 2240 2250
KISWRKDGQP LPGEGAGLQH VSAVGRLLYL GQAQLAQEGT YTCECSNVVG
2260 2270 2280 2290 2300
NSSQDLQLEV HVPPQIAGPR EPPTQVSVVQ DGVATLECNA TGKPPPTVTW
2310 2320 2330 2340 2350
ERDGQPVGAE LGLQLQNQGQ SLHVERAQAA HTGRYSCVAE NLAGRAERKF
2360 2370 2380 2390 2400
ELSVLVPPEL IGDLDPLTNI TAALHSPLTL LCEAMGIPPP AIRWFRGEEP
2410 2420 2430 2440 2450
VSPGEDTYLL AGGWMLKMTQ TQEQDSGLYS CLASNEAGEA RRNFSVEVLV
2460 2470 2480 2490 2500
PPSIENEDLE EVIKVLDGQT AHLMCNVTGH PQPKLTWFKD GRPLARGDAH
2510 2520 2530 2540 2550
HISPDGVLLQ VLQANLSSAG HYSCIAANAV GEKTKHFQLS VLLAPTILGG
2560 2570 2580 2590 2600
AEDSADEEVT VTVNNPISLI CEALAFPSPN ITWMKDGAPF EASRNIQLLP
2610 2620 2630 2640 2650
GTHGLQILNA QKEDAGQYTC VVTNELGEAV KNYHVEVLIP PSISKDDPLA
2660 2670 2680 2690 2700
EVGVKEVKTK VNSTLTLECE SWAVPPPTIR WYKDGQPVTP SSRLQVLGEG
2710 2720 2730 2740 2750
RLLQIQPTQV SDSGRYLCVA TNVAGEDDQD FNVLIQVPPM FQKVGDFSAA
2760 2770 2780 2790 2800
FEILSREEEA RGGVTEYREI VENNPAYLYC DTNAIPPPDL TWYREDQPLS
2810 2820 2830 2840 2850
AGDEVSVLQG GRVLQIPLVR AENAGRYSCK ASNEVGEDWL HYELLVLTPP
2860 2870 2880 2890 2900
VILGDTEELV EEVTVNASST VSLQCPALGN PVPTISWLQN GLPFSPSPRL
2910 2920 2930 2940 2950
QVLEDGQVLQ VSTAEVADAA SYMCVAENQA GSAEKLFTLR VQVPPRIAGL
2960 2970 2980 2990 3000
DLEQVTAILN SSVSLPCDVH AHPNPEVTWY KDSQALSLGE EVFLLPGTHT
3010 3020 3030 3040 3050
LQLGRARLSD SGMYTCEALN AAGRDQKLVQ LSVLVPPAFR QAPRGPQDAV
3060 3070 3080 3090 3100
LVRVGDKAVL SCETDALPEP TVTWYKDGQP LVLAQRTQAL RGGQRLEIQE
3110 3120 3130 3140 3150
AQVSDKGLYS CKVSNVAGEA VRTFTLTVQV PPTFENPKTE TVSQVAGSPL
3160 3170 3180 3190 3200
VLTCDVSGVP APTVTWLKDR MPVESSAVHG VVSRGGRLQL SRLQPAQAGT
3210 3220 3230 3240 3250
YTCVAENTQA EARKDFVVAV LVAPRIRSSG VAREHHVLEG QEVRLDCEAD
3260 3270 3280 3290 3300
GQPPPDVAWL KDGSPLGQDM GPHLRFYLDG GSLVLKGLRA SDAGAYTCVA
3310 3320 3330 3340 3350
HNPAGEDARL HTVNVLVPPT IKQGADGSGT LVSRPGELVT MVCPVRGSPP
3360 3370 3380 3390 3400
IHVSWLKDGL PLPLSQRTLL HGSGHTLRIS KVQLADAGIF TCVAASPAGV
3410 3420 3430 3440 3450
ADRNFTLQVQ VPPVLEPVEF QNDVVVVRGS LVELPCEARG VPLPLVSWMK
3460 3470 3480 3490 3500
DGEPLLSQSL EQGPSLQLEA VGAGDSGTYS CVAVSEAGEA RRHFQLTVME
3510 3520 3530 3540 3550
PPHIEDSGQP TELSLTPGAP MELLCDAQGT PQPNITWHKD GQALTRLENN
3560 3570 3580 3590 3600
SRATRVLRVE NVQVRDAGLY TCLAESPAGA IEKSFRVRVQ APPNIVGPRG
3610 3620 3630 3640 3650
PRFVVGLAPG QLVLECSVEA EPAPKITWHR DGIVLQEDAH TQFPERGRFL
3660 3670 3680 3690 3700
QLQALSTADS GDYSCTARNA AGSTSVAFRV EIHTVPTIRS GPPAVNVSVN
3710 3720 3730 3740 3750
QTALLPCQAD GVPAPLVSWR KDRVPLDPRS PRFEILPEGS LRIQPVLAQD
3760 3770 3780 3790 3800
AGHYLCLASN SAGSDRQGRD LRVLALLPCE ASGSPKPLVV WWKDGQKLDF
3810 3820 3830 3840 3850
RLQQGAYRLL PSNALLLTAP GPQDSAQFEC VVSNEVGEAH RLYQVTVHVP
3860 3870 3880 3890 3900
PTIADDQTDF TVTMMAPVVL TCHSTGIPAP TVSWSKAGAQ LGARGSGYRV
3910 3920 3930 3940 3950
SPSGALEIGQ ALPIHAGRYT CSARNSAGVA HKHVFLTVQA SPVVKPLPSV
3960 3970 3980 3990 4000
VRAVAEEEVL LPCEASGIPR PTITWQKEGL NVATGVSTQV LPGGQLRIAH
4010 4020 4030 4040 4050
ASPEDAGNYL CIAKNSAGSA MGKTRLVVQV PPVIENGLPD LSTTEGSHAF
4060 4070 4080 4090 4100
LPCKARGSPE PNITWDKDGQ PVSGAEGKFT IQPSGELLVK NLEGQDAGTY
4110 4120 4130 4140 4150
TCTAENAVGR ARRRVHLTIL VLPVFTTLPG DRSLRLGDRL WLRCAARGSP
4160 4170 4180 4190 4200
TPRIGWTVND RPVTEGVSEQ DGGSTLQRAA VSREDSGTYV CWAENRVGRT
4210 4220 4230 4240 4250
QAVSFVHVKE APVLQGEAFS YLVEPVGGSI QLDCVVRGDP VPDIHWIKDG
4260 4270 4280 4290 4300
LPLRGSHLRH QLQNGSLTIR RTERDDAGRY QCLAENEMGV AKKVVILVLQ
4310 4320 4330 4340 4350
SAPVFQVEPQ DMTVRSGDDV ALRCQATGEP TPTIEWLQAG QPLRASRRLR
4360 4370 4380 4390 4400
TLPDGSLWLE NVETGDAGTY DCVAHNLLGS ATARAFLVVR GEPQGSWGSM
4410 4420 4430 4440 4450
TGVINGRKFG VATLNTSVMQ EAHSGVSSIH SSIRHVPANV GPLMRVLVVT
4460 4470 4480 4490 4500
IAPIYWALAR ESGEALNGHS LTGGRFRQES HVEFATGELL TMTQVARGLD
4510 4520 4530 4540 4550
PDGLLLLDVV VNGVVPESLA DADLQVQDFE EHYVQTGPGQ LFVGSTQRFF
4560 4570 4580 4590 4600
QGGLPSFLRC NHSIQYNAAR GPQPQLVQHL RASAISSAFD PEAEALRFQL
4610 4620 4630 4640 4650
ATALQAEENE VGCPEGFELD SQGAFCVDRD ECSGGPSPCS HACLNAPGRF
4660 4670 4680 4690 4700
SCTCPTGFAL AWDDRNCRDV DECAWDAHLC REGQRCVNLL GSYRCLPDCG
4710 4720 4730 4740 4750
PGFRVADGAG CEDVDECLEG LDDCHYNQLC ENTPGGHRCS CPRGYRMQGP
4760 4770 4780 4790 4800
SLPCLDVNEC LQLPKACAYQ CHNLQGSYRC LCPPGQTLLR DGKACTSLER
4810 4820 4830 4840 4850
NGQNVTTVSH RGPLLPWLRP WASIPGTSYH AWVSLRPGPM ALSSVGRAWC
4860 4870 4880 4890 4900
PPGFIRQNGV CTDLDECRVR NLCQHACRNT EGSYQCLCPA GYRLLPSGKN
4910 4920 4930 4940 4950
CQDINECEEE SIECGPGQMC FNTRGSYQCV DTPCPATYRQ GPSPGTCFRR
4960 4970 4980 4990 5000
CSQDCGTGGP STLQYRLLPL PLGVRAHHDV ARLTAFSEVG VPANRTELSM
5010 5020 5030 5040 5050
LEPDPRSPFA LRPLRAGLGA VYTRRALTRA GLYRLTVRAA APRHQSVFVL

LIAVSPYPY
Length:5,059
Mass (Da):541,978
Last modified:April 13, 2016 - v3
Checksum:i5933D04A2F9AF3D7
GO
Isoform 2 (identifier: Q8NDA2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4165-4192: EGVSEQDGGSTLQRAAVSREDSGTYVCW → GLGLLGMGGTESQDTGRLRREGRWGDPT
     4193-5059: Missing.

Note: No experimental confirmation available.
Show »
Length:4,192
Mass (Da):447,686
Checksum:i21E7E4798F36F8A6
GO
Isoform 3 (identifier: Q8NDA2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3409-3446: VQVPPVLEPV...EARGVPLPLV → CPLSWSRWSS...GAFPCLSCRG
     3447-5059: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:3,446
Mass (Da):368,616
Checksum:i8CD5815988D0749A
GO

Sequence cautioni

The sequence BAB85069.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC04201.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD38854.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence EAW87931.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3289 – 32891R → W in CAD38854 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei3409 – 344638VQVPP…PLPLV → CPLSWSRWSSRMTWWWFVAP WWNSRARPGAFPCLSCRG in isoform 3. CuratedVSP_058197Add
BLAST
Alternative sequencei3447 – 50591613Missing in isoform 3. CuratedVSP_058198Add
BLAST
Alternative sequencei4165 – 419228EGVSE…TYVCW → GLGLLGMGGTESQDTGRLRR EGRWGDPT in isoform 2. 1 PublicationVSP_039367Add
BLAST
Alternative sequencei4193 – 5059867Missing in isoform 2. 1 PublicationVSP_039368Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABBA01012042 Genomic DNA. No translation available.
ABBA01043973 Genomic DNA. No translation available.
AL354898 Genomic DNA. No translation available.
AL360004 Genomic DNA. No translation available.
AUXG01000072 Genomic DNA. No translation available.
FP565345 Genomic DNA. No translation available.
KF458942 Genomic DNA. No translation available.
CH471090 Genomic DNA. Translation: EAW87931.1. Sequence problems.
AK074396 mRNA. Translation: BAB85069.1. Different initiation.
AK093583 mRNA. Translation: BAC04201.1. Different initiation.
AL834139 mRNA. Translation: CAD38854.1. Sequence problems.
UniGeneiHs.32194.
Hs.512559.

Genome annotation databases

EnsembliENST00000624552; ENSP00000485357; ENSG00000148357. [Q8NDA2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABBA01012042 Genomic DNA. No translation available.
ABBA01043973 Genomic DNA. No translation available.
AL354898 Genomic DNA. No translation available.
AL360004 Genomic DNA. No translation available.
AUXG01000072 Genomic DNA. No translation available.
FP565345 Genomic DNA. No translation available.
KF458942 Genomic DNA. No translation available.
CH471090 Genomic DNA. Translation: EAW87931.1. Sequence problems.
AK074396 mRNA. Translation: BAB85069.1. Different initiation.
AK093583 mRNA. Translation: BAC04201.1. Different initiation.
AL834139 mRNA. Translation: CAD38854.1. Sequence problems.
UniGeneiHs.32194.
Hs.512559.

3D structure databases

ProteinModelPortaliQ8NDA2.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8NDA2.

Polymorphism and mutation databases

DMDMi298351848.

Proteomic databases

EPDiQ8NDA2.
PRIDEiQ8NDA2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000624552; ENSP00000485357; ENSG00000148357. [Q8NDA2-1]

Organism-specific databases

GeneCardsiHMCN2.
H-InvDBHIX0008467.
HGNCiHGNC:21293. HMCN2.
HPAiHPA053903.
HPA060387.
neXtProtiNX_Q8NDA2.
PharmGKBiPA142671680.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00840000129685.
HOGENOMiHOG000172035.
HOVERGENiHBG073398.
InParanoidiQ8NDA2.
OrthoDBiEOG78D7KD.
PhylomeDBiQ8NDA2.

Miscellaneous databases

PROiQ8NDA2.

Gene expression databases

BgeeiQ8NDA2.

Family and domain databases

Gene3Di2.40.155.10. 1 hit.
2.60.40.10. 45 hits.
InterProiIPR026823. cEGF.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR006605. G2_nidogen/fibulin_G2F.
IPR009017. GFP.
IPR023413. GFP-like.
IPR009030. Growth_fac_rcpt_.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR002035. VWF_A.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 4 hits.
PF07474. G2F. 1 hit.
PF07679. I-set. 32 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
SM00179. EGF_CA. 6 hits.
SM00682. G2F. 1 hit.
SM00409. IG. 43 hits.
SM00408. IGc2. 43 hits.
SM00406. IGv. 14 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 43 hits.
SSF53300. SSF53300. 1 hit.
SSF54511. SSF54511. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 5 hits.
PS50835. IG_LIKE. 42 hits.
PS50993. NIDOGEN_G2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3787-5059 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4756-5059 (ISOFORM 1).
    Tissue: Small intestine and Thymus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3096-5059 (ISOFORM 3).
    Tissue: Testis.

Entry informationi

Entry nameiHMCN2_HUMAN
AccessioniPrimary (citable) accession number: Q8NDA2
Secondary accession number(s): A0A096LP30, Q8N225, Q8TCI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 13, 2016
Last modified: May 11, 2016
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.