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Q8NDA2 (HMCN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemicentin-2
Gene names
Name:HMCN2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length5065 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Sequence similarities

Contains 5 EGF-like domains.

Contains 42 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 nidogen G2 beta-barrel domain.

Contains 1 VWFA domain.

Sequence caution

The sequence BAB85069.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC04201.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence EAW87931.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processSensory transduction
   Cellular componentExtracellular matrix
Secreted
   Coding sequence diversityAlternative splicing
   DomainEGF-like domain
Immunoglobulin domain
Repeat
Signal
   LigandCalcium
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to stimulus

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NDA2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NDA2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     4171-4198: EGVSEQDGGSTLQRAAVSREDSGTYVCW → GLGLLGMGGTESQDTGRLRREGRWGDPT
     4199-5065: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8NDA2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     3401-3440: VQVPPVLEPV...RGVPLPLVSW → CPLSWSRWSS...GAFPCLSCRG
     3550-3550: R → RVENVQ
     3762-3780: Missing.
     4398-4757: EPQGSWGSMT...PRGYRMQGPS → MGHPCLDLRGQRQDLLPMGIVWCLWETCP
     4761-4767: Missing.
     4771-5065: KACAYQCHNL...LLIAVSPYPY → TSSLCFITSPE
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 50655042Hemicentin-2
PRO_0000395108

Regions

Domain36 – 210175VWFA
Domain518 – 60386Ig-like C2-type 1
Domain608 – 69184Ig-like C2-type 2
Domain698 – 78184Ig-like C2-type 3
Domain786 – 88095Ig-like C2-type 4
Domain885 – 97187Ig-like C2-type 5
Domain976 – 106287Ig-like C2-type 6
Domain1039 – 111577Ig-like C2-type 7
Domain1120 – 120081Ig-like C2-type 8
Domain1207 – 129488Ig-like C2-type 9
Domain1299 – 1400102Ig-like C2-type 10
Domain1407 – 149690Ig-like C2-type 11
Domain1501 – 158989Ig-like C2-type 12
Domain1594 – 168592Ig-like C2-type 13
Domain1688 – 177689Ig-like C2-type 14
Domain1783 – 187997Ig-like C2-type 15
Domain1886 – 197489Ig-like C2-type 16
Domain1977 – 206690Ig-like C2-type 17
Domain2071 – 215787Ig-like C2-type 18
Domain2162 – 225392Ig-like C2-type 19
Domain2256 – 234590Ig-like C2-type 20
Domain2350 – 243990Ig-like C2-type 21
Domain2444 – 253289Ig-like C2-type 22
Domain2537 – 262892Ig-like C2-type 23
Domain2633 – 272492Ig-like C2-type 24
Domain2731 – 2837107Ig-like C2-type 25
Domain2841 – 293090Ig-like C2-type 26
Domain2937 – 302488Ig-like C2-type 27
Domain3029 – 311991Ig-like C2-type 28
Domain3123 – 321189Ig-like C2-type 29
Domain3216 – 330691Ig-like C2-type 30
Domain3311 – 339888Ig-like C2-type 31
Domain3404 – 348986Ig-like C2-type 32
Domain3494 – 357582Ig-like C2-type 33
Domain3580 – 366889Ig-like C2-type 34
Domain3673 – 375987Ig-like C2-type 35
Domain3764 – 385491Ig-like C2-type 36
Domain3857 – 394387Ig-like C2-type 37
Domain3948 – 403386Ig-like C2-type 38
Domain4037 – 412488Ig-like C2-type 39
Domain4129 – 421082Ig-like C2-type 40
Domain4218 – 430184Ig-like C2-type 41
Domain4309 – 439486Ig-like C2-type 42
Domain4398 – 4620223Nidogen G2 beta-barrel
Domain4634 – 467441EGF-like 1; calcium-binding Potential
Domain4675 – 471844EGF-like 2; calcium-binding Potential
Domain4719 – 475739EGF-like 3; calcium-binding Potential
Domain4762 – 480241EGF-like 4; calcium-binding Potential
Domain4869 – 490840EGF-like 5; calcium-binding Potential

Amino acid modifications

Glycosylation3291N-linked (GlcNAc...) Potential
Glycosylation3461N-linked (GlcNAc...) Potential
Glycosylation3791N-linked (GlcNAc...) Potential
Glycosylation4781N-linked (GlcNAc...) Potential
Glycosylation5251N-linked (GlcNAc...) Potential
Glycosylation5471N-linked (GlcNAc...) Potential
Glycosylation6741N-linked (GlcNAc...) Potential
Glycosylation10241N-linked (GlcNAc...) Potential
Glycosylation12231N-linked (GlcNAc...) Potential
Glycosylation13091N-linked (GlcNAc...) Potential
Glycosylation15071N-linked (GlcNAc...) Potential
Glycosylation15331N-linked (GlcNAc...) Potential
Glycosylation16411N-linked (GlcNAc...) Potential
Glycosylation19001N-linked (GlcNAc...) Potential
Glycosylation20001N-linked (GlcNAc...) Potential
Glycosylation20791N-linked (GlcNAc...) Potential
Glycosylation20851N-linked (GlcNAc...) Potential
Glycosylation22431N-linked (GlcNAc...) Potential
Glycosylation22811N-linked (GlcNAc...) Potential
Glycosylation23611N-linked (GlcNAc...) Potential
Glycosylation24351N-linked (GlcNAc...) Potential
Glycosylation24681N-linked (GlcNAc...) Potential
Glycosylation25071N-linked (GlcNAc...) Potential
Glycosylation25721N-linked (GlcNAc...) Potential
Glycosylation26541N-linked (GlcNAc...) Potential
Glycosylation28581N-linked (GlcNAc...) Potential
Glycosylation29521N-linked (GlcNAc...) Potential
Glycosylation33961N-linked (GlcNAc...) Potential
Glycosylation35261N-linked (GlcNAc...) Potential
Glycosylation35411N-linked (GlcNAc...) Potential
Glycosylation36831N-linked (GlcNAc...) Potential
Glycosylation36871N-linked (GlcNAc...) Potential
Glycosylation37721N-linked (GlcNAc...) Potential
Glycosylation40681N-linked (GlcNAc...) Potential
Glycosylation42701N-linked (GlcNAc...) Potential
Glycosylation44211N-linked (GlcNAc...) Potential
Glycosylation45671N-linked (GlcNAc...) Potential
Glycosylation48101N-linked (GlcNAc...) Potential
Glycosylation50001N-linked (GlcNAc...) Potential
Disulfide bond538 ↔ 587 By similarity
Disulfide bond629 ↔ 677 By similarity
Disulfide bond719 ↔ 765 By similarity
Disulfide bond807 ↔ 862 By similarity
Disulfide bond906 ↔ 955 By similarity
Disulfide bond997 ↔ 1046 By similarity
Disulfide bond1141 ↔ 1184 By similarity
Disulfide bond1228 ↔ 1278 By similarity
Disulfide bond1322 ↔ 1386 By similarity
Disulfide bond1430 ↔ 1480 By similarity
Disulfide bond1524 ↔ 1573 By similarity
Disulfide bond1618 ↔ 1667 By similarity
Disulfide bond1711 ↔ 1760 By similarity
Disulfide bond1807 ↔ 1865 By similarity
Disulfide bond1907 ↔ 1956 By similarity
Disulfide bond1999 ↔ 2050 By similarity
Disulfide bond2092 ↔ 2141 By similarity
Disulfide bond2184 ↔ 2235 By similarity
Disulfide bond2280 ↔ 2329 By similarity
Disulfide bond2374 ↔ 2423 By similarity
Disulfide bond2467 ↔ 2516 By similarity
Disulfide bond2563 ↔ 2612 By similarity
Disulfide bond2661 ↔ 2710 By similarity
Disulfide bond2772 ↔ 2821 By similarity
Disulfide bond2867 ↔ 2916 By similarity
Disulfide bond2959 ↔ 3008 By similarity
Disulfide bond3054 ↔ 3103 By similarity
Disulfide bond3146 ↔ 3195 By similarity
Disulfide bond3239 ↔ 3290 By similarity
Disulfide bond3335 ↔ 3384 By similarity
Disulfide bond3428 ↔ 3473 By similarity
Disulfide bond3517 ↔ 3559 By similarity
Disulfide bond3603 ↔ 3652 By similarity
Disulfide bond3694 ↔ 3743 By similarity
Disulfide bond3785 ↔ 3836 By similarity
Disulfide bond3878 ↔ 3927 By similarity
Disulfide bond3969 ↔ 4017 By similarity
Disulfide bond4059 ↔ 4108 By similarity
Disulfide bond4150 ↔ 4197 By similarity
Disulfide bond4240 ↔ 4288 By similarity
Disulfide bond4330 ↔ 4378 By similarity
Disulfide bond4638 ↔ 4649 By similarity
Disulfide bond4645 ↔ 4658 By similarity
Disulfide bond4660 ↔ 4673 By similarity
Disulfide bond4679 ↔ 4692 By similarity
Disulfide bond4686 ↔ 4701 By similarity
Disulfide bond4705 ↔ 4717 By similarity
Disulfide bond4723 ↔ 4736 By similarity
Disulfide bond4730 ↔ 4745 By similarity
Disulfide bond4766 ↔ 4777 By similarity
Disulfide bond4773 ↔ 4786 By similarity
Disulfide bond4788 ↔ 4801 By similarity
Disulfide bond4873 ↔ 4883 By similarity
Disulfide bond4879 ↔ 4892 By similarity
Disulfide bond4894 ↔ 4907 By similarity

Natural variations

Alternative sequence3401 – 344040VQVPP…PLVSW → CPLSWSRWSSRMTWWWFVAP WWNSRARPGAFPCLSCRG in isoform 3.
VSP_039364
Alternative sequence35501R → RVENVQ in isoform 3.
VSP_039365
Alternative sequence3762 – 378019Missing in isoform 3.
VSP_039366
Alternative sequence4171 – 419828EGVSE…TYVCW → GLGLLGMGGTESQDTGRLRR EGRWGDPT in isoform 2.
VSP_039367
Alternative sequence4199 – 5065867Missing in isoform 2.
VSP_039368
Alternative sequence4398 – 4757360EPQGS…MQGPS → MGHPCLDLRGQRQDLLPMGI VWCLWETCP in isoform 3.
VSP_039369
Alternative sequence4761 – 47677Missing in isoform 3.
VSP_039370
Alternative sequence4771 – 5065295KACAY…SPYPY → TSSLCFITSPE in isoform 3.
VSP_039371

Experimental info

Sequence conflict32811R → W in CAD38854. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 15, 2010. Version 2.
Checksum: 9819758773E9051E

FASTA5,065542,605
        10         20         30         40         50         60 
MMPGAPLLRL LTAVSAAVAV AVAGAPGTVM PPTTGDATLA FVFDVTGSMW DELMQVIDGA 

        70         80         90        100        110        120 
SRILERSLSR RSQAIANYAL VPFHDPDIGP VTLTADPTVF QRELRELYVQ GGGDCPEMSV 

       130        140        150        160        170        180 
GAIKAAVEVA NPGSFIYVFS DARAKDYHKK EELLRLLQLK QSQVVFVLTG DCGDRTHPGY 

       190        200        210        220        230        240 
LAYEEIAATS SGQVFHLDKQ QVTEVLKWVE SAIQASKVHL LSTDHEEEGE HTWRLPFDPS 

       250        260        270        280        290        300 
LKEVTISLSG PGPEIEVQDP LGRILQEDEG LNVLLNIPDS AKVVAFKPEH PGLWSIKVYS 

       310        320        330        340        350        360 
SGRHSVRITG VSNIDFRAGF STQPLLDLNH TLEWPLQGVP ISLVINSTGL KAPGRLDSVE 

       370        380        390        400        410        420 
LAQSSGKPLL TLPTKPLSNG STHQLWGGPP FHTPKERFYL KVKGKDHEGN PLLRVSGVSY 

       430        440        450        460        470        480 
SGVAPGAPLV SMAPRIHGYL HQPLLVSCSV HSALPFRLQL RRGEARLGEE RHFQESGNSS 

       490        500        510        520        530        540 
WEILRASKAE EGTYECTAVS RAGTGRAKAQ IVVTDPPPQL VPAPNVTVSP GETAVLSCRV 

       550        560        570        580        590        600 
LGEAPYNLTW VRDWRVLPAS TGRVAQLADL SLEISGIIPT DGGRYQCVAS NANGVTRASV 

       610        620        630        640        650        660 
WLLVREAPQV SIHTSSQHFS QGVEVKVSCS ASGYPTPHIS WSRESQALQE DSRIHVDAQG 

       670        680        690        700        710        720 
TLIIQGVAPE DAGNYSCQAT NEVGTDQETV TLYYTDPPSV SAVNAVVLVA VGEEAVLVCE 

       730        740        750        760        770        780 
ASGVPPPRVI WYRGGLEMIL APEGSSSGKL RIPAAQERDA GTYTCRAVNE LGDASAEIQL 

       790        800        810        820        830        840 
AVGHAPQLTE LPRDVTVELG RSALLACRAT GRPPPTVTWR RGDGQPLGLR LGAGRGSRSR 

       850        860        870        880        890        900 
QPDSGVLFFE SVAPEDQAPY VCEARNVFGK VQAEARLIVT GHAPPQIASS APTVRVLEGQ 

       910        920        930        940        950        960 
PVSLPCIVLA GRPLPERHWL KDGRPLPPGS RHSIRADGSL HLDRALQEHA GRYSCVATNT 

       970        980        990       1000       1010       1020 
AGSQHRDVEL VVQVPPRIHP TATHHITNEG VPASLPCVAS GVPAPTITWT KETNALTSRG 

      1030       1040       1050       1060       1070       1080 
PHYNVSKEGT LLIAQPSAQD AGAYVCTATN TVGFSSQEMR LSVNRLALSK YVWEEYGLLP 

      1090       1100       1110       1120       1130       1140 
SGSLRLAQVQ VGDSGHYECT ASNPAGSASH RYVLGVQVPP QVQPGPRVLK VLVGEALDLN 

      1150       1160       1170       1180       1190       1200 
CVAEGNPEPQ LSWSKDGVVL QGRGPQGSVH FAAIRTSDAG RYRCEASNSA GVDAWEVELR 

      1210       1220       1230       1240       1250       1260 
VLEPPHWGAD ETSGLLERVA GENASLPCPA RGTPKPQVTW RKGPSSEPLH GQPGVAVLEE 

      1270       1280       1290       1300       1310       1320 
GSLFLASVSP ADSGDYECQA TNEVGSTSRR AKLVVYVPPS IREDGRKANV SGMAGQSLTL 

      1330       1340       1350       1360       1370       1380 
ECDANGFPVP EIVWLKDAQL VGVPLGWAGY GWDLGWGQVG GHRLLDEGQS LHFPRIQEGD 

      1390       1400       1410       1420       1430       1440 
SGLYSCRAEN QAGTAQRDFH LLVLTPPSVL GAGAAQEVLG LAGADVELQC WTSGVPTPQV 

      1450       1460       1470       1480       1490       1500 
EWTKDRQPVL PGGPHLQVQE DGQVLRITGS HVGDEGRYQC VAFSPAGQQA RDFQLRVHAP 

      1510       1520       1530       1540       1550       1560 
PTIWGSNETG EVAVMEDHLV QLLCEARGVP TPNITWFKDG ALLPTSTKVV YTRGGRQLQL 

      1570       1580       1590       1600       1610       1620 
GRAQSSDAGV YTCKASNAVG AAEKATRLDV YVPPTIEGAG GRPYVVKAVA GRPVALECVA 

      1630       1640       1650       1660       1670       1680 
RGHPSPTLSW HHEGLPVAES NESRLETDGS VLRLESPGEA SSGLYSCVAS SPAGEAVLQY 

      1690       1700       1710       1720       1730       1740 
SVEVQVPPQL LVAEGLGQVT TIVGQPLELP CQASGSPVPT IQWLQNGRPA EELAGVQVAS 

      1750       1760       1770       1780       1790       1800 
QGTTLHIDHV ELDHSGLFAC QATNEAGTAG AEVEVSVHGE WAPGVLEVPI GQYHWGXEHH 

      1810       1820       1830       1840       1850       1860 
SSFPAACDPP VHRGWGAHPK PPLVEGWCSP GSLWGEPTGI PVAYSLPPPL QIEKVDLRDE 

      1870       1880       1890       1900       1910       1920 
GIYTCAATNL AGESKREVAL KVLVPPNIEP GPVNKAVLEN ASVTLECLAS GVPPPDVSWF 

      1930       1940       1950       1960       1970       1980 
KGHQPVSSWM GVTVSVDGRV LRIEQAQLSD AGSYRCVASN VAGSTELRYG LRVNVPPRIT 

      1990       2000       2010       2020       2030       2040 
LPPSLPGPVL VNTPVRLTCN ATGAPSPTLM WLKDGNPVSP AGTPGLQVFP GGRVLTLASA 

      2050       2060       2070       2080       2090       2100 
RASDSGRYSC VAVSAVGEDR QDVVLQVHMP PSILGEELNV SVVANESVAL ECQSHAMPPP 

      2110       2120       2130       2140       2150       2160 
VLSWWKDGRP LEPRPGVHLS ADKALLQVDR ADVWDAGHYT CEALNQAGHS EKHYNLNVWV 

      2170       2180       2190       2200       2210       2220 
APVFPLRESH TLTVREGHPT SLSCECRGVP FPKISWRKDG QPLPGEGAGL QHVSAVGRLL 

      2230       2240       2250       2260       2270       2280 
YLGQAQLAQE GTYTCECSNV VGNSSQDLQL EVHVPPQIAG PREPPTQVSV VQDGVATLEC 

      2290       2300       2310       2320       2330       2340 
NATGKPPPTV TWERDGQPVG AELGLQLQNQ GQSLHVERAQ AAHTGRYSCV AENLAGRAER 

      2350       2360       2370       2380       2390       2400 
KFELSVLVPP ELIGDLDPLT NITAALHSPL TLLCEAMGIP PPAIRWFRGE EPVSPGEDTY 

      2410       2420       2430       2440       2450       2460 
LLAGGWMLKM TQTQEQDSGL YSCLASNEAG EARRNFSVEV LVPPSIENED LEEVIKVLDG 

      2470       2480       2490       2500       2510       2520 
QTAHLMCNVT GHPQPKLTWF KDGRPLARGD AHHISPDGVL LQVLQANLSS AGHYSCIAAN 

      2530       2540       2550       2560       2570       2580 
AVGEKTKHFQ LSVLLAPTIL GGAEDSADEE VTVTVNNPIS LICEALAFPS PNITWMKDGA 

      2590       2600       2610       2620       2630       2640 
PFEASRNIQL LPGTHGLQIL NAQKEDAGQY TCVVTNELGE AVKNYHVEVL IPPSISKDDP 

      2650       2660       2670       2680       2690       2700 
LGEVGVKEVK TKVNSTLTLE CESWAVPPPT IRWYKDGQPV TPSSRLQVLG EGRLLQIQPT 

      2710       2720       2730       2740       2750       2760 
QVSDSGRYLC VATNVAGEDD QDFNVLIQVP PMFQKVGDFS AAFEILSREE EARGGVTEYR 

      2770       2780       2790       2800       2810       2820 
EIVENNPAYL YCDTNAIPPP DLTWYREDQP LSAGDEVSVL QGGRVLQIPL VRAENAGRYS 

      2830       2840       2850       2860       2870       2880 
CKASNEVGED WLHYELLVLT PPVILGDTEE LVEEVTVNAS STVSLQCPAL GNPVPTISWL 

      2890       2900       2910       2920       2930       2940 
QNGLPFSPSP RLQVLEDGQV LQVSTAEVAD AASYMCVAEN QAGSAEKLFT LRVQVPPRIA 

      2950       2960       2970       2980       2990       3000 
GLDLEQVTAI LNSSVSLPCD VHAHPNPEVT WYKDSQALSL GEEVFLLPGT HTLQLGRARL 

      3010       3020       3030       3040       3050       3060 
SDSGMYTCEA LNAAGRDQKL VQLSVLVPPA FRQAPRGPQD AVLVRVGDKA VLSCETDALP 

      3070       3080       3090       3100       3110       3120 
EPTVTWYKDG QPLVLAQRTQ ALRGGQRLEI QEAQVSDKGL YSCKVSNVAG EAVRTFTLTV 

      3130       3140       3150       3160       3170       3180 
QVPPTFENPK TETVSQVAGS PLVLTCDVSG VPAPTVTWLK DRMPVESSAV HGVVSRGGRL 

      3190       3200       3210       3220       3230       3240 
QLSRLQPAQA GTYTCVAENT QAEARKDFVV AVLVAPRIRS SGVAREHHVL EGQEVRLDCE 

      3250       3260       3270       3280       3290       3300 
ADGQPPPDVA WLKDGSPLGQ DMGPHLRFYL DGGSLVLKGL RASDAGAYTC VAHNPAGEDA 

      3310       3320       3330       3340       3350       3360 
RLHTVNVLVP PTIKQGADGS GTLVSRPGEL VTMVCPVRGS PPIHVSWLKD GLPLPLSQRT 

      3370       3380       3390       3400       3410       3420 
LLHGSGHTLR ISKVQLADAG IFTCVAASPA GVADRNFTLQ VQVPPVLEPV EFQNDVVVVR 

      3430       3440       3450       3460       3470       3480 
GSLVELPCEA RGVPLPLVSW MKDGEPLLSQ SLEQGPSLQL EAVGAGDSGT YSCVAVSEAG 

      3490       3500       3510       3520       3530       3540 
EARRHFQLTV MEPPHIEDSG QPTELSLTPG APMELLCDAQ GTPQPNITWH KDGQALTRLE 

      3550       3560       3570       3580       3590       3600 
NNSRATRVLR VRDAGLYTCL AESPAGAIEK SFRVRVQAPP NIVGPRGPRF VVGLAPGQLV 

      3610       3620       3630       3640       3650       3660 
LECSVEAEPA PKITWHRDGI VLQEDAHTQF PERGRFLQLQ ALSTADSGDY SCTARNAAGS 

      3670       3680       3690       3700       3710       3720 
TSVAFRVEIH TVPTIRSGPP AVNVSVNQTA LLPCQADGVP APLVSWRKDR VPLDPRSPRF 

      3730       3740       3750       3760       3770       3780 
EILPEGSLRI QPVLAQDAGH YLCLASNSAG SDRQGRDLRV LEPPAIAPSP SNLTLTAHTP 

      3790       3800       3810       3820       3830       3840 
ALLPCEASGS PKPLVVWWKD GQKLDFRLQQ GAYRLLPSNA LLLTAPGPQD SAQFECVVSN 

      3850       3860       3870       3880       3890       3900 
EVGEAHRLYQ VTVHVPPTIA DDQTDFTVTM MAPVVLTCHS TGIPAPTVSW SKAGAQLGAR 

      3910       3920       3930       3940       3950       3960 
GSGYRVSPSG ALEIGQALPI HAGRYTCSAR NSAGVAHKHV FLTVQASPVV KPLPSVVRAV 

      3970       3980       3990       4000       4010       4020 
AEEEVLLPCE ASGIPRPTIT WQKEGLNVAT GVSTQVLPGG QLRIAHASPE DAGNYLCIAK 

      4030       4040       4050       4060       4070       4080 
NSAGSAMGKT RLVVQVPPVI ENGLPDLSTT EGSHAFLPCK ARGSPEPNIT WDKDGQPVSG 

      4090       4100       4110       4120       4130       4140 
AEGKFTIQPS GELLVKNLEG QDAGTYTCTA ENAVGRARRR VHLTILVLPV FTTLPGDRSL 

      4150       4160       4170       4180       4190       4200 
RLGDRLWLRC AARGSPTPRI GWTVNDRPVT EGVSEQDGGS TLQRAAVSRE DSGTYVCWAE 

      4210       4220       4230       4240       4250       4260 
NRVGRTQAVS FVHVKEAPVL QGEAFSYLVE PVGGSIQLDC VVRGDPVPDI HWIKDGLPLR 

      4270       4280       4290       4300       4310       4320 
GSHLRHQLQN GSLTIHRTER DDAGRYQCLA ENEMGVAKKV VILVLQSAPV FQVEPQDMTV 

      4330       4340       4350       4360       4370       4380 
RSGDDVALRC QATGEPTPTI EWLQAGQPLR ASRRLRTLPD GSLWLENVET GDAGTYDCVA 

      4390       4400       4410       4420       4430       4440 
HNLLGSATAR AFLVVRGEPQ GSWGSMTGVI NGRKFGVATL NTSVMQEAHS GVSSIHSSIR 

      4450       4460       4470       4480       4490       4500 
HVPANVGPLM RVLVVTIAPI YWALARESGE ALNGHSLTGG RFRQESHVEF ATGELLTMTQ 

      4510       4520       4530       4540       4550       4560 
VARGLDPDGL LLLDVVVNGV VPESLADADL QVQDFEEHYV QTGPGQLFVG STQRFFQGGL 

      4570       4580       4590       4600       4610       4620 
PSFLRCNHSI QYNAARGPQP QLVQHLRASA ISSAFDPEAE ALRFQLATAL QAEENEVGCP 

      4630       4640       4650       4660       4670       4680 
EGFELDSQGA FCVDRDECSG GPSPCSHACL NAPGRFSCTC PTGFALAWDD RNCRDVDECA 

      4690       4700       4710       4720       4730       4740 
WDAHLCREGQ RCVNLLGSYR CLPDCGPGFR VADGAGCEDV DECLEGLDDC HYNQLCENTP 

      4750       4760       4770       4780       4790       4800 
GGHRCSCPRG YRMQGPSLPC LDVNECLQLP KACAYQCHNL QGSYRCLCPP GQTLLRDGKA 

      4810       4820       4830       4840       4850       4860 
CTSLERNGQN VTTVSHRGPL LPWLRPWASI PGTSYHAWVS LRPGPMALSS VGRAWCPPGF 

      4870       4880       4890       4900       4910       4920 
IRQNGVCTDL DECRVRNLCQ HACRNTEGSY QCLCPAGYRL LPSGKNCQDI NECEEESIEC 

      4930       4940       4950       4960       4970       4980 
GPGQMCFNTR GSYQCVDTPC PATYRQGPSP GTCFRRCSQD CGTGGPSTLQ YRLLPLPLGV 

      4990       5000       5010       5020       5030       5040 
RAHHDVARLT AFSEVGVPAN RTELSMLEPD PRSPFALRPL RAGLGAVYTR RALTRAGLYR 

      5050       5060 
LTVRAAAPRH QSVFVLLIAV SPYPY 

« Hide

Isoform 2 [UniParc].

Checksum: E5A1ACDF3CABD317
Show »

FASTA4,198448,332
Isoform 3 [UniParc].

Checksum: 378B87433B805BF9
Show »

FASTA4,427474,146

References

[1]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3793-4508 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4762-5065 (ISOFORM 1).
Tissue: Small intestine and Thymus.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3088-5065 (ISOFORM 3).
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL354898 Genomic DNA. No translation available.
AL360004 Genomic DNA. No translation available.
CH471090 Genomic DNA. Translation: EAW87931.1. Sequence problems.
AK074396 mRNA. Translation: BAB85069.1. Different initiation.
AK093583 mRNA. Translation: BAC04201.1. Different initiation.
AL834139 mRNA. Translation: CAD38854.1.
UniGeneHs.32194.
Hs.512559.

3D structure databases

ProteinModelPortalQ8NDA2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000277491.

PTM databases

PhosphoSiteQ8NDA2.

Polymorphism databases

DMDM298351848.

Proteomic databases

PaxDbQ8NDA2.
PRIDEQ8NDA2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302481; ENSP00000305590; ENSG00000148357.
ENST00000597795; ENSP00000472503; ENSG00000269324.

Organism-specific databases

GeneCardsGC09P133029.
H-InvDBHIX0008467.
HGNCHGNC:21293. HMCN2.
HPAHPA053903.
HPA060387.
neXtProtNX_Q8NDA2.
PharmGKBPA142671680.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000172035.
HOVERGENHBG073398.
OrthoDBEOG78D7KD.
PhylomeDBQ8NDA2.

Gene expression databases

ArrayExpressQ8NDA2.
BgeeQ8NDA2.

Family and domain databases

Gene3D2.40.155.10. 1 hit.
2.60.40.10. 42 hits.
InterProIPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR006605. G2_nidogen/fibulin_G2F.
IPR009017. GFP.
IPR023413. GFP_like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002035. VWF_A.
[Graphical view]
PfamPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 4 hits.
PF07474. G2F. 1 hit.
PF07679. I-set. 39 hits.
[Graphical view]
SMARTSM00179. EGF_CA. 6 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 40 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF53300. SSF53300. 1 hit.
SSF54511. SSF54511. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEPS00010. ASX_HYDROXYL. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 5 hits.
PS50835. IG_LIKE. 40 hits.
PS50993. NIDOGEN_G2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ8NDA2.

Entry information

Entry nameHMCN2_HUMAN
AccessionPrimary (citable) accession number: Q8NDA2
Secondary accession number(s): Q8N225, Q8TCI8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: April 16, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM